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Conserved domains on  [gi|499475433|ref|WP_011162073|]
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nitroreductase family protein [Lactobacillus johnsonii]

Protein Classification

nitroreductase family protein( domain architecture ID 10002498)

nitroreductase family protein may catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor

CATH:  3.40.109.10|2.20.180.10
EC:  1.-.-.-
Gene Ontology:  GO:0016491
PubMed:  29078300|7601851
SCOP:  3001947

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NfnB COG0778
Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway ...
 1-152 1.31e-31

Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway/BioSystem: Pyrimidine degradation


:

Pssm-ID: 440541 [Multi-domain]  Cd Length: 163  Bit Score: 111.10  E-value: 1.31e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499475433   1 MNAIFEREAVRKYTDEKIDEEKIQKLINAFQASPCAMHQTDVmELSVITSPELLKKIED---NTNNS-CYNAPLIFMI-- 74
Cdd:COG0778    2 LELLLTRRSVRKFTDKPVSDEELEELLEAARLAPSAGNLQPW-RFVVVRDPELRERLAEalaEANQEwVADAPVLIVVca 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499475433  75 ----NTKKDSQFGERDASVAAENVMVEAADLGLGSVYvMGGVFAlnkfPELQKELGMDEGYEPTVLVPIGYPADKEQVED 150
Cdd:COG0778   81 dpdrSEKVPERYALLDAGIAAQNLLLAARALGLGTCW-IGGFDP----EKVRELLGLPEGEEPVALLALGYPAEELNPRP 155


                 ..
gi 499475433 151 RR 152
Cdd:COG0778  156 RK 157
 
Name Accession Description Interval E-value
NfnB COG0778
Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway ...
 1-152 1.31e-31

Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 440541 [Multi-domain]  Cd Length: 163  Bit Score: 111.10  E-value: 1.31e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499475433   1 MNAIFEREAVRKYTDEKIDEEKIQKLINAFQASPCAMHQTDVmELSVITSPELLKKIED---NTNNS-CYNAPLIFMI-- 74
Cdd:COG0778    2 LELLLTRRSVRKFTDKPVSDEELEELLEAARLAPSAGNLQPW-RFVVVRDPELRERLAEalaEANQEwVADAPVLIVVca 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499475433  75 ----NTKKDSQFGERDASVAAENVMVEAADLGLGSVYvMGGVFAlnkfPELQKELGMDEGYEPTVLVPIGYPADKEQVED 150
Cdd:COG0778   81 dpdrSEKVPERYALLDAGIAAQNLLLAARALGLGTCW-IGGFDP----EKVRELLGLPEGEEPVALLALGYPAEELNPRP 155


                 ..
gi 499475433 151 RR 152
Cdd:COG0778  156 RK 157
Nitro_FMN_reductase cd02062
nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or ...
 4-141 3.01e-29

nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are described as NAD(P)H:FMN oxidoreductases, oxygen-insensitive nitroreductase, flavin reductase P, dihydropteridine reductase, NADH oxidase or NADH dehydrogenase.


Pssm-ID: 380311 [Multi-domain]  Cd Length: 139  Bit Score: 104.30  E-value: 3.01e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499475433   4 IFEREAVRKYTDEKIDEEKIQKLINAFQASPCAMHQTDVmELSVITSPELLKKIEDNT---NNSCYNAP--LIFMINTKK 78
Cdd:cd02062    1 IKTRRSIRKFTDKPVPEEKLRKILEAARLAPSAGNLQPW-RFIVVRDREKKEKLAKLAapnQKFIAGAPvvIVVVADPDK 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 499475433  79 DSQFGERDASVAAENVMVEAADLGLGSVYVMGGvfaLNKFPELQKELGMDEGYEPTVLVPIGY 141
Cdd:cd02062   80 SRPWALEDAGAAAQNLLLAAAALGLGSCWIGGF---DFREDKVRELLGIPENLRPVALIAIGY 139
Nitroreductase pfam00881
Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent ...
 4-141 7.90e-19

Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent and NAD(P)H-dependent enzymes able to metabolize nitrosubstituted compounds.


