NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|499450497|ref|WP_011137961|]
View 

MULTISPECIES: transcriptional regulator [Burkholderiales]

Protein Classification

transcriptional regulator( domain architecture ID 11486927)

helix-turn-helix-type transcriptional regulator

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PRK13890 PRK13890
conjugal transfer protein TrbA; Provisional
 1-120 1.29e-84

conjugal transfer protein TrbA; Provisional


:

Pssm-ID: 237547 [Multi-domain]  Cd Length: 120  Bit Score: 241.97  E-value: 1.29e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499450497   1 MYNYIFFTNVLRLLDERHMTKKELSNRSGVSISFLSDLTTGKANPSLKVMEDIAQALETPLPLLLESTDLDKEALDTLAG 80
Cdd:PRK13890   1 MYNYIFFTNVLRLLDERHMTKKELSERSGVSISFLSDLTTGKANPSLKVMEAIADALETPLPLLLESTDLDKEALDALAG 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 499450497  81 GKAPRSLPPGFERVAAVLPEHQAFIVKKWGEATRKKLRGS 120
Cdd:PRK13890  81 GKAPRSLPPGFERVAAVLPEHQAFIVKKWGEATRKKLRGS 120
 
Name Accession Description Interval E-value
PRK13890 PRK13890
conjugal transfer protein TrbA; Provisional
 1-120 1.29e-84

conjugal transfer protein TrbA; Provisional


Pssm-ID: 237547 [Multi-domain]  Cd Length: 120  Bit Score: 241.97  E-value: 1.29e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499450497   1 MYNYIFFTNVLRLLDERHMTKKELSNRSGVSISFLSDLTTGKANPSLKVMEDIAQALETPLPLLLESTDLDKEALDTLAG 80
Cdd:PRK13890   1 MYNYIFFTNVLRLLDERHMTKKELSERSGVSISFLSDLTTGKANPSLKVMEAIADALETPLPLLLESTDLDKEALDALAG 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 499450497  81 GKAPRSLPPGFERVAAVLPEHQAFIVKKWGEATRKKLRGS 120
Cdd:PRK13890  81 GKAPRSLPPGFERVAAVLPEHQAFIVKKWGEATRKKLRGS 120
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 12-56 1.60e-07

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 44.85  E-value: 1.60e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 499450497  12 RLLDERHMTKKELSNRSGVSISFLSDLTTGKANPSLKVMEDIAQA 56
Cdd:cd00093    6 ELRKEKGLTQEELAEKLGVSRSTISRIENGKRNPSLETLEKLAKA 50
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
12-56 3.62e-07

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 43.66  E-value: 3.62e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 499450497    12 RLLDERHMTKKELSNRSGVSISFLSDLTTGKANPSLKVMEDIAQA 56
Cdd:smart00530   4 ELREEKGLTQEELAEKLGVSRSTLSRIENGKRKPSLETLKKLAKA 48
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
12-56 4.38e-07

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 44.22  E-value: 4.38e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 499450497  12 RLLDERHMTKKELSNRSGVSISFLSDLTTGKANPSLKVMEDIAQA 56
Cdd:COG1396   14 ELRKARGLTQEELAERLGVSRSTISRIERGRRNPSLETLLKLAKA 58
KORA pfam16509
TrfB plasmid transcriptional repressor; KORA is a family of Gram-negative bacterial proteins ...
 85-108 1.57e-06

TrfB plasmid transcriptional repressor; KORA is a family of Gram-negative bacterial proteins that act as global repressors of genes involved in plasmid replication, conjugative transfer and stable inheritance in the IncP group of plasmids. KORA operates as a symmetric dimer, and contacts the DNA via the helix-turn-helix region at the N-terminus.


Pssm-ID: 435386  Cd Length: 84  Bit Score: 42.87  E-value: 1.57e-06
                          10        20
                  ....*....|....*....|....
gi 499450497   85 RSLPPGFERVAAVLPEHQAFIVKK 108
Cdd:pfam16509  61 RLEPAGWERVSVILPPEQAFIVKA 84
 
Name Accession Description Interval E-value
PRK13890 PRK13890
conjugal transfer protein TrbA; Provisional
 1-120 1.29e-84

conjugal transfer protein TrbA; Provisional


Pssm-ID: 237547 [Multi-domain]  Cd Length: 120  Bit Score: 241.97  E-value: 1.29e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499450497   1 MYNYIFFTNVLRLLDERHMTKKELSNRSGVSISFLSDLTTGKANPSLKVMEDIAQALETPLPLLLESTDLDKEALDTLAG 80
Cdd:PRK13890   1 MYNYIFFTNVLRLLDERHMTKKELSERSGVSISFLSDLTTGKANPSLKVMEAIADALETPLPLLLESTDLDKEALDALAG 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 499450497  81 GKAPRSLPPGFERVAAVLPEHQAFIVKKWGEATRKKLRGS 120
Cdd:PRK13890  81 GKAPRSLPPGFERVAAVLPEHQAFIVKKWGEATRKKLRGS 120
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 12-56 1.60e-07

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 44.85  E-value: 1.60e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 499450497  12 RLLDERHMTKKELSNRSGVSISFLSDLTTGKANPSLKVMEDIAQA 56
Cdd:cd00093    6 ELRKEKGLTQEELAEKLGVSRSTISRIENGKRNPSLETLEKLAKA 50
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
12-56 3.62e-07

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 43.66  E-value: 3.62e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 499450497    12 RLLDERHMTKKELSNRSGVSISFLSDLTTGKANPSLKVMEDIAQA 56
Cdd:smart00530   4 ELREEKGLTQEELAEKLGVSRSTLSRIENGKRKPSLETLKKLAKA 48
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
12-56 4.38e-07

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 44.22  E-value: 4.38e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 499450497  12 RLLDERHMTKKELSNRSGVSISFLSDLTTGKANPSLKVMEDIAQA 56
Cdd:COG1396   14 ELRKARGLTQEELAERLGVSRSTISRIERGRRNPSLETLLKLAKA 58
KORA pfam16509
TrfB plasmid transcriptional repressor; KORA is a family of Gram-negative bacterial proteins ...
 85-108 1.57e-06

TrfB plasmid transcriptional repressor; KORA is a family of Gram-negative bacterial proteins that act as global repressors of genes involved in plasmid replication, conjugative transfer and stable inheritance in the IncP group of plasmids. KORA operates as a symmetric dimer, and contacts the DNA via the helix-turn-helix region at the N-terminus.


