|
Name |
Accession |
Description |
Interval |
E-value |
| MurF |
COG0770 |
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; ... |
3-452 |
0e+00 |
|
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl pentapeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440533 [Multi-domain] Cd Length: 451 Bit Score: 555.10 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 3 KPLSLSQLTTALKGQHIG-GDATFTGVSIDSRSVSAGQLFVALAGPRFDGHDYLADVKAKGAVAALVEREVaDVDLPQLQ 81
Cdd:COG0770 1 ILLTLAEIAEATGGRLIGdPDLVVTGVSTDSRKIKPGDLFVALKGERFDGHDFVAQALAKGAAAALVSRPL-PADLPLIV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 82 VADCRLALGQLGALNRAAFDKPVVAITGSSGKTTVKEMLASILRTRGLVHATRGNLNNDLGAPLTLLEIAPEHSAAVIEL 161
Cdd:COG0770 80 VDDTLKALQQLAAAHRARFNIPVIAITGSNGKTTTKEMLAAVLSTKGKVLATPGNFNNEIGVPLTLLRLPEDHEFAVLEM 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 162 GASRIGEIRYTVGLTQPQVVIINNAGTAHVGEFGGPDKIVEAKGEILEGLGQGGIAILNLDDKAFDIWKARAGAhKVVSF 241
Cdd:COG0770 160 GMNHPGEIAYLARIARPDIAVITNIGPAHLEGFGSLEGIARAKGEIFEGLPPGGVAVLNADDPLLAALAERAKA-RVLTF 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 242 ARsNPKADFHASDIGRDARGcPSFTLHGAGETVAVQLNVLGEHNVSNALAAAAAAHAVGLSLSGIAAGLAAVQPVKGRTV 321
Cdd:COG0770 239 GL-SEDADVRAEDIELDEDG-TRFTLHTPGGELEVTLPLPGRHNVSNALAAAAVALALGLDLEEIAAGLAAFQPVKGRLE 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 322 AQIAPNGVRVIDDSYNANPTSMCAAIDILAGFS--GRTVLVLGDIGELGQWAEEGHRQVGDYARG-KVDALYAVGSNMTH 398
Cdd:COG0770 317 VIEGAGGVTLIDDSYNANPDSMKAALDVLAQLPggGRRIAVLGDMLELGEESEELHREVGELAAElGIDRLFTVGELARA 396
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*
gi 499254911 399 AVKAFGA-NGRHFATQAELIDAVSAENASDTTILIKGSRSAAMENVVAALCGASG 452
Cdd:COG0770 397 IAEAAGGeRAEHFEDKEELLAALKALLRPGDVVLVKGSRGMGLERVVEALKEGAA 451
|
|
| murF |
TIGR01143 |
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the ... |
30-447 |
7.42e-167 |
|
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the strictly bacterial MurF gene of peptidoglycan biosynthesis. This enzyme is almost always UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanyl ligase, but in a few species, MurE adds lysine rather than diaminopimelate. This enzyme acts on the product from MurE activity, and so is also subfamily rather than equivalog. Staphylococcus aureus is an example of species in this MurF protein would differ. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273468 [Multi-domain] Cd Length: 417 Bit Score: 475.99 E-value: 7.42e-167
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 30 IDSRSVSAGQLFVALAGPRFDGHDYLADVKAKGAVAALVEREV-ADVDLPQLQVADCRLALGQLGALNRAAFDKPVVAIT 108
Cdd:TIGR01143 1 TDSRAIKPGDLFIALKGERFDGHDFVEQALAAGAVAVVVDREVgPDNGLPQILVDDTLEALQALARAKRAKFSGKVIGIT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 109 GSSGKTTVKEMLASILRTRGLVHATRGNLNNDLGAPLTLLEIAPEHSAAVIELGASRIGEIRYTVGLTQPQVVIINNAGT 188
Cdd:TIGR01143 81 GSSGKTTTKEMLAAILSHKYKVFATPGNFNNEIGLPLTLLRAPGDHDYAVLEMGASHPGEIAYLAEIAKPDIAVITNIGP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 189 AHVGEFGGPDKIVEAKGEILEGLGQGGIAILNLDDKAFDIWKARAGAHKVVSFARSNpkADFHASDIGRDARGCPSFTLH 268
Cdd:TIGR01143 161 AHLEGFGSLEGIAEAKGEILQGLKENGIAVINADDPAFADLAKRLPNRNILSFGFEG--GDFVAKDISYSALGSTSFTLV 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 269 GAGETVAVQLNVLGEHNVSNALAAAAAAHAVGLSLSGIAAGLAAVQPVKGRTVaQIAPNGVRVIDDSYNANPTSMCAAID 348
Cdd:TIGR01143 239 APGGEFEVSLPLLGRHNVMNALAAAALALELGIPLEEIAEGLAELKLVKGRFE-VQTKNGLTLIDDTYNANPDSMRAALD 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 349 ILAGFSGRTVLVLGDIGELGQWAEEGHRQVGDYARGK-VDALYAVGSNMTHAVKAFGANGRHFATQAELIDAVSAENASD 427
Cdd:TIGR01143 318 ALARFPGKKILVLGDMAELGEYSEELHAEVGRYANSLgIDLVFLVGEEAAVIYDSFGKQGKHFADKDELLAFLKTLVRKG 397
|
410 420
....*....|....*....|
gi 499254911 428 TTILIKGSRSAAMENVVAAL 447
Cdd:TIGR01143 398 DVVLVKGSRSVKLEKVVEAL 417
|
|
| murF |
PRK10773 |
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed |
4-447 |
1.84e-142 |
|
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed
Pssm-ID: 182718 [Multi-domain] Cd Length: 453 Bit Score: 415.20 E-value: 1.84e-142
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 4 PLSLSQLTTALKGQHIGGDATFTGVSIDSRSVSAGQLFVALAGPRFDGHDYLADVKAKGAVAALVEREVaDVDLPQLQVA 83
Cdd:PRK10773 3 SVTLSQLADILNGELQGADITIDAVTTDTRKVTPGCLFVALKGERFDAHDFADDAKAAGAGALLVSRPL-DIDLPQLVVK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 84 DCRLALGQLGALNRAAFDKPVVAITGSSGKTTVKEMLASILRTRGLVHATRGNLNNDLGAPLTLLEIAPEHSAAVIELGA 163
Cdd:PRK10773 82 DTRLAFGQLAAWVRQQVPARVVALTGSSGKTSVKEMTAAILRQCGNTLYTAGNLNNDIGVPLTLLRLTPEHDYAVIELGA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 164 SRIGEIRYTVGLTQPQVVIINNAGTAHVGEFGGPDKIVEAKGEILEGLGQGGIAILNLDDKAFDIWKARAGAHKVVSFA- 242
