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Conserved domains on  [gi|499306066|ref|WP_010996841|]
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MULTISPECIES: type II toxin-antitoxin system Phd/YefM family antitoxin [Nostocaceae]

Protein Classification

type II toxin-antitoxin system Phd/YefM family antitoxin( domain architecture ID 10008295)

type II toxin-antitoxin (TA) system Phd/YefM family antitoxin similar to Mycobacterium tuberculosis VapB antitoxins, which are the antitoxin components of TA modules; VapB toxins bind to and neutralize the effect of their cognate VapC toxins

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Phd COG4118
Antitoxin component of toxin-antitoxin stability system, DNA-binding transcriptional repressor ...
 1-67 1.96e-05

Antitoxin component of toxin-antitoxin stability system, DNA-binding transcriptional repressor [Defense mechanisms];


:

Pssm-ID: 443294 [Multi-domain]  Cd Length: 65  Bit Score: 38.38  E-value: 1.96e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 499306066  1 MEHIATSELPETLQQIFAEIQRTKTpVTVTHDGEPLVIIYPATPQPQRPAFGAMKgsGEILGDVIAP 67
Cdd:COG4118   1 MKTVTVREAKAHLSELLDRVEAGEE-VVITRRGKPVARLVPVEPPRRPRALGLLK--GRLSDDFDEP 64
 
Name Accession Description Interval E-value
Phd COG4118
Antitoxin component of toxin-antitoxin stability system, DNA-binding transcriptional repressor ...
 1-67 1.96e-05

Antitoxin component of toxin-antitoxin stability system, DNA-binding transcriptional repressor [Defense mechanisms];


Pssm-ID: 443294 [Multi-domain]  Cd Length: 65  Bit Score: 38.38  E-value: 1.96e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 499306066  1 MEHIATSELPETLQQIFAEIQRTKTpVTVTHDGEPLVIIYPATPQPQRPAFGAMKgsGEILGDVIAP 67
Cdd:COG4118   1 MKTVTVREAKAHLSELLDRVEAGEE-VVITRRGKPVARLVPVEPPRRPRALGLLK--GRLSDDFDEP 64
PhdYeFM_antitox pfam02604
Antitoxin Phd_YefM, type II toxin-antitoxin system; Members of this family act as antitoxins ...
 1-42 7.69e-03

Antitoxin Phd_YefM, type II toxin-antitoxin system; Members of this family act as antitoxins in type II toxin-antitoxin systems. When bound to their toxin partners, they can bind DNA via the N-terminus and repress the expression of operons containing genes encoding the toxin and the antitoxin. This domain complexes with Txe toxins containing pfam06769, Fic/DOC toxins containing pfam02661 and YafO toxins containing pfam13957.


Pssm-ID: 460615  Cd Length: 67  Bit Score: 31.46  E-value: 7.69e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 499306066   1 MEHIATSELPETLQQIFAEIQRTKTPVTVTHDGEPLVIIYPA 42
Cdd:pfam02604  1 MKIVSISEARNNLSELLDEVEDGGEPVIITRRGKPVAVLLSL 42
 
Name Accession Description Interval E-value
Phd COG4118
Antitoxin component of toxin-antitoxin stability system, DNA-binding transcriptional repressor ...
 1-67 1.96e-05

Antitoxin component of toxin-antitoxin stability system, DNA-binding transcriptional repressor [Defense mechanisms];


Pssm-ID: 443294 [Multi-domain]  Cd Length: 65  Bit Score: 38.38  E-value: 1.96e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 499306066  1 MEHIATSELPETLQQIFAEIQRTKTpVTVTHDGEPLVIIYPATPQPQRPAFGAMKgsGEILGDVIAP 67
Cdd:COG4118   1 MKTVTVREAKAHLSELLDRVEAGEE-VVITRRGKPVARLVPVEPPRRPRALGLLK--GRLSDDFDEP 64
PhdYeFM_antitox pfam02604
Antitoxin Phd_YefM, type II toxin-antitoxin system; Members of this family act as antitoxins ...
 1-42 7.69e-03

Antitoxin Phd_YefM, type II toxin-antitoxin system; Members of this family act as antitoxins in type II toxin-antitoxin systems. When bound to their toxin partners, they can bind DNA via the N-terminus and repress the expression of operons containing genes encoding the toxin and the antitoxin. This domain complexes with Txe toxins containing pfam06769, Fic/DOC toxins containing pfam02661 and YafO toxins containing pfam13957.


Pssm-ID: 460615  Cd Length: 67  Bit Score: 31.46  E-value: 7.69e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 499306066   1 MEHIATSELPETLQQIFAEIQRTKTPVTVTHDGEPLVIIYPA 42
Cdd:pfam02604  1 MKIVSISEARNNLSELLDEVEDGGEPVIITRRGKPVAVLLSL 42
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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