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Conserved domains on  [gi|499313554|ref|WP_011004329|]
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AdeC/AdeK/OprM family multidrug efflux complex outer membrane factor [Ralstonia pseudosolanacearum]

Protein Classification

AdeC/AdeK/OprM family multidrug efflux complex outer membrane factor( domain architecture ID 11493206)

AdeC/AdeK/OprM family multidrug efflux complex outer membrane factor similar to Pseudomonas aeruginosa outer membrane protein OprM, a component of the MexAB-OprM efflux system that confers multidrug resistance

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
outer_NodT TIGR01845
efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Members of this ...
18-473 5.47e-143

efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Members of this model comprise a subfamily of the Outer Membrane Factor (TCDB 1.B.17) porins. OMF proteins operate in conjunction with a primary transporter of the RND, MFS, ABC, or PET systems, and a MFP (membrane fusion protein) to tranport substrates across membranes. The complex thus formed allows transport (export) of various solutes (heavy metal cations; drugs, oligosaccharides, proteins, etc.) across the two envelopes of the Gram-negative bacterial cell envelope in a single energy-coupled step. Current data suggest that the OMF (and not the MFP) is largely responsible for the formation of both the trans-outer membrane and trans-periplasmic channels. The roles played by the MFP have yet to be determined. [Cellular processes, Detoxification, Transport and binding proteins, Porins]


:

Pssm-ID: 273830 [Multi-domain]  Cd Length: 460  Bit Score: 417.97  E-value: 5.47e-143
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499313554   18 PDFHRPAAPAVAGYTPtppaptaSAPVEGGQvQRLVEGQEVAGQWWTMFGSGALNALVEAALKANPDLQSAEAALRVAQE 97
Cdd:TIGR01845  14 PDYARPETPLAAGYLE-------SDPTFGGQ-GRLSAGVWPAVDWWTAFGDPQLNALIEEALADNPDLQVAEARLRAARA 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499313554   98 NLAAARGSFFPSVDAQMASTRQKTAAvLASPLASGNLLYSLHTAQLTVSYAPDVFGGVRREVEASAAQAEVAAFQREAAY 177
Cdd:TIGR01845  86 NLRAARADFFPSLGLSASATRQKSSE-DASGTTSGGSLSNTSTLTLDVSYELDLFGKVRRAVESALAQLEAAEADSQAAR 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499313554  178 LTLTANVVAAAIQEASLRAQVQATHEAVAVASRLLAAVRKQRQLGQLGAADVAAQESALAQIEATLPPLEKQLALQRDLI 257
Cdd:TIGR01845 165 LTLSASIANAYVQLAALRAQLDVYHAALASRRKTLELTQKRYAAGVAAASDVRQAEAAVASAEAELPSLDVQIAQARNAL 244
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499313554  258 TVLAGRFPSETITQTFELESLQLPQALPLSLPSRLVEQRPDIRAAEAQLHAASAHIGVATAARLPSITLSADLGSSALAF 337
Cdd:TIGR01845 245 AALLGKGPSRGLAIARPLLLDQLPPDLPLSLPSDLLRRRPDIRAAERRLAAANAQIGVAKAAFFPSITLSASIGLSASQL 324
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499313554  338 SKLFTGGTGFWGLTGGIAQPIFRGGTLLHQQRAAEAAYDQAAAQCRSTVLTAFQSVADTLHAIDADARALQAASHAADAA 417
Cdd:TIGR01845 325 SRLFDGGSRFWSIGPALALPIFDGGSLRAALDSAKATYDAAVAQYRQTVLTAFQEVADALVALQALARRLDAQRQAVEQA 404
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 499313554  418 RKSLTIAQRQWTLGLIAYPAVLQAEQAYQQSLVSLAQARAGRLADSVALLQALGGG 473
Cdd:TIGR01845 405 QEALSLAQTRYRAGLDSYLTVLEAQRSLLTAQRSLATLQARRLSDSVALYKALGGG 460
 
Name Accession Description Interval E-value
outer_NodT TIGR01845
efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Members of this ...
18-473 5.47e-143

efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Members of this model comprise a subfamily of the Outer Membrane Factor (TCDB 1.B.17) porins. OMF proteins operate in conjunction with a primary transporter of the RND, MFS, ABC, or PET systems, and a MFP (membrane fusion protein) to tranport substrates across membranes. The complex thus formed allows transport (export) of various solutes (heavy metal cations; drugs, oligosaccharides, proteins, etc.) across the two envelopes of the Gram-negative bacterial cell envelope in a single energy-coupled step. Current data suggest that the OMF (and not the MFP) is largely responsible for the formation of both the trans-outer membrane and trans-periplasmic channels. The roles played by the MFP have yet to be determined. [Cellular processes, Detoxification, Transport and binding proteins, Porins]