Cdd:PRK10773 162 NHQGEIAYTVSLTRPEAALVNNLAAAHLEGFGSLAGVAKAKGEIFSGLPENGIAIMNADSNDWLNWQSVIGSKTVWRFSp 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 243 RSNPKADFHASDIGRDARGCpSFTLHGAGETVAVQLNVLGEHNVSNALAAAAAAHAVGLSLSGIAAGLAAVQPVKGRTVA 322
Cdd:PRK10773 242 NAANSVDFTATNIHVTSHGT-EFTLHTPTGSVDVLLPLPGRHNIANALAAAALAMSVGATLDAVKAGLANLKAVPGRLFP 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 323 QIAPNGVRVIDDSYNANPTSMCAAIDILAGFSGRTVLVLGDIGELGQWAEEGHRQVGDYAR-GKVDALYAVGsNMTHAVK 401
Cdd:PRK10773 321 IQLAEGQLLLDDSYNANVGSMTAAAQVLAEMPGYRVMVVGDMAELGAESEACHRQVGEAAKaAGIDKVLSVG-KLSHAIS 399
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 499254911 402 AFGANGRHFATQAELIDAVSA--ENASDTTILIKGSRSAAMENVVAAL 447
Cdd:PRK10773 400 EASGVGEHFADKTALIARLKAllAEHQVITILVKGSRSAAMEEVVRAL 447
|
|
| Mur_ligase_M |
pfam08245 |
Mur ligase middle domain; |
107-288 |
2.48e-46 |
|
Mur ligase middle domain;
Pssm-ID: 462409 [Multi-domain] Cd Length: 199 Bit Score: 159.01 E-value: 2.48e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 107 ITGSSGKTTVKEMLASILRTRGLVHATRG--------NLNNDLGAPLTLLEIAP-EHSAAVIELGASRIGEIRYtVGLTQ 177
Cdd:pfam08245 1 VTGTNGKTTTTELIAAILSLAGGVIGTIGtyigksgnTTNNAIGLPLTLAEMVEaGAEYAVLEVSSHGLGEGRL-SGLLK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 178 PQVVIINNAGTAHVGEFGGPDKIVEAKGEILEGLGQGGIAILNLDDKAFDIWKARAGAH--KVVSFARSNpKADFHASDI 255
Cdd:pfam08245 80 PDIAVFTNISPDHLDFHGTMENYAKAKAELFEGLPEDGIAVINADDPYGAFLIAKLKKAgvRVITYGIEG-EADLRAANI 158
|
170 180 190
....*....|....*....|....*....|...
gi 499254911 256 GRDARGCPSFTLHGAGETVAVQLNVLGEHNVSN 288
Cdd:pfam08245 159 ELSSDGTSFDLFTVPGGELEIEIPLLGRHNVYN 191
|
|
| F430_CfbE |
NF033197 |
coenzyme F430 synthase; Members of this family are coenzyme F430 synthase, involving in ... |
88-373 |
4.33e-09 |
|
coenzyme F430 synthase; Members of this family are coenzyme F430 synthase, involving in synthesizing coenzyme F430, which is used in methanogens by coenzyme M reductase. Members of this family are restricted to archaeal methanogens, and resemble (and may be misannotated as) MurD, an enzyme of bacterial cell wall biosynthesis.
Pssm-ID: 467992 [Multi-domain] Cd Length: 419 Bit Score: 58.11 E-value: 4.33e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 88 ALGQLGALNRAAFDKPVVAITGSSGKTTVKEMLASILRTR-GLVHATRGNLNNDLGAPLTLLEIAPehsAAVIEL--GAS 164
Cdd:NF033197 78 AVGEILKKKYGRIPKKFIEITGVKGKTTTAELLAHILSDEyVLLHTSRGTERYPEGELSNKGSITP---ASILNAleLAE 154
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 165 RIGEIRYTvgltqpqvviinnagtahvgefggpDKIVEakgEILEGLGQGGIAIL-NLDDKaFDIWKAR--AGAHKVVSF 241
Cdd:NF033197 155 EIGIDDYG-------------------------FLIFE---VSLGGTGAGDVGIItNILED-YPIAGGKrsASAAKLQSL 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 242 ARS--------NPKADFHASDI----GRDARGCPSFTLHGAGETVAVQLN--VLGEHNVSNALAAAAAAHAVGLSLSGIA 307
Cdd:NF033197 206 KNAkvgsinvaDLGIYINGKNKlvitVAGVEILSKYPLRFKYGNTEFEFNplLFGPHYRENSLFAIEAALNLGVDPEDII 285
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 499254911 308 AGLAAVQPVKGRT-VAQIapNGVRVIDdsyNANP----TSMCAAIDILAGFSGRTVLVLGdiGELGQWAEE 373
Cdd:NF033197 286 SALKGFKGLPGRMaVKKE--GGVVIVD---NINPglnvKAIEYALDDALELLGDGTLVIG--GDFGVVCEE 349
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| MurF |
COG0770 |
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; ... |
3-452 |
0e+00 |
|
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl pentapeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440533 [Multi-domain] Cd Length: 451 Bit Score: 555.10 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 3 KPLSLSQLTTALKGQHIG-GDATFTGVSIDSRSVSAGQLFVALAGPRFDGHDYLADVKAKGAVAALVEREVaDVDLPQLQ 81
Cdd:COG0770 1 ILLTLAEIAEATGGRLIGdPDLVVTGVSTDSRKIKPGDLFVALKGERFDGHDFVAQALAKGAAAALVSRPL-PADLPLIV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 82 VADCRLALGQLGALNRAAFDKPVVAITGSSGKTTVKEMLASILRTRGLVHATRGNLNNDLGAPLTLLEIAPEHSAAVIEL 161
Cdd:COG0770 80 VDDTLKALQQLAAAHRARFNIPVIAITGSNGKTTTKEMLAAVLSTKGKVLATPGNFNNEIGVPLTLLRLPEDHEFAVLEM 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 162 GASRIGEIRYTVGLTQPQVVIINNAGTAHVGEFGGPDKIVEAKGEILEGLGQGGIAILNLDDKAFDIWKARAGAhKVVSF 241
Cdd:COG0770 160 GMNHPGEIAYLARIARPDIAVITNIGPAHLEGFGSLEGIARAKGEIFEGLPPGGVAVLNADDPLLAALAERAKA-RVLTF 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 242 ARsNPKADFHASDIGRDARGcPSFTLHGAGETVAVQLNVLGEHNVSNALAAAAAAHAVGLSLSGIAAGLAAVQPVKGRTV 321
Cdd:COG0770 239 GL-SEDADVRAEDIELDEDG-TRFTLHTPGGELEVTLPLPGRHNVSNALAAAAVALALGLDLEEIAAGLAAFQPVKGRLE 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 322 AQIAPNGVRVIDDSYNANPTSMCAAIDILAGFS--GRTVLVLGDIGELGQWAEEGHRQVGDYARG-KVDALYAVGSNMTH 398
