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Conserved domains on  [gi|499569394|ref|WP_011250177|]
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Na+/H+ antiporter subunit E [Thermococcus kodakarensis]

Protein Classification

Na+/H+ antiporter subunit E( domain architecture ID 10014032)

Na+/H+ antiporter subunit E is part of a Na+/H+ prokaryotic antiporter complex consists of seven subunits (MrpABCDEFG), which are involved in Na+ excretion

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK12651 PRK12651
Na+/H+ antiporter subunit E;
7-177 4.96e-62

Na+/H+ antiporter subunit E;


:

Pssm-ID: 237159  Cd Length: 158  Bit Score: 188.90  E-value: 4.96e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499569394   7 ISRYLYTLIILFLIWLALTASLDQQELIFGFVLSAIVAAITYPIFttrgLANLHPKRVAYAIAYAPYFLWAMIMANLDVA 86
Cdd:PRK12651   1 MAFQLLLNIILAVLWLFLTGSFSLGNFIIGFILGLFVLFLFRRLL----PARFYLRRIYKLIKLVPIFLKELIKANIDVA 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499569394  87 YRVLHPKRPIRPGIVHCKTILKTNPGKLSLANSITLTPGTITLDVDGDD--YFIHWIWVPDEvlhaeseevhvEKASENI 164
Cdd:PRK12651  77 KIVLKPKLNIEPGIVAVPTDLKTDWEITLLANLITLTPGTLTLDVSDDRkkLYIHAIDVKDK-----------EEEIREI 145

                        170
                 ....*....|...
gi 499569394 165 TRPFEKFLKVIFG 177
Cdd:PRK12651 146 KDSFEKILLEVFE 158
 
Name Accession Description Interval E-value
PRK12651 PRK12651
Na+/H+ antiporter subunit E;
7-177 4.96e-62

Na+/H+ antiporter subunit E;


Pssm-ID: 237159  Cd Length: 158  Bit Score: 188.90  E-value: 4.96e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499569394   7 ISRYLYTLIILFLIWLALTASLDQQELIFGFVLSAIVAAITYPIFttrgLANLHPKRVAYAIAYAPYFLWAMIMANLDVA 86
Cdd:PRK12651   1 MAFQLLLNIILAVLWLFLTGSFSLGNFIIGFILGLFVLFLFRRLL----PARFYLRRIYKLIKLVPIFLKELIKANIDVA 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499569394  87 YRVLHPKRPIRPGIVHCKTILKTNPGKLSLANSITLTPGTITLDVDGDD--YFIHWIWVPDEvlhaeseevhvEKASENI 164
Cdd:PRK12651  77 KIVLKPKLNIEPGIVAVPTDLKTDWEITLLANLITLTPGTLTLDVSDDRkkLYIHAIDVKDK-----------EEEIREI 145

                        170
                 ....*....|...
gi 499569394 165 TRPFEKFLKVIFG 177
Cdd:PRK12651 146 KDSFEKILLEVFE 158
2a6301s05 TIGR00942
Monovalent Cation (K+ or Na+):Proton Antiporter-3 (CPA3) subfamily; [Transport and binding ...
 21-176 2.80e-51

Monovalent Cation (K+ or Na+):Proton Antiporter-3 (CPA3) subfamily; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 130017  Cd Length: 144  Bit Score: 161.16  E-value: 2.80e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499569394   21 WLALTASLDQQELIFGFVLSAIVAAITYPIFTTRglanLHPKRVAYAIAYAPYFLWAMIMANLDVAYRVLHPKRPIRPGI 100
Cdd:TIGR00942   1 WLFVTQSVTPGSIVLGLIFSTVLAWVTLNLQPAR----SRLHRWSRIIGFILRFLGDVIKANIDVTLIILRPRRPVNPGF 76

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 499569394  101 VHCKTILKTNPGKLSLANSITLTPGTITLDVDGDDYFIHWIWVPDEvlhaeseevHVEKASENITRPFEKFLKVIF 176
Cdd:TIGR00942  77 MTVSTDLKDENALALLANVITLTPGTAWLEYDRDRKIILFHVLDIS---------NEELWRETITRSYEKDLKEIF 143
MnhE COG1863
Multisubunit Na+/H+ antiporter, MnhE subunit [Inorganic ion transport and metabolism];
5-177 2.76e-46

Multisubunit Na+/H+ antiporter, MnhE subunit [Inorganic ion transport and metabolism];


Pssm-ID: 441468  Cd Length: 162  Bit Score: 149.16  E-value: 2.76e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499569394   5 SKISRYLYTLIILFLIWLALTASLDQQELIFGFVLSAIVAAITYPIFTTRGLanlHPKRVAYAIAYAPYFLWAMIMANLD 84
Cdd:COG1863    2 KRLLPHLLLSLLLALVWLLLSGSFSPGNLLLGLLLALLVLLLFRRLPPPRLP---YLRRPLRLLRLLLYFLWDIVVANID 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499569394  85 VAYRVLHPKRPIRPGIVHCKTILKTNPGKLSLANSITLTPGTITLDVDGDD--YFIHWIWVPDEvlhaeseevhvEKASE 162
Cdd:COG1863   79 VARRVLRPRLPIRPGIVAVPLRLRSDLGITLLANSITLTPGTLTVDVDDDRrtLYVHALDVDDP-----------EALIE 147

                        170
                 ....*....|....*
gi 499569394 163 NITRPFEKFLKVIFG 177
Cdd:COG1863  148 EIKGRYERRLLEIFE 162
MNHE pfam01899
Na+/H+ ion antiporter subunit; Subunit of a Na+/H+ Prokaryotic antiporter complex.
 14-175 1.07e-43

Na+/H+ ion antiporter subunit; Subunit of a Na+/H+ Prokaryotic antiporter complex.


Pssm-ID: 460378  Cd Length: 150  Bit Score: 141.83  E-value: 1.07e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499569394   14 LIILFLIWLALTASLDQQELIFGFVLSAIVAAITYPIFTTRGLAnlhPKRVAYAIAYAPYFLWAMIMANLDVAYRVLHPK 93
Cdd:pfam01899   1 NLLLAVVWLLLTGSFSPGNLLLGLLLGLLVLLLLRRLLPPRPPP---RRPPLGLLRLLLYFLWEIVKANIQVARLVLRPK 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499569394   94 RPIRPGIVHCKTILKTNPGKLSLANSITLTPGTITLDVDGDD--YFIHWIWVPDEvlhaeseevhvEKASENITRPFEKF 171
Cdd:pfam01899  78 PPIRPGIVAVPLRLRSDLALTLLANSITLTPGTLVVDVDRDRrvLYVHVLDVDDE-----------EAARREIKGRLERR 146


                  ....
gi 499569394  172 LKVI 175
Cdd:pfam01899 147 LLEI 150
 
Name Accession Description Interval E-value
PRK12651 PRK12651
Na+/H+ antiporter subunit E;
7-177 4.96e-62

Na+/H+ antiporter subunit E;


Pssm-ID: 237159  Cd Length: 158  Bit Score: 188.90  E-value: 4.96e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499569394   7 ISRYLYTLIILFLIWLALTASLDQQELIFGFVLSAIVAAITYPIFttrgLANLHPKRVAYAIAYAPYFLWAMIMANLDVA 86
Cdd:PRK12651   1 MAFQLLLNIILAVLWLFLTGSFSLGNFIIGFILGLFVLFLFRRLL----PARFYLRRIYKLIKLVPIFLKELIKANIDVA 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499569394  87 YRVLHPKRPIRPGIVHCKTILKTNPGKLSLANSITLTPGTITLDVDGDD--YFIHWIWVPDEvlhaeseevhvEKASENI 164
Cdd:PRK12651  77 KIVLKPKLNIEPGIVAVPTDLKTDWEITLLANLITLTPGTLTLDVSDDRkkLYIHAIDVKDK-----------EEEIREI 145

                        170
                 ....*....|...
gi 499569394 165 TRPFEKFLKVIFG 177
Cdd:PRK12651 146 KDSFEKILLEVFE 158
2a6301s05 TIGR00942
Monovalent Cation (K+ or Na+):Proton Antiporter-3 (CPA3) subfamily; [Transport and binding ...
 21-176 2.80e-51

Monovalent Cation (K+ or Na+):Proton Antiporter-3 (CPA3) subfamily; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 130017  Cd Length: 144  Bit Score: 161.16  E-value: 2.80e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499569394   21 WLALTASLDQQELIFGFVLSAIVAAITYPIFTTRglanLHPKRVAYAIAYAPYFLWAMIMANLDVAYRVLHPKRPIRPGI 100
Cdd:TIGR00942   1 WLFVTQSVTPGSIVLGLIFSTVLAWVTLNLQPAR----SRLHRWSRIIGFILRFLGDVIKANIDVTLIILRPRRPVNPGF 76

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 499569394  101 VHCKTILKTNPGKLSLANSITLTPGTITLDVDGDDYFIHWIWVPDEvlhaeseevHVEKASENITRPFEKFLKVIF 176
Cdd:TIGR00942  77 MTVSTDLKDENALALLANVITLTPGTAWLEYDRDRKIILFHVLDIS---------NEELWRETITRSYEKDLKEIF 143
MnhE COG1863
Multisubunit Na+/H+ antiporter, MnhE subunit [Inorganic ion transport and metabolism];
5-177 2.76e-46

Multisubunit Na+/H+ antiporter, MnhE subunit [Inorganic ion transport and metabolism];


Pssm-ID: 441468  Cd Length: 162  Bit Score: 149.16  E-value: 2.76e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499569394   5 SKISRYLYTLIILFLIWLALTASLDQQELIFGFVLSAIVAAITYPIFTTRGLanlHPKRVAYAIAYAPYFLWAMIMANLD 84
Cdd:COG1863    2 KRLLPHLLLSLLLALVWLLLSGSFSPGNLLLGLLLALLVLLLFRRLPPPRLP---YLRRPLRLLRLLLYFLWDIVVANID 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499569394  85 VAYRVLHPKRPIRPGIVHCKTILKTNPGKLSLANSITLTPGTITLDVDGDD--YFIHWIWVPDEvlhaeseevhvEKASE 162
Cdd:COG1863   79 VARRVLRPRLPIRPGIVAVPLRLRSDLGITLLANSITLTPGTLTVDVDDDRrtLYVHALDVDDP-----------EALIE 147

                        170
                 ....*....|....*
gi 499569394 163 NITRPFEKFLKVIFG 177
Cdd:COG1863  148 EIKGRYERRLLEIFE 162
MNHE pfam01899
Na+/H+ ion antiporter subunit; Subunit of a Na+/H+ Prokaryotic antiporter complex.
 14-175 1.07e-43

Na+/H+ ion antiporter subunit; Subunit of a Na+/H+ Prokaryotic antiporter complex.


Pssm-ID: 460378  Cd Length: 150  Bit Score: 141.83  E-value: 1.07e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499569394   14 LIILFLIWLALTASLDQQELIFGFVLSAIVAAITYPIFTTRGLAnlhPKRVAYAIAYAPYFLWAMIMANLDVAYRVLHPK 93
Cdd:pfam01899   1 NLLLAVVWLLLTGSFSPGNLLLGLLLGLLVLLLLRRLLPPRPPP---RRPPLGLLRLLLYFLWEIVKANIQVARLVLRPK 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499569394   94 RPIRPGIVHCKTILKTNPGKLSLANSITLTPGTITLDVDGDD--YFIHWIWVPDEvlhaeseevhvEKASENITRPFEKF 171
Cdd:pfam01899  78 PPIRPGIVAVPLRLRSDLALTLLANSITLTPGTLVVDVDRDRrvLYVHVLDVDDE-----------EAARREIKGRLERR 146


                  ....
gi 499569394  172 LKVI 175
Cdd:pfam01899 147 LLEI 150
PRK08383 PRK08383
putative monovalent cation/H+ antiporter subunit E; Reviewed
 10-171 7.54e-33

putative monovalent cation/H+ antiporter subunit E; Reviewed


Pssm-ID: 181407  Cd Length: 168  Bit Score: 114.90  E-value: 7.54e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499569394  10 YLYTLIILFLIWLALTAS-----LDQQELIFGFVLSAIVAAITYPIFTTRGLANLHPKRVAYAIAYA-PYFLWAMIMANL 83
Cdd:PRK08383   3 FITAFIWSYVLWLVLTAGskgllWSPEELIAGLIFAAIVGYATRNIIGEKATRFLNPIRWLLFIAYAfGPLFWGMVKANL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499569394  84 DVAYRVLHPKrpIRPGIVHCKTILKTNPGKLSLANSITLTPGTITLDVDGDD--YFIHWIWVPDEVLHAESeevhvekaS 161
Cdd:PRK08383  83 DVAYRVITGK--IRPGIVKVPVDLENDAQYTILSNSITLTPGTLTIEACPEEkaLYVHWINVPEGLEKPES--------S 152

                        170
                 ....*....|
gi 499569394 162 ENITRPFEKF 171
Cdd:PRK08383 153 EPVSGPFEKW 162
PRK12652 PRK12652
monovalent cation/H+ antiporter subunit E;
1-139 2.07e-24

monovalent cation/H+ antiporter subunit E;


Pssm-ID: 237160 [Multi-domain]  Cd Length: 357  Bit Score: 97.13  E-value: 2.07e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499569394   1 MEEASKISRYLYTLIILFLIWLALTASLDQQELIFGFVLSAIVAAITYPIFTTR--GLANLhPKRVAYAIAYAPYFLWAM 78
Cdd:PRK12652 160 LVRAATLDKFAALFGASFGFYLLLGDPLYWFDLLTGAVTALIVAVLLAHVTFSRppSLRRT-PLRVLRFLLYVPYLLWEI 238

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 499569394  79 IMANLDVAYRVLHPKRPIRPGIVHCKTILKTNPGKLSLANSITLTPGTITLDVDGDDYFIH 139
Cdd:PRK12652 239 VKANVAIAYVILHPSLPIDPTMVRVRAAVRSGLPLTTLANSITLTPGTLTVDVDDRHLLVH 299
PRK08382 PRK08382
putative monovalent cation/H+ antiporter subunit E; Reviewed
 3-176 1.79e-23

putative monovalent cation/H+ antiporter subunit E; Reviewed


Pssm-ID: 169415  Cd Length: 201  Bit Score: 91.77  E-value: 1.79e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499569394   3 EASKIS---RYLYTLIILFLIWLALTASLDQQELIFGFVLSAIVAAITYPIFT--TRGLANLHPKRVAYAIAYAPYFLWA 77
Cdd:PRK08382  25 EAQKLPpweRFVLTWLILLAFWVIISGDLSPRGLILGALTTLIIASYMRDFLTedIRRSGHLLWKILYFALIYLPQYLII 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499569394  78 M----IMANLDVAYRVLHpkRPIRPGIVHCKTILKTNPGKLSLANSITLTPGTITLDV----DGDDYFIHWIWVpdevlh 149
Cdd:PRK08382 105 MafrlLESNLKVAKHVIF--MDINPGIVKIKTDLHSDTGITILANSITLTPGTLTLDVvkklGETYLYVHWIDV------ 176

                        170       180
                 ....*....|....*....|....*..
gi 499569394 150 aesEEVHVEKASENITRPFEKFLKVIF 176
Cdd:PRK08382 177 ---ETLNREKAGEKIKGDIEEWLKKIF 200
PRK08965 PRK08965
putative monovalent cation/H+ antiporter subunit E; Reviewed
 9-177 4.32e-22

putative monovalent cation/H+ antiporter subunit E; Reviewed


Pssm-ID: 181598  Cd Length: 162  Bit Score: 87.15  E-value: 4.32e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499569394   9 RYLYTLIILFLIWLALTASLDQQELIFGFVLSAIVAAITYPIFTTRGlanlHPKRVAYAIAYAPYFLWAMIMANLDVAYR 88
Cdd:PRK08965   7 PQPLLSLWLALVWLLLNGSFSLGNLLLGLLLGLLIPLLLALLVPLEG----RLRRPLALLRLLLVVLYDLVVSNIQVAWL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499569394  89 VLHPKRPIRPGIVHCKTILKTNPGKLSLANSITLTPGTITLDVDGDD--YFIHwiwvpdeVLHAESEEvhvEKASENITR 166
Cdd:PRK08965  83 ILRPGPRPRPGFVAVPLRLRSDLALTLLANIITLTPGTVVVEISRDRrtLYVH-------VLDLDDPE---ALIREIKQR 152

                        170
                 ....*....|.
gi 499569394 167 pFEKFLKVIFG 177
Cdd:PRK08965 153 -YERLLMEIFE 162
PRK06279 PRK06279
putative monovalent cation/H+ antiporter subunit E; Reviewed
 63-134 2.54e-10

putative monovalent cation/H+ antiporter subunit E; Reviewed


Pssm-ID: 180506 [Multi-domain]  Cd Length: 100  Bit Score: 54.67  E-value: 2.54e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 499569394  63 RVAYAIAYAPYFLWAMIMANLDVAYRVLHPKrpIRPGIVHCKTILKTNPGKLSLANSITLTPGTITLDVDGD 134
Cdd:PRK06279   2 RLLYGIGYLIVLIKAIIEAWIDVVKRSLNGK--IDPEVIEIETEINRPVGQVLLANSITLTPGTLTIDLDSE 71
PRK12596 PRK12596
putative monovalent cation/H+ antiporter subunit E; Reviewed
 6-130 3.22e-04

putative monovalent cation/H+ antiporter subunit E; Reviewed


Pssm-ID: 105779  Cd Length: 171  Bit Score: 39.57  E-value: 3.22e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499569394   6 KISRYLYTLIILFLIWLALTASLDQQelifgFVLSAIVAAITYPIFTTrglanLHPKRvaYAIAYAPYFLWAM------- 78
Cdd:PRK12596   3 KILPYPLLFVSLVLFWLLLNSFTRAQ-----FILGLVIAFGACRVMMA-----LEPQK--NHIRSPRMMIWLLyaasidv 70

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 499569394  79 IMANLDVAYRVLHPKRPIRPGIVHCKTILKTNPGKLSLANSITLTPGTITLD 130
Cdd:PRK12596  71 LRSNIAVVRLILSPGRQRHPGFVVIPLELQNRTALAVLACMITASPGTAWVD 122
PRK06580 PRK06580
putative monovalent cation/H+ antiporter subunit E; Reviewed
 68-139 8.31e-03

putative monovalent cation/H+ antiporter subunit E; Reviewed


Pssm-ID: 180628  Cd Length: 103  Bit Score: 34.46  E-value: 8.31e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 499569394  68 IAYAPYFLWAMIMANLDVAYRVLHPKRPIRPGIVHCKTILKTNPGKLSLANSITLTPGTITLDVDGDDYFIH 139
Cdd:PRK06580  10 ILYFPWLLLEIWKSAFSVIKIIWQRKIGIEPVFEWVDAEGLEEIGEIIYGNSITLTPGTVTLDINNNMLLVH 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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