Pssm-ID: 273830 [Multi-domain]  Cd Length: 460  Bit Score: 417.97  E-value: 5.47e-143
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499313554   18 PDFHRPAAPAVAGYTPtppaptaSAPVEGGQvQRLVEGQEVAGQWWTMFGSGALNALVEAALKANPDLQSAEAALRVAQE 97
Cdd:TIGR01845  14 PDYARPETPLAAGYLE-------SDPTFGGQ-GRLSAGVWPAVDWWTAFGDPQLNALIEEALADNPDLQVAEARLRAARA 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499313554   98 NLAAARGSFFPSVDAQMASTRQKTAAvLASPLASGNLLYSLHTAQLTVSYAPDVFGGVRREVEASAAQAEVAAFQREAAY 177
Cdd:TIGR01845  86 NLRAARADFFPSLGLSASATRQKSSE-DASGTTSGGSLSNTSTLTLDVSYELDLFGKVRRAVESALAQLEAAEADSQAAR 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499313554  178 LTLTANVVAAAIQEASLRAQVQATHEAVAVASRLLAAVRKQRQLGQLGAADVAAQESALAQIEATLPPLEKQLALQRDLI 257
Cdd:TIGR01845 165 LTLSASIANAYVQLAALRAQLDVYHAALASRRKTLELTQKRYAAGVAAASDVRQAEAAVASAEAELPSLDVQIAQARNAL 244
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499313554  258 TVLAGRFPSETITQTFELESLQLPQALPLSLPSRLVEQRPDIRAAEAQLHAASAHIGVATAARLPSITLSADLGSSALAF 337
Cdd:TIGR01845 245 AALLGKGPSRGLAIARPLLLDQLPPDLPLSLPSDLLRRRPDIRAAERRLAAANAQIGVAKAAFFPSITLSASIGLSASQL 324
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499313554  338 SKLFTGGTGFWGLTGGIAQPIFRGGTLLHQQRAAEAAYDQAAAQCRSTVLTAFQSVADTLHAIDADARALQAASHAADAA 417
Cdd:TIGR01845 325 SRLFDGGSRFWSIGPALALPIFDGGSLRAALDSAKATYDAAVAQYRQTVLTAFQEVADALVALQALARRLDAQRQAVEQA 404
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 499313554  418 RKSLTIAQRQWTLGLIAYPAVLQAEQAYQQSLVSLAQARAGRLADSVALLQALGGG 473
Cdd:TIGR01845 405 QEALSLAQTRYRAGLDSYLTVLEAQRSLLTAQRSLATLQARRLSDSVALYKALGGG 460
TolC COG1538
Outer membrane protein TolC [Cell wall/membrane/envelope biogenesis];
71-475 1.87e-52

Outer membrane protein TolC [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441147 [Multi-domain]  Cd Length: 367  Bit Score: 181.39  E-value: 1.87e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499313554  71 LNALVEAALKANPDLQSAEAALRVAQENLAAARGSFFPSvdaqmastrqktaavlasplasgnllyslhtaqltvsYAPD 150
Cdd:COG1538    2 LDELIERALANNPDLRAARARVEAARAQLRQARAGLLPS-------------------------------------QELD 44
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499313554 151 VFGGVRREVEASAAQAEVAAFQREAAYLTLTANVVAAAIQEASLRAQVQATHEAVAVASRLLAAVRKQRQLGQLGAADVA 230
Cdd:COG1538   45 LGGKRRARIEAAKAQAEAAEADLRAARLDLAAEVAQAYFDLLAAQEQLALAEENLALAEELLELARARYEAGLASRLDVL 124
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499313554 231 AQESALAQIEATLPPLEKQLALQRDLITVLAGRFPSETITQTFELESLQLPQALPLSLPSRLVEQRPDIRAAEAQLHAAS 310
Cdd:COG1538  125 QAEAQLAQARAQLAQAEAQLAQARNALALLLGLPPPAPLDLPDPLPPLPPLPPSLPGLPSEALERRPDLRAAEAQLEAAE 204
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499313554 311 AHIGVATAARLPSITLSADLGSSalAFSKLFTGGTGFWGLTGGIAQPIFRGGTLLHQQRAAEAAYDQAAAQCRSTVLTAF 390
Cdd:COG1538  205 AEIGVARAAFLPSLSLSASYGYS--SSDDLFSGGSDTWSVGLSLSLPLFDGGRNRARVRAAKAQLEQAEAQYEQTVLQAL 282
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499313554 391 QSVADTLHAIDADARALQAASHAADAARKSLTIAQRQWTLGLIAYPAVLQAEQAYQQSLVSLAQARAGRLADSVALLQAL 470
Cdd:COG1538  283 QEVEDALAALRAAREQLEALEEALEAAEEALELARARYRAGLASLLDVLDAQRELLQAQLNLIQARYDYLLALVQLYRAL 362

