|
Name |
Accession |
Description |
Interval |
E-value |
| Thr-synth_1 |
cd01563 |
Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last ... |
43-361 |
3.67e-158 |
|
Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants, OPH is an intermediate between the methionine and threonine/isoleucine pathways. Thus threonine synthase competes for OPH with cystathionine-gamma-synthase, the first enzyme in the methionine pathway. These enzymes are in general dimers. Members of this CD, Thr-synth_1, are widely distributed in bacteria, archaea and higher plants.
Pssm-ID: 107206 [Multi-domain] Cd Length: 324 Bit Score: 447.43 E-value: 3.67e-158
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 43 WERFSEFFPLELDPELSLGEGDTPLTRAKKLSKELG-IELYLKNETINPTWSFKDRGTYLGIHRAIQLDFRRIGTVSTGN 121
Cdd:cd01563 1 LWRYRELLPVTEDDIVSLGEGNTPLVRAPRLGERLGgKNLYVKDEGLNPTGSFKDRGMTVAVSKAKELGVKAVACASTGN 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 122 MAASVAAYGAHSELEVYILVSSTIPEEKIKALAPYGAKIVKVHGDYGELYYRALEIGQKKGIYFINSDDPFRVEGYKSIS 201
Cdd:cd01563 81 TSASLAAYAARAGIKCVVFLPAGKALGKLAQALAYGATVLAVEGNFDDALRLVRELAEENWIYLSNSLNPYRLEGQKTIA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 202 FEISEEI---TPDYVIVPTSSGGLFRGIVKGFLEAKNSGLIEKLPRFFVVQAEGCSPICKAFNAGKEKIERFENPHTIAH 278
Cdd:cd01563 161 FEIAEQLgweVPDYVVVPVGNGGNITAIWKGFKELKELGLIDRLPRMVGVQAEGAAPIVRAFKEGKDDIEPVENPETIAT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 279 AIENPYPPSGNAVLRLLKKLNGICTTVTDEEILEAQKILGR-EGIFVQLASATGIAAVKKLRRKGIIKEGAIVVSILTGS 357
Cdd:cd01563 241 AIRIGNPASGPKALRAVRESGGTAVAVSDEEILEAQKLLARtEGIFVEPASAASLAGLKKLREEGIIDKGERVVVVLTGH 320
|
....
gi 499321828 358 GLKT 361
Cdd:cd01563 321 GLKD 324
|
|
| ThrC |
COG0498 |
Threonine synthase [Amino acid transport and metabolism]; Threonine synthase is part of the ... |
1-383 |
1.10e-138 |
|
Threonine synthase [Amino acid transport and metabolism]; Threonine synthase is part of the Pathway/BioSystem: Threonine biosynthesis
Pssm-ID: 440264 [Multi-domain] Cd Length: 394 Bit Score: 400.34 E-value: 1.10e-138
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 1 MLRCTSCGRMYSFDSPYQRCECGEPLElELFNGMYKK---KGKRVWeRFSEFFPL-ELDPELSLGEGDTPLTRAKKLSKE 76
Cdd:COG0498 1 KLRCTRCGATFSDALLYLCPDCGGLLP-DSYPALSREdlaSRRGLW-RYRELLPFdDEEKAVSLGEGGTPLVKAPRLADE 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 77 LGIELYLKNETINPTWSFKDRGTYLGIHRAIQLDFRRIGTVSTGNMAASVAAYGAHSELEVYILV-SSTIPEEKIKALAP 155
Cdd:COG0498 79 LGKNLYVKEEGHNPTGSFKDRAMQVAVSLALERGAKTIVCASSGNGSAALAAYAARAGIEVFVFVpEGKVSPGQLAQMLT 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 156 YGAKIVKVHGDYGELYYRALEIGQKKGIYFINSDDPFRVEGYKSISFEISEEIT--PDYVIVPTSSGGLFRGIVKGFLEA 233
Cdd:COG0498 159 YGAHVIAVDGNFDDAQRLVKELAADEGLYAVNSINPARLEGQKTYAFEIAEQLGrvPDWVVVPTGNGGNILAGYKAFKEL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 234 KNSGLIEKLPRFFVVQAEGCSPICKAFNAGKEKIERfENPHTIAHAIENPYPPSGNAVLRLLKKLNGICTTVTDEEILEA 313
Cdd:COG0498 239 KELGLIDRLPRLIAVQATGCNPILTAFETGRDEYEP-ERPETIAPSMDIGNPSNGERALFALRESGGTAVAVSDEEILEA 317
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 499321828 314 QKILGR-EGIFVQLASATGIAAVKKLRRKGIIKEGAIVVSILTGSGLKTLRYI-----KQPKVEECSLQRLEECIG 383
Cdd:COG0498 318 IRLLARrEGIFVEPATAVAVAGLRKLREEGEIDPDEPVVVLSTGHGLKFPDAVrealgGEPLAVPPDLEAVKAAVE 393
|
|
| PRK08197 |
PRK08197 |
threonine synthase; Validated |
2-360 |
6.43e-91 |
|
threonine synthase; Validated
Pssm-ID: 181283 [Multi-domain] Cd Length: 394 Bit Score: 278.81 E-value: 6.43e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 2 LRCTSCGRMYSFDSPYQRCECGEPLELEL-FNGMYKKKGKR--------VWeRFSEFFPLeLDPE--LSLGEGDTPLTRA 70
Cdd:PRK08197 8 LECSKCGETYDADQVHNLCKCGKPLLVRYdLEAVKQAVTREalagrpanLW-RYHELLPV-RDPEhiVSLGEGMTPLLPL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 71 KKLSKELGI-ELYLKNETINPTWSFKDRGTYLGIHRAIQLDFRRIGTVSTGNMAASVAAYGAHSELEVYILVSSTIPEEK 149
Cdd:PRK08197 86 PRLGKALGIgRLWVKDEGLNPTGSFKARGLAVGVSRAKELGVKHLAMPTNGNAGAAWAAYAARAGIRATIFMPADAPEIT 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 150 IKALAPYGAKIVKVHG---DYGELyyrALEIGQKKGIYFINS-DDPFRVEGYKSISFEISEEI---TPDYVIVPTSSG-G 221
Cdd:PRK08197 166 RLECALAGAELYLVDGlisDAGKI---VAEAVAEYGWFDVSTlKEPYRIEGKKTMGLELAEQLgwrLPDVILYPTGGGvG 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 222 LFrGIVKGFLEAKNSGLI-EKLPRFFVVQAEGCSPICKAFNAGKEKIERFENPHTIAHAIENPYPPSGNAVLRLLKKLNG 300
Cdd:PRK08197 243 LI-GIWKAFDELEALGWIgGKRPRLVAVQAEGCAPIVKAWEEGKEESEFWEDAHTVAFGIRVPKALGDFLVLDAVRETGG 321
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 499321828 301 ICTTVTDEEILEAQKILGR-EGIFVQLASATGIAAVKKLRRKGIIKEGAIVVSILTGSGLK 360
Cdd:PRK08197 322 CAIAVSDDAILAAQRELAReEGLFACPEGAATFAAARQLRESGWLKGDERVVLFNTGSGLK 382
|
|
| PALP |
pfam00291 |
Pyridoxal-phosphate dependent enzyme; Members of this family are all pyridoxal-phosphate ... |
58-356 |
1.57e-85 |
|
Pyridoxal-phosphate dependent enzyme; Members of this family are all pyridoxal-phosphate dependent enzymes. This family includes: serine dehydratase EC:4.2.1.13 P20132, threonine dehydratase EC:4.2.1.16, tryptophan synthase beta chain EC:4.2.1.20, threonine synthase EC:4.2.99.2, cysteine synthase EC:4.2.99.8 P11096, cystathionine beta-synthase EC:4.2.1.22, 1-aminocyclopropane-1-carboxylate deaminase EC:4.1.99.4.
