|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
13-473 |
1.62e-112 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 339.20 E-value: 1.62e-112
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 13 KIGYSLGDLAANLIFQTLVTFLAFFYTDVFRIPASAAATLIFVVGLLGAFvFTPIIGILADRTRTRWGKFRPWILWTALP 92
Cdd:cd17332 1 KIGYGLGDFGNNLIFQIVSTYLLFFYTDVLGLSAAAAGTIFLVARIIDAI-NDPLMGYLIDRTRSRWGRFRPWLLWGAIP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 93 FGALSLAAFNTPALGEHGKLIYAFATYTLLMLVYVANNLPYSALSGVLTGSMEQRNSLSAYRFLAVTFAQFIIQVLLLPL 172
Cdd:cd17332 80 LALLFVLLFTTPDGSGTGKLIYALITYILLDLLYTLVNIPYTALIPELTDDPEERTSLTSWRMFFATIGGLLVTVLPPPL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 173 VLILGNGDKAQGFRNTMALFAAIGTLCFLITFFTTRERVLPITEQRT--SVRQDLTDLIRNKPWLVMLALTILVFINLAM 250
Cdd:cd17332 160 VAYFGGGNASRGYFLTALIIGIIGIILLLICFFGTRERVVPPEEEKSklPLLKSLKALLKNRPFLILLLAYLLYFLAFNI 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 251 KGGMYIYYFKYYLdagalaqfldnagfnrfigainsvltgagmstlqWPQDAPTSAFSVFSAGGILAMIVGIGFSKRLad 330
Cdd:cd17332 240 VNTVLVYYFKYVL----------------------------------GGRAELVLLLLLILSGALLALLPWPPLKKRF-- 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 331 rnGKRNVFGGALLISTLFLLAFYVYSPTAIGWVFASYVLHGFFYGITIPLLWAMIADVADYSEWKNHRRATAIIFSAMLC 410
Cdd:cd17332 284 --GKKKAFFIGLLLAILGLLLLFFLPPGNLVLILVLAVLAGIGYGGANLLPWAMLADVIDYGELKTGKRREGIFYSVMTF 361
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 499349897 411 GLKIGLSVGGALVAGILAFYGYDAAIPQQSAAVTGGIRLAISVYASIPFLLGTALLALYEIDK 473
Cdd:cd17332 362 FRKLGLALAGALVGLILSLAGYVANAAAQSASALNGIRLLIAVLPAVLLLLALILMSFYPLDK 424
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
5-489 |
6.92e-112 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 338.42 E-value: 6.92e-112
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 5 SQQLSLREKIGYSLGDLAANLIFQTLVTFLAFFYTDVFRIPASAAATLIFVVGLLGAFVfTPIIGILADRTRTRWGKFRP 84
Cdd:COG2211 4 KKKLSLKEKLAYGLGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAIT-DPLIGALSDRTRTRWGRRRP 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 85 WILWTALPFGALSLAAFNTPALGEHGKLIYAFATYTLLMLVYVANNLPYSALSGVLTGSMEQRNSLSAYRFLAVTFAQFI 164
Cdd:COG2211 83 WILIGAIPLALSFVLLFTAPDLSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTPDYEERTRLSSWRFAFAGLGGLL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 165 IQVLLLPLVLILGnGDKAQGFRNTMALFAAIGTLCFLITFFTTRERVLPiTEQRTSVRQDLTDLIRNKPWLVMLALTILV 244
Cdd:COG2211 163 ASVLPPPLVAAFG-GDAALGYRLTALIFAVLGLLAFLLTFFGTKERPVP-EEEKVSLKESLKALLKNRPFLLLLLAYLLF 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 245 FINLAMKGGMYIYYFKYYLdagalaqfldnagfnrfigainsvltgagmstlqwpqDAPTSAFSVFSAGGILAMIVGIGF 324
Cdd:COG2211 241 FLALALVAALLLYYFKYVL-------------------------------------GLSAALVGLLLALYFLAALLGAPL 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 325 SKRLADRNGKRNVFGGALLISTLFLLAFYVYSPTAIGWVFASYVLHGFFYGITIPLLWAMIADVADYSEWKNHRRATAII 404
Cdd:COG2211 284 WPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKTGRRREGLY 363
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 405 FSAMLCGLKIGLSVGGALVAGILAFYGYDAAIPQQSAAVTgGIRLAISVYASIPFLLGTALLALYEIDKALETRIEHELG 484
Cdd:COG2211 364 FGIFTFAIKLGQALAGALAGLLLALFGYVAGAAQSPSALT-GIRLLFFLLPAVLLLLAALLLLFYPLTRERHAEIRAELA 442
|
....*
gi 499349897 485 TRRQA 489
Cdd:COG2211 443 ARRAA 447
|
|
| PRK09669 |
PRK09669 |
putative symporter YagG; Provisional |
5-484 |
1.13e-97 |
|
putative symporter YagG; Provisional
Pssm-ID: 236610 Cd Length: 444 Bit Score: 301.64 E-value: 1.13e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 5 SQQLSLREKIGYSLGDLAANLIFQTLVTFLAFFYTDVFRIPASAAATLIFVVGLLGAFVfTPIIGILADRTRTRWGKFRP 84
Cdd:PRK09669 3 TSQLTTKDKIGYGLGDTACNLVWQTVMLFLAYFYTDVFGLSAAIMGTMFLVVRVLDAVT-DPLMGALVDRTRTRHGQFRP 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 85 WILWTALPFGALSLAAFNTPALGEHGKLIYAFATYTLLMLVYVANNLPYSALSGVLTGSMEQRNSLSAYRFLAVTFAQFI 164
Cdd:PRK09669 82 YLLWFAIPFGVVCLLTFYTPDFGATGKIIYACVTYILLSLVYTAINVPYCAMPGAITNDPRERHSLQSWRFALSFIGGLI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 165 IQVLLLPLVLILGNGDKAQGFRNTMALFAAIGTLCFLITFFTTRERVLPITEQRTSVRQDLTDLIRNKPWLVMLALTILV 244