                 ....*
gi 499313554 471 GGGWW 475
Cdd:COG1538  363 GGGWE 367
PRK09837 PRK09837
Cu(I)/Ag(I) efflux RND transporter outer membrane protein;
18-474 4.58e-36

Cu(I)/Ag(I) efflux RND transporter outer membrane protein;


Pssm-ID: 182103 [Multi-domain]  Cd Length: 461  Bit Score: 139.24  E-value: 4.58e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499313554  18 PDFHRPAAPAVAGYTPTPPAPTASApveggqvqrlvEGQEVAGqWWTMFGSGALNALVEAALKANPDLQSAEAALRVAQE 97
Cdd:PRK09837  23 PDYQRPAMPVPQQFSLSQNGLVNAA-----------DNYQNTG-WRTFFVDNQVKTLISEALVNNRDLRMATLKVQEARA 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499313554  98 NLAAARGSFFPSVDAQMASTrqktaavLASPLASGNLLYSLHTAQLTVSYAPDVFGGVRREVEASAAQAEVAAFQREAAY 177
Cdd:PRK09837  91 QYRLTDADRYPQLNGEGSGS-------WSGNLKGDTATTREYSTGLNLSFDLDFFGRLKNMSEAERQNYLASEEAQRAVH 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499313554 178 LTLTANVVAAAIQEASLRAQVQATHEAVAVASRLLAAVRKQRQLGqlgAADVAAQESALAQIEATLPPLEK---QLALQR 254
Cdd:PRK09837 164 ILLVSNVAQSYFNQQLAYAQLQIAEETLRNYQQSYAFVEKQLLTG---SSNVLALEQARGVIESTRADIAKrqgELAQAN 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499313554 255 DLITVLAGRFPSETITQTFELESLQlPQALPLSLPSRLVEQRPDIRAAEAQLHAASAHIGVATAARLPSITLSADLGSSA 334
Cdd:PRK09837 241 NALQLLLGSYGKLPQAQTVNSDSLQ-SVKLPAGLSSQILLQRPDIMEAEHALMAANANIGAARAAFFPSISLTSGLSTSS 319
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499313554 335 LAFSKLFTGGTGFWGLTGGIAQPIFRGGTLLHQQRAAEAAYDQAAAQCRSTVLTAFQSVADTLHAIDADARALQAASHAA 414
Cdd:PRK09837 320 SDLSSLFNASSGMWNFIPKIEIPIFNAGRNQANLDLAEIRQQQSVVNYEQKIQNAFKEVADALALRQSLNDQISAQQRYL 399
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 499313554 415 DAARKSLTIAQRQWTLGLIAYPAVLQAEQAY---QQSLVSLAQARAgrlADSVALLQALGGGW 474
Cdd:PRK09837 400 ASLQITLQRARALYQHGAVSYLEVLDAERSLfatRQTLLDLNYARQ---VNEISLFTALGGGW 459
OEP pfam02321
Outer membrane efflux protein; The OEP family (Outer membrane efflux protein) form trimeric ...
290-471 1.10e-15

Outer membrane efflux protein; The OEP family (Outer membrane efflux protein) form trimeric channels that allow export of a variety of substrates in Gram negative bacteria. Each member of this family is composed of two repeats. The trimeric channel is composed of a 12 stranded all beta sheet barrel that spans the outer membrane, and a long all helical barrel that spans the periplasm.


Pssm-ID: 396757 [Multi-domain]  Cd Length: 181  Bit Score: 74.87  E-value: 1.10e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499313554  290 SRLVEQRPDIRAAEAQLHAASAHIGVATAARLPSITLSADLGSSAlAFSKLFTGGTGFWGLTGGIAQPIFRGGTLLHQQR 369
Cdd:pfam02321   1 ALALENNPDLKAAEAEIEAAEANIKLAKSEFLPDLSLSGGYGYNS-NNSESGGDDPGTGEVGLGLSQPLFDGGKRRARVK 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499313554  370 AAEAAYDQAAAQCRSTVLTAFQSVADTLHAIDADARALQAASHAADAARKSLTIAQRQWTLGLIAYPAVLQAEQAYQQSL 449
Cdd:pfam02321  80 AAKAQVEAAEAQLEQARQQLRLEVAQAYLQLLAAKEQLELAEQALELAEEALELAEARYEAGLISLLDVLQAEVELLEAR 159
                         170       180
                  ....*....|....*....|..
gi 499313554  450 VSLAQARAGRLADSVALLQALG 471
Cdd:pfam02321 160 LELLNAEADLELALAQLEQLLG 181
 
