|
Name |
Accession |
Description |
Interval |
E-value |
| pgi |
PRK14097 |
glucose-6-phosphate isomerase; Provisional |
1-448 |
0e+00 |
|
glucose-6-phosphate isomerase; Provisional
Pssm-ID: 184504 Cd Length: 448 Bit Score: 915.38 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499566965 1 MAHIQFDYSKALSFFGEHEVAYMREAVRAAHKALHEKTGQGNDFLGWIDLPVDYDKEEFARIQKAAEKIRHDSDVLLVVG 80
Cdd:PRK14097 1 MTHIKFDYSKALSFVGEHELEYLQPQVKAAHQTLHNGTGAGNDFLGWLDLPENYDKEEFARIKKAAEKIKSDSDVLVVIG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499566965 81 IGGSYLGARAAIEALNHSFFNQLPKEKRNAPQVIFVGQNISSTYLSDVLDLLDGKDVSVNVISKSGTTTEPAIAFRVFRD 160
Cdd:PRK14097 81 IGGSYLGARAAIEFLNHSFYNLLPKEQRKAPQIIFAGNSISSTYLADLLEYLKDKDFSINVISKSGTTTEPAIAFRIFKE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499566965 161 YLEKKYGKEEARKRIYATTDKERGALKTLANEEGYESFVIPDDVGGRFSVLTAVGLLPIAVSGLAIEDMMKGAADAREAF 240
Cdd:PRK14097 161 LLEKKYGKEEAKKRIYATTDKAKGALKTLADAEGYETFVIPDDVGGRFSVLTAVGLLPIAVAGIDIDALMKGAADARKDY 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499566965 241 STGELSENAAYQYAAIRNILYNKGKTIELLVNYEPHLHYVSEWWKQLFGESEGKDQKGIYPASVDFSTDLHSMGQYVQDG 320
Cdd:PRK14097 241 SSSDLSENPAYQYAAVRNILYRKGYTTEILVNYEPSLQYFSEWWKQLFGESEGKDQKGIFPASANFSTDLHSLGQYIQEG 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499566965 321 RRNLFETVLHVEAVDKHITIEEAESDLDGLNYLAGKTMDFVNKQAFKGTMLAHTDGNVPNLVVSIPKLDEYSFGYLVYFF 400
Cdd:PRK14097 321 RRNLFETVIKVEKPRKDLTIPEDEEDLDGLNYLAGKTVDFVNKKAFEGTLLAHTDGGVPNIVVNIPELDEYTFGYLVYFF 400
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 499566965 401 EKAVAMSGYLLGVNPFDQPGVEAYKKNMFALLGKPGFEEEKNKLESRL 448
Cdd:PRK14097 401 EKACAISGYLLGVNPFDQPGVEAYKKNMFALLGKPGFEELKAELEARL 448
|
|
| Pgi |
COG0166 |
Glucose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Glucose-6-phosphate ... |
2-441 |
0e+00 |
|
Glucose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Glucose-6-phosphate isomerase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 439936 Cd Length: 484 Bit Score: 575.55 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499566965 2 AHIQFDYSKAlsFFGEHEVAYMREAVRA--AHKALH--------EKTGQGndfLGWIDLP------VDYDKEEFARIQKA 65
Cdd:COG0166 21 AGLLLDYSKN--RITDETLELLLELAEEeeAREALFagekinptEGRAVL---HGALRLPeagedvMPEVREELARIKAF 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499566965 66 AEKIRH--DSDVLLVVGIGGSYLGARAAIEALNHSFfnqlpkekRNAPqVIFVGQNISSTYLSDVLDLLDGKDVSVNVIS 143
Cdd:COG0166 96 AEKVRTgkRITDVVNIGIGGSDLGPRAVIEALKPYF--------RDGP-RVHFVSNVDPDYLAELLAGLDPETTLFIVIS 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499566965 144 KSGTTTEPAIAFRVFRDYLEKKyGKEEARKRIYATTDKErGALKTLANEEGYESFVIPDDVGGRFSVLTAVGLLPIAVSG 223
Cdd:COG0166 167 KSGTTQETLTNARVAREWLEKA-GGEDAAKHFVAVTDNA-GALRAFGIDEGYNTFPFPDWVGGRYSVLSAVGLLPAAAIG 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499566965 224 LAIEDMMKGAADAREAFSTGELSENAAYQYAAIRNILYN-KGKTIELLVNYEPHLHYVSEWWKQLFGESEGKD------- 295
Cdd:COG0166 245 IDFEELLAGAHAMDEHFRTAPLEENPPVLLALLGIWYRNfKGAETEAVLPYDQRLERFPAWLQQLWMESNGKSvdrdgnp 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499566965 296 -QKGIYPASVDFSTDLHSMGQYVQDGRRNLFETVLHVEAVDKHITiEEAESDLDGLNYLAGKTMDFVNKQAFKGTMLAHT 374
Cdd:COG0166 325 vGYGTGPVGEPGTTDQHSFGQLLHQGTRDIPVTFIAVAEPHHDIP-DLLLANLQGLALLAGKTLDEVLALAAEATPHALF 403
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 499566965 375 DGNVPNLVVSIPKLDEYSFGYLVYFFEKAVAMSGYLLGVNPFDQPGVEAYKKNMFALLGKPGFEEEK 441
Cdd:COG0166 404 PGNRPSNTILLPKLTPYTLGALIALYEHAVFVQGVLWGINPFDQPGVELGKKLAFALLGKLGGEEAA 470
|
|
| SIS_PGI_2 |
cd05016 |
Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification ... |
267-431 |
1.51e-58 |
|
Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of glucose 6-phosphate to fructose 6-phosphate. As an extracellular protein, PGI also has functions equivalent to neuroleukin (NLK), autocrine motility factor (AMF), and maturation factor (MF). Evidence suggests that PGI, NLK, AMF, and MF are closely related or identical. NLK is a neurotrophic growth factor that promotes regeneration and survival of neurons. The dimeric form of NLK has isomerase function, whereas its monomeric form carries out neurotrophic activity. AMF is a cytokine that stimulates cell migration and metastasis. MF mediates the differentiation of human myeloid leukemic HL-60 cells to terminal monocytic cells.