Pssm-ID: 459749 [Multi-domain] Cd Length: 295 Bit Score: 261.48 E-value: 1.57e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 58 LSLGEGDTPLTRAKKLSKELGIELYLKNETINPTWSFKDRGTYLGIHRAIQ-LDFRRIGTVSTGNMAASVAAYGAHSELE 136
Cdd:pfam00291 1 ISLGIGPTPLVRLPRLSKELGVDVYLKLESLNPTGSFKDRGALNLLLRLKEgEGGKTVVEASSGNHGRALAAAAARLGLK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 137 VYILVSSTIPEEKIKALAPYGAKIVKVHGDYGELYYRALEIGQK-KGIYFINS-DDPFRVEGYKSISFEISEEI--TPDY 212
Cdd:pfam00291 81 VTIVVPEDAPPGKLLLMRALGAEVVLVGGDYDEAVAAARELAAEgPGAYYINQyDNPLNIEGYGTIGLEILEQLggDPDA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 213 VIVPTSSGGLFRGIVKGFLEAKNSglieklPRFFVVQAEGCSPICKAFNAGkeKIERFENPHTIAHAIENPYPPsGNAVL 292
Cdd:pfam00291 161 VVVPVGGGGLIAGIARGLKELGPD------VRVIGVEPEGAPALARSLAAG--RPVPVPVADTIADGLGVGDEP-GALAL 231
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 499321828 293 RLLKKLNGICTTVTDEEILEAQKILGR-EGIFVQLASATGIAAVkKLRRKGIIKEGAIVVSILTG 356
Cdd:pfam00291 232 DLLDEYVGEVVTVSDEEALEAMRLLARrEGIVVEPSSAAALAAL-KLALAGELKGGDRVVVVLTG 295
|
|
| thrC |
TIGR00260 |
threonine synthase; Involved in threonine biosynthesis it catalyses the reaction ... |
42-361 |
1.69e-77 |
|
threonine synthase; Involved in threonine biosynthesis it catalyses the reaction O-PHOSPHO-L-HOMOSERINE + H(2)O = L-THREONINE + ORTHOPHOSPHATE using pyridoxal phosphate as a cofactor. the enzyme is distantly related to the serine/threonine dehydratases which are also pyridoxal-phosphate dependent enzymes. the pyridoxal-phosphate binding site is a Lys (K) residues present at residue 70 of the model. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 272986 [Multi-domain] Cd Length: 327 Bit Score: 241.90 E-value: 1.69e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 42 VWeRFSEFFPLELDPELSLGEGDTPLTRAKKLSKELGI-ELYLKNETINPTWSFKDRGTYLGIHRAIQLDFRRIGTVSTG 120
Cdd:TIGR00260 1 VW-RYREFLPVTEKDLVDLGEGVTPLFRAPALAANVGIkNLYVKELGHNPTLSFKDRGMAVALTKALELGNDTVLCASTG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 121 NMAASVAAYGAHSELEVYILV-SSTIPEEKIKALAPYGAKIVKVHGDYGELYYRALEIGQKKGIYFINS--DDPFRVEGY 197
Cdd:TIGR00260 80 NTGAAAAAYAGKAGLKVVVLYpAGKISLGKLAQALGYNAEVVAIDGNFDDAQRLVKQLFEDKPALGLNSanSIPYRLEGQ 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 198 KSISFEISEEI---TPDYVIVPTSSGGLFRGIVKGFLEAKNSGLIEkLPRFFVVQAEGCSPICKAFNAGKEKIERfENPH 274
Cdd:TIGR00260 160 KTYAFEAVEQLgweAPDKVVVPVPNSGNFGAIWKGFKEKKMLGLDS-LPVKRGIQAEGAADIVRAFLEGGQWEPI-ETPE 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 275 TIAHAIENPYPPSGNAVLRLLKKLNGICTTVTDEEILEAQKILGR-EGIFVQLASATGIAAVKKLRRKGIIKEGAIVVSI 353
Cdd:TIGR00260 238 TLSTAMDIGNPANWPRALEAFRRSNGYAEDLSDEEILEAIKLLAReEGYFVEPHSAVAVAALLKLVEKGTADPAERVVCA 317
|
....*...
gi 499321828 354 LTGSGLKT 361
Cdd:TIGR00260 318 LTGNGLKD 325
|
|
| PRK05638 |
PRK05638 |
threonine synthase; Validated |
1-361 |
1.56e-71 |
|
threonine synthase; Validated
Pssm-ID: 235539 [Multi-domain] Cd Length: 442 Bit Score: 230.47 E-value: 1.56e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 1 MLRCTSCGRMYSFDSPYqRCECGEPLEL-----ELFNGMYKKKGKRVWeRFSEFFPlELDPELSLGEGDTPLTRAKkLSK 75
Cdd:PRK05638 1 KMKCPKCGREYNSYIPP-FCICGELLEIiydysSVDVRKWKNRDPGVW-RYKELLP-QVKKIISLGEGGTPLIRAR-ISE 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 76 ELGIELYLKNETINPTWSFKDRGTYLGIHRAIQLDFRRIGTVSTGNMAASVAAYGAHSELEVYILVSSTIPEEKIKALAP 155
Cdd:PRK05638 77 KLGENVYIKDETRNPTGSFRDRLATVAVSYGLPYAANGFIVASDGNAAASVAAYSARAGKEAFVVVPRKVDKGKLIQMIA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 156 YGAKIVKVHGDYGELYYRALEIGQKKGIYFINSDDP-FRVEGYKSISFEISEEITPDYVIVPTSSGGLFRGIVKGFLEAK 234
Cdd:PRK05638 157 FGAKIIRYGESVDEAIEYAEELARLNGLYNVTPEYNiIGLEGQKTIAFELWEEINPTHVIVPTGSGSYLYSIYKGFKELL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 235 NSGLIEKLPRFFVVQAEGCSPICKAFNAGKEKIErfenpHTIAHAIENPYPPSGNAVLRLLKKLNGICTTVTDEEILEAQ 314
Cdd:PRK05638 237 EIGVIEEIPKLIAVQTERCNPIASEILGNKTKCN-----ETKALGLYVKNPVMKEYVSEAIKESGGTAVVVNEEEIMAGE 311
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 499321828 315 KILGREGIFVQLASATGIAAVKKLRRKGIIKEGAIVVSILTGSGLKT 361
Cdd:PRK05638 312 KLLAKEGIFAELSSAVVMPALLKLGEEGYIEKGDKVVLVVTGSGLKG 358
|
|
| PRK08329 |
PRK08329 |
threonine synthase; Validated |
1-362 |
1.03e-69 |
|
threonine synthase; Validated
Pssm-ID: 236244 [Multi-domain] Cd Length: 347 Bit Score: 222.78 E-value: 1.03e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 1 MLRCTSCGRMYSFDSPYqRCECGEPLELEL-FNGMYKKKGKRVWERFSEFFPL--ELDPELSLGEgdTPLTrakklskEL 77
Cdd:PRK08329 1 MLRCTKCGRTYEEKFKL-RCDCGGTLLVEReYGSFDSPREYLDMRRYIDYLPVdeEFLPHLTPPI--TPTV-------KR 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 78 GIELYLKNETINPTWSFKDRGTYLGIHRAIQLDFRRIGTVSTGNMAASVAAYGAHSELEVYILVSSTIPEEKIKALAPYG 157
Cdd:PRK08329 71 SIKVYFKLDYLQPTGSFKDRGTYVTVAKLKEEGINEVVIDSSGNAALSLALYSLSEGIKVHVFVSYNASKEKISLLSRLG 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 158 AKIVKVHGDYGELYYRALEIGQKKGIYFINS-DDPFRVEGYKSISFEISEEI-TPDYVIVPTSSGGLFRGIVKGFLEAKN 235
Cdd:PRK08329 151 AELHFVEGDRMEVHEEAVKFSKRNNIPYVSHwLNPYFLEGTKTIAYEIYEQIgVPDYAFVPVGSGTLFLGIWKGFKELHE 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 236 SGLIEKLPRFFVVQAEGCSPICKafnagkekieRFENPHTIAHAIENPYPPSGNAVLRLLKKLNGICTTVTDEEILEAQK 315
Cdd:PRK08329 231 MGEISKMPKLVAVQAEGYESLCK----------RSKSENKLADGIAIPEPPRKEEMLRALEESNGFCISVGEEETRAALH 300
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 499321828 316 ILGREGIFVQLASATGIAAVKKLRRKGIIKEGAIVVSILTGSGLKTL 362
Cdd:PRK08329 301 WLRRMGFLVEPTSAVALAAYWKLLEEGLIEGGSKVLLPLSGSGLKNL 347
|
|
| Trp-synth-beta_II |
cd00640 |
Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP) ... |
65-357 |
1.56e-62 |
|
Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan synthase beta chain (Trp-synth_B), cystathionine beta-synthase (CBS), O-acetylserine sulfhydrylase (CS), serine dehydratase (Ser-dehyd), threonine dehydratase (Thr-dehyd), diaminopropionate ammonia lyase (DAL), and threonine synthase (Thr-synth). ACCD catalyzes the conversion of 1-aminocyclopropane-1-carboxylate to alpha-ketobutyrate and ammonia. Tryptophan synthase folds into a tetramer, where the beta chain is the catalytic PLP-binding subunit and catalyzes the formation of L-tryptophan from indole and L-serine. CBS is a tetrameric hemeprotein that catalyzes condensation of serine and homocysteine to cystathionine. CS is a homodimer that catalyzes the formation of L-cysteine from O-acetyl-L-serine. Ser-dehyd catalyzes the conversion of L- or D-serine to pyruvate and ammonia. Thr-dehyd is active as a homodimer and catalyzes the conversion of L-threonine to 2-oxobutanoate and ammonia. DAL is also a homodimer and catalyzes the alpha, beta-elimination reaction of both L- and D-alpha, beta-diaminopropionate to form pyruvate and ammonia. Thr-synth catalyzes the formation of threonine and inorganic phosphate from O-phosphohomoserine.
Pssm-ID: 107202 [Multi-domain] Cd Length: 244 Bit Score: 200.82 E-value: 1.56e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 65 TPLTRAKKLSKELGIELYLKNETINPTWSFKDRGTYLGIHRAIQLDFRRIGTV---STGNMAASVAAYGAHSELEVYILV 141
Cdd:cd00640 1 TPLVRLKRLSKLGGANIYLKLEFLNPTGSFKDRGALNLILLAEEEGKLPKGVIiesTGGNTGIALAAAAARLGLKCTIVM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 142 SSTIPEEKIKALAPYGAKIVKVHGDYGELYYRALEIGQK-KGIYFINS-DDPFRVEGYKSISFEISE---EITPDYVIVP 216
Cdd:cd00640 81 PEGASPEKVAQMRALGAEVVLVPGDFDDAIALAKELAEEdPGAYYVNQfDNPANIAGQGTIGLEILEqlgGQKPDAVVVP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 217 TSSGGLFRGIVKGFLEAKnsglieKLPRFFVVQAEgcspickafnagkekierfenphtiahaienpyppsgnavlrllk 296
Cdd:cd00640 161 VGGGGNIAGIARALKELL------PNVKVIGVEPE--------------------------------------------- 189
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 499321828 297 klngiCTTVTDEEILEAQKILGR-EGIFVQLASATGIAAVKKLRRKGiiKEGAIVVSILTGS 357
Cdd:cd00640 190 -----VVTVSDEEALEAIRLLAReEGILVEPSSAAALAAALKLAKKL--GKGKTVVVILTGG 244
|
|
| PRK06450 |
PRK06450 |
threonine synthase; Validated |
3-362 |
6.29e-60 |
|
threonine synthase; Validated
Pssm-ID: 180565 [Multi-domain] Cd Length: 338 Bit Score: 196.88 E-value: 6.29e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 3 RCTSCGRMYSfdSPYQ-RCE-CGEPLELELFNGMYKkkgkrvwERFSEFFPLeLDPELSLGEGDTPLTRAKklskelgiE 80
Cdd:PRK06450 5 VCMKCGKERE--SIYEiRCKkCGGPFEILIDFEFDK-------NLERKNFPY-IKHFISLGEGRTPLIKKG--------N 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 81 LYLKNETINPTWSFKDRGTYLGIHRAIQLDFRRIGTVSTGNMAASVAAYGAHSELEVYILVSSTIPEEKIKALAPYGAKI 160
Cdd:PRK06450 67 IWFKLDFLNPTGSYKDRGSVTLISYLAEKGIKQISEDSSGNAGASIAAYGAAAGIEVKIFVPETASGGKLKQIESYGAEV 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 161 VKVHGDYGELYYRAleigQKKGIYFINS--DDPFRvEGYKSISFEISEEI---TPDYVIVPTSSGGLFRGIVKGFLEAKN 235
Cdd:PRK06450 147 VRVRGSREDVAKAA----ENSGYYYASHvlQPQFR-DGIRTLAYEIAKDLdwkIPNYVFIPVSAGTLLLGVYSGFKHLLD 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 236 SGLIEKLPRFFVVQAEGCSPICKAFNagKEKIERFENPHTIAHAIENPYPPSGNAVLRLLKKlNGICTTVTDEEILEAQK 315
Cdd:PRK06450 222 SGVISEMPKIVAVQTEQVSPLCAKFK--GISYTPPDKVTSIADALVSTRPFLLDYMVKALSE-YGECIVVSDNEIVEAWK 298
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 499321828 316 ILGREGIFVQLASATGIAAVKKLRrkgiiKEGAIVVsiLTGSGLKTL 362
Cdd:PRK06450 299 ELAKKGLLVEYSSATVYAAYKKYS-----VNDSVLV--LTGSGLKVL 338
|
|
| PLN02569 |
PLN02569 |
threonine synthase |
4-360 |
9.10e-55 |
|
threonine synthase
Pssm-ID: 178182 [Multi-domain] Cd Length: 484 Bit Score: 187.71 E-value: 9.10e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 4 CTSCGRMYSFDSPYQRCECGEPLE-------LELFNGMYKKK------GKRVWERFS------EFFPLELDPE--LSLGE 62
Cdd:PLN02569 52 CPLTGEKYSLDEVVYRSKSGGLLDvrhdmeaLKRYDGKYWRAlfdsrvGKTTWPYGSgvwskkEWVLPEIDDDdiVSLFE 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 63 GDTPLTRAKKLSKE-LGI-ELYLKNETINPTWSFKDRGTYLGIHRAIQLdfRR-------IGTVSTGNMAASVAAYGAHS 133
Cdd:PLN02569 132 GNSNLFWAERLGKEfLGMnDLWVKHCGISHTGSFKDLGMTVLVSQVNRL--RKmakpvvgVGCASTGDTSAALSAYCAAA 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 134 ELEVYI-LVSSTIPEEKIKALAPYGAKIVKVHGDYGELYYRALEIGQKKGIYFINSDDPFRVEGYKSISFEISEEI---T 209
Cdd:PLN02569 210 GIPSIVfLPADKISIAQLVQPIANGALVLSIDTDFDGCMRLIREVTAELPIYLANSLNSLRLEGQKTAAIEILQQFdweV 289
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 210 PDYVIVPTSSGGLFRGIVKGFLEAKNSGLIEKLPRFFVVQAEGCSPICKAFNAGKEKIERFENPHTIAHAIENPYPPSGN 289
Cdd:PLN02569 290 PDWVIVPGGNLGNIYAFYKGFKMCKELGLVDRLPRLVCAQAANANPLYRAYKSGWEEFKPVKANPTFASAIQIGDPVSID 369
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 499321828 290 AVLRLLKKLNGICTTVTDEEILEAQKILGREGIFVQLASATGIAAVKKLRRKGIIKEGAIVVSILTGSGLK 360
Cdd:PLN02569 370 RAVYALKESNGIVEEATEEELMDAQAEADKTGMFLCPHTGVALAALKKLRASGVIGPTDRTVVVSTAHGLK 440
|
|
| PRK06381 |
PRK06381 |
threonine synthase; Validated |
63-356 |
3.67e-45 |
|
threonine synthase; Validated
Pssm-ID: 235789 Cd Length: 319 Bit Score: 157.95 E-value: 3.67e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 63 GDTPLTRAKKLSKELGI-ELYLKNETINPTWSFKDRGTYLGIHRAIQLDFRRIGTVSTGNMAASVAAYGAHSELEVYILV 141
Cdd:PRK06381 14 GGTPLLRARKLEEELGLrKIYLKFEGANPTGTQKDRIAEAHVRRAMRLGYSGITVGTCGNYGASIAYFARLYGLKAVIFI 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 142 SSTIPEEKIKALAPYGAKIVKVHGDYGELYYRALEIGQKKGIYFIN--SDDP-FRVEGYKSISFEISEEI--TPDYVIVP 216
Cdd:PRK06381 94 PRSYSNSRVKEMEKYGAEIIYVDGKYEEAVERSRKFAKENGIYDANpgSVNSvVDIEAYSAIAYEIYEALgdVPDAVAVP 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 217 TSSGGLFRGIVKGFLEAKNSGLIEKLPRFFVVQAEGCSPICKAFNAGKEKIERFENPHTIAHAIENPYPPS----GNAVL 292
Cdd:PRK06381 174 VGNGTTLAGIYHGFRRLYDRGKTSRMPRMIGVSTSGGNQIVESFKRGSSEVVDLEVDEIRETAVNEPLVSYrsfdGDNAL 253
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 499321828 293 RLLKKLNGICTTVTDEEILEAQKILGR-EGIFVQLASATGIAAVKKLRRKGIIKEGaiVVSILTG 356
Cdd:PRK06381 254 EAIYDSHGYAFGFSDDEMVKYAELLRRmEGLNALPASASALAALVKYLKKNGVNDN--VVAVITG 316
|
|
| Thr-dehyd |
cd01562 |
Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. ... |
65-356 |
8.88e-37 |
|
Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly converted into NH4+. The direct deamination is catalyzed by threonine dehydratase, in which pyridoxal phosphate (PLP) is the prosthetic group. Threonine dehydratase is widely distributed in all three major phylogenetic divisions.
