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Conserved domains on  [gi|499628775|ref|WP_011309509|]
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MULTISPECIES: response regulator transcription factor [Dehalococcoides]

Protein Classification

response regulator transcription factor( domain architecture ID 10361306)

response regulator transcription factor with a signal receiver (REC) domain and an ArsR family helix-turn-helix (HTH) domain that may be part of a two-component regulatory system

CATH:  3.40.50.2300
Gene Ontology:  GO:0000160|GO:0000156|GO:0006355|GO:0003677|GO:0003700|GO:0007165
PubMed:  15808743|19076237|10473770|8831795|10966457|20226724
SCOP:  4003632

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
trans_reg_C cd00383
DNA-binding effector domain of two-component system response regulators; Bacteria and some ...
 132-219 3.27e-36

DNA-binding effector domain of two-component system response regulators; Bacteria and some eukaryotes use two-component signal transduction systems to detect and respond to changes in the environment. The systems consists of a sensor histidine kinase and a response regulator. The former autophosphorylates a histidine residue on detecting an external stimulus. The phosphate is then transferred to an invariant aspartate residue in a highly conserved receiver domain of the response regulator. Phosphorylation activates a variable effector domain of the response regulator, which triggers the cellular response. This C-terminal effector domain belongs to the winged helix-turn-helix family of transcriptional regulators and contains DNA and RNA polymerase binding sites. Several dimers or monomers bind head to tail to small tandem repeats upstream of the genes. The RNA polymerase binding sites interact with the alpha or sigma subunit of RNA polymerase.


:

Pssm-ID: 294013 [Multi-domain]  Cd Length: 89  Bit Score: 122.59  E-value: 3.27e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499628775 132 LIIDTLGCEVTLAGQLLELTFREFELLKFLAQNRGRVFSREALLNKVWGYDYYGGDRTVDVHITRLRGKIE-DSTHTFVE 210
Cdd:cd00383    1 LRLDPARREVTVDGEEVELTPKEFELLELLARNPGRVVSREELLEAVWGYDYEVDDRTVDVHISRLRKKLEdDPEPRLIK 80


                 ....*....
gi 499628775 211 TVRNIGYRF 219
Cdd:cd00383   81 TVRGVGYRL 89
REC super family cl19078
phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response ...
 21-219 5.82e-33

phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs); Two-component systems (TCSs) involving a sensor and a response regulator are used by bacteria to adapt to changing environments. Processes regulated by two-component systems in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Response regulators (RRs) share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. Response regulators regulate transcription, post-transcription or post-translation, or have functions such as methylesterases, adenylate or diguanylate cyclase, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases, and protein phosphatases, depending on their output domains. The function of some output domains are still unknown. TCSs are found in all three domains of life - bacteria, archaea, and eukaryotes, however, the presence and abundance of particular RRs vary between the lineages. Archaea encode very few RRs with DNA-binding output domains; most are stand-alone REC domains. Among eukaryotes, TCSs are found primarily in protozoa, fungi, algae, and green plants. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


The actual alignment was detected with superfamily member TIGR02154:

Pssm-ID: 473134 [Multi-domain]  Cd Length: 226  Bit Score: 118.59  E-value: 5.82e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499628775   21 LEADRFEIKQAVSCVLAYPSLFEFAPDIILLDFL-----------SLKAEQSEWEIPediqldknpLVMglLPADDYED- 88
Cdd:TIGR02154  22 LEKAGYDVVEAGDGDEALTLINERGPDLILLDWMlpgtsgielcrRLRRRPETRAIP---------IIM--LTARGEEEd 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499628775   89 --IALKPGLDDFIRWPGSVNELKVRL-ARLAEKWGMGEPGIIKAGDLIIDTLGCEVTLAGQLLELTFREFELLKFLAQNR 165
Cdd:TIGR02154  91 rvRGLETGADDYITKPFSPRELLARIkAVLRRIRPQLSDEVIEVGDLSLDPVAHRVFRGGQPLSLGPTEFRLLHFFMTHP 170

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 499628775  166 GRVFSREALLNKVWGYDYYGGDRTVDVHITRLRGKIEDSTHT-FVETVRNIGYRF 219
Cdd:TIGR02154 171 ERVYSREQLLDRVWGRDVYVEERTVDVHIRRLRKALNPFGLEdPVQTVRGAGYRF 225
 
Name Accession Description Interval E-value
trans_reg_C cd00383
DNA-binding effector domain of two-component system response regulators; Bacteria and some ...
 132-219 3.27e-36

DNA-binding effector domain of two-component system response regulators; Bacteria and some eukaryotes use two-component signal transduction systems to detect and respond to changes in the environment. The systems consists of a sensor histidine kinase and a response regulator. The former autophosphorylates a histidine residue on detecting an external stimulus. The phosphate is then transferred to an invariant aspartate residue in a highly conserved receiver domain of the response regulator. Phosphorylation activates a variable effector domain of the response regulator, which triggers the cellular response. This C-terminal effector domain belongs to the winged helix-turn-helix family of transcriptional regulators and contains DNA and RNA polymerase binding sites. Several dimers or monomers bind head to tail to small tandem repeats upstream of the genes. The RNA polymerase binding sites interact with the alpha or sigma subunit of RNA polymerase.


Pssm-ID: 294013 [Multi-domain]  Cd Length: 89  Bit Score: 122.59  E-value: 3.27e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499628775 132 LIIDTLGCEVTLAGQLLELTFREFELLKFLAQNRGRVFSREALLNKVWGYDYYGGDRTVDVHITRLRGKIE-DSTHTFVE 210
Cdd:cd00383    1 LRLDPARREVTVDGEEVELTPKEFELLELLARNPGRVVSREELLEAVWGYDYEVDDRTVDVHISRLRKKLEdDPEPRLIK 80


                 ....*....
gi 499628775 211 TVRNIGYRF 219
Cdd:cd00383   81 TVRGVGYRL 89
PhoB TIGR02154
phosphate regulon transcriptional regulatory protein PhoB; PhoB is a DNA-binding response ...
 21-219 5.82e-33

phosphate regulon transcriptional regulatory protein PhoB; PhoB is a DNA-binding response regulator protein acting with PhoR in a 2-component system responding to phosphate ion. PhoB acts as a positive regulator of gene expression for phosphate-related genes such as phoA, phoS, phoE and ugpAB as well as itself. It is often found proximal to genes for the high-affinity phosphate ABC transporter (pstSCAB; GenProp0190) and presumably regulates these as well. [Regulatory functions, DNA interactions, Signal transduction, Two-component systems]


Pssm-ID: 131209 [Multi-domain]  Cd Length: 226  Bit Score: 118.59  E-value: 5.82e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499628775   21 LEADRFEIKQAVSCVLAYPSLFEFAPDIILLDFL-----------SLKAEQSEWEIPediqldknpLVMglLPADDYED- 88
Cdd:TIGR02154  22 LEKAGYDVVEAGDGDEALTLINERGPDLILLDWMlpgtsgielcrRLRRRPETRAIP---------IIM--LTARGEEEd 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499628775   89 --IALKPGLDDFIRWPGSVNELKVRL-ARLAEKWGMGEPGIIKAGDLIIDTLGCEVTLAGQLLELTFREFELLKFLAQNR 165
Cdd:TIGR02154  91 rvRGLETGADDYITKPFSPRELLARIkAVLRRIRPQLSDEVIEVGDLSLDPVAHRVFRGGQPLSLGPTEFRLLHFFMTHP 170

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 499628775  166 GRVFSREALLNKVWGYDYYGGDRTVDVHITRLRGKIEDSTHT-FVETVRNIGYRF 219
Cdd:TIGR02154 171 ERVYSREQLLDRVWGRDVYVEERTVDVHIRRLRKALNPFGLEdPVQTVRGAGYRF 225
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
 1-203 2.38e-32

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 116.21  E-value: 2.38e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499628775   1 MLKLFIVTaDAKKNGNLLKE-LEADRFEIKQAVSCVLAYPSLFEFAPDIILLDfLSLkAEQSEWEIPEDIQLDKN--PLV 77
Cdd:COG0745    1 MPRILVVE-DDPDIRELLADaLEREGYEVDTAADGEEALELLEEERPDLILLD-LML-PGMDGLEVCRRLRARPSdiPII 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499628775  78 MglLPA-DDYEDI--ALKPGLDDFIRWPGSVNELKVRLARLAEKwgmGEPGIIKAGDLIiDTLGCEVTLAGQLLELTFRE 154
Cdd:COG0745   78 M--LTArDDEEDRvrGLEAGADDYLTKPFDPEELLARIRALLRR---RAAEVLRVGDLL-DLAAREVTRDGEPVELTPKE 151

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 499628775 155 FELLKFLAQNRGRVFSREALLNKVWGYDyYGGDRTVDVHITRLRGKIED 203
Cdd:COG0745  152 FRLLELLMRNPGRVVSREQLLEEVWGYD-YGDDRTVDVHISRLRKKLED 199
Trans_reg_C pfam00486
Transcriptional regulatory protein, C terminal;
145-219 3.54e-32

Transcriptional regulatory protein, C terminal;


Pssm-ID: 425712 [Multi-domain]  Cd Length: 77  Bit Score: 111.84  E-value: 3.54e-32
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 499628775  145 GQLLELTFREFELLKFLAQNRGRVFSREALLNKVWGYDYYGGDRTVDVHITRLRGKIEDSTH--TFVETVRNIGYRF 219
Cdd:pfam00486   1 GEEVELTPKEFKLLELLAENPGRVVSREQLLEEVWGEDYDVDDNTVDVHISRLRKKLEDDPRdpRLIKTVRGVGYRL 77
Trans_reg_C smart00862
Transcriptional regulatory protein, C terminal; This domain is almost always found associated ...
 145-219 3.11e-31

Transcriptional regulatory protein, C terminal; This domain is almost always found associated with the response regulator receiver domain. It may play a role in DNA binding.


Pssm-ID: 214866 [Multi-domain]  Cd Length: 76  Bit Score: 109.56  E-value: 3.11e-31
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 499628775   145 GQLLELTFREFELLKFLAQNRGRVFSREALLNKVWGYDYYGGDRTVDVHITRLRGKIED-STHTFVETVRNIGYRF 219
Cdd:smart00862   1 GEPIKLTPKEFRLLELLLRNPGRVVSREELLEAVWGDDEDVDDNTLDVHISRLRKKLEDdGDPRLIETVRGVGYRL 76
resp_reg_YycF NF040534
response regulator YycF;
3-220 4.12e-29

response regulator YycF;


Pssm-ID: 439744 [Multi-domain]  Cd Length: 231  Bit Score: 108.65  E-value: 4.12e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499628775   3 KLFIVTADAKKNGNLLK-ELEADRFEIKQAVSCVLAYPSLFEFAPDIILLDFLSlkAEQSEWEIPEDIQLDKN-PLVMgl 80
Cdd:NF040534   1 KKILVVDDEKPIADILEfNLKKEGYEVFCAYDGNEALELVEEEVPDLVLLDIML--PGRDGMEVCREVRKKYDmPIIM-- 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499628775  81 LPADDYED---IALKPGLDDFIRWPGSVNEL----KVRLARL---AEKWGMGEPGIIKAGDLIIDTLGCEVTLAGQLLEL 150
Cdd:NF040534  77 LTAKDSEIdkvLGLELGADDYVTKPFSTRELiarvKANLRRHqqqNTEEEEEENNEIVIGSLTIHPDAYTVKKRGETIEL 156

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 499628775 151 TFREFELLKFLAQNRGRVFSREALLNKVWGYDYYGGDRTVDVHITRLRGKIED--STHTFVETVRNIGYRFK 220
Cdd:NF040534 157 THREFELLHYLAKHIGQVMTREHLLQTVWGYDYFGDVRTVDVTVRRLREKIEDnpSHPEWIVTRRGVGYYLR 228
PRK10161 PRK10161
phosphate response regulator transcription factor PhoB;
21-223 7.11e-26

phosphate response regulator transcription factor PhoB;