Name Accession Description Interval E-value
outer_NodT TIGR01845
efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Members of this ...
18-473 5.47e-143

efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Members of this model comprise a subfamily of the Outer Membrane Factor (TCDB 1.B.17) porins. OMF proteins operate in conjunction with a primary transporter of the RND, MFS, ABC, or PET systems, and a MFP (membrane fusion protein) to tranport substrates across membranes. The complex thus formed allows transport (export) of various solutes (heavy metal cations; drugs, oligosaccharides, proteins, etc.) across the two envelopes of the Gram-negative bacterial cell envelope in a single energy-coupled step. Current data suggest that the OMF (and not the MFP) is largely responsible for the formation of both the trans-outer membrane and trans-periplasmic channels. The roles played by the MFP have yet to be determined. [Cellular processes, Detoxification, Transport and binding proteins, Porins]


Pssm-ID: 273830 [Multi-domain]  Cd Length: 460  Bit Score: 417.97  E-value: 5.47e-143
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499313554   18 PDFHRPAAPAVAGYTPtppaptaSAPVEGGQvQRLVEGQEVAGQWWTMFGSGALNALVEAALKANPDLQSAEAALRVAQE 97
Cdd:TIGR01845  14 PDYARPETPLAAGYLE-------SDPTFGGQ-GRLSAGVWPAVDWWTAFGDPQLNALIEEALADNPDLQVAEARLRAARA 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499313554   98 NLAAARGSFFPSVDAQMASTRQKTAAvLASPLASGNLLYSLHTAQLTVSYAPDVFGGVRREVEASAAQAEVAAFQREAAY 177
Cdd:TIGR01845  86 NLRAARADFFPSLGLSASATRQKSSE-DASGTTSGGSLSNTSTLTLDVSYELDLFGKVRRAVESALAQLEAAEADSQAAR 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499313554  178 LTLTANVVAAAIQEASLRAQVQATHEAVAVASRLLAAVRKQRQLGQLGAADVAAQESALAQIEATLPPLEKQLALQRDLI 257
Cdd:TIGR01845 165 LTLSASIANAYVQLAALRAQLDVYHAALASRRKTLELTQKRYAAGVAAASDVRQAEAAVASAEAELPSLDVQIAQARNAL 244
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499313554  258 TVLAGRFPSETITQTFELESLQLPQALPLSLPSRLVEQRPDIRAAEAQLHAASAHIGVATAARLPSITLSADLGSSALAF 337
Cdd:TIGR01845 245 AALLGKGPSRGLAIARPLLLDQLPPDLPLSLPSDLLRRRPDIRAAERRLAAANAQIGVAKAAFFPSITLSASIGLSASQL 324
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499313554  338 SKLFTGGTGFWGLTGGIAQPIFRGGTLLHQQRAAEAAYDQAAAQCRSTVLTAFQSVADTLHAIDADARALQAASHAADAA 417
Cdd:TIGR01845 325 SRLFDGGSRFWSIGPALALPIFDGGSLRAALDSAKATYDAAVAQYRQTVLTAFQEVADALVALQALARRLDAQRQAVEQA 404
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 499313554  418 RKSLTIAQRQWTLGLIAYPAVLQAEQAYQQSLVSLAQARAGRLADSVALLQALGGG 473
Cdd:TIGR01845 405 QEALSLAQTRYRAGLDSYLTVLEAQRSLLTAQRSLATLQARRLSDSVALYKALGGG 460
TolC COG1538
Outer membrane protein TolC [Cell wall/membrane/envelope biogenesis];
71-475 1.87e-52

Outer membrane protein TolC [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441147 [Multi-domain]  Cd Length: 367  Bit Score: 181.39  E-value: 1.87e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499313554  71 LNALVEAALKANPDLQSAEAALRVAQENLAAARGSFFPSvdaqmastrqktaavlasplasgnllyslhtaqltvsYAPD 150
Cdd:COG1538    2 LDELIERALANNPDLRAARARVEAARAQLRQARAGLLPS-------------------------------------QELD 44
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499313554 151 VFGGVRREVEASAAQAEVAAFQREAAYLTLTANVVAAAIQEASLRAQVQATHEAVAVASRLLAAVRKQRQLGQLGAADVA 230
Cdd:COG1538   45 LGGKRRARIEAAKAQAEAAEADLRAARLDLAAEVAQAYFDLLAAQEQLALAEENLALAEELLELARARYEAGLASRLDVL 124
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499313554 231 AQESALAQIEATLPPLEKQLALQRDLITVLAGRFPSETITQTFELESLQLPQALPLSLPSRLVEQRPDIRAAEAQLHAAS 310
Cdd:COG1538  125 QAEAQLAQARAQLAQAEAQLAQARNALALLLGLPPPAPLDLPDPLPPLPPLPPSLPGLPSEALERRPDLRAAEAQLEAAE 204
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499313554 311 AHIGVATAARLPSITLSADLGSSalAFSKLFTGGTGFWGLTGGIAQPIFRGGTLLHQQRAAEAAYDQAAAQCRSTVLTAF 390
Cdd:COG1538  205 AEIGVARAAFLPSLSLSASYGYS--SSDDLFSGGSDTWSVGLSLSLPLFDGGRNRARVRAAKAQLEQAEAQYEQTVLQAL 282
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499313554 391 QSVADTLHAIDADARALQAASHAADAARKSLTIAQRQWTLGLIAYPAVLQAEQAYQQSLVSLAQARAGRLADSVALLQAL 470
Cdd:COG1538  283 QEVEDALAALRAAREQLEALEEALEAAEEALELARARYRAGLASLLDVLDAQRELLQAQLNLIQARYDYLLALVQLYRAL 362