Pssm-ID: 107205 [Multi-domain] Cd Length: 304 Bit Score: 135.31 E-value: 8.88e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 65 TPLTRAKKLSKELGIELYLKNETINPTWSFKDRGTYlgiHRAIQL--DFRRIG--TVSTGNMAASVAAYGAHSELEVYIL 140
Cdd:cd01562 18 TPLLTSPTLSELLGAEVYLKCENLQKTGSFKIRGAY---NKLLSLseEERAKGvvAASAGNHAQGVAYAAKLLGIPATIV 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 141 VSSTIPEEKIKALAPYGAKIVKVHGDYGELYYRALEIGQKKGIYFIN-SDDPFRVEGYKSISFEISEEI-TPDYVIVPTS 218
Cdd:cd01562 95 MPETAPAAKVDATRAYGAEVVLYGEDFDEAEAKARELAEEEGLTFIHpFDDPDVIAGQGTIGLEILEQVpDLDAVFVPVG 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 219 SGGLFRGI---VKgfleAKNSGLieklpRFFVVQAEGCSPICKAFNAGkeKIERFENPHTIAHAIENPYPpsGNAVLRLL 295
Cdd:cd01562 175 GGGLIAGIataVK----ALSPNT-----KVIGVEPEGAPAMAQSLAAG--KPVTLPEVDTIADGLAVKRP--GELTFEII 241
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 499321828 296 KKLNGICTTVTDEEILEAQK-ILGREGIFVQLASATGIAAVKKLRRKgiiKEGAIVVSILTG 356
Cdd:cd01562 242 RKLVDDVVTVSEDEIAAAMLlLFEREKLVAEPAGALALAALLSGKLD---LKGKKVVVVLSG 300
|
|
| IlvA |
COG1171 |
Threonine deaminase [Amino acid transport and metabolism]; Threonine deaminase is part of the ... |
65-356 |
1.33e-36 |
|
Threonine deaminase [Amino acid transport and metabolism]; Threonine deaminase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis
Pssm-ID: 440784 [Multi-domain] Cd Length: 327 Bit Score: 135.16 E-value: 1.33e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 65 TPLTRAKKLSKELGIELYLKNETINPTWSFKDRGTYlgiHRAIQL--DFRRIG--TVSTGNMAASVAAYGAHSELEVYIL 140
Cdd:COG1171 25 TPLLRSPTLSERLGAEVYLKLENLQPTGSFKLRGAY---NALASLseEERARGvvAASAGNHAQGVAYAARLLGIPATIV 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 141 VSSTIPEEKIKALAPYGAKIVKVHGDYGELYYRALEIGQKKGIYFINS-DDPFRVEGYKSISFEISEEITP-DYVIVPTS 218
Cdd:COG1171 102 MPETAPAVKVAATRAYGAEVVLHGDTYDDAEAAAAELAEEEGATFVHPfDDPDVIAGQGTIALEILEQLPDlDAVFVPVG 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 219 SGGLFRGIVkGFLEAKNSGlieklPRFFVVQAEGCSPICKAFNAGkeKIERFENPHTIAHAIENPYPpsGNAVLRLLKKL 298
Cdd:COG1171 182 GGGLIAGVA-AALKALSPD-----IRVIGVEPEGAAAMYRSLAAG--EPVTLPGVDTIADGLAVGRP--GELTFEILRDL 251
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 499321828 299 NGICTTVTDEEILEAQKILG-REGIFVQLASATGIAAVKKLRRKGiikEGAIVVSILTG 356
Cdd:COG1171 252 VDDIVTVSEDEIAAAMRLLLeRTKIVVEPAGAAALAALLAGKERL---KGKRVVVVLSG 307
|
|
| CBS_like |
cd01561 |
CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS ... |
63-360 |
1.56e-22 |
|
CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine. Deficiency of CBS leads to homocystinuria, an inherited disease of sulfur metabolism characterized by increased levels of the toxic metabolite homocysteine. Cysteine synthase on the other hand catalyzes the last step of cysteine biosynthesis. This subgroup also includes an O-Phosphoserine sulfhydrylase found in hyperthermophilic archaea which produces L-cysteine from sulfide and the more thermostable O-phospho-L-serine.
Pssm-ID: 107204 [Multi-domain] Cd Length: 291 Bit Score: 96.04 E-value: 1.56e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 63 GDTPLTRAKKLSKELGIELYLKNETINPTWSFKDR-GTYLgIHRAIQLDFRRIGTV----STGNMAASVAAYGAHSELEV 137
Cdd:cd01561 1 GNTPLVRLNRLSPGTGAEIYAKLEFFNPGGSVKDRiALYM-IEDAEKRGLLKPGTTiiepTSGNTGIGLAMVAAAKGYRF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 138 YILVSSTIPEEKIKALAPYGAKIVKV----HGDYGELYYRALEIGQK-KGIYFIN-SDDPFRVEG-YKSISFEISEEI-- 208
Cdd:cd01561 80 IIVMPETMSEEKRKLLRALGAEVILTpeaeADGMKGAIAKARELAAEtPNAFWLNqFENPANPEAhYETTAPEIWEQLdg 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 209 TPDYVIVPTSSGGLFRGIVKgFLEAKNSGLieklpRFFVVQAEGcSPICKAFNAGKEKIErfenphtiahAIENPYPPSg 288
Cdd:cd01561 160 KVDAFVAGVGTGGTITGVAR-YLKEKNPNV-----RIVGVDPVG-SVLFSGGPPGPHKIE----------GIGAGFIPE- 221
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 499321828 289 naVLRLlKKLNGIcTTVTDEEILE-AQKILGREGIFVQLASATGIAAVKKLRRKgiIKEGAIVVSILTGSGLK 360
Cdd:cd01561 222 --NLDR-SLIDEV-VRVSDEEAFAmARRLAREEGLLVGGSSGAAVAAALKLAKR--LGPGKTIVTILPDSGER 288
|
|
| PRK08638 |
PRK08638 |
bifunctional threonine ammonia-lyase/L-serine ammonia-lyase TdcB; |
65-356 |
2.34e-22 |
|
bifunctional threonine ammonia-lyase/L-serine ammonia-lyase TdcB;
Pssm-ID: 236317 [Multi-domain] Cd Length: 333 Bit Score: 96.34 E-value: 2.34e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 65 TPLTRAKKLSKELGIELYLKNETINPTWSFKDRGTYLGIHRAIQLDFRR-IGTVSTGNMAASVAAYGAHSELEVYILVSS 143
Cdd:PRK08638 28 TPLPRSNYLSERCKGEIFLKLENMQRTGSFKIRGAFNKLSSLTDAEKRKgVVACSAGNHAQGVALSCALLGIDGKVVMPK 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 144 TIPEEKIKALAPYGAKIVkVHGD-YGELYYRALEIGQKKGIYFINS-DDPFRVEGYKSISFEISEEI-TPDYVIVPTSSG 220
Cdd:PRK08638 108 GAPKSKVAATCGYGAEVV-LHGDnFNDTIAKVEEIVEEEGRTFIPPyDDPKVIAGQGTIGLEILEDLwDVDTVIVPIGGG 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 221 GLFRGIVKGfLEAKNSGLieklpRFFVVQAEGCSPICKAFNAGkeKIERFENPHTIAHAIENPYPpsGNAVLRLLKKLNG 300
Cdd:PRK08638 187 GLIAGIAVA-LKSINPTI-----HIIGVQSENVHGMAASFYAG--EITTHRTTGTLADGCDVSRP--GNLTYEIVRELVD 256
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 499321828 301 ICTTVTDEEILEAQK-ILGREGIFVQLASATGIAAVKKLRRKGIIKeGAIVVSILTG 356
Cdd:PRK08638 257 DIVLVSEDEIRNAMKdLIQRNKVVTEGAGALATAALLSGKLDQYIQ-NKKVVAIISG 312
|
|
| CysK |
COG0031 |
Cysteine synthase [Amino acid transport and metabolism]; Cysteine synthase is part of the ... |
63-364 |
2.53e-22 |
|
Cysteine synthase [Amino acid transport and metabolism]; Cysteine synthase is part of the Pathway/BioSystem: Cysteine biosynthesis
Pssm-ID: 439802 [Multi-domain] Cd Length: 301 Bit Score: 95.89 E-value: 2.53e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 63 GDTPLTRAKKLSKELGIELYLKNETINPTWSFKDR-GTYLgIHRAIQldfR-RI---GTV---STGNMAASVAAYGAHSE 134
Cdd:COG0031 12 GNTPLVRLNRLSPGPGAEIYAKLESFNPGGSVKDRiALSM-IEDAEK---RgLLkpgGTIveaTSGNTGIGLAMVAAAKG 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 135 LEVYILVSSTIPEEKIKALAPYGAKIVKVHGDYGELYY--RALEIGQK-KGIYFIN-SDDPFRVEG-YKSISFEISE--E 207
Cdd:COG0031 88 YRLILVMPETMSKERRALLRAYGAEVVLTPGAEGMKGAidKAEELAAEtPGAFWPNqFENPANPEAhYETTGPEIWEqtD 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 208 ITPDYVIVPTSSGGLFRGIVKgFLEAKNSGLieklpRFFVVQAEGcSPICKAFNAGKEKIERfenphtiahaIENPYPPs 287
Cdd:COG0031 168 GKVDAFVAGVGTGGTITGVGR-YLKERNPDI-----KIVAVEPEG-SPLLSGGEPGPHKIEG----------IGAGFVP- 229
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 499321828 288 gnAVLRlLKKLNGICtTVTDEE-ILEAQKILGREGIFVQLASATGIAAVKKLRRKgiIKEGAIVVSILTGSGlktLRY 364
Cdd:COG0031 230 --KILD-PSLIDEVI-TVSDEEaFAMARRLAREEGILVGISSGAAVAAALRLAKR--LGPGKTIVTILPDSG---ERY 298
|
|
| PRK12483 |
PRK12483 |
threonine dehydratase; Reviewed |
64-226 |
3.76e-21 |
|
threonine dehydratase; Reviewed
Pssm-ID: 237111 [Multi-domain] Cd Length: 521 Bit Score: 94.86 E-value: 3.76e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 64 DTPLTRAKKLSKELGIELYLKNETINPTWSFKDRGTYLGIHR--AIQLDfRRIGTVSTGNMAASVAAYGAHSELEVYILV 141
Cdd:PRK12483 37 ETPLQRAPNLSARLGNQVLLKREDLQPVFSFKIRGAYNKMARlpAEQLA-RGVITASAGNHAQGVALAAARLGVKAVIVM 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 142 SSTIPEEKIKALAPYGAKIVkVHGD-YGELYYRALEIGQKKGIYFINS-DDPFRVEGYKSISFEI-SEEITP-DYVIVPT 217
Cdd:PRK12483 116 PRTTPQLKVDGVRAHGGEVV-LHGEsFPDALAHALKLAEEEGLTFVPPfDDPDVIAGQGTVAMEIlRQHPGPlDAIFVPV 194
|
....*....