Cdd:COG0770 317 VIEGAGGVTLIDDSYNANPDSMKAALDVLAQLPggGRRIAVLGDMLELGEESEELHREVGELAAElGIDRLFTVGELARA 396
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*
gi 499254911 399 AVKAFGA-NGRHFATQAELIDAVSAENASDTTILIKGSRSAAMENVVAALCGASG 452
Cdd:COG0770 397 IAEAAGGeRAEHFEDKEELLAALKALLRPGDVVLVKGSRGMGLERVVEALKEGAA 451
|
|
| murF |
TIGR01143 |
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the ... |
30-447 |
7.42e-167 |
|
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the strictly bacterial MurF gene of peptidoglycan biosynthesis. This enzyme is almost always UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanyl ligase, but in a few species, MurE adds lysine rather than diaminopimelate. This enzyme acts on the product from MurE activity, and so is also subfamily rather than equivalog. Staphylococcus aureus is an example of species in this MurF protein would differ. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273468 [Multi-domain] Cd Length: 417 Bit Score: 475.99 E-value: 7.42e-167
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 30 IDSRSVSAGQLFVALAGPRFDGHDYLADVKAKGAVAALVEREV-ADVDLPQLQVADCRLALGQLGALNRAAFDKPVVAIT 108
Cdd:TIGR01143 1 TDSRAIKPGDLFIALKGERFDGHDFVEQALAAGAVAVVVDREVgPDNGLPQILVDDTLEALQALARAKRAKFSGKVIGIT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 109 GSSGKTTVKEMLASILRTRGLVHATRGNLNNDLGAPLTLLEIAPEHSAAVIELGASRIGEIRYTVGLTQPQVVIINNAGT 188
Cdd:TIGR01143 81 GSSGKTTTKEMLAAILSHKYKVFATPGNFNNEIGLPLTLLRAPGDHDYAVLEMGASHPGEIAYLAEIAKPDIAVITNIGP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 189 AHVGEFGGPDKIVEAKGEILEGLGQGGIAILNLDDKAFDIWKARAGAHKVVSFARSNpkADFHASDIGRDARGCPSFTLH 268
Cdd:TIGR01143 161 AHLEGFGSLEGIAEAKGEILQGLKENGIAVINADDPAFADLAKRLPNRNILSFGFEG--GDFVAKDISYSALGSTSFTLV 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 269 GAGETVAVQLNVLGEHNVSNALAAAAAAHAVGLSLSGIAAGLAAVQPVKGRTVaQIAPNGVRVIDDSYNANPTSMCAAID 348
Cdd:TIGR01143 239 APGGEFEVSLPLLGRHNVMNALAAAALALELGIPLEEIAEGLAELKLVKGRFE-VQTKNGLTLIDDTYNANPDSMRAALD 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 349 ILAGFSGRTVLVLGDIGELGQWAEEGHRQVGDYARGK-VDALYAVGSNMTHAVKAFGANGRHFATQAELIDAVSAENASD 427
Cdd:TIGR01143 318 ALARFPGKKILVLGDMAELGEYSEELHAEVGRYANSLgIDLVFLVGEEAAVIYDSFGKQGKHFADKDELLAFLKTLVRKG 397
|
410 420
....*....|....*....|
gi 499254911 428 TTILIKGSRSAAMENVVAAL 447
Cdd:TIGR01143 398 DVVLVKGSRSVKLEKVVEAL 417
|
|
| murF |
PRK10773 |
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed |
4-447 |
1.84e-142 |
|
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed
Pssm-ID: 182718 [Multi-domain] Cd Length: 453 Bit Score: 415.20 E-value: 1.84e-142
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 4 PLSLSQLTTALKGQHIGGDATFTGVSIDSRSVSAGQLFVALAGPRFDGHDYLADVKAKGAVAALVEREVaDVDLPQLQVA 83
Cdd:PRK10773 3 SVTLSQLADILNGELQGADITIDAVTTDTRKVTPGCLFVALKGERFDAHDFADDAKAAGAGALLVSRPL-DIDLPQLVVK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 84 DCRLALGQLGALNRAAFDKPVVAITGSSGKTTVKEMLASILRTRGLVHATRGNLNNDLGAPLTLLEIAPEHSAAVIELGA 163
Cdd:PRK10773 82 DTRLAFGQLAAWVRQQVPARVVALTGSSGKTSVKEMTAAILRQCGNTLYTAGNLNNDIGVPLTLLRLTPEHDYAVIELGA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 164 SRIGEIRYTVGLTQPQVVIINNAGTAHVGEFGGPDKIVEAKGEILEGLGQGGIAILNLDDKAFDIWKARAGAHKVVSFA- 242
Cdd:PRK10773 162 NHQGEIAYTVSLTRPEAALVNNLAAAHLEGFGSLAGVAKAKGEIFSGLPENGIAIMNADSNDWLNWQSVIGSKTVWRFSp 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 243 RSNPKADFHASDIGRDARGCpSFTLHGAGETVAVQLNVLGEHNVSNALAAAAAAHAVGLSLSGIAAGLAAVQPVKGRTVA 322
Cdd:PRK10773 242 NAANSVDFTATNIHVTSHGT-EFTLHTPTGSVDVLLPLPGRHNIANALAAAALAMSVGATLDAVKAGLANLKAVPGRLFP 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 323 QIAPNGVRVIDDSYNANPTSMCAAIDILAGFSGRTVLVLGDIGELGQWAEEGHRQVGDYAR-GKVDALYAVGsNMTHAVK 401
Cdd:PRK10773 321 IQLAEGQLLLDDSYNANVGSMTAAAQVLAEMPGYRVMVVGDMAELGAESEACHRQVGEAAKaAGIDKVLSVG-KLSHAIS 399
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 499254911 402 AFGANGRHFATQAELIDAVSA--ENASDTTILIKGSRSAAMENVVAAL 447
Cdd:PRK10773 400 EASGVGEHFADKTALIARLKAllAEHQVITILVKGSRSAAMEEVVRAL 447
|
|
| PRK11929 |
PRK11929 |
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ... |
27-447 |
4.12e-134 |
|
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;
Pssm-ID: 237025 [Multi-domain] Cd Length: 958 Bit Score: 409.86 E-value: 4.12e-134
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 27 GVSIDSRSVSAGQLFVALAGPRFDGHDYLADVKAKGAVAALVEREVADVDLPQLQVADCRLALGQLGALNRAAFDKPVVA 106
Cdd:PRK11929 528 AVSTDSRSVGRGELFVALRGENFDGHDYLPQAFAAGACAAVVERQVADVDLPQIVVDDTRAALGRLATAWRARFSLPVVA 607
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 107 ITGSSGKTTVKEMLASILRTR---GLVHATRGNLNNDLGAPLTLLEIAPEHSAAVIELGASRIGEIRYTVGLTQPQVVII 183