Cdd:PRK09669 162 VSVIALPLVDILGKGDEQKGYFYAMMVMGLLGVVLFFCCFFMTKERYTPEVDNSSSVWKDLKLLLGNSQWRIMFIFNVVL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 245 FINLAMKGGMYIYYFKYYLDAGALAqfldnagfnrfigainsvltgagmstlqwpqdaptsafSVFSAGGILAMIVGIGF 324
Cdd:PRK09669 242 LTAVVTRGGATLYYVNYVLLRPDLA--------------------------------------TLFLVTGMIAGLFGALL 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 325 SKRLADRNGKRNVFGGALLISTLFLLAFYVYSPTAIGWVFASYVLHGFFYGITIPLLWAMIADVADYSEWKNHRRATAII 404
Cdd:PRK09669 284 SERLLGKFDRVRAFKWTIVAFVILSALIFFIPPSNVWLIFALNILFNFIQNLTTPLQWSMFSDVVDYEEKRSGRRLDGLV 363
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 405 FSAMLCGLKIGLSVGGALVAGILAFYGYDAAIPQQSAAVTGGIRLAISVYASIPFLLGTALLALYEIDKALETRIEHELG 484
Cdd:PRK09669 364 FSTNLFAIKLGLAIGGAVVGWILAWVDYVGGAAVQSASVLTTINLLFTVIPGVLFAGMAIILNFYKLNDARVEAIAQELV 443
|
|
| gph |
TIGR00792 |
sugar (Glycoside-Pentoside-Hexuronide) transporter; The Glycoside-Pentoside-Hexuronide (GPH): ... |
13-486 |
5.46e-89 |
|
sugar (Glycoside-Pentoside-Hexuronide) transporter; The Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter Family (TC 2.A.2) GPH:cation symporters catalyze uptake of sugars in symport with a monovalent cation (H+ or Na+). Members of this family includes transporters for melibiose, lactose, raffinose, glucuronides, pentosides and isoprimeverose. Mutants of two groups of these symporters (the melibiose permeases of enteric bacteria, and the lactose permease of Streptococcus thermophilus) have been isolated in which altered cation specificity is observed or in which sugar transport is uncoupled from cation symport (i.e., uniport is catalyzed). The various members of the family can use Na+, H+ or Li, Na+ or Li+, H+ or Li+, or only H+ as the symported cation. All of these proteins possess twelve putative transmembrane a-helical spanners. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273270 Cd Length: 437 Bit Score: 279.14 E-value: 5.46e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 13 KIGYSLGDLAANLIFQTLVTFLAFFYTDVFRIPASAAATLIFVVGLLGAFvFTPIIGILADRTRTRWGKFRPWILWTALP 92
Cdd:TIGR00792 1 KLSYGFGDFGNDFIFAIVSTYLLFFYTDVLGLSAAFVGTLFLVARILDAI-TDPIMGNIVDRTRTRWGKFRPWLLIGAIP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 93 FGALSLAAFNTPALGEHGKLIYAFATYTLLMLVYVANNLPYSALSGVLTGSMEQRNSLSAYRFLAVTFAQFIIQVLLLPL 172
Cdd:TIGR00792 80 FSIVLVLLFTTPDFSGTGKLVYAYITYILLGLFYSFVNIPYWSLVPAITLDPRERESLSTFRRFGATLGGLLVAVIVLPL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 173 VLILGNGDKAQGFRNTMALFAAIGTLCFLITFFTTRERVLPIT---EQRTSVRQDLTDLIRNKPWLVMLALTILVFINLA 249
Cdd:TIGR00792 160 VSYFGGGDDKFGWFMFALVLALIGVVSLIICFFGTKERYSEIPkniEKKLSLKQIFKALFKNDQLLILCLAYLFYNLAFN 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 250 MKGGMYIYYFKYYLDAGALaqfldnagfnrfigainsvltgagmstlqwpqdaptsaFSVFSAGGILAMIVGIGFSKRLA 329
Cdd:TIGR00792 240 IKNGVQVYYFTYVLGDPEL--------------------------------------FSYMGSIAIVAGLIGVLLFPRLV 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 330 DRNGKRNVFGGALLISTLFLLAFYVySPTAIGWVFASYVLHGFFYGITIPLLWAMIADVADYSEWKNHRRATAIIFSAML 409
Cdd:TIGR00792 282 KKFGRKILFAGGILLMVLGYLIFFF-AGSNLPLILVLIILAGFGQNIVTGLVWALVADTVDYGEWKTGIRAEGLVYSVRT 360
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 499349897 410 CGLKIGLSVGGALVAGILAFYGYDAAIPQQSAAVTgGIRLAISVYASIPFLLGTALLA-LYEIDKALETRIEHELGTR 486
Cdd:TIGR00792 361 FVRKLGQALAGFFVGLILGIIGYVANAAQSPITLN-GIKILMFAVPALFLLLAAIIIGrFYKLTEKKHAEIVEELEQR 437
|
|
| PRK11462 |
PRK11462 |
putative transporter; Provisional |
4-469 |
1.09e-80 |
|
putative transporter; Provisional
Pssm-ID: 183145 Cd Length: 460 Bit Score: 258.33 E-value: 1.09e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 4 RSQQLSLREKIGYSLGDLAANLIFQTLVTFLAFFYTDVFRIPASAAATLIFVVGLLGAfVFTPIIGILADRTRTRWGKFR 83
Cdd:PRK11462 2 KSEVLSVKEKIGYGMGDAASHIIFDNVMLYMMFFYTDIFGIPAGFVGTMFLVARALDA-ISDPCMGLLADRTRSRWGKFR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 84 PWILWTALPFGALSLAAFNTPALGEHGKLIYAFATYTLLMLVYVANNLPYSALSGVLTGSMEQRNSLSAYRFLAVTFAQF 163
Cdd:PRK11462 81 PWVLFGALPFGIVCVLAYSTPDLSMNGKMIYAAITYTLLTLLYTVVNIPYCALGGVITNDPTQRISLQSWRFVLATAGGM 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 164 IIQVLLLPLVLILGNGDKAQGFRNTMALFAAIGTLCFLITFFTTRERVlPITEQRTSVRQDLTDLIRNKPWLVMLALTIL 243
