|
Name |
Accession |
Description |
Interval |
E-value |
| SpoVB |
COG5841 |
Stage V sporulation protein SpoVB/SpoIIIF, required for spore cortex synthesis [Cell cycle ... |
1-535 |
1.46e-147 |
|
Stage V sporulation protein SpoVB/SpoIIIF, required for spore cortex synthesis [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 444543 [Multi-domain] Cd Length: 532 Bit Score: 434.20 E-value: 1.46e-147
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 1 MKEQSTTKGFAILSLAGMMVKVLSLLYIPFLRVIITDEGYGVYGAAYSVYVFIFVLTNSGIPVAISKLISELTAVGNYKD 80
Cdd:COG5841 1 MKKQSFLKGALILTAAGLISKILGAIYRIPLQNIIGDEGFGLYQMAYPIYGLFLTLATAGIPVAISKLVAEYNALGDYKG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 81 AVKTFKIARFMLLIIGIFMTGLMLLFSAPISKG-INQRRAYLSIIALSPAVLFTSIASAYRGYFQGWGNMTPTAISQVIE 159
Cdd:COG5841 81 ARRIFRVSLLLLLILGLVFFLLLFFGAPFIARLlLGDPRAYYSLRALAPALLIVPVMSVLRGYFQGLQNMTPTAVSQVIE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 160 QVGNTIFTLLFGIFLIKYGLEAGCAGATMGTSIGAFLSAIFLIIVYEKNKKIKIPSKFKEVEIKRHTNKEIISKIVNYGI 239
Cdd:COG5841 161 QIVRVIFILLLAYLLLPYGLEYAAAGATFGAVIGALAGLLVLLYYYRKRKKKLKRLLEKSKTKSKESSKDILKELLRIAI 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 240 PITVCVGMTYAGDLIDLSNTMGRLIVGGKLEGEASRLYGFLV-KYKQLINVPIAIITSLAVAILPAISSAAAINDRDTVK 318
Cdd:COG5841 241 PITLSSLVLPLFQLIDSFTVPRRLQAAGLSASEATSLYGILSgMAQPLVNLPTVLATALATSLVPAISEAFAKKDRKLVR 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 319 SKIRYAFRICFLIAIPSAVGLGILSGAIFNML-KFGDGAYLMKYGSIVVVLMSIMQIQTTILQSIGKLYTATLYAVIGIV 397
Cdd:COG5841 321 RRINQALRLTLLIGLPAAVGLAVLAEPINTLLfGNPEGGGILAILAPSAIFLSLQQVTTGILQGLGKQKIPVINLLIGLL 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 398 CKIVANYFLiaIPSLNILGAIYGSIIGYLVPILLNHRMLLKSLNIKFKLLEQAKKPAIASIFMGLVVILSNLFLSKFFnl 477
Cdd:COG5841 401 VKIILNYLL--VPLFGIYGAALATVIGYLVAAILNLAALKKYTGFKLDLRRRLLKPLLASLIMGIVVLLLYRLLSLFL-- 476
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*...
gi 499411769 478 hLKGYFANTIVTIIAVVLGMYAYLFAMVITGGITKEDFKVFPRKLNRFIPnfIMEKMK 535
Cdd:COG5841 477 -PESRLGALLATLIAVLVGAIVYLLLLLKLGLITKEELRRLPKGGKKLAR--LLRKLK 531
|
|
| MATE_SpoVB_like |
cd13124 |
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related ... |
11-442 |
5.49e-124 |
|
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; The integral membrane protein SpoVB has been implicated in the biosynthesis of the peptidoglycan component of the spore cortex in Bacillus subtilis. This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240529 [Multi-domain] Cd Length: 434 Bit Score: 370.26 E-value: 5.49e-124
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 11 AILSLAGMMVKVLSLLYIPFLRVIITDEGYGVYGAAYSVYVFIFVLTNSGIPVAISKLISELTAVGNYKDAVKTFKIARF 90
Cdd:cd13124 1 LILTIAGLISKILGAIYRIPLQNIIGDEGMGLYQMAYPIYGIFLTLATAGIPVAISKLVAEYNALGDYKGARRIFRVSLI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 91 MLLIIGIFMTGLMLLFSAPISKGI-NQRRAYLSIIALSPAVLFTSIASAYRGYFQGWGNMTPTAISQVIEQVGNTIFTLL 169
Cdd:cd13124 81 LLLILGLVFFLLLFFGAPFLAQLLlGDPRLAPVIRALAPAILIVPLLSVLRGYFQGLQNMTPTAVSQVIEQIVRVIVILV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 170 FGIFLIK--YGLEAGCAGATMGTSIGAFLSAIFLIIVYEKNKKIKIPSKFKEVEiKRHTNKEIISKIVNYGIPITVCVGM 247
Cdd:cd13124 161 LAYLLLPvgGGLYYAAAGATFGAVIGALAGLLVLLYYYRKKRRELKRLLRKSPR-SKISTKEILKELLSYAIPITLSSLI 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 248 TYAGDLIDLSNTMGRLIVGGKLEGEASRLYGFLV-KYKQLINVPIAIITSLAVAILPAISSAAAINDRDTVKSKIRYAFR 326
Cdd:cd13124 240 LPLLQLIDSFTVPRRLQAAGLSESEATALYGILTgRAQPLVQLPTVIATALSTSLVPAISEAYAKGDKKELRRRINQALR 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 327 ICFLIAIPSAVGLGILSGAIFNML-KFGDGAYLMKYGSIVVVLMSIMQIQTTILQSIGKLYTATLYAVIGIVCKIVANYF 405
Cdd:cd13124 320 LTLLIGLPAAVGLAVLAEPINTLLfGDSEGGLILQILAPSILFLSLQQVTAAILQGLGKVKIPVINLLIGLLVKIVLNYV 399
|
410 420 430
....*....|....*....|....*....|....*..
gi 499411769 406 LIAIpsLNILGAIYGSIIGYLVPILLNHRMLLKSLNI 442
Cdd:cd13124 400 LIPI--FGIYGAAIATVIGFLVAALLNLRALKKLLGF 434
|
|
| spore_V_B |
TIGR02900 |
stage V sporulation protein B; SpoVB is the stage V sporulation protein B of the bacterial ... |
8-476 |
5.59e-53 |
|
stage V sporulation protein B; SpoVB is the stage V sporulation protein B of the bacterial endopore formation program in Bacillus subtilis and various other Firmcutes. It is nearly universal among endospore-formers. Paralogs with rather high sequence similarity to SpoVB exist, including YkvU in B. subtilis and a number of proteins in the genus Clostridium. [Cellular processes, Sporulation and germination]
Pssm-ID: 274343 [Multi-domain] Cd Length: 488 Bit Score: 187.12 E-value: 5.59e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 8 KGFAILSLAGMMVKVLSLLYIPFLRVIITDEGYGVYGAAYSVYVFIFVLTNSGIPVAISKLISELTAVGNYKDAVKTFKI 87
Cdd:TIGR02900 3 KGTFILTIANLITRILGFIFRIVLSRILGAEGVGLYGMAMPIYFLFITLTTGGLPVAISKFVAEASAKNDRKNIKKILKV 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 88 ARFMLLIIGIFMTGLMLLFSAPISKG-INQRRAYLSIIALSPAVLFTSIASAYRGYFQGWGNMTPTAISQVIEQVGNTIF 166
Cdd:TIGR02900 83 SLIFTLIWSLIVTAIVFLLSPFIASTlLKDERSLYSLLVICPAMPFIALSSVLKGYFQGISNMKPPAYIQVIEQIVRISV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 167 TLLFGIFLIKYGLEAGCAGATMGTSIGAFLSAIFLIIVYEKNKKIKIPSKFKEVeikRHTNKEIISKIVNYGIPITVCVG 246
Cdd:TIGR02900 163 VALLISAFLPYGLEYAVAGAYLSLVLGELVSLLYLYFFFKRKKSFSIRFPFFDY---KSEGKALLFDLFSVSLPLTLSRF 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 247 MTYAGDLIDLSNTMGRLIVGGKLEGEASRLYGFLVKYK-QLINVPIAIITSLAVAILPAISSAAAINDRDTVKSKIRYAF 325