Pssm-ID: 182277 [Multi-domain]  Cd Length: 229  Bit Score: 100.18  E-value: 7.11e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499628775  21 LEADRFEIKQAVSCVLAYPSLFEFAPDIILLDFLSLKAEQSEW--EIPEDIQLDKNPLVMGLLPADDYEDI-ALKPGLDD 97
Cdd:PRK10161  22 LEQNGFQPVEAEDYDSAVNQLNEPWPDLILLDWMLPGGSGIQFikHLKRESMTRDIPVVMLTARGEEEDRVrGLETGADD 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499628775  98 FIRWPGSVNELKVRLARLAEKWG-MGEPGIIKAGDLIIDTLGCEVTLAGQLLELTFREFELLKFLAQNRGRVFSREALLN 176
Cdd:PRK10161 102 YITKPFSPKELVARIKAVMRRISpMAVEEVIEMQGLSLDPTSHRVMAGEEPLEMGPTEFKLLHFFMTHPERVYSREQLLN 181

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 499628775 177 KVWGYDYYGGDRTVDVHITRLRGKIEDSTHT-FVETVRNIGYRFKRRF 223
Cdd:PRK10161 182 HVWGTNVYVEDRTVDVHIRRLRKALEPGGHDrMVQTVRGTGYRFSTRF 229
PRK10710 PRK10710
DNA-binding transcriptional regulator BaeR; Provisional
 91-218 1.37e-22

DNA-binding transcriptional regulator BaeR; Provisional


Pssm-ID: 182665 [Multi-domain]  Cd Length: 240  Bit Score: 91.67  E-value: 1.37e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499628775  91 LKPGLDDFIRWPGSVNELKVRLARLAE--KWGMGEPGIIKAGDLIIDTLGCEVTLAGQLLELTFREFELLKFLAQNRGRV 168
Cdd:PRK10710 100 LEIGADDYICKPYSPREVVARVKTILRrcKPQRELQQQDAESPLIIDESRFQASWRGKMLDLTPAEFRLLKTLSHEPGKV 179

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 499628775 169 FSREALLNKVwgYDYYG--GDRTVDVHITRLRGKIE--DSTHTFVETVRNIGYR 218
Cdd:PRK10710 180 FSREQLLNHL--YDDYRvvTDRTIDSHIKNLRRKLEslDAEQSFIRAVYGVGYR 231
CadC1 COG3710
DNA-binding winged helix-turn-helix (wHTH) domain [Transcription];
130-219 1.32e-21

DNA-binding winged helix-turn-helix (wHTH) domain [Transcription];


Pssm-ID: 442924 [Multi-domain]  Cd Length: 106  Bit Score: 85.34  E-value: 1.32e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499628775 130 GDLIIDTLGCEVTLAGQLLELTFREFELLKFLAQNRGRVFSREALLNKVWGyDYYGGDRTVDVHITRLRGKIEDS--THT 207
Cdd:COG3710    6 GDFRLDPARRELLRDGEPVRLSPRAFDLLLLLLEHPGRVVSRDELLAAVWP-GRVVSDNSLTQAISRLRKALGDDglEPR 84

                         90
                 ....*....|..
gi 499628775 208 FVETVRNIGYRF 219
Cdd:COG3710   85 LIRTVPRRGYRL 96
REC_OmpR_YycF-like cd17614
phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF ...
 6-112 3.88e-03

phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF appears to play an important role in cell wall integrity in a wide range of gram-positive bacteria, and may also modulate cell membrane integrity. It functions as part of a phosphotransfer system that ultimately controls the levels of competence within the bacteria. YycF belongs to the OmpR family of response regulators, which are characterized by a REC domain and a winged helix-turn-helix effector domain involved in DNA binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381130 [Multi-domain]  Cd Length: 115  Bit Score: 35.86  E-value: 3.88e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499628775   6 IVTADAKKNGNLLK-ELEADRFEIKQAVSCVLAYPSLFEFAPDIILLDFlsLKAEQSEWEIPEDIQLDKN-PLVMglLPA 83
Cdd:cd17614    2 LVVDDEKPISDILKfNLTKEGYEVVTAYDGREALEKVEEEQPDLILLDL--MLPEKDGLEVCREVRKTSNvPIIM--LTA 77

                         90       100       110
                 ....*....|....*....|....*....|..
gi 499628775  84 DDYE---DIALKPGLDDFIRWPGSVNELKVRL 112
Cdd:cd17614   78 KDSEvdkVLGLELGADDYVTKPFSNRELLARV 109
 
Name Accession Description Interval E-value
trans_reg_C cd00383
DNA-binding effector domain of two-component system response regulators; Bacteria and some ...
 132-219 3.27e-36

DNA-binding effector domain of two-component system response regulators; Bacteria and some eukaryotes use two-component signal transduction systems to detect and respond to changes in the environment. The systems consists of a sensor histidine kinase and a response regulator. The former autophosphorylates a histidine residue on detecting an external stimulus. The phosphate is then transferred to an invariant aspartate residue in a highly conserved receiver domain of the response regulator. Phosphorylation activates a variable effector domain of the response regulator, which triggers the cellular response. This C-terminal effector domain belongs to the winged helix-turn-helix family of transcriptional regulators and contains DNA and RNA polymerase binding sites. Several dimers or monomers bind head to tail to small tandem repeats upstream of the genes. The RNA polymerase binding sites interact with the alpha or sigma subunit of RNA polymerase.


Pssm-ID: 294013 [Multi-domain]  Cd Length: 89  Bit Score: 122.59  E-value: 3.27e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499628775 132 LIIDTLGCEVTLAGQLLELTFREFELLKFLAQNRGRVFSREALLNKVWGYDYYGGDRTVDVHITRLRGKIE-DSTHTFVE 210
Cdd:cd00383    1 LRLDPARREVTVDGEEVELTPKEFELLELLARNPGRVVSREELLEAVWGYDYEVDDRTVDVHISRLRKKLEdDPEPRLIK 80


                 ....*....
gi 499628775 211 TVRNIGYRF 219
Cdd:cd00383   81 TVRGVGYRL 89
PhoB TIGR02154
phosphate regulon transcriptional regulatory protein PhoB; PhoB is a DNA-binding response ...
 21-219 5.82e-33

phosphate regulon transcriptional regulatory protein PhoB; PhoB is a DNA-binding response regulator protein acting with PhoR in a 2-component system responding to phosphate ion. PhoB acts as a positive regulator of gene expression for phosphate-related genes such as phoA, phoS, phoE and ugpAB as well as itself. It is often found proximal to genes for the high-affinity phosphate ABC transporter (pstSCAB; GenProp0190) and presumably regulates these as well. [Regulatory functions, DNA interactions, Signal transduction, Two-component systems]


Pssm-ID: 131209 [Multi-domain]  Cd Length: 226  Bit Score: 118.59  E-value: 5.82e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499628775   21 LEADRFEIKQAVSCVLAYPSLFEFAPDIILLDFL-----------SLKAEQSEWEIPediqldknpLVMglLPADDYED- 88
Cdd:TIGR02154  22 LEKAGYDVVEAGDGDEALTLINERGPDLILLDWMlpgtsgielcrRLRRRPETRAIP---------IIM--LTARGEEEd 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499628775   89 --IALKPGLDDFIRWPGSVNELKVRL-ARLAEKWGMGEPGIIKAGDLIIDTLGCEVTLAGQLLELTFREFELLKFLAQNR 165
Cdd:TIGR02154  91 rvRGLETGADDYITKPFSPRELLARIkAVLRRIRPQLSDEVIEVGDLSLDPVAHRVFRGGQPLSLGPTEFRLLHFFMTHP 170

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 499628775  166 GRVFSREALLNKVWGYDYYGGDRTVDVHITRLRGKIEDSTHT-FVETVRNIGYRF 219
Cdd:TIGR02154 171 ERVYSREQLLDRVWGRDVYVEERTVDVHIRRLRKALNPFGLEdPVQTVRGAGYRF 225
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
 1-203 2.38e-32

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 116.21  E-value: 2.38e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499628775   1 MLKLFIVTaDAKKNGNLLKE-LEADRFEIKQAVSCVLAYPSLFEFAPDIILLDfLSLkAEQSEWEIPEDIQLDKN--PLV 77
Cdd:COG0745    1 MPRILVVE-DDPDIRELLADaLEREGYEVDTAADGEEALELLEEERPDLILLD-LML-PGMDGLEVCRRLRARPSdiPII 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499628775  78 MglLPA-DDYEDI--ALKPGLDDFIRWPGSVNELKVRLARLAEKwgmGEPGIIKAGDLIiDTLGCEVTLAGQLLELTFRE 154
Cdd:COG0745   78 M--LTArDDEEDRvrGLEAGADDYLTKPFDPEELLARIRALLRR---RAAEVLRVGDLL-DLAAREVTRDGEPVELTPKE 151

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 499628775 155 FELLKFLAQNRGRVFSREALLNKVWGYDyYGGDRTVDVHITRLRGKIED 203
Cdd:COG0745  152 FRLLELLMRNPGRVVSREQLLEEVWGYD-YGDDRTVDVHISRLRKKLED 199
Trans_reg_C pfam00486
Transcriptional regulatory protein, C terminal;
145-219 3.54e-32

Transcriptional regulatory protein, C terminal;


Pssm-ID: 425712 [Multi-domain]  Cd Length: 77  Bit Score: 111.84  E-value: 3.54e-32
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 499628775  145 GQLLELTFREFELLKFLAQNRGRVFSREALLNKVWGYDYYGGDRTVDVHITRLRGKIEDSTH--TFVETVRNIGYRF 219
Cdd:pfam00486   1 GEEVELTPKEFKLLELLAENPGRVVSREQLLEEVWGEDYDVDDNTVDVHISRLRKKLEDDPRdpRLIKTVRGVGYRL 77
Trans_reg_C smart00862
Transcriptional regulatory protein, C terminal; This domain is almost always found associated ...
 145-219 3.11e-31

Transcriptional regulatory protein, C terminal; This domain is almost always found associated with the response regulator receiver domain. It may play a role in DNA binding.


Pssm-ID: 214866 [Multi-domain]  Cd Length: 76  Bit Score: 109.56  E-value: 3.11e-31
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 499628775   145 GQLLELTFREFELLKFLAQNRGRVFSREALLNKVWGYDYYGGDRTVDVHITRLRGKIED-STHTFVETVRNIGYRF 219
Cdd:smart00862   1 GEPIKLTPKEFRLLELLLRNPGRVVSREELLEAVWGDDEDVDDNTLDVHISRLRKKLEDdGDPRLIETVRGVGYRL 76
resp_reg_YycF NF040534
response regulator YycF;
3-220 4.12e-29

response regulator YycF;


Pssm-ID: 439744 [Multi-domain]  Cd Length: 231  Bit Score: 108.65  E-value: 4.12e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499628775   3 KLFIVTADAKKNGNLLK-ELEADRFEIKQAVSCVLAYPSLFEFAPDIILLDFLSlkAEQSEWEIPEDIQLDKN-PLVMgl 80
Cdd:NF040534   1 KKILVVDDEKPIADILEfNLKKEGYEVFCAYDGNEALELVEEEVPDLVLLDIML--PGRDGMEVCREVRKKYDmPIIM-- 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499628775  81 LPADDYED---IALKPGLDDFIRWPGSVNEL----KVRLARL---AEKWGMGEPGIIKAGDLIIDTLGCEVTLAGQLLEL 150
Cdd:NF040534  77 LTAKDSEIdkvLGLELGADDYVTKPFSTRELiarvKANLRRHqqqNTEEEEEENNEIVIGSLTIHPDAYTVKKRGETIEL 156

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 499628775 151 TFREFELLKFLAQNRGRVFSREALLNKVWGYDYYGGDRTVDVHITRLRGKIED--STHTFVETVRNIGYRFK 220
Cdd:NF040534 157 THREFELLHYLAKHIGQVMTREHLLQTVWGYDYFGDVRTVDVTVRRLREKIEDnpSHPEWIVTRRGVGYYLR 228
PRK10161 PRK10161
phosphate response regulator transcription factor PhoB;
21-223 7.11e-26

phosphate response regulator transcription factor PhoB;


Pssm-ID: 182277 [Multi-domain]  Cd Length: 229  Bit Score: 100.18  E-value: 7.11e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499628775  21 LEADRFEIKQAVSCVLAYPSLFEFAPDIILLDFLSLKAEQSEW--EIPEDIQLDKNPLVMGLLPADDYEDI-ALKPGLDD 97
Cdd:PRK10161  22 LEQNGFQPVEAEDYDSAVNQLNEPWPDLILLDWMLPGGSGIQFikHLKRESMTRDIPVVMLTARGEEEDRVrGLETGADD 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499628775  98 FIRWPGSVNELKVRLARLAEKWG-MGEPGIIKAGDLIIDTLGCEVTLAGQLLELTFREFELLKFLAQNRGRVFSREALLN 176
Cdd:PRK10161 102 YITKPFSPKELVARIKAVMRRISpMAVEEVIEMQGLSLDPTSHRVMAGEEPLEMGPTEFKLLHFFMTHPERVYSREQLLN 181

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 499628775 177 KVWGYDYYGGDRTVDVHITRLRGKIEDSTHT-FVETVRNIGYRFKRRF 223
Cdd:PRK10161 182 HVWGTNVYVEDRTVDVHIRRLRKALEPGGHDrMVQTVRGTGYRFSTRF 229
orf27 CHL00148
Ycf27; Reviewed
 41-221 1.07e-24

Ycf27; Reviewed


Pssm-ID: 214376 [Multi-domain]  Cd Length: 240  Bit Score: 97.48  E-value: 1.07e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499628775  41 LFEFAPDIILLDFLSLKAEQseWEIPEDIQLDKN-PLVMgLLPADDYED--IALKPGLDDFIRWPGSVNELKVRLA---- 113
Cdd:CHL00148  46 FRKEQPDLVILDVMMPKLDG--YGVCQEIRKESDvPIIM-LTALGDVSDriTGLELGADDYVVKPFSPKELEARIRsvlr 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499628775 114 ---RLAEKWGMGEPGIIKAGDLIIDTLGCEVTLAGQLLELTFREFELLKFLAQNRGRVFSREALLNKVWGYDY--YGGDR 188
Cdd:CHL00148 123 rtnKKSFSSKIPNSSIIRIGFLKIDLNKKQVYKNNERIRLTGMEFSLLELLISKSGEIFSRATILKEVWGYTPerHIDTR 202

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 499628775 189 TVDVHITRLRGKIED--STHTFVETVRNIGYRFKR 221
Cdd:CHL00148 203 VVDVHISRLRAKLEDdpSNPDLILTARGTGYLFQS 237
PRK10710 PRK10710
DNA-binding transcriptional regulator BaeR; Provisional
 91-218 1.37e-22

DNA-binding transcriptional regulator BaeR; Provisional


Pssm-ID: 182665 [Multi-domain]  Cd Length: 240  Bit Score: 91.67  E-value: 1.37e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499628775  91 LKPGLDDFIRWPGSVNELKVRLARLAE--KWGMGEPGIIKAGDLIIDTLGCEVTLAGQLLELTFREFELLKFLAQNRGRV 168
Cdd:PRK10710 100 LEIGADDYICKPYSPREVVARVKTILRrcKPQRELQQQDAESPLIIDESRFQASWRGKMLDLTPAEFRLLKTLSHEPGKV 179

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 499628775 169 FSREALLNKVwgYDYYG--GDRTVDVHITRLRGKIE--DSTHTFVETVRNIGYR 218
Cdd:PRK10710 180 FSREQLLNHL--YDDYRvvTDRTIDSHIKNLRRKLEslDAEQSFIRAVYGVGYR 231
CadC1 COG3710
DNA-binding winged helix-turn-helix (wHTH) domain [Transcription];
130-219 1.32e-21

DNA-binding winged helix-turn-helix (wHTH) domain [Transcription];


Pssm-ID: 442924 [Multi-domain]  Cd Length: 106  Bit Score: 85.34  E-value: 1.32e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499628775 130 GDLIIDTLGCEVTLAGQLLELTFREFELLKFLAQNRGRVFSREALLNKVWGyDYYGGDRTVDVHITRLRGKIEDS--THT 207
Cdd:COG3710    6 GDFRLDPARRELLRDGEPVRLSPRAFDLLLLLLEHPGRVVSRDELLAAVWP-GRVVSDNSLTQAISRLRKALGDDglEPR 84

                         90
                 ....*....|..
gi 499628775 208 FVETVRNIGYRF 219
Cdd:COG3710   85 LIRTVPRRGYRL 96
PRK10701 PRK10701
DNA-binding transcriptional regulator RstA; Provisional
 130-219 1.13e-18

DNA-binding transcriptional regulator RstA; Provisional


Pssm-ID: 236738 [Multi-domain]  Cd Length: 240  Bit Score: 81.22  E-value: 1.13e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499628775 130 GDLIIDTLGCEVTLAGQLLELTFREFELLKFLAQNRGRVFSREALLNKVWGYDYYGGDRTVDVHITRLRGKIEDSTH--T 207
Cdd:PRK10701 142 GTLTIDPVNRQVTLAGEEISLSTADFDLLWELATHAGQIMDRDALLKNLRGVSYDGLDRSVDVAISRLRKKLLDNAAepY 221

                         90
                 ....*....|..
gi 499628775 208 FVETVRNIGYRF 219
Cdd:PRK10701 222 RIKTVRNKGYLF 233
PRK11083 PRK11083
DNA-binding response regulator CreB; Provisional
 89-217 1.21e-18

DNA-binding response regulator CreB; Provisional


Pssm-ID: 236838 [Multi-domain]  Cd Length: 228  Bit Score: 80.78  E-value: 1.21e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499628775  89 IALKPGLDDFIRWPGSVNEL----KVRLARLAeKWGMGEPGIiKAGDLIIDTLGCEVTLAGQLLELTFREFELLKFLAQN 164
Cdd:PRK11083  92 VGLEIGADDYVAKPFSPREVaarvRTILRRVK-KFAAPSPVI-RIGHFELDEPAARISYFGTPLTLTRYEFLLLKTLLLS 169

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 499628775 165 RGRVFSREALLNKVWGYDYYGGDRTVDVHITRLRGKIE--DSTHTFVETVRNIGY 217
Cdd:PRK11083 170 PGRVFSRQQLMDIVWEDAQDSYDRTVDTHIKTLRAKLRaiNPDLSPINTHRGMGY 224
PRK09836 PRK09836
DNA-binding transcriptional activator CusR; Provisional
 2-217 2.17e-16

DNA-binding transcriptional activator CusR; Provisional


Pssm-ID: 182102 [Multi-domain]  Cd Length: 227  Bit Score: 74.96  E-value: 2.17e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499628775   2 LKLFIVTADAKKNGNLLKELEADRFEIKQAVSCVLAYPSLFEFAPDIILLDFLSlkAEQSEWEIPEDIQLDKNPLVMGLL 81
Cdd:PRK09836   1 MKLLIVEDEKKTGEYLTKGLTEAGFVVDLADNGLNGYHLAMTGDYDLIILDIML--PDVNGWDIVRMLRSANKGMPILLL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499628775  82 PA---DDYEDIALKPGLDDFIRWPGSVNELKVRLARLAEKwgmGEPGIIKA----GDLIIDTLGCEVTLAGQLLELTFRE 154
Cdd:PRK09836  79 TAlgtIEHRVKGLELGADDYLVKPFAFAELLARVRTLLRR---GAAVIIESqfqvADLMVDLVSRKVTRSGTRITLTSKE 155

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 499628775 155 FELLKFLAQNRGRVFSREALLNKVWGYDYYGGDRTVDVHITRLRGKIE-DSTHTFVETVRNIGY 217
Cdd:PRK09836 156 FTLLEFFLRHQGEVLPRSLIASQVWDMNFDSDTNAIDVAVKRLRGKIDnDFEPKLIQTVRGVGY 219
PRK11517 PRK11517
DNA-binding response regulator HprR;
63-220 1.50e-15

DNA-binding response regulator HprR;


Pssm-ID: 183172 [Multi-domain]  Cd Length: 223  Bit Score: 72.62  E-value: 1.50e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499628775  63 WEIPEDIQLDKNPLVMGLLPADDYED--IALKPGLDDFIRWPGSVNELkvrLARLAEKWGMGEP--GIIKAGDLIIDTLG 138
Cdd:PRK11517  60 WQILQTLRTAKQTPVICLTARDSVDDrvRGLDSGANDYLVKPFSFSEL---LARVRAQLRQHHAlnSTLEISGLRMDSVS 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499628775 139 CEVTLAGQLLELTFREFELLKFLAQNRGRVFSREALLNKVWGYDYYGGDRTVDVHITRLRGKIEDS-THTFVETVRNIGY 217
Cdd:PRK11517 137 QSVSRDNISITLTRKEFQLLWLLASRAGEIIPRTVIASEIWGINFDSDTNTVDVAIRRLRAKVDDPfPEKLIATIRGMGY 216


                 ...
gi 499628775 218 RFK 220
Cdd:PRK11517 217 SFV 219
PRK10955 PRK10955
envelope stress response regulator transcription factor CpxR;
1-217 8.47e-15

envelope stress response regulator transcription factor CpxR;


Pssm-ID: 182864 [Multi-domain]  Cd Length: 232  Bit Score: 70.60  E-value: 8.47e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499628775   1 MLKLFIVTADaKKNGNLLKEL-EADRFEIKQAVSCVLAYpSLFEFAPDIILLDFLSLKAEQSEwEIPEDIQLDKNPLVMG 79
Cdd:PRK10955   1 MNKILLVDDD-RELTSLLKELlEMEGFNVIVAHDGEQAL-DLLDDSIDLLLLDVMMPKKNGID-TLKELRQTHQTPVIML 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499628775  80 LLPADDYEDI-ALKPGLDDFIRWPGSVNELKVRLARLAEKWGMGE---PGIIKAGDLIIDTLGC-----EVTLAGQLLEL 150
Cdd:PRK10955  78 TARGSELDRVlGLELGADDYLPKPFNDRELVARIRAILRRSHWSEqqqNNDNGSPTLEVDALSLnpgrqEASFDGQTLEL 157

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 499628775 151 TFREFELLKFLAQNRGRVFSREALLNKVWGYDYYGGDRTVDVHITRLRGKIEDST--HTFVETVRNIGY 217
Cdd:PRK10955 158 TGTEFTLLYLLAQHLGQVVSREHLSQEVLGKRLTPFDRAIDMHISNLRRKLPDRKdgHPWFKTLRGRGY 226
PRK10529 PRK10529
DNA-binding transcriptional activator KdpE; Provisional
 46-219 3.09e-14

DNA-binding transcriptional activator KdpE; Provisional


Pssm-ID: 182522 [Multi-domain]  Cd Length: 225  Bit Score: 69.06  E-value: 3.09e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499628775  46 PDIILLDF-------LSLKAEQSEWE-IPediqldknplVMGLLPADDYED--IALKPGLDDFIRWPGSVNELKVRLaRL 115
Cdd:PRK10529  46 PDLIILDLglpdgdgIEFIRDLRQWSaIP----------VIVLSARSEESDkiAALDAGADDYLSKPFGIGELQARL-RV 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499628775 116 AEKWGMGEPG---IIKAGDLIIDTLGCEVTLAGQLLELTFREFELLKFLAQNRGRVFSREALLNKVWGYDYYGGDRTVDV 192
Cdd:PRK10529 115 ALRRHSATPApdpLVKFSDVTVDLAARVIHRGEEEVHLTPIEFRLLAVLLNNAGKVLTQRQLLNQVWGPNAVEHSHYLRI 194

                        170       180       190
                 ....*....|....*....|....*....|.
gi 499628775 193 HITRLRGKIEDS----THTFVETvrNIGYRF 219
Cdd:PRK10529 195 YMGHLRQKLEQDparpRHFITET--GIGYRF 223
PRK10336 PRK10336
two-component system response regulator QseB;
91-217 1.86e-12

two-component system response regulator QseB;


Pssm-ID: 182387 [Multi-domain]  Cd Length: 219  Bit Score: 64.15  E-value: 1.86e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499628775  91 LKPGLDDFIRWPGSVNELKVRLARLAEKWGMGEPGIIKAGDLIIDTLGCEVTLAGQLLELTFREFELLKFLAQNRGRVFS 170
Cdd:PRK10336  91 LRLGADDYLCKPFALIEVAARLEALMRRTNGQASNELRHGNVMLDPGKRIATLAGEPLTLKPKEFALLELLMRNAGRVLP 170

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 499628775 171 REALLNKVWGYDYYGGDRTVDVHITRLRGKIEDSthtFVETVRNIGY 217
Cdd:PRK10336 171 RKLIEEKLYTWDEEVTSNAVEVHVHHLRRKLGSD---FIRTVHGIGY 214
ompR PRK09468
osmolarity response regulator; Provisional
 72-219 6.66e-12

osmolarity response regulator; Provisional


Pssm-ID: 181883 [Multi-domain]  Cd Length: 239  Bit Score: 62.68  E-value: 6.66e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499628775  72 DKNPLVMGLLPADDYEDIA-LKPGLDDFIRWPGSVNELKVRLA-----RLAEKWGM--GEPGIIKAGDLIIDTLGCEVTL 143
Cdd:PRK09468  76 NPTPIIMLTAKGEEVDRIVgLEIGADDYLPKPFNPRELLARIRavlrrQAPELPGApsQEEEVIAFGKFKLNLGTRELFR 155

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 499628775 144 AGQLLELTFREFELLKFLAQNRGRVFSREALLNKVWGYDYYGGDRTVDVHITRLRGKIED--STHTFVETVRNIGYRF 219
Cdd:PRK09468 156 GDEPMPLTTGEFAVLKALVSHPREPLSRDKLMNLARGREYSAMERSIDVQISRLRRLIEEdpAHPRYIQTVWGLGYVF 233
PRK10643 PRK10643
two-component system response regulator PmrA;
91-218 2.32e-11

two-component system response regulator PmrA;


Pssm-ID: 182612 [Multi-domain]  Cd Length: 222  Bit Score: 60.82  E-value: 2.32e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499628775  91 LKPGLDDFIRWPGSVNELKVRL-ARLAEKWGMGEpGIIKAGDLIIDTLGCEVTLAGQLLELTFREFELLKFLAQNRGRVF 169
Cdd:PRK10643  91 LDVGADDYLVKPFALEELHARIrALIRRHQGQGE-NELQVGNLTLNLGRQQVWLDGQELILTPKEFALLSRLMLKAGSPV 169

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 499628775 170 SREALLNKVWGYDYYGGDRTVDVHITRLRGKIEDSThtfVETVRNIGYR 218
Cdd:PRK10643 170 HREILYQDIYNWDDEPSSNTLEVHIHNLRDKVGKDR---IRTVRGFGYM 215
PRK10766 PRK10766
two-component system response regulator TorR;
89-202 3.76e-11

two-component system response regulator TorR;


Pssm-ID: 182711 [Multi-domain]  Cd Length: 221  Bit Score: 60.44  E-value: 3.76e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499628775  89 IALKPGLDDFIRWPGSVNELKVR---------LARLAEKWGMGEPGIIKAGDLIIDTLGCEVTLAGQLLELTFREFELLK 159
Cdd:PRK10766  90 VGLEMGADDYVTKPLELRELLVRvknllwrisLARQAQPHAQEEDNCYRFAGYCLNVSRRTLERNGEPIKLTKAEYELLV 169

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 499628775 160 FLAQNRGRVFSREALLNKVWGYDYYGGDRTVDVHITRLRGKIE 202
Cdd:PRK10766 170 AFVTNPGQVLSRERLLRMLSHRVENPNDRTIDVLIRRLRHKLN 212
PRK15479 PRK15479
transcriptional regulator TctD;
91-221 2.41e-09

transcriptional regulator TctD;


Pssm-ID: 185376 [Multi-domain]  Cd Length: 221  Bit Score: 55.50  E-value: 2.41e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499628775  91 LKPGLDDFIRWPGSVNELKVRLARLAEKwGMGEP-GIIKAGDLIIDTLGcEVTLAGQLLELTFREFELLKFLAQNRGRVF 169
Cdd:PRK15479  91 LNVGADDYLPKPFELEELDARLRALLRR-SAGQVqEVQQLGELIFHDEG-YFLLQGQPLALTPREQALLTVLMYRRTRPV 168

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 499628775 170 SREALLNKVWGYDYYGGDRTVDVHITRLRGKIEDSTHTFVeTVRNIGYRFKR 221
Cdd:PRK15479 169 SRQQLFEQVFSLNDEVSPESIELYIHRLRKKLQGSDVRIT-TLRGLGYVLER 219
PRK10816 PRK10816
two-component system response regulator PhoP;
41-219 6.58e-09

two-component system response regulator PhoP;


Pssm-ID: 182755 [Multi-domain]  Cd Length: 223  Bit Score: 53.97  E-value: 6.58e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499628775  41 LFEFAPDIILLDfLSLKAEQSEWEIPEDIQLDKNPLVMGLLPADDYED--IALKPGLDDFIRWPGSVNELKVRLARLAEK 118
Cdd:PRK10816  40 LNEHLPDIAIVD-LGLPDEDGLSLIRRWRSNDVSLPILVLTARESWQDkvEVLSAGADDYVTKPFHIEEVMARMQALMRR 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499628775 119 WGMGEPGIIKAGDLIIDTLGCEVTLAGQLLELTFREFELLKFLAQNRGRVFSREALLNKVWGYDYYGGDRTVDVHITRLR 198
Cdd:PRK10816 119 NSGLASQVISLPPFQVDLSRRELSINDEVIKLTAFEYTIMETLIRNNGKVVSKDSLMLQLYPDAELRESHTIDVLMGRLR 198

                        170       180
                 ....*....|....*....|..
gi 499628775 199 GKIEDS-THTFVETVRNIGYRF 219
Cdd:PRK10816 199 KKIQAQyPQEVITTVRGQGYRF 220
PRK11173 PRK11173
two-component response regulator; Provisional
 141-219 1.24e-08

two-component response regulator; Provisional


Pssm-ID: 183013 [Multi-domain]  Cd Length: 237  Bit Score: 53.48  E-value: 1.24e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499628775 141 VTLAGQLLELTFREFELLKFLAQNRGRVFSREALLNKVWGYDYYGGDRTVDVHITRLRGKIEDSTHT--FVETVRNIGYR 218
Cdd:PRK11173 152 ISPDGEQYKLPRSEFRAMLHFCENPGKIQSRAELLKKMTGRELKPHDRTVDVTIRRIRKHFESTPDTpeIIATIHGEGYR 231


                 .
gi 499628775 219 F 219
Cdd:PRK11173 232 F 232
PRK12370 PRK12370
HilA/EilA family virulence transcriptional regulator;
153-221 4.57e-05

HilA/EilA family virulence transcriptional regulator;


Pssm-ID: 237080 [Multi-domain]  Cd Length: 553  Bit Score: 43.69  E-value: 4.57e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 499628775 153 REFELLKFLAQNRGRVFSREALLNKVWGyDYYGGDRTVDVHITRLRgKI--EDSTHTFVETVRNIGYRFKR 221
Cdd:PRK12370  39 KEYAVLVILLEAAGEIVSKNTLLDQVWG-DAEVNEESLTRCIYALR-RIlsEDKEHRYIETLYGQGYRFNR 107
PRK13856 PRK13856
two-component response regulator VirG; Provisional
 144-219 7.09e-05

two-component response regulator VirG; Provisional


Pssm-ID: 172377 [Multi-domain]  Cd Length: 241  Bit Score: 42.49  E-value: 7.09e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499628775 144 AGQLLELTFREFELL-KFLAQNRgRVFSREALL--NKVWGYDYYggDRTVDVHITRLRGKIED--STHTFVETVRNIGYR 218
Cdd:PRK13856 150 AGGEVKLTAGEFNLLvAFLEKPR-DVLSREQLLiaSRVREEEVY--DRSIDVLILRLRRKLEQdpANPQLIKTARGAGYF 226


                 .
gi 499628775 219 F 219
Cdd:PRK13856 227 F 227
PRK07239 PRK07239
bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated
 127-218 9.43e-05

bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated


Pssm-ID: 235981 [Multi-domain]  Cd Length: 381  Bit Score: 42.66  E-value: 9.43e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499628775 127 IKAGDLIIDTLGCEVTLAGQLLELTFREFELLKFLAQNRGRVFSREALLNKVWGydyYGGD-RTVDVHITRLRGKIEDst 205
Cdd:PRK07239 284 LRAAGHVLEIRGHAVVVDGEVKPLSPAPMALLRALAARPGRVVSREDLLAALPG---GGTDeHAVETAVARLRTALGD-- 358

                         90
                 ....*....|...
gi 499628775 206 HTFVETVRNIGYR 218
Cdd:PRK07239 359 PKLVQTVVKRGYR 371
PRK10153 PRK10153
DNA-binding transcriptional activator CadC; Provisional
 153-179 2.73e-03

DNA-binding transcriptional activator CadC; Provisional


Pssm-ID: 236658 [Multi-domain]  Cd Length: 517  Bit Score: 38.10  E-value: 2.73e-03
                         10        20
                 ....*....|....*....|....*..
gi 499628775 153 REFELLKFLAQNRGRVFSREALLNKVW 179
Cdd:PRK10153  32 RLIDLLVFFAQHSGEVLSRDELIDHVW 58
REC_OmpR_YycF-like cd17614
phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF ...
 6-112 3.88e-03

phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF appears to play an important role in cell wall integrity in a wide range of gram-positive bacteria, and may also modulate cell membrane integrity. It functions as part of a phosphotransfer system that ultimately controls the levels of competence within the bacteria. YycF belongs to the OmpR family of response regulators, which are characterized by a REC domain and a winged helix-turn-helix effector domain involved in DNA binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381130 [Multi-domain]  Cd Length: 115  Bit Score: 35.86  E-value: 3.88e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499628775   6 IVTADAKKNGNLLK-ELEADRFEIKQAVSCVLAYPSLFEFAPDIILLDFlsLKAEQSEWEIPEDIQLDKN-PLVMglLPA 83
Cdd:cd17614    2 LVVDDEKPISDILKfNLTKEGYEVVTAYDGREALEKVEEEQPDLILLDL--MLPEKDGLEVCREVRKTSNvPIIM--LTA 77

                         90       100       110
                 ....*....|....*....|....*....|..
gi 499628775  84 DDYE---DIALKPGLDDFIRWPGSVNELKVRL 112
Cdd:cd17614   78 KDSEvdkVLGLELGADDYVTKPFSNRELLARV 109
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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