Cdd:PRK11929 608 ITGSNGKTTTKEMIAAILAAWqgeDRVLATEGNFNNEIGVPLTLLRLRAQHRAAVFELGMNHPGEIAYLAAIAAPTVALV 687
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 184 NNAGTAHVGEFGGPDKIVEAKGEILEGLGQGGIAILNLDDKAFDIWKARAGAHKVVSFARS---NPKADFHASDIGRDAR 260
Cdd:PRK11929 688 TNAQREHQEFMHSVEAVARAKGEIIAALPEDGVAVVNGDDPYTAIWAKLAGARRVLRFGLQpgaDVYAEKIAKDISVGEA 767
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 261 GCPSFTLHGAGETVAVQLNVLGEHNVSNALAAAAAAHAVGLSLSGIAAGLAAVQPVKGRTVAQIAPNGVRVIDDSYNANP 340
Cdd:PRK11929 768 GGTRCQVVTPAGSAEVYLPLIGEHNLRNALAAIACALAAGASLKQIRAGLERFQPVAGRMQRRRLSCGTRIIDDTYNANP 847
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 341 TSMCAAIDILAGF-SGRTVLVLGDIGELGQWAEEGHRQVGDYARGK-VDALYAVGSNMTHAVKAFGANGR-HFATQAELI 417
Cdd:PRK11929 848 DSMRAAIDVLAELpNGPRALVLGDMLELGDNGPAMHREVGKYARQLgIDALITLGEAARDAAAAFGAGARgVCASVDEII 927
|
410 420 430
....*....|....*....|....*....|
gi 499254911 418 DAVSAENASDTTILIKGSRSAAMENVVAAL 447
Cdd:PRK11929 928 AALRGALPEGDSVLIKGSRFMRLERVVDAL 957
|
|
| PRK14093 |
PRK14093 |
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase; ... |
26-447 |
6.49e-67 |
|
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional
Pssm-ID: 184501 [Multi-domain] Cd Length: 479 Bit Score: 221.57 E-value: 6.49e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 26 TGVSIDSRSVSAGQLFVALAGPRFDGHDYLADVKAKGAVAALVEREVAD---VDLPQLQVADCRLALGQLGALNRAAFDK 102
Cdd:PRK14093 29 TGISIDSRTLAPGDAYFAIKGDVHDGHAFVAAALKAGAALAVVERAQRDkfaADAPLLVVDDVLAALRDLGRAARARLEA 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 103 PVVAITGSSGKTTVKEMLASILRTRGLVHATRGNLNNDLGAPLTLLEIAPEHSAAVIELGASRIGEIRYTVGLTQPQVVI 182
Cdd:PRK14093 109 KVIAVTGSVGKTSTKEALRGVLGAQGETHASVASFNNHWGVPLSLARCPADARFAVFEIGMNHAGEIEPLVKMVRPHVAI 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 183 INNAGTAHVGEFGGPDKIVEAKGEILEGLGQGGIAILNLDDKAFDIWKARAGAH---KVVSFArSNPKADFHASDIGRDA 259
Cdd:PRK14093 189 ITTVEPVHLEFFSGIEAIADAKAEIFTGLEPGGAAVLNRDNPQFDRLAASARAAgiaRIVSFG-ADEKADARLLDVALHA 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 260 RgCPSFTLHGAGETVAVQLNVLGEHNVSNALAAAAAAHAVGLSLSGIAAGLAAVQPVKGRTVA---QIAPNGVRVIDDSY 336
Cdd:PRK14093 268 D-CSAVHADILGHDVTYKLGMPGRHIAMNSLAVLAAAELAGADLALAALALSQVQPAAGRGVRhtlEVGGGEATLIDESY 346
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 337 NANPTSMCAAIDILA----GFSGRTVLVLGDIGELGQWAEEGHRQVGDYAR-GKVDALYAVGSNMTHAVKAF--GANGRH 409
Cdd:PRK14093 347 NANPASMAAALGVLGrapvGPQGRRIAVLGDMLELGPRGPELHRGLAEAIRaNAIDLVFCCGPLMRNLWDALssGKRGGY 426
|
410 420 430
....*....|....*....|....*....|....*...
gi 499254911 410 FATQAELIDAVSAENASDTTILIKGSRSAAMENVVAAL 447
Cdd:PRK14093 427 AEDAAALESQVVAAIRAGDVIMVKGSLGSRMKTIVTAL 464
|
|
| PRK11930 |
PRK11930 |
putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine ... |
5-444 |
1.90e-54 |
|
putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine racemase; Provisional
Pssm-ID: 237026 [Multi-domain] Cd Length: 822 Bit Score: 194.41 E-value: 1.90e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 5 LSLSQLTTALKGQHIG-GDATFTGVSIDSRSVS--AGQLFVALAGPRFDGHDYLADVKAKGAVAALV------EREVADV 75
Cdd:PRK11930 3 YTLESISGILGAEGLGdKDAIIDQILTDSRSLSfpENTLFFALKGERNDGHRYIQELYEKGVRNFVVseekhpEESYPDA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 76 DLpqLQVADCRLALGQLGALNRAAFDKPVVAITGSSGKTTVKEMLASILRTRGLVHATRGNLNNDLGAPLTLLEIAPEHS 155
Cdd:PRK11930 83 NF--LKVKDPLKALQELAAYHRSQFDIPVIGITGSNGKTIVKEWLYQLLSPDYNIVRSPRSYNSQIGVPLSVWQLNEEHE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 156 AAVIELGASRIGEIRYTVGLTQPQVVIINNAGTAHVGEFGGPDKIVEAKgeiLEGLGQGGIAILNLDDKAFD-IWKARAG 234
Cdd:PRK11930 161 LGIFEAGISQPGEMEALQKIIKPTIGILTNIGGAHQENFRSIKQKIMEK---LKLFKDCDVIIYNGDNELISsCITKSNL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 235 AHKVVSFARSNPKADF---------HASDIgrdargcpsfTLHGAGETVAVQLNVLGEHNVSNALAAAAAAHAVGLSLSG 305
Cdd:PRK11930 238 TLKLISWSRKDPEAPLyipfvekkeDHTVI----------SYTYKGEDFHFEIPFIDDASIENLIHCIAVLLYLGYSADQ 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 306 IAAGLAAVQPVKGRTVAQIAPNGVRVIDDSYNANPTSMCAAIDIL--AGFSGRTVLVLGDIGELGQWAEEGHRQVGDYAR 383
Cdd:PRK11930 308 IQERMARLEPVAMRLEVKEGINNCTLINDSYNSDLQSLDIALDFLnrRSQSKKKTLILSDILQSGQSPEELYRKVAQLIS 387
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 499254911 384 -GKVDALYAVGSNMTHAVKAF-GANGRHFATQAELIDAVSAENASDTTILIKGSRSAAMENVV 444
Cdd:PRK11930 388 kRGIDRLIGIGEEISSEASKFeGTEKEFFKTTEAFLKSFAFLKFRNELILVKGARKFEFEQIT 450
|
|
| MurE |
COG0769 |
UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; ... |
27-362 |
2.87e-52 |
|
UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl tripeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440532 [Multi-domain] Cd Length: 459 Bit Score: 182.20 E-value: 2.87e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 27 GVSIDSRSVSAGQLFVALAGPRFDGHDYLADVKAKGAVAALVEREVA--DVDLPQLQVADCRLALGQLGAlnrAAFDKP- 103