Pssm-ID: 240147 Cd Length: 164 Bit Score: 189.73 E-value: 1.51e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499566965 267 IELLVNYEPHLHYVSEWWKQLFGESEGKDQK--------GIYPASVDFSTDLHSMGQYVQDGRRNLFETVLHVEavdkhi 338
Cdd:cd05016 2 THALLPYSQRLERFPAWLQQLDMESNGKSVTrdgedyptGPIPWGAPGTNDQHSFFQLIHQGTKDKPVDFIAVK------ 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499566965 339 tieeaESDLDGLNYLAGKTMDFVNKQAFKGTMLAH-TDGNVPNLVVSIPKLDEYSFGYLVYFFEKAVAMSGYLLGVNPFD 417
Cdd:cd05016 76 -----KPQNDVLDYLAGKTLHDLLLANCLATREALmFPGGRPSNTIVLPELTPYTLGALLALYEHKTAVQGALLGINPFD 150
|
170
....*....|....
gi 499566965 418 QPGVEAYKKNMFAL 431
Cdd:cd05016 151 QPGVELGKKLAKKI 164
|
|
| PGI |
pfam00342 |
Phosphoglucose isomerase; Phosphoglucose isomerase catalyzes the interconversion of ... |
76-422 |
9.72e-25 |
|
Phosphoglucose isomerase; Phosphoglucose isomerase catalyzes the interconversion of glucose-6-phosphate and fructose-6-phosphate.
Pssm-ID: 395271 Cd Length: 487 Bit Score: 106.41 E-value: 9.72e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499566965 76 LLVVGIGGSYLGARAAIEALNHsffnqlpkEKRNAPQVIFVGqNISSTYLSDVLDLLDGKDVSVNVISKSGTTTEPAIAF 155
Cdd:pfam00342 99 VVNIGIGGSDLGPVMVTEALKP--------YSGRDLDVHFVS-NVDGTHIAEVLKKLNPETTLFIVASKTFTTAETMTNA 169
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499566965 156 RVFRDYLeKKYGKEE---ARKRIYATTDKErgalktLANEEGYES---FVIPDDVGGRFSVLTAVGLlPIAVS-GLAI-E 227
Cdd:pfam00342 170 ESAKEWL-LKALKDDsavAKHFIALSTNAE------KVEEFGIDTknmFEFWDWVGGRYSLWSAIGL-PIALSiGFENfQ 241
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499566965 228 DMMKGAADAREAFSTGELSENAAYqYAAIRNILYNK--GKTIELLVNYEPHLHYVSEWWKQLFGESEGK--DQKGIYpas 303
Cdd:pfam00342 242 QLLEGAHAMDKHFLSAPPEKNIPV-LLALLGVWYNNffGAQTHAILPYDQYLHRFPAYLQQLDMESNGKyvTRDGVL--- 317
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499566965 304 VDFSTDLHSMGQYVQDGRRNLFEtVLH----------VEAVDKHITIEEAESDLDGLNYLA-------GKTMDFVNKQAF 366
Cdd:pfam00342 318 VDHQTGPIIFGEPGTNGQHAFYQ-LIHqgtrlipcdfIGAVQSQNPENGDHHKILLSNFFAqtealmvGKSPEEVRKELA 396
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 499566965 367 KGT---MLAHT--DGNVPNLVVSIPKLDEYSFGYLVYFFEKAVAMSGYLLGVNPFDQPGVE 422
Cdd:pfam00342 397 AADvehLIPHKtfTGNRPSNSILVQKLTPATLGALIAMYEHKIFVQGAIWGINSFDQWGVE 457
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| pgi |
PRK14097 |
glucose-6-phosphate isomerase; Provisional |
1-448 |
0e+00 |
|
glucose-6-phosphate isomerase; Provisional
Pssm-ID: 184504 Cd Length: 448 Bit Score: 915.38 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499566965 1 MAHIQFDYSKALSFFGEHEVAYMREAVRAAHKALHEKTGQGNDFLGWIDLPVDYDKEEFARIQKAAEKIRHDSDVLLVVG 80
Cdd:PRK14097 1 MTHIKFDYSKALSFVGEHELEYLQPQVKAAHQTLHNGTGAGNDFLGWLDLPENYDKEEFARIKKAAEKIKSDSDVLVVIG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499566965 81 IGGSYLGARAAIEALNHSFFNQLPKEKRNAPQVIFVGQNISSTYLSDVLDLLDGKDVSVNVISKSGTTTEPAIAFRVFRD 160
Cdd:PRK14097 81 IGGSYLGARAAIEFLNHSFYNLLPKEQRKAPQIIFAGNSISSTYLADLLEYLKDKDFSINVISKSGTTTEPAIAFRIFKE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499566965 161 YLEKKYGKEEARKRIYATTDKERGALKTLANEEGYESFVIPDDVGGRFSVLTAVGLLPIAVSGLAIEDMMKGAADAREAF 240
Cdd:PRK14097 161 LLEKKYGKEEAKKRIYATTDKAKGALKTLADAEGYETFVIPDDVGGRFSVLTAVGLLPIAVAGIDIDALMKGAADARKDY 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499566965 241 STGELSENAAYQYAAIRNILYNKGKTIELLVNYEPHLHYVSEWWKQLFGESEGKDQKGIYPASVDFSTDLHSMGQYVQDG 320
Cdd:PRK14097 241 SSSDLSENPAYQYAAVRNILYRKGYTTEILVNYEPSLQYFSEWWKQLFGESEGKDQKGIFPASANFSTDLHSLGQYIQEG 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499566965 321 RRNLFETVLHVEAVDKHITIEEAESDLDGLNYLAGKTMDFVNKQAFKGTMLAHTDGNVPNLVVSIPKLDEYSFGYLVYFF 400
