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Conserved domains on  [gi|499222646|ref|WP_010920186|]
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energy transducer TonB [Caulobacter vibrioides]

Protein Classification

energy transducer TonB( domain architecture ID 10018802)

energy transducer TonB interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates such as cobalamin, and various iron compounds (such as iron dicitrate, enterochelin, aerobactin, etc.)

Gene Ontology:  GO:0016020

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
tonB_Cterm TIGR01352
TonB family C-terminal domain; This model represents the C-terminal of TonB and is homologs. ...
 164-237 6.22e-15

TonB family C-terminal domain; This model represents the C-terminal of TonB and is homologs. TonB is an energy-transducer for TonB-dependent receptors of Gram-negative bacteria. Most members are designated as TonB or TonB-related proteins, but a few represent the paralogous TolA protein. Several bacteria have up to four TonB paralogs. In nearly every case, a proline-rich repetive region is found N-terminal to this domain; these low-complexity regions are highly divergent and cannot readily be aligned. The region is suggested to help span the periplasm. [Transport and binding proteins, Cations and iron carrying compounds]


:

Pssm-ID: 273570 [Multi-domain]  Cd Length: 74  Bit Score: 67.33  E-value: 6.22e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 499222646  164 ESAQRRGLSGQVTLNCMVALNGTVRDCVVAtESPADEGFGSAALKISRFFKMKPQTENGDPVDgATVRIPIRFN 237
Cdd:TIGR01352   1 ARARRRGIEGTVVVRFTVDPSGRVTSVSVL-KSSGDRALDRAALEAVRKARFEPPPPPGGVVA-ASVTIPVRFK 72
 
Name Accession Description Interval E-value
tonB_Cterm TIGR01352
TonB family C-terminal domain; This model represents the C-terminal of TonB and is homologs. ...
 164-237 6.22e-15

TonB family C-terminal domain; This model represents the C-terminal of TonB and is homologs. TonB is an energy-transducer for TonB-dependent receptors of Gram-negative bacteria. Most members are designated as TonB or TonB-related proteins, but a few represent the paralogous TolA protein. Several bacteria have up to four TonB paralogs. In nearly every case, a proline-rich repetive region is found N-terminal to this domain; these low-complexity regions are highly divergent and cannot readily be aligned. The region is suggested to help span the periplasm. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273570 [Multi-domain]  Cd Length: 74  Bit Score: 67.33  E-value: 6.22e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 499222646  164 ESAQRRGLSGQVTLNCMVALNGTVRDCVVAtESPADEGFGSAALKISRFFKMKPQTENGDPVDgATVRIPIRFN 237
Cdd:TIGR01352   1 ARARRRGIEGTVVVRFTVDPSGRVTSVSVL-KSSGDRALDRAALEAVRKARFEPPPPPGGVVA-ASVTIPVRFK 72
TonB_C pfam03544
Gram-negative bacterial TonB protein C-terminal; The TonB_C domain is the well-characterized ...
 158-237 3.29e-13

Gram-negative bacterial TonB protein C-terminal; The TonB_C domain is the well-characterized C-terminal region of the TonB receptor molecule. This protein is bound to an inner membrane-bound protein ExbB via a globular domain and has a flexible middle region that is likely to help in positioning the C-terminal domain into the iron-transporter barrel in the outer membrane. TonB_C interacts with the N-terminal TonB box of the outer membrane transporter that binds the Fe3+-siderophore complex. The barrel of the transporter, consisting of 22 beta-sheets and an inside plug, binds the iron complex in the barrel entrance.


