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Conserved domains on  [gi|499273404|ref|WP_010970797|]
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MULTISPECIES: RsmB/NOP family class I SAM-dependent RNA methyltransferase [Agrobacterium tumefaciens complex]

Protein Classification

RsmB/NOP family class I SAM-dependent RNA methyltransferase( domain architecture ID 11414805)

RsmB/NOP family class I SAM-dependent RNA methyltransferase similar to tRNA (cytosine(34)-C(5))-methyltransferase, which methylates cytosine at specific positions of intron-containing tRNA(Leu)(CAA) precursors and tRNA(Gly)(GCC) precursors

CATH:  2.20.25.110
EC:  2.1.1.-
Gene Ontology:  GO:0003723
PubMed:  12504684|12826405
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RsmB COG0144
16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and ...
 6-429 1.22e-130

16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family is part of the Pathway/BioSystem: 16S rRNA modification


:

Pssm-ID: 439914 [Multi-domain]  Cd Length: 441  Bit Score: 383.59  E-value: 1.22e-130
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499273404   6 RLAGAIEVLADIEGRRRPVADALKDWGLAHRFAGSGDRAAIGNIVYDALRMKLSHAWLMDDDSAASLAYAVLLRQWGKSF 85
Cdd:COG0144   24 LLALLLLDRALAALLLLAALRLLRRRDRALLAALLAGLLRLLRLLLLLLRLLLLLLLLLLLPLLAALLLVAAAQLLAARV 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499273404  86 AELTAEFDG-DKFAPAA--PDAERQQAFLSRSLSDAPAYIQGDVPEWVQSSLETAFG-ERWLAEAQALNERPTLDLRANT 161
Cdd:COG0144  104 AVDEAVGPGaAGLVNAVlrRVLREREALLAAADPVERLAVRYSHPEWLVERLRAAYGpEEAEALLAALNEPPPLDLRVNT 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499273404 162 LKATRDKVLKALEESG--AEATRIARQGLRIPAGEGPSRLPnvtaelSFQKGWFEVQDEGSQIVADLAGAREGEQVLDYC 239
Cdd:COG0144  184 LKASREELLARLAEEGieAEPTPLSPDGLRLEGPGPVTALP------GFREGLFSVQDEASQLVALLLDPKPGERVLDLC 257

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499273404 240 AGGGGKTLAMAASMNNKGQVHAFDADRKRLAPIIERLKRAGTRNVQVH--DRAAGLAPFQEKFDRVLVDAPCTGTGTWRR 317
Cdd:COG0144  258 AAPGGKTLHLAELMGNKGRVVAVDISEHRLKRLRENLARLGLSNVEVVvaDARELLEWLPGKFDRVLLDAPCSGTGTLRR 337

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499273404 318 RPDTKWRLTARNLEERVQQQGEALSQAKGFVRPGGELLYVTCSVLPEENEQQVRRFCEENPEFAIGSALERWQSIFsgna 397
Cdd:COG0144  338 HPDIKWRRTPEDIAELAALQRELLDAAARLLKPGGRLVYSTCSLLPEENEEVVEAFLARHPDFELVPLAELLPGLA---- 413

                        410       420       430
                 ....*....|....*....|....*....|..
gi 499273404 398 nkphSSDGKTVTLTPATTDTDGFFFCLMKRKA 429
Cdd:COG0144  414 ----LTDGGYLRLLPHRHGTDGFFIARLRKKA 441
 
Name Accession Description Interval E-value
RsmB COG0144
16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and ...
 6-429 1.22e-130

16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 439914 [Multi-domain]  Cd Length: 441  Bit Score: 383.59  E-value: 1.22e-130
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499273404   6 RLAGAIEVLADIEGRRRPVADALKDWGLAHRFAGSGDRAAIGNIVYDALRMKLSHAWLMDDDSAASLAYAVLLRQWGKSF 85
Cdd:COG0144   24 LLALLLLDRALAALLLLAALRLLRRRDRALLAALLAGLLRLLRLLLLLLRLLLLLLLLLLLPLLAALLLVAAAQLLAARV 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499273404  86 AELTAEFDG-DKFAPAA--PDAERQQAFLSRSLSDAPAYIQGDVPEWVQSSLETAFG-ERWLAEAQALNERPTLDLRANT 161
Cdd:COG0144  104 AVDEAVGPGaAGLVNAVlrRVLREREALLAAADPVERLAVRYSHPEWLVERLRAAYGpEEAEALLAALNEPPPLDLRVNT 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499273404 162 LKATRDKVLKALEESG--AEATRIARQGLRIPAGEGPSRLPnvtaelSFQKGWFEVQDEGSQIVADLAGAREGEQVLDYC 239
Cdd:COG0144  184 LKASREELLARLAEEGieAEPTPLSPDGLRLEGPGPVTALP------GFREGLFSVQDEASQLVALLLDPKPGERVLDLC 257

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499273404 240 AGGGGKTLAMAASMNNKGQVHAFDADRKRLAPIIERLKRAGTRNVQVH--DRAAGLAPFQEKFDRVLVDAPCTGTGTWRR 317
Cdd:COG0144  258 AAPGGKTLHLAELMGNKGRVVAVDISEHRLKRLRENLARLGLSNVEVVvaDARELLEWLPGKFDRVLLDAPCSGTGTLRR 337

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499273404 318 RPDTKWRLTARNLEERVQQQGEALSQAKGFVRPGGELLYVTCSVLPEENEQQVRRFCEENPEFAIGSALERWQSIFsgna 397
Cdd:COG0144  338 HPDIKWRRTPEDIAELAALQRELLDAAARLLKPGGRLVYSTCSLLPEENEEVVEAFLARHPDFELVPLAELLPGLA---- 413

                        410       420       430
                 ....*....|....*....|....*....|..
gi 499273404 398 nkphSSDGKTVTLTPATTDTDGFFFCLMKRKA 429
Cdd:COG0144  414 ----LTDGGYLRLLPHRHGTDGFFIARLRKKA 441
PRK14902 PRK14902
16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB;
126-428 4.72e-81

16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB;


Pssm-ID: 237857 [Multi-domain]  Cd Length: 444  Bit Score: 256.64  E-value: 4.72e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499273404 126 VPEWVQSSLETAFG-ERWLAEAQALNERPTLDLRANTLKATRDKVLKALEESG--AEATRIARQGLRIPAGegpsrlpNV 202
Cdd:PRK14902 149 HPVWLVKRWIDQYGeEKAEKILESLNEPPKASIRVNTLKISVEELIEKLEEEGyeVEESLLSPEALVIEKG-------NI 221

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499273404 203 TAELSFQKGWFEVQDEGSQIVADLAGAREGEQVLDYCAGGGGKTLAMAASMNNKGQVHAFDADRKRLAPIIERLKRAGTR 282
Cdd:PRK14902 222 AGTDLFKDGLITIQDESSMLVAPALDPKGGDTVLDACAAPGGKTTHIAELLKNTGKVVALDIHEHKLKLIEENAKRLGLT 301

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499273404 283 NV--QVHDrAAGLAP-FQEKFDRVLVDAPCTGTGTWRRRPDTKWRLTARNLEERVQQQGEALSQAKGFVRPGGELLYVTC 359
Cdd:PRK14902 302 NIetKALD-ARKVHEkFAEKFDKILVDAPCSGLGVIRRKPDIKYNKTKEDIESLQEIQLEILESVAQYLKKGGILVYSTC 380

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499273404 360 SVLPEENEQQVRRFCEENPEFaigsaleRWQSIFSGNA-NKPHSSDGKTVTLTPATTDTDGFFFCLMKRK 428
Cdd:PRK14902 381 TIEKEENEEVIEAFLEEHPEF-------ELVPLQHEKPdELVYEVKDGYLQILPNDYGTDGFFIAKLRKK 443
rsmB TIGR00563
16S rRNA (cytosine(967)-C(5))-methyltransferase; This protein is also known as sun protein. ...
 127-428 4.21e-59

16S rRNA (cytosine(967)-C(5))-methyltransferase; This protein is also known as sun protein. The reading frame was originally interpreted as two reading frames, fmu and fmv. The recombinant protein from E. coli was shown to methylate only C967 of small subunit (16S) ribosomal RNA and to produce only m5C at that position. The seed alignment is built from bacterial sequences only. Eukaryotic homologs include Nop2, a protein required for processing pre-rRNA, that is likely also a rRNA methyltransferase, although the fine specificity may differ. Cutoff scores are set to avoid treating archaeal and eukaroytic homologs automatically as functionally equivalent, although they may have very similar roles. [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 273141 [Multi-domain]  Cd Length: 426  Bit Score: 198.94  E-value: 4.21e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499273404  127 PEWVQSSLETAFGERWLAEAQALNERPTLDLRANTLKATRDKVLKALEESG--AEATRIARQGLRIPAGEGPSRLPNvta 204
Cdd:TIGR00563 138 PEWLVKRLQKAYPGQWQSICEANNQRPPMWLRINRTKHSRDEWLALLAEAGmkGFPHDLAPDAVRLETPAAVHALPG--- 214

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499273404  205 elsFQKGWFEVQDEGSQIVADLAGAREGEQVLDYCAGGGGKTLAMAASMNnKGQVHAFDADRKRLAPIIERLKRAG-TRN 283
Cdd:TIGR00563 215 ---FEEGWVTVQDASAQWVATWLAPQNEETILDACAAPGGKTTHILELAP-QAQVVALDIHEHRLKRVYENLKRLGlTIK 290