Cdd:TIGR02900 240 IGSLLYFLETLLVPQRLVIAGVTYREATSLYGKLSGMAmPLLTFPAVITSSLSTALVPDISEAMAKKNYSSIEKRINQAI 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 326 RICFLIAIPSAVGLGILSGAIFNML-KFGDGAYLMKYGSIVVVLMSIMQIQTTILQSIGKLYTATLYAVIGIVCKIVANY 404
Cdd:TIGR02900 320 KISLLLGLITTVILLVIPDELGALFyGRPDAGNFIRVLAPSFPFLYFSAPLQSILQGLGKQKVALRNSLIGAIVKIILLF 399
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 499411769 405 FLIAIPSLNILGAIYGSIIGYLVPILLNHRMLLKSLNIKFKLLEQAKKPAIASifmgLVVILSNLFLSKFFN 476
Cdd:TIGR02900 400 VLTSIPSINIYGYAITFIITSVLVTILNLAEIKKNIRITIDLSDFLIFALLGI----LVYLGLSLLKYIIFN 467
|
|
| MATE_Wzx_like |
cd13128 |
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
8-436 |
1.27e-26 |
|
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240533 [Multi-domain] Cd Length: 402 Bit Score: 111.87 E-value: 1.27e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 8 KGFAILSLAGMMVKVLSLLYIPFLRVIITDEGYGVYGAAYSVYVFIFVLTNSGIPVAISKLISELtavgNYKDAVKTFKI 87
Cdd:cd13128 3 KNSGWLFVGNIISKLLGFLVRVYLARYLGPEGFGILSLALAFVGLFSIFADLGLPTALVREIARY----RKEKIREIIST 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 88 ARFMLLIIGIFMTGLMLLFSAPISKGINQRRAYLSIIALSpaVLFTSIASAYRGYFQGWGNMTPTAISQVIEQVGNTIFT 167
Cdd:cd13128 79 SLVLKLILGILALLLLFLFAFLIAFYDPELVLLLYILALS--LPFSALNSLFRGIFQGFEKMKYIVIARIIESVLSLILA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 168 LLFGIFLikygleAGCAGATMGTSIGAFLSAIFLIIVYEKNKKIKIPSKFkeveikrhtNKEIISKIVNYGIPITVcvgm 247
Cdd:cd13128 157 LILVLLG------GGLIGFALAYLIASVLSAILLLYIYRKKILLPKFFSF---------DLKLAKELLRFSIPLAL---- 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 248 tyAGDLIDLSNTMGRLIVGGKLEGEASRLYGFLVKykqLINVPIAIITSLAVAILPAISSAAAiNDRDTVKSKIRYAFRI 327
Cdd:cd13128 218 --SGIFSLIYTRIDTIMLGYFLGDAAVGIYNAAYR---IAELLLFIPSAISTALFPRISELYK-NDKDELKKLLKKSFKY 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 328 CFLIAIPSAVGLGILSGAIFNML---KFGDGAYLMKYGSIVVVLMSIMQIQTTILQSIGKLYTATLYAVIGIVCKIVANY 404
Cdd:cd13128 292 LFLISLPIAIGLFLFAEPIITLLfgeEYLPAALVLQILAWGFLFIFLNGIFGSILQAIGKQKLTLKILLIGALLNVILNL 371
|
410 420 430
....*....|....*....|....*....|..
gi 499411769 405 FLiaIPSLNILGAIYGSIIGYLVPILLNHRML 436
Cdd:cd13128 372 LL--IPKYGIIGAAIATLISEFIIFILLLYLL 401
|
|
| MurJ |
COG0728 |
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope ... |
91-508 |
1.79e-21 |
|
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440492 [Multi-domain] Cd Length: 503 Bit Score: 97.53 E-value: 1.79e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 91 MLLIIGIFMTGLMLLFSAPISK----GINQRRAYLSII---ALSPAVLFTSIASAYRGYFQGWGNMTPTAISQVIeqvgN 163
Cdd:COG0728 87 LLLLVLLVLTLLGILFAPLLVKllapGFDPEKFALAVAltrIMFPYILFIGLSALLGGVLNARGRFAAPALAPVL----L 162
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 164 TIFTLLFGIFLIKYgLEAGCAGATMGTSIGAFLSAIFLIIVYEKNK-KIKIPSKFKEVEIKRhtnkeiiskIVNYGIPIT 242
Cdd:COG0728 163 NLVIIAGLLLLAPL-FGPGIYALAWGVLLGGVLQLLIQLPALRRLGlRLRPRFDLRDPGVRR---------VLKLMLPAL 232
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 243 VCVGMTYAGDLIDlsntmgRLIVGGKLEGEASRL-YGFLvkykqLINVPIAII-TSLAVAILPAISSAAAINDRDTVKSK 320
Cdd:COG0728 233 LGVSVSQINLLVD------TILASFLPEGSVSALyYADR-----LYQLPLGLFgVAIGTALLPRLSRAAAAGDLEEFRRT 301
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 321 IRYAFRICFLIAIPSAVGLGILSGAIFNML----KFGDG-----AYLMKYGSIVVVLMSIMQIQTTILQSIGKLYTATLY 391
Cdd:COG0728 302 LSRGLRLVLLLTLPAAVGLIVLAEPIVRLLfergAFTAEdtaltALALAAYALGLPAFALVKVLARAFYARQDTRTPVRI 381
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 392 AVIGIVCKIVANYFLiaIPSLNILGAIYGSIIGYLVPILLNHRMLLKSLNIKF--KLLEQAKKPAIASIFMGLVVILSNL 469
Cdd:COG0728 382 AVIAVVVNIVLNLLL--VPPLGHAGLALATSLSALVNALLLLVLLRRRLGGLPlrGILRTLLKLLLASLVMGAVLWLLLR 459
|
410 420 430
....*....|....*....|....*....|....*....
gi 499411769 470 FLSKFFNLHLkgyFANTIVTIIAVVLGMYAYLFAMVITG 508
Cdd:COG0728 460 LLGDWLGGGL---LGRLLALALLILVGAAVYFALLLLLG 495
|
|
| RfbX |
COG2244 |
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane ... |
4-427 |
4.42e-21 |
|
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441845 [Multi-domain] Cd Length: 366 Bit Score: 95.02 E-value: 4.42e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 4 QSTTKGFAILSLAGMMVKVLSLLYIPFLRVIITDEGYGVYGAAYSVYVFIFVLTNSGIPVAISKLISELTAvgnyKDAVK 83
Cdd:COG2244 2 KKLLKNTLWLLLGQLLGALLGFLLLPLLARLLGPEEYGLFALALSIVALLSVLADLGLSTALVRFIAEYRE----EELRR 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 84 TFKIARFMLLIIGIFMTGLMLLFSAPISKGINQRRAYLSIIALSPAVLFTSIASAYRGYFQGWGNMTPTAISQVIEQVGN 163
Cdd:COG2244 78 LLSTALLLRLLLSLLLALLLLLLAPFIAALLGEPELALLLLLLALALLLSALSAVLLALLRGLERFKLLALINILSSLLS 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 164 TIFTLLFgiflikYGLEAGCAGATMGTSIGAFLSAIFLIIvyeknkkikipskfkeveikrhtnkeiiskivnygipitv 243
Cdd:COG2244 158 LLLALLL------ALLGLGLWGLVLKYSLPLLLSGLLGLL---------------------------------------- 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 244 cvgmtyagdlidlSNTMGRLIVGGKLEGEASRLYGFLVKykqLINVPIAIITSLAVAILPAISSAAAINDRDTVKSKIRY 323
Cdd:COG2244 192 -------------LTNLDRLLLGALLGPAAVGIYSAAYR---LASLLLLLITALSQVLFPRLSRLLAEGDREELRRLYRK 255
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 324 AFRICFLIAIPSAVGLGILSGAIFNML---KFGDGAYLMKYGSIVVVLMSIMQIQTTILQSIGKLYTATLYAVIGIVCKI 400
Cdd:COG2244 256 ALRLLLLLGLPLALGLALLAPPLLSLLfgpEYAEAAPVLPILALGALFLALSGVLSNLLLALGRTRLLLIISLIGAVLNL 335
|
410 420
....*....|....*....|....*..
gi 499411769 401 VANYFLIaiPSLNILGAIYGSIIGYLV 427
Cdd:COG2244 336 VLNLLLI--PRYGLVGAAIATLLSYLV 360
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
11-431 |
7.12e-18 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 85.84 E-value: 7.12e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 11 AILSLAGMMVKVLSLLYIPFLRVIITDEGYGVYGAAYSVYVFIFVLTNsGIPVAISKLISELTAVGNYKDAVKTFKIARF 90
Cdd:cd12082 1 AAPLLLSMLLQTLYNLVDTFFLGRLLGDALAAVGLAFPLIALLIALGV-GLSVGTSALISQAIGAGDEEKARRVLVQSIV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 91 MLLIIGIFMTGLMLLFSAPISKGINQRRAYLS-----IIALSPAVLFTSIASAYRGYFQGWGNMTPTAISQVIEQVGNTI 165
Cdd:cd12082 80 LAILLGLLLAALLLFFSPLILSLLGAEEEVIElaatyLTILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSNLLNIL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 166 FTLLFgiFLIKYGLEAGCAGATMGTSIGAFLSAIFLIIVYEKNKKIKIPSKFkeveiKRHTNKEIISKIVNYGIPITVcv 245
Cdd:cd12082 160 LDPLL--IFGLGPPELGIAGAALATVISYVIGALLLLIYLRKGKKILKFKLS-----LLKPDLELLRRLLRIGLPSAI-- 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 246 gmtyAGDLIDLSNTMGRLIVGGKLEGEASRLYGFLVKYKQLINVPIAiitSLAVAILPAISSAAAINDRDTVKSKIRYAF 325
Cdd:cd12082 231 ----QNSLLSLGLLIIVAIVAAFGGAAALAAYTVAFRIASLAFMPAL---GLAQAALPVVGQNLGAGNFDRARRITWVAL 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 326 RICFLIAIPSAVGLGILSGAIFNMLKFGD-----GAYLMKYGSIVVVLMSIMQIQTTILQSIGKLYTAT-LYAVIGIVCK 399
Cdd:cd12082 304 LIGLLIGAVLGLLILLFPEPILSLFTNDPeflelAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSLiVSLLSYWVVR 383
|
410 420 430
....*....|....*....|....*....|..
gi 499411769 400 IVANYFLIAIpSLNILGAIYGSIIGYLVPILL 431
Cdd:cd12082 384 LPLAYVLAYL-GLGLYGIWLALVISLILAALV 414
|
|
| MATE_MurJ_like |
cd13123 |
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
93-438 |
6.29e-17 |
|
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli MurJ (MviN) has been identified as essential for murein biosynthesis. It has been suggested that MurJ functions as the peptidoglycan lipid II flippase which is involved in translocation of lipid-anchored peptidoglycan precursors across the cytoplasmic membrane, though results obtained in Bacillus subtilis seem to indicate that its MurJ homologs are not essential for growth. Some MviN family members (e.g. in Mycobacterium tuberculosis) possess an extended C-terminal region that contains an intracellular pseudo-kinase domain and an extracellular domain resembling carbohydrate-binding proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240528 [Multi-domain] Cd Length: 420 Bit Score: 82.89 E-value: 6.29e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 93 LIIGIFMTGLMLLFSAPISKGINQRRAYLSIIaLSPAVLFTSIASAYRGYFQGWGNMTPTAISQVIEQVGnTIFTLLFGI 172
Cdd:cd13123 90 LLGILFAPLLVKLLAPGFSGDKFELAVALTRI-MFPYLLFISLSALLGGILNAHGRFFAPALAPVLLNLV-IIAGLLLLA 167
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 173 FLIKYGLEagcaGATMGTSIGAFLSAIFLII-VYEKNKKIKIPSKFKEVEIKRhtnkeiiskIVNYGIPITVCVGMTYAG 251
Cdd:cd13123 168 PLFDLGIY----ALAWGVLLGGVLQLLVQLPaLRRLGFRFRPRLDFRDPGVRR---------VLKLMLPALLGVSVSQIN 234
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 252 DLIDlsntmgRLIVGGKLEGEASRLYgflvkYKQLIN-VPIAII-TSLAVAILPAISSAAAINDRDTVKSKIRYAFRICF 329
Cdd:cd13123 235 LLVD------TILASFLPEGSISALY-----YADRLYqLPLGIFgVAIATALLPRLSRLAAAGDLDEFRRTLSRGLRLVL 303
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 330 LIAIPSAVGLGILSGAIFNML----KFGDG-----AYLMKYGSIVVVLMSIMQIQTTILQSIGKLYTATLYAVIGIVCKI 400
Cdd:cd13123 304 FLLLPAAVGLIVLAEPIVRLLfergAFTAEdtlmtASALAAYALGLPAFALVKLLSRAFYALKDTKTPVKIAVIAVAVNI 383
|
330 340 350
....*....|....*....|....*....|....*...
gi 499411769 401 VANYFLiaIPSLNILGAIYGSIIGYLVPILLNHRMLLK 438
Cdd:cd13123 384 LLNLLL--IKPLGHVGLALATSLSAWVNALLLLVLLRR 419
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
44-431 |
1.23e-14 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 75.95 E-value: 1.23e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 44 GAAYSVYVFIFVLTNsGIPVAISKLISELTAVGNYKDAVKTFKIARFMLLIIGIFMTGLMLLFSAPISKGINQR------ 117
Cdd:COG0534 47 GLAFPIFFLLIALGI-GLGVGGTALVAQALGAGDREEARRVLGQALLLALLLGLLLTLLGLLFAPPLLRLLGADpevlal 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 118 -RAYLSIIALSpaVLFTSIASAYRGYFQGWGNMTPTAISQVIEQVGNTIFTLLFgIFlikyGLEAGCAGATMGTSIGAFL 196
Cdd:COG0534 126 aRDYLRIILLG--LPFLLLFNVLNGILRGLGDTKTPMIIMLIGNVLNIVLDPLL-IF----GGGLGVAGAALATVISQAV 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 197 SAIFLIIVYEKNKKIKIPSKFkeveiKRHTNKEIISKIVNYGIPITVCVGMTYAGDLI--DLSNTMGRLIVGGklegeas 274
Cdd:COG0534 199 SALLLLYYLFRKRSLLRLRLR-----DLRPDRKILKRILRIGLPAGLQQLAESLGFLVlnALVARLGTAAVAA------- 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 275 rlYGFLVkykQLINVPIAIITSLAVAILPAISSAAAINDRDTVKSKIRYAFRICFLIAIPSAVGLGILSGAIFNMlkFGD 354
Cdd:COG0534 267 --YGIAL---RIESLAFMPALGLGQAAQPLVGQNLGAGDYDRARRAARLALLLALGIGLLLALLLFLFPEPIIGL--FTD 339
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 355 -------GAYLMKYGSIVVVLMSIMQIQTTILQSIGKLYTATLYAVIGIVCKIVANYFLIAIPSLNILGAIYGSIIGYLV 427
Cdd:COG0534 340 dpevialAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIISLLRLWLVRLPLAYLLAFLGLGLTGVWLALPIGEVL 419
|
....
gi 499411769 428 PILL 431
Cdd:COG0534 420 RALL 423
|
|
| Polysacc_synt |
pfam01943 |
Polysaccharide biosynthesis protein; Members of this family are integral membrane proteins. ... |
7-219 |
3.60e-14 |
|
Polysaccharide biosynthesis protein; Members of this family are integral membrane proteins. Many members of the family are implicated in production of polysaccharide. The family includes RfbX part of the O antigen biosynthesis operon. The family includes SpoVB from Bacillus subtilis, which is involved in spore cortex biosynthesis.
Pssm-ID: 426523 [Multi-domain] Cd Length: 274 Bit Score: 72.72 E-value: 3.60e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 7 TKGFAILSLAGMMVKVLSLLYIPFLRVIITDEGYGVYGAAYSVYVFIFVLTNSGIPVAISKLISEltAVGNYKDAVKTFK 86
Cdd:pfam01943 2 LKNVIVLLLSQLITYLLAFVTLPYLARILGPEGFGLYAFALAFVGLLTIFTDFGFNAALVREIAK--YREKYELVSLYWL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 87 IARFMLLIigifmtGLMLLFSAPISKGINQRR--AYLSIIALSPAVLFTSIASAYRGYFQGWGNMTPTAISQVIEQVGNT 164
Cdd:pfam01943 80 NALLVKLV------LVLLFLLLPLIAAFLGLPelAVLYRILALMFLLLPGVVQFRRGLFQGLERMKYALISQIVESLSRV 153
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 499411769 165 IFTLLFgiFLIKYGLEAGCAGATMGTSIGAFLSAIFLIIVYEKNKKIKIPSKFKE 219
Cdd:pfam01943 154 ILVFIA--VFLPGDIVAALLYQVLAALVGGIIALAVLRKIFRPRFVFPSLKLVRK 206
|
|
| MATE_tuaB_like |
cd13127 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This ... |
6-445 |
3.12e-13 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This family might function as a translocase for lipopolysaccharides and participate in the biosynthesis of cell wall components such as teichuronic acid. The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240532 [Multi-domain] Cd Length: 406 Bit Score: 71.36 E-value: 3.12e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 6 TTKGFAILSLAGMMVKVLSLLYIPFLRVIITDEGYGVYGAAYSVYVFIFVLTNSGIPVAiskLISELTAVGNYKDAVKTF 85
Cdd:cd13127 1 AVSGAFWSAISQVVVQLLQFVVTIILARLLTPEDFGLVAMATVFIAFAQLFSDLGLSSA---LIQRKDLTEEDLSTVFWL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 86 kiarfmLLIIGIFMTGLMLLFSAPISKGINQRRAYLSIIALSPAVLFTSIASAYRGYFQGWGNMTPTAISQVIeqvgNTI 165
Cdd:cd13127 78 ------NLLLGLLLYLLLFLLAPLIAAFYNEPELIPLLRVLSLSFLLSGLGSVPRALLQRELRFKKLAIIELI----STL 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 166 FTLLFGIFLIKYGleAGCAGATMGTSIGAFLSAIFLIIVYeknkKIKIPSKFkeveikrhtNKEIISKIVNYGIPITVCV 245
Cdd:cd13127 148 VSGVVAIVLALLG--FGVWALVAQQLVGALVSTVLLWILS----RWRPRLSF---------SLASLKELLSFGSKLLGSN 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 246 GMTYagdlidLSNTMGRLIVGGKLEGEASRLYGFLvkyKQLINVPIAIITS-LAVAILPAISSAAaiNDRDTVKSKIRYA 324
Cdd:cd13127 213 LLNY------FSRNLDNLIIGKFLGAAALGYYSRA---YRLALLPVQNITGpITRVLFPALSRLQ--DDPERLRRAYLKA 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 325 FRICFLIAIPSAVGLGILSGAIFNMLkFGDG----AYLMKYGSIVVVLMSIMQIQTTILQSIGKLYTATLYAVIGIVCKI 400
Cdd:cd13127 282 LRLLALITFPLMVGLALLAEPLVLLL-LGEKwlpaVPILQILALAGLFQPLSSLNGSLLLALGRTDLLLKLGLIKAVLTV 360
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 499411769 401 VAnyFLIAIPsLNILGAIYGSIIGYLVPILLNHRMLLKSLNIKFK 445
Cdd:cd13127 361 LA--LLIGIP-YGIIGVAIAYVIASLLSFPLNLYLAGRLIGISLL 402
|
|
| Polysacc_synt_C |
pfam14667 |
Polysaccharide biosynthesis C-terminal domain; This family represents the C-terminal integral ... |
358-509 |
4.25e-13 |
|
Polysaccharide biosynthesis C-terminal domain; This family represents the C-terminal integral membrane region of polysaccharide biosynthesis proteins.
Pssm-ID: 434111 [Multi-domain] Cd Length: 141 Bit Score: 66.44 E-value: 4.25e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 358 LMKYGSIVVVLMSIMQIQTTILQSIGKLYTATLYAVIGIVCKIVANYFLiaIPSLNILGAIYGSIIGYLVPILLNHRMLL 437
Cdd:pfam14667 1 VLQILALSIIFLSLSTVLTSILQGLGRTKLALIALLIGALVKLILNLLL--IPLFGIVGAAIATVISLLVVALLNLYYLR 78
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 499411769 438 KSLNIKFKLLEQAkKPAIASIFMGLVVILSNLFLSKFFNlhlkgyfaNTIVTIIAVVLGMYAYLFAMVITGG 509
Cdd:pfam14667 79 RYLGLRLLLRRLL-KPLLAALVMGIVVYLLLLLLGLLLG--------LALALLLAVLVGALVYLLLLLLLKL 141
|
|
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
53-431 |
9.08e-11 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 64.02 E-value: 9.08e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 53 IFVLTN--SGIPVAISKLISELTAVGNYKDAVKTFKIARFMLLIIGIFMTGLMLLFSAPISKGIN-------QRRAYLSI 123
Cdd:cd13138 49 IFLLTAigMGLSMGGTILISQYIGAKDEEKAKKAVGTLLVLFLILGIVLTILGLLFAPPILRLMNtpaeileLAVSYLRI 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 124 IALSpaVLFTSIASAYRGYFQGWGNMTPTAISQVIEQVGNTIFTLLFgIFLIKYGLeagcAGATMGTSIGAFLSAIFLII 203
Cdd:cd13138 129 CFLG--IPFIFGYNAYSAILRGLGDSKTPLYFVIIACVLNIILDLLF-IAVFHMGV----AGAALATVIAQAISVLLALY 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 204 VYEKNKKIkIPSKFKEVeikrHTNKEIISKIVNYGIPITVCVGMTYAGDLI--DLSNTMGRLIVGGklEGEASRLygflv 281
Cdd:cd13138 202 YLRKKKLP-FKLSLKDF----RFDKEILKEILKIGLPSALQQSLVSISFLIinSIVNSYGVVASAA--YGIANKI----- 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 282 kykqlinvpIAIITSLAVAILPAISSAAAIN----DRDTVKSKIRYAFRICFLIAIPSAVGLGILSGAIFNMLkFGD--- 354
Cdd:cd13138 270 ---------NSFAFLPPSAIGQAVSTFVAQNigagKIERAKKGLRTGIIISLIIGLIIILLVFFFAPQLLGLF-TSDpev 339
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 355 ---GAYLMKYGSIVVVLMSIMQIQTTILQSIGKLYTATLYAVIGI-VCKIVANYFLIAIPSLNILGAIYGSIIGYLVPIL 430
Cdd:cd13138 340 ieiGAEYLRIYSIDYILFGILFVFNGLFRGLGKTKFPMIISILRLwLVRIPLAYLLSRLTGLGLFGIWLAMPISNILSAI 419
|
.
gi 499411769 431 L 431
Cdd:cd13138 420 I 420
|
|
| MurJ |
pfam03023 |
Lipid II flippase MurJ; Peptidoglycan synthesis (PG) biosynthesis involves the formation of ... |
94-466 |
1.69e-10 |
|
Lipid II flippase MurJ; Peptidoglycan synthesis (PG) biosynthesis involves the formation of peptidoglycan precursor lipid II (undecaprenyl-pyrophosphate-linked N-acetyl glucosamine-N-acetyl muramic acid-pentapeptide) on the cytosolic face of the cell membrane. Lipid II is then translocated across the membrane and its glycopeptide moiety becomes incorporated into the growing cell wall mesh. MviN, renamed as MurJ, is a lipid II flippase essential for cell wall peptidoglycan synthesis. MurJ belongs to the MVF (mouse virulence factor) family of MOP superfamily transporters, which also includes the MATE (multidrug and toxic compound extrusion) transporter and eukaryotic OLF (oligosaccharidyl-lipid flippase) families. In addition to the canonical MOP transporter core consisting of 12 transmembrane helices (TMs), MurJ has two additional C-terminal TMs (13 and 14) of unknown function. Structural analysis indicates that the N lobe (TMs 1-6) and C lobe (TMs 7-14) are arranged in an inward-facing N-shape conformation, rather than the outward-facing V-shape conformation observed in all existing MATE transporter structures. Furthermore, a hydrophobic groove is formed by two C-terminal transmembrane helices, which leads into a large central cavity that is mostly cationic. Mutagenesis studies, revealed a solvent-exposed cavity that is essential for function. Mutation of conserved residues (Ser17, Arg18, Arg24, Arg52, and Arg255) at the proximal site failed to complement MurJ function, consistent with the idea that these residues are important for recognizing the diphosphate and/or sugar moieties of lipid II. It has also been suggested that the chloride ion in the central cavity and a zinc ion at the beginning of TM 7 might be functionally important.