Cdd:PRK14097 321 RRNLFETVIKVEKPRKDLTIPEDEEDLDGLNYLAGKTVDFVNKKAFEGTLLAHTDGGVPNIVVNIPELDEYTFGYLVYFF 400
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 499566965 401 EKAVAMSGYLLGVNPFDQPGVEAYKKNMFALLGKPGFEEEKNKLESRL 448
Cdd:PRK14097 401 EKACAISGYLLGVNPFDQPGVEAYKKNMFALLGKPGFEELKAELEARL 448
|
|
| Pgi |
COG0166 |
Glucose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Glucose-6-phosphate ... |
2-441 |
0e+00 |
|
Glucose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Glucose-6-phosphate isomerase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 439936 Cd Length: 484 Bit Score: 575.55 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499566965 2 AHIQFDYSKAlsFFGEHEVAYMREAVRA--AHKALH--------EKTGQGndfLGWIDLP------VDYDKEEFARIQKA 65
Cdd:COG0166 21 AGLLLDYSKN--RITDETLELLLELAEEeeAREALFagekinptEGRAVL---HGALRLPeagedvMPEVREELARIKAF 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499566965 66 AEKIRH--DSDVLLVVGIGGSYLGARAAIEALNHSFfnqlpkekRNAPqVIFVGQNISSTYLSDVLDLLDGKDVSVNVIS 143
Cdd:COG0166 96 AEKVRTgkRITDVVNIGIGGSDLGPRAVIEALKPYF--------RDGP-RVHFVSNVDPDYLAELLAGLDPETTLFIVIS 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499566965 144 KSGTTTEPAIAFRVFRDYLEKKyGKEEARKRIYATTDKErGALKTLANEEGYESFVIPDDVGGRFSVLTAVGLLPIAVSG 223
Cdd:COG0166 167 KSGTTQETLTNARVAREWLEKA-GGEDAAKHFVAVTDNA-GALRAFGIDEGYNTFPFPDWVGGRYSVLSAVGLLPAAAIG 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499566965 224 LAIEDMMKGAADAREAFSTGELSENAAYQYAAIRNILYN-KGKTIELLVNYEPHLHYVSEWWKQLFGESEGKD------- 295
Cdd:COG0166 245 IDFEELLAGAHAMDEHFRTAPLEENPPVLLALLGIWYRNfKGAETEAVLPYDQRLERFPAWLQQLWMESNGKSvdrdgnp 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499566965 296 -QKGIYPASVDFSTDLHSMGQYVQDGRRNLFETVLHVEAVDKHITiEEAESDLDGLNYLAGKTMDFVNKQAFKGTMLAHT 374
Cdd:COG0166 325 vGYGTGPVGEPGTTDQHSFGQLLHQGTRDIPVTFIAVAEPHHDIP-DLLLANLQGLALLAGKTLDEVLALAAEATPHALF 403
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 499566965 375 DGNVPNLVVSIPKLDEYSFGYLVYFFEKAVAMSGYLLGVNPFDQPGVEAYKKNMFALLGKPGFEEEK 441
Cdd:COG0166 404 PGNRPSNTILLPKLTPYTLGALIALYEHAVFVQGVLWGINPFDQPGVELGKKLAFALLGKLGGEEAA 470
|
|
| PRK00973 |
PRK00973 |
glucose-6-phosphate isomerase; Provisional |
4-449 |
7.71e-118 |
|
glucose-6-phosphate isomerase; Provisional
Pssm-ID: 179193 [Multi-domain] Cd Length: 446 Bit Score: 351.99 E-value: 7.71e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499566965 4 IQFDYSKALSF-----FGEHEVAYMREAVRAAHKALHEKTGQGNdfLGWIDLPVDYDKEEFARIQKAAEkirhDSDVLLV 78
Cdd:PRK00973 3 LKFDFSNVFEPnigggISIEDIESVKEKITSAVENLMEKEPNGE--LGFLELPYDRSLDSYEELKEWSK----NFDNVVV 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499566965 79 VGIGGSYLGARAAIEALNHSFFNQLPKEKRNAPQVIFVgQNISSTYLSDVLDLLDGKDVSVNVISKSGTTTEPAIAFRVF 158
Cdd:PRK00973 77 LGIGGSALGNLALHYALNPLNWNELSKEERNGPRVFVL-DNVDPEKTASILDVIDLEKTLFNVISKSGNTAETLANYLII 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499566965 159 RDYLEKKygKEEARKRIYATTDKERGALKTLANEEGYESFVIPDDVGGRFSVLTAVGLLPIAVSGLAIEDMMKGAADARE 238
Cdd:PRK00973 156 RGILEKL--GLDPKKHLVFTTDPEKGKLKKIAEKEGYRTLEIPENVGGRFSVLTPVGLAPAAALGIDIEELLEGAKEMDK 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499566965 239 AFSTGELSENAAYQYAAIRNILYNKGKTIELLVNYEPHLHYVSEWWKQLFGESEGKDQKGIYPASVDFSTDLHSMGQYVQ 318
Cdd:PRK00973 234 ICEKEDIFKNPALLNALIHYLYYNRGKNISVMMPYSERLKYFGDWYRQLWAESLGKKGVGQTPVKALGATDQHSQLQLYM 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499566965 319 DGRRNLFETVLHVEAVDKHITIEEAESDLDGLNYLAGKTMDFVNKQAFKGTMLAHTDGNVPNLVVSIPKLDEYSFGYLVY 398
Cdd:PRK00973 314 EGPKDKIITFLKVEKYRRDVEIPYEYEDIEELSYLGGHKLSELINSEQKGTEIALTENGRPNVKITLDELNEYTVGQLFY 393
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|.