gi 499321828 218 SSGGLFRGI 226
Cdd:PRK12483 195 GGGGLIAGI 203
|
|
| PRK06815 |
PRK06815 |
threonine/serine dehydratase; |
65-363 |
3.08e-19 |
|
threonine/serine dehydratase;
Pssm-ID: 180709 [Multi-domain] Cd Length: 317 Bit Score: 87.44 E-value: 3.08e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 65 TPLTRAKKLSKELGIELYLKNETINPTWSFKDRGTyLGIHRAIQLDFRRIG--TVSTGNMAASVAAYGAHSELEVYILVS 142
Cdd:PRK06815 21 TPLEHSPLLSQHTGCEVYLKCEHLQHTGSFKFRGA-SNKLRLLNEAQRQQGviTASSGNHGQGVALAAKLAGIPVTVYAP 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 143 STIPEEKIKALAPYGAKIVKVHGD--YGELYYRALeiGQKKGIYFINS-DDPFRVEGYKSISFEISEEI-TPDYVIVPTS 218
Cdd:PRK06815 100 EQASAIKLDAIRALGAEVRLYGGDalNAELAARRA--AEQQGKVYISPyNDPQVIAGQGTIGMELVEQQpDLDAVFVAVG 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 219 SGGLFRGIvKGFLEAKNSGlieklprffvVQAEGCSPI-----CKAFNAGkeKIERFENPHTI----AHAIEnpyppSGN 289
Cdd:PRK06815 178 GGGLISGI-ATYLKTLSPK----------TEIIGCWPAnspslYTSLEAG--EIVEVAEQPTLsdgtAGGVE-----PGA 239
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 499321828 290 AVLRLLKKLNGICTTVTDEEILEA-QKILGREGIFVQLASATGIAAVKKLRRKgiiKEGAIVVSILTGS--GLKTLR 363
Cdd:PRK06815 240 ITFPLCQQLIDQKVLVSEEEIKEAmRLIAETDRWLIEGAAGVALAAALKLAPR---YQGKKVAVVLCGKniVLEKYL 313
|
|
| PRK08639 |
PRK08639 |
threonine dehydratase; Validated |
65-375 |
1.12e-18 |
|
threonine dehydratase; Validated
Pssm-ID: 236318 [Multi-domain] Cd Length: 420 Bit Score: 86.78 E-value: 1.12e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 65 TPLTRAKKLSKELGIELYLKNETINPTWSFKDRGTYLGIHRAIQLDfRRIGTV--STGNMAASVaAYGAHsELEVY--IL 140
Cdd:PRK08639 26 TPLQRNDYLSEKYGANVYLKREDLQPVRSYKLRGAYNAISQLSDEE-LAAGVVcaSAGNHAQGV-AYACR-HLGIPgvIF 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 141 VSSTIPEEKIKALAPYGAKIVKVH--GD-YGELYYRALEIGQKKGIYFINS-DDPFRVEGYKSISFEI----SEEITPDY 212
Cdd:PRK08639 103 MPVTTPQQKIDQVRFFGGEFVEIVlvGDtFDDSAAAAQEYAEETGATFIPPfDDPDVIAGQGTVAVEIleqlEKEGSPDY 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 213 VIVPTSSGGLFRGIVkGFLEaknsgliEKLP--RFFVVQAEGCSPICKAFNAGK----EKIERFENphtiahaienpypp 286
Cdd:PRK08639 183 VFVPVGGGGLISGVT-TYLK-------ERSPktKIIGVEPAGAASMKAALEAGKpvtlEKIDKFVD-------------- 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 287 sGNAVLR-------LLKKL---------NGICTTvtdeeILEaqkILGREGIFVQLASATGIAAVKKLRRKgiIKeGAIV 350
Cdd:PRK08639 241 -GAAVARvgdltfeILKDVvddvvlvpeGAVCTT-----ILE---LYNKEGIVAEPAGALSIAALELYKDE--IK-GKTV 308
|
330 340
....*....|....*....|....*
gi 499321828 351 VSILTGSGLKTLRYikqPKVEECSL 375
Cdd:PRK08639 309 VCVISGGNNDIERM---PEIKERSL 330
|
|
| L-Ser-dehyd |
cd06448 |
Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the ... |
65-358 |
1.62e-18 |
|
Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- , D-serine, or L-threonine to pyruvate/ketobutyrate and ammonia.