Cdd:PRK11462 161 LSTVLMMPLVNLIGGDNKPLGFQGGIAVLSVVAFMMLAFCFFTTKERV-EAPPTTTSMREDLRDIWQNDQWRIVGLLTIF 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 244 VFINLAMKGGMYIYYFKYYLDAGALaqfldnagfnrfigainsvltgagmstlqwpqdaptsaFSVFSAGGILAMIVGIG 323
Cdd:PRK11462 240 NILAVCVRGGAMMYYVTWILGTPEV--------------------------------------FVAFLTTYCVGNLIGSA 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 324 FSKRLADRNGKRNVFGGALLISTLFLLAFYVYSPTAIGWVFASYVLHGFFYGITIPLLWAMIADVADYSEWKNHRRATAI 403
Cdd:PRK11462 282 LAKPLTDWKCKVTIFWWTNALLAVISLAMFFVPMQASITMFVFIFVIGVLHQLVTPIQWVMMSDTVDYGEWCNGKRLTGI 361
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 499349897 404 IFSAMLCGLKIGLSVGGALVAGILAFYGYDAAIPQQSAAVTGGIRLAISVYASIPFLLGTALLALY 469
Cdd:PRK11462 362 SFAGTLFVLKLGLAFGGALIGWMLAYGGYDAAEKAQNSATISIIIALFTIVPAICYLLSAIIAKRY 427
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
15-473 |
1.08e-69 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 228.73 E-value: 1.08e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 15 GYSLGDLAANLIFQTLVTFLAFFYTDVFRIPASAAATLIFVVGLLGAFvFTPIIGILADRTRTRWGKFRPWILWTALPFG 94
Cdd:pfam13347 1 GYGSGALAAGIKYAGLATYLLYFYTDVLGLSAAAVGLVLLVARLVDAF-TDPIVGHIIDRTRTRWGRRRPWLLLSAIILA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 95 ALSLAAFNTPALGEHGKLIYAFATYTLLMLVYVANNLPYSALSGVLTGSMEQRNSLSAYRFLAVTFAQFIIQVLLLP-LV 173
Cdd:pfam13347 80 VSFILLFTPPELGRAPLFIWLLATYILLRIAYTFFEIPYWSLGPELTRDYDERTSLTSYRSFFSVGGGLLAAALAFPlVL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 174 LILGNGDKAQGFRNTMALFAAIGTLCFLITFFTTRERVLPITE------QRTSVRQDLTDLIRNKPWLVMLALTILVFIN 247
Cdd:pfam13347 160 ILGGTGLERKGYRIFALIGAVLMLLGVIITAAGTKERVSMRSKedtgqkEAGSLLDMLKEVFRNRAFLILLASFLLAALA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 248 LAMKGGMYIYYFKYYLDAGalaqfldnagfnrfigainsvltgagmstlqwpqdaptSAFSVFSAGGILAMIVGIGFSKR 327
Cdd:pfam13347 240 MGVLNGLLLYYFRYVLGNG--------------------------------------FAASAFPLVFTIGALLGIPLWPP 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 328 LADRNGKRNVFGGALLISTLFLLAFYVYSPTAIGWVFASYVLHGFFYGITIPLLWAMIADVADYSEWKNHRRATAIIFSA 407
Cdd:pfam13347 282 LAKRIGKKNTYILGALITIAGFALALLLGPNNTLLFLVLYIIIGFGYGSSFFLPWSMLADVVDYGELRTGKRREGTFFAM 361
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 499349897 408 MLCGLKIGLSVGGALVAGILAFYGYDAAIPQQSAAVTGGIRLAISVYASIPFLLGTALLALYEIDK 473
Cdd:pfam13347 362 WSFISKLATGVGLGVSGLLLSAFGYNAGDSVQSPQAVTAIRLLYAVLPAVLFLVALLLLYFYPLDR 427
|
|
| PRK09848 |
PRK09848 |
glucuronide transporter; Provisional |
5-490 |
5.57e-58 |
|
glucuronide transporter; Provisional
Pssm-ID: 182109 [Multi-domain] Cd Length: 448 Bit Score: 198.47 E-value: 5.57e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 5 SQQLSLREKIGYSLGDLAANLIFQTLVTFLAFFYTDVFRIPASAAATLIFVVGLLGAFVfTPIIGILADRTRTRWGKFRP 84
Cdd:PRK09848 2 NQQLSWRTIVGYSLGDVANNFAFAMGALFLLSYYTDVAGVGAAAAGTMLLLVRVFDAFA-DVFAGRVVDSVNTRWGKFRP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 85 WILWTALPFGALSLAAFNTPA-LGEHGKLIYAFATYTLLMLVYVANNLPYSALSGVLTGSMEQRNSLSAYRFLAVTFAQF 163
Cdd:PRK09848 81 FLLFGTAPLMIFSVLVFWVPTdWSHSSKVVYAYLTYMGLGLCYSLVNIPYGSLATAMTQQPQSRARLGAARGIAASLTFV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 164 IIQVLLLPLVLILGNGDKAQGFRNTMALFAAIGTLCFLITFFTTRERVLPITEQrTSVRQDLTDLIRNKPWLVMLALTIL 243
Cdd:PRK09848 161 CLAFLIGPSIKNSSPEEMVSVYHFWTIVLAIAGMVLYFICFKSTRENVVRIVAQ-PSLKISLQTLKRNRPLFMLCIGALC 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 244 VFINLAMKGGMYIYYFKYYLDagalaqflDNAGFNRFIGAINSVLTgagmstlqwpqdaptsafsvFSAGGILAMIVGig 323
Cdd:PRK09848 240 VLISTFAVSASSLFYVRYVLN--------DTGLFTVLVLVQNLVGT--------------------VASAPLVPGMVA-- 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 324 fskrladRNGKRNVFGGALLISTLFLLAFYVYSPTAIGWVFASYVLHGFFYGITIPLLWAMIADVADYSEWKNHRRATAI 403
Cdd:PRK09848 290 -------RIGKKNTFLIGALLGTCGYLLFFWVSVWSLPVALVALAIASIGQGVTMTVMWALEADTVEYGEYLTGVRIEGL 362
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 404 IFSAMLCGLKIGLSVGGALVAGILAFYGYDAAiPQQSAAVTGGIRLAISVYASIPFLLGTALLALYEIDKALETRIEHEL 483
Cdd:PRK09848 363 TYSLFSFTRKCGQAIGGSIPAFILGLSGYIAN-QVQTPEVIMGIRTSIALVPCGFMLLAFVIIWFYPLTDKKFKEIVVEI 441
|
....*..