gi 499566965 399 FFEKAVAMSGYLLGVNPFDQPGVEAYKKNMFALLGKPGFEEEKNKLESRLT 449
Cdd:PRK00973 394 MYEMQTAFMGELLNINAFDQPGVELGKKITYALLGRSGYEEEKKEIEKKVI 444
|
|
| SIS_PGI_2 |
cd05016 |
Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification ... |
267-431 |
1.51e-58 |
|
Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of glucose 6-phosphate to fructose 6-phosphate. As an extracellular protein, PGI also has functions equivalent to neuroleukin (NLK), autocrine motility factor (AMF), and maturation factor (MF). Evidence suggests that PGI, NLK, AMF, and MF are closely related or identical. NLK is a neurotrophic growth factor that promotes regeneration and survival of neurons. The dimeric form of NLK has isomerase function, whereas its monomeric form carries out neurotrophic activity. AMF is a cytokine that stimulates cell migration and metastasis. MF mediates the differentiation of human myeloid leukemic HL-60 cells to terminal monocytic cells.
Pssm-ID: 240147 Cd Length: 164 Bit Score: 189.73 E-value: 1.51e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499566965 267 IELLVNYEPHLHYVSEWWKQLFGESEGKDQK--------GIYPASVDFSTDLHSMGQYVQDGRRNLFETVLHVEavdkhi 338
Cdd:cd05016 2 THALLPYSQRLERFPAWLQQLDMESNGKSVTrdgedyptGPIPWGAPGTNDQHSFFQLIHQGTKDKPVDFIAVK------ 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499566965 339 tieeaESDLDGLNYLAGKTMDFVNKQAFKGTMLAH-TDGNVPNLVVSIPKLDEYSFGYLVYFFEKAVAMSGYLLGVNPFD 417
Cdd:cd05016 76 -----KPQNDVLDYLAGKTLHDLLLANCLATREALmFPGGRPSNTIVLPELTPYTLGALLALYEHKTAVQGALLGINPFD 150
|
170
....*....|....
gi 499566965 418 QPGVEAYKKNMFAL 431
Cdd:cd05016 151 QPGVELGKKLAKKI 164
|
|
| SIS_PGI_1 |
cd05015 |
Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification ... |
56-221 |
1.16e-57 |
|
Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of glucose 6-phosphate to fructose 6-phosphate. As an extracellular protein, PGI also has functions equivalent to neuroleukin (NLK), autocrine motility factor (AMF), and maturation factor (MF). Evidence suggests that PGI, NLK, AMF, and MF are closely related or identical. NLK is a neurotrophic growth factor that promotes regeneration and survival of neurons. The dimeric form of NLK has isomerase function, whereas its monomeric form carries out neurotrophic activity. AMF is a cytokine that stimulates cell migration and metastasis. MF mediates the differentiation of human myeloid leukemic HL-60 cells to terminal monocytic cells.
Pssm-ID: 240146 Cd Length: 158 Bit Score: 186.96 E-value: 1.16e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499566965 56 KEEFARIQKAAEKIR--HDSDVLLVVGIGGSYLGARAAIEALNHSFFNqlpkekrnAPQVIFVGqNISSTYLSDVLDLLD 133
Cdd:cd05015 1 RAELERIKEFAEKVRsgKKITDVVVIGIGGSDLGPRAVYEALKPYFKG--------GLRLHFVS-NVDPDDLAELLKKLD 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499566965 134 GKDVSVNVISKSGTTTEPAIAFRVFRDYLEKKYGkEEARKRIYATTDKERGALKTlANEEGYESFVIPDDVGGRFSVLTA 213
Cdd:cd05015 72 PETTLFIVISKSGTTLETLANARLAREWLEEAGG-DDLAKHFVAITDNGSGLLKK-AGIEGLNTFEIPDWVGGRFSVLSS 149
|
....*...
