NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|499349711|ref|WP_011039004|]
View 

ATP/GTP-binding protein [Xanthomonas campestris]

Protein Classification

GTP-binding protein( domain architecture ID 10006198)

GTP-binding protein similar to mutual gliding-mobilty protein MglA, a GTPase that is critical for single-cell (A) gliding, type IV pili-mediated (S) gliding and development of Myxococcus xanthus

CATH:  3.30.450.30
EC:  3.6.5.-
Gene Ontology:  GO:0005525|GO:0003924
PubMed:  11152757
SCOP:  3002022

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Srp102 COG2229
Signal recognition particle receptor subunit beta, a GTPase [Intracellular trafficking, ...
 7-178 1.77e-51

Signal recognition particle receptor subunit beta, a GTPase [Intracellular trafficking, secretion, and vesicular transport];


:

Pssm-ID: 441830 [Multi-domain]  Cd Length: 189  Bit Score: 163.07  E-value: 1.77e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349711   7 KLVFVGGMGAGKTTAVRAISDVEPVSTEMPLSQDAYGDKTYTTVALDYSSIELEDGELLHVYGVPGQKYLDFMWPLVCDG 86
Cdd:COG2229   14 KIVYAGPFGAGKTTFVRSISEIEPLSTEGRLTDASLETKTTTTVAFDFGRLTLGDGLRLHLFGTPGQVRFDFMWDILLRG 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349711  87 ALGVIVLTSARDTQMRDtTLELLREFSRITPEASLAVGVTMTDEVQEFLLPPFREALvAEGFRIPVMRVDARSATQITFL 166
Cdd:COG2229   94 ADGVVFLADSRRLEDSF-NAESLDFFEERLEKLPFVVAVNKRDLPDALSLEELREAL-DLGPDVPVVEADARDGESVKET 171

                        170
                 ....*....|..
gi 499349711 167 VKTLLSYRYTSA 178
Cdd:COG2229  172 LIALLELVLARL 183
 
Name Accession Description Interval E-value
Srp102 COG2229
Signal recognition particle receptor subunit beta, a GTPase [Intracellular trafficking, ...
 7-178 1.77e-51

Signal recognition particle receptor subunit beta, a GTPase [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 441830 [Multi-domain]  Cd Length: 189  Bit Score: 163.07  E-value: 1.77e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349711   7 KLVFVGGMGAGKTTAVRAISDVEPVSTEMPLSQDAYGDKTYTTVALDYSSIELEDGELLHVYGVPGQKYLDFMWPLVCDG 86
Cdd:COG2229   14 KIVYAGPFGAGKTTFVRSISEIEPLSTEGRLTDASLETKTTTTVAFDFGRLTLGDGLRLHLFGTPGQVRFDFMWDILLRG 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349711  87 ALGVIVLTSARDTQMRDtTLELLREFSRITPEASLAVGVTMTDEVQEFLLPPFREALvAEGFRIPVMRVDARSATQITFL 166
Cdd:COG2229   94 ADGVVFLADSRRLEDSF-NAESLDFFEERLEKLPFVVAVNKRDLPDALSLEELREAL-DLGPDVPVVEADARDGESVKET 171

                        170
                 ....*....|..
gi 499349711 167 VKTLLSYRYTSA 178
Cdd:COG2229  172 LIALLELVLARL 183
ATP_bind_1 pfam03029
Conserved hypothetical ATP binding protein; Members of this family are found in a range of ...
 10-93 1.43e-06

Conserved hypothetical ATP binding protein; Members of this family are found in a range of archaea and eukaryotes and have hypothesized ATP binding activity.


Pssm-ID: 397252 [Multi-domain]  Cd Length: 238  Bit Score: 46.60  E-value: 1.43e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349711   10 FVGGMGAGKTTAVRAISDV-----------------------------EPVSTEMPLSQDAYGDKTYTTVALDYSSIELE 60
Cdd:pfam03029   1 VVGPAGSGKTTFVGALSEIlplrgrpvyvvnldpaaenlpypadidirELITVADVMEDYGLGPNGALTVAMDFGRITLD 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 499349711   61 --DGEL-----LHVYGVPGQKYLDFMWP--------LVCDGALGVIVL 93
Cdd:pfam03029  81 wlDEELkreddYYLFDTPGQIELFTHWDslaiiveaLESRGALGAVYL 128
Ras_like_GTPase cd00882
Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like ...
 9-172 1.21e-05

Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras, Rho, Rab, and Sar1/Arf families. This superfamily also includes proteins like the GTP translation factors, Era-like GTPases, and G-alpha chain of the heterotrimeric G proteins. Members of the Ras superfamily regulate a wide variety of cellular functions: the Ras family regulates gene expression, the Rho family regulates cytoskeletal reorganization and gene expression, the Rab and Sar1/Arf families regulate vesicle trafficking, and the Ran family regulates nucleocytoplasmic transport and microtubule organization. The GTP translation factor family regulates initiation, elongation, termination, and release in translation, and the Era-like GTPase family regulates cell division, sporulation, and DNA replication. Members of the Ras superfamily are identified by the GTP binding site, which is made up of five characteristic sequence motifs, and the switch I and switch II regions.


Pssm-ID: 206648 [Multi-domain]  Cd Length: 161  Bit Score: 43.21  E-value: 1.21e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349711   9 VFVGGMGAGKTTAVRAI--SDVEPVSTEMPlsqdaygdktyTTVALDYSSIELE-DGELLHVYGVPGQKYLDFMWP---- 81
Cdd:cd00882    1 VVVGRGGVGKSSLLNALlgGEVGEVSDVPG-----------TTRDPDVYVKELDkGKVKLVLVDTPGLDEFGGLGReela 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349711  82 -LVCDGALGVIVLTSARDTQMRDTTLELLREFSRITPEASLAVGvTMTDEVQEFLLPPFREALVAEGF-RIPVMRVDARS 159
Cdd:cd00882   70 rLLLRGADLILLVVDSTDRESEEDAKLLILRRLRKEGIPIILVG-NKIDLLEEREVEELLRLEELAKIlGVPVFEVSAKT 148

                        170
                 ....*....|...
gi 499349711 160 ATQITFLVKTLLS 172
Cdd:cd00882  149 GEGVDELFEKLIE 161
 
Name Accession Description Interval E-value
Srp102 COG2229
Signal recognition particle receptor subunit beta, a GTPase [Intracellular trafficking, ...
 7-178 1.77e-51

Signal recognition particle receptor subunit beta, a GTPase [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 441830 [Multi-domain]  Cd Length: 189  Bit Score: 163.07  E-value: 1.77e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349711   7 KLVFVGGMGAGKTTAVRAISDVEPVSTEMPLSQDAYGDKTYTTVALDYSSIELEDGELLHVYGVPGQKYLDFMWPLVCDG 86
Cdd:COG2229   14 KIVYAGPFGAGKTTFVRSISEIEPLSTEGRLTDASLETKTTTTVAFDFGRLTLGDGLRLHLFGTPGQVRFDFMWDILLRG 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349711  87 ALGVIVLTSARDTQMRDtTLELLREFSRITPEASLAVGVTMTDEVQEFLLPPFREALvAEGFRIPVMRVDARSATQITFL 166
Cdd:COG2229   94 ADGVVFLADSRRLEDSF-NAESLDFFEERLEKLPFVVAVNKRDLPDALSLEELREAL-DLGPDVPVVEADARDGESVKET 171

                        170
                 ....*....|..
gi 499349711 167 VKTLLSYRYTSA 178
Cdd:COG2229  172 LIALLELVLARL 183
ATP_bind_1 pfam03029
Conserved hypothetical ATP binding protein; Members of this family are found in a range of ...
 10-93 1.43e-06

Conserved hypothetical ATP binding protein; Members of this family are found in a range of archaea and eukaryotes and have hypothesized ATP binding activity.