Pssm-ID: 397249 [Multi-domain] Cd Length: 451 Bit Score: 63.08 E-value: 1.69e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 94 IIGIFMTGLMLLFSAPISKGINQRRAYLSIIALSPAVLFTSIASAYRGYFQGWGNMTPTAISQVIEQVGnTIFTLLFgiF 173
Cdd:pfam03023 72 LIGILAAPWLIRLLAPGFDPETFSLAVSLLRITFPYLLLVSLSAVFGAVLNARKKFFAPSFSPVLLNVG-VILTLLL--L 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 174 LIKYGLEAgcAGATMGTSIGAFLSAIFLIIVYeknKKIKIPSKfkeveIKRHTNKEIISKIVNYGIPITVCVGMTYAGDL 253
Cdd:pfam03023 149 ANYLGNAI--YALAIGVLIGGVLQLLVQLPFL---KKAGLLLK-----PRFGFRDKGLKRFLKLMLPTLLGVSVSQLNLL 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 254 IDLSNTMGRLIVGGKLEGEASRLYGFlvkykqlinvPIAIIT-SLAVAILPAISSAAAINDRDTVKSKIRYAFRICFLIA 332
Cdd:pfam03023 219 IDTFLASFLAPGSVSYLYYADRIYQL----------PLGIFGvSISTVLLPRLSRHAADGDWDEFRDLLDQAIRLTLLLM 288
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 333 IPSAVGLGILSGAI---------FNMLKFGDGAYLMKYGSIVVVLMSIMQIQTTILQSIGKLYTATLYAVIGIVCKIVAN 403
Cdd:pfam03023 289 IPVSFGLLVLSIPIvsllfergnFSPEDVTATAEVLAAYALGLIPYALVKLLSRVFYAREDTKTPFKISLISAVLNILLS 368
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 499411769 404 YFLiaIPSLNILGAIYGSIIGYLVPILLNHRMLLKSLNIKFKL--LEQAKKPAIASIFMGLVVIL 466
Cdd:pfam03023 369 LLL--LPPLGVAGLALATSLSSLIGLVFLYYILRKRLGGFDLRgiKTFLASLVVPTALMAGVILL 431
|
|
| MATE_like_8 |
cd13134 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
50-240 |
1.93e-08 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240539 [Multi-domain] Cd Length: 438 Bit Score: 56.74 E-value: 1.93e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 50 YVFIFVLTNSGIPVAISKLISELTAVGNYKDAVKTFKIARFMLLIIGIFMTGLMLLFSAPI-------SKGINQRRAYLS 122
Cdd:cd13134 47 ILFLLILIFSFISTGTSILIAQYLGAKDKKKARQIAGVALLFNLLLGLVFSLLLLFFGAELlrlmglpPELLALGSTYLR 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 123 IIALSpaVLFTSIASAYRGYFQGWGNMTPTAISQVIEQVGNTI--FTLLFGIFLI-KYGLeagcAGATMGTSIGAFLSAI 199
Cdd:cd13134 127 IVGGS--LFLQALSLTLSAILRSHGRTKIPMYVSLIMNILNIVgnYLLIFGWFGLpKLGV----AGVAISTVISRAVGLV 200
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 499411769 200 FLIIVYEKNKKIKIPSKFkeveiKRHTNKEIISKIVNYGIP 240
Cdd:cd13134 201 LLFILLFRKLKIRFRLKD-----LRPFPKKLLKKILKIGLP 236
|
|
| murJ_mviN |
TIGR01695 |
murein biosynthesis integral membrane protein MurJ; This model represents MurJ (previously ... |
90-507 |
1.40e-07 |
|
murein biosynthesis integral membrane protein MurJ; This model represents MurJ (previously MviN), a family of integral membrane proteins predicted to have ten or more transmembrane regions. Members have been suggested to act as a lipid II flippase, translocated a precursor of murein. However, it appears FtsW has that activity. Flippase activity for MurJ has not been shown. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273763 [Multi-domain] Cd Length: 502 Bit Score: 53.87 E-value: 1.40e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 90 FMLLIIGIFMTGLMLLFSAPISKGINQRRAYLSIIALSPAVLFTSIASAYRGYFQGWGNMTPTAISQVIEQVGnTIFTLL 169
Cdd:TIGR01695 94 LLVVLIGIFFAPFVISLLAPGFADETRSLAVSLTRIMFPYLLLISLAAVFGGILNARKRFFIPSFSPILFNIG-VILSLL 172
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 170 FGIflikYGLEAGCAGATMGTSIGAFLSAIFLIIVYEKNKKIKIPskfkeveiKRHTNKEIISKIVNYGIPITVCVGMTY 249
Cdd:TIGR01695 173 FFD----WNYGQYSLALAIGVLIGGVAQLLIQLPFLRKAGFLLKP--------RFNFRDPGLKRFLKLFLPTTLGSSASQ 240
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 250 AGDLIDLsntmgrlIVGGKLEGEASRLYGFLVKYKQLinvPIAIIT-SLAVAILPAISSAAAINDRDTVKSKIRYAFRIC 328
Cdd:TIGR01695 241 ITLLINT-------ALASFLEIGSVSALYYANRIYQL---PLGIFGiSLSTVLLPKLSRHASEGNWNELRDLLNQGIRLS 310
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 329 FLIAIPSAVGLGILSGAI---------FNMLKFGDGAYLMKYGSIVVVLMSIMQIQTTILQSIGKLYTATLYAVIGIVCK 399
Cdd:TIGR01695 311 LLLTIPSSFGLLILSIPIvsllfergaFSEEDTVMTATILAAYGLGLIFYSLQKVLLRAFYARKDTRTPFINSVISVVLN 390
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 400 IVANYFLiaIPSLNILGAIYGSIIGYLVPILLNHRMLLKSLnIKFKLLEQAKKPAIASIFMGLVVILSNLFLSKFFNLHL 479
Cdd:TIGR01695 391 ALLSLLL--IFPLGLVGIALATSAASMVSSVLLYLMLNRRL-KGILPFGVLKVLAKLVIASAIIGGVLYLIVSVSLGGVL 467
|
410 420
....*....|....*....|....*...
gi 499411769 480 KGYFANTIVTIIAVVLGMYAYLFAMVIT 507
Cdd:TIGR01695 468 VKNLLGLLAIGLIGLLVYFLGLALLKIE 495
|
|
| MATE_like_6 |
cd13146 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
52-437 |
1.96e-06 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240551 [Multi-domain] Cd Length: 433 Bit Score: 50.09 E-value: 1.96e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 52 FIFVLTNSGIPVAISKLISELTAVGNYKDAVKTFKIARFMLLIIGIFMTGLMLLFSAPISKGINQRRAYLS-----IIAL 126
Cdd:cd13146 57 MIFLALGNGIQVGVSSLLARAIGAQRAKELDQAADSGLALALLAATVIVVLGYIFAEPLLQLLGAKGLLLEyaleyFYYS 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 127 SPAVLFTSIASAYRGYFQGWGNMTPTAISQVIEQVGNTIFTLLFgIFLIKYGLeagcAGATMGTSIGAFLSAIFLIIVYe 206
Cdd:cd13146 137 LPGVPFIMLIGVLMGVLQGEGRTKYMMMAMLIGTVVNIVLDPIL-IFVFDMGV----KGAALATVLAQAISLLYLLYVF- 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 207 KNKKIKIPSKFKEVEIkrhtNKEIISKIVNYGIPITVcVGMTYAGDLIDLSNTMGRLIVggkLEGEASRLYGflvKYKQL 286
Cdd:cd13146 211 LIGKSNVTIHIKLSNI----SSSVIVEILRVGLPQML-LQLISSISFLIYNRIIIDIDP---VAMTAFTLVG---RLDQF 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 287 INVPiaiITSLAVAILPAISSAAAINDRDTVKSKIRYAFRICFLIAIPSAVGLGILSGAIFNML----KFGDGAYL-MKY 361
Cdd:cd13146 280 ILIP---IFAISSALLTIAGQNWGRGNYDRMLQILMTAVILGIVVVLVLVLGYVLVAPWLFSLFttvpEVVAYAVLqVRT 356
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 499411769 362 GSIVVVLMSIMQIQTTILQSIGKLYTATLYAVIGI-VCKIVANYFLIAIPSLNILGAIYGSIIGYLVPILLNHRMLL 437
Cdd:cd13146 357 MALALPFVAISILVTEFFQAIGKAWPSLLLTLIRHvFLSVPVVYLLAYVFGKGITGVYFGIVSANFFTALLAMFWGL 433
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
285-474 |
3.38e-06 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 49.43 E-value: 3.38e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 285 QLINVPIAIITSLAVAILPAISSAAAINDRDTVKSKIRYAFRICFLIAIPSAVGLGILSGAIFNMLKFGD-----GAYLM 359
Cdd:cd13137 44 QVLWLLLVLNMALGTGTVALVSQSYGAGDYERARRALGQSLLLALLLSLPLALLGLLFAEPLLRLLGADPevialALTYL 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 360 KYGSIVVVLMSIMQIQTTILQSIGKLYTATLYAVIGIVCKIVANYFLI----AIPSLNILGAIYGSIIGYLVP------I 429
Cdd:cd13137 124 RIVLLGIPFFFLSLVGNAALRGAGDTKTPMYIMIIVNVLNIVLDYVLIfglwGFPGLGVAGAALATVISRVVGallllfL 203
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 499411769 430 LLNHRMLLKS----LNIKFKLLEQAKKPAIASIFMGLVVILSNLFLSKF 474