Pssm-ID: 427361 [Multi-domain]  Cd Length: 79  Bit Score: 63.07  E-value: 3.29e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499222646  158 MARYYPESAQRRGLSGQVTLNCMVALNGTVRDCVVATESPADEgFGSAALKISRFFKMKPQTENGDPVDgATVRIPIRFN 237
Cdd:pfam03544   1 PEPVYPEEARRRGIEGTVVVEFLIDPDGNVTNVRVVKSSGYSI-LDEAALEAVKKWRFKPAPKNGQPVT-VEITVPIRFK 78
TonB COG0810
Periplasmic protein TonB, links inner and outer membranes [Cell wall/membrane/envelope ...
 163-232 5.50e-11

Periplasmic protein TonB, links inner and outer membranes [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440572 [Multi-domain]  Cd Length: 70  Bit Score: 56.82  E-value: 5.50e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499222646 163 PESAQRRGLSGQVTLNCMVALNGTVRDCVVAtESPADEGFGSAALKISRFFKMKPQTENGDPVDGATVRI 232
Cdd:COG0810    1 PEEARRRGIEGTVTVRFTIDADGRVTDVEVV-KSSGHPLLDEAALRAVRRWRFKPAKQNGKPVRVKTVPI 69
 
Name Accession Description Interval E-value
tonB_Cterm TIGR01352
TonB family C-terminal domain; This model represents the C-terminal of TonB and is homologs. ...
 164-237 6.22e-15

TonB family C-terminal domain; This model represents the C-terminal of TonB and is homologs. TonB is an energy-transducer for TonB-dependent receptors of Gram-negative bacteria. Most members are designated as TonB or TonB-related proteins, but a few represent the paralogous TolA protein. Several bacteria have up to four TonB paralogs. In nearly every case, a proline-rich repetive region is found N-terminal to this domain; these low-complexity regions are highly divergent and cannot readily be aligned. The region is suggested to help span the periplasm. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273570 [Multi-domain]  Cd Length: 74  Bit Score: 67.33  E-value: 6.22e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 499222646  164 ESAQRRGLSGQVTLNCMVALNGTVRDCVVAtESPADEGFGSAALKISRFFKMKPQTENGDPVDgATVRIPIRFN 237
Cdd:TIGR01352   1 ARARRRGIEGTVVVRFTVDPSGRVTSVSVL-KSSGDRALDRAALEAVRKARFEPPPPPGGVVA-ASVTIPVRFK 72
TonB_C pfam03544
Gram-negative bacterial TonB protein C-terminal; The TonB_C domain is the well-characterized ...
 158-237 3.29e-13

Gram-negative bacterial TonB protein C-terminal; The TonB_C domain is the well-characterized C-terminal region of the TonB receptor molecule. This protein is bound to an inner membrane-bound protein ExbB via a globular domain and has a flexible middle region that is likely to help in positioning the C-terminal domain into the iron-transporter barrel in the outer membrane. TonB_C interacts with the N-terminal TonB box of the outer membrane transporter that binds the Fe3+-siderophore complex. The barrel of the transporter, consisting of 22 beta-sheets and an inside plug, binds the iron complex in the barrel entrance.


Pssm-ID: 427361 [Multi-domain]  Cd Length: 79  Bit Score: 63.07  E-value: 3.29e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499222646  158 MARYYPESAQRRGLSGQVTLNCMVALNGTVRDCVVATESPADEgFGSAALKISRFFKMKPQTENGDPVDgATVRIPIRFN 237
Cdd:pfam03544   1 PEPVYPEEARRRGIEGTVVVEFLIDPDGNVTNVRVVKSSGYSI-LDEAALEAVKKWRFKPAPKNGQPVT-VEITVPIRFK 78
TonB COG0810
Periplasmic protein TonB, links inner and outer membranes [Cell wall/membrane/envelope ...
 163-232 5.50e-11

Periplasmic protein TonB, links inner and outer membranes [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440572 [Multi-domain]  Cd Length: 70  Bit Score: 56.82  E-value: 5.50e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499222646 163 PESAQRRGLSGQVTLNCMVALNGTVRDCVVAtESPADEGFGSAALKISRFFKMKPQTENGDPVDGATVRI 232
Cdd:COG0810    1 PEEARRRGIEGTVTVRFTIDADGRVTDVEVV-KSSGHPLLDEAALRAVRRWRFKPAKQNGKPVRVKTVPI 69
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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