Pssm-ID: 425926 [Multi-domain]  Cd Length: 168  Bit Score: 78.20  E-value: 7.90e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499475433    4 IFEREAVRKYTDEKIDEEKIQKLINAFQASPCAMHQTDVmELSVITSPELLKKIED------------------------ 59
Cdd:pfam00881   1 IRQRRSVRKFDPEPVPKEVLEEILEAARRAPSAGNLQPW-RFYVVTDGELRYRLAEaalelllvepaaalllllrrdanl 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499475433   60 --NTNNSCYNAPLIFMI----------NTKKDSQFGERDASVAAENVMVEAADLGLGSVYvMGGVfalnKFPELQKELGM 127
Cdd:pfam00881  80 klLLQDFLRGAPVLIVItaslstylrkAAERAYREALLDAGAAAQNLLLAATSLGLGSCP-IGGF----DAAAVRELLGL 154

                         170
                  ....*....|....
gi 499475433  128 DEGYEPTVLVPIGY 141
Cdd:pfam00881 155 PDDERLVGLIAVGY 168
PRK10765 PRK10765
oxygen-insensitive NADPH nitroreductase;
2-156 3.87e-09

oxygen-insensitive NADPH nitroreductase;


Pssm-ID: 182710  Cd Length: 240  Bit Score: 53.44  E-value: 3.87e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499475433   2 NAIFEREAVRKYTDEKIDEEKIQKLINAFQASPCAMHQTDVmelSVI--TSPELLKKIEDNTNNSCY--NAP--LIFMIN 75
Cdd:PRK10765   6 ELILSHRSIRHFTDEPISEAQREAIINAARAASSSSFLQCS---SIIriTDKALREALVELTGGQKYvaQAAefWVFCAD 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499475433  76 TKK------DSQ--FGER------DASVAAENVMVEAADLGLGSVYVmGGVfaLNKFPELQKELGMDEGYEPTVLVPIGY 141
Cdd:PRK10765  83 FNRhlqicpDAQlgLAEQlligavDTAIMAQNALLAAESLGLGGVYI-GGL--RNNIEAVTELLKLPQHVLPLFGLCLGW 159

                        170       180
                 ....*....|....*....|...
gi 499475433 142 PADKEQVEDR--------RNRYK 156
Cdd:PRK10765 160 PAQNPDLKPRlpasllvhENQYQ 182
 
Name Accession Description Interval E-value
NfnB COG0778
Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway ...
 1-152 1.31e-31

Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 440541 [Multi-domain]  Cd Length: 163  Bit Score: 111.10  E-value: 1.31e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499475433   1 MNAIFEREAVRKYTDEKIDEEKIQKLINAFQASPCAMHQTDVmELSVITSPELLKKIED---NTNNS-CYNAPLIFMI-- 74
Cdd:COG0778    2 LELLLTRRSVRKFTDKPVSDEELEELLEAARLAPSAGNLQPW-RFVVVRDPELRERLAEalaEANQEwVADAPVLIVVca 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499475433  75 ----NTKKDSQFGERDASVAAENVMVEAADLGLGSVYvMGGVFAlnkfPELQKELGMDEGYEPTVLVPIGYPADKEQVED 150
Cdd:COG0778   81 dpdrSEKVPERYALLDAGIAAQNLLLAARALGLGTCW-IGGFDP----EKVRELLGLPEGEEPVALLALGYPAEELNPRP 155


                 ..
gi 499475433 151 RR 152
Cdd:COG0778  156 RK 157
Nitro_FMN_reductase cd02062
nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or ...
 4-141 3.01e-29

nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are described as NAD(P)H:FMN oxidoreductases, oxygen-insensitive nitroreductase, flavin reductase P, dihydropteridine reductase, NADH oxidase or NADH dehydrogenase.


Pssm-ID: 380311 [Multi-domain]  Cd Length: 139  Bit Score: 104.30  E-value: 3.01e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499475433   4 IFEREAVRKYTDEKIDEEKIQKLINAFQASPCAMHQTDVmELSVITSPELLKKIEDNT---NNSCYNAP--LIFMINTKK 78
Cdd:cd02062    1 IKTRRSIRKFTDKPVPEEKLRKILEAARLAPSAGNLQPW-RFIVVRDREKKEKLAKLAapnQKFIAGAPvvIVVVADPDK 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 499475433  79 DSQFGERDASVAAENVMVEAADLGLGSVYVMGGvfaLNKFPELQKELGMDEGYEPTVLVPIGY 141
Cdd:cd02062   80 SRPWALEDAGAAAQNLLLAAAALGLGSCWIGGF---DFREDKVRELLGIPENLRPVALIAIGY 139
nitroreductase cd20609
nitroreductase family protein; A subfamily of the nitroreductase family containing ...
 1-141 4.55e-29

nitroreductase family protein; A subfamily of the nitroreductase family containing uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.often found to be homodimers.


Pssm-ID: 380330 [Multi-domain]  Cd Length: 145  Bit Score: 104.01  E-value: 4.55e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499475433   1 MNAIFEREAVRKYTDEKIDEEKIQKLINAFQASPCAM-HQTdvMELSVITSPELLKKIEDNTNNsCYNAPLIFMI----- 74
Cdd:cd20609    3 LELAKKRYSVRKFSDKPVEKEKLDKILEAGRLAPTAVnYQP--QRILVVRSEEALEKLAKATPR-FFGAPLVIVVcydkd 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 499475433  75 ------NTKKDSqfGERDASVAAENVMVEAADLGLGSVYVmgGVFALNKfpeLQKELGMDEGYEPTVLVPIGY 141
Cdd:cd20609   80 eswkrpYDGKDS--GDIDAAIVATHMMLAATELGLGTCWV--GNFDPEK---VREAFNLPENLEPVAILPLGY 145
nitroreductase cd02150
nitroreductase family protein; A subfamily of the nitroreductase family containing ...
 4-151 1.44e-28

nitroreductase family protein; A subfamily of the nitroreductase family containing uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.often found to be homodimers.


Pssm-ID: 380325 [Multi-domain]  Cd Length: 156  Bit Score: 103.06  E-value: 1.44e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499475433   4 IFEREAVRKYTDEKIDEEKIQKLINAFQASPCAMHQTDvMELSVITSPELLKKIEDNT--NNSCYNAPLIFMI----NTK 77
Cdd:cd02150    1 ILTRRSIRKYTDKPVEEEDIEKLLRAAMAAPSAGNQQP-WHFIVVTDREKLDKIAEAHpyGKMLKEAPLAIVVcgdpSKE 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 499475433  78 KDSQFGERDASVAAENVMVEAADLGLGSVYVmggvfALNKFPE----LQKELGMDEGYEPTVLVPIGYPADKEQVEDR 151
Cdd:cd02150   80 KAPGYWVQDCSAATENILLAAHALGLGAVWL-----GVYPFEErvkaIREILNIPENIIPFCVIALGYPAEEKEPKDR 152
nitroreductase cd02151
nitroreductase family protein; A subfamily of the nitroreductase family containing ...
 2-145 5.75e-22

nitroreductase family protein; A subfamily of the nitroreductase family containing uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.often found to be homodimers..


Pssm-ID: 380326 [Multi-domain]  Cd Length: 157  Bit Score: 86.05  E-value: 5.75e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499475433   2 NAIFEREAVRKYTDEKIDEEKIQKLINAFQASPCAMHQTDVmELSVITSPELLKKIEDNTN---NSCYNAPL--IFMINT 76
Cdd:cd02151    1 ELLKKRRSIRKYTDEPIEEEKLEEILEAALLAPSSRNSRPV-EFIVVDDKETLKKLSECKPhgsAFLKGAPAaiVVLADT 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 499475433  77 KKDSQFGErDASVAAENVMVEAADLGLGS--VYVMGGVFALNKFPE--LQKELGMDEGYEPTVLVPIGYPADK 145
Cdd:cd02151   80 EKSDTWIE-DASIAATYIQLAAESLGLGScwIQIRNRETQDGKTAEeyVRELLGIPENYRVLCIIALGYPDEE 151
PnbA_NfnB-like cd02136
nitroreductase similar to Mycobacterium smegmatis NfnB; Members of this family utilize FMN as ...
 3-160 1.15e-19

nitroreductase similar to Mycobacterium smegmatis NfnB; Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source of reducing equivalents in an obligatory two-election transfer mechanism. The enzyme is typically a homodimer. Mycobacterium smegmatis nitroreductase NfnB plays a role in resistance to benzothiazinone.


Pssm-ID: 380313 [Multi-domain]  Cd Length: 152  Bit Score: 79.94  E-value: 1.15e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499475433   3 AIFEREAVRKYTDEKIDEEKIQKLINAFQASPCAM-HQTdvMELSVITSP--ELLKKIEdntnnscYNAP-LIFMINTKK 78
Cdd:cd02136    1 AIKSRRSVRAFKDKPVPKETIEKILEAARRAPSGKnTQP--WRVYVVTGKarERLKKAF-------FGAPvALFLTMDKV 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499475433  79 DSQFGERDASVAAENVMVEAADLGLGSVYVmgGVFAlnKFPE-LQKELGMDEGYEPTVLVPIGYPADKEQVedrrNRYKV 157
Cdd:cd02136   72 LGPWSWFDLGAFLQNLMLAAHALGLGTCPQ--GALA--GYPDvVRKELGIPDDEELVCGIALGYPDPDAPV----NQFRT 143


                 ...
gi 499475433 158 VRK 160
Cdd:cd02136  144 PRE 146
Nitroreductase pfam00881
Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent ...
 4-141 7.90e-19

Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent and NAD(P)H-dependent enzymes able to metabolize nitrosubstituted compounds.


Pssm-ID: 425926 [Multi-domain]  Cd Length: 168  Bit Score: 78.20  E-value: 7.90e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499475433    4 IFEREAVRKYTDEKIDEEKIQKLINAFQASPCAMHQTDVmELSVITSPELLKKIED------------------------ 59
Cdd:pfam00881   1 IRQRRSVRKFDPEPVPKEVLEEILEAARRAPSAGNLQPW-RFYVVTDGELRYRLAEaalelllvepaaalllllrrdanl 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499475433   60 --NTNNSCYNAPLIFMI----------NTKKDSQFGERDASVAAENVMVEAADLGLGSVYvMGGVfalnKFPELQKELGM 127
Cdd:pfam00881  80 klLLQDFLRGAPVLIVItaslstylrkAAERAYREALLDAGAAAQNLLLAATSLGLGSCP-IGGF----DAAAVRELLGL 154

                         170
                  ....*....|....
gi 499475433  128 DEGYEPTVLVPIGY 141
Cdd:pfam00881 155 PDDERLVGLIAVGY 168
nitroreductase cd20608
nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or ...
 1-141 1.55e-18

nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are described as NAD(P)H:FMN oxidoreductases, oxygen-insensitive nitroreductase, flavin reductase P, dihydropteridine reductase, NADH oxidase or NADH dehydrogenase.


Pssm-ID: 380329 [Multi-domain]  Cd Length: 145  Bit Score: 76.99  E-value: 1.55e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499475433   1 MNAIFEREAVRKYTDEKIDEEKIQKLINAFQASPCAMHqTDVMELSVITSPELLK---KIEDNTNNSCYNAPLIFMINTK 77
Cdd:cd20608    1 FEAIKTRRSVRRFSDKPVEEEKLEKILEAARLAPSWAN-KQCWRFIVVTDKETLSelaKKESPSNGWLKDAPVIIVVCAD 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 499475433  78 -KDSqfGER--------DASVAAENVMVEAADLGLGSVYVmgGVFALNKFPELqkeLGMDEGYEPTVLVPIGY 141
Cdd:cd20608   80 pKDS--GWLngqnyylvDAAIAMQNLMLAATDLGLGTCWI--GAFDEKKVKEI---LGIPENIRVVALTPLGY 145
NfsA-like cd02146
nitroreductase similar to Escherichia coli NfsA; This family contains NADPH-dependent flavin ...
 10-156 1.75e-18

nitroreductase similar to Escherichia coli NfsA; This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as an electron donor. Oxygen-insensitive nitroreductase, such as NfsA protein in Escherichia coli, catalyzes reduction of nitrocompounds using NADPH as electron donor.


Pssm-ID: 380322 [Multi-domain]  Cd Length: 229  Bit Score: 78.82  E-value: 1.75e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499475433  10 VRKYTDEKIDEEKIQKLINAFQASPCA--MHQTDVMelsVITSPELLKKIEDNTNNSCY--NAP--LIFMINTKKDSQFG 83
Cdd:cd02146   11 VRKFTDEPLTDETLETLIAAAQSASTSsnLQAYSVI---VVTDPELREKLAELAGNQPYvaQAPvfLVFCADLYRHQKIA 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499475433  84 ER-------------------DASVAAENVMVEAADLGLGSVYVmGGVfaLNKFPELQKELGMDEGYEPTVLVPIGYPAD 144
Cdd:cd02146   88 EEaggkdvgldylesflvgvvDAALAAQNALVAAESLGLGIVYI-GGI--RNNPEEVIELLGLPEYVFPLFGLTVGHPDP 164

                        170       180
                 ....*....|....*....|
gi 499475433 145 KEQVEDR--------RNRYK 156
Cdd:cd02146  165 TPEVKPRlpleavvhEETYQ 184
MhqN-like cd02137
nitroreductase family protein similar to the NAD(P)H nitroreductase MhqN; A diverse subfamily ...
 1-145 1.51e-15

nitroreductase family protein similar to the NAD(P)H nitroreductase MhqN; A diverse subfamily of the nitroreductase family containing uncharacterized proteins; includes nitroreductases MhqN, YodC, YdgI, DrgA. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.


Pssm-ID: 380314 [Multi-domain]  Cd Length: 147  Bit Score: 69.19  E-value: 1.51e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499475433   1 MNAIFEREAVRKYTDE-KIDEEKIQKLINAFQASPCAmHQTDVMELSVITSPELLKKIEDNtnnsCYN------APLIFM 73
Cdd:cd02137    1 LEVIKSRRSVRNFDPDhKIPKEELKEILELATLAPSS-FNLQPWRFVVVRDPELKAKLAEA----AYNqpqvttASAVIL 75

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 499475433  74 IntkkdsqFGERDASVAAENVMVEAADLGLGSVyVMGGVfalnKFPELQKELGMDEGYEPTVLVPIGYPADK 145
Cdd:cd02137   76 V-------LGDLNAGLAAMNLMLAAKAKGYDTC-PMGGF----DKEKVAELLNLPDRYVPVLLIAIGKAADK 135
nitroreductase cd02139
nitroreductase family protein; A subfamily of the nitroreductase family containing ...
 1-145 6.83e-14

nitroreductase family protein; A subfamily of the nitroreductase family containing uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.


Pssm-ID: 380316 [Multi-domain]  Cd Length: 165  Bit Score: 65.18  E-value: 6.83e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499475433   1 MNAIFEREAVRKYTDEKIDEEKIQKLINAFQASPCAMHQTD---VmelsVITSPELLKKIED--NTNNSCYNAPLI---- 71
Cdd:cd02139    2 YEAIKKRRSIRKYKPTPVEEEKLLRILEAARLAPSAKNRQPwrfI----VVKDKELKEKLAEaaNGQKFIAEAPVVivac 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499475433  72 ------FMINTKKDSQFgerDASVAAENVMVEAADLGLGSVYVmgGVFalnKFPELQKELGMDEGYEPTVLVPIGYPADK 145
Cdd:cd02139   78 adpsesGMGCGKPYYLV---DVAIAMEHLVLAATEEGLGTCWI--GAF---DEDKVKEILGIPEEYRVVALTPLGYPAEE 149
nitroreductase cd20610
nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or ...
 4-141 1.05e-11

nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are described as NAD(P)H:FMN oxidoreductases, oxygen-insensitive nitroreductase, flavin reductase P, dihydropteridine reductase, NADH oxidase or NADH dehydrogenase.


Pssm-ID: 380331 [Multi-domain]  Cd Length: 167  Bit Score: 59.60  E-value: 1.05e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499475433   4 IFEREAVRKYTDEKIDEEKIQKLINAFQASPCAMHQTDvMELSVITSPELLKKIEDNTNNSCY----------------- 66
Cdd:cd20610    1 IKKRRSIRKFKPDPVPKEDIEKILEAANWAPSGMNRQN-WEFVVVKGGEKIEKIGISIKKKNEeiarllekvfaekpirf 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499475433  67 -----------NAPLIFMINTKKDSQFGERDA---SVAA--ENVMVEAADLGLGSVYVMGGVFALNkfpELQKELGMDEG 130
Cdd:cd20610   80 rkfrrfftlfgGAPVLVVVYTEPYKPPEERKPdlqSVSAaiQNLLLAAHALGLGTCWMTGPLYAED---EIEEILEIPDD 156

                        170
                 ....*....|.
gi 499475433 131 YEPTVLVPIGY 141
Cdd:cd20610  157 KELVAVTPLGY 167
TdsD-like cd02138
nitroreductase similar to Burkholderia pseudomallei TdsD; A subfamily of the nitroreductase ...
 3-147 2.85e-11

nitroreductase similar to Burkholderia pseudomallei TdsD; A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to Burkholderia pseudomallei TdsD, may be involved in the processing of organosulfur compounds. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.


Pssm-ID: 380315 [Multi-domain]  Cd Length: 174  Bit Score: 58.32  E-value: 2.85e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499475433   3 AIFEREAVRKYTDEKIDEEKIQKLINAFQASPCAM-HQtdvmelsvitsP----------ELLKKIEDN---TNNS-CYN 67
Cdd:cd02138    1 LIAERWSPRAFSPEPISEEDLLSLFEAARWAPSCFnEQ-----------PwrfvvarrdtEAFEKLLDLlaeGNQSwAKN 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499475433  68 AP-LIFMI-NTKKDSQFGER-----DASVAAENVMVEAADLGLgsvYV--MGGVFAlnkfPELQKELGMDEGYEPTVLVP 138
Cdd:cd02138   70 APvLIVVLaKTEFDHNGKPNryalfDTGAAVANLALQATALGL---VVhqMAGFDP----EKAKEALGIPDEYEPITMIA 142


                 ....*....
gi 499475433 139 IGYPADKEQ 147
Cdd:cd02138  143 IGYPGDPES 151
nitroreductase_FeS-like cd02143
nitroreductases with an N-terminal iron-sulfur cluster-binding domain; Members of this family ...
 7-143 4.01e-10

nitroreductases with an N-terminal iron-sulfur cluster-binding domain; Members of this family utilize FMN as a cofactor. This family may be involved in the reduction of flavin or nitroaromatic compounds via an obligatory two-electron transfer. Nitroreductase is homodimer. Each subunit contains one FMN molecule.


Pssm-ID: 380319 [Multi-domain]  Cd Length: 187  Bit Score: 55.56  E-value: 4.01e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499475433   7 REAVRKYTDEKIDEEKIQKLINAFQASPCAMHQTDVmELSVITSPELLKKI------------EDNTNNS---------- 64
Cdd:cd02143    5 RRSIRRYKDKPVPRETLEKLLDIARYAPTGHNSQPV-HWLVVDDPEKVRRLaelvidwmreliKEDPELAgklfldgiva 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499475433  65 ---------CYNAP-LIFMInTKKDSQFGERDASVAAENVMVEAADLGLGSV---YVMggvFALNKFPELQKELGMDEGY 131
Cdd:cd02143   84 awekgidviLRGAPhLVVAH-APKDAPTPPVDCAIALTYLELAAPSLGLGTCwagFFT---AAANNYPPLREALGLPEGH 159

                        170
                 ....*....|..
gi 499475433 132 EPTVLVPIGYPA 143
Cdd:cd02143  160 KVGGAMMLGYPK 171
PRK10765 PRK10765
oxygen-insensitive NADPH nitroreductase;
2-156 3.87e-09

oxygen-insensitive NADPH nitroreductase;


Pssm-ID: 182710  Cd Length: 240  Bit Score: 53.44  E-value: 3.87e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499475433   2 NAIFEREAVRKYTDEKIDEEKIQKLINAFQASPCAMHQTDVmelSVI--TSPELLKKIEDNTNNSCY--NAP--LIFMIN 75
Cdd:PRK10765   6 ELILSHRSIRHFTDEPISEAQREAIINAARAASSSSFLQCS---SIIriTDKALREALVELTGGQKYvaQAAefWVFCAD 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499475433  76 TKK------DSQ--FGER------DASVAAENVMVEAADLGLGSVYVmGGVfaLNKFPELQKELGMDEGYEPTVLVPIGY 141
Cdd:PRK10765  83 FNRhlqicpDAQlgLAEQlligavDTAIMAQNALLAAESLGLGGVYI-GGL--RNNIEAVTELLKLPQHVLPLFGLCLGW 159

                        170       180
                 ....*....|....*....|...
gi 499475433 142 PADKEQVEDR--------RNRYK 156
Cdd:PRK10765 160 PAQNPDLKPRlpasllvhENQYQ 182
TM1586_NiRdase pfam14512
Putative TM nitroreductase; Compared with the more traditional NADH oxidase/flavin reductase ...
 3-145 9.88e-07

Putative TM nitroreductase; Compared with the more traditional NADH oxidase/flavin reductase family, this family is a duplication, consisting of two similar domains arranged as the subunits of the dimeric NADH oxidase/flavin reductase with one conserved active site.


Pssm-ID: 405236 [Multi-domain]  Cd Length: 214  Bit Score: 46.52  E-value: 9.88e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499475433    3 AIFEREAVRKYTDEKIDEEKIQKLINAFQaspcamhqtDVMELSVItspELLKKIEDNTNNSCYNAPLIF--------MI 74
Cdd:pfam14512   5 AIFKRHSVRKYTDEPIPEELLEELKNAID---------EINKLSGL---NIQLVIDDPDAFKGKAKYGKFkgvpnyiaAY 72

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 499475433   75 NTKKDSQfgERDASVAAENVMVEAADLGLGSVYVmGGVFALNKFPELQKelgmdEGYEPTVLVPIGYPADK 145
Cdd:pfam14512  73 GEKDDDL--LENAGYYGEQIVLYATALGLGTCWV-GGTYSKSKVKAKIK-----KGEKLVIVIAFGYGATK 135
iodotyrosine_dehalogenase cd02144
iodotyrosine dehalogenase; Iodotyrosine dehalogenase catalyzes the removal of iodine from the ...
 7-150 1.28e-05

iodotyrosine dehalogenase; Iodotyrosine dehalogenase catalyzes the removal of iodine from the 3, 5 positions of L-tyosine in thyroid, liver and kidney, using NADPH as electron donor. This enzyme is a homolog of the nitroreductase family. These enzymes are usually homodimers.


Pssm-ID: 380320  Cd Length: 192  Bit Score: 43.29  E-value: 1.28e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499475433   7 REAVRKYTDEKIDEEKIQKLINAFQASPCAMHQ---TDVmelsVITSPELLKKIED------------------------ 59
Cdd:cd02144    8 RRSVRDFSSEPVPREVIENAIRTAGTAPSGANTqpwTFV----VVSDPEIKRKIREaaeeeekefyekrmgeewvwdlkp 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499475433  60 -NTN-NSCY--NAP---LIF-------MINTKKDSQFGERDASVAA-------ENVmveaadlGLGSV--YVMGGVFaln 116
Cdd:cd02144   84 lGTNwEKPYltEAPyliVVFkqkygvlPDGKKKKHYYNEESVGIAVgillaalHNA-------GLVTLthTPSPMPF--- 153

                        170       180       190
                 ....*....|....*....|....*....|....
gi 499475433 117 kfpeLQKELGMDEGYEPTVLVPIGYPADKEQVED 150
Cdd:cd02144  154 ----LRDLLGRPKNEKPLLLLPVGYPAEDATVPD 183
FbiB_C-like cd20607
nitroreductase family domain similar to the C-terminal domain of F420:gamma-glutamyl ligase ...
 90-143 1.77e-04

nitroreductase family domain similar to the C-terminal domain of F420:gamma-glutamyl ligase FbiB; Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Mycobacterium tuberculosis FbiB, is a two-domain protein and produces F420 with predominantly 5 to 7 L-glutamate residues in the poly-gamma-glutamate tail, its C-terminal domain is homologous to FMN-dependent nitroreductases.


Pssm-ID: 380328 [Multi-domain]  Cd Length: 155  Bit Score: 39.76  E-value: 1.77e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 499475433  90 AAENVMVEAADLGLGSVYVMGGVFAlnkfPEL-QKELGMDEGYEPTVLVPIGYPA 143
Cdd:cd20607   92 AVQALLVALAVRGLGSCWIGSTIFA----PDVvRDELDLPDDWEPLGAIAIGYPL 142
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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