Pssm-ID: 107209 Cd Length: 316 Bit Score: 85.43 E-value: 1.62e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 65 TPLTRAKKLSKELGIELYLKNETINPTWSFKDRGTYLGIHRAIQLDFRRIGTV--STGNMAASVAAYGAHS-ELEVYILV 141
Cdd:cd06448 2 TPLIESTALSKTAGCNVFLKLENLQPSGSFKIRGIGHLCQKSAKQGLNECVHVvcSSGGNAGLAAAYAARKlGVPCTIVV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 142 SSTIPEEKIKALAPYGAKIVKVHGDYGEL--YYRALEIGQKKG-IYFINSDDPFRVEGYKSISFEISEEI----TPDYVI 214
Cdd:cd06448 82 PESTKPRVVEKLRDEGATVVVHGKVWWEAdnYLREELAENDPGpVYVHPFDDPLIWEGHSSMVDEIAQQLqsqeKVDAIV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 215 VPTSSGGLFRGIVKGFleaKNSGLIEklPRFFVVQAEGCSPICKAFNAGK----EKIErfenphTIAHAIENPYppSGNA 290
Cdd:cd06448 162 CSVGGGGLLNGIVQGL---ERNGWGD--IPVVAVETEGAHSLNASLKAGKlvtlPKIT------SVATSLGAKT--VSSQ 228
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 499321828 291 VLRLLKKLNGICTTVTDEEILEA-QKILGREGIFVQLASATGIAAV---KKLRRKGIIKEGA---IVVSILTGSG 358
Cdd:cd06448 229 ALEYAQEHNIKSEVVSDRDAVQAcLRFADDERILVEPACGAALAVVysgKILDLQLEVLLTPldnVVVVVCGGSN 303
|
|
| PLN02970 |
PLN02970 |
serine racemase |
65-356 |
2.53e-18 |
|
serine racemase
Pssm-ID: 215524 [Multi-domain] Cd Length: 328 Bit Score: 84.73 E-value: 2.53e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 65 TPLTRAKKLSKELGIELYLKNETINPTWSFKDRGTYLGIHRAIQLDFRR-IGTVSTGNMAASVAAYGAHSELEVYILVSS 143
Cdd:PLN02970 28 TPVLTSSSLDALAGRSLFFKCECFQKGGAFKFRGACNAIFSLSDDQAEKgVVTHSSGNHAAALALAAKLRGIPAYIVVPK 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 144 TIPEEKIKALAPYGAKIVKVHGDYGELYYRALEIGQKKGIYFIN-SDDPFRVEGYKSISFEISEEITP-DYVIVPTSSGG 221
Cdd:PLN02970 108 NAPACKVDAVIRYGGIITWCEPTVESREAVAARVQQETGAVLIHpYNDGRVISGQGTIALEFLEQVPElDVIIVPISGGG 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 222 LFRGIVkgfLEAKNsglIEKLPRFFVVQAEGCSPICKAFNAGkeKIERFENPHTIAHAIENPYPPSGNAVLRLLkkLNGI 301
Cdd:PLN02970 188 LISGIA---LAAKA---IKPSIKIIAAEPKGADDAAQSKAAG--EIITLPVTNTIADGLRASLGDLTWPVVRDL--VDDV 257
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 499321828 302 cTTVTDEEILEAQKILG-REGIFVQLASATGIAAV--KKLRRKGIIKEGAIVVSILTG 356
Cdd:PLN02970 258 -ITVDDKEIIEAMKLCYeRLKVVVEPSGAIGLAAAlsDSFRSNPAWKGCKNVGIVLSG 314
|
|
| PRK09224 |
PRK09224 |
threonine ammonia-lyase IlvA; |
65-226 |
2.86e-17 |
|
threonine ammonia-lyase IlvA;
Pssm-ID: 236417 [Multi-domain] Cd Length: 504 Bit Score: 83.26 E-value: 2.86e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 65 TPLTRAKKLSKELGIELYLKNETINPTWSFKDRGTYlgiHRAIQL--DFRRIG--TVSTGNMAASVAAYGAHSELEVYIL 140
Cdd:PRK09224 21 TPLEKAPKLSARLGNQVLLKREDLQPVFSFKLRGAY---NKMAQLteEQLARGviTASAGNHAQGVALSAARLGIKAVIV 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 141 VSSTIPEEKIKALAPYGAKIVkVHGD-YGELYYRALEIGQKKGIYFINS-DDPFRVEGYKSISFEISEEIT--PDYVIVP 216
Cdd:PRK09224 98 MPVTTPDIKVDAVRAFGGEVV-LHGDsFDEAYAHAIELAEEEGLTFIHPfDDPDVIAGQGTIAMEILQQHPhpLDAVFVP 176
|
170
....*....|
gi 499321828 217 TSSGGLFRGI 226
Cdd:PRK09224 177 VGGGGLIAGV 186
|
|
| PRK08813 |
PRK08813 |
threonine dehydratase; Provisional |
65-356 |
2.02e-15 |
|
threonine dehydratase; Provisional
Pssm-ID: 236339 [Multi-domain] Cd Length: 349 Bit Score: 76.59 E-value: 2.02e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 65 TPLTRAKKLSkelgieLYLKNETINPTWSFKDRGTY----LGIHRAiqlDFRRIGTVSTGNMAASVAAYGAHSELEVYIL 140
Cdd:PRK08813 40 TPLHYAERFG------VWLKLENLQRTGSYKVRGALnallAGLERG---DERPVICASAGNHAQGVAWSAYRLGVQAITV 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 141 VSSTIPEEKIKALAPYGAKiVKVHGD-YGELYYRALEIGQKKGIYFINS-DDPFRVEGYKSISFEISEEiTPDYVIVPTS 218
Cdd:PRK08813 111 MPHGAPQTKIAGVAHWGAT-VRQHGNsYDEAYAFARELADQNGYRFLSAfDDPDVIAGQGTVGIELAAH-APDVVIVPIG 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 219 SGGLFRGIVkgfLEAKNSGLieklpRFFVVQAEGCSPICKAFNAGKEKIERFEnphTIAHAIENPYPpsGNAVLRLLKKL 298
Cdd:PRK08813 189 GGGLASGVA---LALKSQGV-----RVVGAQVEGVDSMARAIRGDLREIAPVA---TLADGVKVKIP--GFLTRRLCSSL 255
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 499321828 299 NGICTTVTDEEILEAQ-KILGREGIFVQLASATGIAAVKKL---RRKGIIKEGAIVVSILTG 356
Cdd:PRK08813 256 LDDVVIVREAELRETLvRLALEEHVIAEGAGALALAAGRRVsgkRKCAVVSGGNIDATVLAT 317
|
|
| eutB |
PRK07476 |
threonine dehydratase; Provisional |
65-229 |
2.20e-15 |
|
threonine dehydratase; Provisional
Pssm-ID: 236025 [Multi-domain] Cd Length: 322 Bit Score: 76.16 E-value: 2.20e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 65 TPLTRAKKLSKELGIELYLKNETINPTWSFKDRG-TYLGIHRAIQLDFRRIGTVSTGNMAASVAAYGAHSELEVYILVSS 143
Cdd:PRK07476 20 TPLVASASLSARAGVPVWLKLETLQPTGSFKLRGaTNALLSLSAQERARGVVTASTGNHGRALAYAARALGIRATICMSR 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 144 TIPEEKIKALAPYGAKIVKVHGDYGELYYRALEIGQKKGIYFINS-DDPFRVEGYKSISFEISEEItPD--YVIVPTSSG 220
Cdd:PRK07476 100 LVPANKVDAIRALGAEVRIVGRSQDDAQAEVERLVREEGLTMVPPfDDPRIIAGQGTIGLEILEAL-PDvaTVLVPLSGG 178
|
170
....*....|..
gi 499321828 221 GLFRGI---VKG 229
Cdd:PRK07476 179 GLASGVaaaVKA 190
|
|
| PLN02550 |
PLN02550 |
threonine dehydratase |
64-226 |
2.32e-15 |
|
threonine dehydratase
Pssm-ID: 178165 [Multi-domain] Cd Length: 591 Bit Score: 77.65 E-value: 2.32e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 64 DTPLTRAKKLSKELGIELYLKNETINPTWSFKDRGTYLGIHR--AIQLDfRRIGTVSTGNMAASVAAYGAHSELEVYILV 141
Cdd:PLN02550 109 ESPLQLAKKLSERLGVKVLLKREDLQPVFSFKLRGAYNMMAKlpKEQLD-KGVICSSAGNHAQGVALSAQRLGCDAVIAM 187
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 142 SSTIPEEKIKALAPYGAKIVKVHGDYGELYYRALEIGQKKGIYFINS-DDPFRVEGYKSISFEISEEIT-PDYVI-VPTS 218
Cdd:PLN02550 188 PVTTPEIKWQSVERLGATVVLVGDSYDEAQAYAKQRALEEGRTFIPPfDHPDVIAGQGTVGMEIVRQHQgPLHAIfVPVG 267
|
....*...
