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Conserved domains on  [gi|499629185|ref|WP_011309919|]
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MULTISPECIES: winged helix-turn-helix domain-containing protein [Dehalococcoides]

Protein Classification

response regulator transcription factor KdpE( domain architecture ID 1002769)

two-component system response regulator transcription factor KdpE binds DNA upon phosphorylation and is a member of the two-component regulatory system KdpD/KdpE involved in the regulation of the kdp operon

CATH:  1.10.10.10
Gene Ontology:  GO:0000156|GO:0000976|GO:0003677|GO:0006355
PubMed:  1449064|1970651

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK10529 super family cl32528
DNA-binding transcriptional activator KdpE; Provisional
 40-227 2.47e-37

DNA-binding transcriptional activator KdpE; Provisional


The actual alignment was detected with superfamily member PRK10529:

Pssm-ID: 182522 [Multi-domain]  Cd Length: 225  Bit Score: 129.92  E-value: 2.47e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499629185  40 GLIE--TLSPDLIILDSYLLDSTTQNIIISIREFSDIPIIILNTIGEIGSKVQFLEDGADECIEKPINGIECQAVTNALL 117
Cdd:PRK10529  37 GLLEaaTRKPDLIILDLGLPDGDGIEFIRDLRQWSAIPVIVLSARSEESDKIAALDAGADDYLSKPFGIGELQARLRVAL 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499629185 118 RRNMnlGFKAESTIPISNGLEVNFNRRELTQSGIPVHLTPIEFSLLALLARNSGQVLTYRMLLEKVWGTEYSGDLNLLKK 197
Cdd:PRK10529 117 RRHS--ATPAPDPLVKFSDVTVDLAARVIHRGEEEVHLTPIEFRLLAVLLNNAGKVLTQRQLLNQVWGPNAVEHSHYLRI 194

                        170       180       190
                 ....*....|....*....|....*....|
gi 499629185 198 HIHNLRAKIEVNPEYPKIIVTERGLGYSLI 227
Cdd:PRK10529 195 YMGHLRQKLEQDPARPRHFITETGIGYRFM 224
 
Name Accession Description Interval E-value
PRK10529 PRK10529
DNA-binding transcriptional activator KdpE; Provisional
 40-227 2.47e-37

DNA-binding transcriptional activator KdpE; Provisional


Pssm-ID: 182522 [Multi-domain]  Cd Length: 225  Bit Score: 129.92  E-value: 2.47e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499629185  40 GLIE--TLSPDLIILDSYLLDSTTQNIIISIREFSDIPIIILNTIGEIGSKVQFLEDGADECIEKPINGIECQAVTNALL 117
Cdd:PRK10529  37 GLLEaaTRKPDLIILDLGLPDGDGIEFIRDLRQWSAIPVIVLSARSEESDKIAALDAGADDYLSKPFGIGELQARLRVAL 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499629185 118 RRNMnlGFKAESTIPISNGLEVNFNRRELTQSGIPVHLTPIEFSLLALLARNSGQVLTYRMLLEKVWGTEYSGDLNLLKK 197
Cdd:PRK10529 117 RRHS--ATPAPDPLVKFSDVTVDLAARVIHRGEEEVHLTPIEFRLLAVLLNNAGKVLTQRQLLNQVWGPNAVEHSHYLRI 194

                        170       180       190
                 ....*....|....*....|....*....|
gi 499629185 198 HIHNLRAKIEVNPEYPKIIVTERGLGYSLI 227
Cdd:PRK10529 195 YMGHLRQKLEQDPARPRHFITETGIGYRFM 224
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
 1-218 8.40e-35

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 122.76  E-value: 8.40e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499629185   1 MKILIMCGDPQVLKDLVLCLkiryQNLEYTVS--DNITEGTGLIETLSPDLIILDSYLLDSTTQNIIISIREF-SDIPII 77
Cdd:COG0745    2 PRILVVEDDPDIRELLADAL----EREGYEVDtaADGEEALELLEEERPDLILLDLMLPGMDGLEVCRRLRARpSDIPII 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499629185  78 ILNTIGEIGSKVQFLEDGADECIEKPINGIECQAVTNALLRRNmnlgfkaeSTIPISNGLEVNFNRRELTQSGIPVHLTP 157
Cdd:COG0745   78 MLTARDDEEDRVRGLEAGADDYLTKPFDPEELLARIRALLRRR--------AAEVLRVGDLLDLAAREVTRDGEPVELTP 149

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 499629185 158 IEFSLLALLARNSGQVLTYRMLLEKVWGTEYsGDLNLLKKHIHNLRAKIEvnpeyPKIIVT 218
Cdd:COG0745  150 KEFRLLELLMRNPGRVVSREQLLEEVWGYDY-GDDRTVDVHISRLRKKLE-----DDLIET 204
trans_reg_C cd00383
DNA-binding effector domain of two-component system response regulators; Bacteria and some ...
 137-226 1.12e-29

DNA-binding effector domain of two-component system response regulators; Bacteria and some eukaryotes use two-component signal transduction systems to detect and respond to changes in the environment. The systems consists of a sensor histidine kinase and a response regulator. The former autophosphorylates a histidine residue on detecting an external stimulus. The phosphate is then transferred to an invariant aspartate residue in a highly conserved receiver domain of the response regulator. Phosphorylation activates a variable effector domain of the response regulator, which triggers the cellular response. This C-terminal effector domain belongs to the winged helix-turn-helix family of transcriptional regulators and contains DNA and RNA polymerase binding sites. Several dimers or monomers bind head to tail to small tandem repeats upstream of the genes. The RNA polymerase binding sites interact with the alpha or sigma subunit of RNA polymerase.


Pssm-ID: 294013 [Multi-domain]  Cd Length: 89  Bit Score: 106.02  E-value: 1.12e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499629185 137 LEVNFNRRELTQSGIPVHLTPIEFSLLALLARNSGQVLTYRMLLEKVWGTEYSGDLNLLKKHIHNLRAKIEVNPEyPKII 216
Cdd:cd00383    1 LRLDPARREVTVDGEEVELTPKEFELLELLARNPGRVVSREELLEAVWGYDYEVDDRTVDVHISRLRKKLEDDPE-PRLI 79

                         90
                 ....*....|
gi 499629185 217 VTERGLGYSL 226
Cdd:cd00383   80 KTVRGVGYRL 89
Trans_reg_C pfam00486
Transcriptional regulatory protein, C terminal;
150-226 2.71e-26

Transcriptional regulatory protein, C terminal;


Pssm-ID: 425712 [Multi-domain]  Cd Length: 77  Bit Score: 96.81  E-value: 2.71e-26
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 499629185  150 GIPVHLTPIEFSLLALLARNSGQVLTYRMLLEKVWGTEYSGDLNLLKKHIHNLRAKIEVNPEYPKIIVTERGLGYSL 226
Cdd:pfam00486   1 GEEVELTPKEFKLLELLAENPGRVVSREQLLEEVWGEDYDVDDNTVDVHISRLRKKLEDDPRDPRLIKTVRGVGYRL 77
Trans_reg_C smart00862
Transcriptional regulatory protein, C terminal; This domain is almost always found associated ...
 150-226 5.68e-26

Transcriptional regulatory protein, C terminal; This domain is almost always found associated with the response regulator receiver domain. It may play a role in DNA binding.


Pssm-ID: 214866 [Multi-domain]  Cd Length: 76  Bit Score: 96.08  E-value: 5.68e-26
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 499629185   150 GIPVHLTPIEFSLLALLARNSGQVLTYRMLLEKVWGTEYSGDLNLLKKHIHNLRAKIEvNPEYPKIIVTERGLGYSL 226
Cdd:smart00862   1 GEPIKLTPKEFRLLELLLRNPGRVVSREELLEAVWGDDEDVDDNTLDVHISRLRKKLE-DDGDPRLIETVRGVGYRL 76
 
Name Accession Description Interval E-value
PRK10529 PRK10529
DNA-binding transcriptional activator KdpE; Provisional
 40-227 2.47e-37

DNA-binding transcriptional activator KdpE; Provisional


Pssm-ID: 182522 [Multi-domain]  Cd Length: 225  Bit Score: 129.92  E-value: 2.47e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499629185  40 GLIE--TLSPDLIILDSYLLDSTTQNIIISIREFSDIPIIILNTIGEIGSKVQFLEDGADECIEKPINGIECQAVTNALL 117
Cdd:PRK10529  37 GLLEaaTRKPDLIILDLGLPDGDGIEFIRDLRQWSAIPVIVLSARSEESDKIAALDAGADDYLSKPFGIGELQARLRVAL 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499629185 118 RRNMnlGFKAESTIPISNGLEVNFNRRELTQSGIPVHLTPIEFSLLALLARNSGQVLTYRMLLEKVWGTEYSGDLNLLKK 197
Cdd:PRK10529 117 RRHS--ATPAPDPLVKFSDVTVDLAARVIHRGEEEVHLTPIEFRLLAVLLNNAGKVLTQRQLLNQVWGPNAVEHSHYLRI 194