Pssm-ID: 435386  Cd Length: 84  Bit Score: 42.87  E-value: 1.57e-06
                          10        20
                  ....*....|....*....|....
gi 499450497   85 RSLPPGFERVAAVLPEHQAFIVKK 108
Cdd:pfam16509  61 RLEPAGWERVSVILPPEQAFIVKA 84
HTH_3 pfam01381
Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and ...
 12-56 3.19e-06

Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteriztic of the whole family.


Pssm-ID: 460181 [Multi-domain]  Cd Length: 55  Bit Score: 41.37  E-value: 3.19e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 499450497   12 RLLDERHMTKKELSNRSGVSISFLSDLTTGKANPSLKVMEDIAQA 56
Cdd:pfam01381   3 ELREELGLSQEELAEKLGVSRSTISKIENGKREPSLETLKKLAEA 47
XRE COG1476
DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];
7-56 4.32e-06

DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];


Pssm-ID: 441085 [Multi-domain]  Cd Length: 68  Bit Score: 41.37  E-value: 4.32e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 499450497   7 FTNVLRLL-DERHMTKKELSNRSGVSISFLSDLTTGKANPSLKVMEDIAQA 56
Cdd:COG1476    5 LGNRLKELrKERGLTQEELAELLGVSRQTISAIENGKYNPSLELALKIARA 55
YozG COG3655
DNA-binding transcriptional regulator, XRE family [Transcription];
9-56 1.01e-05

DNA-binding transcriptional regulator, XRE family [Transcription];


Pssm-ID: 442872 [Multi-domain]  Cd Length: 69  Bit Score: 40.51  E-value: 1.01e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 499450497   9 NVLRLLDERHMTKKELSNRSGVSISFLSDLTTGKA-NPSLKVMEDIAQA 56
Cdd:COG3655    5 KLDELLAERGMTKKELAEATGISRATLSRLKNGKAkAVRLDTLEKICKA 53
HTH_26 pfam13443
Cro/C1-type HTH DNA-binding domain; This is a helix-turn-helix domain that probably binds to ...
 9-56 1.87e-05

Cro/C1-type HTH DNA-binding domain; This is a helix-turn-helix domain that probably binds to DNA.


Pssm-ID: 433211 [Multi-domain]  Cd Length: 63  Bit Score: 39.45  E-value: 1.87e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 499450497    9 NVLRLLDERHMTKKELSNRSGVSISFLSDLTTGKA-NPSLKVMEDIAQA 56
Cdd:pfam13443   1 KLRKLMADRGISKSDLARATGISRATLSRLRKGKPkRVSLDTLDKICDA 49
PRK08154 PRK08154
anaerobic benzoate catabolism transcriptional regulator; Reviewed
 10-57 3.82e-05

anaerobic benzoate catabolism transcriptional regulator; Reviewed


Pssm-ID: 236167 [Multi-domain]  Cd Length: 309  Bit Score: 41.09  E-value: 3.82e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 499450497  10 VLRLLDERHMTKKELSNRSGVSISFLSDLTTGKANPSLKVMEDIAQAL 57
Cdd:PRK08154  33 VRTLRARRGMSRKVLAQASGVSERYLAQLESGQGNVSILLLRRVARAL 80
AF2118 COG3620
Predicted transcriptional regulator, contains an XRE-type HTH domain (archaeal members contain ...
 10-56 6.47e-05

Predicted transcriptional regulator, contains an XRE-type HTH domain (archaeal members contain CBS pair) [Transcription];


Pssm-ID: 442838 [Multi-domain]  Cd Length: 95  Bit Score: 38.85  E-value: 6.47e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 499450497  10 VLRLLDERHMTKKELSNRSGVSISFLSDLTTGKANPSLKVMEDIAQA 56
Cdd:COG3620   22 LRLMRKELGLSQLPVAELVGVSQSDILRIESGKRDPTVSTLEKIAEA 68
aMBF1 COG1813
Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and ...
 16-56 2.05e-04

Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and HTH domains [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441418 [Multi-domain]  Cd Length: 70  Bit Score: 36.84  E-value: 2.05e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 499450497  16 ERHMTKKELSNRSGVSISFLSDLTTGKANPSLKVMEDIAQA 56
Cdd:COG1813   23 ARGLSQEELAEKLGVSESTIRRIERGEATPSLDTLRKLEKA 63
VapI COG3093
Plasmid maintenance system antidote protein VapI, contains XRE-type HTH domain [Defense ...
 1-56 2.70e-03

Plasmid maintenance system antidote protein VapI, contains XRE-type HTH domain [Defense mechanisms];


Pssm-ID: 442327 [Multi-domain]  Cd Length: 87  Bit Score: 34.40  E-value: 2.70e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 499450497   1 MYNYIFFTNVLR--LLDERHMTKKELSNRSGVSISFLSDLTTGKANPSLKVMEDIAQA 56
Cdd:COG3093    3 KRNPIHPGEILReeFLEPLGLSQTELAKALGVSRQRISEILNGKRAITADTALRLARA 60
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH