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Conserved domains on  [gi|499298471|ref|WP_010989421|]
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MULTISPECIES: XRE/MutR family transcriptional regulator [Listeria]

Protein Classification

XRE/MutR family transcriptional regulator( domain architecture ID 10054625)

XRE/MutR family transcriptional regulator similar to Streptococcus gordonii HTH-type transcriptional regulator rgg that regulates the expression of glucosyltransferase (gtfG)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RGG_Cterm TIGR01716
transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; This model describes the ...
 63-293 9.85e-66

transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; This model describes the whole, except for a 60 residue N-terminal helix-turn-helix DNA-binding domain (pfam01381) of the family of proteins related to the transcriptional regulator Rgg, also called RopB. Rgg is required for secretion of several proteins, including a cysteine proteinase associated with virulence. GadR is a positive regulator of a glutamate-dependent acid resistance mechanism. MutR is a transcriptional activator for mutacin biosynthesis genes in Streptococcus mutans. This family appears restricted to the low-GC Gram-positive bacteria, including at least eight members in Lactococcus lactis. [Regulatory functions, DNA interactions]


:

Pssm-ID: 273772  Cd Length: 220  Bit Score: 205.20  E-value: 9.85e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499298471   63 FIYRDFSSTEDDSFWIDFVELSGKNDVVGMQALLDKITLERTEQSEVRKAILHTRIQTINHylrtnvfdESNISDEYKKI 142
Cdd:TIGR01716   1 YILNNYKESEKESFGEKIVEAFYSNDIVGLKSLLSKISETKETYNRLNKAVIKARLHTLDH--------SYILSEEEVEF 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499298471  143 IHDYLWKMQTWTLEEVRIFSNGISFFEEEVQIHFYQIMLKSYEKYRYYDRGRLLFCHLFANLTDELIIQNKINYANLVLE 222
Cdd:TIGR01716  73 LTDYLFNIEEWTYYELYLFGNTMSILNSEDLEFLGKELLERLKRYRELNRYRRRVIQLLLNIAVLLIEKNEFSYAQYFLE 152

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 499298471  223 KLKEASETsgsFNSAFYRIVANYYQGAIWMKEGEVEKGYRQAKRAIQTWKELHYEAIADLYSVVLKQFLEK 293
Cdd:TIGR01716 153 KLEKILDP---EDDLYERILFNFLKGIILYKEGQKESGEEKIEQAIEIFDELGYPTLAAYYQKLLEKFVKK 220
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 5-61 1.16e-08

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


:

Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 50.63  E-value: 1.16e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 499298471   5 GELIREIRLSKGLTQKEVYTGI-ISRSYAIGFEKGKHEITLSLFEEILKRIMVPLDEF 61
Cdd:cd00093    1 GERLKELRKEKGLTQEELAEKLgVSRSTISRIENGKRNPSLETLEKLAKALGVSLDEL 58
 
Name Accession Description Interval E-value
RGG_Cterm TIGR01716
transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; This model describes the ...
 63-293 9.85e-66

transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; This model describes the whole, except for a 60 residue N-terminal helix-turn-helix DNA-binding domain (pfam01381) of the family of proteins related to the transcriptional regulator Rgg, also called RopB. Rgg is required for secretion of several proteins, including a cysteine proteinase associated with virulence. GadR is a positive regulator of a glutamate-dependent acid resistance mechanism. MutR is a transcriptional activator for mutacin biosynthesis genes in Streptococcus mutans. This family appears restricted to the low-GC Gram-positive bacteria, including at least eight members in Lactococcus lactis. [Regulatory functions, DNA interactions]


Pssm-ID: 273772  Cd Length: 220  Bit Score: 205.20  E-value: 9.85e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499298471   63 FIYRDFSSTEDDSFWIDFVELSGKNDVVGMQALLDKITLERTEQSEVRKAILHTRIQTINHylrtnvfdESNISDEYKKI 142
Cdd:TIGR01716   1 YILNNYKESEKESFGEKIVEAFYSNDIVGLKSLLSKISETKETYNRLNKAVIKARLHTLDH--------SYILSEEEVEF 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499298471  143 IHDYLWKMQTWTLEEVRIFSNGISFFEEEVQIHFYQIMLKSYEKYRYYDRGRLLFCHLFANLTDELIIQNKINYANLVLE 222
Cdd:TIGR01716  73 LTDYLFNIEEWTYYELYLFGNTMSILNSEDLEFLGKELLERLKRYRELNRYRRRVIQLLLNIAVLLIEKNEFSYAQYFLE 152

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 499298471  223 KLKEASETsgsFNSAFYRIVANYYQGAIWMKEGEVEKGYRQAKRAIQTWKELHYEAIADLYSVVLKQFLEK 293
Cdd:TIGR01716 153 KLEKILDP---EDDLYERILFNFLKGIILYKEGQKESGEEKIEQAIEIFDELGYPTLAAYYQKLLEKFVKK 220
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 5-61 1.16e-08

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 50.63  E-value: 1.16e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 499298471   5 GELIREIRLSKGLTQKEVYTGI-ISRSYAIGFEKGKHEITLSLFEEILKRIMVPLDEF 61
Cdd:cd00093    1 GERLKELRKEKGLTQEELAEKLgVSRSTISRIENGKRNPSLETLEKLAKALGVSLDEL 58
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
5-62 2.96e-08

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 50.00  E-value: 2.96e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 499298471   5 GELIREIRLSKGLTQKEV--YTGiISRSYAIGFEKGKHEITLSLFEEILKRIMVPLDEFF 62
Cdd:COG1396    9 GERLRELRKARGLTQEELaeRLG-VSRSTISRIERGRRNPSLETLLKLAKALGVSLDELL 67
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
8-61 1.06e-06

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 44.82  E-value: 1.06e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 499298471     8 IREIRLSKGLTQKEVYTGI-ISRSYAIGFEKGKHEITLSLFEEILKRIMVPLDEF 61
Cdd:smart00530   2 LKELREEKGLTQEELAEKLgVSRSTLSRIENGKRKPSLETLKKLAKALGVSLDEL 56
HTH_3 pfam01381
Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and ...
 8-61 9.71e-06

Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteriztic of the whole family.


Pssm-ID: 460181 [Multi-domain]  Cd Length: 55  Bit Score: 42.14  E-value: 9.71e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 499298471    8 IREIRLSKGLTQKEVYTGI-ISRSYAIGFEKGKHEITLSLFEEILKRIMVPLDEF 61
Cdd:pfam01381   1 LKELREELGLSQEELAEKLgVSRSTISKIENGKREPSLETLKKLAEALGVSLDEL 55
 
Name Accession Description Interval E-value
RGG_Cterm TIGR01716
transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; This model describes the ...
 63-293 9.85e-66

transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; This model describes the whole, except for a 60 residue N-terminal helix-turn-helix DNA-binding domain (pfam01381) of the family of proteins related to the transcriptional regulator Rgg, also called RopB. Rgg is required for secretion of several proteins, including a cysteine proteinase associated with virulence. GadR is a positive regulator of a glutamate-dependent acid resistance mechanism. MutR is a transcriptional activator for mutacin biosynthesis genes in Streptococcus mutans. This family appears restricted to the low-GC Gram-positive bacteria, including at least eight members in Lactococcus lactis. [Regulatory functions, DNA interactions]


Pssm-ID: 273772  Cd Length: 220  Bit Score: 205.20  E-value: 9.85e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499298471   63 FIYRDFSSTEDDSFWIDFVELSGKNDVVGMQALLDKITLERTEQSEVRKAILHTRIQTINHylrtnvfdESNISDEYKKI 142
Cdd:TIGR01716   1 YILNNYKESEKESFGEKIVEAFYSNDIVGLKSLLSKISETKETYNRLNKAVIKARLHTLDH--------SYILSEEEVEF 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499298471  143 IHDYLWKMQTWTLEEVRIFSNGISFFEEEVQIHFYQIMLKSYEKYRYYDRGRLLFCHLFANLTDELIIQNKINYANLVLE 222
Cdd:TIGR01716  73 LTDYLFNIEEWTYYELYLFGNTMSILNSEDLEFLGKELLERLKRYRELNRYRRRVIQLLLNIAVLLIEKNEFSYAQYFLE 152

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 499298471  223 KLKEASETsgsFNSAFYRIVANYYQGAIWMKEGEVEKGYRQAKRAIQTWKELHYEAIADLYSVVLKQFLEK 293
Cdd:TIGR01716 153 KLEKILDP---EDDLYERILFNFLKGIILYKEGQKESGEEKIEQAIEIFDELGYPTLAAYYQKLLEKFVKK 220
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 5-61 1.16e-08

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 50.63  E-value: 1.16e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 499298471   5 GELIREIRLSKGLTQKEVYTGI-ISRSYAIGFEKGKHEITLSLFEEILKRIMVPLDEF 61
Cdd:cd00093    1 GERLKELRKEKGLTQEELAEKLgVSRSTISRIENGKRNPSLETLEKLAKALGVSLDEL 58
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
5-62 2.96e-08

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 50.00  E-value: 2.96e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 499298471   5 GELIREIRLSKGLTQKEV--YTGiISRSYAIGFEKGKHEITLSLFEEILKRIMVPLDEFF 62
Cdd:COG1396    9 GERLRELRKARGLTQEELaeRLG-VSRSTISRIERGRRNPSLETLLKLAKALGVSLDELL 67
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
8-61 1.06e-06

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 44.82  E-value: 1.06e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 499298471     8 IREIRLSKGLTQKEVYTGI-ISRSYAIGFEKGKHEITLSLFEEILKRIMVPLDEF 61
Cdd:smart00530   2 LKELREEKGLTQEELAEKLgVSRSTLSRIENGKRKPSLETLKKLAKALGVSLDEL 56
XRE COG1476
DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];
5-63 1.83e-06

DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];


Pssm-ID: 441085 [Multi-domain]  Cd Length: 68  Bit Score: 44.84  E-value: 1.83e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 499298471   5 GELIREIRLSKGLTQKEVYTGI-ISRSYAIGFEKGKHEITLSLFEEILKRIMVPLDEFFF 63
Cdd:COG1476    6 GNRLKELRKERGLTQEELAELLgVSRQTISAIENGKYNPSLELALKIARALGVSLEELFS 65
HTH_3 pfam01381
Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and ...
 8-61 9.71e-06

Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteriztic of the whole family.


Pssm-ID: 460181 [Multi-domain]  Cd Length: 55  Bit Score: 42.14  E-value: 9.71e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 499298471    8 IREIRLSKGLTQKEVYTGI-ISRSYAIGFEKGKHEITLSLFEEILKRIMVPLDEF 61
Cdd:pfam01381   1 LKELREELGLSQEELAEKLgVSRSTISKIENGKREPSLETLKKLAEALGVSLDEL 55
aMBF1 COG1813
Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and ...
 4-60 4.58e-05

Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and HTH domains [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441418 [Multi-domain]  Cd Length: 70  Bit Score: 40.69  E-value: 4.58e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 499298471   4 YGELIREIRLSKGLTQKEVYTGI-ISRSYAIGFEKGKHEITLSLFEEILKRIMVPLDE 60
Cdd:COG1813   13 YGERIREAREARGLSQEELAEKLgVSESTIRRIERGEATPSLDTLRKLEKALGISLAE 70
AF2118 COG3620
Predicted transcriptional regulator, contains an XRE-type HTH domain (archaeal members contain ...
 5-54 4.95e-05

Predicted transcriptional regulator, contains an XRE-type HTH domain (archaeal members contain CBS pair) [Transcription];


Pssm-ID: 442838 [Multi-domain]  Cd Length: 95  Bit Score: 41.54  E-value: 4.95e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 499298471   5 GELIREIRLSKGLTQKEV--YTGiISRSYAIGFEKGKHEITLSLFEEILKRI 54
Cdd:COG3620   19 GEALRLMRKELGLSQLPVaeLVG-VSQSDILRIESGKRDPTVSTLEKIAEAL 69
HTH_19 pfam12844
Helix-turn-helix domain; Members of this family contains a DNA-binding helix-turn-helix domain. ...
 5-62 1.95e-03

Helix-turn-helix domain; Members of this family contains a DNA-binding helix-turn-helix domain. This family contains many example antitoxins from bacterial toxin-antitoxin systems. These antitoxins are likely to be DNA-binding domains.


Pssm-ID: 463728 [Multi-domain]  Cd Length: 64  Bit Score: 36.11  E-value: 1.95e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 499298471    5 GELIREIRLSKGLTQKEV-YTGIISRSYAIGFEKGKHEITLSLFEEILKRIMVPLDEFF 62
Cdd:pfam12844   1 GERLRKAREERGLTQEELaERLGISRSQLSAIENGKSVPPAETLYKIAELLGVPANWLL 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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