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499273404  284 VQVHD-RAAGLAPFQE--KFDRVLVDAPCTGTGTWRRRPDTKWRLTARNLEERVQQQGEALSQAKGFVRPGGELLYVTCS 360
Cdd:TIGR00563 291 AETKDgDGRGPSQWAEneQFDRILLDAPCSATGVIRRHPDIKWLRKPRDIAELAELQSEILDAIWPLLKTGGTLVYATCS 370

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 499273404  361 VLPEENEQQVRRFCEENPEFAIGSALERWQSIFSGNANKPHSSDGktvtltpattdtDGFFFCLMKRK 428
Cdd:TIGR00563 371 VLPEENSEQIKAFLQEHPDFPFEKTGTPEQVRDGGLQILPHAEEG------------DGFFYAKLIKK 426
Methyltr_RsmB-F pfam01189
16S rRNA methyltransferase RsmB/F; This is the catalytic core of this SAM-dependent 16S ...
 230-426 8.72e-47

16S rRNA methyltransferase RsmB/F; This is the catalytic core of this SAM-dependent 16S ribosomal methyltransferase RsmB/F enzyme. There is a catalytic cysteine residue at 180 in UniProtKB:Q5SII2, with another highly conserved cysteine at residue 230. It methylates the C(5) position of cytosine 2870 (m5C2870) in 25S rRNA.


Pssm-ID: 426109 [Multi-domain]  Cd Length: 199  Bit Score: 159.51  E-value: 8.72e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499273404  230 REGEQVLDYCAGGGGKTLAMAASMNNKGQVHAFDADRKRLAPIIERLKRAGTRNVQVHD---RAAGLAPFQEKFDRVLVD 306
Cdd:pfam01189   7 QEGETILDMCAAPGGKTTHIAELMKNQGTVVAVDINKHRLKRVAENIHRLGVTNTIILNgdgRQPDQWLGGVLFDRILLD 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499273404  307 APCTGTGTWRRRPDTKWRLTARNLEERVQQQGEALSQAKGFVRPGGELLYVTCSVLPEENEQQVRRFCEENPEFAIgsaL 386
Cdd:pfam01189  87 APCSGTGVIRRHPDVKWLRQEADIAQLAQLQKELLSAAIDLLKPGGVLVYSTCSVLPEENEAVIEYFLQKHPDVEL---V 163

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 499273404  387 ERWQSIFSGNANKphssDGKTVTLTPATTDTDGFFFCLMK 426
Cdd:pfam01189 164 PTPLFEPVGLAIG----EQPTLRLLPHTHNGDGFFIAKLR 199
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 235-309 6.92e-04

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 38.95  E-value: 6.92e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 499273404 235 VLDYCAGGGGKTLAMAAsmNNKGQVHAFDADRKRLAPIIERLKRAGTRNVQVHDRAAGLAPFQ--EKFDRVLVDAPC 309
Cdd:cd02440    2 VLDLGCGTGALALALAS--GPGARVTGVDISPVALELARKAAAALLADNVEVLKGDAEELPPEadESFDVIISDPPL 76
 
Name Accession Description Interval E-value
RsmB COG0144
16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and ...
 6-429 1.22e-130

16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 439914 [Multi-domain]  Cd Length: 441  Bit Score: 383.59  E-value: 1.22e-130
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499273404   6 RLAGAIEVLADIEGRRRPVADALKDWGLAHRFAGSGDRAAIGNIVYDALRMKLSHAWLMDDDSAASLAYAVLLRQWGKSF 85
Cdd:COG0144   24 LLALLLLDRALAALLLLAALRLLRRRDRALLAALLAGLLRLLRLLLLLLRLLLLLLLLLLLPLLAALLLVAAAQLLAARV 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499273404  86 AELTAEFDG-DKFAPAA--PDAERQQAFLSRSLSDAPAYIQGDVPEWVQSSLETAFG-ERWLAEAQALNERPTLDLRANT 161
Cdd:COG0144  104 AVDEAVGPGaAGLVNAVlrRVLREREALLAAADPVERLAVRYSHPEWLVERLRAAYGpEEAEALLAALNEPPPLDLRVNT 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499273404 162 LKATRDKVLKALEESG--AEATRIARQGLRIPAGEGPSRLPnvtaelSFQKGWFEVQDEGSQIVADLAGAREGEQVLDYC 239
Cdd:COG0144  184 LKASREELLARLAEEGieAEPTPLSPDGLRLEGPGPVTALP------GFREGLFSVQDEASQLVALLLDPKPGERVLDLC 257

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499273404 240 AGGGGKTLAMAASMNNKGQVHAFDADRKRLAPIIERLKRAGTRNVQVH--DRAAGLAPFQEKFDRVLVDAPCTGTGTWRR 317
Cdd:COG0144  258 AAPGGKTLHLAELMGNKGRVVAVDISEHRLKRLRENLARLGLSNVEVVvaDARELLEWLPGKFDRVLLDAPCSGTGTLRR 337

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499273404 318 RPDTKWRLTARNLEERVQQQGEALSQAKGFVRPGGELLYVTCSVLPEENEQQVRRFCEENPEFAIGSALERWQSIFsgna 397
Cdd:COG0144  338 HPDIKWRRTPEDIAELAALQRELLDAAARLLKPGGRLVYSTCSLLPEENEEVVEAFLARHPDFELVPLAELLPGLA---- 413

                        410       420       430
                 ....*....|....*....|....*....|..
gi 499273404 398 nkphSSDGKTVTLTPATTDTDGFFFCLMKRKA 429
Cdd:COG0144  414 ----LTDGGYLRLLPHRHGTDGFFIARLRKKA 441
PRK14902 PRK14902
16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB;
126-428 4.72e-81

16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB;


Pssm-ID: 237857 [Multi-domain]  Cd Length: 444  Bit Score: 256.64  E-value: 4.72e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499273404 126 VPEWVQSSLETAFG-ERWLAEAQALNERPTLDLRANTLKATRDKVLKALEESG--AEATRIARQGLRIPAGegpsrlpNV 202
Cdd:PRK14902 149 HPVWLVKRWIDQYGeEKAEKILESLNEPPKASIRVNTLKISVEELIEKLEEEGyeVEESLLSPEALVIEKG-------NI 221

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499273404 203 TAELSFQKGWFEVQDEGSQIVADLAGAREGEQVLDYCAGGGGKTLAMAASMNNKGQVHAFDADRKRLAPIIERLKRAGTR 282
Cdd:PRK14902 222 AGTDLFKDGLITIQDESSMLVAPALDPKGGDTVLDACAAPGGKTTHIAELLKNTGKVVALDIHEHKLKLIEENAKRLGLT 301

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499273404 283 NV--QVHDrAAGLAP-FQEKFDRVLVDAPCTGTGTWRRRPDTKWRLTARNLEERVQQQGEALSQAKGFVRPGGELLYVTC 359
Cdd:PRK14902 302 NIetKALD-ARKVHEkFAEKFDKILVDAPCSGLGVIRRKPDIKYNKTKEDIESLQEIQLEILESVAQYLKKGGILVYSTC 380

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499273404 360 SVLPEENEQQVRRFCEENPEFaigsaleRWQSIFSGNA-NKPHSSDGKTVTLTPATTDTDGFFFCLMKRK 428
Cdd:PRK14902 381 TIEKEENEEVIEAFLEEHPEF-------ELVPLQHEKPdELVYEVKDGYLQILPNDYGTDGFFIAKLRKK 443
PRK14901 PRK14901
16S rRNA methyltransferase B; Provisional
 127-429 8.82e-65

16S rRNA methyltransferase B; Provisional


Pssm-ID: 237856 [Multi-domain]  Cd Length: 434  Bit Score: 214.02  E-value: 8.82e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499273404 127 PEWVQSSLETAFGerwLAEA----QALNERPTLDLRANTLKATRDKVLKALEESGAEATRIAR--QGLRIPAGEGPSR-L 199
Cdd:PRK14901 150 PDWLVKLWLEWLG---LEEAeqlcKWFNQPPSLDLRINPLRTSLEEVQAALAEAGITATPIPGlpQGLRLTGNPGSIRqL 226

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499273404 200 PnvtaelSFQKGWFEVQDEGSQIVADLAGAREGEQVLDYCAGGGGKTLAMAASMNNKGQVHAFDADRKRLAPIIERLKRA 279
Cdd:PRK14901 227 P------GYEEGWWTVQDRSAQLVAPLLDPQPGEVILDACAAPGGKTTHIAELMGDQGEIWAVDRSASRLKKLQENAQRL 300

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499273404 280 GTRNVQVH-----DRAAGLAPFQEKFDRVLVDAPCTGTGTWRRRPDTKWRLTARNLEERVQQQGEALSQAKGFVRPGGEL 354
Cdd:PRK14901 301 GLKSIKILaadsrNLLELKPQWRGYFDRILLDAPCSGLGTLHRHPDARWRQTPEKIQELAPLQAELLESLAPLLKPGGTL 380

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 499273404 355 LYVTCSVLPEENEQQVRRFCEENPEFAIGS-ALERWqsifsgnankPHSSDGktvtltpattdtDGFFFCLMKRKA 429
Cdd:PRK14901 381 VYATCTLHPAENEAQIEQFLARHPDWKLEPpKQKIW----------PHRQDG------------DGFFMAVLRKKS 434
PRK10901 PRK10901
16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB;
106-426 9.85e-64

16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB;


Pssm-ID: 236790 [Multi-domain]  Cd Length: 427  Bit Score: 210.82  E-value: 9.85e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499273404 106 RQQAFLSRSLSDAPAyiQGDVPEWVQSSLETAFGERWLAEAQALNERPTLDLRANTLKATRDKVLKALEESG--AEATRI 183
Cdd:PRK10901 125 EQEELLAELQADPVA--RYNHPSWLIKRLKKAYPEQWQAILAANNQRPPMWLRVNRRHHSRDAYLALLAEAGieAFPHAV 202

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499273404 184 ARQGLRIPAGEGPSRLPNvtaelsFQKGWFEVQDEGSQIVADLAGAREGEQVLDYCAGGGGKT-----LAMAAsmnnkgQ 258
Cdd:PRK10901 203 GPDAIRLETPVPVHQLPG------FAEGWVSVQDAAAQLAATLLAPQNGERVLDACAAPGGKTahileLAPQA------Q 270

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499273404 259 VHAFDADRKRLAPIIERLKRAG-TRNVQVHDrAAGLAPFQ--EKFDRVLVDAPCTGTGTWRRRPDTKWRLTARNLEERVQ 335
Cdd:PRK10901 271 VVALDIDAQRLERVRENLQRLGlKATVIVGD-ARDPAQWWdgQPFDRILLDAPCSATGVIRRHPDIKWLRRPEDIAALAA 349

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499273404 336 QQGEALSQAKGFVRPGGELLYVTCSVLPEENEQQVRRFCEENPEfaigSALERWqsifsGNANKPHssdgktVTLTPATT 415
Cdd:PRK10901 350 LQSEILDALWPLLKPGGTLLYATCSILPEENEQQIKAFLARHPD----AELLDT-----GTPQQPG------RQLLPGEE 414

                        330
                 ....*....|.
gi 499273404 416 DTDGFFFCLMK 426
Cdd:PRK10901 415 DGDGFFYALLI 425
rsmB TIGR00563
16S rRNA (cytosine(967)-C(5))-methyltransferase; This protein is also known as sun protein. ...
 127-428 4.21e-59

16S rRNA (cytosine(967)-C(5))-methyltransferase; This protein is also known as sun protein. The reading frame was originally interpreted as two reading frames, fmu and fmv. The recombinant protein from E. coli was shown to methylate only C967 of small subunit (16S) ribosomal RNA and to produce only m5C at that position. The seed alignment is built from bacterial sequences only. Eukaryotic homologs include Nop2, a protein required for processing pre-rRNA, that is likely also a rRNA methyltransferase, although the fine specificity may differ. Cutoff scores are set to avoid treating archaeal and eukaroytic homologs automatically as functionally equivalent, although they may have very similar roles. [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 273141 [Multi-domain]  Cd Length: 426  Bit Score: 198.94  E-value: 4.21e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499273404  127 PEWVQSSLETAFGERWLAEAQALNERPTLDLRANTLKATRDKVLKALEESG--AEATRIARQGLRIPAGEGPSRLPNvta 204
Cdd:TIGR00563 138 PEWLVKRLQKAYPGQWQSICEANNQRPPMWLRINRTKHSRDEWLALLAEAGmkGFPHDLAPDAVRLETPAAVHALPG--- 214

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499273404  205 elsFQKGWFEVQDEGSQIVADLAGAREGEQVLDYCAGGGGKTLAMAASMNnKGQVHAFDADRKRLAPIIERLKRAG-TRN 283
Cdd:TIGR00563 215 ---FEEGWVTVQDASAQWVATWLAPQNEETILDACAAPGGKTTHILELAP-QAQVVALDIHEHRLKRVYENLKRLGlTIK 290

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499273404  284 VQVHD-RAAGLAPFQE--KFDRVLVDAPCTGTGTWRRRPDTKWRLTARNLEERVQQQGEALSQAKGFVRPGGELLYVTCS 360
Cdd:TIGR00563 291 AETKDgDGRGPSQWAEneQFDRILLDAPCSATGVIRRHPDIKWLRKPRDIAELAELQSEILDAIWPLLKTGGTLVYATCS 370

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 499273404  361 VLPEENEQQVRRFCEENPEFAIGSALERWQSIFSGNANKPHSSDGktvtltpattdtDGFFFCLMKRK 428
Cdd:TIGR00563 371 VLPEENSEQIKAFLQEHPDFPFEKTGTPEQVRDGGLQILPHAEEG------------DGFFYAKLIKK 426
Methyltr_RsmB-F pfam01189
16S rRNA methyltransferase RsmB/F; This is the catalytic core of this SAM-dependent 16S ...
 230-426 8.72e-47

16S rRNA methyltransferase RsmB/F; This is the catalytic core of this SAM-dependent 16S ribosomal methyltransferase RsmB/F enzyme. There is a catalytic cysteine residue at 180 in UniProtKB:Q5SII2, with another highly conserved cysteine at residue 230. It methylates the C(5) position of cytosine 2870 (m5C2870) in 25S rRNA.


Pssm-ID: 426109 [Multi-domain]  Cd Length: 199  Bit Score: 159.51  E-value: 8.72e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499273404  230 REGEQVLDYCAGGGGKTLAMAASMNNKGQVHAFDADRKRLAPIIERLKRAGTRNVQVHD---RAAGLAPFQEKFDRVLVD 306
Cdd:pfam01189   7 QEGETILDMCAAPGGKTTHIAELMKNQGTVVAVDINKHRLKRVAENIHRLGVTNTIILNgdgRQPDQWLGGVLFDRILLD 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499273404  307 APCTGTGTWRRRPDTKWRLTARNLEERVQQQGEALSQAKGFVRPGGELLYVTCSVLPEENEQQVRRFCEENPEFAIgsaL 386
Cdd:pfam01189  87 APCSGTGVIRRHPDVKWLRQEADIAQLAQLQKELLSAAIDLLKPGGVLVYSTCSVLPEENEAVIEYFLQKHPDVEL---V 163

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 499273404  387 ERWQSIFSGNANKphssDGKTVTLTPATTDTDGFFFCLMK 426
Cdd:pfam01189 164 PTPLFEPVGLAIG----EQPTLRLLPHTHNGDGFFIAKLR 199
PRK14904 PRK14904
16S rRNA methyltransferase B; Provisional
 127-429 4.73e-45

16S rRNA methyltransferase B; Provisional


Pssm-ID: 237858 [Multi-domain]  Cd Length: 445  Bit Score: 162.15  E-value: 4.73e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499273404 127 PEWVQssletafgERWLA-----EAQAL----NERPTLDLRANTLKATRDKVLKALEesGAEATRIarqglripagegPS 197
Cdd:PRK14904 152 PEWLL--------ERWIArygeeRTEAMlsynNQAPLFGFRINRLKTTPEKFLAAPA--DASVTFE------------KS 209

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499273404 198 RLPNVTAELSF-------QKGWFEVQDEGSQIVADLAGAREGEQVLDYCAGGGGKTLAMAASMNNKGQVHAFDADRKRLA 270
Cdd:PRK14904 210 GLPNFFLSKDFslfepflKLGLVSVQNPTQALACLLLNPQPGSTVLDLCAAPGGKSTFMAELMQNRGQITAVDRYPQKLE 289

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499273404 271 PIIERLKRAGTRNVQVHDRAAGLAPFQEKFDRVLVDAPCTGTGTWRRRPDTKWRLTARNLEERVQQQGEALSQAKGFVRP 350
Cdd:PRK14904 290 KIRSHASALGITIIETIEGDARSFSPEEQPDAILLDAPCTGTGVLGRRAELRWKLTPEKLAELVGLQAELLDHAASLLKP 369

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 499273404 351 GGELLYVTCSVLPEENEQQVRRFCEENPEFAIGSALERWQSIFSGNAnkphSSDGKTVTLTPATTDTDGFFFCLMKRKA 429
Cdd:PRK14904 370 GGVLVYATCSIEPEENELQIEAFLQRHPEFSAEPSPGSLPEPFHEVA----HPKGAILTLPGEHEGFDGGFAQRLRKNA 444
nop2p TIGR00446
NOL1/NOP2/sun family putative RNA methylase; [Protein synthesis, tRNA and rRNA base ...
 157-421 3.59e-37

NOL1/NOP2/sun family putative RNA methylase; [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 188051 [Multi-domain]  Cd Length: 264  Bit Score: 136.44  E-value: 3.59e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499273404  157 LRANTLKATRDKVLKALEESGAEATRIARQGLrIPAGEGPSRLpNVTAElsFQKGWFEVQDEGSQIVADLAGAREGEQVL 236
Cdd:TIGR00446   1 IRVNTLKINVEDLLERLENRGVVLEPTCEEYF-FEVKESPFSI-GSTPE--YLFGYYYPQEASSMIPPIALEPREDERVL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499273404  237 DYCAGGGGKTLAMAASMNNKGQVHAFDADRKRLAPIIERLKRAGTRNVQV-HDRAAGLAPFQEKFDRVLVDAPCTGTGTW 315
Cdd:TIGR00446  77 DMAAAPGGKTTQISQLMKNKGCIVANEISKSRTKALISNINRMGVLNTIViNADGRKFGAYLLKFDAILLDAPCSGEGVI 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499273404  316 RRRPDTKWRLTARNLEERVQQQGEALSQAKGFVRPGGELLYVTCSVLPEENEQQVRRFCEENPefAIGSALERWQSIFSG 395
Cdd:TIGR00446 157 RKDPSRKRNWSEEDIKYCSLLQKELIDAAIDALKPGGVLVYSTCSLEVEENEEVIDYILRKRP--DVVEEIIKGDEFFGI 234

                         250       260
                  ....*....|....*....|....*.
gi 499273404  396 NANKPHSSdgKTVTLTPATTDTDGFF 421
Cdd:TIGR00446 235 NIGKGEVK--GALRVFPQNYDCEGFF 258
PRK14903 PRK14903
16S rRNA methyltransferase B; Provisional
 127-378 2.13e-35

16S rRNA methyltransferase B; Provisional


Pssm-ID: 184896 [Multi-domain]  Cd Length: 431  Bit Score: 135.39  E-value: 2.13e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499273404 127 PEWVQSSLETAFGERWLAEAQALNERP-TLDLRANTLKATRDKVLKALEESGAEATriarQGLRIPAGEGPSRLPNVTAE 205
Cdd:PRK14903 135 PKWLVNYWRSFLPEEAVLRIMEWNQEPlPTMLRVNSLAITREEVIKILAEEGTEAV----PGKHSPFSLIVRKLGVNMND 210

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499273404 206 LS-FQKGWFEVQDEGSQIVADLAGAREGEQVLDYCAGGGGKTLAMAASMNNKGQVHAFDADRKRLAPIIERLKRAGTRNV 284
Cdd:PRK14903 211 SRvIKDGLATVQGESSQIVPLLMELEPGLRVLDTCAAPGGKTTAIAELMKDQGKILAVDISREKIQLVEKHAKRLKLSSI 290

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499273404 285 QVH-DRAAGLAPF-QEKFDRVLVDAPCTGTGTWRRRPDTKWRLTARNLEERVQQQGEALSQAKGFVRPGGELLYVTCSVL 362
Cdd:PRK14903 291 EIKiADAERLTEYvQDTFDRILVDAPCTSLGTARNHPEVLRRVNKEDFKKLSEIQLRIVSQAWKLLEKGGILLYSTCTVT 370

                        250
                 ....*....|....*.
gi 499273404 363 PEENEQQVRRFCEENP 378
Cdd:PRK14903 371 KEENTEVVKRFVYEQK 386
yebU PRK11933
rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed
 157-368 2.40e-16

rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed


Pssm-ID: 183387 [Multi-domain]  Cd Length: 470  Bit Score: 80.72  E-value: 2.40e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499273404 157 LRANTLKATRDKVLKALEESGAEATRI--ARQGLRIP-AGEGPSRLPNvTAE-LSfqkGWFEVQDEGSQ--IVADLAGAR 230
Cdd:PRK11933  37 IRVNTLKISVADFLQLMAPYGWTLTPIpwCEEGFWIErDDEDALPLGN-TAEhLS---GLFYIQEASSMlpVAALFADDN 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499273404 231 EGEQVLDYCAGGGGKTLAMAASMNNKGQVHA--FDADR-KRLAPIIERLkraGTRNVQV--HD-RAAGLAPFqEKFDRVL 304
Cdd:PRK11933 113 APQRVLDMAAAPGSKTTQIAALMNNQGAIVAneYSASRvKVLHANISRC---GVSNVALthFDgRVFGAALP-ETFDAIL 188

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 499273404 305 VDAPCTGTGTWRRRPDT--KWRLTArnLEERVQQQGEALSQAKGFVRPGGELLYVTCSVLPEENEQ 368
Cdd:PRK11933 189 LDAPCSGEGTVRKDPDAlkNWSPES--NLEIAATQRELIESAFHALKPGGTLVYSTCTLNREENQA 252
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 220-358 2.12e-06

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 47.64  E-value: 2.12e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499273404 220 SQIVADLAGAREGEQVLDYCAGGGGkTLAMAASMNnkGQVHAFDADRKRLAPIIERLKRAGTRNVQVHDRAAGLAPFQ-E 298
Cdd:COG1041   15 ARALVNLAGAKEGDTVLDPFCGTGT-ILIEAGLLG--RRVIGSDIDPKMVEGARENLEHYGYEDADVIRGDARDLPLAdE 91

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 499273404 299 KFDRVLVDAPcTGTGTwrrrpdtkwRLTARNLEERVQqqgEALSQAKGFVRPGGELLYVT 358
Cdd:COG1041   92 SVDAIVTDPP-YGRSS---------KISGEELLELYE---KALEEAARVLKPGGRVVIVT 138
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 221-366 5.87e-04

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 41.06  E-value: 5.87e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499273404 221 QIVADLAGAREGEQVLDYCAGGGGKTLAMAASMNnkGQVHAFDADRKRLAPIIERLKRAGTRNVQVH-DRAAGLAPF-QE 298
Cdd:COG0500   16 ALLALLERLPKGGRVLDLGCGTGRNLLALAARFG--GRVIGIDLSPEAIALARARAAKAGLGNVEFLvADLAELDPLpAE 93

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 499273404 299 KFDRVLvdapCTGTgtwrrrpdtkwrLTARNLEERVqqqgEALSQAKGFVRPGGeLLYVTCSVLPEEN 366
Cdd:COG0500   94 SFDLVV----AFGV------------LHHLPPEERE----ALLRELARALKPGG-VLLLSASDAAAAL 140
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 235-309 6.92e-04

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 38.95  E-value: 6.92e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 499273404 235 VLDYCAGGGGKTLAMAAsmNNKGQVHAFDADRKRLAPIIERLKRAGTRNVQVHDRAAGLAPFQ--EKFDRVLVDAPC 309
Cdd:cd02440    2 VLDLGCGTGALALALAS--GPGARVTGVDISPVALELARKAAAALLADNVEVLKGDAEELPPEadESFDVIISDPPL 76
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 223-360 1.72e-03

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 38.44  E-value: 1.72e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499273404 223 VADLAGAREGEQVLDYCAGGGGKTLAMAAsmnNKGQVHAFDADRKRLAPIIERLKRAGtRNVQVHDRAAGLAPFQ-EKFD 301
Cdd:COG2226   14 LLAALGLRPGARVLDLGCGTGRLALALAE---RGARVTGVDISPEMLELARERAAEAG-LNVEFVVGDAEDLPFPdGSFD 89

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 499273404 302 RVLVdapctgtgtwrrrpdtkwRLTARNLEERVQqqgeALSQAKGFVRPGGELLYVTCS 360
Cdd:COG2226   90 LVIS------------------SFVLHHLPDPER----ALAEIARVLKPGGRLVVVDFS 126
PRK08317 PRK08317
hypothetical protein; Provisional
 226-306 3.55e-03

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 38.76  E-value: 3.55e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499273404 226 LAGAREGEQVLDYCAGGGGKTLAMAASMNNKGQVHAFDADRKRLAPIIERLKrAGTRNVQ-VHDRAAGLaPFQ-EKFDRV 303
Cdd:PRK08317  14 LLAVQPGDRVLDVGCGPGNDARELARRVGPEGRVVGIDRSEAMLALAKERAA-GLGPNVEfVRGDADGL-PFPdGSFDAV 91


                 ...
gi 499273404 304 LVD 306
Cdd:PRK08317  92 RSD 94
TrmA COG2265
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ...
 221-308 5.64e-03

tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441866 [Multi-domain]  Cd Length: 377  Bit Score: 38.62  E-value: 5.64e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499273404 221 QIVADLAGAREGEQVLD-YCaGGGGKTLAMAAsmnNKGQVHAFDADrkrlAPIIERLKR----AGTRNVQVH----DRAA 291
Cdd:COG2265  223 AAALEWLDLTGGERVLDlYC-GVGTFALPLAR---RAKKVIGVEIV----PEAVEDAREnarlNGLKNVEFVagdlEEVL 294

                         90
                 ....*....|....*..
gi 499273404 292 GLAPFQEKFDRVLVDAP 308
Cdd:COG2265  295 PELLWGGRPDVVVLDPP 311
RmsH COG0275
16S rRNA C1402 N4-methylase RsmH [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 241-306 8.40e-03

16S rRNA C1402 N4-methylase RsmH [Translation, ribosomal structure and biogenesis]; 16S rRNA C1402 N4-methylase RsmH is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 440044  Cd Length: 312  Bit Score: 38.12  E-value: 8.40e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 499273404 241 GGGGKTLAMAASMNNKGQVHAFDADRKRLAPIIERLKRAGTRNVQVHDRAAGLAPF-----QEKFDRVLVD 306
Cdd:COG0275   33 GGGGHSRAILERLGPGGRLIGIDRDPDAIAAAKERLAEFGDRFTLVHGNFSELDEVlaelgIEKVDGILLD 103
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 235-352 9.66e-03

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 35.23  E-value: 9.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499273404  235 VLDYCAGGGGKTLAMAASMNnkGQVHAFDADRKRLAPIIERLKRAGTR-NVQVHDrAAGLAPFQEKFDRVLvdapCTGTG 313
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGG--ARVTGVDLSPEMLERARERAAEAGLNvEFVQGD-AEDLPFPDGSFDLVV----SSGVL 73

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 499273404  314 TWRRRPDTKwrltarnleervqqqgEALSQAKGFVRPGG 352
Cdd:pfam13649  74 HHLPDPDLE----------------AALREIARVLKPGG 96
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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