Cdd:COG0769 1 GITYDSRKVKPGDLFVALPGARVDGHDFIAQAIARGAVAVVTEAPGAllAAGVPVIVVPDPRAALALLAA---AFYGHPs 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 104 ----VVAITGSSGKTTVKEMLASILRTRGLVHATRGNLNNDLG-----APLTLLEiAPE-H-----------SAAVIElg 162
Cdd:COG0769 78 qklkLIGVTGTNGKTTTTYLLAQILRALGKKTGLIGTVGNGIGgelipSSLTTPE-ALDlQrllaemvdagvTHVVME-- 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 163 AS-------RIGEIRYTVG----LTQPqvviinnagtaHVGEFGGPDKIVEAKGEILEGLGQGGIAILNLDDKAFDIWKA 231
Cdd:COG0769 155 VSshaldqgRVDGVRFDVAvftnLTRD-----------HLDYHGTMEAYFAAKARLFDQLGPGGAAVINADDPYGRRLAA 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 232 RAGAhKVVSFARsNPKADFHASDIGRDARGCpSFTLHGAGETVAVQLNVLGEHNVSNALAAAAAAHAVGLSLSGIAAGLA 311
Cdd:COG0769 224 AAPA-RVITYGL-KADADLRATDIELSADGT-RFTLVTPGGEVEVRLPLIGRFNVYNALAAIAAALALGIDLEEILAALE 300
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 499254911 312 AVQPVKGRTVAQIAPNGVRVIDDsYNANPTSMCAAIDILAGF-SGRTVLVLG 362
Cdd:COG0769 301 KLKGVPGRMERVDGGQGPTVIVD-YAHTPDALENVLEALRPHtKGRLIVVFG 351
|
|
| Mur_ligase_M |
pfam08245 |
Mur ligase middle domain; |
107-288 |
2.48e-46 |
|
Mur ligase middle domain;
Pssm-ID: 462409 [Multi-domain] Cd Length: 199 Bit Score: 159.01 E-value: 2.48e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 107 ITGSSGKTTVKEMLASILRTRGLVHATRG--------NLNNDLGAPLTLLEIAP-EHSAAVIELGASRIGEIRYtVGLTQ 177
Cdd:pfam08245 1 VTGTNGKTTTTELIAAILSLAGGVIGTIGtyigksgnTTNNAIGLPLTLAEMVEaGAEYAVLEVSSHGLGEGRL-SGLLK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 178 PQVVIINNAGTAHVGEFGGPDKIVEAKGEILEGLGQGGIAILNLDDKAFDIWKARAGAH--KVVSFARSNpKADFHASDI 255
Cdd:pfam08245 80 PDIAVFTNISPDHLDFHGTMENYAKAKAELFEGLPEDGIAVINADDPYGAFLIAKLKKAgvRVITYGIEG-EADLRAANI 158
|
170 180 190
....*....|....*....|....*....|...
gi 499254911 256 GRDARGCPSFTLHGAGETVAVQLNVLGEHNVSN 288
Cdd:pfam08245 159 ELSSDGTSFDLFTVPGGELEIEIPLLGRHNVYN 191
|
|
| murE |
PRK00139 |
UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional |
19-362 |
3.22e-35 |
|
UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional
Pssm-ID: 234660 [Multi-domain] Cd Length: 460 Bit Score: 136.03 E-value: 3.22e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 19 IGGDATFTGVSIDSRSVSAGQLFVALAGPRFDGHDYLADVKAKGAVAALVEREVAD-VDLPQLQVADCRLALGQLGAlnr 97
Cdd:PRK00139 9 LLAPVEITGLTYDSRKVKPGDLFVALPGHKVDGRDFIAQAIANGAAAVVAEADGEAgTGVPVIIVPDLRKALALLAA--- 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 98 AAFDKP-----VVAITGSSGKTTVKEMLASILRTRGLVHA---TRGN-LNNDL-------GAPLTLLEIAPE-----HSA 156
Cdd:PRK00139 86 AFYGHPsdklkLIGVTGTNGKTTTAYLLAQILRLLGEKTAligTLGNgIGGELipsglttPDALDLQRLLAElvdagVTY 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 157 AVIElgAS-------RIGEIRYTVG----LTQPqvviinnagtaHVGEFGGPDKIVEAKGEILEGLgqGGIAILNLDDKA 225
Cdd:PRK00139 166 AAME--VSshaldqgRVDGLKFDVAvftnLSRD-----------HLDYHGTMEDYLAAKARLFSEL--GLAAVINADDEV 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 226 FDIWKARAGAHKVvsfarSNPKADFHASDIgrdargcpSFTLHGAGETVA--VQLNVLGEHNVSNALAAAAAAHAVGLSL 303
Cdd:PRK00139 231 GRRLLALPDAYAV-----SMAGADLRATDV--------EYTDSGQTFTLVteVESPLIGRFNVSNLLAALAALLALGVPL 297
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 499254911 304 SGIAAGLAAVQPVKGR--TVAqiAPNGVRVIDDsYNANPTSMCAAIDILAGF-SGRTVLVLG 362
Cdd:PRK00139 298 EDALAALAKLQGVPGRmeRVD--AGQGPLVIVD-YAHTPDALEKVLEALRPHaKGRLICVFG 356
|
|
| PRK11929 |
PRK11929 |
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ... |
20-319 |
4.33e-33 |
|
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;
Pssm-ID: 237025 [Multi-domain] Cd Length: 958 Bit Score: 132.91 E-value: 4.33e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 20 GGDATFTGVSIDSRSVSAGQLFVALAGPRFDGHDYLADVKAKGAVAALVEREVADVDLP----QLQVADCRLALGQLGAL 95
Cdd:PRK11929 24 GCVAATADLRLDSREVQPGDLFVACRGAASDGRAFIDQALARGAAAVLVEAEGEDQVAAadalVLPVADLRKALGELAAR 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 96 --NRAAFDKPVVAITGSSGKTTVKEMLASILRTRGLVHATRGNLNNDLGA-----------PLTLLEI-----APEHSAA 157
Cdd:PRK11929 104 wyGRPSEQLSLVAVTGTNGKTSCAQLLAQLLTRLGKPCGSIGTLGARLDGrlipgslttpdAIILHRIlarmrAAGADAV 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 158 VIElgASRIGEIRYTVGLTQPQVVIINNAGTAHVGEFGGPDKIVEAKGEILEGLGQGGIAILNLDDKAFDIWKARAGAHK 237
Cdd:PRK11929 184 AME--ASSHGLEQGRLDGLRIAVAGFTNLTRDHLDYHGTMQDYEEAKAALFSKLPGLGAAVINADDPAAARLLAALPRGL 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 238 VVSFARSNPKADFHASDIGRDARGCpSFTLHGAGETVAVQLNVLGEHNVSNALAAAAAAHAVGLSLSGIAAGLAAVQPVK 317
Cdd:PRK11929 262 KVGYSPQNAGADVQARDLRATAHGQ-VFTLATPDGSYQLVTRLLGRFNVSNLLLVAAALKKLGLPLAQIARALAAVSPVP 340
|
..