                 ....*
gi 499313554 471 GGGWW 475
Cdd:COG1538  363 GGGWE 367
PRK09837 PRK09837
Cu(I)/Ag(I) efflux RND transporter outer membrane protein;
18-474 4.58e-36

Cu(I)/Ag(I) efflux RND transporter outer membrane protein;


Pssm-ID: 182103 [Multi-domain]  Cd Length: 461  Bit Score: 139.24  E-value: 4.58e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499313554  18 PDFHRPAAPAVAGYTPTPPAPTASApveggqvqrlvEGQEVAGqWWTMFGSGALNALVEAALKANPDLQSAEAALRVAQE 97
Cdd:PRK09837  23 PDYQRPAMPVPQQFSLSQNGLVNAA-----------DNYQNTG-WRTFFVDNQVKTLISEALVNNRDLRMATLKVQEARA 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499313554  98 NLAAARGSFFPSVDAQMASTrqktaavLASPLASGNLLYSLHTAQLTVSYAPDVFGGVRREVEASAAQAEVAAFQREAAY 177
Cdd:PRK09837  91 QYRLTDADRYPQLNGEGSGS-------WSGNLKGDTATTREYSTGLNLSFDLDFFGRLKNMSEAERQNYLASEEAQRAVH 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499313554 178 LTLTANVVAAAIQEASLRAQVQATHEAVAVASRLLAAVRKQRQLGqlgAADVAAQESALAQIEATLPPLEK---QLALQR 254
Cdd:PRK09837 164 ILLVSNVAQSYFNQQLAYAQLQIAEETLRNYQQSYAFVEKQLLTG---SSNVLALEQARGVIESTRADIAKrqgELAQAN 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499313554 255 DLITVLAGRFPSETITQTFELESLQlPQALPLSLPSRLVEQRPDIRAAEAQLHAASAHIGVATAARLPSITLSADLGSSA 334
Cdd:PRK09837 241 NALQLLLGSYGKLPQAQTVNSDSLQ-SVKLPAGLSSQILLQRPDIMEAEHALMAANANIGAARAAFFPSISLTSGLSTSS 319
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499313554 335 LAFSKLFTGGTGFWGLTGGIAQPIFRGGTLLHQQRAAEAAYDQAAAQCRSTVLTAFQSVADTLHAIDADARALQAASHAA 414
Cdd:PRK09837 320 SDLSSLFNASSGMWNFIPKIEIPIFNAGRNQANLDLAEIRQQQSVVNYEQKIQNAFKEVADALALRQSLNDQISAQQRYL 399
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 499313554 415 DAARKSLTIAQRQWTLGLIAYPAVLQAEQAY---QQSLVSLAQARAgrlADSVALLQALGGGW 474
Cdd:PRK09837 400 ASLQITLQRARALYQHGAVSYLEVLDAERSLfatRQTLLDLNYARQ---VNEISLFTALGGGW 459
type_I_sec_TolC TIGR01844
type I secretion outer membrane protein, TolC family; Members of this model are outer membrane ...
71-471 2.04e-18

type I secretion outer membrane protein, TolC family; Members of this model are outer membrane proteins from the TolC subfamily within the RND (Resistance-Nodulation-cell Division) efflux systems. These proteins, unlike the NodT subfamily, appear not to be lipoproteins. All are believed to participate in type I protein secretion, an ABC transporter system for protein secretion without cleavage of a signal sequence, although they may, like TolC, participate also in the efflux of smaller molecules as well. This family includes the well-documented examples TolC (E. coli), PrtF (Erwinia), and AprF (Pseudomonas aeruginosa). [Protein fate, Protein and peptide secretion and trafficking, Transport and binding proteins, Porins]


Pssm-ID: 273829 [Multi-domain]  Cd Length: 415  Bit Score: 87.04  E-value: 2.04e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499313554   71 LNALVEAALKANPDLQSAEAALRVAQENLAAARGSFFPSVDAQMASTRQKTAAvlaSPLASGNLLYSLHTAQLTVSYAPD 150
Cdd:TIGR01844   5 LLDAVLLALANNPELRAARAQRDAGEEQVAQARAALLPQLGLTANYGYSNTYP---TESRGRNTDLNSGSSTLTLSQPLF 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499313554  151 VFGGVRREVEASAAQAEVAAFQREAAYLTLTANVVAAAIQEASLRAQVQATHEAVAVASRLLAAVRKQRQLGQLGAADVA 230
Cdd:TIGR01844  82 DGGSTWNAVRAAEAAALAARETLRATAQDLILRTAEAYMEVLRAQEILALAEANLAALKEQLDLARARFDVGLGTRTDVL 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499313554  231 AQESALAQIEATLPPLEKQLALQRDLITVLAGRFPSETitqtfeLESLQLPQALPLSLPSRL---VEQRPDIRAAEAQLH 307
Cdd:TIGR01844 162 QAEARYASARAQLIQAQNNLDDAKAQLRRLVGQPELAP------LAVPSFPAELPEPLDQLLeiaEASNPLLLAAQAAVD 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499313554  308 AASAHIGVATAARLPSITLSADLGSSAlafsklfTGGTGFWGLTGGIAQ-------PIFRGGTLLHQQRAAEAAYDQAAA 380
Cdd:TIGR01844 236 AARYQVEQARAGHLPTLSLTASTGNSD-------TSSGGSGNSDSDTYSvglnvsiPLYQGGATSAQVRQAAHQLNQSRS 308
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499313554  381 QCRSTVLTAFQSVADTLHAIDADARALQAASHAADAARKSLTIAQRQWTLGLIAYPAVLQAEQAYQQSLVSLAQARAGRL 460
Cdd:TIGR01844 309 TLESQKRTVRQQVRNAWSNLNAAAASVQAYEQQVASAQKALDAYRQEYQVGTRTLLDVLNAEQELYQARQELANARYDYL 388
                         410
                  ....*....|.
gi 499313554  461 ADSVALLQALG 471
Cdd:TIGR01844 389 QAQLNLLSATG 399
PRK11459 PRK11459
multidrug resistance outer membrane protein MdtQ; Provisional
61-474 2.88e-18

multidrug resistance outer membrane protein MdtQ; Provisional


Pssm-ID: 183143 [Multi-domain]  Cd Length: 478  Bit Score: 87.31  E-value: 2.88e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499313554  61 QWWTMFGSGALNALVEAALKANPDLQSAEAALRVAQENLAAARGSFFPSVDAQMASTRQKTAAV-LASPLASGNLL---- 135
Cdd:PRK11459  57 QWWKAYHDNQLDSLINNALQNAPDMQVAEQRIQLAEAQAKAVAAQDGPQLDFSADMERQKMSAEgLMGPFALNDPAagtt 136
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499313554 136 ---YSLHTAQLTVSYAPDVFGGVRREVEASAAQAEVAAFQREAayltlTANVVAAAIQEASLRAQVQATHEAV--AVASR 210
Cdd:PRK11459 137 gpwYTNGTFGLTAGWDLDLWGKNRAEVTARIGTVKARAAEREQ-----TRQLLAGSVARLYWEWQTQAALNTVlqQIEKE 211
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499313554 211 LLAAVRKQRQLGQLGAAdvAAQESALAQIEATlpPLEKQLALQRDLITVLAGRFPSETITQT--FELESLQLPQA---LP 285
Cdd:PRK11459 212 QNNIIATDRQLYQNGIT--SSVEGVETDINAS--KTRQQLNDVAGKMKIIEARLSALTNTQTksLKLKPVALPKVasqLP 287
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499313554 286 LSLPSRLVEQRPDIRAAEAQLHAASAHIGVATAARLPSITLSADLGSSALAFSKLFTGGTGFWGLTGGIAQPIFRGGTLL 365
Cdd:PRK11459 288 DELGYSLLARRADLQAAHWYIESSLSTIDAAKAAFYPDINLMAFLQQDALHLSDLFRHSAQQMGVTAGLTLPIFDSGRLN 367
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499313554 366 HQQRAAEAAYDQAAAQCRSTVLTAFQSVADTLHAIDADARALQAASHAADAARKSLTIAQRQWTLGLIAYPAVLQAEQAY 445
Cdd:PRK11459 368 ANLDIAKAQSNLSIASYNKAVVDAVNDVARAASQVETLAEKNQHQQQIERDALRVVGLAQARFNAGIIAGSRVSEAKIPA 447
                        410       420
                 ....*....|....*....|....*....
gi 499313554 446 QQSLVSLAQARAGRLADSVALLQALGGGW 474
Cdd:PRK11459 448 LRERANGLLLQGQWLDASIQLTSALGGGY 476
PRK09915 PRK09915
MdtP family multidrug efflux transporter outer membrane subunit;
59-474 1.74e-16

MdtP family multidrug efflux transporter outer membrane subunit;


Pssm-ID: 182142 [Multi-domain]  Cd Length: 488  Bit Score: 81.85  E-value: 1.74e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499313554  59 AGQWWTMFGSGALNALVEAALKANPDLQSAEAALRVAQENLAAARGSFFPSVDAQMASTRQKTAAVLASPLASGNL---- 134
Cdd:PRK09915  57 QAQWWKQLNDPQLDALIQRTLSGSHTLAEAKLREEKAQSQADLLDAGSQLQVAALGMLNRQRVSANGFLSPYAMDApalg 136
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499313554 135 ----LYSLHTAQLTVSYAPDVFGGVRREVEASAAQAEVAAFQREAAYLTLTANVvaaaiqeASLRAQVQATHEAVAVASR 210
Cdd:PRK09915 137 mdgpYYTEATVGLFAGLDLDLWGVHRSAVAAAIGAHNAALAETAAVELSLTTGV-------AQLYYSMQASYQMLDLLEQ 209
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499313554 211 LLAAVRKQRQLGQLGAA----DVAAQESALAQIEATlpplEKQLALQRDLITVLagrfpSETITQTFELESLQLPQALPL 286
Cdd:PRK09915 210 TRDVIDYAVKAHQSKVAhgleAQVPFHGARAQILAV----DKQIAAVKGQITET-----RESLRALIGAGASDMPEIKPV 280
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499313554 287 SLPS-----------RLVEQRPDIRAAEAQLHAASAHIGVATAARLPSITLSADLGSSALAFSKLFTGGTGFWGLTGGIA 355
Cdd:PRK09915 281 ALPRvqtgipatlsyELLARRPDLQAMRWYVQASLDQVDSARALFYPSFDIKAFFGLDAIHLDTLFKKTSRQFNFIPGLK 360
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499313554 356 QPIFRGGTLLHQQRAAEAAYDQAAAQCRSTVLTAFQSVADT---LHAIDaDARALQaaSHAADAARKSLTIAQRQWTLGL 432
Cdd:PRK09915 361 LPLFDGGRLNANLEGTRAASNMMIERYNQSVLNAVRDVAVNgtrLQTLN-DEREMQ--AERVEATRFTQRAAEAAYQRGL 437
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|..
gi 499313554 433 IAYPAVLQAEQAYQQSLVSLAQARAGRLADSVALLQALGGGW 474
Cdd:PRK09915 438 TSRLQATEARLPVLAEEMSLLMLDSRRVIQSIQLMKSLGGGY 479
OEP pfam02321
Outer membrane efflux protein; The OEP family (Outer membrane efflux protein) form trimeric ...
290-471 1.10e-15

Outer membrane efflux protein; The OEP family (Outer membrane efflux protein) form trimeric channels that allow export of a variety of substrates in Gram negative bacteria. Each member of this family is composed of two repeats. The trimeric channel is composed of a 12 stranded all beta sheet barrel that spans the outer membrane, and a long all helical barrel that spans the periplasm.


Pssm-ID: 396757 [Multi-domain]  Cd Length: 181  Bit Score: 74.87  E-value: 1.10e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499313554  290 SRLVEQRPDIRAAEAQLHAASAHIGVATAARLPSITLSADLGSSAlAFSKLFTGGTGFWGLTGGIAQPIFRGGTLLHQQR 369
Cdd:pfam02321   1 ALALENNPDLKAAEAEIEAAEANIKLAKSEFLPDLSLSGGYGYNS-NNSESGGDDPGTGEVGLGLSQPLFDGGKRRARVK 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499313554  370 AAEAAYDQAAAQCRSTVLTAFQSVADTLHAIDADARALQAASHAADAARKSLTIAQRQWTLGLIAYPAVLQAEQAYQQSL 449
Cdd:pfam02321  80 AAKAQVEAAEAQLEQARQQLRLEVAQAYLQLLAAKEQLELAEQALELAEEALELAEARYEAGLISLLDVLQAEVELLEAR 159
                         170       180
                  ....*....|....*....|..
gi 499313554  450 VSLAQARAGRLADSVALLQALG 471
Cdd:pfam02321 160 LELLNAEADLELALAQLEQLLG 181
OEP pfam02321
Outer membrane efflux protein; The OEP family (Outer membrane efflux protein) form trimeric ...
76-254 1.52e-10

Outer membrane efflux protein; The OEP family (Outer membrane efflux protein) form trimeric channels that allow export of a variety of substrates in Gram negative bacteria. Each member of this family is composed of two repeats. The trimeric channel is composed of a 12 stranded all beta sheet barrel that spans the outer membrane, and a long all helical barrel that spans the periplasm.


Pssm-ID: 396757 [Multi-domain]  Cd Length: 181  Bit Score: 60.23  E-value: 1.52e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499313554   76 EAALKANPDLQSAEAALRVAQENLAAARGSFFPSVDAQMASTRQktaavlASPLASGNLLYSLHTAQLTVSYAPDVFGGV 155
Cdd:pfam02321   1 ALALENNPDLKAAEAEIEAAEANIKLAKSEFLPDLSLSGGYGYN------SNNSESGGDDPGTGEVGLGLSQPLFDGGKR 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499313554  156 RREVEASAAQAEVAAFQREAAYLTLTANVVAAAIQEASLRAQVQATHEAVAVASRLLAAVRKQRQLGQLGAADVAAQESA 235
Cdd:pfam02321  75 RARVKAAKAQVEAAEAQLEQARQQLRLEVAQAYLQLLAAKEQLELAEQALELAEEALELAEARYEAGLISLLDVLQAEVE 154
                         170
                  ....*....|....*....
gi 499313554  236 LAQIEATLPPLEKQLALQR 254
Cdd:pfam02321 155 LLEARLELLNAEADLELAL 173
TolC COG1538
Outer membrane protein TolC [Cell wall/membrane/envelope biogenesis];
70-243 5.15e-09

Outer membrane protein TolC [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441147 [Multi-domain]  Cd Length: 367  Bit Score: 57.74  E-value: 5.15e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499313554  70 ALNALVEAALKANPDLQSAEAALRVAQENLAAARGSFFPSVDAQMASTRQKTAAVLASPLASGnllyslhTAQLTVSYAP 149
Cdd:COG1538  178 SLPGLPSEALERRPDLRAAEAQLEAAEAEIGVARAAFLPSLSLSASYGYSSSDDLFSGGSDTW-------SVGLSLSLPL 250
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499313554 150 DVFGGVRREVEASAAQAEVAAFQREAAYLTLTANVVAAAIQEASLRAQVQATHEAVAVASRLLAAVRKQRQLGQLGAADV 229
Cdd:COG1538  251 FDGGRNRARVRAAKAQLEQAEAQYEQTVLQALQEVEDALAALRAAREQLEALEEALEAAEEALELARARYRAGLASLLDV 330
                        170
                 ....*....|....
gi 499313554 230 AAQESALAQIEATL 243
Cdd:COG1538  331 LDAQRELLQAQLNL 344
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
37-306 1.32e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 41.46  E-value: 1.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499313554  37 APTASAPVEGGQVQRLVEGQEVAGQWWTMFGSGALNALVEAALKAN--PDLQSAEAALRVAQENlAAARGSFFPSVDAQM 114
Cdd:COG1196  506 FLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAALAAALQNIvvEDDEVAAAAIEYLKAA-KAGRATFLPLDKIRA 584
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499313554 115 ASTRQKTAAVLASPLASGNLLYSLHTAQLTVSYAPDVFGGVRREVEASAAQAEVAAFQREAAY-LTLTANVVAAAIQEAS 193
Cdd:COG1196  585 RAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLReVTLEGEGGSAGGSLTG 664
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499313554 194 LRAQVQATHEAVAVASRLLAAVRKQRQLGQLGAADVAAQESALAQIEATLPPLEKQLALQRDLITVLAGRFPSETITQTF 273
Cdd:COG1196  665 GSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEE 744
                        250       260       270
                 ....*....|....*....|....*....|...
gi 499313554 274 ELESLQLPQALPLSLPSRLVEQRpDIRAAEAQL 306
Cdd:COG1196  745 EELLEEEALEELPEPPDLEELER-ELERLEREI 776
PksD COG3321
Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites ...
171-485 3.72e-03

Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442550 [Multi-domain]  Cd Length: 1386  Bit Score: 40.24  E-value: 3.72e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499313554  171 FQREAAYLTLTANVVAAA-IQEASLRAQVQATHEAVAVASRLLAAVRKQRQLGQLGAADVAAQESALAQIEATLPPLEKQ 249
Cdd:COG3321   868 FQREDAAAALLAAALAAAlAAAAALGALLLAALAAALAAALLALAAAAAAALALAAAALAALLALVALAAAAAALLALAA 947
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499313554  250 LALQRDLITVLAGRFPSETITQTFELESLQLPQALPLSLPSRLVEQRPDIRAAEAQLHAASAHIGVATAARLPSITLSAD 329
Cdd:COG3321   948 AAAAAAAALAAAEAGALLLLAAAAAAAAAAAAAAAAAAAAAAAAAAAALAAAAALALLAAAALLLAAAAAAAALLALAAL 1027
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499313554  330 LGSSALAFSKLFTGGTGFWGLTGGIAQPIFRGGTLLHQQRAAEAAYDQAAAQCRSTVLTAFQSVADTLHAIDADARALQA 409
Cdd:COG3321  1028 LAAAAAALAAAAAAAAAAAALAALAAAAAAAAALALALAALLLLAALAELALAAAALALAAALAAAALALALAALAAALL 1107
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 499313554  410 ASHAADAARKSLTIAQRQWTLGLIAYPAVLQAEQAYQQSLVSLAQARAGRLADSVALLQALGGGWWNRAPAGARQD 485
Cdd:COG3321  1108 LLALLAALALAAAAAALLALAALLAAAAAAAALAAAAAAAAALALAAAAAALAAALAAALLAAAALLLALALALAA 1183
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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