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Conserved domains on  [gi|499508445|ref|WP_011195085|]
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PTS lactose/cellobiose transporter subunit IIA [Symbiobacterium thermophilum]

Protein Classification

PTS lactose/cellobiose transporter subunit IIA( domain architecture ID 10003680)

PTS lactose/cellobiose transporter subunit IIA helps catalyze the phosphorylation of incoming sugar substrates leading to their translocation across the cell membrane

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CelC COG1447
Phosphotransferase system cellobiose-specific component IIA [Carbohydrate transport and ...
 8-107 7.04e-28

Phosphotransferase system cellobiose-specific component IIA [Carbohydrate transport and metabolism];


:

Pssm-ID: 441056  Cd Length: 100  Bit Score: 97.52  E-value: 7.04e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499508445   8 NLIAMRIILDAGDARDFVTKAFEAMGQRDFESADEHLRAAFEKLKSAHRQQTEVIQHEVAAGSLPPSLLFNHAQDTLMVV 87
Cdd:COG1447    1 EEIAMEIILHAGNARSLAMEALKAAKEGDFEEAEELLKEADEELLEAHKVQTELIQKEAGGEKVEVSLLLVHAQDHLMTA 80

                         90       100
                 ....*....|....*....|
gi 499508445  88 GSELNLARSLLAIFINIDRR 107
Cdd:COG1447   81 MTEKDLAKELIELYKKLEKL 100
 
Name Accession Description Interval E-value
CelC COG1447
Phosphotransferase system cellobiose-specific component IIA [Carbohydrate transport and ...
 8-107 7.04e-28

Phosphotransferase system cellobiose-specific component IIA [Carbohydrate transport and metabolism];


Pssm-ID: 441056  Cd Length: 100  Bit Score: 97.52  E-value: 7.04e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499508445   8 NLIAMRIILDAGDARDFVTKAFEAMGQRDFESADEHLRAAFEKLKSAHRQQTEVIQHEVAAGSLPPSLLFNHAQDTLMVV 87
Cdd:COG1447    1 EEIAMEIILHAGNARSLAMEALKAAKEGDFEEAEELLKEADEELLEAHKVQTELIQKEAGGEKVEVSLLLVHAQDHLMTA 80

                         90       100
                 ....*....|....*....|
gi 499508445  88 GSELNLARSLLAIFINIDRR 107
Cdd:COG1447   81 MTEKDLAKELIELYKKLEKL 100
PTS_IIA pfam02255
PTS system, Lactose/Cellobiose specific IIA subunit; The bacterial phosphoenolpyruvate: sugar ...
 9-101 1.10e-27

PTS system, Lactose/Cellobiose specific IIA subunit; The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. The lactose/cellobiose-specific family are one of four structurally and functionally distinct group IIA PTS system enzymes. This family of proteins normally function as a homotrimer, stabilized by a centrally located metal ion. Separation into subunits is thought to occur after phosphorylation.


Pssm-ID: 460510  Cd Length: 94  Bit Score: 97.12  E-value: 1.10e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499508445    9 LIAMRIILDAGDARDFVTKAFEAMGQRDFESADEHLRAAFEKLKSAHRQQTEVIQHEVAAGSLPPSLLFNHAQDTLMVVG 88
Cdd:pfam02255   1 EIAMEIILHAGNARSLAMEALKAAKEGDFEEAEELLKEADEELLEAHKAQTELIQKEAGGEKVEVSLLLVHAQDHLMTAM 80

                          90
                  ....*....|...
gi 499508445   89 SELNLARSLLAIF 101
Cdd:pfam02255  81 TEKDLAKELIELY 93
PTS_IIA_lac cd00215
PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial ...
 7-101 1.22e-20

PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four structurally and functionally distinct group IIA PTS system cytoplasmic enzymes, necessary for the uptake of carbohydrates across the cytoplasmic membrane and their phosphorylation. This family of proteins normally function as a homotrimer, stabilized by a centrally located metal ion. Separation into subunits is thought to occur after phosphorylation.


Pssm-ID: 238133  Cd Length: 97  Bit Score: 79.17  E-value: 1.22e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499508445   7 LNLIAMRIILDAGDARDFVTKAFEAMGQRDFESADEHLRAAFEKLKSAHRQQTEVIQHEVAAGSLPPSLLFNHAQDTLMV 86
Cdd:cd00215    1 LELISFQIILHAGNARSKALEALKAAKEGDFAEAEELLEEANDSLNEAHHAQTKLLQQEASGEKVEVSLLLVHAQDHLMT 80

                         90
                 ....*....|....*
gi 499508445  87 VGSELNLARSLLAIF 101
Cdd:cd00215   81 TITLKDLAKEMIELY 95
celC PRK09591
PTS cellobiose transporter subunit IIA;
3-105 2.70e-13

PTS cellobiose transporter subunit IIA;


Pssm-ID: 181975  Cd Length: 104  Bit Score: 60.58  E-value: 2.70e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499508445   3 NLEQLNLIAMRIILDAGDARDFVTKAFEAMGQRDFESADEHLRAAFEKLKSAHRQQTEVIQHEVAAGSLPPSLLFNHAQD 82
Cdd:PRK09591   2 NQEELQVAAFEIILHSGNARTEVHEAFAAMREGNFDLAEQKLNQSNEELLEAHHAQTKLLQEYASGTEIKIEIIMVHAQD 81

                         90       100
                 ....*....|....*....|...
gi 499508445  83 TLMVVGSELNLARSLLAIFINID 105
Cdd:PRK09591  82 HLMTTMTLREVAKEMLALYKKVN 104
 
Name Accession Description Interval E-value
CelC COG1447
Phosphotransferase system cellobiose-specific component IIA [Carbohydrate transport and ...
 8-107 7.04e-28

Phosphotransferase system cellobiose-specific component IIA [Carbohydrate transport and metabolism];


Pssm-ID: 441056  Cd Length: 100  Bit Score: 97.52  E-value: 7.04e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499508445   8 NLIAMRIILDAGDARDFVTKAFEAMGQRDFESADEHLRAAFEKLKSAHRQQTEVIQHEVAAGSLPPSLLFNHAQDTLMVV 87
Cdd:COG1447    1 EEIAMEIILHAGNARSLAMEALKAAKEGDFEEAEELLKEADEELLEAHKVQTELIQKEAGGEKVEVSLLLVHAQDHLMTA 80

                         90       100
                 ....*....|....*....|
gi 499508445  88 GSELNLARSLLAIFINIDRR 107
Cdd:COG1447   81 MTEKDLAKELIELYKKLEKL 100
PTS_IIA pfam02255
PTS system, Lactose/Cellobiose specific IIA subunit; The bacterial phosphoenolpyruvate: sugar ...
 9-101 1.10e-27

PTS system, Lactose/Cellobiose specific IIA subunit; The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. The lactose/cellobiose-specific family are one of four structurally and functionally distinct group IIA PTS system enzymes. This family of proteins normally function as a homotrimer, stabilized by a centrally located metal ion. Separation into subunits is thought to occur after phosphorylation.


Pssm-ID: 460510  Cd Length: 94  Bit Score: 97.12  E-value: 1.10e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499508445    9 LIAMRIILDAGDARDFVTKAFEAMGQRDFESADEHLRAAFEKLKSAHRQQTEVIQHEVAAGSLPPSLLFNHAQDTLMVVG 88
Cdd:pfam02255   1 EIAMEIILHAGNARSLAMEALKAAKEGDFEEAEELLKEADEELLEAHKAQTELIQKEAGGEKVEVSLLLVHAQDHLMTAM 80

                          90
                  ....*....|...
gi 499508445   89 SELNLARSLLAIF 101
Cdd:pfam02255  81 TEKDLAKELIELY 93
PTS_IIA_lac cd00215
PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial ...
 7-101 1.22e-20

PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four structurally and functionally distinct group IIA PTS system cytoplasmic enzymes, necessary for the uptake of carbohydrates across the cytoplasmic membrane and their phosphorylation. This family of proteins normally function as a homotrimer, stabilized by a centrally located metal ion. Separation into subunits is thought to occur after phosphorylation.


Pssm-ID: 238133  Cd Length: 97  Bit Score: 79.17  E-value: 1.22e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499508445   7 LNLIAMRIILDAGDARDFVTKAFEAMGQRDFESADEHLRAAFEKLKSAHRQQTEVIQHEVAAGSLPPSLLFNHAQDTLMV 86
Cdd:cd00215    1 LELISFQIILHAGNARSKALEALKAAKEGDFAEAEELLEEANDSLNEAHHAQTKLLQQEASGEKVEVSLLLVHAQDHLMT 80

                         90
                 ....*....|....*
gi 499508445  87 VGSELNLARSLLAIF 101
Cdd:cd00215   81 TITLKDLAKEMIELY 95
celC PRK09591
PTS cellobiose transporter subunit IIA;
3-105 2.70e-13

PTS cellobiose transporter subunit IIA;


Pssm-ID: 181975  Cd Length: 104  Bit Score: 60.58  E-value: 2.70e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499508445   3 NLEQLNLIAMRIILDAGDARDFVTKAFEAMGQRDFESADEHLRAAFEKLKSAHRQQTEVIQHEVAAGSLPPSLLFNHAQD 82
Cdd:PRK09591   2 NQEELQVAAFEIILHSGNARTEVHEAFAAMREGNFDLAEQKLNQSNEELLEAHHAQTKLLQEYASGTEIKIEIIMVHAQD 81

                         90       100
                 ....*....|....*....|...
gi 499508445  83 TLMVVGSELNLARSLLAIFINID 105
Cdd:PRK09591  82 HLMTTMTLREVAKEMLALYKKVN 104
PRK10454 PRK10454
PTS N,N'-diacetylchitobiose transporter subunit IIA;
5-108 1.54e-09

PTS N,N'-diacetylchitobiose transporter subunit IIA;


Pssm-ID: 182472  Cd Length: 115  Bit Score: 51.43  E-value: 1.54e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499508445   5 EQLNLIAMRIILDAGDARDFVTKAFEAMGQRDFESADEHLRAAFEKLKSAHRQQTEVIQHEVAAGSLPPSLLFNHAQDTL 84
Cdd:PRK10454  15 EELEEVVMGLIINSGQARSLAYAALKQAKQGDFAAAKAMMDQSRMALNEAHLVQTKLIEGDQGEGKMKVSLVLVHAQDHL 94

                         90       100
                 ....*....|....*....|....
gi 499508445  85 MVVgselNLARSLLAIFINIDRRL 108
Cdd:PRK10454  95 MTS----MLARELITELIELHEKL 114
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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