gi 499349897 484 GTRRQAA 490
Cdd:PRK09848 442 DNRKKVQ 448
|
|
| PRK10429 |
PRK10429 |
melibiose:sodium transporter MelB; |
8-491 |
1.47e-36 |
|
melibiose:sodium transporter MelB;
Pssm-ID: 182453 Cd Length: 473 Bit Score: 141.00 E-value: 1.47e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 8 LSLREKIGYSLGDLAANLIFQTLVTFLAFFYTDVFRIPASAAATLIFVVGLLGAfVFTPIIGILADRTRTRWGKFRPWIL 87
Cdd:PRK10429 3 ISMTTKLSYGFGAFGKDFAIGIVYMYLMYYYTDVVGLSVGLVGTLFLVARIWDA-INDPIMGWIVNNTRSRWGKFKPWIL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 88 WTALPFGALSLAAFNTPALGEHGKLIYAFATYTLLMLVYVANNLPYSALSGVLTGSMEQRNSLSAY-RFLAvTFAQFIIQ 166
Cdd:PRK10429 82 IGTLANSVVLFLLFSAHLFEGTAQYVFVCVTYILWGMTYTIMDIPFWSLVPTLTLDKREREQLVPYpRFFA-SLAGFVTA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 167 VLLLPLVLILGNGDKAQGFRNtmalFAAIGTLCFLITFFTTRERV---------LPITEQRTSVRQDLTDLIRNKPWLVM 237
Cdd:PRK10429 161 GFTLPFVNYVGGGDRGFGFQM----FTLVLIAFFIVSTIITLRNVhevyssdnqVSAEGSHLTLKDIVALIYKNDQLSCL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 238 LAlTILVFiNLAMK--GGMYIYYFKYYLDAGALaqfldnagfnrfigainsvltgagmstlqwpqdaptsaFSVFSAGGI 315
Cdd:PRK10429 237 LG-MALAY-NIASNiiNGFAIYYFTYVIGDADL--------------------------------------FPYYLSYAG 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 316 LAMIVGIGFSKRLADRNGKRNVFGGA---LLISTLFLLAFYVYSPTAIGWVFASYVLHGFFYGITIPLLWAMIADVADYS 392
Cdd:PRK10429 277 AANLVTLILFPRLVKSLSRRILWAGAsifPVLSCGVLLLMGLAAPHNALLIVIAGILLNIGTALFWVLQVIMVADTVDYG 356
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 393 EWKNHRRATAIIFSAMLCGLKIGLSVGGALVAGILAFYGYDAAIpQQSAAVTGGIRLaISVYASIPFLLGTALL--ALYE 470
Cdd:PRK10429 357 EYKLGIRCESIAYSVQTMVVKGGSAFAAFFIGVVLGLIGYVPNV-EQSAQTLLGMQF-IMIGLPTLFFMITLVLyfRYYR 434
|
490 500
....*....|....*....|.
gi 499349897 471 IDKALETRIEHELGTRRQAAP 491
Cdd:PRK10429 435 LNGDFLRRIQIHLLDKYRKVP 455
|
|
| MFS_MFSD2B |
cd17452 |
Major facilitator superfamily domain-containing protein 2B; Major facilitator superfamily ... |
13-473 |
1.95e-10 |
|
Major facilitator superfamily domain-containing protein 2B; Major facilitator superfamily domain-containing protein 2B (MFSD2B) is closely related to MFSD2A, and their conserved genomic structure suggests that they are derived from the duplication of an ancestral gene. Variations of chromosome 2 gene expressions among patients with lung cancer or non-cancer identified MFSD2B as a potential risk or protect factor in the prognosis of lung adenocarcinoma. MFSD2B belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341010 Cd Length: 416 Bit Score: 62.53 E-value: 1.95e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 13 KIGYSLGDLAANLIFQTLVTFLAFFYTDVFRIPASAAATLIFVVGLLGAfVFTPIIGILADRTR-TRWGKFRPWILwTAL 91
Cdd:cd17452 1 KLCYAIGGAPNQVAGSATAFFLQIYLLDIAQITPFQASLVLFVGKAWGA-ATDPVVGFFISKSKwTKIGRLMPWML-GCT 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 92 PFGALS-LAAFNTPALgEHGKLIYAFATYTLLMLVYVANNLPYSALSGVLTGSMEQRNSLSAYRFLAVTFAQFIiqvlll 170
Cdd:cd17452 79 PFIVVSyFFLWFVPPF-TTGRFLWYLTFYCLFQALATCFHVPYSALTMFLSTDQRERDSATAYRMTVEVLGTLV------ 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 171 plvlilgnGDKAQGFRNTMALFAAIGT------LCFLITFFTTRER---VLPITEQRTSVRQDLTDLIRNKPWLVMLALT 241
Cdd:cd17452 152 --------GAAVQGQIVASAYMIAAGVigglylLCISVLFLGVKERddpYAPKSGKAIPFFKGLSLTMRHGPYLKLTASF 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 242 ILVFINLAMKGGMYIYYFKYYLDAGALAQFLdnagfnrfigainsVLTgagmstlqwpqdaptsafsvfsagGILAMIVG 321
Cdd:cd17452 224 LFISAAVQLEQSNFVLFCTHAVDLHDHFQNL--------------VLT------------------------ILVSAVVS 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 322 IGFSKRLADRNGKRNV-FGGALLISTLFLLAFYVYSPTAIGWVFASyvlhGFFYGITIPLLWAMIADVADYSEWKNHRRA 400
Cdd:cd17452 266 IPFWQWFLQRFGKKAAaCGISWMIPFAIMLVTIPNLIVAYVVAFVS----GLSIAASLLLPWSMLPDVVDDFRLQNPHGK 341
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 499349897 401 --TAIIFSAMLCGLKIGLSVGGALVAGILAFYGYDAAIPQQSAAVTGGIRLAISVYASIPFLLGTALLALYEIDK 473
Cdd:cd17452 342 glETIFYSSYVFFTKLSAGIALGISTLSLEFAGYETGACKQPESVVLTLKLLIGAAPTCMILIGLCILMFYPITE 416
|
|
| MFS_MFSD2 |
cd17392 |
Major facilitator superfamily domain-containing protein 2 subfamily; The major facilitator ... |
13-473 |
1.11e-09 |
|
Major facilitator superfamily domain-containing protein 2 subfamily; The major facilitator superfamily domain-containing protein 2 (MFSD2) subfamily is composed of two vertebrate members, MFSD2A amd MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. The MFSD2 subfamily belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340950 Cd Length: 446 Bit Score: 60.56 E-value: 1.11e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 13 KIGYSLGDLAANLIFQTLVTFLAFFYTDVFRIPAsAAATLIFVVGLLGAFVFTPIIGILADRT-RTRWGKFRPWILWTaL 91
Cdd:cd17392 1 KLCYAIGGAPYQMTSSATGFFLQIFLLDVAQMGA-FSVSLILFVGRVWDAVTDPLVGYFISRSqRTGIGRLMPWIVFS-T 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 92 PFGALSLAAFNTPALGEHGKLIYAFATYTLLMLVYVANNLPYSALSGVLTGSMEQRNSLSAYR--------FLAVTFAQF 163
Cdd:cd17392 79 PLIILAYFFLWFLPPFTSLSGLWYLTFYCLFETFMTCFHVPYSALTMFLGGCQRERDSATAYRmtvevfgtLMGATIQGQ 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 164 IIQVLLLPLVLILGNGDKAQGF-----RNTMALF----AAIGTL---CFLITFFTTRERVLPI-TEQRTSVR--QDLTDL 228
Cdd:cd17392 159 IVGVAHRPRRQDCTATPGTSDHpvtvlPNTRRAYliaaLVVVVLyfvCCSILFLGVKEQPDPLsPASGPGLSylAGLKLV 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 229 IRNKPWLVMlaLTILVFINLA--MKGGMYIYYFKYYLDAGalaqfldnagfNRFIGAINSVLTGAGMSTLQWpqdaptsa 306
Cdd:cd17392 239 TGHPPYLKL--VIGFLFSSLAfqMEQGNFVLFCTHAAGLG-----------DHFQHLVLAILVSATLSIPLW-------- 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 307 fsvfsaggilAMIvgigfskrLADRNGKRNVFGG-ALLISTLFLLAFyVYSPTAIGWVFAsyVLHGFFYGITIPLLWAMI 385
Cdd:cd17392 298 ----------QWV--------LQRRGKKTTSFIGiSAMVPFLILLAL-VPSNLPVAYVVA--VVSGVSLAALFLLPWSML 356
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 386 ADVADYSEWKN-HRRATAIIFSAMLCGLKiglSVGGALVAGI----LAFYGYDAAIPQQSAAVTGGIRLAISVYASIPFL 460
Cdd:cd17392 357 PDVVDDFQLKNpHCPGLEPIFYSCYVFFT---KLGGGLSLGIstlsLHFSGYKAGACKQPEEVVVTLKVLIAPVPICLIL 433
|
490
....*....|...
gi 499349897 461 LGTALLALYEIDK 473
Cdd:cd17392 434 AGLVLFYVYPINE 446
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
47-390 |
3.98e-09 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 58.41 E-value: 3.98e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 47 SAAATLIFVVGLLGAFVFTPIIGILADRTRTRWGKFRPWILwTALPFGALSLAAF-NTPALGEH---GKLIYAFATYTLL 122
Cdd:cd17313 33 HALIGFVWTLGPILGLFVQPLVGSLSDRCNSRIGRRRPFIL-VGAPLAALGLILIpNAADIGLAlgdGPRTWALVLFVLG 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 123 M-LVYVANNL---PYSALSGVLTGSMEQRNSLSAYRFLA---VTFAQFIIQVLLLPLVLILGNGDKAQGFrntMALFAAI 195
Cdd:cd17313 112 IvLLDFAMNVcqgPVRALLPDLVPPEQRSKANGIINFMGglgGVLGYLLGAILWDHNWFGFALGGNLKVP---FYIGAII 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 196 GTLCFLITFFTTRERVLPITEQRTSVRQ-------DLTDLIRNKPW-LVMLALTIL-VFINlamkggmYIYYFKYYLDAG 266
Cdd:cd17313 189 LLVCVLVTLFFVKEPPLSPEAGEHSENPslgevlkSLLKLLKIMPRsLLRLLLVIFfWWIA-------FFPFELFFTDYM 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 267 ALAQFLDNAGFNRFIGAinSVLTGAGMSTLQwpqdapTSAFSVFSAggilamivgigFSKRLADRNGKRNVFGGALLIST 346
Cdd:cd17313 262 GEEVYHGTSAASSHYGA--GVRMGAWGLLIF------SLAFLIFSL-----------PIGKLGKKIGRKKVYLIGLVLFA 322
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 499349897 347 L-FLLAFYVYSPTAIGWVFASYvlhGFFYGITIPLLWAMIADVAD 390
Cdd:cd17313 323 VgMALMALVHNVTVALVLFALG---GIGWATININPYPLVSDYHS 364
|
|
| MFS_NLS1_MFSD2A |
cd17451 |
Sodium-dependent lysophosphatidylcholine symporter 1 of the Major Facilitator Superfamily of ... |
13-473 |
6.04e-07 |
|
Sodium-dependent lysophosphatidylcholine symporter 1 of the Major Facilitator Superfamily of transporters; Sodium-dependent lysophosphatidylcholine (LPC) symporter 1 (NLS1) is also called major facilitator superfamily domain-containing protein 2A (MFSD2A). NLS1/MFSD2A is an LPC symporter that plays an essential role for blood-brain barrier formation and function. It also transports the essential omega-3 fatty acid docosahexaenoic acid (DHA), which is essential for normal brain growth and cognitive function, in the form of LPC into the brain across the blood-brain barrier. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. NLS1/MFSD2A belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341009 Cd Length: 419 Bit Score: 51.74 E-value: 6.04e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 13 KIGYSLGDLAANLIFQTLVTFLAFFYTDVFRIPASAAATLIFVvGLLGAFVFTPIIGILADRTR-TRWGKFRPWILWTAl 91
Cdd:cd17451 1 KLCYAIGGAPYQITGCALGFFLQIYLLDVAQLDPFYASIILFV-GRAWDAITDPTVGFFVSKSPwTRFGRLMPWIIFST- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 92 PFGALSLAAFNTPALGEHGKLIYAFATYTLLMLVYVANNLPYSALSGVLTGSMEQRNSLSAYRFLAVTFAQFIiqvlllp 171
Cdd:cd17451 79 PFAVLSYFLIWFVPDFSQGKVMWYLLFYCLFQTLQTCFHVPYSALTMFISTEQKERDSATAYRMTVEVLGTVL------- 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 172 LVLILGNGDKAQGFRNTMALFAAIGTLCFLITFFTTRERVLP---ITEQRTSVRQDLTDLIRNKPWLVMLALTILVFINL 248
Cdd:cd17451 152 GTAIQGQIVGMAAYMIAAGVICAIYVLCAIILFLGVREQREPcelKSQKPVSFFKGLKLVMSHGPYIKLITGFLFTSLAF 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 249 AMKGGMYIYYFKYYLdagalaqfldnaGFNRFIGAINSVLtgagmstlqwpqdaptsafsvfsaggILAMIVGIGFSKRL 328
Cdd:cd17451 232 MLLEGNFALFCTYTL------------GFRNDFQNILLVI--------------------------MLSATLTIPFWQWF 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 329 ADRNGKRN-VFGGALLISTLFLLAFYVYSPTAIGWVFAsyVLHGFFYGITIPLLWAMIADVADYSEWKN--HRRATAIIF 405
Cdd:cd17451 274 LTRFGKKTaVYIGISSAVPFLILVVLVESNLIVTYVVS--VAAGVSVAAAFLLPWSMLPDVVDDFKLKNpdSQGHEAIFY 351
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 499349897 406 SAMLCGLKIGLSVGGALVAGILAFYGYDAAIPQQSAAVTGGIRLAISVYASIPFLLGTALLALYEIDK 473
Cdd:cd17451 352 SFYVFFTKFASGVSLGISTLSLDFAGYQTRGCSQPEEVNLTLKMLVSAAPVVLILLGLLLFKLYPIDE 419
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
280-424 |
3.74e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 45.74 E-value: 3.74e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 280 FIGAINSVLTGAGMSTLQWPQDAPTSAFSVFSAGGILAMIVGIGFSKRLADRNGKRNVFGGALLISTLFLLAFYVYspTA 359
Cdd:COG2814 20 FLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALA--PS 97
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 499349897 360 IGWVFASYVLHGFFYGITIPLLWAMIADVADYsewKNHRRATAIIFSAMLCGLKIGLSVGGALVA 424
Cdd:COG2814 98 LWLLLAARFLQGLGAGALFPAALALIADLVPP---ERRGRALGLLGAGLGLGPALGPLLGGLLAD 159
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
48-389 |
6.24e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 44.96 E-value: 6.24e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 48 AAATLIFVVGLLGAFVFTPIIGILADRtrtrWGKfRPWILWTALPFGALSLAAFNTPalgehgkliyafaTYTLLMLVYV 127
Cdd:COG2814 45 AQAGLVVTAYLLGAALGAPLAGRLADR----FGR-RRVLLLGLLLFALGSLLCALAP-------------SLWLLLAARF 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 128 ANNLPYSALSGVLTGSM------EQRNSLSAYRFLAVTFAQFIIQVLLLPLVLILGngdkaqgFRNTMALFAAIGTLCFL 201
Cdd:COG2814 107 LQGLGAGALFPAALALIadlvppERRGRALGLLGAGLGLGPALGPLLGGLLADLFG-------WRWVFLVNAVLALLALL 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 202 ITFFTTRErvlPITEQRTSVRQDLTDLIRNKPWLVMLALTILVFInlamkggmyiyyfkyyldagalaqfldnagfnrFI 281
Cdd:COG2814 180 LLLRLLPE---SRPAARARLRGSLRELLRRPRLLLLLLLAFLLGF---------------------------------GF 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 282 GAINSVLTGAGMSTLQWPQDAPTSAFSVFSAGGILAMIVGIgfskRLADRNGKRNVFGGALLISTLFLLAFYVysPTAIG 361
Cdd:COG2814 224 FALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAG----RLADRFGRRRLLLIGLLLLALGLLLLAL--AGSLW 297
|
330 340
....*....|....*....|....*...