gi 499254911 318 GR 319
Cdd:PRK11929 341 GR 342
|
|
| murE |
TIGR01085 |
UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, ... |
22-361 |
3.50e-30 |
|
UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase. An exception is Staphylococcus aureus, in which diaminopimelate is replaced by lysine in the peptidoglycan and MurE is EC 6.3.2.7. The Mycobacteria, part of the closest neighboring branch outside of the low-GC Gram-positive bacteria, use diaminopimelate. A close homolog, scoring just below the trusted cutoff, is found (with introns) in Arabidopsis thaliana. Its role is unknown. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273435 [Multi-domain] Cd Length: 464 Bit Score: 122.04 E-value: 3.50e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 22 DATFTGVSIDSRSVSAGQLFVALAGPRFDGHDYLADVKAKGAVAALVEREV--ADVDLPQLQVADCRLALGQLGAlnrAA 99
Cdd:TIGR01085 1 DLEVTGLTLDSREVKPGDLFVAIKGTHVDGHDFIHDAIANGAVAVVVERDVdfYVAPVPVIIVPDLRHALSSLAA---AF 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 100 FDKP-----VVAITGSSGKTTVKEMLASILRTRGLVHA---TRGN--LNNDL---------GAPLTL---LEIAPEHSA- 156
Cdd:TIGR01085 78 YGHPskklkVIGVTGTNGKTTTTSLIAQLLRLLGKKTGligTIGYrlGGNDLiknpaalttPEALTLqstLAEMVEAGAq 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 157 -AVIElgASRIGEIRYTVGLTQPQVVIINNAGTAHVGEFGGPDKIVEAKGEILEGLGQGGIAILNLDDKAFDIWKARAGA 235
Cdd:TIGR01085 158 yAVME--VSSHALAQGRVRGVRFDAAVFTNLSRDHLDFHGTMENYFAAKASLFTELGLKRFAVINLDDEYGAQFVKRLPK 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 236 HKVVSFARSNP---KADFHASDIGRDARGCpSFTLHGAGETVAVQLNVLGEHNVSNALAAAAAAHAVG-LSLSGIAAGLA 311
Cdd:TIGR01085 236 DITVSAITQPAdgrAQDIKITDSGYSFEGQ-QFTFETPAGEGHLHTPLIGRFNVYNLLAALATLLHLGgIDLEDIVAALE 314
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 499254911 312 AVQPVKGR-TVAQIAPNGVRVIDdsYNANPTSMCAAIDILAGFSGRTVLVL 361
Cdd:TIGR01085 315 KFRGVPGRmELVDGGQKFLVIVD--YAHTPDALEKALRTLRKHKDGRLIVV 363
|
|
| murD |
TIGR01087 |
UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation ... |
100-422 |
1.44e-22 |
|
UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273436 [Multi-domain] Cd Length: 433 Bit Score: 99.34 E-value: 1.44e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 100 FDKPVVAITGSSGKTTVKEMLASILRTRGLVHATRGNlnndLGAPltLLEIAPEHSAAVIELGASRIgEIRYTVGLTqPQ 179
Cdd:TIGR01087 100 VPLPVVAITGTNGKTTTTSLLYHLLKAAGLKAFLGGN----IGTP--ALEVLDQEGAELYVLELSSF-QLETTESLR-PE 171
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 180 VVIINNAGTAHVGEFGGPDKIVEAKGEILEGLGQGGIAILNLDDKAFDIWKARAGAHKVVSFARSNpkadfHASDIGRDA 259
Cdd:TIGR01087 172 IALILNISEDHLDWHGSFEDYVAAKLKIFARQTEGDVAVLNADDPRFARLAQKSKAQVIWFSVEKD-----AERGLCIRD 246
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 260 RGcpsFTLHGAGETVavqlNVLGEHNVSNALAAAAAAHAVGLSLSGIAAGLAAVQPVKGR--TVAQIapNGVRVIDDSYN 337
Cdd:TIGR01087 247 GG---LYLKPNDLEG----SLLGLHNAENILAAIALAKSLGLNLEAILEALRSFKGLPHRleYVGQK--NGVHFYNDSKA 317
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 338 ANPTSMCAAidiLAGFSGRTVLVLGDIGElgqwaEEGHRQVGDYARGKVDALYAVGSNmTHAVKAFGANGRHFATQAE-L 416
Cdd:TIGR01087 318 TNVHATLAA---LSAFDNPVILIVGGDDK-----GADFSPLAPAAAGKVKAVLAIGED-AAKIAPLLKEAGLSVYLVEsL 388
|
....*.
gi 499254911 417 IDAVSA 422
Cdd:TIGR01087 389 EEAVQA 394
|
|
| MurD |
COG0771 |
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; ... |
99-393 |
3.35e-21 |
|
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramoylalanine-D-glutamate ligase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440534 [Multi-domain] Cd Length: 445 Bit Score: 95.53 E-value: 3.35e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 99 AFDKPVVAITGSSGKTTVKEMLASILRTRGLVHATRGNLnndlGAP-LTLLEIAPEHSAAVIELgaS-----RIGEIRyt 172
Cdd:COG0771 102 LSPAPIIAITGTNGKTTTTTLIGHILKAAGLRVAVGGNI----GTPlLDLLLEPEPPDVYVLEL--SsfqleTTPSLR-- 173
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 173 vgltqPQVVIINNAGTAHVGEFGGPDKIVEAKGEILEGLGQGGIAILNLDDKAFDIWKARAGAhKVVSFARSNP-KADFH 251
Cdd:COG0771 174 -----PDVAVILNITPDHLDRHGSMEAYAAAKARIFANQTPDDYAVLNADDPLTRALAEEAKA-RVVPFSLKEPlEGGAG 247
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 252 ASD--IGRDARGCPSFTLHgagetvavQLNVLGEHNVSNALAAAAAAHAVGLSLSGIAAGLAAVQPVKGR--TVAQIapN 327
Cdd:COG0771 248 LEDgkLVDRASGEELLPVD--------DLRLPGRHNLENALAALAAARALGVPPEAIREALRSFKGLPHRleFVAEI--N 317
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 499254911 328 GVRVIDDSYNANPTSMCAAidiLAGFSGRTVLVLG------DIGELgqwaeeghrqvGDYARGKVDALYAVG 393
Cdd:COG0771 318 GVRFINDSKATNPDATLAA---LESFDGPVVLIAGgldkgaDFSPL-----------APAVAERVKAVVLIG 375
|
|
| MurC |
COG0773 |
UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall ... |
92-334 |
4.18e-17 |
|
UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440536 [Multi-domain] Cd Length: 451 Bit Score: 83.19 E-value: 4.18e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 92 LGALNRaafDKPVVAITGSSGKTTVKEMLASILRtrglvhatrgnlnnDLGAPLTlleiapehsaAVI-----ELGAS-R 165
Cdd:COG0773 97 LAELMR---GKRSIAVAGTHGKTTTTSMLAHILE--------------EAGLDPT----------FLIggilnNFGTNaR 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 166 IGEIRYTVG----------LTQPQVVIINNAGTAHVGEFGGPDKIVEAKGEILEGLGQGGIAILNLDDKAFDIWKARAGA 235
Cdd:COG0773 150 LGDGDYFVAeadesdgsflHYSPDIAVVTNIEADHLDIYGDLEAIKEAFHEFARNVPFYGLLVLCADDPGLRELLPRCGR 229
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 236 hKVVSFARsNPKADFHASDIGRDARGcPSFTLHGAGETVA-VQLNVLGEHNVSNALAAAAAAHAVGLSLSGIAAGLAAVQ 314
Cdd:COG0773 230 -PVITYGF-SEDADYRAENIRIDGGG-STFDVLRRGEELGeVELNLPGRHNVLNALAAIAVALELGVDPEAIAEALASFK 306
|
250 260
....*....|....*....|
gi 499254911 315 PVKGRTVAQIAPNGVRVIDD 334
Cdd:COG0773 307 GVKRRFELKGEVGGVTVIDD 326
|
|
| murC |
TIGR01082 |
UDP-N-acetylmuramate--L-alanine ligase; This model describes the MurC protein in bacterial ... |
92-347 |
1.14e-16 |
|
UDP-N-acetylmuramate--L-alanine ligase; This model describes the MurC protein in bacterial peptidoglycan (murein) biosynthesis. In a few species (Mycobacterium leprae, the Chlamydia), the amino acid may be L-serine or glycine instead of L-alanine. A related protein, UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase (murein tripeptide ligase) is described by model TIGR01081. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273433 [Multi-domain] Cd Length: 448 Bit Score: 81.97 E-value: 1.14e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 92 LGALNRAafdKPVVAITGSSGKTTVKEMLASILRTRGLV-------HATRGNLNNDLGAPLTLLEIAPEHSAAVIELgas 164
Cdd:TIGR01082 92 LAELMRF---RHSIAVAGTHGKTTTTAMIAVILKEAGLDptvvvggLVKEAGTNARLGSGEYLVAEADESDASFLHL--- 165
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 165 rigeirytvgltQPQVVIINNAGTAHVGEFGGP-DKIVEAKGEILEGLGQGGIAILNLDDKAFDIWKARAGaHKVVSFAR 243
Cdd:TIGR01082 166 ------------QPNVAIVTNIEPDHLDTYGSSfERLKAAFEKFIHNLPFYGLAVICADDPVLRELVPKAT-EQVITYGG 232
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 244 SNPKADFHASDIGRDARGcPSFTLHGAG-ETVAVQLNVLGEHNVSNALAAAAAAHAVGLSLSGIAAGLAAVQPVKGR--T 320
Cdd:TIGR01082 233 SGEDADYRAENIQQSGAE-GKFSVRGKGkLYLEFTLNLPGRHNVLNALAAIAVALELGIDFEAILRALANFQGVKRRfeI 311
|
250 260
....*....|....*....|....*..
gi 499254911 321 VAQIapNGVRVIDDsYNANPTSMCAAI 347
Cdd:TIGR01082 312 LGEF--GGVLLIDD-YAHHPTEIKATL 335
|
|
| murD |
PRK14106 |
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional |
102-362 |
1.67e-14 |
|
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional
Pssm-ID: 184511 [Multi-domain] Cd Length: 450 Bit Score: 75.01 E-value: 1.67e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 102 KPVVAITGSSGKTTVKEMLASILRTRGLVHATRGNLnndlGAPL-TLLEIAPEHSAAVIELGASRIGEIRYTvgltQPQV 180
Cdd:PRK14106 108 APIVAITGTNGKTTTTTLLGEIFKNAGRKTLVAGNI----GYPLiDAVEEYGEDDIIVAEVSSFQLETIKEF----KPKV 179
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 181 VIINNAGTAHVGEFGGPDKIVEAKGEILEGLGQGGIAILNLDDKAFDIWKARAGAhKVVSFARsnpKADFHASDIGRDAR 260
Cdd:PRK14106 180 GCILNITPDHLDRHKTMENYIKAKARIFENQRPSDYTVLNYDDPRTRSLAKKAKA-RVIFFSR---KSLLEEGVFVKNGK 255
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 261 gcpsFTLHGAGETVAV----QLNVLGEHNVSNALAAAAAAHAVGLSLSGIAAGLAAVQPVKGRT--VAQIapNGVRVIDD 334
Cdd:PRK14106 256 ----IVISLGGKEEEVididEIFIPGEHNLENALAATAAAYLLGISPDVIANTLKTFKGVEHRIefVAEI--NGVKFIND 329
|
250 260
....*....|....*....|....*...
gi 499254911 335 SYNANPTsmcAAIDILAGFSGRTVLVLG 362
Cdd:PRK14106 330 SKGTNPD---AAIKALEAYETPIVLIAG 354
|
|
| PRK14022 |
PRK14022 |
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase; |
21-369 |
1.41e-13 |
|
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase;
Pssm-ID: 237588 [Multi-domain] Cd Length: 481 Bit Score: 72.38 E-value: 1.41e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 21 GDATFTGVSIDSRSVSAGQLFVAlAGPRFDgHDYLADVKAKGAVAALVEREVaDVDLPQLQVADCRLALGQLGalnRAAF 100
Cdd:PRK14022 30 SGVQFDDISYDSRTADEGTLFFA-KGAYFK-HKFLQNAITQGLKLYVSEKDY-EVGIPQVIVPDIKKAMSLIA---MEFY 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 101 DKP-----VVAITGSSGKTTVKEMLASILRTRG---LVHATRGNLNND------LGAPLTLLEIApeHSAAVIELGA-SR 165
Cdd:PRK14022 104 DNPqhklkLLAFTGTKGKTTAAYFAYHILKQLHkpaMLSTMNTTLDGEtffksaLTTPESLDLFK--MMAEAVDNGMtHL 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 166 IGEIR---YTV----GLTQpQVVIINNAGTAHVG--EFGGPDKIVEAKGEILEglgQGGIAILNLDDKAFDIWKARAgAH 236
Cdd:PRK14022 182 IMEVSsqaYLVgrvyGLTF-DVGVFLNITPDHIGpiEHPTFEDYFYHKRLLME---NSKAVVVNSDMDHFSELLEQV-TP 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 237 KVVSFARSNPKADFHASDigrdargcpSFTLHGAGE---TVAVQLnvLGEHNVSNALAAAAAAHAVGLSLSGIAAGLAAv 313
Cdd:PRK14022 257 QEHDFYGIDSENQIMASN---------AFSFEATGKlagTYDIQL--IGKFNQENAMAAGLACLRLGASLEDIQKGIAQ- 324
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 499254911 314 QPVKGRTVAQIAPNGVRVIDDsYNANPTSMCAAIDILAGF-SGRTVLVLGDIGELGQ 369
Cdd:PRK14022 325 TPVPGRMEVLTQSNGAKVFID-YAHNGDSLNKLIDVVEEHqKGKLILLLGAAGNKGE 380
|
|
| Mur_ligase |
pfam01225 |
Mur ligase family, catalytic domain; This family contains a number of related ligase enzymes ... |
24-94 |
4.02e-11 |
|
Mur ligase family, catalytic domain; This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC, MurD, MurE, MurF, Mpl and FolC. MurC, MurD, Mure and MurF catalyze consecutive steps in the synthesis of peptidoglycan. Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide. The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine. The peptide moiety is synthesized by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate.
Pssm-ID: 460121 [Multi-domain] Cd Length: 84 Bit Score: 58.78 E-value: 4.02e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 24 TFTGVSIDSRSVSAGQLFVALAGPRFDGHDYLADVKAKGAVAALVER----------EVADVDLPQLQVADCRLALGQLG 93
Cdd:pfam01225 1 EIHFVGIDGRGMSPGALFLALKGYRVDGSDFIESLIALGAAAVVGHDaannispdnpELEAAKVPGIPVIDRREALAELA 80
|
.
gi 499254911 94 A 94
Cdd:pfam01225 81 A 81
|
|
| F430_CfbE |
NF033197 |
coenzyme F430 synthase; Members of this family are coenzyme F430 synthase, involving in ... |
88-373 |
4.33e-09 |
|
coenzyme F430 synthase; Members of this family are coenzyme F430 synthase, involving in synthesizing coenzyme F430, which is used in methanogens by coenzyme M reductase. Members of this family are restricted to archaeal methanogens, and resemble (and may be misannotated as) MurD, an enzyme of bacterial cell wall biosynthesis.
Pssm-ID: 467992 [Multi-domain] Cd Length: 419 Bit Score: 58.11 E-value: 4.33e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 88 ALGQLGALNRAAFDKPVVAITGSSGKTTVKEMLASILRTR-GLVHATRGNLNNDLGAPLTLLEIAPehsAAVIEL--GAS 164
Cdd:NF033197 78 AVGEILKKKYGRIPKKFIEITGVKGKTTTAELLAHILSDEyVLLHTSRGTERYPEGELSNKGSITP---ASILNAleLAE 154
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 165 RIGEIRYTvgltqpqvviinnagtahvgefggpDKIVEakgEILEGLGQGGIAIL-NLDDKaFDIWKAR--AGAHKVVSF 241
Cdd:NF033197 155 EIGIDDYG-------------------------FLIFE---VSLGGTGAGDVGIItNILED-YPIAGGKrsASAAKLQSL 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 242 ARS--------NPKADFHASDI----GRDARGCPSFTLHGAGETVAVQLN--VLGEHNVSNALAAAAAAHAVGLSLSGIA 307
Cdd:NF033197 206 KNAkvgsinvaDLGIYINGKNKlvitVAGVEILSKYPLRFKYGNTEFEFNplLFGPHYRENSLFAIEAALNLGVDPEDII 285
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 499254911 308 AGLAAVQPVKGRT-VAQIapNGVRVIDdsyNANP----TSMCAAIDILAGFSGRTVLVLGdiGELGQWAEE 373
Cdd:NF033197 286 SALKGFKGLPGRMaVKKE--GGVVIVD---NINPglnvKAIEYALDDALELLGDGTLVIG--GDFGVVCEE 349
|
|
| Mur_ligase_C |
pfam02875 |
Mur ligase family, glutamate ligase domain; This family contains a number of related ligase ... |
327-370 |
1.35e-06 |
|
Mur ligase family, glutamate ligase domain; This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC, MurD, MurE, MurF, Mpl and FolC. MurC, MurD, Mure and MurF catalyze consecutive steps in the synthesis of peptidoglycan. Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide. The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine. The peptide moiety is synthesized by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate.
Pssm-ID: 460731 [Multi-domain] Cd Length: 87 Bit Score: 46.18 E-value: 1.35e-06
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 499254911 327 NGVRVIDDsYNANPTSMCAAIDILAG-FSGRTVLVLGDIGELGQW 370
Cdd:pfam02875 12 NGVLVIDD-YAHNPDAMEAALRALRNlFPGRLILVFGGMGDRDAE 55
|
|
| PRK14016 |
PRK14016 |
cyanophycin synthetase; Provisional |
103-223 |
7.28e-06 |
|
cyanophycin synthetase; Provisional
Pssm-ID: 237586 [Multi-domain] Cd Length: 727 Bit Score: 48.61 E-value: 7.28e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499254911 103 PVVAITGSSGKTTVKEMLASILRTRGLV--------------HATRGNLNNDLGAPLTLLEiaPEHSAAVIELGasRIGE 168
Cdd:PRK14016 481 PIVAVTGTNGKTTTTRLIAHILKLSGKRvgmtttdgvyidgrLIDKGDCTGPKSARRVLMN--PDVEAAVLETA--RGGI 556
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 499254911 169 IRYTVGLTQPQVVIINNAGTAHVGEFG--GPDKIVEAKGEILEGLGQGGIAILNLDD 223
Cdd:PRK14016 557 LREGLAYDRCDVGVVTNIGEDHLGLGGinTLEDLAKVKRVVVEAVKPDGYAVLNADD 613
|
|
| |
