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Conserved domains on  [gi|499545258|ref|WP_011226041|]
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glycosyltransferase [Streptococcus thermophilus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5017 COG5017
UDP-N-acetylglucosamine transferase subunit ALG13 [Carbohydrate transport and metabolism];
1-158 1.82e-65

UDP-N-acetylglucosamine transferase subunit ALG13 [Carbohydrate transport and metabolism];


:

Pssm-ID: 444041 [Multi-domain]  Cd Length: 164  Bit Score: 197.07  E-value: 1.82e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499545258   1 MIFVTVGTHEQPFNRLIKEVDRLKKEGIITDEVFIQTGFSTYEPQYCDWKNIISYPEMEDYMNRADIIITHGGPATFMGA 80
Cdd:COG5017    1 MIFVTVGTHQLPFDRLVRWVDELAAEGIIDEEVFVQTGHTTYVPRNAEAVPFLPPDEFQKLIAQARLVISHAGMGSILTA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499545258  81 IAKGKKPIVVPRQEKFGEHVNDHQLDFAYQVKDRYdNIEVVEDIKTLQQFLKQ-----DLSISESTTSNNKKFNEQLRQE 155
Cdd:COG5017   81 LKLGKPFILVPRLARYGEHVDDHQLETARALEKLG-GIIVVEDPADLEAALDEalalkSPEPFSVPSPARGALVDFLRAF 159


                 ...
gi 499545258 156 VEN 158
Cdd:COG5017  160 ITE 162
 
Name Accession Description Interval E-value
COG5017 COG5017
UDP-N-acetylglucosamine transferase subunit ALG13 [Carbohydrate transport and metabolism];
1-158 1.82e-65

UDP-N-acetylglucosamine transferase subunit ALG13 [Carbohydrate transport and metabolism];


Pssm-ID: 444041 [Multi-domain]  Cd Length: 164  Bit Score: 197.07  E-value: 1.82e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499545258   1 MIFVTVGTHEQPFNRLIKEVDRLKKEGIITDEVFIQTGFSTYEPQYCDWKNIISYPEMEDYMNRADIIITHGGPATFMGA 80
Cdd:COG5017    1 MIFVTVGTHQLPFDRLVRWVDELAAEGIIDEEVFVQTGHTTYVPRNAEAVPFLPPDEFQKLIAQARLVISHAGMGSILTA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499545258  81 IAKGKKPIVVPRQEKFGEHVNDHQLDFAYQVKDRYdNIEVVEDIKTLQQFLKQ-----DLSISESTTSNNKKFNEQLRQE 155
Cdd:COG5017   81 LKLGKPFILVPRLARYGEHVDDHQLETARALEKLG-GIIVVEDPADLEAALDEalalkSPEPFSVPSPARGALVDFLRAF 159


                 ...
gi 499545258 156 VEN 158
Cdd:COG5017  160 ITE 162
PssE NF041548
PssE/Cps14G family polysaccharide biosynthesis glycosyltransferase;
2-130 3.34e-35

PssE/Cps14G family polysaccharide biosynthesis glycosyltransferase;


Pssm-ID: 469433 [Multi-domain]  Cd Length: 146  Bit Score: 119.55  E-value: 3.34e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499545258   2 IFVTVGTheQPFNRLIKEVDRLKkEGIITDEVFIQTGFSTYEPQYCDWKNIISypEMEDYMNRADIIITHGGPATFMGAI 81
Cdd:NF041548   1 IFVTVGT--TRFDSLIKAIDELI-EGLIDYEVTFQIGDGKYIPKNGEYFDFLE--EIDEYYKKADLIITHAGAGTIYSLL 75

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 499545258  82 AKGKKPIVVPRQekfgEHVNDHQLDFAYQVKDR------YDNIEVVEDIKTLQQF 130
Cdd:NF041548  76 ELGKKVIVVPNL----ERVDDHQLDLAEYVEENgyalvcYDLDELEDAIKEAENF 126
Glyco_tran_28_C pfam04101
Glycosyltransferase family 28 C-terminal domain; The glycosyltransferase family 28 includes ...
 1-151 1.07e-23

Glycosyltransferase family 28 C-terminal domain; The glycosyltransferase family 28 includes monogalactosyldiacylglycerol synthase (EC 2.4.1.46) and UDP-N-acetylglucosamine transferase (EC 2.4.1.-). Structural analysis suggests the C-terminal domain contains the UDP-GlcNAc binding site.


Pssm-ID: 427711 [Multi-domain]  Cd Length: 166  Bit Score: 90.85  E-value: 1.07e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499545258    1 MIFVTVGTHE-QPFNRLIKEVDRLKKEGIITdEVFIQTGFSTYEPQYCDWKN------IISY-PEMEDYMNRADIIITHG 72
Cdd:pfam04101   1 TILVTGGSQGaRALNELVLSVLPLLELKGEL-QVLHQTGKGDLEEVKIDYAElginyeVFPFiDNMAEYIKAADLVISRA 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 499545258   73 GPATFMGAIAKGKKPIVVPRQEKFGEHVNDHQLDFAYQVKDRYdNIEVVEDIKTLQQFLKQDLSISESTTSNNKKFNEQ 151
Cdd:pfam04101  80 GAGTIAELLALGKPAILVPNPSAARGHQDNNAKELVKAGAALV-ILQKELTPEKLIEALLKLLLNPLRLAEMAKASKAS 157
GT28_MurG cd03785
undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; MurG (EC 2.4. ...
 11-104 1.20e-04

undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; MurG (EC 2.4.1.227) is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide (NAM). The resulting disaccharide is then transported across the cell membrane, where it is polymerized into NAG-NAM cell-wall repeat structure. MurG belongs to the GT-B structural superfamily of glycoslytransferases, which have characteristic N- and C-terminal domains, each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340818 [Multi-domain]  Cd Length: 350  Bit Score: 41.05  E-value: 1.20e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499545258  11 QPFNRLIKEV-DRLKKEGIitdEVFIQTGFSTYEP---QYCD-WKNIISYP---EMEDYMNRADIIITHGGPATFMGAIA 82
Cdd:cd03785  194 RAINRAVPKAlPKLLERGI---QVIHQTGKGDYDEvkkLYEDlGINVKVFPfidDMAAAYAAADLVISRAGASTIAELTA 270

                         90       100
                 ....*....|....*....|..
gi 499545258  83 KGKKPIVVPrqekFGEHVNDHQ 104
Cdd:cd03785  271 AGKPAILIP----YPYAADDHQ 288
PLN02605 PLN02605
monogalactosyldiacylglycerol synthase
 58-95 7.86e-03

monogalactosyldiacylglycerol synthase


Pssm-ID: 215325 [Multi-domain]  Cd Length: 382  Bit Score: 35.71  E-value: 7.86e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 499545258  58 MEDYMNRADIIITHGGPATFMGAIAKGkKPIV----VPRQEK 95
Cdd:PLN02605 276 MEEWMGACDCIITKAGPGTIAEALIRG-LPIIlngyIPGQEE 316
 
Name Accession Description Interval E-value
COG5017 COG5017
UDP-N-acetylglucosamine transferase subunit ALG13 [Carbohydrate transport and metabolism];
1-158 1.82e-65

UDP-N-acetylglucosamine transferase subunit ALG13 [Carbohydrate transport and metabolism];


Pssm-ID: 444041 [Multi-domain]  Cd Length: 164  Bit Score: 197.07  E-value: 1.82e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499545258   1 MIFVTVGTHEQPFNRLIKEVDRLKKEGIITDEVFIQTGFSTYEPQYCDWKNIISYPEMEDYMNRADIIITHGGPATFMGA 80
Cdd:COG5017    1 MIFVTVGTHQLPFDRLVRWVDELAAEGIIDEEVFVQTGHTTYVPRNAEAVPFLPPDEFQKLIAQARLVISHAGMGSILTA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499545258  81 IAKGKKPIVVPRQEKFGEHVNDHQLDFAYQVKDRYdNIEVVEDIKTLQQFLKQ-----DLSISESTTSNNKKFNEQLRQE 155
Cdd:COG5017   81 LKLGKPFILVPRLARYGEHVDDHQLETARALEKLG-GIIVVEDPADLEAALDEalalkSPEPFSVPSPARGALVDFLRAF 159


                 ...
gi 499545258 156 VEN 158
Cdd:COG5017  160 ITE 162
PssE NF041548
PssE/Cps14G family polysaccharide biosynthesis glycosyltransferase;
2-130 3.34e-35

PssE/Cps14G family polysaccharide biosynthesis glycosyltransferase;


Pssm-ID: 469433 [Multi-domain]  Cd Length: 146  Bit Score: 119.55  E-value: 3.34e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499545258   2 IFVTVGTheQPFNRLIKEVDRLKkEGIITDEVFIQTGFSTYEPQYCDWKNIISypEMEDYMNRADIIITHGGPATFMGAI 81
Cdd:NF041548   1 IFVTVGT--TRFDSLIKAIDELI-EGLIDYEVTFQIGDGKYIPKNGEYFDFLE--EIDEYYKKADLIITHAGAGTIYSLL 75

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 499545258  82 AKGKKPIVVPRQekfgEHVNDHQLDFAYQVKDR------YDNIEVVEDIKTLQQF 130
Cdd:NF041548  76 ELGKKVIVVPNL----ERVDDHQLDLAEYVEENgyalvcYDLDELEDAIKEAENF 126
Glyco_tran_28_C pfam04101
Glycosyltransferase family 28 C-terminal domain; The glycosyltransferase family 28 includes ...
 1-151 1.07e-23

Glycosyltransferase family 28 C-terminal domain; The glycosyltransferase family 28 includes monogalactosyldiacylglycerol synthase (EC 2.4.1.46) and UDP-N-acetylglucosamine transferase (EC 2.4.1.-). Structural analysis suggests the C-terminal domain contains the UDP-GlcNAc binding site.


Pssm-ID: 427711 [Multi-domain]  Cd Length: 166  Bit Score: 90.85  E-value: 1.07e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499545258    1 MIFVTVGTHE-QPFNRLIKEVDRLKKEGIITdEVFIQTGFSTYEPQYCDWKN------IISY-PEMEDYMNRADIIITHG 72
Cdd:pfam04101   1 TILVTGGSQGaRALNELVLSVLPLLELKGEL-QVLHQTGKGDLEEVKIDYAElginyeVFPFiDNMAEYIKAADLVISRA 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 499545258   73 GPATFMGAIAKGKKPIVVPRQEKFGEHVNDHQLDFAYQVKDRYdNIEVVEDIKTLQQFLKQDLSISESTTSNNKKFNEQ 151
Cdd:pfam04101  80 GAGTIAELLALGKPAILVPNPSAARGHQDNNAKELVKAGAALV-ILQKELTPEKLIEALLKLLLNPLRLAEMAKASKAS 157
YjiC COG1819
UDP:flavonoid glycosyltransferase YjiC, YdhE family [Carbohydrate transport and metabolism];
2-111 6.42e-06

UDP:flavonoid glycosyltransferase YjiC, YdhE family [Carbohydrate transport and metabolism];


Pssm-ID: 441424 [Multi-domain]  Cd Length: 268  Bit Score: 44.46  E-value: 6.42e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499545258   2 IFVTVGTHEQPFNRLIKEV-DRLKKEGIitdEVFIQTGFSTYEPQYCDWKN--IISYPEMEDYMNRADIIITHGGPATFM 78
Cdd:COG1819  123 VYVTLGTSANDRADLLRAVlEALADLGV---RVVVTTGGLDPAELGPLPDNvrVVDYVPQDALLPRADAVVHHGGAGTTA 199

                         90       100       110
                 ....*....|....*....|....*....|...
gi 499545258  79 GAIAKGKKPIVVPrqekfgeHVNDhQLDFAYQV 111
Cdd:COG1819  200 EALRAGVPQVVVP-------FGGD-QPLNAARV 224
GT28_MurG cd03785
undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; MurG (EC 2.4. ...
 11-104 1.20e-04

undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; MurG (EC 2.4.1.227) is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide (NAM). The resulting disaccharide is then transported across the cell membrane, where it is polymerized into NAG-NAM cell-wall repeat structure. MurG belongs to the GT-B structural superfamily of glycoslytransferases, which have characteristic N- and C-terminal domains, each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340818 [Multi-domain]  Cd Length: 350  Bit Score: 41.05  E-value: 1.20e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499545258  11 QPFNRLIKEV-DRLKKEGIitdEVFIQTGFSTYEP---QYCD-WKNIISYP---EMEDYMNRADIIITHGGPATFMGAIA 82
Cdd:cd03785  194 RAINRAVPKAlPKLLERGI---QVIHQTGKGDYDEvkkLYEDlGINVKVFPfidDMAAAYAAADLVISRAGASTIAELTA 270

                         90       100
                 ....*....|....*....|..
gi 499545258  83 KGKKPIVVPrqekFGEHVNDHQ 104
Cdd:cd03785  271 AGKPAILIP----YPYAADDHQ 288
COG4671 COG4671
Predicted glycosyl transferase [General function prediction only];
56-93 2.76e-04

Predicted glycosyl transferase [General function prediction only];


Pssm-ID: 443708 [Multi-domain]  Cd Length: 391  Bit Score: 39.84  E-value: 2.76e-04
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 499545258  56 PEMEDYMNRADIIITHGGPATFMGAIAKGKKPIVVPRQ 93
Cdd:COG4671  283 PDFEALLAAADLSVSMGGYNTVCEILSTGKPALIVPRT 320
MurG COG0707
UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell wall/membrane/envelope ...
 11-104 5.91e-04

UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440471 [Multi-domain]  Cd Length: 363  Bit Score: 38.96  E-value: 5.91e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499545258  11 QPFNRLIKEV-DRLKKEGIitdEVFIQTG---FSTYEPQYCD--WKNIISYP---EMEDYMNRADIIITHGGpATFMGAI 81
Cdd:COG0707  199 RALNEAVPAAlAALLEARL---QVVHQTGkgdYEEVRAAYAAaiRPNAEVFPfidDMADAYAAADLVISRAG-ASTVAEL 274

                         90       100
                 ....*....|....*....|....
gi 499545258  82 AKGKKP-IVVPrqekFGEHVNDHQ 104
Cdd:COG0707  275 AALGKPaILVP----LPHAADDHQ 294
GT28_Beta-DGS-like cd17507
beta-diglucosyldiacylglycerol synthase and similar proteins; beta-diglucosyldiacylglycerol ...
 57-124 1.44e-03

beta-diglucosyldiacylglycerol synthase and similar proteins; beta-diglucosyldiacylglycerol synthase (processive diacylglycerol beta-glucosyltransferase EC 2.4.1.315) is involved in the biosynthesis of both the bilayer- and non-bilayer-forming membrane glucolipids. This family of glycosyltransferases also contains plant major galactolipid synthase (chloroplastic monogalactosyldiacylglycerol synthase 1 EC 2.4.1.46). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. The structures of the formed glycoconjugates are extremely diverse, reflecting a wide range of biological functions. The members of this family share a common GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340861 [Multi-domain]  Cd Length: 364  Bit Score: 37.68  E-value: 1.44e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 499545258  57 EMEDYMNRADIIITHGGPATFMGAIAKGkKPIVV----PRQEKfgehvndHQLDF------AYQVKDRYDNIEVVEDI 124
Cdd:cd17507  260 DMNELMAASDLVITKPGGLTISEALARG-LPVIIydpiPGQEE-------ENADFlenngaGIIARDPEELLEIVARL 329
PLN02605 PLN02605
monogalactosyldiacylglycerol synthase
 58-95 7.86e-03

monogalactosyldiacylglycerol synthase


Pssm-ID: 215325 [Multi-domain]  Cd Length: 382  Bit Score: 35.71  E-value: 7.86e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 499545258  58 MEDYMNRADIIITHGGPATFMGAIAKGkKPIV----VPRQEK 95
Cdd:PLN02605 276 MEEWMGACDCIITKAGPGTIAEALIRG-LPIIlngyIPGQEE 316
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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