Cdd:cd13137 204 LLRGRLPIKIsfkgFRLDRKIIKKLLRIGLPAGLEQLLRSLGFLVLLAI 252
|
|
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
285-476 |
3.76e-06 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 49.38 E-value: 3.76e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 285 QLINVPIAIITSLAVAILPAISSAAAINDRDTVKSKIRYAFRICFLIAIPSAVGLGILSGAIFNMLKFGDGA------YL 358
Cdd:cd13138 47 PIIFLLTAIGMGLSMGGTILISQYIGAKDEEKAKKAVGTLLVLFLILGIVLTILGLLFAPPILRLMNTPAEIlelavsYL 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 359 MKYgSIVVVLMSIMQIQTTILQSIGKLYTATLYAVIGIVCKIVANYFLIAIPSLNILGAIYGSIIGYLVP-----ILLNH 433
Cdd:cd13138 127 RIC-FLGIPFIFGYNAYSAILRGLGDSKTPLYFVIIACVLNIILDLLFIAVFHMGVAGAALATVIAQAISvllalYYLRK 205
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 499411769 434 RML-----LKSLNIKFKLLEQAKKPAIASIFMGLVVILSNLFLSKFFN 476
Cdd:cd13138 206 KKLpfklsLKDFRFDKEILKEILKIGLPSALQQSLVSISFLIINSIVN 253
|
|
| MATE_like_12 |
cd13142 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
50-427 |
8.92e-06 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240547 [Multi-domain] Cd Length: 444 Bit Score: 48.34 E-value: 8.92e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 50 YVFIFVLTNSGIPVAISKLISELTAVGNYKDAVKTFKIARFMLLIIGIFMTGLMLLFSAPISKG--------INQRRAYL 121
Cdd:cd13142 55 LIFLFISLGGGLTVAGTALVAQYTGAGDYDKANKVAGQTFSFVIILSLILAVLGYILSRPLLLLligapeevYPLALAYL 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 122 SIIALspAVLFTSIASAYRGYFQGWGN-MTP---TAISQVIEQVGNTIFTLLFGIFlikygLEAGCAGATMGTSIGAFLS 197
Cdd:cd13142 135 RIIFL--GLPFMFIFFVFNSLLRGIGDtKTPmkiMFGSVLLNVILDPLLIFGIGPF-----PGLGVAGAALATVISRGIA 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 198 AIF-LIIVYEKNKKIKIpsKFKEVEIKRhtnkEIISKIVNYGIPITVCVGMTYAGDLIDLS--NTMGRLIVGGklegeas 274
Cdd:cd13142 208 AVIgLYLLFKGRVGLKI--SLRDLKPDW----EWLKKIFRIGLPSSIEQSARALGFTVMTAlvAGFGTVVVAA------- 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 275 rlYGflvkykqlinvpIAI-ITSLAVAILPAISSAAAI--------NDRDTVKSKIRYAFRICFLIAIPSAVGLGILSGA 345
Cdd:cd13142 275 --YG------------IGNrIISLVFLPAFGLARATSTmvgqnlgaGQIDRAEEIVKKAALLIFLILVIGGVLAFLFAEP 340
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 346 IF-----NMLKFGDGAYLMKYGSIVVVLMSIMQIQTTILQSIGKLYTATLYAVIGI-VCKIVANYFLIAIPSLNILGAIY 419
Cdd:cd13142 341 IVrvfinDPEVIKEGADFLRIVAPSFPFFGLFQVINGAFRGSGHTLTAMIISILRLwVIRIPLAYLLAYVLGLGVTGIWI 420
|
....*...
gi 499411769 420 GSIIGYLV 427
Cdd:cd13142 421 AMAISNIV 428
|
|
| MATE_like_10 |
cd13125 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This ... |
6-350 |
9.73e-06 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This family might function as a translocase for lipopolysaccharides, such as O-antigen. The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240530 [Multi-domain] Cd Length: 409 Bit Score: 47.92 E-value: 9.73e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 6 TTKGFAILSLAGMmvkVLSLLYIPFLRVIITDEGYGVYGAAYSVYVFIFVLTNSGIPVAISKLISEltAVGNYKDAVKTF 85
Cdd:cd13125 2 VSSLSGISTLIKI---LAGLIINKVVAVYLGPSGVALLGQLQNFVTILQTIAGGGINNGVVKYTAE--YKDDEEKLARVW 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 86 KIARFMLLIIGIFMTGLMLLFSAPISKGI-NQRRAYLSIIALSPAVLFTSIASAYRGYFQGWGNMTPTAISQVIeqvGNT 164
Cdd:cd13125 77 STAFRITLILSILGGLLLLLFSKPLSSLLfGDIDYSWVFILLGLALPLFALNNLLLAILNGLKEIKRYALINII---SSL 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 165 IFTLLFGIFLIKYGLEagcaGATMGTSIGAFLSAIFLIIVyeknkkIKIPSKFKEVEIKRHTNKEIISKIVNYGIpitvc 244
Cdd:cd13125 154 IGLLVSVLLVYFYGLK----GALLALVLNQSLIFLVTLIY------SRKQPWFKLKYLWGRLDKDIIKKLLKFSL----- 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 245 VGMTyAGDLIDLSNTMGRLIVGGKLEGEASRLYGFLVKykqLINVPIAIIT-SLAVAILPAISsaaAINDRDTVKSKIRY 323
Cdd:cd13125 219 MALV-SALSLPLSQIIVRNILIRQLGWEAAGYWQAVWK---ISDVYLGFITtALSTYYLPRLS---AIKDNKELKREVNK 291
|
330 340
....*....|....*....|....*..
gi 499411769 324 AFRICFLIAIPSAVGLGILSGAIFNML 350
Cdd:cd13125 292 QLKVILPLVAIGALLIYLLRDLIIQIL 318
|
|
| MATE_like_1 |
cd13140 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
76-241 |
9.95e-06 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240545 [Multi-domain] Cd Length: 435 Bit Score: 47.91 E-value: 9.95e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 76 GNYKDAVKTFKIARFMLLIIGIFMTGLMLLFSAPI--------SKGINQRRAYLSIIAlsPAVLFTSIASAYRGYFQGWG 147
Cdd:cd13140 75 KDEKEARKYARNALQLNLLLGILYGLLLLLFAKPLigffnlgdAEVISLAITYLRIVA--LGLIFSFLNPVFTGIFNALG 152
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 148 NMTPTAISQVIEQVGNTIFTLLFgIFLIKYGLEAGCAGATMGTSIGAFLSAIFLIIVYEKNKKIkipskFKEVEIKRHTN 227
Cdd:cd13140 153 DSKTPFIINAIGLVLNIILDPLL-IFGFGPFPALGVAGAALATVLAQAIVFLLFLYALKKKKGL-----FLKIRILKRPD 226
|
170
....*....|....
gi 499411769 228 KEIISKIVNYGIPI 241
Cdd:cd13140 227 RKYIKEILKLGLPV 240
|
|
| MATE_like_8 |
cd13134 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
294-446 |
1.03e-05 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240539 [Multi-domain] Cd Length: 438 Bit Score: 47.88 E-value: 1.03e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 294 ITSLAVAILPAISSAAAI--------NDRDTVKSKIRYAFRICFLIAIPSAVGLGILSGAIFNMLK-----FGDGAYLMK 360
Cdd:cd13134 47 ILFLLILIFSFISTGTSIliaqylgaKDKKKARQIAGVALLFNLLLGLVFSLLLLFFGAELLRLMGlppelLALGSTYLR 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 361 YGSIVVVLMSIMQIQTTILQSIGKLYTATLYAVIGIVCKIVANYFLI----AIPSLNILGAIYGSIIGYLVPILLNHRML 436
Cdd:cd13134 127 IVGGSLFLQALSLTLSAILRSHGRTKIPMYVSLIMNILNIVGNYLLIfgwfGLPKLGVAGVAISTVISRAVGLVLLFILL 206
|
170
....*....|
gi 499411769 437 LKSLNIKFKL 446
Cdd:cd13134 207 FRKLKIRFRL 216
|
|
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
43-210 |
1.61e-05 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 47.45 E-value: 1.61e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 43 YGAAYSVYVFIFVLTnSGIPVAISKLISELTAVGNYKDAVKTFKIARFMLLIIGIFMTGLMLLFSAPI-------SKGIN 115
Cdd:cd13138 263 YGIANKINSFAFLPP-SAIGQAVSTFVAQNIGAGKIERAKKGLRTGIIISLIIGLIIILLVFFFAPQLlglftsdPEVIE 341
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 116 QRRAYLSIIALSpaVLFTSIASAYRGYFQGWGNMTPTAISQVIEqvgnTIFTLLFGIFLIKYGLEAGCAGATMGTSIGAF 195
Cdd:cd13138 342 IGAEYLRIYSID--YILFGILFVFNGLFRGLGKTKFPMIISILR----LWLVRIPLAYLLSRLTGLGLFGIWLAMPISNI 415
|
170
....*....|....*
gi 499411769 196 LSAIFLIIVYEKNKK 210
Cdd:cd13138 416 LSAIICIIYYRKGRW 430
|
|
| MATE_MepA_like |
cd13143 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
76-420 |
2.35e-05 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.
Pssm-ID: 240548 [Multi-domain] Cd Length: 426 Bit Score: 46.73 E-value: 2.35e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 76 GNYKDAVKTFKIARFMLLIIGIFMTGLMLLFSAPISKGIN-------QRRAYLSIIALSPAVLFTSIASAYrgYFQGWGN 148
Cdd:cd13143 75 GDREKANRIFSTALLLSLILGLLLTILGLLFLDPLLRLLGasgellpYAVDYLRIILLGAPFTILSSVLNN--LLRAEGK 152
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 149 MTPTAISQVIEQVGNTIFTLLFgIFLIKYGLeagcAGATMGTSIGAFLSAIFLIIVYEKNKKIKIPSKFkeveiKRHTNK 228
Cdd:cd13143 153 PKLAMLGMLIGAVLNIILDPLF-IFVLGLGI----AGAALATVIAQLISLLLLLLYFFRGKSLLKLSLL-----RFKLSL 222
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 229 EIISKIVNYGIPitvcVGMTYAGdlIDLSNTMGRLIVGGKLEGEASRLYGFLVKykqLINVPIAIITSLAVAILPAISSA 308
Cdd:cd13143 223 KIIKEILALGFP----SFLMQLS--SSVVTIVLNLTLLGYGGDIGVAAFGIVTR---ILTFLFLPLIGLSQGLQPIIGYN 293
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 309 AAINDRDTVKSKIRYAFRICFLIAIPSAVGLGILSGAIFNMlkFGDGAYLMKYG-------SIVVVLMSIMQIQTTILQS 381
Cdd:cd13143 294 YGAGNYDRVKQALKLALIVALIYGLVLFLILLLFPEQIVSL--FTDDPELIALAarilrifLLAFPLAGINIVLSGYFQA 371
|
330 340 350
....*....|....*....|....*....|....*....
gi 499411769 382 IGKLYTATLYAVIGIvckivanyFLIAIPSLNILGAIYG 420
Cdd:cd13143 372 IGKAKRAALLSLLRQ--------GLFLIPLLLILPRLFG 402
|
|
| MATE_NorM_like |
cd13131 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio ... |
48-241 |
3.81e-05 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Vibrio cholerae NorM and functions most likely as a multidrug efflux pump, removing xenobiotics from the interior of the cell. The pump utilizes a cation gradient across the membrane to facilitate the export process. NorM appears to bind monovalent cations in an outward-facing conformation and may subsequently cycle through an inward-facing and outward-facing conformation to capture and release its substrate.
Pssm-ID: 240536 [Multi-domain] Cd Length: 435 Bit Score: 46.34 E-value: 3.81e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 48 SVYVFIFVLTnSGIPVAISKLISELTAVGNYKDAVKTFKIARFMLLIIGIFMtGLMLLFSAPISKGINQR-------RAY 120
Cdd:cd13131 46 SLWFPVFTFG-MGLLLAVTPLVAQAHGAGDRRRIRRAVRQGLWLALLLSLPL-MLLLWLAPPILPLMGQEpevaaiaRGY 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 121 LSIIALS--PAVLFTsiasAYRGYFQGWGN----MTPTAISQVIEQVGNTIFtlLFGIF-LIKYGLeAGCAGATMGTSIG 193
Cdd:cd13131 124 LLALAWGipPALLFQ----VLRSFLDALGRtrpaMVITLLALVLNIPLNYVL--IFGKFgLPALGG-AGAGLATAIVYWL 196
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 499411769 194 AFLSAIFLIIVYEKNKKIKIPSKFkeveikRHTNKEIISKIVNYGIPI 241
Cdd:cd13131 197 MFLALAFYIRRHKRFRRYRLFARF------WRPDWARLKELLRLGLPI 238
|
|
| MATE_like_7 |
cd13133 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
44-431 |
5.33e-05 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240538 [Multi-domain] Cd Length: 438 Bit Score: 45.60 E-value: 5.33e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 44 GAAYSVYVFIFVLTNSGIPVAISKLISEltavGNYKDAVKTFKIARFMLLIIGIFMTGLMLLFSAPISKGIN----QRRA 119
Cdd:cd13133 47 GVLYFAILMLFFGLSSGVQVFVAQYNGA----GRYSRIGRVLWQGLYFSLLLAPLLALLSALAAPLLFLLLGhspeVQAL 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 120 ---YLSIiaLSPAVLFTSIASAYRGYFQGWGNMTPTAISQVIEQVGNTIF--TLLFGIFlikyGL-EAGCAGATMGTSIG 193
Cdd:cd13133 123 eveYFRI--RILGAPFSLLGAALRAFFSGIGRTRVVMVANLVMVVVNIVLdyALIFGKL----GFpAMGIAGAAIATVIA 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 194 AFLSAIFLIIVYEKNKKIKipsKFKeVEIKRHTNKEIISKIVNYGIPITVCVGMTYAGDLIdLSNTMGRLivgGKLEGEA 273
Cdd:cd13133 197 EAVSLLFFLLLLFRRKNRR---RFG-LRRAWRFDRELLRRILRLGLPSGLQFFLDVGAFTV-FFLLIGRL---GTTELAA 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 274 SRLygflvkykqLINVpiaiitsLAVAILPAISSAAAIN----------DRDTVKSKIRYAFRICFLIAIPSAVGLGILS 343
Cdd:cd13133 269 TNI---------VFSI-------NSLAFLPMIGLGIAVSslvgqalgagRPDLAMRVTRRGLKLALAYMLLLGILFLLFP 332
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 344 GAIFNM-LKFGDGAYLMKYGSIVVVLMSIMQ-------IQTTILQSIGKLYTATLYAVIGIVCKIVANYFLIAIPSLNIL 415
Cdd:cd13133 333 ELLLSIfTPGADFALIAELAVPLLRFVAAYIlfdalalVFAGALRGAGDTRFVMLAELIVAWLYLLPPAYLLVVLGAGLA 412
|
410
....*....|....*.
gi 499411769 416 GAiYGSIIGYLVPILL 431
Cdd:cd13133 413 GA-WTVETVYVIVLAL 427
|
|
| MATE_like_4 |
cd13144 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
59-349 |
7.42e-05 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240549 [Multi-domain] Cd Length: 434 Bit Score: 45.30 E-value: 7.42e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 59 SGIPVAISKLISELTAVGNYKDAVKTFKIARFMLLIIGIFMTGLMLLFSAPISKG-------INQRRAYLSIIALSPAVL 131
Cdd:cd13144 61 VGTGVGVNALLSRSLGEKDQKEANKAANNGLLLALLSYLLFLLLGLFGVKPFFRLftddpeiLEYGYAYLSWCVIFSFGM 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 132 FTSIAsaYRGYFQGWGNMTPTAISQVIEQVGNTIFTLLFgIFLIKYGLEAGCAGATMGTSIGAFLSAIFLIIVYEKNKKI 211
Cdd:cd13144 141 FFQIL--CEKVLQSTGNTITPMIAQLIGAIINIILDPIL-IFGLFGFPAMGIAGAAIATVIGQILAMFLAFFFLLRKNKD 217
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 212 KIPsKFKEveikRHTNKEIISKIVNYGIPITvcvgmtyagdlidLSNTMGRLIVGG------KLEGEASRLYGFLVKYKQ 285
Cdd:cd13144 218 VQP-DLRL----FRPSLRIIKEIYAVGLPSI-------------IMQAISSVMVFGlnkilaGFGPTAVAVFGIYFKLQS 279
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 499411769 286 LINVPIAIITSlavAILPAISSAAAINDRDTVKSKIRYAFRICFLIAIPSAVGLGILSGAIFNM 349
Cdd:cd13144 280 FVFMPVFGLNN---GLIPIVAYNYGAGNKDRIREAIKYAILIAVVIMLAGGLLFQLFPDQLLGL 340
|
|
| MATE_MJ0709_like |
cd13147 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, ... |
52-426 |
1.48e-04 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, similar to Methanocaldococcus jannaschii MJ0709; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240552 [Multi-domain] Cd Length: 441 Bit Score: 44.45 E-value: 1.48e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 52 FIFVLTNSGIPVAISKLISELTAVGNYKDAVKTFKIARFMLLIIGIFMTGLMLLFSAPISKGINQRRAY-------LSII 124
Cdd:cd13147 55 MIIIGLGNGLGAGASSAISRRIGAKDKEGADNAAVHSILLGLIISIILTIVLLPFLEPILVLMGAGEVLdlavdygRIIF 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 125 ALSPAVLFTSIASayrGYFQGWGNMTPTAISQVIEQVGNTIftlLFGIFLikYGLEAGCAGATMGTSIGAFLSAIFLIIV 204
Cdd:cd13147 135 LGSIFLIFNNVAY---GILRGEGDTKRAMYAMVAGSILNII---LDPIFI--YTLGLGIAGAAWATVISMLISSLVLLYW 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 205 YEKNKKIKIPSKFKEVeikrHTNKEIISKIVNYGIPITvcvgmtyagdLIDLSNTMGRLIVGGKLEGEASRlYGFLVKYK 284
Cdd:cd13147 207 FFVKKDTYVSLSLKNF----KFDKKIVKDILKVGIPAS----------LEQLIMSVLMIILNLILVIVAGT-DGVAVYTA 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 285 QLINVPIAIITSLAVAILPAISSAAAINDRDTVKSKI--RYAFRICFLIAIPSAVGLGILSGAIF--------NMLKFGD 354
Cdd:cd13147 272 GWRIVSFAIIPLIGIATAVTSVTGAAYGARNYEKLKTayNYSIKLGLIIELIIAILIFIFAPQIAylftyseeSAHLAPE 351
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 355 GAYLMKYGSIVVVLMSIMQIQTTILQSIGK---------LYTATLYAVIGIVCKIVANYFLIAIPSLNILGAIYGSIIGY 425
Cdd:cd13147 352 IVAFLRIMCLFLPFVPFGMMSSSMFQGIGKgltsliitiLRELIFQVLFAYLFAIVLGLGLFGVWWGIVLGNAIGSIVGY 431
|
.
gi 499411769 426 L 426
Cdd:cd13147 432 L 432
|
|
| Polysacc_synt_3 |
pfam13440 |
Polysaccharide biosynthesis protein; |
34-354 |
2.44e-04 |
|
Polysaccharide biosynthesis protein;
Pssm-ID: 404342 [Multi-domain] Cd Length: 293 Bit Score: 42.97 E-value: 2.44e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 34 IITDEGYGVYGAAYSVYVFIFVLTNSGIPVAiskLISELTAVGNYKDAVKTFkiarfmLLIIGIFMTGLMLLFSAPISKG 113
Cdd:pfam13440 5 LLSPEDFGVVAIATVVISFANIFVDMGFSSA---LIQKKDITETDYSTVFTF------NLIFGALIYLILFALAPLIASF 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 114 INQRRAYLSIIALSPAVLFTSIASAYRGYFQGWGNMTPTAISQVIEQVGNTIFTLLFGifLIKYGLEAgcagATMGTSIG 193
Cdd:pfam13440 76 YNQPELVPVLRVLALVLILNGLSSVQTALLRRDLRFKKLFKITLTSSVIGGIVGIVLA--YLGFGVWA----LVIGTLAQ 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 194 AFLSAIFLIIVYekNKKIKIPSKFKeveikrhtnkeIISKIVNYGIPitvcvgMTYAGDLIDLSNTMGRLIVGGKLegeA 273
Cdd:pfam13440 150 QLLSLVLLWLAS--DWRPRLTFSLK-----------VIKELFSFGSW------LLLSNLLNYLARNLDNLIIGKVL---G 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 274 SRLYGFLVKYKQLINVPIAIITS-LAVAILPAISSAAaiNDRDTVKSKIRYAFRICFLIAIPSAVGLGILSGAIFNMLkF 352
Cdd:pfam13440 208 TAALGLYSVAYRLALLPTANITSvITKVLFPALSRIQ--DDKAKLRELYLRVLRLIAFIVFPIMAGLAVVAEPLVLVL-L 284
|
..
gi 499411769 353 GD 354
Cdd:pfam13440 285 GS 286
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
44-254 |
5.65e-04 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 42.50 E-value: 5.65e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 44 GAAYSVYVFIFVLtNSGIPVAISKLISELTAVGNYKDAVKTFKIARFMLLIIGIFMTGLMLLFSAPISKGINQR------ 117
Cdd:cd13137 40 GLATQVLWLLLVL-NMALGTGTVALVSQSYGAGDYERARRALGQSLLLALLLSLPLALLGLLFAEPLLRLLGADpevial 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 118 -RAYLSIIALSPAVLFTSIASAyrGYFQGWGNMTPTAISQVIEQVGNTIFTLLFgIFLIKYGLEAGCAGATMGTSIGAFL 196
Cdd:cd13137 119 aLTYLRIVLLGIPFFFLSLVGN--AALRGAGDTKTPMYIMIIVNVLNIVLDYVL-IFGLWGFPGLGVAGAALATVISRVV 195
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 499411769 197 SAIFLIIVYeKNKKIKIPSKFKEVEIkrhtNKEIISKIVNYGIPITVCVGMTYAGDLI 254
Cdd:cd13137 196 GALLLLFLL-LRGRLPIKISFKGFRL----DRKIIKKLLRIGLPAGLEQLLRSLGFLV 248
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
283-451 |
9.64e-04 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 41.54 E-value: 9.64e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 283 YKQLINVPIAIITSLAVAILPAISSAAAINDRDTVKSKIRYAFRICFLIAIPSAVGLGILSGAIFNMLKFGD-----GAY 357
Cdd:cd12082 36 AFPLIALLIALGVGLSVGTSALISQAIGAGDEEKARRVLVQSIVLAILLGLLLAALLLFFSPLILSLLGAEEevielAAT 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 358 LMKYGSIVVVLMSIMQIQTTILQSIGKLYTATLYAVIGIVCKIVANYFLI---AIPSLNILGAIYGSIIGYLVPILLNHR 434
Cdd:cd12082 116 YLTILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSNLLNILLDPLLIfglGPPELGIAGAALATVISYVIGALLLLI 195
|
170
....*....|....*..
gi 499411769 435 MLLKSLNIKFKLLEQAK 451
Cdd:cd12082 196 YLRKGKKILKFKLSLLK 212
|
|
| MATE_like_1 |
cd13140 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
56-210 |
1.19e-03 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240545 [Multi-domain] Cd Length: 435 Bit Score: 41.36 E-value: 1.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 56 LTNSGIPVAISKLISELTAVGNYKDAVKTFKIARFMLLIIGIFMTGLMLLFSAPI-------SKGINQRRAYLSIIALSp 128
Cdd:cd13140 281 MTAEGFSTALAAFVGQNYGAGKYDRIRKGYKTALKIASAIGLFATLLLFFFGEPLfslfipdPETIAIGVDYLRILGFS- 359
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 129 aVLFTSIASAYRGYFQGWGN-MTPTAISqvieqvgnTIFTLL---FGIFLIKYGLeaGCAGATMGTSIGAFLSAIFLIIV 204
Cdd:cd13140 360 -QLFMCLEITTTGAFNGLGRtKPPAIIS--------IVFNGLripLALLLSPTGL--GLNGIWWAISISSILKGIILTIW 428
|
....*.
gi 499411769 205 YEKNKK 210
Cdd:cd13140 429 FLLYKK 434
|
|
| RfbX |
COG2244 |
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane ... |
13-202 |
4.28e-03 |
|
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441845 [Multi-domain] Cd Length: 366 Bit Score: 39.55 E-value: 4.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 13 LSLAGMMVKVLSLLYIPFLRVIITDEGYGVYGAAYSVYVFIFVLTNSGIPVAISKlISELTAVGNYKDAVKTFKIARFML 92
Cdd:COG2244 182 LLLSGLLGLLLTNLDRLLLGALLGPAAVGIYSAAYRLASLLLLLITALSQVLFPR-LSRLLAEGDREELRRLYRKALRLL 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411769 93 LIIGIFMTGLMLLFSAPISK---GINQRRAYLSIIALSPAVLFTSIASAYRGYFQGWGNMTPTAISQVIEqvgnTIFTLL 169
Cdd:COG2244 261 LLLGLPLALGLALLAPPLLSllfGPEYAEAAPVLPILALGALFLALSGVLSNLLLALGRTRLLLIISLIG----AVLNLV 336
|
170 180 190
....*....|....*....|....*....|...
gi 499411769 170 FGIFLIKYGleaGCAGATMGTSIGAFLSAIFLI 202
Cdd:COG2244 337 LNLLLIPRY---GLVGAAIATLLSYLVLLLLLL 366
|
|
| |