Pssm-ID: 397252 [Multi-domain]  Cd Length: 238  Bit Score: 46.60  E-value: 1.43e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349711   10 FVGGMGAGKTTAVRAISDV-----------------------------EPVSTEMPLSQDAYGDKTYTTVALDYSSIELE 60
Cdd:pfam03029   1 VVGPAGSGKTTFVGALSEIlplrgrpvyvvnldpaaenlpypadidirELITVADVMEDYGLGPNGALTVAMDFGRITLD 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 499349711   61 --DGEL-----LHVYGVPGQKYLDFMWP--------LVCDGALGVIVL 93
Cdd:pfam03029  81 wlDEELkreddYYLFDTPGQIELFTHWDslaiiveaLESRGALGAVYL 128
Ras_like_GTPase cd00882
Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like ...
 9-172 1.21e-05

Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras, Rho, Rab, and Sar1/Arf families. This superfamily also includes proteins like the GTP translation factors, Era-like GTPases, and G-alpha chain of the heterotrimeric G proteins. Members of the Ras superfamily regulate a wide variety of cellular functions: the Ras family regulates gene expression, the Rho family regulates cytoskeletal reorganization and gene expression, the Rab and Sar1/Arf families regulate vesicle trafficking, and the Ran family regulates nucleocytoplasmic transport and microtubule organization. The GTP translation factor family regulates initiation, elongation, termination, and release in translation, and the Era-like GTPase family regulates cell division, sporulation, and DNA replication. Members of the Ras superfamily are identified by the GTP binding site, which is made up of five characteristic sequence motifs, and the switch I and switch II regions.


Pssm-ID: 206648 [Multi-domain]  Cd Length: 161  Bit Score: 43.21  E-value: 1.21e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349711   9 VFVGGMGAGKTTAVRAI--SDVEPVSTEMPlsqdaygdktyTTVALDYSSIELE-DGELLHVYGVPGQKYLDFMWP---- 81
Cdd:cd00882    1 VVVGRGGVGKSSLLNALlgGEVGEVSDVPG-----------TTRDPDVYVKELDkGKVKLVLVDTPGLDEFGGLGReela 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349711  82 -LVCDGALGVIVLTSARDTQMRDTTLELLREFSRITPEASLAVGvTMTDEVQEFLLPPFREALVAEGF-RIPVMRVDARS 159
Cdd:cd00882   70 rLLLRGADLILLVVDSTDRESEEDAKLLILRRLRKEGIPIILVG-NKIDLLEEREVEELLRLEELAKIlGVPVFEVSAKT 148

                        170
                 ....*....|...
gi 499349711 160 ATQITFLVKTLLS 172
Cdd:cd00882  149 GEGVDELFEKLIE 161
Gem1 COG1100
GTPase SAR1 family domain [General function prediction only];
7-171 7.95e-03

GTPase SAR1 family domain [General function prediction only];


Pssm-ID: 440717 [Multi-domain]  Cd Length: 177  Bit Score: 35.34  E-value: 7.95e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349711   7 KLVFVGGMGAGKTTAVRAisdvepvstempLSQDAYGDKTYTT---VALDYSSIELEDGEL-LHVYGVPGQ--------K 74
Cdd:COG1100    5 KIVVVGTGGVGKTSLVNR------------LVGDIFSLEKYLStngVTIDKKELKLDGLDVdLVIWDTPGQdefretrqF 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349711  75 YLDFMwplvcDGALGVIVLTSARDTQMRDTTLELLREFSRITPEASLAVGVTMTDEVQEFLLPP---FREALVAEGFRiP 151
Cdd:COG1100   73 YARQL-----TGASLYLFVVDGTREETLQSLYELLESLRRLGKKSPIILVLNKIDLYDEEEIEDeerLKEALSEDNIV-E 146

                        170       180
                 ....*....|....*....|
gi 499349711 152 VMRVDARSATQITFLVKTLL 171
Cdd:COG1100  147 VVATSAKTGEGVEELFAALA 166
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH