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Conserved domains on  [gi|499411837|ref|WP_011099304|]
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YlbF family regulator [Clostridium tetani]

Protein Classification

YlbF family regulator( domain architecture ID 10014326)

YlbF family regulator similar to Bacillus subtilis regulatory protein YlbF involved in competence development and sporulation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK13676 PRK13676
YlbF/YmcA family competence regulator;
1-112 9.51e-37

YlbF/YmcA family competence regulator;


:

Pssm-ID: 237467 [Multi-domain]  Cd Length: 114  Bit Score: 120.81  E-value: 9.51e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411837   1 MNLYDKAHELARVLKDCPEVVELRNTSVKMKENEDNLKMLKDFRQLQYEAYYEQLNNEKISEETETKLNKLGSIIAMNKT 80
Cdd:PRK13676   3 VNIYDLANELERALRELPEYKALKEAKEAVKADEEAKKLFDEFRALQLEIQQKQMTGQEITEEEQQKAQELGQKIQQNEL 82

                         90       100       110
                 ....*....|....*....|....*....|..
gi 499411837  81 VSNYLEAESRFAVIWEDLIKILNEAVDVDLSF 112
Cdd:PRK13676  83 LSKLMEAEQRLSVYINDINKIIFKPLEELYKD 114
 
Name Accession Description Interval E-value
PRK13676 PRK13676
YlbF/YmcA family competence regulator;
1-112 9.51e-37

YlbF/YmcA family competence regulator;


Pssm-ID: 237467 [Multi-domain]  Cd Length: 114  Bit Score: 120.81  E-value: 9.51e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411837   1 MNLYDKAHELARVLKDCPEVVELRNTSVKMKENEDNLKMLKDFRQLQYEAYYEQLNNEKISEETETKLNKLGSIIAMNKT 80
Cdd:PRK13676   3 VNIYDLANELERALRELPEYKALKEAKEAVKADEEAKKLFDEFRALQLEIQQKQMTGQEITEEEQQKAQELGQKIQQNEL 82

                         90       100       110
                 ....*....|....*....|....*....|..
gi 499411837  81 VSNYLEAESRFAVIWEDLIKILNEAVDVDLSF 112
Cdd:PRK13676  83 LSKLMEAEQRLSVYINDINKIIFKPLEELYKD 114
YlbF COG3679
Cell fate regulator YlbF, YheA/YmcA/DUF963 family (controls sporulation, competence, biofilm ...
 1-112 2.04e-24

Cell fate regulator YlbF, YheA/YmcA/DUF963 family (controls sporulation, competence, biofilm development) [Signal transduction mechanisms];


Pssm-ID: 442895 [Multi-domain]  Cd Length: 112  Bit Score: 89.51  E-value: 2.04e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411837   1 MNLYDKAHELARVLKDCPEVVELRNTSVKMKENEDNLKMLKDFRQLQYEAYYEQLNNEKISEETETKLNKLGSIIAMNKT 80
Cdd:COG3679    1 MNIYDKANELAEAIRESEEYKALKEAKEAVEADEEAQKLIREFQKLQEELQEKQRFGQEHTEEEMKKLQELKRELDLNPV 80

                         90       100       110
                 ....*....|....*....|....*....|..
gi 499411837  81 VSNYLEAESRFAVIWEDLIKILNEAVDVDLSF 112
Cdd:COG3679   81 IAEYLEAEQRLQQLLDDINKIIAEAVSEGYNP 112
Com_YlbF pfam06133
Control of competence regulator ComK, YlbF/YmcA; YlbF Is a family of short Gram-positive and ...
 5-107 2.09e-19

Control of competence regulator ComK, YlbF/YmcA; YlbF Is a family of short Gram-positive and archaeal proteins that includes both YlbF and YmcA which may interact synergistically. The family is necessary for correct biofilm formation, as null mutants of ymcA and ylbF fail to form pellicles at air-liquid interfaces and grow on solid media as smooth, undifferentiated colonies. During development, YmcA, YlbF and YaaT, family PSPI, pfam04468, interact directly with one another forming a stable ternary complex, in vitro. All three proteins are required for competence, sporulation and the formation of biofilms. The YmcA-YlbF-YaaT complex affects the phosphotransfer between Spo0F and Spo0B, thus accelerating the production of Spo0A~P. The three processes of biofilm formation, mature spore formation and competence all require the active, phosphorylated form of Spo0A, as Spo0A-P.


Pssm-ID: 428784 [Multi-domain]  Cd Length: 103  Bit Score: 76.42  E-value: 2.09e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411837    5 DKAHELARVLKDCPEVVELRNTSVKMKENEDNLKMLKDFRQLQYEAYYEQLNNEKISEETETKLNKLGSIIAMNKTVSNY 84
Cdd:pfam06133   1 DKARELAKAIKESEEYKRYKEAEEALEADEEAQKLIKEFRKLQEELQEKQMQGEELTEEEKQELQELYEELDQNPLVAEY 80

                          90       100
                  ....*....|....*....|...
gi 499411837   85 LEAESRFAVIWEDLIKILNEAVD 107
Cdd:pfam06133  81 LEAEQELNDLLQEVNKIIAEAIS 103
 
Name Accession Description Interval E-value
PRK13676 PRK13676
YlbF/YmcA family competence regulator;
1-112 9.51e-37

YlbF/YmcA family competence regulator;


Pssm-ID: 237467 [Multi-domain]  Cd Length: 114  Bit Score: 120.81  E-value: 9.51e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411837   1 MNLYDKAHELARVLKDCPEVVELRNTSVKMKENEDNLKMLKDFRQLQYEAYYEQLNNEKISEETETKLNKLGSIIAMNKT 80
Cdd:PRK13676   3 VNIYDLANELERALRELPEYKALKEAKEAVKADEEAKKLFDEFRALQLEIQQKQMTGQEITEEEQQKAQELGQKIQQNEL 82

                         90       100       110
                 ....*....|....*....|....*....|..
gi 499411837  81 VSNYLEAESRFAVIWEDLIKILNEAVDVDLSF 112
Cdd:PRK13676  83 LSKLMEAEQRLSVYINDINKIIFKPLEELYKD 114
YlbF COG3679
Cell fate regulator YlbF, YheA/YmcA/DUF963 family (controls sporulation, competence, biofilm ...
 1-112 2.04e-24

Cell fate regulator YlbF, YheA/YmcA/DUF963 family (controls sporulation, competence, biofilm development) [Signal transduction mechanisms];


Pssm-ID: 442895 [Multi-domain]  Cd Length: 112  Bit Score: 89.51  E-value: 2.04e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411837   1 MNLYDKAHELARVLKDCPEVVELRNTSVKMKENEDNLKMLKDFRQLQYEAYYEQLNNEKISEETETKLNKLGSIIAMNKT 80
Cdd:COG3679    1 MNIYDKANELAEAIRESEEYKALKEAKEAVEADEEAQKLIREFQKLQEELQEKQRFGQEHTEEEMKKLQELKRELDLNPV 80

                         90       100       110
                 ....*....|....*....|....*....|..
gi 499411837  81 VSNYLEAESRFAVIWEDLIKILNEAVDVDLSF 112
Cdd:COG3679   81 IAEYLEAEQRLQQLLDDINKIIAEAVSEGYNP 112
Com_YlbF pfam06133
Control of competence regulator ComK, YlbF/YmcA; YlbF Is a family of short Gram-positive and ...
 5-107 2.09e-19

Control of competence regulator ComK, YlbF/YmcA; YlbF Is a family of short Gram-positive and archaeal proteins that includes both YlbF and YmcA which may interact synergistically. The family is necessary for correct biofilm formation, as null mutants of ymcA and ylbF fail to form pellicles at air-liquid interfaces and grow on solid media as smooth, undifferentiated colonies. During development, YmcA, YlbF and YaaT, family PSPI, pfam04468, interact directly with one another forming a stable ternary complex, in vitro. All three proteins are required for competence, sporulation and the formation of biofilms. The YmcA-YlbF-YaaT complex affects the phosphotransfer between Spo0F and Spo0B, thus accelerating the production of Spo0A~P. The three processes of biofilm formation, mature spore formation and competence all require the active, phosphorylated form of Spo0A, as Spo0A-P.


Pssm-ID: 428784 [Multi-domain]  Cd Length: 103  Bit Score: 76.42  E-value: 2.09e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499411837    5 DKAHELARVLKDCPEVVELRNTSVKMKENEDNLKMLKDFRQLQYEAYYEQLNNEKISEETETKLNKLGSIIAMNKTVSNY 84
Cdd:pfam06133   1 DKARELAKAIKESEEYKRYKEAEEALEADEEAQKLIKEFRKLQEELQEKQMQGEELTEEEKQELQELYEELDQNPLVAEY 80

                          90       100
                  ....*....|....*....|...
gi 499411837   85 LEAESRFAVIWEDLIKILNEAVD 107
Cdd:pfam06133  81 LEAEQELNDLLQEVNKIIAEAIS 103
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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