                        170       180       190
                 ....*....|....*....|....*....|
gi 499629185 198 HIHNLRAKIEVNPEYPKIIVTERGLGYSLI 227
Cdd:PRK10529 195 YMGHLRQKLEQDPARPRHFITETGIGYRFM 224
orf27 CHL00148
Ycf27; Reviewed
 1-224 7.86e-36

Ycf27; Reviewed


Pssm-ID: 214376 [Multi-domain]  Cd Length: 240  Bit Score: 126.75  E-value: 7.86e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499629185   1 MKILIMCGDPQVLKDLVLCLKIRYQNLeYTVSDNItEGTGLIETLSPDLIILDSYLLDSTTQNIIISIREFSDIPIIILN 80
Cdd:CHL00148   7 EKILVVDDEAYIRKILETRLSIIGYEV-ITASDGE-EALKLFRKEQPDLVILDVMMPKLDGYGVCQEIRKESDVPIIMLT 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499629185  81 TIGEIGSKVQFLEDGADECIEKPINGIECQAVTNALLRR----NMNLGFKAESTIPISNgLEVNFNRRELTQSGIPVHLT 156
Cdd:CHL00148  85 ALGDVSDRITGLELGADDYVVKPFSPKELEARIRSVLRRtnkkSFSSKIPNSSIIRIGF-LKIDLNKKQVYKNNERIRLT 163

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499629185 157 PIEFSLLALLARNSGQVLTYRMLLEKVWGTEYSG--DLNLLKKHIHNLRAKIEVNPEYPKIIVTERGLGY 224
Cdd:CHL00148 164 GMEFSLLELLISKSGEIFSRATILKEVWGYTPERhiDTRVVDVHISRLRAKLEDDPSNPDLILTARGTGY 233
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
 1-218 8.40e-35

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 122.76  E-value: 8.40e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499629185   1 MKILIMCGDPQVLKDLVLCLkiryQNLEYTVS--DNITEGTGLIETLSPDLIILDSYLLDSTTQNIIISIREF-SDIPII 77
Cdd:COG0745    2 PRILVVEDDPDIRELLADAL----EREGYEVDtaADGEEALELLEEERPDLILLDLMLPGMDGLEVCRRLRARpSDIPII 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499629185  78 ILNTIGEIGSKVQFLEDGADECIEKPINGIECQAVTNALLRRNmnlgfkaeSTIPISNGLEVNFNRRELTQSGIPVHLTP 157
Cdd:COG0745   78 MLTARDDEEDRVRGLEAGADDYLTKPFDPEELLARIRALLRRR--------AAEVLRVGDLLDLAAREVTRDGEPVELTP 149

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 499629185 158 IEFSLLALLARNSGQVLTYRMLLEKVWGTEYsGDLNLLKKHIHNLRAKIEvnpeyPKIIVT 218
Cdd:COG0745  150 KEFRLLELLMRNPGRVVSREQLLEEVWGYDY-GDDRTVDVHISRLRKKLE-----DDLIET 204
trans_reg_C cd00383
DNA-binding effector domain of two-component system response regulators; Bacteria and some ...
 137-226 1.12e-29

DNA-binding effector domain of two-component system response regulators; Bacteria and some eukaryotes use two-component signal transduction systems to detect and respond to changes in the environment. The systems consists of a sensor histidine kinase and a response regulator. The former autophosphorylates a histidine residue on detecting an external stimulus. The phosphate is then transferred to an invariant aspartate residue in a highly conserved receiver domain of the response regulator. Phosphorylation activates a variable effector domain of the response regulator, which triggers the cellular response. This C-terminal effector domain belongs to the winged helix-turn-helix family of transcriptional regulators and contains DNA and RNA polymerase binding sites. Several dimers or monomers bind head to tail to small tandem repeats upstream of the genes. The RNA polymerase binding sites interact with the alpha or sigma subunit of RNA polymerase.


Pssm-ID: 294013 [Multi-domain]  Cd Length: 89  Bit Score: 106.02  E-value: 1.12e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499629185 137 LEVNFNRRELTQSGIPVHLTPIEFSLLALLARNSGQVLTYRMLLEKVWGTEYSGDLNLLKKHIHNLRAKIEVNPEyPKII 216
Cdd:cd00383    1 LRLDPARREVTVDGEEVELTPKEFELLELLARNPGRVVSREELLEAVWGYDYEVDDRTVDVHISRLRKKLEDDPE-PRLI 79

                         90
                 ....*....|
gi 499629185 217 VTERGLGYSL 226
Cdd:cd00383   80 KTVRGVGYRL 89
PRK09836 PRK09836
DNA-binding transcriptional activator CusR; Provisional
 1-226 2.55e-27

DNA-binding transcriptional activator CusR; Provisional


Pssm-ID: 182102 [Multi-domain]  Cd Length: 227  Bit Score: 104.24  E-value: 2.55e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499629185   1 MKILIMcgDPQVLKDLVLCLKIRYQNLEYTVSDNITEGTGLIETLSPDLIILDSYLLDSTTQNIIISIREFSD-IPIIIL 79
Cdd:PRK09836   1 MKLLIV--EDEKKTGEYLTKGLTEAGFVVDLADNGLNGYHLAMTGDYDLIILDIMLPDVNGWDIVRMLRSANKgMPILLL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499629185  80 NTIGEIGSKVQFLEDGADECIEKPINGIECQAVTNALLRRNMNLgfKAESTIPISNgLEVNFNRRELTQSGIPVHLTPIE 159
Cdd:PRK09836  79 TALGTIEHRVKGLELGADDYLVKPFAFAELLARVRTLLRRGAAV--IIESQFQVAD-LMVDLVSRKVTRSGTRITLTSKE 155

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 499629185 160 FSLLALLARNSGQVLTYRMLLEKVWGTEYSGDLNLLKKHIHNLRAKIEVNPEyPKIIVTERGLGYSL 226
Cdd:PRK09836 156 FTLLEFFLRHQGEVLPRSLIASQVWDMNFDSDTNAIDVAVKRLRGKIDNDFE-PKLIQTVRGVGYML 221
Trans_reg_C pfam00486
Transcriptional regulatory protein, C terminal;
150-226 2.71e-26

Transcriptional regulatory protein, C terminal;


Pssm-ID: 425712 [Multi-domain]  Cd Length: 77  Bit Score: 96.81  E-value: 2.71e-26
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 499629185  150 GIPVHLTPIEFSLLALLARNSGQVLTYRMLLEKVWGTEYSGDLNLLKKHIHNLRAKIEVNPEYPKIIVTERGLGYSL 226
Cdd:pfam00486   1 GEEVELTPKEFKLLELLAENPGRVVSREQLLEEVWGEDYDVDDNTVDVHISRLRKKLEDDPRDPRLIKTVRGVGYRL 77
Trans_reg_C smart00862
Transcriptional regulatory protein, C terminal; This domain is almost always found associated ...
 150-226 5.68e-26

Transcriptional regulatory protein, C terminal; This domain is almost always found associated with the response regulator receiver domain. It may play a role in DNA binding.


Pssm-ID: 214866 [Multi-domain]  Cd Length: 76  Bit Score: 96.08  E-value: 5.68e-26
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 499629185   150 GIPVHLTPIEFSLLALLARNSGQVLTYRMLLEKVWGTEYSGDLNLLKKHIHNLRAKIEvNPEYPKIIVTERGLGYSL 226
Cdd:smart00862   1 GEPIKLTPKEFRLLELLLRNPGRVVSREELLEAVWGDDEDVDDNTLDVHISRLRKKLE-DDGDPRLIETVRGVGYRL 76
PRK10643 PRK10643
two-component system response regulator PmrA;
1-226 9.66e-23

two-component system response regulator PmrA;


Pssm-ID: 182612 [Multi-domain]  Cd Length: 222  Bit Score: 92.02  E-value: 9.66e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499629185   1 MKILIMCGDPQVLKDLVLCLkiryQNLEYTV--SDNITEGTGLIETLSPDLIILDSYLLDSTTQNIIISIR-EFSDIPII 77
Cdd:PRK10643   1 MKILIVEDDTLLLQGLILAL----QTEGYACdcASTAREAEALLESGHYSLVVLDLGLPDEDGLHLLRRWRqKKYTLPVL 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499629185  78 ILNTIGEIGSKVQFLEDGADECIEKPINGIECQAVTNALLRRNMNLGfkaESTIPISNgLEVNFNRRELTQSGIPVHLTP 157
Cdd:PRK10643  77 ILTARDTLEDRVAGLDVGADDYLVKPFALEELHARIRALIRRHQGQG---ENELQVGN-LTLNLGRQQVWLDGQELILTP 152

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 499629185 158 IEFSLLALLARNSGQVLtYRMLLEK---VWGTEYSGdlNLLKKHIHNLRAKIEVNPeypkiIVTERGLGYSL 226
Cdd:PRK10643 153 KEFALLSRLMLKAGSPV-HREILYQdiyNWDDEPSS--NTLEVHIHNLRDKVGKDR-----IRTVRGFGYML 216
PRK11517 PRK11517
DNA-binding response regulator HprR;
31-226 1.01e-21

DNA-binding response regulator HprR;


Pssm-ID: 183172 [Multi-domain]  Cd Length: 223  Bit Score: 89.19  E-value: 1.01e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499629185  31 VSDNITEGT-GLIETLSPD--LIILDSYLLDSTTQNIIISIREFSDIPIIILNTIGEIGSKVQFLEDGADECIEKPINGI 107
Cdd:PRK11517  26 VIDAVSDGRdGLYLALKDDyaLIILDIMLPGMDGWQILQTLRTAKQTPVICLTARDSVDDRVRGLDSGANDYLVKPFSFS 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499629185 108 ECQAVTNALLRRNMNLgfkaESTIPISnGLEVNFNRRELTQSGIPVHLTPIEFSLLALLARNSGQVLTYRMLLEKVWGTE 187
Cdd:PRK11517 106 ELLARVRAQLRQHHAL----NSTLEIS-GLRMDSVSQSVSRDNISITLTRKEFQLLWLLASRAGEIIPRTVIASEIWGIN 180

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 499629185 188 YSGDLNLLKKHIHNLRAKIEvNPEYPKIIVTERGLGYSL 226
Cdd:PRK11517 181 FDSDTNTVDVAIRRLRAKVD-DPFPEKLIATIRGMGYSF 218
PRK11083 PRK11083
DNA-binding response regulator CreB; Provisional
 47-226 4.78e-21

DNA-binding response regulator CreB; Provisional


Pssm-ID: 236838 [Multi-domain]  Cd Length: 228  Bit Score: 87.71  E-value: 4.78e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499629185  47 PDLIILDSYLLDSTTQNIIISIREF-SDIPIIILNTIGEIGSKVQFLEDGADECIEKPINGIECQAVTNALLRRnMNlGF 125
Cdd:PRK11083  48 PDLVILDVGLPDISGFELCRQLLAFhPALPVIFLTARSDEVDRLVGLEIGADDYVAKPFSPREVAARVRTILRR-VK-KF 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499629185 126 KAESTIPISNGLEVNFNRRELTQSGIPVHLTPIEFSLLALLARNSGQVLTYRMLLEKVWG-TEYSGDLNlLKKHIHNLRA 204
Cdd:PRK11083 126 AAPSPVIRIGHFELDEPAARISYFGTPLTLTRYEFLLLKTLLLSPGRVFSRQQLMDIVWEdAQDSYDRT-VDTHIKTLRA 204

                        170       180
                 ....*....|....*....|...
gi 499629185 205 KI-EVNPEYPKiIVTERGLGYSL 226
Cdd:PRK11083 205 KLrAINPDLSP-INTHRGMGYSL 226
ompR PRK09468
osmolarity response regulator; Provisional
 2-224 3.55e-20

osmolarity response regulator; Provisional


Pssm-ID: 181883 [Multi-domain]  Cd Length: 239  Bit Score: 85.41  E-value: 3.55e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499629185   2 KILIMCGDPQvLKDLVLclkiRY---QNLEYTVSDNITEGTGLIETLSPDLIILDSYLLDSTTQNIIISIREFSD-IPII 77
Cdd:PRK09468   7 KILVVDDDMR-LRALLE----RYlteQGFQVRSAANAEQMDRLLTRESFHLMVLDLMLPGEDGLSICRRLRSQNNpTPII 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499629185  78 ILNTIGEIGSKVQFLEDGADECIEKPINGIECQAVTNALLRRNMN--LGFKAESTIPISNG-LEVNFNRRELTQSGIPVH 154
Cdd:PRK09468  82 MLTAKGEEVDRIVGLEIGADDYLPKPFNPRELLARIRAVLRRQAPelPGAPSQEEEVIAFGkFKLNLGTRELFRGDEPMP 161

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499629185 155 LTPIEFSLLALLARNSGQVLTYRMLLEKVWGTEYSGDLNLLKKHIHNLRAKIEVNPEYPKIIVTERGLGY 224
Cdd:PRK09468 162 LTTGEFAVLKALVSHPREPLSRDKLMNLARGREYSAMERSIDVQISRLRRLIEEDPAHPRYIQTVWGLGY 231
CadC1 COG3710
DNA-binding winged helix-turn-helix (wHTH) domain [Transcription];
135-227 5.12e-20

DNA-binding winged helix-turn-helix (wHTH) domain [Transcription];


Pssm-ID: 442924 [Multi-domain]  Cd Length: 106  Bit Score: 81.49  E-value: 5.12e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499629185 135 NGLEVNFNRRELTQSGIPVHLTPIEFSLLALLARNSGQVLTYRMLLEKVWGTEYSGDlNLLKKHIHNLRAKIEVNPEYPK 214
Cdd:COG3710    6 GDFRLDPARRELLRDGEPVRLSPRAFDLLLLLLEHPGRVVSRDELLAAVWPGRVVSD-NSLTQAISRLRKALGDDGLEPR 84

                         90
                 ....*....|...
gi 499629185 215 IIVTERGLGYSLI 227
Cdd:COG3710   85 LIRTVPRRGYRLV 97
PRK10955 PRK10955
envelope stress response regulator transcription factor CpxR;
46-227 2.11e-17

envelope stress response regulator transcription factor CpxR;


Pssm-ID: 182864 [Multi-domain]  Cd Length: 232  Bit Score: 77.92  E-value: 2.11e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499629185  46 SPDLIILDSYLLDSTTQNIIISIREFSDIPIIILNTIGEIGSKVQFLEDGADECIEKPINGIECQAVTNALLRRN----- 120
Cdd:PRK10955  44 SIDLLLLDVMMPKKNGIDTLKELRQTHQTPVIMLTARGSELDRVLGLELGADDYLPKPFNDRELVARIRAILRRShwseq 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499629185 121 MNLGFKAESTIPIsNGLEVNFNRRELTQSGIPVHLTPIEFSLLALLARNSGQVLTYRMLLEKVWGTEYSGDLNLLKKHIH 200
Cdd:PRK10955 124 QQNNDNGSPTLEV-DALSLNPGRQEASFDGQTLELTGTEFTLLYLLAQHLGQVVSREHLSQEVLGKRLTPFDRAIDMHIS 202

                        170       180
                 ....*....|....*....|....*..
gi 499629185 201 NLRAKIEVNPEYPKIIVTERGLGYSLI 227
Cdd:PRK10955 203 NLRRKLPDRKDGHPWFKTLRGRGYLMV 229
PRK10161 PRK10161
phosphate response regulator transcription factor PhoB;
47-230 2.86e-17

phosphate response regulator transcription factor PhoB;


Pssm-ID: 182277 [Multi-domain]  Cd Length: 229  Bit Score: 77.45  E-value: 2.86e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499629185  47 PDLIILDSYLLDSTTQNIIISIREFS---DIPIIILNTIGEIGSKVQFLEDGADECIEKPINGIECQAVTNALLRRNMNL 123
Cdd:PRK10161  47 PDLILLDWMLPGGSGIQFIKHLKRESmtrDIPVVMLTARGEEEDRVRGLETGADDYITKPFSPKELVARIKAVMRRISPM 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499629185 124 GfkAESTIPIsNGLEVNFNRRELTQSGIPVHLTPIEFSLLALLARNSGQVLTYRMLLEKVWGTEYSGDLNLLKKHIHNLR 203
Cdd:PRK10161 127 A--VEEVIEM-QGLSLDPTSHRVMAGEEPLEMGPTEFKLLHFFMTHPERVYSREQLLNHVWGTNVYVEDRTVDVHIRRLR 203

                        170       180
                 ....*....|....*....|....*..
gi 499629185 204 AKIEvNPEYPKIIVTERGLGYSLIRQF 230
Cdd:PRK10161 204 KALE-PGGHDRMVQTVRGTGYRFSTRF 229
PRK10336 PRK10336
two-component system response regulator QseB;
48-226 1.98e-16

two-component system response regulator QseB;


Pssm-ID: 182387 [Multi-domain]  Cd Length: 219  Bit Score: 74.93  E-value: 1.98e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499629185  48 DLIILDSYLLDSTTQNIIISIREFSDI-PIIILNTIGEIGSKVQFLEDGADECIEKPINGIECQAVTNALLRRNmnlgfK 126
Cdd:PRK10336  46 DAVILDLTLPGMDGRDILREWREKGQRePVLILTARDALAERVEGLRLGADDYLCKPFALIEVAARLEALMRRT-----N 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499629185 127 AESTIPISNG-LEVNFNRRELTQSGIPVHLTPIEFSLLALLARNSGQVLTYRMLLEKV--WGTEYSGdlNLLKKHIHNLR 203
Cdd:PRK10336 121 GQASNELRHGnVMLDPGKRIATLAGEPLTLKPKEFALLELLMRNAGRVLPRKLIEEKLytWDEEVTS--NAVEVHVHHLR 198

                        170       180
                 ....*....|....*....|...
gi 499629185 204 AKIEvnpeyPKIIVTERGLGYSL 226
Cdd:PRK10336 199 RKLG-----SDFIRTVHGIGYTL 216
PRK10816 PRK10816
two-component system response regulator PhoP;
46-224 7.56e-16

two-component system response regulator PhoP;


Pssm-ID: 182755 [Multi-domain]  Cd Length: 223  Bit Score: 73.62  E-value: 7.56e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499629185  46 SPDLIILDSYLLDSTTQNIIISIREFS-DIPIIILNTIGEIGSKVQFLEDGADECIEKPINGIECQAVTNALLRRNMNLG 124
Cdd:PRK10816  44 LPDIAIVDLGLPDEDGLSLIRRWRSNDvSLPILVLTARESWQDKVEVLSAGADDYVTKPFHIEEVMARMQALMRRNSGLA 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499629185 125 FKAESTIPisngLEVNFNRRELTQSGIPVHLTPIEFSLLALLARNSGQVLTYRMLLEKVWgteysGDLNLLKKH-----I 199
Cdd:PRK10816 124 SQVISLPP----FQVDLSRRELSINDEVIKLTAFEYTIMETLIRNNGKVVSKDSLMLQLY-----PDAELRESHtidvlM 194

                        170       180
                 ....*....|....*....|....*.
gi 499629185 200 HNLRAKIEVnpEYP-KIIVTERGLGY 224
Cdd:PRK10816 195 GRLRKKIQA--QYPqEVITTVRGQGY 218
PRK10710 PRK10710
DNA-binding transcriptional regulator BaeR; Provisional
 46-224 6.97e-15

DNA-binding transcriptional regulator BaeR; Provisional


Pssm-ID: 182665 [Multi-domain]  Cd Length: 240  Bit Score: 71.25  E-value: 6.97e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499629185  46 SPDLIILDSYLLDSTTQNIIISIREFSDIPIIILNT-IGEIgSKVQFLEDGADECIEKPINGIECQAVTNALLRRnmnLG 124
Cdd:PRK10710  54 PPDLILLDLMLPGTDGLTLCREIRRFSDIPIVMVTAkIEEI-DRLLGLEIGADDYICKPYSPREVVARVKTILRR---CK 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499629185 125 FKAESTIPISNG-LEVNFNRRELTQSGIPVHLTPIEFSLLALLARNSGQVLTYRMLLEKVWG-----TEYSGDlnllkKH 198
Cdd:PRK10710 130 PQRELQQQDAESpLIIDESRFQASWRGKMLDLTPAEFRLLKTLSHEPGKVFSREQLLNHLYDdyrvvTDRTID-----SH 204

                        170       180
                 ....*....|....*....|....*.
gi 499629185 199 IHNLRAKIEVNPEYPKIIVTERGLGY 224
Cdd:PRK10710 205 IKNLRRKLESLDAEQSFIRAVYGVGY 230
PRK13856 PRK13856
two-component response regulator VirG; Provisional
 48-224 2.99e-13

two-component response regulator VirG; Provisional


Pssm-ID: 172377 [Multi-domain]  Cd Length: 241  Bit Score: 66.76  E-value: 2.99e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499629185  48 DLIILDSYLLDSTTQNIIISIREFSDIPIIILNTIG-EIGSKVQFLEDGADECIEKPINGIECQAVTNALLRRNMNLGFK 126
Cdd:PRK13856  47 DVVVVDLNLGREDGLEIVRSLATKSDVPIIIISGDRlEEADKVVALELGATDFIAKPFGTREFLARIRVALRVRPNVVRT 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499629185 127 AESTIPISNGLEVNFNRRELT-QSGIPVHLTPIEFSLLALLARNSGQVLTYRMLL--EKVWGTE-YSGDLNLLkkhIHNL 202
Cdd:PRK13856 127 KDRRSFCFADWTLNLRQRRLIsEAGGEVKLTAGEFNLLVAFLEKPRDVLSREQLLiaSRVREEEvYDRSIDVL---ILRL 203

                        170       180
                 ....*....|....*....|..
gi 499629185 203 RAKIEVNPEYPKIIVTERGLGY 224
Cdd:PRK13856 204 RRKLEQDPANPQLIKTARGAGY 225
REC_OmpR_KdpE-like cd17620
phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a ...
 3-103 1.68e-12

phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a component of the KdpD/KdpE two-component system (TCS) and is activated when histidine kinase KdpD senses a drop in external K+ concentration or upshift in ionic osmolarity, resulting in the expression of a heterooligomeric transporter KdpFABC. In addition, the KdpD/KdpE TCS is also an adaptive regulator involved in the virulence and intracellular survival of pathogenic bacteria. KdpE is a member of the OmpR family of DNA-binding response regulators that contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381135 [Multi-domain]  Cd Length: 99  Bit Score: 61.41  E-value: 1.68e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499629185   3 ILIMCGDPQVLKDLVLCLKIryQNLEYTVSDNITEGTGLIETLSPDLIILDSYLLDSTTQNIIISIREFSDIPIIILNTI 82
Cdd:cd17620    1 ILVIEDEPQIRRFLRTALEA--HGYRVFEAETGQEGLLEAATRKPDLIILDLGLPDMDGLEVIRRLREWSAVPVIVLSAR 78

                         90       100
                 ....*....|....*....|.
gi 499629185  83 GEIGSKVQFLEDGADECIEKP 103
Cdd:cd17620   79 DEESDKIAALDAGADDYLTKP 99
PRK11173 PRK11173
two-component response regulator; Provisional
 68-224 2.23e-12

two-component response regulator; Provisional


Pssm-ID: 183013 [Multi-domain]  Cd Length: 237  Bit Score: 64.27  E-value: 2.23e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499629185  68 IREFSDIPIIILNTIGEIGSKVQFLEDGADECIEKPINGIECQAVTNALLRRNMNLGFKAESTIPIS----NGLEVNFNR 143
Cdd:PRK11173  69 LREQANVALMFLTGRDNEVDKILGLEIGADDYITKPFNPRELTIRARNLLSRTMNLGTVSEERRSVEsykfNGWELDINS 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499629185 144 RELTQ-SGIPVHLTPIEFSLLALLARNSGQVLTYRMLLEKVWGTEysgdlnlLKKH-------IHNLRAKIEVNPEYPKI 215
Cdd:PRK11173 149 RSLISpDGEQYKLPRSEFRAMLHFCENPGKIQSRAELLKKMTGRE-------LKPHdrtvdvtIRRIRKHFESTPDTPEI 221


                 ....*....
gi 499629185 216 IVTERGLGY 224
Cdd:PRK11173 222 IATIHGEGY 230
PRK10766 PRK10766
two-component system response regulator TorR;
20-221 2.17e-10

two-component system response regulator TorR;


Pssm-ID: 182711 [Multi-domain]  Cd Length: 221  Bit Score: 58.51  E-value: 2.17e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499629185  20 LKIRYQNLEYTVSDNiTEGTGLIETLSP---DLIILDSYLLDSTTQNIIISIREFSDIPIIILNTIGEIGSKVQFLEDGA 96
Cdd:PRK10766  18 LQGYFEQEGYTVSEA-ASGAGMREIMQNqhvDLILLDINLPGEDGLMLTRELRSRSTVGIILVTGRTDSIDRIVGLEMGA 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499629185  97 DECIEKPINGIECQA-VTNALLRrnMNLGFKAESTIPIS------NGLEVNFNRRELTQSGIPVHLTPIEFSLLALLARN 169
Cdd:PRK10766  97 DDYVTKPLELRELLVrVKNLLWR--ISLARQAQPHAQEEdncyrfAGYCLNVSRRTLERNGEPIKLTKAEYELLVAFVTN 174

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 499629185 170 SGQVLTYRMLLEKVWGTEYSGDLNLLKKHIHNLRAKIEvnpeyPKIIVTERG 221
Cdd:PRK10766 175 PGQVLSRERLLRMLSHRVENPNDRTIDVLIRRLRHKLN-----PDLFVTQHG 221
REC_OmpR_PrrA-like cd17627
phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The ...
 3-119 3.21e-09

phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The Mycobacterium tuberculosis PrrA is part of the PrrA/PrrB two-component system (TCS) that has been implicated in early intracellular multiplication and is essential for viability. Also included in this subfamily is Mycobacterium tuberculosis MprA, part of the MprAB TCS that regulates EspR, a key regulator of the ESX-1 secretion system, and is required for establishment and maintenance of persistent infection in a tissue- and stage-specific fashion. PrrA and MprA belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381142 [Multi-domain]  Cd Length: 116  Bit Score: 53.16  E-value: 3.21e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499629185   3 ILIMCGDPQVLKDLVLCLkiRYQNLEYTVSDNITEGTGLIETLSPDLIILDSYL--LDSTTqnIIISIREF-SDIPIIIL 79
Cdd:cd17627    1 ILVVDDDRAVRESLRRSL--RFEGYEVETAVDGAEALRVISGNRPDAVVLDVMMprLDGLE--VCRRLRAAgNDLPILVL 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 499629185  80 NTIGEIGSKVQFLEDGADECIEKPINGIECQAVTNALLRR 119
Cdd:cd17627   77 TARDSVSDRVAGLDAGADDYLVKPFALEELLARVRALLRR 116
PRK15479 PRK15479
transcriptional regulator TctD;
73-229 4.09e-09

transcriptional regulator TctD;


Pssm-ID: 185376 [Multi-domain]  Cd Length: 221  Bit Score: 54.73  E-value: 4.09e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499629185  73 DIPIIILNTIGEIGSKVQFLEDGADECIEKPINGIECQAVTNALLRRNMNLGFKAESTIPISNGLEVNFnrrelTQSGIP 152
Cdd:PRK15479  72 TLPVLLLTARSAVADRVKGLNVGADDYLPKPFELEELDARLRALLRRSAGQVQEVQQLGELIFHDEGYF-----LLQGQP 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499629185 153 VHLTPIEFSLLALLARNSGQVLTYRMLLEKVWGTEYSGDLNLLKKHIHNLRAKI---EVNpeypkiIVTERGLGYSLIRQ 229
Cdd:PRK15479 147 LALTPREQALLTVLMYRRTRPVSRQQLFEQVFSLNDEVSPESIELYIHRLRKKLqgsDVR------ITTLRGLGYVLERG 220
REC_OmpR_CpxR cd17623
phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is ...
 37-119 1.06e-08

phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is part of the CpxA/CpxR two-component regulatory system that mediates envelope stress responses that is key for virulence and antibiotic resistance in several Gram negative pathogens. CpxR is a transcription factor/response regulator that controls the expression of numerous genes, including those of the classical porins OmpF and OmpC. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381138 [Multi-domain]  Cd Length: 115  Bit Score: 51.54  E-value: 1.06e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499629185  37 EGTGLIETLSPDLIILDSYLLDSTTQNIIISIREFSDIPIIILNTIGEIGSKVQFLEDGADECIEKPINGIECQAVTNAL 116
Cdd:cd17623   33 QGLAALLEGSPDLVVLDVMLPKMNGLDVLKELRKTSQVPVLMLTARGDDIDRILGLELGADDYLPKPFNPRELVARIRAI 112


                 ...
gi 499629185 117 LRR 119
Cdd:cd17623  113 LRR 115
REC_OmpR_YycF-like cd17614
phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF ...
 37-119 1.24e-08

phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF appears to play an important role in cell wall integrity in a wide range of gram-positive bacteria, and may also modulate cell membrane integrity. It functions as part of a phosphotransfer system that ultimately controls the levels of competence within the bacteria. YycF belongs to the OmpR family of response regulators, which are characterized by a REC domain and a winged helix-turn-helix effector domain involved in DNA binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381130 [Multi-domain]  Cd Length: 115  Bit Score: 51.66  E-value: 1.24e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499629185  37 EGTGLIETLSPDLIILDSYLLDSTTQNIIISIREFSDIPIIILNTIGEIGSKVQFLEDGADECIEKPINGIECQAVTNAL 116
Cdd:cd17614   33 EALEKVEEEQPDLILLDLMLPEKDGLEVCREVRKTSNVPIIMLTAKDSEVDKVLGLELGADDYVTKPFSNRELLARVKAN 112


                 ...
gi 499629185 117 LRR 119
Cdd:cd17614  113 LRR 115
PleD COG3706
Two-component response regulator, PleD family, consists of two REC domains and a diguanylate ...
 1-111 1.56e-08

Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 442920 [Multi-domain]  Cd Length: 179  Bit Score: 52.60  E-value: 1.56e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499629185   1 MKILIMCGDPQVLKdlVLCLKIRYQNLEYTVSDNITEGTGLIETLSPDLIILDSYL-----LDSTTQniIISIREFSDIP 75
Cdd:COG3706    2 ARILVVDDDPTNRK--LLRRLLEAAGYEVVEAADGEEALELLQEHRPDLILLDLEMpdmdgLELCRR--LRADPRTADIP 77

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 499629185  76 IIILNTIGEIGSKVQFLEDGADECIEKPINGIECQA 111
Cdd:COG3706   78 IIFLTALDDEEDRARALEAGADDYLTKPFDPEELLA 113
RpfG COG3437
Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains ...
 1-119 9.08e-08

Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains [Signal transduction mechanisms];


Pssm-ID: 442663 [Multi-domain]  Cd Length: 224  Bit Score: 50.93  E-value: 9.08e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499629185   1 MKILIMCGDPQVLKdlVLCLKIRYQNLEYTVSDNITEGTGLIETLSPDLIILDSYLLDSTTQNIIISIRE---FSDIPII 77
Cdd:COG3437    7 PTVLIVDDDPENLE--LLRQLLRTLGYDVVTAESGEEALELLLEAPPDLILLDVRMPGMDGFELLRLLRAdpsTRDIPVI 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 499629185  78 ILNTIGEIGSKVQFLEDGADECIEKPINGIECQAVTNALLRR 119
Cdd:COG3437   85 FLTALADPEDRERALEAGADDYLTKPFDPEELLARVRNALEL 126
REC cd00156
phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response ...
 9-103 2.74e-07

phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs); Two-component systems (TCSs) involving a sensor and a response regulator are used by bacteria to adapt to changing environments. Processes regulated by two-component systems in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Response regulators (RRs) share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. Response regulators regulate transcription, post-transcription or post-translation, or have functions such as methylesterases, adenylate or diguanylate cyclase, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases, and protein phosphatases, depending on their output domains. The function of some output domains are still unknown. TCSs are found in all three domains of life - bacteria, archaea, and eukaryotes, however, the presence and abundance of particular RRs vary between the lineages. Archaea encode very few RRs with DNA-binding output domains; most are stand-alone REC domains. Among eukaryotes, TCSs are found primarily in protozoa, fungi, algae, and green plants. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381085 [Multi-domain]  Cd Length: 99  Bit Score: 47.22  E-value: 2.74e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499629185   9 DPQVLKDLVLCLKIryQNLEYTVSDNITEGTGLIETLSPDLIILDSYLLDSTTQNIIISIRE-FSDIPIIILNTIGEIGS 87
Cdd:cd00156    6 DPAIRELLKSLLER--EGYEVDTAADGEEALELLREERPDLVLLDLMMPGMDGLELLRKLRElPPDIPVIVLTAKADEED 83

                         90
                 ....*....|....*.
gi 499629185  88 KVQFLEDGADECIEKP 103
Cdd:cd00156   84 AVRALELGADDYLVKP 99
REC_OmpR_BsPhoP-like cd19937
phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus ...
 28-118 3.26e-07

phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus subtilis PhoP (BsPhoP) is part of the PhoPR two-component system that participates in a signal transduction network that controls adaptation of the bacteria to phosphate deficiency by regulating (activating or repressing) genes of the Pho regulon upon phosphorylation by PhoR. When activated, PhoPR directs expression of phosphate scavenging enzymes, lowers synthesis of the phosphate-rich wall teichoic acid (WTA) and initiates synthesis of teichuronic acid, a non-phosphate containing replacement anionic polymer. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381164 [Multi-domain]  Cd Length: 116  Bit Score: 47.65  E-value: 3.26e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499629185  28 EYTVSDNITEGTGLIETLSPDLIILDSYL--LDS-TTQNIIISIREFSDIPIIILNTIGEIGSKVQFLEDGADECIEKPI 104
Cdd:cd19937   23 EVVTAYDGEEALKRAKDEKPDLIILDLMLpgIDGlEVCRILRSDPKTSSIPIIMLTAKGEEFDKVLGLELGADDYITKPF 102

                         90
                 ....*....|....
gi 499629185 105 NGIECQAVTNALLR 118
Cdd:cd19937  103 SPRELLARVKAVLR 116
CitB COG4565
DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal ...
 1-132 8.92e-07

DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal transduction mechanisms];


Pssm-ID: 443622 [Multi-domain]  Cd Length: 138  Bit Score: 46.89  E-value: 8.92e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499629185   1 MKILIMCGDPQVLKDLVLCLKIRYQNLEYTVSDNITEGTGLIETLSPDLIILDSYLLDSTTQNIIISIRE-FSDIPIIIL 79
Cdd:COG4565    4 IRVLIVEDDPMVAELLRRYLERLPGFEVVGVASSGEEALALLAEHRPDLILLDIYLPDGDGLELLRELRArGPDVDVIVI 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 499629185  80 NTIGEIGSKVQFLEDGADECIEKPINGIECQAVTNALLRRNMNLGFKAESTIP 132
Cdd:COG4565   84 TAARDPETVREALRAGVVDYLIKPFTFERLREALERYLEYRRLLREDQEEDLP 136
PRK10701 PRK10701
DNA-binding transcriptional regulator RstA; Provisional
 42-224 1.03e-06

DNA-binding transcriptional regulator RstA; Provisional


Pssm-ID: 236738 [Multi-domain]  Cd Length: 240  Bit Score: 48.09  E-value: 1.03e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499629185  42 IETLSPDLIILDSYLLDSTTQNIIISIREFSDIPIIILNTIGEIGSKVQFLEDGADECIEK---PingiecqAVTNALLR 118
Cdd:PRK10701  41 ILREQPDLVLLDIMLPGKDGMTICRDLRPKWQGPIVLLTSLDSDMNHILALEMGACDYILKttpP-------AVLLARLR 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499629185 119 ---RNMNLGFK----AESTIPISNGLE--------VNfnrRELTQSGIPVHLTPIEFSLLALLARNSGQVLTYRMLLEKV 183
Cdd:PRK10701 114 lhlRQNEQATQtkglQETSLTPYKALHfgtltidpVN---RQVTLAGEEISLSTADFDLLWELATHAGQIMDRDALLKNL 190

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 499629185 184 WGTEYSGDLNLLKKHIHNLRAKIEVNPEYPKIIVTERGLGY 224
Cdd:PRK10701 191 RGVSYDGLDRSVDVAISRLRKKLLDNAAEPYRIKTVRNKGY 231
REC_OmpR_PhoB cd17618
phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The ...
 41-117 2.00e-06

phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The transcription factor PhoB is a component of the PhoR/PhoB two-component system, a key regulatory protein network that facilitates response to inorganic phosphate (Pi) starvation conditions by turning on the phosphate (pho) regulon whose products are involved in phosphorus uptake and metabolism. PhoB is a member of the OmpR family of DNA-binding response regulators that contains REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381133 [Multi-domain]  Cd Length: 118  Bit Score: 45.32  E-value: 2.00e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499629185  41 LIETLSPDLIILDSYLLDSTTQNIIISIRE---FSDIPIIILNTIGEIGSKVQFLEDGADECIEKPINGIECQAVTNALL 117
Cdd:cd17618   39 LIVEPRPDLILLDWMLPGGSGIQFIRRLKRdemTRDIPIIMLTARGEEEDKVRGLEAGADDYITKPFSPRELVARIKAVL 118
AtoC COG2204
DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, ...
 1-131 7.89e-06

DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains [Signal transduction mechanisms];


Pssm-ID: 441806 [Multi-domain]  Cd Length: 418  Bit Score: 46.11  E-value: 7.89e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499629185   1 MKILIMCGDPQVLKDLVLCLkiRYQNLEYTVSDNITEGTGLIETLSPDLIILDSYLLDSTTQNIIISIRE-FSDIPIIIL 79
Cdd:COG2204    3 ARILVVDDDPDIRRLLKELL--ERAGYEVETAASGEEALALLREEPPDLVLLDLRMPGMDGLELLRELRAlDPDLPVILL 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 499629185  80 NTIGEIGSKVQFLEDGADECIEKPINGIE-CQAVTNALLRRNMNLGFKAESTI 131
Cdd:COG2204   81 TGYGDVETAVEAIKAGAFDYLTKPFDLEElLAAVERALERRRLRRENAEDSGL 133
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 3-105 8.88e-06

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 43.29  E-value: 8.88e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499629185    3 ILIMCGDPQVLKDLVLCLKIryQNLEYTVSDNITEGTGLIETLSPDLIILDSYL-----LDSTTQniiisIREFS-DIPI 76
Cdd:pfam00072   1 VLIVDDDPLIRELLRQLLEK--EGYVVAEADDGKEALELLKEERPDLILLDINMpgmdgLELLKR-----IRRRDpTTPV 73

                          90       100
                  ....*....|....*....|....*....
gi 499629185   77 IILNTIGEIGSKVQFLEDGADECIEKPIN 105
Cdd:pfam00072  74 IILTAHGDEDDAVEALEAGADDFLSKPFD 102
REC_OmpR_BfmR-like cd19939
phosphoacceptor receiver (REC) domain of BfmR-like OmpR family response regulators; ...
 42-119 2.40e-05

phosphoacceptor receiver (REC) domain of BfmR-like OmpR family response regulators; Acinetobacter baumannii BfmR is part of the BfmR/S two-component system that functions as the master regulator of biofilm initiation. BfmR confers resistance to complement-mediated bactericidal activity, independent of capsular polysaccharide, and also increases resistance to the clinically important antimicrobials meropenem and colistin, making it a potential antimicrobial target. Its inhibition would have the dual benefit of significantly decreasing in vivo survival and increasing sensitivity to selected antimicrobials. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381166 [Multi-domain]  Cd Length: 116  Bit Score: 42.36  E-value: 2.40e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499629185  42 IETLSPDLIILDSYL--LDSTTqnIIISIREFSDIPIIILNTIGEIGSKVQFLEDGADECIEKPINGIECQAVTNALLRR 119
Cdd:cd19939   39 IIDEQPSLVVLDIMLpgMDGLT--VCREVREHSHVPILMLTARTEEMDRVLGLEMGADDYLCKPFSPRELLARVRALLRR 116
REC_OmpR_MtrA-like cd17626
phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is ...
 35-117 2.46e-05

phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is part of MtrA/MtrB (or MtrAB), a highly conserved two-component system (TCS) implicated in the regulation of cell division in the actinobacteria. In unicellular Mycobacterium tuberculosis, MtrAB coordinates DNA replication with cell division and regulates the transcription of resuscitation-promoting factor B. In filamentous Streptomyces venezuelae, it links antibiotic production to sporulation. MtrA belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381141 [Multi-domain]  Cd Length: 115  Bit Score: 42.46  E-value: 2.46e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499629185  35 ITEGTGLIE---TLSPDLIILDSYLLDSTTQNIIISIREFSDIPIIILNTIGEIGSKVQFLEDGADECIEKPINGIECQA 111
Cdd:cd17626   30 CGDGTQALAafrEVRPDLVLLDLMLPGIDGIEVCRQIRAESGVPIVMLTAKSDTVDVVLGLESGADDYVAKPFKPKELVA 109


                 ....*.
gi 499629185 112 VTNALL 117
Cdd:cd17626  110 RIRARL 115
REC_OmpR_MtPhoP-like cd17615
phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; ...
 9-119 3.14e-05

phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; Mycobacterium tuberculosis PhoP (MtPhoP) is part of the PhoP/PhoR two-component system that is involved in phosphate control by stimulating expression of genes involved in scavenging, transport and mobilization of phosphate, and repressing the utilization of nitrogen sources. Also included in this subfamily is Mycobacterium tuberculosis transcriptional regulatory protein TcrX, part of the two-component regulatory system TcrY/TcrX that may be involved in virulence. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381131 [Multi-domain]  Cd Length: 118  Bit Score: 41.95  E-value: 3.14e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499629185   9 DPQVLKDLvLCLKIRYQNLEYTVSDNITEGTGLIETLSPDLIILDSYLLDSTTQNIIISIREFS-DIPIIILNTIGEIGS 87
Cdd:cd17615    7 DEPNITEL-LSMALRYEGWDVETAADGAEALAAAREFRPDAVVLDIMLPDMDGLEVLRRLRADGpDVPVLFLTAKDSVED 85

                         90       100       110
                 ....*....|....*....|....*....|..
gi 499629185  88 KVQFLEDGADECIEKPINGIECQAVTNALLRR 119
Cdd:cd17615   86 RIAGLTAGGDDYVTKPFSLEEVVARLRALLRR 117
REC_NtrC1-like cd17572
phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex ...
 25-122 3.58e-05

phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex aeolicus and similar NtrC family response regulators; NtrC family proteins are transcriptional regulators that have REC, AAA+ ATPase/sigma-54 interaction, and DNA-binding output domains. This subfamily of NtrC proteins include Aquifex aeolicus NtrC1 and Vibrio quorum-sensing signal integrator LuxO. The N-terminal REC domain of NtrC proteins regulate the activity of the protein and its phosphorylation controls the AAA+ domain oligomerization, while the central AAA+ domain participates in nucleotide binding, hydrolysis, oligomerization, and sigma54 interaction. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381114 [Multi-domain]  Cd Length: 121  Bit Score: 41.80  E-value: 3.58e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499629185  25 QNLEYTVSDNITEGTGLIETLSPDLIILDSYLLDSTTQNIIISIREFSD-IPIIILNTIGEIGSKVQFLEDGADECIEKP 103
Cdd:cd17572   21 EGYKVTHVETGKEALAFLSDQPPDVVLLDLKLPDMSGMEILKWIQERSLpTSVIVITAHGSVDIAVEAMRLGAYDFLEKP 100

                         90       100
                 ....*....|....*....|
gi 499629185 104 INGIE-CQAVTNALLRRNMN 122
Cdd:cd17572  101 FDADRlRVTVRNALKHRKLT 120
REC_OmpR_BaeR-like cd19938
phosphoacceptor receiver (REC) domain of BaeR-like OmpR family response regulators; BaeR is ...
 2-117 8.13e-05

phosphoacceptor receiver (REC) domain of BaeR-like OmpR family response regulators; BaeR is part of the BaeSR two-component system that is involved in regulating genes that confer multidrug and metal resistance. In Salmonella, BaeSR induces AcrD and MdtABC drug efflux systems, increasing multidrug and metal resistance. In Escherichia coli, BaeR stimulates multidrug resistance via mdtABC (multidrug transporter ABC, formerly known as yegMNO) genes, which encode a resistance-nodulation-cell division (RND) drug efflux system. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381165 [Multi-domain]  Cd Length: 114  Bit Score: 40.82  E-value: 8.13e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499629185   2 KILIMCGDPQVLKDLVLCLkiRYQNLEYTVSDNITEGTGLIETLSPDLIILDSYLLDSTTQNIIISIREFSDIPIIILNT 81
Cdd:cd19938    1 RILIVEDEPKLAQLLIDYL--RAAGYAPTLLAHGDQVLPYVRHTPPDLILLDLMLPGTDGLTLCREIRRFSDVPIIMVTA 78

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 499629185  82 IGEIGSKVQFLEDGADECIEKPINGIECQAVTNALL 117
Cdd:cd19938   79 RVEEIDRLLGLELGADDYICKPYSPREVVARVKAIL 114
REC_OmpR_DrrD-like cd17625
phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a ...
 48-119 1.82e-04

phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a OmpR/PhoB homolog from Thermotoga maritima whose function is not yet known. This subfamily also includes Streptococcus agalactiae transcriptional regulatory protein DltR, part of the DltS/DltR two-component system (TCS), and Pseudomonas aeruginosa transcriptional activator protein PfeR, part of the PfeR/PfeS TCS, which activates expression of the ferric enterobactin receptor. The DltS/DltR TCS regulates the expression of the dlt operon, which comprises four genes (dltA, dltB, dltC, and dltD) that catalyze the incorporation of D-alanine residues into the lipoteichoic acids. Members of this subfamily belong to the OmpR/PhoB family, which comprises of two domains, an N-terminal receiver domain and a C-terminal DNA-binding winged helix-turn-helix effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381140 [Multi-domain]  Cd Length: 115  Bit Score: 39.90  E-value: 1.82e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 499629185  48 DLIILDSYL--LDSTTqnIIISIREFS-DIPIIILNTIGEIGSKVQFLEDGADECIEKPINGIECQAVTNALLRR 119
Cdd:cd17625   43 DLIILDIMLpgMDGLE--VLKSLREEGiETPVLLLTALDAVEDRVKGLDLGADDYLPKPFSLAELLARIRALLRR 115
REC_OmpR cd17574
phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins ...
 41-103 2.99e-04

phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins are one of the most widespread transcriptional regulators. OmpR family members contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domain. They are involved in the control of environmental stress tolerance (such as the oxidative, osmotic and acid stress response), motility, virulence, outer membrane biogenesis and other processes. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381116 [Multi-domain]  Cd Length: 99  Bit Score: 38.93  E-value: 2.99e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 499629185  41 LIETLSPDLIILDSYL-----LDSTTQniiisIREF-SDIPIIILNTIGEIGSKVQFLEDGADECIEKP 103
Cdd:cd17574   36 LAREEQPDLIILDVMLpgmdgFEVCRR-----LREKgSDIPIIMLTAKDEEEDKVLGLELGADDYITKP 99
REC_OmpR_RegX3-like cd17621
phosphoacceptor receiver (REC) domain of RegX3-like OmpR family response regulators; RegX3 is ...
 18-103 3.81e-04

phosphoacceptor receiver (REC) domain of RegX3-like OmpR family response regulators; RegX3 is a member of the SenX3-RegX3 two-component system that is involved in phosphate-sensing signal transduction. Phosphorylated RegX3 functions as a transcriptional activator of phoA. It induces transcription in phosphate limiting environment and also controls expression of several critical metabolic enzymes in aerobic condition. RegX3 belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381136 [Multi-domain]  Cd Length: 99  Bit Score: 38.72  E-value: 3.81e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499629185  18 LCLKIRYQNLEYTVSDNITEGTGLIETLSPDLIILDSYLLDSTTQNIIISIREFSDIPIIILNTIGEIGSKVQFLEDGAD 97
Cdd:cd17621   14 LAYLLRKEGFEVTVATDGPAALAEFDRAGADIVLLDLMLPGLSGTEVCRQLRARSNVPVIMVTAKDSEIDKVVGLELGAD 93


                 ....*.
gi 499629185  98 ECIEKP 103
Cdd:cd17621   94 DYVTKP 99
CheY COG0784
CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator ...
 1-105 4.21e-04

CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator Spo0F [Signal transduction mechanisms];


Pssm-ID: 440547 [Multi-domain]  Cd Length: 128  Bit Score: 39.06  E-value: 4.21e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499629185   1 MKILIMCGDPQVLKDLVLCLkiryQNLEYTVS--DNITEGTGLIETLSPDLIILDSYL-----LDSTTQniIISIREFSD 73
Cdd:COG0784    6 KRILVVDDNPDNRELLRRLL----ERLGYEVTtaEDGAEALELLRAGPPDLILLDINMpgmdgLELLRR--IRALPRLPD 79

                         90       100       110
                 ....*....|....*....|....*....|..
gi 499629185  74 IPIIILNTIGEIGSKVQFLEDGADECIEKPIN 105
Cdd:COG0784   80 IPIIALTAYADEEDRERALEAGADDYLTKPVD 111
REC_RpfG-like cd17551
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator ...
 47-121 5.11e-04

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator RpfG and similar proteins; Cyclic di-GMP phosphodiesterase response regulator RpfG, together with sensory/regulatory protein RpfC, constitute a two-component system implicated in sensing and responding to the diffusible signal factor (DSF) that is essential for cell-cell signaling. RpfC is a hybrid sensor/histidine kinase that phosphorylates and activates RpfG, which degrades cyclic di-GMP to GMP, leading to the activation of Clp, a global transcriptional regulator that regulates a large set of genes in the DSF pathway. RpfG contains a CheY-like receiver domain attached to a histidine-aspartic acid-glycine-tyrosine-proline (HD-GYP) cyclic di-GMP phosphodiesterase domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381103 [Multi-domain]  Cd Length: 118  Bit Score: 38.58  E-value: 5.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499629185  47 PDLIILDsYL------LDSTTQniIISIREFSDIPIIILNTIGEIGSKVQFLEDGADECIEKPINGIECQAvtnallR-R 119
Cdd:cd17551   46 PDLILLD-YMmpgmdgLEFIRR--LRALPGLEDVPIVMITADTDREVRLRALEAGATDFLTKPFDPVELLA------RvR 116


                 ..
gi 499629185 120 NM 121
Cdd:cd17551  117 NL 118
REC_OmpR_EcPhoP-like cd19934
phosphoacceptor receiver (REC) domain of EcPhoP-like OmpR family response regulators; ...
 37-120 7.49e-04

phosphoacceptor receiver (REC) domain of EcPhoP-like OmpR family response regulators; Escherichia coli PhoP (EcPhoP) is part of the PhoQ/PhoP two-component system (TCS) that regulates virulence genes and plays an essential role in the response of the bacteria to the environment of their mammalian hosts, sensing several stimuli such as extracellular magnesium limitation, low pH, the presence of cationic antimicrobial peptides, and osmotic upshift. This subfamily also includes Brucella suis FeuP, part of the FeuPQ TCS that is involved in the regulation of iron uptake, and Microchaete diplosiphon RcaC, which is required for chromatic adaptation. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381161 [Multi-domain]  Cd Length: 117  Bit Score: 38.03  E-value: 7.49e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499629185  37 EGTGLIETLSPDLIILDSYLLDSTTQNIIISIREFS-DIPIIILNTIGEIGSKVQFLEDGADECIEKPINGIECQAVTNA 115
Cdd:cd19934   33 EALFQGEEEPYDLVVLDLGLPGMDGLSVLRRWRSEGrATPVLILTARDSWQDKVEGLDAGADDYLTKPFHIEELLARLRA 112


                 ....*
gi 499629185 116 LLRRN 120
Cdd:cd19934  113 LIRRA 117
REC_OmpR_CtrA cd17616
phosphoacceptor receiver (REC) domain of CtrA-like OmpR family response regulators; CtrA is ...
 3-117 2.21e-03

phosphoacceptor receiver (REC) domain of CtrA-like OmpR family response regulators; CtrA is part of the CckA-ChpT-CtrA phosphorelay that is conserved in alphaproteobacteria and is important in orchestrating the cell cycle, polar development, and flagellar biogenesis. CtrA is the master regulator of flagella synthesis genes and also regulates genes involved in the cell cycle, exopolysaccharide synthesis, and cyclic-di-GMP signaling. CtrA is active as a transcription factor when phosphorylated. It is a member of the OmpR family of DNA-binding response regulators, characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381132 [Multi-domain]  Cd Length: 114  Bit Score: 36.62  E-value: 2.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499629185   3 ILIMCGDPQVLKDLVLCLKIRYQNLEYTvsDNITEGTGLIETLSPDLIILDSYLLDSTTQNIIISIREFS-DIPIIILNT 81
Cdd:cd17616    1 VLLIEDDSATAQSIELMLKSEGFNVYTT--DLGEEGLDLGKLYDYDIILLDLNLPDMSGYEVLRTLRLAKvKTPILILSG 78

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 499629185  82 IGEIGSKVQFLEDGADECIEKPINGIECQAVTNALL 117
Cdd:cd17616   79 LADIEDKVKGLGFGADDYMTKPFHKDELVARIHAIV 114
REC_CheB-like cd17541
phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate ...
 41-108 2.44e-03

phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate methylesterase CheB and similar chemotaxis proteins; Methylesterase CheB is a chemotaxis response regulator with an N-terminal REC domain and a C-terminal methylesterase domain. Chemotaxis is a behavior known in motile bacteria that directs their movement in response to chemical gradients. CheB is a phosphorylation-activated response regulator involved in the reversible modification of bacterial chemotaxis receptors. It catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR. The CheB REC domain packs against the active site of the C-terminal domain and inhibits methylesterase activity by directly restricting access to the active site. Also included in this family is chemotaxis response regulator CheY, which contains a stand-alone REC domain, and an uncharacterized subfamily composed of proteins containing an N-terminal REC domain and a C-terminal CheY-P phosphatase (CheC) domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381096 [Multi-domain]  Cd Length: 125  Bit Score: 36.60  E-value: 2.44e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 499629185  41 LIETLSPDLIILDsyL----LD--STTQniiiSIREFSDIPIIILNTIGEIGSKVQF--LEDGADECIEKPINGIE 108
Cdd:cd17541   41 KIKELKPDVITLD--IempvMDglEALR----RIMAERPTPVVMVSSLTEEGAEITLeaLELGAVDFIAKPSGGIS 110
REC_OmpR_kpRstA-like cd17622
phosphoacceptor receiver (REC) domain of kpRstA-like OmpR family response regulators; ...
 42-118 2.67e-03

phosphoacceptor receiver (REC) domain of kpRstA-like OmpR family response regulators; Klebsiella pneumoniae RstA (kpRstA) is part of the RstA/RstB two-component regulatory system that may play a regulatory role in virulence. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381137 [Multi-domain]  Cd Length: 116  Bit Score: 36.59  E-value: 2.67e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 499629185  42 IETLSPDLIILDSYLLDSTTQNIIISIREFSDIPIIILNTIGEIGSKVQFLEDGADECIEKPINGIECQAVTNALLR 118
Cdd:cd17622   40 IAREKPDAVLLDIMLPGIDGLTLCRDLRPKYQGPILLLTALDSDIDHILGLELGADDYVVKPVEPAVLLARLRALLR 116
REC_OmpR_CusR-like cd19935
phosphoacceptor receiver (REC) domain of CusR-like OmpR family response regulators; ...
 29-103 3.27e-03

phosphoacceptor receiver (REC) domain of CusR-like OmpR family response regulators; Escherichia coli CusR is part of the CusS/CusR two-component system (TCS) that is involved in response to copper and silver. Other members of this subfamily include Escherichia coli PcoR, Pseudomonas syringae CopR, and Streptomyces coelicolor CutR, which are all transcriptional regulatory proteins and components of TCSs that regulate genes involved in copper resistance and/or metabolism. member of the subfamily is Escherichia coli HprR (hydrogen peroxide response regulator), previously called YdeW, which is part of the HprSR (or YedVW) TCS involved in stress response to hydrogen peroxide, as well as Cupriavidus metallidurans CzcR, which is part of the CzcS/CzcR TCS involved in the control of cobalt, zinc, and cadmium homeostasis. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381162 [Multi-domain]  Cd Length: 100  Bit Score: 35.88  E-value: 3.27e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499629185  29 YTV--SDNITEGTGLIETLSPDLIILDSYL--LDSTTqnIIISIRE-FSDIPIIILNTIGEIGSKVQFLEDGADECIEKP 103
Cdd:cd19935   23 YAVdvAYDGEDGLHLALTNEYDLIILDVMLpgLDGLE--VLRRLRAaGKQTPVLMLTARDSVEDRVKGLDLGADDYLVKP 100
AmiR COG3707
Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding ...
 1-105 3.94e-03

Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding antiterminator (ANTAR) domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 442921 [Multi-domain]  Cd Length: 194  Bit Score: 37.24  E-value: 3.94e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499629185   1 MKILIMCGDPQVLKDLVLCLkiryQNLEYTVSDNITEGTGLIE---TLSPDLIILDSYLLDSTTQNIIISIREFSDIPII 77
Cdd:COG3707    4 LRVLVVDDEPLRRADLREGL----REAGYEVVAEAADGEDAVElvrELKPDLVIVDIDMPDRDGLEAARQISEERPAPVI 79

                         90       100
                 ....*....|....*....|....*...
gi 499629185  78 ILNTIGEIGSKVQFLEDGADECIEKPIN 105
Cdd:COG3707   80 LLTAYSDPELIERALEAGVSAYLVKPLD 107
REC_OmpR_PmrA-like cd17624
phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This ...
 41-118 4.02e-03

phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This subfamily contains various OmpR family response regulators including PmrA, BasR, QseB, tctD, and RssB, which are components of two-component regulatory systems (TCSs). The PmrA/PmrB TCS controls transcription of genes that are involved in lipopolysaccharide modification in the outer membrane of bacteria, increasing bacterial resistance to host-derived antimicrobial peptides. The BasS/BasR TCS functions as an iron- and zinc-sensing transcription regulator. The QseB/QseC TCS activates the flagella regulon by activating transcription of FlhDC. The RssA/RssB TCS regulates swarming behavior in Serratia marcescens. OmpR family DNA-binding response regulators contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381139 [Multi-domain]  Cd Length: 115  Bit Score: 35.92  E-value: 4.02e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 499629185  41 LIETLSPDLIILDSYLLDSTTQNIIISIR-EFSDIPIIILNTIGEIGSKVQFLEDGADECIEKPINGIECQAVTNALLR 118
Cdd:cd17624   37 ALASGPYDLVILDLGLPDGDGLDLLRRWRrQGQSLPVLILTARDGVDDRVAGLDAGADDYLVKPFALEELLARLRALLR 115
REC_OmpR_VirG cd17594
phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is ...
 9-115 9.18e-03

phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is part of the VirA/VirG two-component system that regulates the expression of virulence (vir) genes. The histidine kinase VirA senses a phenolic wound response signal, undergoes autophosphorylation, and phosphorelays to the VirG response regulator, which induces transcription of the vir regulon. VirG belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381125 [Multi-domain]  Cd Length: 113  Bit Score: 35.11  E-value: 9.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499629185   9 DPQVLKDLVLcLKIRYQNLEYTVSDNITEGTGLIETLSPDLIILDSYLLDSTTQNIIISIREFSDIPIIIL--NTIGEIg 86
Cdd:cd17594    7 DDAAMRHLLI-LYLRERGFDVTAAADGAEEARLMLHRRVDLVLLDLRLGQESGLDLLRTIRARSDVPIIIIsgDRRDEI- 84

                         90       100
                 ....*....|....*....|....*....
gi 499629185  87 SKVQFLEDGADECIEKPINGIECQAVTNA 115
Cdd:cd17594   85 DRVVGLELGADDYLAKPFGLRELLARVRA 113
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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