gi 499321828 219 SGGLFRGI 226
Cdd:PLN02550 268 GGGLIAGI 275
|
|
| PRK08246 |
PRK08246 |
serine/threonine dehydratase; |
80-335 |
4.60e-15 |
|
serine/threonine dehydratase;
Pssm-ID: 181319 [Multi-domain] Cd Length: 310 Bit Score: 74.99 E-value: 4.60e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 80 ELYLKNETINPTWSFKDRGTYlgiHRAIQLDFRRIGTV--STGNMAASVAAYGAHSELEVYILVSSTIPEEKIKALAPYG 157
Cdd:PRK08246 38 PVWLKLEHLQHTGSFKARGAF---NRLLAAPVPAAGVVaaSGGNAGLAVAYAAAALGVPATVFVPETAPPAKVARLRALG 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 158 AKIVKVHGDYGELYYRALEIGQKKGIYFINS-DDPFRVEGYKSISFEISEEI-TPDYVIVPTSSGGLFRGIVKGFleakn 235
Cdd:PRK08246 115 AEVVVVGAEYADALEAAQAFAAETGALLCHAyDQPEVLAGAGTLGLEIEEQApGVDTVLVAVGGGGLIAGIAAWF----- 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 236 sgliEKLPRFFVVQAEGCSPICKAFNAGKekierfenphtiahaienPY--PPSGNA------------VLRLLKKLNGI 301
Cdd:PRK08246 190 ----EGRARVVAVEPEGAPTLHAALAAGE------------------PVdvPVSGIAadslgarrvgeiAFALARAHVVT 247
|
250 260 270
....*....|....*....|....*....|....*
gi 499321828 302 CTTVTDEEILEAQKILGRE-GIFVQLASATGIAAV 335
Cdd:PRK08246 248 SVLVSDEAIIAARRALWEElRLAVEPGAATALAAL 282
|
|
| PRK07048 |
PRK07048 |
threo-3-hydroxy-L-aspartate ammonia-lyase; |
65-350 |
8.12e-15 |
|
threo-3-hydroxy-L-aspartate ammonia-lyase;
Pssm-ID: 235918 [Multi-domain] Cd Length: 321 Bit Score: 74.67 E-value: 8.12e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 65 TPLTRAKKLSKELGIELYLKNETINPTWSFKDRGTYLGIHR--AIQldfRRIGTV--STGNMAASVAAYGAHSELEVYIL 140
Cdd:PRK07048 25 TPVLTSRTADARTGAQVFFKCENFQRMGAFKFRGAYNALSQfsPEQ---RRAGVVtfSSGNHAQAIALSARLLGIPATIV 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 141 VSSTIPEEKIKALAPYGAKIVkvhgdygeLYYR--------ALEIGQKKGIYFINS-DDPFRVEGYKSISFEISEEITP- 210
Cdd:PRK07048 102 MPQDAPAAKVAATRGYGGEVV--------TYDRytedreeiGRRLAEERGLTLIPPyDHPHVIAGQGTAAKELFEEVGPl 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 211 DYVIVPTSSGGLFRGIVkgfleaknsglieklprffvVQAEGCSPICKAFN----AG--------KEKIERFENPHTIAH 278
Cdd:PRK07048 174 DALFVCLGGGGLLSGCA--------------------LAARALSPGCKVYGvepeAGndgqqsfrSGEIVHIDTPRTIAD 233
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 499321828 279 AIENPYppSGNAVLRLLKKLNGICTTVTDEEILEAQKIL-GREGIFVQLASATGIAAVKKL------RRKGIIKEGAIV 350
Cdd:PRK07048 234 GAQTQH--LGNYTFPIIRRLVDDIVTVSDAELVDAMRFFaERMKIVVEPTGCLGAAAALRGkvplkgKRVGVIISGGNV 310
|
|
| PRK07334 |
PRK07334 |
threonine dehydratase; Provisional |
64-226 |
6.77e-14 |
|
threonine dehydratase; Provisional
Pssm-ID: 235994 [Multi-domain] Cd Length: 403 Bit Score: 72.62 E-value: 6.77e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 64 DTPLTRAKKLSKELGIELYLKNETINPTWSFKDRGtylGIHRAIQL--DFRRIG--TVSTGNMAASVAAYGAHSELEVYI 139
Cdd:PRK07334 23 RTPCVHSRTLSQITGAEVWLKFENLQFTASFKERG---ALNKLLLLteEERARGviAMSAGNHAQGVAYHAQRLGIPATI 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 140 LVSSTIPEEKIKALAPYGAKIVkVHGD-YGELYYRALEIGQKKGIYFINS-DDPFRVEGYKSISFEISEEITP-DYVIVP 216
Cdd:PRK07334 100 VMPRFTPTVKVERTRGFGAEVV-LHGEtLDEARAHARELAEEEGLTFVHPyDDPAVIAGQGTVALEMLEDAPDlDTLVVP 178
|
170
....*....|
gi 499321828 217 TSSGGLFRGI 226
Cdd:PRK07334 179 IGGGGLISGM 188
|
|
| cysKM |
TIGR01136 |
cysteine synthase; This model discriminates cysteine synthases (EC 2.5.1.47) (both CysK and ... |
63-362 |
1.02e-10 |
|
cysteine synthase; This model discriminates cysteine synthases (EC 2.5.1.47) (both CysK and CysM) from cystathionine beta-synthase, a protein found primarily in eukaryotes and carrying a C-terminal CBS domain lacking from this protein. Bacterial proteins lacking the CBS domain but otherwise showing resemblamnce to cystathionine beta-synthases and considerable phylogenetic distance from known cysteine synthases were excluded from the seed and score below the trusted cutoff. [Amino acid biosynthesis, Serine family]
Pssm-ID: 273463 Cd Length: 299 Bit Score: 61.91 E-value: 1.02e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 63 GDTPLTRAKKLSKELGIELYLKNETINPTWSFKDRGTYLGIHRAIQLDFRRIGTV----STGNMAASVAAYGAHSELEVY 138
Cdd:TIGR01136 6 GNTPLVRLNRLAPGCDARVLAKLEGFNPSGSVKDRIALSMILDAEKRGLLKPGDTiieaTSGNTGIALAMVAAARGYKLI 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 139 ILVSSTIPEEKIKALAPYGAKIVKVHGDYGEL--YYRALEIGQKKGIYFI-----NSDDPFrvEGYKSISFEISEEITP- 210
Cdd:TIGR01136 86 LTMPETMSLERRKLLRAYGAELILTPGEEGMKgaIDKAEELAAETNKYVMldqfeNPANPE--AHYKTTGPEIWRDTDGr 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 211 -DYVIVPTSSGGLFRGIvkgfleakNSGLIEKLPRFFVVQAEGC-SPICKAFNAGKEKIERfenphtiahaIENPYPPsG 288
Cdd:TIGR01136 164 iDHFVAGVGTGGTITGV--------GRYLKEQNPNIQIVAVEPAeSPVLSGGEPGPHKIQG----------IGAGFIP-K 224
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 499321828 289 NAVLRLLKKLngicTTVTDEEILEAQKILGR-EGIFVQLASATGIAAVKKLrRKGIIKEGAIVVSILTGSGLKTL 362
Cdd:TIGR01136 225 ILDLSLIDEV----ITVSDEDAIETARRLAReEGILVGISSGAAVAAALKL-AKRLENADKVIVAILPDTGERYL 294
|
|
| Trp-synth_B |
cd06446 |
Tryptophan synthase-beta: Tryptophan synthase is a bifunctional enzyme that catalyses the ... |
44-365 |
1.61e-10 |
|
Tryptophan synthase-beta: Tryptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to glyceraldehyde 3-phosphate and indole at the active site of the alpha subunit. In the beta reaction, indole undergoes a PLP-dependent reaction with L-serine to form L-tryptophan at the active site of the beta subunit. Members of this CD, Trp-synth_B, are found in all three major phylogenetic divisions.
Pssm-ID: 107207 Cd Length: 365 Bit Score: 61.78 E-value: 1.61e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 44 ERFSEFFPLELDPELSLGEG-DTPLTRAKKLSKEL-GIELYLKNETINPTWSFKdrgtylgIHRAI-Q-LDFRRIG---- 115
Cdd:cd06446 13 ERYDPDFPEELRELYKDYVGrPTPLYRAKRLSEYLgGAKIYLKREDLNHTGAHK-------INNALgQaLLAKRMGkkrv 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 116 TVSTG----NMAASVAAYGAHSELEVYILvsstipEEKIKALAP-------YGAKIVKVHGDYGEL---------YYRAL 175
Cdd:cd06446 86 IAETGagqhGVATATACALFGLECEIYMG------AVDVERQPLnvfrmelLGAEVVPVPSGSGTLkdaiseairDWVTN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 176 EIGQKkgiYFINS---DDPFR--VEGYKSIsfeISEEI----------TPDYVIVPTSSGGLFRGIVKGFLEAKNsglie 240
Cdd:cd06446 160 VEDTH---YLLGSvvgPHPYPnmVRDFQSV---IGEEAkkqilekegeLPDVVIACVGGGSNAAGLFYPFINDKD----- 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 241 klPRFFVVQAEGCsPI-----CKAFNAGKEKI-------------ERFENPHTIAHAIEnpYPPSGnAVLRLLKKLNGIC 302
Cdd:cd06446 229 --VKLIGVEAGGC-GLetgghAAYLFGGTAGVlhglkmytlqdedGQIVPPHSISAGLD--YPGVG-PEHAYLKDSGRVE 302
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 499321828 303 -TTVTDEEILEAQKILGR-EGIFVQLASATGIAAVKKLRRKGiiKEGAIVVSILTGSGLKTLRYI 365
Cdd:cd06446 303 yVAVTDEEALEAFKLLARtEGIIPALESSHAIAYAIKLAKKL--GKEKVIVVNLSGRGDKDLQTV 365
|
|
| PRK06608 |
PRK06608 |
serine/threonine dehydratase; |
65-225 |
3.05e-09 |
|
serine/threonine dehydratase;
Pssm-ID: 235842 [Multi-domain] Cd Length: 338 Bit Score: 57.86 E-value: 3.05e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 65 TPLTRAKKLSKELGIELYLKNETINPTWSFKDRGTyLGIHRAIQLDFR---RIGTVSTGNMAASVAAYGAHSELEVYILV 141
Cdd:PRK06608 24 TPIVHSESLNEMLGHEIFFKVESLQKTGAFKVRGV-LNHLLELKEQGKlpdKIVAYSTGNHGQAVAYASKLFGIKTRIYL 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 142 SSTIPEEKIKALAPYGAKiVKVHGDYGELYYRALEiGQKKGIYFIN-SDDPFRVEGYKSISFEISEEI--TPDYVIVPTS 218
Cdd:PRK06608 103 PLNTSKVKQQAALYYGGE-VILTNTRQEAEEKAKE-DEEQGFYYIHpSDSDSTIAGAGTLCYEALQQLgfSPDAIFASCG 180
|
....*..
gi 499321828 219 SGGLFRG 225
Cdd:PRK06608 181 GGGLISG 187
|
|
| PLN02356 |
PLN02356 |
phosphateglycerate kinase |
63-369 |
1.41e-07 |
|
phosphateglycerate kinase
Pssm-ID: 215204 Cd Length: 423 Bit Score: 53.07 E-value: 1.41e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 63 GDTPLTRAKKLSKELGIELYLKNETINPTWSFKDRGTYLGIHRAIQLDFRRIGTV----STGNMAASVAAYGAHSELEVY 138
Cdd:PLN02356 52 GNTPLIRINSLSEATGCEILGKCEFLNPGGSVKDRVAVKIIEEALESGQLFPGGVvtegSAGSTAISLATVAPAYGCKCH 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 139 ILVSSTIPEEKIKALAPYGAKIVKV------HGD-YGELYYR----ALEIGQKKGIYF-INSDDPFRVEGYksisfeISE 206
Cdd:PLN02356 132 VVIPDDVAIEKSQILEALGATVERVrpvsitHKDhYVNIARRraleANELASKRRKGSeTDGIHLEKTNGC------ISE 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 207 EITPDYVIVPTSSGGLF-------------------------RGIVKGFLEAKNSG---------LIEKLPRF--FVVQA 250
Cdd:PLN02356 206 EEKENSLFSSSCTGGFFadqfenlanfrahyegtgpeiweqtQGNLDAFVAAAGTGgtlagvsrfLQEKNPNIkcFLIDP 285
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 251 EGC---SPICKAFNAGKEKIE--RFENP-HTIAHAIenpyppsgnAVLRLLK-----KLNGICTTvTDEEILEAQK-ILG 318
Cdd:PLN02356 286 PGSglfNKVTRGVMYTREEAEgrRLKNPfDTITEGI---------GINRLTQnflmaKLDGAFRG-TDKEAVEMSRyLLK 355
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 499321828 319 REGIFVqlASATGIAAVKKLRRKGIIKEGAIVVSILTGSGLKTLRYIKQPK 369
Cdd:PLN02356 356 NDGLFV--GSSSAMNCVGAVRVAQSLGPGHTIVTILCDSGMRHLSKFHDPQ 404
|
|
| PRK13803 |
PRK13803 |
bifunctional phosphoribosylanthranilate isomerase/tryptophan synthase subunit beta; Provisional |
65-360 |
2.17e-07 |
|
bifunctional phosphoribosylanthranilate isomerase/tryptophan synthase subunit beta; Provisional
Pssm-ID: 237513 [Multi-domain] Cd Length: 610 Bit Score: 52.89 E-value: 2.17e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 65 TPLTRAKKLSKELGIELYLKNETINPTWSFKDRGTYLGIHRAIQLDFRRI----GTVSTGNMAASVAAYgahSELEVYIL 140
Cdd:PRK13803 272 TPLTEAKRLSDIYGARIYLKREDLNHTGSHKINNALGQALLAKRMGKTRIiaetGAGQHGVATATACAL---FGLKCTIF 348
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 141 VSstipEEKIKALAP-------YGAKIVKVHGDYGEL------YYRALEIGQKKGIYFINS---DDPF--RVEGYKSIsf 202
Cdd:PRK13803 349 MG----EEDIKRQALnvermklLGANVIPVLSGSKTLkdavneAIRDWVASVPDTHYLIGSavgPHPYpeMVAYFQSV-- 422
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 203 eISEEIT----------PDYVIVPTSSGGLFRGIVKGFLEAKNSGLIEklprffvVQAEGcspicKAFNAGK-------- 264
Cdd:PRK13803 423 -IGEEAKeqlkeqtgklPDAIIACVGGGSNAIGIFYHFLDDPSVKLIG-------VEAGG-----KGVNTGEhaatikkg 489
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 265 --------------EKIERFENPHTIAHAIEnpYPPSG--NAVLRLLKKLNGIctTVTDEEILEAQKILGR-EGIFVQLA 327
Cdd:PRK13803 490 rkgvlhgsmtylmqDENGQILEPHSISAGLD--YPGIGpmHANLFETGRAIYT--SVTDEEALDAFKLLAKlEGIIPALE 565
|
330 340 350
....*....|....*....|....*....|...
gi 499321828 328 SATGIAAVKKLRRKgiIKEGAIVVSILTGSGLK 360
Cdd:PRK13803 566 SSHALAYLKEGRKK--FKKKDIVIVNLSGRGDK 596
|
|
| PRK06110 |
PRK06110 |
threonine dehydratase; |
65-356 |
2.69e-07 |
|
threonine dehydratase;
Pssm-ID: 235699 Cd Length: 322 Bit Score: 51.92 E-value: 2.69e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 65 TPLTRAKKLSKELGIELYLKNETINPTWSFKDRG--TYLGIHRAIQLDFRRIGTVSTGNMAASVAAYGAHSELEVYILVS 142
Cdd:PRK06110 22 TPQYRWPLLAERLGCEVWVKHENHTPTGAFKVRGglVYFDRLARRGPRVRGVISATRGNHGQSVAFAARRHGLAATIVVP 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 143 STIPEEKIKALAPYGAKIVKvHG-DYGELYYRALEIGQKKGIYFINSDDPFRVEGYKSISFEISEEITP-DYVIVPTssg 220
Cdd:PRK06110 102 HGNSVEKNAAMRALGAELIE-HGeDFQAAREEAARLAAERGLHMVPSFHPDLVRGVATYALELFRAVPDlDVVYVPI--- 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 221 GLFRGIVkGFLEAKNS-GLIEklpRFFVVQAEGCSPICKAFNAGkEKIERfENPHTIAHAIENPYP-PSGNAVLRllKKL 298
Cdd:PRK06110 178 GMGSGIC-GAIAARDAlGLKT---RIVGVVSAHAPAYALSFEAG-RVVTT-PVATTLADGMACRTPdPEALEVIR--AGA 249
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 499321828 299 NGIcTTVTDEEILEAQKILGR------EGifvqlASATGIAAVKKLRRKgiiKEGAIVVSILTG 356
Cdd:PRK06110 250 DRI-VRVTDDEVAAAMRAYFTdthnvaEG-----AGAAALAAALQERER---LAGKRVGLVLSG 304
|
|
| cysM |
PRK11761 |
cysteine synthase CysM; |
63-191 |
7.72e-06 |
|
cysteine synthase CysM;
Pssm-ID: 236972 Cd Length: 296 Bit Score: 47.18 E-value: 7.72e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 63 GDTPLTRAKKLSKELGIELYLKNETINPTWSFKDRGTYLGIHRAIQLDFRRIGTV----STGN------MAASVAAYGah 132
Cdd:PRK11761 11 GNTPLVKLQRLPPDRGNTILAKLEGNNPAGSVKDRPALSMIVQAEKRGEIKPGDTlieaTSGNtgialaMIAAIKGYR-- 88
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 133 selevYILVsstIPE----EKIKALAPYGAKIVKVHGDYGELYYR--ALEIgQKKGIYFI-----NSDDP 191
Cdd:PRK11761 89 -----MKLI---MPEnmsqERRAAMRAYGAELILVPKEQGMEGARdlALQM-QAEGEGKVldqfaNPDNP 149
|
|
| PRK10717 |
PRK10717 |
cysteine synthase A; Provisional |
63-163 |
8.49e-05 |
|
cysteine synthase A; Provisional
Pssm-ID: 182672 [Multi-domain] Cd Length: 330 Bit Score: 44.08 E-value: 8.49e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499321828 63 GDTPLTRAKKLSKELGIELYLKNETINPTWSFKDRGTYLGIHRAI-QLDFRRIGTV---STGN----MAASVAAYGAHSE 134
Cdd:PRK10717 12 GNTPLIRLNRASEATGCEILGKAEFLNPGGSVKDRAALNIIWDAEkRGLLKPGGTIvegTAGNtgigLALVAAARGYKTV 91
|
90 100 110
....*....|....*....|....*....|...
gi 499321828 135 LevyilvssTIPE----EKIKALAPYGAKIVKV 163
Cdd:PRK10717 92 I--------VMPEtqsqEKKDLLRALGAELVLV 116
|
|
| PRK04346 |
PRK04346 |
tryptophan synthase subunit beta; Validated |
303-360 |
4.35e-03 |
|
tryptophan synthase subunit beta; Validated
Pssm-ID: 235288 Cd Length: 397 Bit Score: 38.89 E-value: 4.35e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 499321828 303 TTVTDEEILEAQKILGR-EGIFVQLASATGIAAVKKLRRKgIIKEGAIVVSiLTGSGLK 360
Cdd:PRK04346 328 VSITDDEALEAFQLLSRlEGIIPALESSHALAYALKLAPT-LGKDQIIVVN-LSGRGDK 384
|
|
| |