gi 499566965 214 VGLLPIAV 221
Cdd:cd05015 150 VGGLPLAL 157
|
|
| PRK03868 |
PRK03868 |
glucose-6-phosphate isomerase; Provisional |
29-429 |
2.25e-55 |
|
glucose-6-phosphate isomerase; Provisional
Pssm-ID: 235168 Cd Length: 410 Bit Score: 189.37 E-value: 2.25e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499566965 29 AAHKALHEKTgqgNDFLGWIDLPvDYDK---EEFARIQKAAEKIRHdsdvLLVVGIGGSYLGARAAiealnHSFFNQLPK 105
Cdd:PRK03868 19 YFERINKEKE---SGEIGYYHLP-DQSTsliEESLKFVKDKESIKN----IVVIGIGGSSLGVKAI-----YSFLKNEKN 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499566965 106 EKRNapqvIFVGQNISSTYLSDVLDLLDGKDVSVNVISKSGTTTEPAIAFRvfrdYLEKKYG-KEEARKRIYATTDKErG 184
Cdd:PRK03868 86 NKKE----LHFLENTDPISINKTLSKINLENTLFIVISKSGTTIETISIFK----YLLSHFKlDQELKKNFLFITDPD-S 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499566965 185 ALKTLANEEGYESFVIPDDVGGRFSVLTAVGLLPIAVSGLAIEDMMKGAADAREAFSTGELSE--NAAYQYAAIRNIlYN 262
Cdd:PRK03868 157 KLEQFAKENNIKCFNIPKNVGGRFSVLSAVGIVPLALCGYDIKALLEGAKACKDSFFEQKEDHilKKAYFYATHKNA-YN 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499566965 263 kgktIELLVNYEPHLHYVSEWWKQLFGESEGKDQK-----GIYPASVDFSTDLHSMGQYVQDGRRNLFETVLHVEAVDKH 337
Cdd:PRK03868 236 ----INVLFSYSDALKGFNDWYVQLWGESLGKKQGyktrvGLTPIGLIGSRDQHSFLQLIMEGPRDKTVTFIKIKDFQNA 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499566965 338 ITIEEAE-SDLDGLNYLAGKTM-DFVNKQAfKGTMLAHTDGNVPNLVVSIPKLDEYSFGYLVYFFEKAVAMSGYLLGVNP 415
Cdd:PRK03868 312 PKIPNISlKGLESLDFVNGVSFnELINAQC-DATMEALIAEDIPVDVITLEKLDEFSIGYLIYYYELLTSAVGKMLGINT 390
|
410
....*....|....*..
gi 499566965 416 FDQPGVEAYK---KNMF 429
Cdd:PRK03868 391 YDQPGVEVGKrilKEKL 407
|
|
| pgi |
PRK14096 |
glucose-6-phosphate isomerase; Provisional |
57-426 |
6.95e-34 |
|
glucose-6-phosphate isomerase; Provisional
Pssm-ID: 237609 [Multi-domain] Cd Length: 528 Bit Score: 133.09 E-value: 6.95e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499566965 57 EEFARIQKAAEKIrHDSDV----------LLVVGIGGSYLGARAAIEALnhsffnqlpkEKRNAPQVIFVGQNISSTYLS 126
Cdd:PRK14096 89 ETLAQIEAFAAKV-HSGTIkppngekftdVLWIGIGGSALGPQFVAEAL----------QPNSDGLNIHFIDNTDPDGID 157
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499566965 127 DVLDLLDGKDVS--VNVISKSGTTTEPAIAFRVFRDYLEKKyGKEEARKRIYATTDKERgaLKTLANEEGY-ESFVIPDD 203
Cdd:PRK14096 158 RVLAELGDRLATtlVVVISKSGGTPETRNGMLEAKAAYEAA-GLDFASHAVAITMKGSK--LDQLAQSEGWlARFPMWDW 234
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499566965 204 VGGRFSVLTAVGLLPIAVSGLAIEDMMKGAADAREAFSTGELSEN-----AAYQYAAIRNilynKGKTIELLVNYEPHLH 278
Cdd:PRK14096 235 VGGRTSETSAVGLLPAALQGIDIRAFLAGAKQMDEATRVPDLKNNpaallALAWYYAGDG----KGKKDMVVLPYKDRLL 310
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499566965 279 YVSEWWKQLFGESEGKDQ----------------KGiypasvdfSTDLHSmgqYVQ---DGRRNLFET---VLHVEAVDk 336
Cdd:PRK14096 311 LFSRYLQQLVMESLGKELdldgnvvhqgiavygnKG--------STDQHA---YVQqlrDGVDNFFVTfieVLEDRQGS- 378
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499566965 337 HITIEEAESDLDglnYLAGktmdFvnkqaFKGTMLAHTDGNVPNLVVSIPKLDEYSFGYLVYFFEKAVAMSGYLLGVNPF 416
Cdd:PRK14096 379 SIEVEPGVTSGD---YLSG----F-----LQGTRQALYENGRQSITITIPEVNPRTLGALIALFERAVGLYASLVNINAY 446
|
410
....*....|
gi 499566965 417 DQPGVEAYKK 426
Cdd:PRK14096 447 HQPGVEAGKK 456
|
|
| PLN02649 |
PLN02649 |
glucose-6-phosphate isomerase |
61-426 |
2.53e-32 |
|
glucose-6-phosphate isomerase
Pssm-ID: 215351 [Multi-domain] Cd Length: 560 Bit Score: 129.00 E-value: 2.53e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499566965 61 RIQKAAEKIRHDSDV---------LLVVGIGGSYLGARAAIEALNHsffNQLPKEKRNAPQVIFVGqNISSTYLSDVLDL 131
Cdd:PLN02649 126 KIKAFSEDVRSGKWKgatgkrftnVVSIGIGGSFLGPLFVHEALAT---DPEALKSAKGRKLRFLA-NVDPVDIARQIAQ 201
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499566965 132 LDGKDVSVNVISKSGTTTEPAIAFRVFRDYLEKKYGKEEARKRIYATTdkERGALKTLANEEGYESFVIPDDVGGRFSVL 211
Cdd:PLN02649 202 LDPETTLVVVVSKTFTTAETMLNARTVRKWLRDALGGLAVAKHMVAVS--TNLLLVNKFGIDPWNAFPFWDWVGGRYSVC 279
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499566965 212 TAVGLLPIAVS-GLA-IEDMMKGAADAREAFSTGELSENAAYQYAAI----RNILYNKGKTIellVNYEPHLHYVSEWWK 285
Cdd:PLN02649 280 SAVGLLPLSLQyGFDvVEEFLEGAASMDEHFRTAPLKENIPVLLGLLsvwnSSFLGYPARAI---LPYSQALLKFAPHIQ 356
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499566965 286 QLFGESEGK--DQKGI---YPAS-VDF----STDLHSMGQYVQDGRrNLFETVLHVEAVDKHITIEEAE--SDLDGL--N 351
Cdd:PLN02649 357 QLDMESNGKgvDLDGNplpVNTGeIDFgepgTNGQHSFYQLIHQGR-NIPCDFIGVVRSQQPVHLWLGEgvSNHDELmsN 435
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499566965 352 YLA-------GKTMDFVNKQAFKGTMLAHT--DGNVPNLVVSIPKLDEYSFGYLVYFFEKAVAMSGYLLGVNPFDQPGVE 422
Cdd:PLN02649 436 FFAqpdalayGKTPEQLRAEGVPEELIPHKvfAGNRPSLSILLPELTAYTVGQLLALYEHRVAVQGFIWNINSFDQWGVE 515
|
....
gi 499566965 423 AYKK 426
Cdd:PLN02649 516 LGKA 519
|
|
| PTZ00430 |
PTZ00430 |
glucose-6-phosphate isomerase; Provisional |
61-422 |
7.85e-31 |
|
glucose-6-phosphate isomerase; Provisional
Pssm-ID: 185612 Cd Length: 552 Bit Score: 124.74 E-value: 7.85e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499566965 61 RIQKAAEKIR------HDSDVL---LVVGIGGSYLGARAAIEALNHSFFNQLPKEKRnapQVIFVGqNISSTYLSDVLDL 131
Cdd:PTZ00430 121 RIKKFSDKIRsgeilgSTGKKLknvICIGIGGSYLGTEFVYEALRTYGEAREASKGR---KLRFLA-NVDPIDVRRATEG 196
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499566965 132 LDGKDVSVNVISKSGTTTEPAIAFRVFRDYLEKKYGKEEA-RKRIYATTdkergalktlANEEGYESFVIPDD------- 203
Cdd:PTZ00430 197 LDPEETLVVIISKTFTTAETMLNAKTVRQWLLDNIKSKEAlSKHLCAVS----------TNLKLTSEFGIPDEnvfgfwd 266
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499566965 204 -VGGRFSVLTAVGLLPIAVS-GLAIEDM-MKGAADAREAFSTGELSENAAYQYAAIRniLYN---KGKTIELLVNYEPHL 277
Cdd:PTZ00430 267 wVGGRFSVTSAVGILPLSIQfGYDIVQQfLNGCHDMDEHFRTAPLEENLPVLLGLTS--FYNstfLGYNCVAILPYCQAL 344
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499566965 278 HYVSEWWKQLFGESEGKDQKgIYPASVDFSTDL-----------HSMGQYVQDGR----------RNLFETVLHVEAVDK 336
Cdd:PTZ00430 345 LKFPAHVQQLLMESNGKSVT-LDGNTLDYNTGEiyfgepgtngqHSFYQLLHQGRvvpsefigfaKSQNPIKLLGEPVSN 423
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499566965 337 HitiEEAESDL----DGLNYlaGKTMDFVNKQAFKGTMLAHT--DGNVPNLVVSIPKLDEYSFGYLVYFFEKAVAMSGYL 410
Cdd:PTZ00430 424 H---DELMSNFfaqpDALAF--GKTYEELEKEGVPEELIPHKvfPGNRPSLLLLFPELNPYTIGQLLALYEHRTVVEGFL 498
|
410
....*....|..
gi 499566965 411 LGVNPFDQPGVE 422
Cdd:PTZ00430 499 WNINSFDQWGVE 510
|
|
| pgi |
PRK14095 |
glucose-6-phosphate isomerase; Provisional |
32-434 |
6.77e-27 |
|
glucose-6-phosphate isomerase; Provisional
Pssm-ID: 237608 Cd Length: 533 Bit Score: 113.19 E-value: 6.77e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499566965 32 KALHEKTgqgndfLGWIDLPVDYD---------KEEFARIQKAAEKIRHDSDV---------LLVVGIGGSYLGARAAIE 93
Cdd:PRK14095 98 PVLHTAT------RGQVGDSVLTDeaedmaefsKRELERLAEFLKKVRSGEIKnsngkkfttVVQIGIGGSDLGPKALYL 171
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499566965 94 ALNhsffNQLPKEKRnapqVIFVgQNISSTYLSDVLDLLDGKDVSVNVISKSGTTTEPAIAFRVFRDYLEKKygKEEARK 173
Cdd:PRK14095 172 ALK----NYAKKDKR----VHFI-SNVDPDDAAEVLSEIDLAKTLFIVVSKSGTTLETAANEEFVRDALKKA--GLDYKK 240
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499566965 174 RIYATTDKErgalKTLANEEGY-ESFVIPDDVGGRFSVLTAVGLlpiAVSGLA-----IEDMMKGAADAREAFSTGELSE 247
Cdd:PRK14095 241 HFIAVTSEG----SPMDDESGYlEVFHMWDSIGGRFSSTSMVGG---VVLGFAfgfevFKEFLKGAAAMDKAALNPNIRE 313
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499566965 248 NAAYQYAAI----RNIL---------YNKGktielLVNYEPHLhyvsewwKQLFGESEGK--DQKGIypaSVDFSTDLHS 312
Cdd:PRK14095 314 NLPLLAALIgiwnRNFLgypttavipYSQA-----LERFPAHL-------QQLDMESNGKsvNRFGE---PINFKTGPII 378
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499566965 313 MGQYVQDGRRNLFEtVLH-------VEAV-------DKHITIEEAESDlDGL--NYLA-------GKTMDFVNKQaFKgt 369
Cdd:PRK14095 379 WGEPGTNGQHSFFQ-LLHqgtdivpVEFIgfkesqlGQDIVIQGSTSQ-QKLfaNLIAqiialacGKENTNPNKN-FK-- 453
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 499566965 370 mlahtdGNVPNLVVSIPKLDEYSFGYLVYFFEKAVAMSGYLLGVNPFDQPGVEaykknmfalLGK 434
Cdd:PRK14095 454 ------GNRPSSLLVAKQLTPYTLGALLAHYENKVMFQGFCWNINSFDQEGVQ---------LGK 503
|
|
| PGI |
pfam00342 |
Phosphoglucose isomerase; Phosphoglucose isomerase catalyzes the interconversion of ... |
76-422 |
9.72e-25 |
|
Phosphoglucose isomerase; Phosphoglucose isomerase catalyzes the interconversion of glucose-6-phosphate and fructose-6-phosphate.
Pssm-ID: 395271 Cd Length: 487 Bit Score: 106.41 E-value: 9.72e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499566965 76 LLVVGIGGSYLGARAAIEALNHsffnqlpkEKRNAPQVIFVGqNISSTYLSDVLDLLDGKDVSVNVISKSGTTTEPAIAF 155
Cdd:pfam00342 99 VVNIGIGGSDLGPVMVTEALKP--------YSGRDLDVHFVS-NVDGTHIAEVLKKLNPETTLFIVASKTFTTAETMTNA 169
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499566965 156 RVFRDYLeKKYGKEE---ARKRIYATTDKErgalktLANEEGYES---FVIPDDVGGRFSVLTAVGLlPIAVS-GLAI-E 227
Cdd:pfam00342 170 ESAKEWL-LKALKDDsavAKHFIALSTNAE------KVEEFGIDTknmFEFWDWVGGRYSLWSAIGL-PIALSiGFENfQ 241
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499566965 228 DMMKGAADAREAFSTGELSENAAYqYAAIRNILYNK--GKTIELLVNYEPHLHYVSEWWKQLFGESEGK--DQKGIYpas 303
Cdd:pfam00342 242 QLLEGAHAMDKHFLSAPPEKNIPV-LLALLGVWYNNffGAQTHAILPYDQYLHRFPAYLQQLDMESNGKyvTRDGVL--- 317
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499566965 304 VDFSTDLHSMGQYVQDGRRNLFEtVLH----------VEAVDKHITIEEAESDLDGLNYLA-------GKTMDFVNKQAF 366
Cdd:pfam00342 318 VDHQTGPIIFGEPGTNGQHAFYQ-LIHqgtrlipcdfIGAVQSQNPENGDHHKILLSNFFAqtealmvGKSPEEVRKELA 396
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 499566965 367 KGT---MLAHT--DGNVPNLVVSIPKLDEYSFGYLVYFFEKAVAMSGYLLGVNPFDQPGVE 422
Cdd:pfam00342 397 AADvehLIPHKtfTGNRPSNSILVQKLTPATLGALIAMYEHKIFVQGAIWGINSFDQWGVE 457
|
|
| PRK09533 |
PRK09533 |
bifunctional transaldolase/phosoglucose isomerase; Validated |
42-425 |
1.17e-23 |
|
bifunctional transaldolase/phosoglucose isomerase; Validated
Pssm-ID: 236551 [Multi-domain] Cd Length: 948 Bit Score: 104.28 E-value: 1.17e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499566965 42 NDFLGWIDLpVDYDKEEFARIQKAAEKIRHD--SDVLlVVGIGGSYLGAraaiEALNHSFFNQL--PK----EKRNAPQV 113
Cdd:PRK09533 424 AKWLGWLDI-VEDELAHLAEYEAFAEEVRAEgfTDAV-VLGMGGSSLGP----EVLAETFGQRDgfPKlhvlDSTDPAQV 497
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499566965 114 ifvgqnissTYLSDVLDLldGKDVSVnVISKSGTTTEPAIAFRVFRDYLEKKYGkEEARKRIYATTDKerG-ALKTLANE 192
Cdd:PRK09533 498 ---------RALEAAVDL--ARTLFI-VSSKSGGTLEPNIFKDYFFARVKEVLG-AKAGRHFVAVTDP--GsSLEKVAKE 562
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499566965 193 EGYES-FVIPDDVGGRFSVLTAVGLLPIAVSGLAIEDMMKGA-ADAREAFSTGELSENAAYQYAAIRNILYNKGK---TI 267
Cdd:PRK09533 563 DGFRKiFHGDPDIGGRYSVLSPFGLVPAAAAGIDVRALLDSAlAMVRSCGPSVPPADNPGVQLGLALGVAATQGRdkvTI 642
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499566965 268 ELlvnyEPHLHYVSEWWKQLFGESEGKDQKGIYPasVDFSTdLHSMGQYVQDgrRNLFETVLHVEAVDKHitiEEAESDL 347
Cdd:PRK09533 643 VA----SPAIADFGAWAEQLIAESTGKEGKGLIP--IDGEP-LGDPAVYGND--RVFVYLRLAGEADAAQ---DAALAAL 710
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 499566965 348 DGlnylAGktmdfvnkqafkgtmlaHtdgnvPnlVVSIPKLDEYSFGYLVYFFEKAVAMSGYLLGVNPFDQPGVEAYK 425
Cdd:PRK09533 711 EA----AG-----------------H-----P--VVRIVLDSAEQLGQEFFRWEMATAVAGAVLGINPFDQPDVEASK 760
|
|
| pgi |
PRK00179 |
glucose-6-phosphate isomerase; Reviewed |
57-451 |
8.67e-21 |
|
glucose-6-phosphate isomerase; Reviewed
Pssm-ID: 234679 Cd Length: 548 Bit Score: 94.86 E-value: 8.67e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499566965 57 EEFARIQKAAEKIRHDS----------DVllV-VGIGGSYLGARAAIEALNHsffnqlpkEKRNAPQVIFVGqNISSTYL 125
Cdd:PRK00179 120 AVLARMKAFAEAVRSGEwkgytgkaitDV--VnIGIGGSDLGPVMVTEALRP--------YADPGLRVHFVS-NVDGAHL 188
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499566965 126 SDVLDLLDGKDVSVNVISKSGTTTEPAIAFRVFRDYLEKKYGKEEARKRIYAttdkergALKTlaNEEGYESFVIPDD-- 203
Cdd:PRK00179 189 AETLKKLDPETTLFIVASKTFTTQETLTNAHSARDWFLAAGGDEAAVAKHFV-------AVST--NAEAVAEFGIDPDnm 259
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499566965 204 ------VGGRFSVLTAVGlLPIAvsgLAI-----EDMMKGAADAREAFSTGELSENAAYQYAAI----RNILynkGKTIE 268
Cdd:PRK00179 260 fgfwdwVGGRYSLWSAIG-LSIA---LAIgpdnfEELLAGAHAMDEHFRTAPLEKNLPVLLALIgvwyRNFF---GAQSH 332
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499566965 269 LLVNYEPHLHYVSEWWKQLFGESEGK--DQKGiypASVDFST------DLHSMGQ--YVQdgrrnlfetVLH----VEAV 334
Cdd:PRK00179 333 AVLPYDQYLHRFPAYLQQLEMESNGKsvDRDG---TPVDYQTgpiiwgEPGTNGQhaFFQ---------LLHqgtkLVPA 400
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499566965 335 DkHITIEEAESDLDG----L--NYLA-------GKTMDFVNKQAFKGTMLAHTD----------GNVPNLVVSIPKLDEY 391
Cdd:PRK00179 401 D-FIAPAQPHNPLGDhhdlLlaNCFAqtealmfGKTAEEVRAELRAKGLDEAEAeelaphkvfpGNRPSTTILLDRLTPF 479
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|
gi 499566965 392 SFGYLVYFFEKAVAMSGYLLGVNPFDQPGVEaykknmfalLGKpgfeEEKNKLESRLTDN 451
Cdd:PRK00179 480 TLGALIALYEHKVFVQGVIWGINSFDQWGVE---------LGK----QLAKRILPELEGD 526
|
|
| SIS_TAL_PGI |
cd05798 |
SIS_TAL_PGI: Transaldolase (TAL)/ Phosphoglucose isomerase (PGI). This group represents the ... |
283-427 |
7.44e-10 |
|
SIS_TAL_PGI: Transaldolase (TAL)/ Phosphoglucose isomerase (PGI). This group represents the SIS (Sugar ISomerase) PGI domain, of a multifunctional protein (TAL-PGI ) having both TAL and PGI activities. TAL_PGI contains an N-terminal TAL domain and a C-terminal PGI domain. TAL catalyzes the reversible conversion of sedoheptulose-7-phosphate (S7P) and glyceraldehyde-3-phosphate (G3P), to fructose-6-phosphate (F6P) and erythrose-4-phosphate (E4P). PGI catalyzes the reversible isomerization of F6P to glucose-6-phosphate (G6P). It has been suggested for Gluconobacter oxydans TAL_PGI that this enzyme generates E4P and G6P directly from S7P and G3P. G. oxydans TAL_PGI contributes to increased xylitol production from D-arabitol. As xylitol is an alternative natural sweetner to sucrose, the microbial conversion of D-arabitol to xylitol is of interest to food and pharmaceutical industries.
Pssm-ID: 240224 [Multi-domain] Cd Length: 129 Bit Score: 56.69 E-value: 7.44e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499566965 283 WWKQLFGESEGKDQKGIYPasvdfsTDLHSMGQ-YVQDGRRNLFETVLHVEAVDKHitiEEAESDLDGlnylAGKTmdfv 361
Cdd:cd05798 17 WLEQLIAESTGKEGKGIIP------VDGEPLGDpAVYGDDRVFVYLRLAGEADADQ---EEALLALEA----AGHP---- 79
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 499566965 362 nkqafkgtmlahtdgnvpnlVVSIPKLDEYSFGYLVYFFEKAVAMSGYLLGVNPFDQPGVEAYKKN 427
Cdd:cd05798 80 --------------------VIRIDLDDAYDLGQEFFRWEMATAVAGAVLGINPFDQPDVEASKIE 125
|
|
| SIS |
cd04795 |
SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and ... |
76-181 |
1.72e-04 |
|
SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars.
Pssm-ID: 240112 [Multi-domain] Cd Length: 87 Bit Score: 40.05 E-value: 1.72e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499566965 76 LLVVGIGGSYLGARAAIEALNHSFfnqlpkekrnAPQVIFVGQNISSTYlsdVLDLLDGKDVSVNVISKSGTTTEPAIAF 155
Cdd:cd04795 1 IFVIGIGGSGAIAAYFALELLELT----------GIEVVALIATELEHA---SLLSLLRKGDVVIALSYSGRTEELLAAL 67
|
90 100
....*....|....*....|....*.
gi 499566965 156 RVFRDylekkygkeeARKRIYATTDK 181
Cdd:cd04795 68 EIAKE----------LGIPVIAITDA 83
|
|
| |