gi 499349897 362 WVFASYVLHGFFYGITIPLLWAMIADVA 389
Cdd:COG2814 298 LLLLALFLLGFGFGLLFPLLQALVAELA 325
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
293-436 |
1.24e-04 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 44.09 E-value: 1.24e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 293 MSTLQWPQDAPTSAFSVFSAGGILAMIVGIGFSKRLADRNgkRNVFGGALLISTLFLLAFYVYSPTAigWVFASYVLHGF 372
Cdd:COG2271 208 VEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRR--KLVLAIGLLLAALALLLLALLPSPA--LAIALLFLAGF 283
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 499349897 373 FYGITIPLLWAMIADVAdysewknHRRATAIIFSAMLCGLKIGLSVGGALVAGILAFYGYDAAI 436
Cdd:COG2271 284 GLGGAFGLLWALAAELF-------PKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAF 340
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
26-428 |
2.84e-04 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 42.93 E-value: 2.84e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 26 IFQTLVTFLAFFYTDVFRIPASAAATLIFVVGLLGAFvFTPIIGILADRTRtrwgkfRPWILWTALPFGALSLAafntpa 105
Cdd:cd17478 10 FYQGFLPALLPLLIAKLGLSYAQAGLLVSVFSITSSL-LQPLFGYLADRKP------RRYLLPLGPLLTGLGLS------ 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 106 lgehgkLIYAFATYTLLMLVYVANNLPYSA---LSGVLTG--SMEQRNSLSAYRFLAVTFAQFIIQVLLLPLVLILGNGD 180
Cdd:cd17478 77 ------LLGFAPNYWLLLLLVALAGIGSAAfhpEGARLASqaAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLG 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 181 kaqgfrntMALFAAIGTLCFLITFFTTRERVLPITEQRTSVRQdlTDLIRNKPWLVMLALTILVFINLAMKGGMYIYYFK 260
Cdd:cd17478 151 --------LLILLIIPGLAVALLLLRLRPLKKPEAKKAAAKSS--ARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPF 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 261 YYLDAGalaqfldnaGFNRFIGAINSVLTGAGmstlqwpqdaptsafsvfSAGGILAmivgigfsKRLADRNGKRNVFGG 340
Cdd:cd17478 221 YLVQRG---------YSLVFAGLLLSLFLFAG------------------AIGTLIG--------GPLSDRFGRRRVIIA 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 341 ALLISTLFLLAFYVYSPTaigWVFASYVLHGFFYGITIPLLWAMIADVAdysewknHRRATAIifSAMLCGLKIGLSVGG 420
Cdd:cd17478 266 SLLLAAPFLLLFLLTPGI---WSYILLVLAGFLLFASFPVTVVLAQELL-------PGNVGLA--SGLMMGLSFGLGGIG 333
|
....*...
gi 499349897 421 ALVAGILA 428
Cdd:cd17478 334 APVLGALA 341
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
309-435 |
7.02e-04 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 41.87 E-value: 7.02e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 309 VFSAGgILAMIVGIGFSKRLADRNGKRNVFGGALLISTLFLLAfyvyspTAIGWVFASYVLHGFFYGI----TIPLLWAM 384
Cdd:PRK11551 55 AFSAG-ILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLA------TAQAWDFPSLLVARLLTGVglggALPNLIAL 127
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 499349897 385 IADVADysewkNHRRATAIifSAMLCGLKIglsvGGALVAGILAFYGYDAA 435
Cdd:PRK11551 128 TSEAVG-----PRLRGTAV--SLMYCGVPF----GGALASVIGVLAAGDAA 167
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
290-423 |
7.49e-04 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 41.79 E-value: 7.49e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 290 GAGMSTLQWpqdaptsAFSVFsaggILAMIVGIGFSKRLADRNGKRNVFGGALLISTLFLLAFYVySPTAIGWVFASyVL 369
Cdd:cd17503 27 GASLDTVQW-------VITSY----LLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL-APNLASLIIFR-IL 93
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 499349897 370 HGFFYGITIPLLWAMIADVADYSEwknHRRATAIIFSAMLCGLKIGLSVGGALV 423
Cdd:cd17503 94 QGFGGGVLIPLAQTILLRIYPPEK---RGAAMGLVGLVILLAPAIGPTLGGWLT 144
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
303-432 |
1.03e-03 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 41.57 E-value: 1.03e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 303 PTSAFSVFSAGgILAMIVGIGFSKRLADRNGKRNVFGGALLISTLFLLAfyvyspTAIGWVFASYVLHGFFYGITI-PLL 381
Cdd:TIGR00895 51 PVQLGFLFSAG-LIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLL------CALATNVTQLLILRFLAGLGLgGLM 123
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 499349897 382 WAMIADVADYSEWKnhRRATAIifSAMLCGLKIGLSVGGALVAGILAFYGY 432
Cdd:TIGR00895 124 PNLNALVSEYAPKR--FRGTAV--GLMFCGYPIGAAVGGFLAGWLIPVFGW 170
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
306-424 |
1.36e-03 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 41.02 E-value: 1.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 306 AFSVFSAGGILAMIvgigFSKRLADRNGKRNVFGGALLISTLFLLAFyVYSPTaIGWVFASYVLHGFFYGITIPLLWAMI 385
Cdd:cd17325 36 IVAAYALAQLLFSP----PAGRLSDRFGRKRLLLLGLLLLAVSTLLF-AFATS-YWQLLLARFLQGLASAAVWPAAMALI 109
|
90 100 110
....*....|....*....|....*....|....*....
gi 499349897 386 ADVADYSEWknhRRATAIIFSAMLCGLKIGLSVGGALVA 424
Cdd:cd17325 110 ADIAPPEER---GRAMGIFSSAIGLGFLIGPLLGGLLAD 145
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
21-126 |
1.64e-03 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 40.59 E-value: 1.64e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 21 LAANLIFQTLVTFLAFFYTDVFRIPASAAaTLIFVVGLLGAFVFTPIIGILADrtrtRWGKfRPWILWTALPFGALSLAA 100
Cdd:cd17369 238 LAENVLFYLFTTFALSYATQTLGVDRSTV-LLAVLIASVVAAITIPLFGWLSD----RVGR-RPVYLAGALLAALFAFPF 311
|
90 100
....*....|....*....|....*.
gi 499349897 101 FntPALGEHGKLIYAFATYTLLMLVY 126
Cdd:cd17369 312 F--WLLDTGSTWLIVLAAVVVLGVLH 335
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
23-386 |
2.56e-03 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 40.14 E-value: 2.56e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 23 ANLIFQTLVT--FLAFFYTDVFRIPASAAATLIF-----VVGLLGAfVFTPIIGILADRTRTRwgkfRPWILWTALpFGA 95
Cdd:COG2270 21 ANSAFSTVITtfVFPPYFTSVAALGDPAAATALWgyalaIAGLLVA-LLAPVLGAIADRSGRK----KPFLAFFTL-LGV 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 96 LSLAAFNTPALGehgkliyafaTYTLLMLVYVANNLPYSAlSGVLTGSM-------EQRNSLSAYRFlAV----TFAQFI 164
Cdd:COG2270 95 LATAALFFVAPG----------GLWLGLLLFVLANIGFEG-SLVFYNAFlpdiatpEEIGRVSGLGW-ALgylgGVLLLL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 165 IQVLLLPLVLILGNGDKAQGFRNTMALFAAIGTLCFLITFFTTRERVLPITE-QRTSVRQDLTDLIRnkpwlvmlaltil 243
Cdd:COG2270 163 INLALFLKPEAFGLPDAGEAVRISFLLTALWWLLFALPLFLFLPERPRPGPApPRGAVRAGFRELRR------------- 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 244 VFINLAMKGGMyiyyfKYYLdagaLAQFLDNAGfnrfIGAINSVLTGAGMSTLQWpqdaPTSAFSVFsagGILAMIVGIG 323
Cdd:COG2270 230 TLRELRRYRDL-----LRFL----LAYFFYRDG----VQTVIAFAGIYAAGVLGF----STTELIVF---GLLVQIVAAL 289
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 499349897 324 FS---KRLADRNGKRNVFGGALLISTLFLLAFYVYSPTAIGWVFAsyVLHGFFYGITIPLLWAMIA 386
Cdd:COG2270 290 GAllfGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTTALAFWILG--LLIGLVMGGIQALSRSLLA 353
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
316-435 |
4.76e-03 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 39.13 E-value: 4.76e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 316 LAMIVGIGFSKRLADRNGKRNVFGGALLISTLFLLAFYVYSptAIGWVFASYVLHGFFYGITIPLLWAMIADVADYSewk 395
Cdd:cd17329 46 VAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAH--SPWLFAIALVLTGFGGGLFEPASEAMIADVTTPE--- 120
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 499349897 396 NHRRATAIIFSAMLCGLKIglsvgGALVAGILAFYGYDAA 435
Cdd:cd17329 121 NRTRAFSLLYWAINLGVAI-----GPLLGGLLLLYSFRLL 155
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
309-468 |
5.84e-03 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 38.72 E-value: 5.84e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 309 VFSAGgILAMIVGIGFSKRLADRNGKRNVFGGALLISTLFLLAfyvyspTAIGWVFASYVLHGFFYGITI-PLLWAMIAD 387
Cdd:cd17365 39 VGSAA-LFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLL------TAFAQSVLQLALLRFLTGLGLgAAMPNAITL 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 388 VADYSEWKnhRRATAIifSAMLCGLKIGLSVGGALVAGILAFYGYdaaipqQSAAVTGGIRLAISVyasiPFLLGTALLA 467
Cdd:cd17365 112 VSEYAPAR--RRSLAV--TLMFCGYPLGAALGGFLAAALIPAFGW------RSVFLLGGVPPLILL----PLLRGTLLLW 177
|
.
gi 499349897 468 L 468
Cdd:cd17365 178 V 178
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
305-424 |
6.17e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 38.94 E-value: 6.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 305 SAFSVFSAGGILAMIVGIGFSKRLADRNGKRNVFGGALLISTLFLLAFYVYSPtaIGWVFASYVLHGFFYGITIPLLWAM 384
Cdd:pfam07690 32 TEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASS--LWLLLVLRVLQGLGAGALFPAALAL 109
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 499349897 385 IADVADYSEWKnhrRATAIIFSAMLCGLKIGLSVGGALVA 424
Cdd:pfam07690 110 IADWFPPEERG---RALGLVSAGFGLGAALGPLLGGLLAS 146
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
14-426 |
7.57e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 38.75 E-value: 7.57e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 14 IGYSLGDLAANLIFQTLVTFLAFFYTDvfripaSAAATLIFVVGLLGAFVFTPIIGILADRTRTRWgkfrpWILWTALPF 93
Cdd:cd06173 6 LAQLLSALGDWIFTVALPWLVLQLTGS------ALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRR-----LLILADLLR 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 94 GALSLAAfntpALGEHGKLIYAFATYTLLMLVYVANNLPYSALSGVLTG--SMEQRNSLSAYRFLAVTFAQFIIQVLLLP 171
Cdd:cd06173 75 ALLAAVL----ALLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPElvPKEQLVRANALNSLATQLARIIGPALGGL 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 172 LVLILGNGdkaQGFRNTMALFAAIGTLCFLITFFTTRERVLPITEQRTSVRQDLTDLIRNKPWLVMLALTILVFINLAMK 251
Cdd:cd06173 151 LVALLGPG---GAFAINALSFLLSALLLLFIRRPPPAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGAL 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 252 GGMYIYYFKYYLDAGAlaqfldnagfnrfigainsvltgagmstlqwpqdaptSAFSVFSAGGILAMIVGIGFSKRLADR 331
Cdd:cd06173 228 TVLLPLLAKEVLGGGA-------------------------------------AGYGLLLAAFGVGALLGALLLGRLSKR 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 332 NGKRNVFGGALLISTLFLLAFYVysPTAIGWVFASYVLHGFFYGITIPLLWAMIADVADysewKNHR-RATAIIFSAMLC 410
Cdd:cd06173 271 RRRGRLLLIGALLLGLALLVLGL--SPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVP----DELRgRVFSVYNALNSG 344
|
410
....*....|....*.
gi 499349897 411 GLKIGLSVGGALVAGI 426
Cdd:cd06173 345 AMPLGALLAGLLADAL 360
|
|
| MFS_MFSD12 |
cd17491 |
Major facilitator superfamily domain-containing protein 12; Major facilitator superfamily ... |
13-88 |
8.22e-03 |
|
Major facilitator superfamily domain-containing protein 12; Major facilitator superfamily domain-containing protein 12 (MFSD12) protein subfamily includes a group of uncharacterized proteins similar to human MFSD2. MFSD2 is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is an LPC symporter that plays an essential role for blood-brain barrier formation and function. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. The MFSD12 subfamily belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341044 Cd Length: 438 Bit Score: 38.78 E-value: 8.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499349897 13 KIGYSLG----DLAANLIFqtlvTFLAFFYTDVFRIPASAAATLIFVVGLLGAfVFTPIIGILADRTRTRW--GKFRPWI 86
Cdd:cd17491 1 RIAYGVGhvlnDLCASMWF----TYLLVYFHLVLGFSSALAGILLLIGQVADA-ISTPLVGYESDRTNGCGkyGRRKSWH 75
|
..
gi 499349897 87 LW 88
Cdd:cd17491 76 LI 77
|
|
| |
