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Conserved domains on  [gi|499657019|ref|WP_011337753|]
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TetR/AcrR family transcriptional regulator [Cereibacter sphaeroides]

Protein Classification

TetR/AcrR family transcriptional regulator( domain architecture ID 11442015)

TetR/AcrR family transcriptional regulator may control genes involved in one of a variety of processes including antibiotic production, osmotic stress response, efflux pump expression, and multidrug resistance

CATH:  1.10.10.60|1.10.357.10
Gene Ontology:  GO:0003700|GO:0003677|GO:0006355
PubMed:  23602932
SCOP:  4000333

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
10-139 4.35e-21

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


:

Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 85.34  E-value: 4.35e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499657019  10 RGDEILDQIRGTFAEKGFDGASMQDLARAAGMSVGNFYRYFPSKAAIVEAIVRRDLEGVERDFAAVVSSDDPMARLREIL 89
Cdd:COG1309    7 TRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALEEALAAEDPRERLRALL 86

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 499657019  90 RYRieVELCEEDAPLWAEITAMAHRNPEIAGICERMETEIRRAFLGIFAR 139
Cdd:COG1309   87 RAY--LEFLAENPALARLLLAEAAELPELRAALRALLRRLRALLAELLRA 134
 
Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
10-139 4.35e-21

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 85.34  E-value: 4.35e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499657019  10 RGDEILDQIRGTFAEKGFDGASMQDLARAAGMSVGNFYRYFPSKAAIVEAIVRRDLEGVERDFAAVVSSDDPMARLREIL 89
Cdd:COG1309    7 TRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALEEALAAEDPRERLRALL 86

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 499657019  90 RYRieVELCEEDAPLWAEITAMAHRNPEIAGICERMETEIRRAFLGIFAR 139
Cdd:COG1309   87 RAY--LEFLAENPALARLLLAEAAELPELRAALRALLRRLRALLAELLRA 134
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
14-60 2.10e-13

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 62.04  E-value: 2.10e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 499657019   14 ILDQIRGTFAEKGFDGASMQDLARAAGMSVGNFYRYFPSKAAIVEAI 60
Cdd:pfam00440   1 ILDAARELFAERGYDATTVREIAKRAGVSKGALYRYFGSKEELLEAL 47
mycofact_TetR TIGR03968
mycofactocin system transcriptional regulator; Members of this family are TetR family putative ...
 22-89 2.83e-07

mycofactocin system transcriptional regulator; Members of this family are TetR family putative transcriptional regulators that occur in genome contexts near proteins of the mycofactocin system. These include the precursor peptide (TIGR03969), a radical SAM peptide maturase (TIGR03962), and a putative carrier protein (TIGR03967). [Regulatory functions, DNA interactions]


Pssm-ID: 188483 [Multi-domain]  Cd Length: 190  Bit Score: 48.85  E-value: 2.83e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 499657019   22 FAEKGFDGASMQDLARAAGMSVGNFYRYFPSKAAIVEAIVRRDLEGVERDFAAVVSSDDPMARLREIL 89
Cdd:TIGR03968  22 FTERGFDETTVDDIAAAAGIARRTFFRYFASKNDVPWGDFDAHLDALRALLAATPDDLPVMDALRRAV 89
PRK15008 PRK15008
HTH-type transcriptional regulator RutR; Provisional
 4-95 9.39e-07

HTH-type transcriptional regulator RutR; Provisional


Pssm-ID: 184970 [Multi-domain]  Cd Length: 212  Bit Score: 47.62  E-value: 9.39e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499657019   4 SSAPVPRGDEILDQIRGTFAEKGFDGASMQDLARAAGMSVGNFYRYFPSKAAIVEAIVRRDLEGVERDFAAVVSSDDPMA 83
Cdd:PRK15008  13 SRAVSAKKKAILSAALDTFSQFGFHGTRLEQIAELAGVSKTNLLYYFPSKEALYIAVLRQILDIWLAPLKAFREDFAPLA 92

                         90
                 ....*....|..
gi 499657019  84 RLREILRYRIEV 95
Cdd:PRK15008  93 AIKEYIRLKLEV 104
ScbR_bind_reg NF041196
ScbR family autoregulator-binding transcription factor;
22-70 6.42e-06

ScbR family autoregulator-binding transcription factor;


Pssm-ID: 469100 [Multi-domain]  Cd Length: 191  Bit Score: 44.89  E-value: 6.42e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 499657019  22 FAEKGFDGASMQDLARAAGMSVGNFYRYFPSK----AAIVEAIVRRDLEGVER 70
Cdd:NF041196  19 FDERGYAAATISDILERAGVTKGALYFHFSSKealaRAVLEEQVARLREAVEP 71
 
Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
10-139 4.35e-21

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 85.34  E-value: 4.35e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499657019  10 RGDEILDQIRGTFAEKGFDGASMQDLARAAGMSVGNFYRYFPSKAAIVEAIVRRDLEGVERDFAAVVSSDDPMARLREIL 89
Cdd:COG1309    7 TRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALEEALAAEDPRERLRALL 86

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 499657019  90 RYRieVELCEEDAPLWAEITAMAHRNPEIAGICERMETEIRRAFLGIFAR 139
Cdd:COG1309   87 RAY--LEFLAENPALARLLLAEAAELPELRAALRALLRRLRALLAELLRA 134
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
14-60 2.10e-13

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 62.04  E-value: 2.10e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 499657019   14 ILDQIRGTFAEKGFDGASMQDLARAAGMSVGNFYRYFPSKAAIVEAI 60
Cdd:pfam00440   1 ILDAARELFAERGYDATTVREIAKRAGVSKGALYRYFGSKEELLEAL 47
YbjK COG3226
DNA-binding transcriptional regulator YbjK [Transcription];
23-145 7.40e-08

DNA-binding transcriptional regulator YbjK [Transcription];


Pssm-ID: 442459 [Multi-domain]  Cd Length: 191  Bit Score: 50.71  E-value: 7.40e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499657019  23 AEKGFDGASMQDLARAAGMSVGNFYRYFPSKAAIVEAIVRRDLEGVERDFAAVVSSDDPMARLREILRYRIE--VELCEE 100
Cdd:COG3226   22 ARDGVRGVTHRAVAAEAGVPLGSTTYYFRTRDELLAAAFERLAEREAARLRALLAAADDLEDAAEALADLLAelLPADRD 101

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 499657019 101 DAPLWAEITAMAHRNPEIAGICERMETEIRRAFLGIFARVTGQPP 145
Cdd:COG3226  102 RLLARYELYLEALRDPELRALLRRWRDRLREALARLLAALGSPDP 146
mycofact_TetR TIGR03968
mycofactocin system transcriptional regulator; Members of this family are TetR family putative ...
 22-89 2.83e-07

mycofactocin system transcriptional regulator; Members of this family are TetR family putative transcriptional regulators that occur in genome contexts near proteins of the mycofactocin system. These include the precursor peptide (TIGR03969), a radical SAM peptide maturase (TIGR03962), and a putative carrier protein (TIGR03967). [Regulatory functions, DNA interactions]


Pssm-ID: 188483 [Multi-domain]  Cd Length: 190  Bit Score: 48.85  E-value: 2.83e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 499657019   22 FAEKGFDGASMQDLARAAGMSVGNFYRYFPSKAAIVEAIVRRDLEGVERDFAAVVSSDDPMARLREIL 89
Cdd:TIGR03968  22 FTERGFDETTVDDIAAAAGIARRTFFRYFASKNDVPWGDFDAHLDALRALLAATPDDLPVMDALRRAV 89
PRK15008 PRK15008
HTH-type transcriptional regulator RutR; Provisional
 4-95 9.39e-07

HTH-type transcriptional regulator RutR; Provisional


Pssm-ID: 184970 [Multi-domain]  Cd Length: 212  Bit Score: 47.62  E-value: 9.39e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499657019   4 SSAPVPRGDEILDQIRGTFAEKGFDGASMQDLARAAGMSVGNFYRYFPSKAAIVEAIVRRDLEGVERDFAAVVSSDDPMA 83
Cdd:PRK15008  13 SRAVSAKKKAILSAALDTFSQFGFHGTRLEQIAELAGVSKTNLLYYFPSKEALYIAVLRQILDIWLAPLKAFREDFAPLA 92

                         90
                 ....*....|..
gi 499657019  84 RLREILRYRIEV 95
Cdd:PRK15008  93 AIKEYIRLKLEV 104
ScbR_bind_reg NF041196
ScbR family autoregulator-binding transcription factor;
22-70 6.42e-06

ScbR family autoregulator-binding transcription factor;


Pssm-ID: 469100 [Multi-domain]  Cd Length: 191  Bit Score: 44.89  E-value: 6.42e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 499657019  22 FAEKGFDGASMQDLARAAGMSVGNFYRYFPSK----AAIVEAIVRRDLEGVER 70
Cdd:NF041196  19 FDERGYAAATISDILERAGVTKGALYFHFSSKealaRAVLEEQVARLREAVEP 71
PRK10668 PRK10668
DNA-binding transcriptional repressor AcrR; Provisional
 14-108 2.01e-04

DNA-binding transcriptional repressor AcrR; Provisional


Pssm-ID: 182632 [Multi-domain]  Cd Length: 215  Bit Score: 40.76  E-value: 2.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499657019  14 ILDQIRGTFAEKGFDGASMQDLARAAGMSVGNFYRYFPSKAAIVEAIVRR---DLEGVERDFAAVVsSDDPMARLREILR 90
Cdd:PRK10668  16 ILDAALRLFSQQGVSATSLADIAKAAGVTRGAIYWHFKNKSDLFSEIWELsesKIGELELEYQAKF-PDDPLSVLREILI 94

                         90
                 ....*....|....*...
gi 499657019  91 YRIEVELCEEDAPLWAEI 108
Cdd:PRK10668  95 YILEATVTDERRRLLMEI 112
PRK09975 PRK09975
DNA-binding transcriptional regulator EnvR; Provisional
 21-91 5.08e-03

DNA-binding transcriptional regulator EnvR; Provisional


Pssm-ID: 182177 [Multi-domain]  Cd Length: 213  Bit Score: 36.64  E-value: 5.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499657019  21 TFAEKGFDGASMQDLARAAGMSVGNFYRYFPSKAAIVEAIVR-----RDLegvERDFAAVVSSDDPMARLRE----ILRY 91
Cdd:PRK09975  23 QFALRGVSNTTLNDIADAANVTRGAIYWHFENKTQLFNEMWLqqpplREL---IQEHLTAGLEHDPLQQLREkfiaGLQY 99
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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