|
Name |
Accession |
Description |
Interval |
E-value |
| COG5001 |
COG5001 |
Cyclic di-GMP metabolism protein, combines GGDEF and EAL domains with a 6TM membrane domain ... |
91-761 |
2.00e-176 |
|
Cyclic di-GMP metabolism protein, combines GGDEF and EAL domains with a 6TM membrane domain [Signal transduction mechanisms];
Pssm-ID: 444025 [Multi-domain] Cd Length: 678 Bit Score: 522.03 E-value: 2.00e-176
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 91 AQRALLRETRELLQQQQASTVWDESVVHVRAGDRDWIDSNLGTWMHEEYGQDETYIVDPASRIVYVARERVTGQPGPRAT 170
Cdd:COG5001 2 LALAALLLLLLALLLALLLLALLLLALLLAALLALALLLLLLLLLLALLLAALLLLALLALLALLLLAAALLALALAALL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 171 LPPAVEEMVEEMRPMMRAATRNRADSTADVADLSLSRFVLLGGKPALVSVVPIVPDTPAVVQAAGteylhVAVQMADADM 250
Cdd:COG5001 82 LAALLAALLLLLLLLLALLVLLLLLLLLLALLALLAALLARALAALLLAAASAALLAAALGAALL-----AALALALLLA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 251 AARLSNTYEFDRGSFSVQPGPEDRLSVPLRDGAGRPIAWFVWRADRPGHRIVDEMLPVVGLFAAFGAALLTWLLRTLWTA 330
Cdd:COG5001 157 LARALLALLLLLLLALLLLLLLLLLLALLLLLLLALLLRLLLLLRGGRLLRLALRLLLGLLLLGLLLLLLLVAVLAIARL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 331 SRRLHQSEEEARYLAMHDPLAGIPNRTLFEDRLDQALKAERRGGPPVALLCLDLDRFKAVNDTMGHQAGDELIRQMAARL 410
Cdd:COG5001 237 ITERKRAEERLRHLAYHDPLTGLPNRRLFLDRLEQALARARRSGRRLALLFIDLDRFKEINDTLGHAAGDELLREVARRL 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 411 RSHVRETDTVARLGGDEFGVILIGMASDETLGRYCSGLVHLLAAPCDLKCGQVQIGASIGAVRAASVDGGREAILRSADT 490
Cdd:COG5001 317 RACLREGDTVARLGGDEFAVLLPDLDDPEDAEAVAERILAALAEPFELDGHELYVSASIGIALYPDDGADAEELLRNADL 396
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 491 ALYRAKAEGRGRYCIATPEMNDIFRRRHEIERDLREAVAEgGQIHVLYQPIFDAE-ERIVAAEALVRWNHPILGQMGPET 569
Cdd:COG5001 397 AMYRAKAAGRNRYRFFDPEMDERARERLELEADLRRALER-GELELHYQPQVDLAtGRIVGAEALLRWQHPERGLVSPAE 475
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 570 FLSIAEETGLIDRIGHHVLEQACILAAT---SGIP--RVSVNISPVQLRQETFADEVLAVMAAHSLSGERLVLELTEKFT 644
Cdd:COG5001 476 FIPLAEETGLIVPLGEWVLREACRQLAAwqdAGLPdlRVAVNLSARQLRDPDLVDRVRRALAETGLPPSRLELEITESAL 555
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 645 LDAGPATLANLARLRAAGVSIALDDFATGQSLLRYVRDYQIDTIKIDRSYVARLGTGDGTDQIVRAILDLGRAMGIEVTA 724
Cdd:COG5001 556 LEDPEEALETLRALRALGVRIALDDFGTGYSSLSYLKRLPVDTLKIDRSFVRDLAEDPDDAAIVRAIIALAHSLGLEVVA 635
|
650 660 670
....*....|....*....|....*....|....*..
gi 499658306 725 EGVERASQREALLGMGCHGFQGYLLGRPMDPLRLAAL 761
Cdd:COG5001 636 EGVETEEQLEFLRELGCDYAQGYLFSRPLPAEELEAL 672
|
|
| EAL |
cd01948 |
EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL ... |
522-755 |
4.24e-89 |
|
EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second messenger, cyclic di-GMP, and is a good candidate for a diguanylate phosphodiesterase function. Together with the GGDEF domain, EAL might be involved in regulating cell surface adhesiveness in bacteria.
Pssm-ID: 238923 [Multi-domain] Cd Length: 240 Bit Score: 280.20 E-value: 4.24e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 522 RDLREAVAEGgQIHVLYQPIFDAEE-RIVAAEALVRWNHPILGQMGPETFLSIAEETGLIDRIGHHVLEQACILAAT--- 597
Cdd:cd01948 1 ADLRRALERG-EFELYYQPIVDLRTgRIVGYEALLRWRHPEGGLISPAEFIPLAEETGLIVELGRWVLEEACRQLARwqa 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 598 -SGIPRVSVNISPVQLRQETFADEVLAVMAAHSLSGERLVLELTEKFTLDAGPATLANLARLRAAGVSIALDDFATGQSL 676
Cdd:cd01948 80 gGPDLRLSVNLSARQLRDPDFLDRLLELLAETGLPPRRLVLEITESALIDDLEEALATLRRLRALGVRIALDDFGTGYSS 159
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 499658306 677 LRYVRDYQIDTIKIDRSYVARLGTGDGTDQIVRAILDLGRAMGIEVTAEGVERASQREALLGMGCHGFQGYLLGRPMDP 755
Cdd:cd01948 160 LSYLKRLPVDYLKIDRSFVRDIETDPEDRAIVRAIIALAHSLGLKVVAEGVETEEQLELLRELGCDYVQGYLFSRPLPA 238
|
|
| EAL |
smart00052 |
Putative diguanylate phosphodiesterase; Putative diguanylate phosphodiesterase, present in a ... |
521-753 |
3.73e-80 |
|
Putative diguanylate phosphodiesterase; Putative diguanylate phosphodiesterase, present in a variety of bacteria.
Pssm-ID: 214491 [Multi-domain] Cd Length: 242 Bit Score: 256.76 E-value: 3.73e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 521 ERDLREAVAEGgQIHVLYQPIFDAEE-RIVAAEALVRWNHPILGQMGPETFLSIAEETGLIDRIGHHVLEQAC-----IL 594
Cdd:smart00052 1 ERELRQALENG-QFLLYYQPIVSLRTgRLVGVEALIRWQHPEGGIISPDEFIPLAEETGLIVPLGRWVLEQACqqlaeWQ 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 595 AATSGIPRVSVNISPVQLRQETFADEVLAVMAAHSLSGERLVLELTEKFTLDAGPATLANLARLRAAGVSIALDDFATGQ 674
Cdd:smart00052 80 AQGPPPLLISINLSARQLISPDLVPRVLELLEETGLPPQRLELEITESVLLDDDESAVATLQRLRELGVRIALDDFGTGY 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 675 SLLRYVRDYQIDTIKIDRSYVARLGTgDGTDQ-IVRAILDLGRAMGIEVTAEGVERASQREALLGMGCHGFQGYLLGRPM 753
Cdd:smart00052 160 SSLSYLKRLPVDLLKIDKSFVRDLQT-DPEDEaIVQSIIELAQKLGLQVVAEGVETPEQLDLLRSLGCDYGQGYLFSRPL 238
|
|
| PRK10060 |
PRK10060 |
cyclic di-GMP phosphodiesterase; |
337-753 |
1.11e-79 |
|
cyclic di-GMP phosphodiesterase;
Pssm-ID: 236645 [Multi-domain] Cd Length: 663 Bit Score: 268.86 E-value: 1.11e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 337 SEEEARYLAMHDPLAGIPNRTLFEDRLDQALkaERRGGPPVALLCLDLDRFKAVNDTMGHQAGDELIRQMAARLRSHVRE 416
Cdd:PRK10060 229 AQERLRILANTDSITGLPNRNAIQELIDHAI--NAADNNQVGIVYLDLDNFKKVNDAYGHMFGDQLLQDVSLAILSCLEE 306
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 417 TDTVARLGGDEFgVILIGMASDETLGRYCSGLVHLLAAPCDLKCGQVQIGASIGAVRAASVDGGREAILRSADTALYRAK 496
Cdd:PRK10060 307 DQTLARLGGDEF-LVLASHTSQAALEAMASRILTRLRLPFRIGLIEVYTGCSIGIALAPEHGDDSESLIRSADTAMYTAK 385
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 497 AEGRGRYCIATPEMNDIFRRRHEIERDLREAVaEGGQIHVLYQPIFDAEERIVAAEALVRWNHPILGQMGPETFLSIAEE 576
Cdd:PRK10060 386 EGGRGQFCVFSPEMNQRVFEYLWLDTNLRKAL-ENDQLVIHYQPKITWRGEVRSLEALVRWQSPERGLIPPLEFISYAEE 464
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 577 TGLIDRIGHHVLEQACILAA---TSGIP-RVSVNISPVQLRQETFADEVLAVMAAHSLSGERLVLELTEKFTLDAGPATL 652
Cdd:PRK10060 465 SGLIVPLGRWVMLDVVRQVAkwrDKGINlRVAVNVSARQLADQTIFTALKQALQELNFEYCPIDVELTESCLIENEELAL 544
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 653 ANLARLRAAGVSIALDDFATGQSLLRYVRDYQIDTIKIDRSYVARLGTGDGTDQIVRAILDLGRAMGIEVTAEGVERASQ 732
Cdd:PRK10060 545 SVIQQFSQLGAQVHLDDFGTGYSSLSQLARFPIDAIKLDQSFVRDIHKQPVSQSLVRAIVAVAQALNLQVIAEGVETAKE 624
|
410 420
....*....|....*....|.
gi 499658306 733 REALLGMGCHGFQGYLLGRPM 753
Cdd:PRK10060 625 DAFLTKNGVNERQGFLFAKPM 645
|
|
| EAL |
pfam00563 |
EAL domain; This domain is found in diverse bacterial signaling proteins. It is called EAL ... |
521-752 |
7.06e-65 |
|
EAL domain; This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues. The EAL domain is a good candidate for a diguanylate phosphodiesterase function. The domain contains many conserved acidic residues that could participate in metal binding and might form the phosphodiesterase active site.
Pssm-ID: 425752 [Multi-domain] Cd Length: 235 Bit Score: 215.64 E-value: 7.06e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 521 ERDLREAVaEGGQIHVLYQPIFDAEE-RIVAAEALVRWNHPILGQMGPETFLSIAEETGLIDRIGHHVLEQAC-ILAATS 598
Cdd:pfam00563 1 ARALRRAL-ENGEFVLYYQPIVDLRTgRVVGYEALLRWQHPDGGLISPARFLPLAEELGLIAELDRWVLEQALaDLAQLQ 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 599 GIP--RVSVNISPVQLRQETFADEVLAVMAAHSLSGERLVLELTEKFTLDAGPATLANLARLRAAGVSIALDDFATGQSL 676
Cdd:pfam00563 80 LGPdiKLSINLSPASLADPGFLELLRALLKQAGPPPSRLVLEITESDLLARLEALREVLKRLRALGIRIALDDFGTGYSS 159
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 499658306 677 LRYVRDYQIDTIKIDRSYVARLGTGDGTDQIVRAILDLGRAMGIEVTAEGVERASQREALLGMGCHGFQGYLLGRP 752
Cdd:pfam00563 160 LSYLLRLPPDFVKIDRSLIADIDKDGEARAIVRALIALAHSLGIKVVAEGVETEEQLEALRELGCDLVQGYYFSKP 235
|
|
| GGDEF |
TIGR00254 |
diguanylate cyclase (GGDEF) domain; The GGDEF domain is named for the motif GG[DE]EF shared by ... |
344-503 |
1.76e-39 |
|
diguanylate cyclase (GGDEF) domain; The GGDEF domain is named for the motif GG[DE]EF shared by many proteins carrying the domain. There is evidence that the domain has diguanylate cyclase activity. Several proteins carrying this domain also carry domains with functions relating to environmental sensing. These include PleD, a response regulator protein involved in the swarmer-to-stalked cell transition in Caulobacter crescentus, and FixL, a heme-containing oxygen sensor protein. [Regulatory functions, Small molecule interactions, Signal transduction, Other]
Pssm-ID: 272984 [Multi-domain] Cd Length: 165 Bit Score: 143.25 E-value: 1.76e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 344 LAMHDPLAGIPNRTLFEDRLDQALKAERRGGPPVALLCLDLDRFKAVNDTMGHQAGDELIRQMAARLRSHVRETDTVARL 423
Cdd:TIGR00254 1 QAVRDPLTGLYNRRYLEEMLDSELKRARRFQRSFSVLMIDIDNFKKINDTLGHDVGDEVLREVARILQSSVRGSDVVGRY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 424 GGDEFGVILIGMASDETLGRYCSGLVHLLAAPCDLKCG-QVQIGASIGAvrAASVDGGR--EAILRSADTALYRAKAEGR 500
Cdd:TIGR00254 81 GGEEFVVILPGTPLEDALSKAERLRDAINSKPIEVAGSeTLTVTVSIGV--ACYPGHGLtlEELLKRADEALYQAKKAGR 158
|
...
gi 499658306 501 GRY 503
Cdd:TIGR00254 159 NRV 161
|
|
| diguan_DgcJ |
NF040885 |
diguanylate cyclase DgcJ; |
348-433 |
1.40e-15 |
|
diguanylate cyclase DgcJ;
Pssm-ID: 468821 [Multi-domain] Cd Length: 490 Bit Score: 80.00 E-value: 1.40e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 348 DPLAGIPNRTLFEDRLDQALKAERRGGPPVALLCLDLDRFKAVNDTMGHQAGDELIRQMAARLRSHVRETDTVARLGGDE 427
Cdd:NF040885 344 DSMTGLYNRKILTPTLEQRLQRLTEKGIPVTFIALDCDKLKHINDTLGHHEGDRAITLLAQAISASIRKSDYGIRLGGDE 423
|
....*.
gi 499658306 428 FGVILI 433
Cdd:NF040885 424 FCIILI 429
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| COG5001 |
COG5001 |
Cyclic di-GMP metabolism protein, combines GGDEF and EAL domains with a 6TM membrane domain ... |
91-761 |
2.00e-176 |
|
Cyclic di-GMP metabolism protein, combines GGDEF and EAL domains with a 6TM membrane domain [Signal transduction mechanisms];
Pssm-ID: 444025 [Multi-domain] Cd Length: 678 Bit Score: 522.03 E-value: 2.00e-176
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 91 AQRALLRETRELLQQQQASTVWDESVVHVRAGDRDWIDSNLGTWMHEEYGQDETYIVDPASRIVYVARERVTGQPGPRAT 170
Cdd:COG5001 2 LALAALLLLLLALLLALLLLALLLLALLLAALLALALLLLLLLLLLALLLAALLLLALLALLALLLLAAALLALALAALL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 171 LPPAVEEMVEEMRPMMRAATRNRADSTADVADLSLSRFVLLGGKPALVSVVPIVPDTPAVVQAAGteylhVAVQMADADM 250
Cdd:COG5001 82 LAALLAALLLLLLLLLALLVLLLLLLLLLALLALLAALLARALAALLLAAASAALLAAALGAALL-----AALALALLLA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 251 AARLSNTYEFDRGSFSVQPGPEDRLSVPLRDGAGRPIAWFVWRADRPGHRIVDEMLPVVGLFAAFGAALLTWLLRTLWTA 330
Cdd:COG5001 157 LARALLALLLLLLLALLLLLLLLLLLALLLLLLLALLLRLLLLLRGGRLLRLALRLLLGLLLLGLLLLLLLVAVLAIARL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 331 SRRLHQSEEEARYLAMHDPLAGIPNRTLFEDRLDQALKAERRGGPPVALLCLDLDRFKAVNDTMGHQAGDELIRQMAARL 410
Cdd:COG5001 237 ITERKRAEERLRHLAYHDPLTGLPNRRLFLDRLEQALARARRSGRRLALLFIDLDRFKEINDTLGHAAGDELLREVARRL 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 411 RSHVRETDTVARLGGDEFGVILIGMASDETLGRYCSGLVHLLAAPCDLKCGQVQIGASIGAVRAASVDGGREAILRSADT 490
Cdd:COG5001 317 RACLREGDTVARLGGDEFAVLLPDLDDPEDAEAVAERILAALAEPFELDGHELYVSASIGIALYPDDGADAEELLRNADL 396
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 491 ALYRAKAEGRGRYCIATPEMNDIFRRRHEIERDLREAVAEgGQIHVLYQPIFDAE-ERIVAAEALVRWNHPILGQMGPET 569
Cdd:COG5001 397 AMYRAKAAGRNRYRFFDPEMDERARERLELEADLRRALER-GELELHYQPQVDLAtGRIVGAEALLRWQHPERGLVSPAE 475
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 570 FLSIAEETGLIDRIGHHVLEQACILAAT---SGIP--RVSVNISPVQLRQETFADEVLAVMAAHSLSGERLVLELTEKFT 644
Cdd:COG5001 476 FIPLAEETGLIVPLGEWVLREACRQLAAwqdAGLPdlRVAVNLSARQLRDPDLVDRVRRALAETGLPPSRLELEITESAL 555
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 645 LDAGPATLANLARLRAAGVSIALDDFATGQSLLRYVRDYQIDTIKIDRSYVARLGTGDGTDQIVRAILDLGRAMGIEVTA 724
Cdd:COG5001 556 LEDPEEALETLRALRALGVRIALDDFGTGYSSLSYLKRLPVDTLKIDRSFVRDLAEDPDDAAIVRAIIALAHSLGLEVVA 635
|
650 660 670
....*....|....*....|....*....|....*..
gi 499658306 725 EGVERASQREALLGMGCHGFQGYLLGRPMDPLRLAAL 761
Cdd:COG5001 636 EGVETEEQLEFLRELGCDYAQGYLFSRPLPAEELEAL 672
|
|
| EAL |
COG2200 |
EAL domain, c-di-GMP-specific phosphodiesterase class I (or its enzymatically inactive variant) ... |
229-761 |
1.90e-92 |
|
EAL domain, c-di-GMP-specific phosphodiesterase class I (or its enzymatically inactive variant) [Signal transduction mechanisms];
Pssm-ID: 441802 [Multi-domain] Cd Length: 576 Bit Score: 300.55 E-value: 1.90e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 229 AVVQAAGTEYLHVAVQMADADMAARLSNTYEFDRGSFSVQPGPEDRLSVPLRDGAGRPIAWFVWRADRPGHRIVDEMLPV 308
Cdd:COG2200 38 ASALLLAVAALLAALLAALLLLLALALLLLLLLLLLLLLLLLLLLLALLLLLLLLLLLLLLLLLLLALLLAALLALLLLL 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 309 VGLFAAFGAALLTWLLRTLWTASRRLHQSEEEARYLAMHDPLAGIPNRTLFEDRLDQALKAERRGGPPVALLCLDLDRFK 388
Cdd:COG2200 118 LLLLLLLLLSLLLLLVLVLLRLALELLLALLLLALLALLDLLLLLLLRRLLLLLLLLLLLLLLALALLALLLLLLLLLLL 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 389 AVNDTMGHQAGDELIRQMAARLRSHVRETDTVARLGGDEFGVILIGMASDETLGRYCSGLVHLLAAPCDLKCGQVQIGAS 468
Cdd:COG2200 198 LLDNDGLGGAGLLLLLLLALLLLLLLARLLLALLGGGGGGFLLLLLLLAAAAAAAAALRLLLLLLLEPLLLGGGLVVVAS 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 469 IGAVRAASVDGGREAILRSADTALYRAKAEGRGRYCIATPEMNDIFRRRHEIERDLREAVAEGgQIHVLYQPIFDAEE-R 547
Cdd:COG2200 278 SGGGAAAPDDGADAALLLAAAAAAAAAAAGGGRGRVVFFAAAEARARRRLALESELREALEEG-ELRLYYQPIVDLRTgR 356
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 548 IVAAEALVRWNHPILGQMGPETFLSIAEETGLIDRIGHHVLEQAC----ILAATSGIPRVSVNISPVQLRQETFADEVLA 623
Cdd:COG2200 357 VVGYEALLRWRHPDGGLISPAEFIPAAERSGLIVELDRWVLERALrqlaRWPERGLDLRLSVNLSARSLLDPDFLERLLE 436
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 624 VMAAHSLSGERLVLELTEKFTLDAGPATLANLARLRAAGVSIALDDFATGQSLLRYVRDYQIDTIKIDRSYVARLGTGDG 703
Cdd:COG2200 437 LLAEYGLPPERLVLEITESALLEDLEAAIELLARLRALGVRIALDDFGTGYSSLSYLKRLPPDYLKIDRSFVRDIARDPR 516
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*...
gi 499658306 704 TDQIVRAILDLGRAMGIEVTAEGVERASQREALLGMGCHGFQGYLLGRPMDPLRLAAL 761
Cdd:COG2200 517 DQAIVRAIVALAHRLGLKVVAEGVETEEQLEALRELGCDYAQGYLFGRPLPLEELEAL 574
|
|
| EAL |
cd01948 |
EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL ... |
522-755 |
4.24e-89 |
|
EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second messenger, cyclic di-GMP, and is a good candidate for a diguanylate phosphodiesterase function. Together with the GGDEF domain, EAL might be involved in regulating cell surface adhesiveness in bacteria.
Pssm-ID: 238923 [Multi-domain] Cd Length: 240 Bit Score: 280.20 E-value: 4.24e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 522 RDLREAVAEGgQIHVLYQPIFDAEE-RIVAAEALVRWNHPILGQMGPETFLSIAEETGLIDRIGHHVLEQACILAAT--- 597
Cdd:cd01948 1 ADLRRALERG-EFELYYQPIVDLRTgRIVGYEALLRWRHPEGGLISPAEFIPLAEETGLIVELGRWVLEEACRQLARwqa 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 598 -SGIPRVSVNISPVQLRQETFADEVLAVMAAHSLSGERLVLELTEKFTLDAGPATLANLARLRAAGVSIALDDFATGQSL 676
Cdd:cd01948 80 gGPDLRLSVNLSARQLRDPDFLDRLLELLAETGLPPRRLVLEITESALIDDLEEALATLRRLRALGVRIALDDFGTGYSS 159
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 499658306 677 LRYVRDYQIDTIKIDRSYVARLGTGDGTDQIVRAILDLGRAMGIEVTAEGVERASQREALLGMGCHGFQGYLLGRPMDP 755
Cdd:cd01948 160 LSYLKRLPVDYLKIDRSFVRDIETDPEDRAIVRAIIALAHSLGLKVVAEGVETEEQLELLRELGCDYVQGYLFSRPLPA 238
|
|
| EAL |
smart00052 |
Putative diguanylate phosphodiesterase; Putative diguanylate phosphodiesterase, present in a ... |
521-753 |
3.73e-80 |
|
Putative diguanylate phosphodiesterase; Putative diguanylate phosphodiesterase, present in a variety of bacteria.
Pssm-ID: 214491 [Multi-domain] Cd Length: 242 Bit Score: 256.76 E-value: 3.73e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 521 ERDLREAVAEGgQIHVLYQPIFDAEE-RIVAAEALVRWNHPILGQMGPETFLSIAEETGLIDRIGHHVLEQAC-----IL 594
Cdd:smart00052 1 ERELRQALENG-QFLLYYQPIVSLRTgRLVGVEALIRWQHPEGGIISPDEFIPLAEETGLIVPLGRWVLEQACqqlaeWQ 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 595 AATSGIPRVSVNISPVQLRQETFADEVLAVMAAHSLSGERLVLELTEKFTLDAGPATLANLARLRAAGVSIALDDFATGQ 674
Cdd:smart00052 80 AQGPPPLLISINLSARQLISPDLVPRVLELLEETGLPPQRLELEITESVLLDDDESAVATLQRLRELGVRIALDDFGTGY 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 675 SLLRYVRDYQIDTIKIDRSYVARLGTgDGTDQ-IVRAILDLGRAMGIEVTAEGVERASQREALLGMGCHGFQGYLLGRPM 753
Cdd:smart00052 160 SSLSYLKRLPVDLLKIDKSFVRDLQT-DPEDEaIVQSIIELAQKLGLQVVAEGVETPEQLDLLRSLGCDYGQGYLFSRPL 238
|
|
| PRK10060 |
PRK10060 |
cyclic di-GMP phosphodiesterase; |
337-753 |
1.11e-79 |
|
cyclic di-GMP phosphodiesterase;
Pssm-ID: 236645 [Multi-domain] Cd Length: 663 Bit Score: 268.86 E-value: 1.11e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 337 SEEEARYLAMHDPLAGIPNRTLFEDRLDQALkaERRGGPPVALLCLDLDRFKAVNDTMGHQAGDELIRQMAARLRSHVRE 416
Cdd:PRK10060 229 AQERLRILANTDSITGLPNRNAIQELIDHAI--NAADNNQVGIVYLDLDNFKKVNDAYGHMFGDQLLQDVSLAILSCLEE 306
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 417 TDTVARLGGDEFgVILIGMASDETLGRYCSGLVHLLAAPCDLKCGQVQIGASIGAVRAASVDGGREAILRSADTALYRAK 496
Cdd:PRK10060 307 DQTLARLGGDEF-LVLASHTSQAALEAMASRILTRLRLPFRIGLIEVYTGCSIGIALAPEHGDDSESLIRSADTAMYTAK 385
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 497 AEGRGRYCIATPEMNDIFRRRHEIERDLREAVaEGGQIHVLYQPIFDAEERIVAAEALVRWNHPILGQMGPETFLSIAEE 576
Cdd:PRK10060 386 EGGRGQFCVFSPEMNQRVFEYLWLDTNLRKAL-ENDQLVIHYQPKITWRGEVRSLEALVRWQSPERGLIPPLEFISYAEE 464
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 577 TGLIDRIGHHVLEQACILAA---TSGIP-RVSVNISPVQLRQETFADEVLAVMAAHSLSGERLVLELTEKFTLDAGPATL 652
Cdd:PRK10060 465 SGLIVPLGRWVMLDVVRQVAkwrDKGINlRVAVNVSARQLADQTIFTALKQALQELNFEYCPIDVELTESCLIENEELAL 544
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 653 ANLARLRAAGVSIALDDFATGQSLLRYVRDYQIDTIKIDRSYVARLGTGDGTDQIVRAILDLGRAMGIEVTAEGVERASQ 732
Cdd:PRK10060 545 SVIQQFSQLGAQVHLDDFGTGYSSLSQLARFPIDAIKLDQSFVRDIHKQPVSQSLVRAIVAVAQALNLQVIAEGVETAKE 624
|
410 420
....*....|....*....|.
gi 499658306 733 REALLGMGCHGFQGYLLGRPM 753
Cdd:PRK10060 625 DAFLTKNGVNERQGFLFAKPM 645
|
|
| PRK11359 |
PRK11359 |
cyclic-di-GMP phosphodiesterase; Provisional |
338-755 |
1.85e-73 |
|
cyclic-di-GMP phosphodiesterase; Provisional
Pssm-ID: 183097 [Multi-domain] Cd Length: 799 Bit Score: 255.08 E-value: 1.85e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 338 EEEAR----YLAMHDPLAGIPNRTLFEDRLDQALKAErrggPPVALLCLDLDRFKAVNDTMGHQAGDELIRQMAARLRSH 413
Cdd:PRK11359 365 QEKSRqhieQLIQFDPLTGLPNRNNLHNYLDDLVDKA----VSPVVYLIGVDHFQDVIDSLGYAWADQALLEVVNRFREK 440
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 414 VRETDTVARLGGDEFgvILIGMASD-ETLGRYCSGLVHLLAAPCDLKCGQVQIGASIGAvrAASVDGGREAILRSADTAL 492
Cdd:PRK11359 441 LKPDQYLCRIEGTQF--VLVSLENDvSNITQIADELRNVVSKPIMIDDKPFPLTLSIGI--SYDVGKNRDYLLSTAHNAM 516
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 493 YRAKAEGRGRYCIATPEMNDIFRRRHEIERDLREAVAEGgQIHVLYQP-IFDAEERIVAAEALVRWNHPILGQMGPETFL 571
Cdd:PRK11359 517 DYIRKNGGNGWQFFSPAMNEMVKERLVLGAALKEAISNN-QLKLVYQPqIFAETGELYGIEALARWHDPLHGHVPPSRFI 595
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 572 SIAEETGLIDRIGHHVLEQAC-----ILAATSGIPRVSVNISPVQLRQETFADEVLAVMAAHSLSGERLVLELTEKFTLD 646
Cdd:PRK11359 596 PLAEEIGEIENIGRWVIAEACrqlaeWRSQNIHIPALSVNLSALHFRSNQLPNQVSDAMQAWGIDGHQLTVEITESMMME 675
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 647 AGPATLANLARLRAAGVSIALDDFATGQSLLRYVRDYQIDTIKIDRSYVARLGTGDGTDQIVRAILDLGRAMGIEVTAEG 726
Cdd:PRK11359 676 HDTEIFKRIQILRDMGVGLSVDDFGTGFSGLSRLVSLPVTEIKIDKSFVDRCLTEKRILALLEAITSIGQSLNLTVVAEG 755
|
410 420
....*....|....*....|....*....
gi 499658306 727 VERASQREALLGMGCHGFQGYLLGRPMDP 755
Cdd:PRK11359 756 VETKEQFEMLRKIHCRVIQGYFFSRPLPA 784
|
|
| EAL |
pfam00563 |
EAL domain; This domain is found in diverse bacterial signaling proteins. It is called EAL ... |
521-752 |
7.06e-65 |
|
EAL domain; This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues. The EAL domain is a good candidate for a diguanylate phosphodiesterase function. The domain contains many conserved acidic residues that could participate in metal binding and might form the phosphodiesterase active site.
Pssm-ID: 425752 [Multi-domain] Cd Length: 235 Bit Score: 215.64 E-value: 7.06e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 521 ERDLREAVaEGGQIHVLYQPIFDAEE-RIVAAEALVRWNHPILGQMGPETFLSIAEETGLIDRIGHHVLEQAC-ILAATS 598
Cdd:pfam00563 1 ARALRRAL-ENGEFVLYYQPIVDLRTgRVVGYEALLRWQHPDGGLISPARFLPLAEELGLIAELDRWVLEQALaDLAQLQ 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 599 GIP--RVSVNISPVQLRQETFADEVLAVMAAHSLSGERLVLELTEKFTLDAGPATLANLARLRAAGVSIALDDFATGQSL 676
Cdd:pfam00563 80 LGPdiKLSINLSPASLADPGFLELLRALLKQAGPPPSRLVLEITESDLLARLEALREVLKRLRALGIRIALDDFGTGYSS 159
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 499658306 677 LRYVRDYQIDTIKIDRSYVARLGTGDGTDQIVRAILDLGRAMGIEVTAEGVERASQREALLGMGCHGFQGYLLGRP 752
Cdd:pfam00563 160 LSYLLRLPPDFVKIDRSLIADIDKDGEARAIVRALIALAHSLGIKVVAEGVETEEQLEALRELGCDLVQGYYFSKP 235
|
|
| YjcC |
COG4943 |
Redox-sensing c-di-GMP phosphodiesterase, contains CSS-motif and EAL domains [Signal ... |
513-755 |
5.99e-61 |
|
Redox-sensing c-di-GMP phosphodiesterase, contains CSS-motif and EAL domains [Signal transduction mechanisms];
Pssm-ID: 443970 [Multi-domain] Cd Length: 528 Bit Score: 214.39 E-value: 5.99e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 513 IFRRRHEIERDLREAVAEGgQIHVLYQPIFDAE-ERIVAAEALVRWNHPILGQMGPETFLSIAEETGLIDRIGHHVLEQA 591
Cdd:COG4943 265 LLRRRLSPRRRLRRAIKRR-EFYVHYQPIVDLKtGRCVGAEALVRWRDPDGSVISPDIFIPLAEQSGLISPLTRQVIEQV 343
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 592 C-----ILAATSGIpRVSVNISPVQLRQETFADEVLAVMAAHSLSGERLVLELTEKFTLDaGPATLANLARLRAAGVSIA 666
Cdd:COG4943 344 FrdlgdLLAADPDF-HISINLSASDLLSPRFLDDLERLLARTGVAPQQIVLEITERGFID-PAKARAVIAALREAGHRIA 421
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 667 LDDFATGQSLLRYVRDYQIDTIKIDRSYVARLGTGDGTDQIVRAILDLGRAMGIEVTAEGVERASQREALLGMGCHGFQG 746
Cdd:COG4943 422 IDDFGTGYSSLSYLQTLPVDILKIDKSFVDAIGTDSANSAVVPHIIEMAKTLNLDVVAEGVETEEQADYLRARGVQYGQG 501
|
....*....
gi 499658306 747 YLLGRPMDP 755
Cdd:COG4943 502 WLFAKPLPA 510
|
|
| PRK09776 |
PRK09776 |
putative diguanylate cyclase; Provisional |
343-753 |
6.14e-61 |
|
putative diguanylate cyclase; Provisional
Pssm-ID: 182070 [Multi-domain] Cd Length: 1092 Bit Score: 223.01 E-value: 6.14e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 343 YLAMHDPLAGIPNRTLFEDRLDQALKAERRGGPPVALLCLDLDRFKAVNDTMGHQAGDELIRQMAARLRSHVRETDTVAR 422
Cdd:PRK09776 663 YSASHDALTHLANRASFEKQLRRLLQTVNSTHQRHALVFIDLDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLAR 742
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 423 LGGDEFGVIL--IGMASDETLgryCSGLVHLLAAPCDLKCGQV-QIGASIGAVRAASVDGGREAILRSADTALYRAKAEG 499
Cdd:PRK09776 743 LGGDEFGLLLpdCNVESARFI---ATRIISAINDYHFPWEGRVyRVGASAGITLIDANNHQASEVMSQADIACYAAKNAG 819
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 500 RGRYCIATPEMNDIFRRRHEIERDLREAVAEGGQIHVLYQPIFDA--EERIVAAEALVRWNHPiLGQMGPE-TFLSIAEE 576
Cdd:PRK09776 820 RGRVTVYEPQQAAAHSEHRALSLAEQWRMIKENQLMMLAHGVASPriPEARNHWLISLRLWDP-EGEIIDEgAFRPAAED 898
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 577 TGLI----DRIGHHVLEQACILAATSGIPrVSVNISPVQLRQETFADEVLAVMAAHSLSGERLVLELTEKFTLDAGPATL 652
Cdd:PRK09776 899 PALMhaldRRVIHEFFRQAAKAVASKGLS-IALPLSVAGLSSPTLLPFLLEQLENSPLPPRLLHLEITETALLNHAESAS 977
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 653 ANLARLRAAGVSIALDDFATGQSLLRYVRDYQIDTIKIDRSYVARLGTGDGTDQIVRAILDLGRAMGIEVTAEGVERASQ 732
Cdd:PRK09776 978 RLVQKLRLAGCRVVLSDFGRGLSSFNYLKAFMADYLKLDGELVANLHGNLMDEMLISIIQGHAQRLGMKTIAGPVELPLV 1057
|
410 420
....*....|....*....|.
gi 499658306 733 REALLGMGCHGFQGYLLGRPM 753
Cdd:PRK09776 1058 LDTLSGIGVDLAYGYAIARPQ 1078
|
|
| PRK13561 |
PRK13561 |
putative diguanylate cyclase; Provisional |
333-755 |
3.96e-56 |
|
putative diguanylate cyclase; Provisional
Pssm-ID: 184143 [Multi-domain] Cd Length: 651 Bit Score: 203.79 E-value: 3.96e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 333 RLHQSEEEARYLAMHDPLAGIPNRTLFEDRLDQALkaerRGGPPVALLCLDLDRFKAVNDTMGHQAGDELIRQMAARLRS 412
Cdd:PRK13561 219 LLQRQYEEQSRNATRFPVSDLPNKALLMALLEQVV----ARKQTTALMIITCETLRDTAGVLKEAQREILLLTLVEKLKS 294
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 413 HVRETDTVARLGGDEFGVILIGMASDE---TLGRycsGLVHLLAAPCDLKCGQVQIGASIG-AVRAAsvDGGREAILRSA 488
Cdd:PRK13561 295 VLSPRMVLAQISGYDFAIIANGVKEPWhaiTLGQ---QVLTIINERLPIQRIQLRPSCSIGiAMFYG--DLTAEQLYSRA 369
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 489 DTALYRAKAEGRGRYCIATPEMNDIFRRRHEIERDLREAVAEGgQIHVLYQPIFDAEE-RIVAAEALVRWNHPILGQMGP 567
Cdd:PRK13561 370 ISAAFTARRKGKNQIQFFDPQQMEAAQKRLTEESDILNALENH-QFAIWLQPQVEMRSgKLVSAEALLRMQQPDGSWDLP 448
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 568 ETFLSIAEETGLIDRIGHHVLEQAC-ILAA--TSGI--PrVSVNISPVQLRQETFADEVLAVMAAHSLSGERLVLELTEK 642
Cdd:PRK13561 449 EGLIDRIESCGLMVTVGHWVLEESCrLLAAwqERGImlP-LSVNLSALQLMHPNMVADMLELLTRYRIQPGTLILEVTES 527
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 643 FTLDAGPATLANLARLRAAGVSIALDDFATGQSLLRYVRDYQ---IDTIKIDRSYVARLGTgdgTDQIVRAILDLGRAMG 719
Cdd:PRK13561 528 RRIDDPHAAVAILRPLRNAGVRVALDDFGMGYAGLRQLQHMKslpIDVLKIDKMFVDGLPE---DDSMVAAIIMLAQSLN 604
|
410 420 430
....*....|....*....|....*....|....*.
gi 499658306 720 IEVTAEGVERASQREALLGMGCHGFQGYLLGRPMDP 755
Cdd:PRK13561 605 LQVIAEGVETEAQRDWLLKAGVGIAQGFLFARALPI 640
|
|
| GGDEF |
cd01949 |
Diguanylate-cyclase (DGC) or GGDEF domain; Diguanylate-cyclase (DGC) or GGDEF domain: ... |
346-504 |
8.88e-54 |
|
Diguanylate-cyclase (DGC) or GGDEF domain; Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.
Pssm-ID: 143635 [Multi-domain] Cd Length: 158 Bit Score: 182.76 E-value: 8.88e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 346 MHDPLAGIPNRTLFEDRLDQALKAERRGGPPVALLCLDLDRFKAVNDTMGHQAGDELIRQMAARLRSHVRETDTVARLGG 425
Cdd:cd01949 1 YTDPLTGLPNRRAFEERLERLLARARRSGRPLALLLIDIDHFKQINDTYGHAAGDEVLKEVAERLRSSLRESDLVARLGG 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 499658306 426 DEFGVILIGMASDETLgRYCSGLVHLLAAPCDLKCGQVQIGASIGAVRAASVDGGREAILRSADTALYRAKAEGRGRYC 504
Cdd:cd01949 81 DEFAILLPGTDLEEAE-ALAERLREAIEEPFFIDGQEIRVTASIGIATYPEDGEDAEELLRRADEALYRAKRSGRNRVV 158
|
|
| GGDEF |
COG2199 |
GGDEF domain, diguanylate cyclase (c-di-GMP synthetase) or its enzymatically inactive variants ... |
239-506 |
3.34e-53 |
|
GGDEF domain, diguanylate cyclase (c-di-GMP synthetase) or its enzymatically inactive variants [Signal transduction mechanisms];
Pssm-ID: 441801 [Multi-domain] Cd Length: 275 Bit Score: 185.57 E-value: 3.34e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 239 LHVAVQMADADMAARLSNTYEFDRGSFSVQPGPEDRLSVPLRDGAGRPIAWFVWRADRPGHRIVDEMLPVVGLFAAFGAA 318
Cdd:COG2199 8 LLALLLLLLLLLLSLLLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLVLLLLALGLLLLALLLLSLVLELLLLL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 319 LLTWLLRTLWTASRRLHQSEEEARYLAMHDPLAGIPNRTLFEDRLDQALKAERRGGPPVALLCLDLDRFKAVNDTMGHQA 398
Cdd:COG2199 88 LALLLLLLALEDITELRRLEERLRRLATHDPLTGLPNRRAFEERLERELARARREGRPLALLLIDLDHFKRINDTYGHAA 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 399 GDELIRQMAARLRSHVRETDTVARLGGDEFGVILIGMASDETLgRYCSGLVHLLAA-PCDLKCGQVQIGASIGAVRAASV 477
Cdd:COG2199 168 GDEVLKEVARRLRASLRESDLVARLGGDEFAVLLPGTDLEEAE-ALAERLREALEQlPFELEGKELRVTVSIGVALYPED 246
|
250 260
....*....|....*....|....*....
gi 499658306 478 DGGREAILRSADTALYRAKAEGRGRYCIA 506
Cdd:COG2199 247 GDSAEELLRRADLALYRAKRAGRNRVVVY 275
|
|
| CHASE4 |
COG3322 |
Extracellular (periplasmic) sensor domain CHASE (specificity unknown) [Signal transduction ... |
53-768 |
3.97e-53 |
|
Extracellular (periplasmic) sensor domain CHASE (specificity unknown) [Signal transduction mechanisms];
Pssm-ID: 442551 [Multi-domain] Cd Length: 724 Bit Score: 196.70 E-value: 3.97e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 53 LVAAILFACLVATLSVLFLSStaVNAVDADAEARQIRFAQRALLRETRELLQQQQASTVWDESVVHVRAGDRDWIDSNLG 132
Cdd:COG3322 13 LLLLLLLALLYLVSRLILLSS--FSELEEQAAERDVERVLNALDAELDQLARLVADWAVWDDTYEFVQDGDPEWIESNLG 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 133 TWMHEEYGQDETYIVDPASRIVY-VARERVTGQPGPratLPPAVEEMVEEMRPMMRAATRnradstadvaDLSLSRFVLL 211
Cdd:COG3322 91 DWTFENLGLDLVLVLDPDGRLVYsKGYDLEDGELVP---LPEALAPLLARARALLRHASP----------DSSVSGLLRL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 212 GGKPALVSVVPIVPDTpavvQAAGTEYLHVAVQMADADMAARLSNTYEFDrgsFSVQPGPEDRL---------------S 276
Cdd:COG3322 158 DGGPALVAARPILPSD----GPGPPRGTLVFGRYLDEAFLARLAERTGLD---LTLSPADPPAPpdqvveplsddtiagY 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 277 VPLRDGAGRPIAWFVWRADRP----GHRIVDEMLPVVGLFAAFGAALLTWLLRTLWTASRRLHQSEEEARYLAMHDPLAG 352
Cdd:COG3322 231 VPLRDIDGQPVLLLRWTPPRPiyqqGRALLRYLLPALLLLGLLLALLALLLLRLVLLLLLLLLRLVLSRLLLLLLRLLLL 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 353 IPNRTLFEDRLDQALKAERRGGPPVALLCLDLDRFKAVNDTMGHQAGDELIRQMAARLRSHVRETDTVARLGGDEFGVIL 432
Cdd:COG3322 311 ELLRALELLLLLLRRLLLLLLLLRLLLLLLDLLAALNLLLLLRALAERLVALALLALLLLGLLGLLAALRRLGLLAILAL 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 433 IGMASDETLGRYCSGLVHLLAAPCDLkcgqvqigasiGAVRAASVDGGREAILRSADTALYRAKAEGRGRYCIATPEMND 512
Cdd:COG3322 391 AEEAARLLLLALAIAGELLIGIEVLL-----------ALGLELAGSAIALARAAAALALLLAAAAAARLAARAASGLLRD 459
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 513 IFRRRHEIERDLREAVAEGGQIHVLYQPIFDAEERIVAAEALVRWNHPILGQMGPETFLSIAEETGLIDRIGHHVLEQAC 592
Cdd:COG3322 460 LLEADELEDRLRRALLAEAAALLLLALLALELLLALGDAALEILLAILLLGLVLEAQLAELERLLLLGEAGGELLEEIAL 539
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 593 ILAATSGIPRVSVNISPVQLRQETFADEVLAVMAAHSLSGERLVLELTEKFTLDAGPATLANLARLRAAGVSIALDDFAT 672
Cdd:COG3322 540 LAALLAGLLLAVLLSLLLRLLLLIDALVALAEAAAGLLEALLEEEVELRRALLEAEELLLIALALLSLGLALALDDGGRG 619
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 673 GQSLLRYVRDYQIDTIKIDRSYVARLGTGDGTDQIVRAILDLGRAMGIEVTAEGVERASQREALLGMGCHGFQGYLLGRP 752
Cdd:COG3322 620 LAGLLLLFRLSGIGLLLLRRLLGDDLLGLLAALIDLILALAGSLLLLTLAAAAEATAVVLVAELLEGALLLQALALISLL 699
|
730
....*....|....*.
gi 499658306 753 MDPLRLAALSARKGVA 768
Cdd:COG3322 700 ELLLLLLLLELQLLEQ 715
|
|
| PRK11829 |
PRK11829 |
biofilm formation regulator HmsP; Provisional |
349-753 |
9.19e-47 |
|
biofilm formation regulator HmsP; Provisional
Pssm-ID: 183329 [Multi-domain] Cd Length: 660 Bit Score: 177.06 E-value: 9.19e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 349 PLAGIPNRTLFEDRLDQ--ALKAERRGgppVALLCLDLDRFKAVNDTMGHQAGDELIRQMAARLRSHVRETDTVARLGGD 426
Cdd:PRK11829 236 PVTELPNRSLFISLLEKeiASSTRTDH---FHLLVIGIETLQEVSGAMSEAQHQQLLLTIVQRIEQCIDDSDLLAQLSKT 312
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 427 EFGVILIGMASDETLGRYCSGLVHLLAAPCDLKCGQVQIGASIGAVRAASVDGGREAILRSADTALYRAKAEGRGRYCIA 506
Cdd:PRK11829 313 EFAVLARGTRRSFPAMQLARRIMSQVTQPLFFDEITLRPSASIGITRYQAQQDTAESMMRNASTAMMAAHHEGRNQIMVF 392
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 507 TPEMNDIFRRRHEIERDLREAVaEGGQIHVLYQPIFDAE-ERIVAAEALVRWNHPILGQMGPETFLSIAEETGLIDRIGH 585
Cdd:PRK11829 393 EPHLIEKTHKRLTQENDLLQAI-ENHDFTLFLQPQWDMKrQQVIGAEALLRWCQPDGSYVLPSGFVHFAEEEGMMVPLGN 471
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 586 HVLEQAC-ILAATSG----IPrVSVNISPVQLRQETFADEVLAVMAAHSLSGERLVLELTEKFTLDAGPATLANLARLRA 660
Cdd:PRK11829 472 WVLEEACrILADWKArgvsLP-LSVNISGLQVQNKQFLPHLKTLISHYHIDPQQLLLEITETAQIQDLDEALRLLRELQG 550
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 661 AGVSIALDDFATGQSLLRYVRDYQ---IDTIKIDRSYVARLGTGDGTDQIVRAILDLgraMGIEVTAEGVERASQREALL 737
Cdd:PRK11829 551 LGLLIALDDFGIGYSSLRYLNHLKslpIHMIKLDKSFVKNLPEDDAIARIISCVSDV---LKVRVMAEGVETEEQRQWLL 627
|
410
....*....|....*.
gi 499658306 738 GMGCHGFQGYLLGRPM 753
Cdd:PRK11829 628 EHGIQCGQGFLFSPPL 643
|
|
| GGDEF |
smart00267 |
diguanylate cyclase; Diguanylate cyclase, present in a variety of bacteria. |
343-506 |
1.68e-46 |
|
diguanylate cyclase; Diguanylate cyclase, present in a variety of bacteria.
Pssm-ID: 128563 [Multi-domain] Cd Length: 163 Bit Score: 162.80 E-value: 1.68e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 343 YLAMHDPLAGIPNRTLFEDRLDQALKAERRGGPPVALLCLDLDRFKAVNDTMGHQAGDELIRQMAARLRSHVRETDTVAR 422
Cdd:smart00267 1 RLAFRDPLTGLPNRRYFEEELEQELQRAQRQGSPFALLLIDLDNFKDINDTYGHAVGDELLQEVAQRLSSCLRPGDLLAR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 423 LGGDEFGVILIGmASDETLGRYCSGLVHLLAAPCDLKCGQVQIGASIGAVRAASVDGGREAILRSADTALYRAKAEGRGR 502
Cdd:smart00267 81 LGGDEFALLLPE-TSLEEAIALAERILQQLREPIIIHGIPLYLTISIGVAAYPNPGEDAEDLLKRADTALYQAKKAGRNQ 159
|
....
gi 499658306 503 YCIA 506
Cdd:smart00267 160 VAVY 163
|
|
| GGDEF |
pfam00990 |
Diguanylate cyclase, GGDEF domain; This domain is found linked to a wide range of ... |
345-502 |
1.63e-45 |
|
Diguanylate cyclase, GGDEF domain; This domain is found linked to a wide range of non-homologous domains in a variety of bacteria. It has been shown to be homologous to the adenylyl cyclase catalytic domain and has diguanylate cyclase activity. This observation correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. In the WspR protein of Pseudomonas aeruginosa, the GGDEF domain acts as a diguanylate cyclase, PDB:3bre, when the whole molecule appears to form a tetramer consisting of two symmetrically-related dimers representing a biological unit. The active site is the GGD/EF motif, buried in the structure, and the cyclic dimeric guanosine monophosphate (c-di-GMP) bind to the inhibitory-motif RxxD on the surface. The enzyme thus catalyzes the cyclization of two guanosine triphosphate (GTP) molecules to one c-di-GMP molecule.
Pssm-ID: 425976 [Multi-domain] Cd Length: 160 Bit Score: 160.11 E-value: 1.63e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 345 AMHDPLAGIPNRTLFEDRLDQALKAERRGGPPVALLCLDLDRFKAVNDTMGHQAGDELIRQMAARLRSHVRETDTVARLG 424
Cdd:pfam00990 1 AAHDPLTGLPNRRYFEEQLEQELQRALREGSPVAVLLIDLDNFKRINDTYGHSVGDEVLQEVAQRLSSSLRRSDLVARLG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 425 GDEFGVIL--IGMASDETLGRYCSGLVHLLAAPCDLKCGQVQIGASIGAvrAASVDGGR--EAILRSADTALYRAKAEGR 500
Cdd:pfam00990 81 GDEFAILLpeTSLEGAQELAERIRRLLAKLKIPHTVSGLPLYVTISIGI--AAYPNDGEdpEDLLKRADTALYQAKQAGR 158
|
..
gi 499658306 501 GR 502
Cdd:pfam00990 159 NR 160
|
|
| PRK10551 |
PRK10551 |
cyclic di-GMP phosphodiesterase; |
532-760 |
1.72e-39 |
|
cyclic di-GMP phosphodiesterase;
Pssm-ID: 182541 [Multi-domain] Cd Length: 518 Bit Score: 153.22 E-value: 1.72e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 532 GQIHVLYQPIFDAEE-RIVAAEALVRWNHPILGQMGPETFLSIAEETGLIDRIGHHVLE----QACILAATsgIPR---V 603
Cdd:PRK10551 275 GQFYVEYQPVVDTQTlRVTGLEALLRWRHPTAGEIPPDAFINYAEAQKLIVPLTQHLFEliarDAAELQKV--LPVgakL 352
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 604 SVNISPVQLRQETFADEV---LAVMAAHSLSgerLVLELTEKFTLDAGPAtLANLARLRAAGVSIALDDFATGQSLLRYV 680
Cdd:PRK10551 353 GINISPAHLHSDSFKADVqrlLASLPADHFQ---IVLEITERDMVQEEEA-TKLFAWLHSQGIEIAIDDFGTGHSALIYL 428
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 681 RDYQIDTIKIDRSYVARLGTGDGTDQIVRAILDLGRAMGIEVTAEGVERASQREALLGMGCHGFQGYLLGRPMDPLRLAA 760
Cdd:PRK10551 429 ERFTLDYLKIDRGFIQAIGTETVTSPVLDAVLTLAKRLNMLTVAEGVETPEQARWLRERGVNFLQGYWISRPLPLEDFVR 508
|
|
| GGDEF |
TIGR00254 |
diguanylate cyclase (GGDEF) domain; The GGDEF domain is named for the motif GG[DE]EF shared by ... |
344-503 |
1.76e-39 |
|
diguanylate cyclase (GGDEF) domain; The GGDEF domain is named for the motif GG[DE]EF shared by many proteins carrying the domain. There is evidence that the domain has diguanylate cyclase activity. Several proteins carrying this domain also carry domains with functions relating to environmental sensing. These include PleD, a response regulator protein involved in the swarmer-to-stalked cell transition in Caulobacter crescentus, and FixL, a heme-containing oxygen sensor protein. [Regulatory functions, Small molecule interactions, Signal transduction, Other]
Pssm-ID: 272984 [Multi-domain] Cd Length: 165 Bit Score: 143.25 E-value: 1.76e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 344 LAMHDPLAGIPNRTLFEDRLDQALKAERRGGPPVALLCLDLDRFKAVNDTMGHQAGDELIRQMAARLRSHVRETDTVARL 423
Cdd:TIGR00254 1 QAVRDPLTGLYNRRYLEEMLDSELKRARRFQRSFSVLMIDIDNFKKINDTLGHDVGDEVLREVARILQSSVRGSDVVGRY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 424 GGDEFGVILIGMASDETLGRYCSGLVHLLAAPCDLKCG-QVQIGASIGAvrAASVDGGR--EAILRSADTALYRAKAEGR 500
Cdd:TIGR00254 81 GGEEFVVILPGTPLEDALSKAERLRDAINSKPIEVAGSeTLTVTVSIGV--ACYPGHGLtlEELLKRADEALYQAKKAGR 158
|
...
gi 499658306 501 GRY 503
Cdd:TIGR00254 159 NRV 161
|
|
| PRK09894 |
PRK09894 |
diguanylate cyclase; Provisional |
348-515 |
2.08e-28 |
|
diguanylate cyclase; Provisional
Pssm-ID: 182133 [Multi-domain] Cd Length: 296 Bit Score: 115.93 E-value: 2.08e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 348 DPLAGIPNRTLFEDRLDQALKaeRRGGPPVALLCLDLDRFKAVNDTMGHQAGDELIRQMAARLRSHVRETDTVARLGGDE 427
Cdd:PRK09894 132 DVLTGLPGRRVLDESFDHQLR--NREPQNLYLALLDIDRFKLVNDTYGHLIGDVVLRTLATYLASWTRDYETVYRYGGEE 209
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 428 FgVILIGMASDETLGRYCSGLVHLLAA-PCDLKCGQVQIGASIGAVRAASVDGGREAILRsADTALYRAKAEGRGRyCIA 506
Cdd:PRK09894 210 F-IICLKAATDEEACRAGERIRQLIANhAITHSDGRINITATFGVSRAFPEETLDVVIGR-ADRAMYEGKQTGRNR-VMF 286
|
....*....
gi 499658306 507 TPEMNDIFR 515
Cdd:PRK09894 287 IDEQNVINR 295
|
|
| pleD |
PRK09581 |
response regulator PleD; Reviewed |
344-506 |
1.41e-27 |
|
response regulator PleD; Reviewed
Pssm-ID: 236577 [Multi-domain] Cd Length: 457 Bit Score: 116.92 E-value: 1.41e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 344 LAMHDPLAGIPNRTLFEDRLDQALKAERRGGPPVALLCLDLDRFKAVNDTMGHQAGDELIRQMAARLRSHVRETDTVARL 423
Cdd:PRK09581 291 MAVTDGLTGLHNRRYFDMHLKNLIERANERGKPLSLMMIDIDHFKKVNDTYGHDAGDEVLREFAKRLRNNIRGTDLIARY 370
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 424 GGDEFGVIL--IGMASDETLGRYCsgLVHLLAAPCDLKCGQVQIG--ASIGAVRAASVDGGREAILRSADTALYRAKAEG 499
Cdd:PRK09581 371 GGEEFVVVMpdTDIEDAIAVAERI--RRKIAEEPFIISDGKERLNvtVSIGVAELRPSGDTIEALIKRADKALYEAKNTG 448
|
....*..
gi 499658306 500 RGRYCIA 506
Cdd:PRK09581 449 RNRVVAL 455
|
|
| PRK15426 |
PRK15426 |
cellulose biosynthesis regulator YedQ; |
342-504 |
2.27e-26 |
|
cellulose biosynthesis regulator YedQ;
Pssm-ID: 237964 [Multi-domain] Cd Length: 570 Bit Score: 114.34 E-value: 2.27e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 342 RYLAMHDPLAGIPNRTLFEDRLDQALKAERRGGPPVALLCLDLDRFKAVNDTMGHQAGDELIRQMAARLRSHVRETDTVA 421
Cdd:PRK15426 395 QWQAWHDPLTRLYNRGALFEKARALAKRCQRDQQPFSVIQLDLDHFKSINDRFGHQAGDRVLSHAAGLISSSLRAQDVAG 474
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 422 RLGGDEFGVILIGMASDETLGRYCSGLVHLLAAPCDLKCGQ-VQIGASIGAVRAA-SVDGGREAILRSADTALYRAKAEG 499
Cdd:PRK15426 475 RVGGEEFCVVLPGASLAEAAQVAERIRLRINEKEILVAKSTtIRISASLGVSSAEeDGDYDFEQLQSLADRRLYLAKQAG 554
|
....*
gi 499658306 500 RGRYC 504
Cdd:PRK15426 555 RNRVC 559
|
|
| CHASE4 |
pfam05228 |
CHASE4 domain; CHASE4. This is an extracellular sensory domain, which is present in various ... |
94-257 |
4.41e-23 |
|
CHASE4 domain; CHASE4. This is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are parts of signal transduction pathways in prokaryotes. Specifically, CHASE4 domains are found in histidine kinases in Archaea and in predicted diguanylate cyclases/phosphodiesterases in Bacteria. Environmental factors that are recognized by CHASE4 domains are not known at this time.
Pssm-ID: 428380 Cd Length: 139 Bit Score: 95.47 E-value: 4.41e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 94 ALLRETRELLQQQQASTVWDESVVHVRAGDRDWIDSNLGTWMHEEYGQDETYIVDPASRIVYVARERVTGQPGPRATLPp 173
Cdd:pfam05228 1 ALEQELDSLDRLLRDWAVWDDTYDFVQDGNPDYIESNLGPETFENLGLDLILFVDADGKLVYDLENGKPDSPLLSRSSP- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 174 aveemveemrpmmraatrnradstadvaDLSLSRFVLLGGKPALVSVVPIvPDTPAVVQAAGTeylHVAVQMADADMAAR 253
Cdd:pfam05228 80 ----------------------------DSGLSGIVLLGGGPALVAARPI-LTSDGSGPPRGT---LVMGRYLDEAFLDR 127
|
....
gi 499658306 254 LSNT 257
Cdd:pfam05228 128 LSEL 131
|
|
| adrA |
PRK10245 |
diguanylate cyclase AdrA; Provisional |
333-506 |
2.94e-21 |
|
diguanylate cyclase AdrA; Provisional
Pssm-ID: 182329 [Multi-domain] Cd Length: 366 Bit Score: 96.44 E-value: 2.94e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 333 RLHQSEEEARYLAMHDPLAGIPNRTLFEDRLDQALKAERRGGPPVALLCLDLDRFKAVNDTMGHQAGDELIRQMAARLRS 412
Cdd:PRK10245 193 KLAEHKRRLQVMSTRDGMTGVYNRRHWETLLRNEFDNCRRHHRDATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQI 272
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 413 HVRETDTVARLGGDEFGVILIGMASDE---TLGRYCSGLVHlLAAPCdlkCGQVQIGASIGAVRAASVDGGREAILRSAD 489
Cdd:PRK10245 273 TLRGSDVIGRFGGDEFAVIMSGTPAESaitAMSRVHEGLNT-LRLPN---APQVTLRISVGVAPLNPQMSHYREWLKSAD 348
|
170
....*....|....*..
gi 499658306 490 TALYRAKAEGRGRYCIA 506
Cdd:PRK10245 349 LALYKAKNAGRNRTEVA 365
|
|
| PRK09966 |
PRK09966 |
diguanylate cyclase DgcN; |
333-496 |
2.26e-19 |
|
diguanylate cyclase DgcN;
Pssm-ID: 182171 [Multi-domain] Cd Length: 407 Bit Score: 91.22 E-value: 2.26e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 333 RLHQSEEEARYLAMHDPLAGIPNRTLFEDRLDqALKAERRGGPPVALLCLDLDRFKAVNDTMGHQAGDELIRQMAARLRS 412
Cdd:PRK09966 236 RLQAKNAQLLRTALHDPLTGLANRAAFRSGIN-TLMNNSDARKTSALLFLDGDNFKYINDTWGHATGDRVLIEIAKRLAE 314
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 413 HVRETDTVARLGGDEFGVILIGMASDETLGRYCSGLVHLLAAPCDLKCGQ-----VQIGASIGAVRAASvdggrEAILRS 487
Cdd:PRK09966 315 FGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFDLHNGHqttmtLSIGYAMTIEHASA-----EKLQEL 389
|
....*....
gi 499658306 488 ADTALYRAK 496
Cdd:PRK09966 390 ADHNMYQAK 398
|
|
| YuxH |
COG3434 |
c-di-GMP phosphodiesterase YuxH/PdeH, contains EAL and HDOD domains [Signal transduction ... |
539-761 |
1.45e-18 |
|
c-di-GMP phosphodiesterase YuxH/PdeH, contains EAL and HDOD domains [Signal transduction mechanisms];
Pssm-ID: 442660 [Multi-domain] Cd Length: 407 Bit Score: 88.71 E-value: 1.45e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 539 QPIFDAEERIVAAEALVRwnhpilgqMGPETFLSIAEEtgliDRIGHHVLEQACilaATSGIPRVS------VNISPvql 612
Cdd:COG3434 9 QPILDRDQRVVGYELLFR--------SGLENSAPDVDG----DQATARVLLNAF---LEIGLDRLLggklafINFTE--- 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 613 rqetfadEVLAVMAAHSLSGERLVLELTEKFTLDagPATLANLARLRAAGVSIALDDF---ATGQSLLRYVrdyqiDTIK 689
Cdd:COG3434 71 -------ELLLSDLPELLPPERVVLEILEDVEPD--EELLEALKELKEKGYRIALDDFvldPEWDPLLPLA-----DIIK 136
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 499658306 690 IDrsyvARLGTGDGTDQIVRAIldlgRAMGIEVTAEGVERASQREALLGMGCHGFQGYLLGRP-------MDPLRLAAL 761
Cdd:COG3434 137 ID----VLALDLEELAELVARL----KRYGIKLLAEKVETREEFELCKELGFDLFQGYFFSKPeilkgkkLPPSQLTLL 207
|
|
| diguan_DgcJ |
NF040885 |
diguanylate cyclase DgcJ; |
348-433 |
1.40e-15 |
|
diguanylate cyclase DgcJ;
Pssm-ID: 468821 [Multi-domain] Cd Length: 490 Bit Score: 80.00 E-value: 1.40e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 348 DPLAGIPNRTLFEDRLDQALKAERRGGPPVALLCLDLDRFKAVNDTMGHQAGDELIRQMAARLRSHVRETDTVARLGGDE 427
Cdd:NF040885 344 DSMTGLYNRKILTPTLEQRLQRLTEKGIPVTFIALDCDKLKHINDTLGHHEGDRAITLLAQAISASIRKSDYGIRLGGDE 423
|
....*.
gi 499658306 428 FGVILI 433
Cdd:NF040885 424 FCIILI 429
|
|
| PRK11059 |
PRK11059 |
regulatory protein CsrD; Provisional |
342-746 |
4.57e-09 |
|
regulatory protein CsrD; Provisional
Pssm-ID: 236833 [Multi-domain] Cd Length: 640 Bit Score: 59.88 E-value: 4.57e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 342 RYLAMHDPLAGIPNRTLFEDRLDQALKAERRGGPPVALLCLDLDRFKAVNDTMGHQAGDELIRQMAARLRSHV-RETDTV 420
Cdd:PRK11059 225 RSNAFQDAKTGLGNRLFFDNQLATLLEDQEMVGAHGVVMLIRLPDFDLLQEEWGESQVEELLFELINLLSTFVmRYPGAL 304
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 421 -ARLGGDEFGVIL--IGMASDETLGrycSGLVHLLAA--PCDLKCGQ--VQIGASigavrAASVDGGREAILRSADTALY 493
Cdd:PRK11059 305 lARYSRSDFAVLLphRSLKEADSLA---SQLLKAVDAlpPPKMLDRDdfLHIGIC-----AYRSGQSTEQVMEEAEMALR 376
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 494 RAKAEGRGRYCiatpemndIFRRRHEIE--------RDLREAVAEGGQIHVLYQPIFDAEERIVAAEALVRWNHPILGQM 565
Cdd:PRK11059 377 SAQLQGGNGWF--------VYDKAQLPEkgrgsvrwRTLLEQTLVRGGPRLYQQPAVTRDGKVHHRELFCRIRDGQGELL 448
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 566 GPETFLSIAEETGLIDRIGHHVLEQACILAATSGIPRVSVNISPVQLRQETFA----DEVLAVMAAHSlsgERLVLELTE 641
Cdd:PRK11059 449 SAELFMPMVQQLGLSEQYDRQVIERVLPLLRYWPEENLSINLSVDSLLSRAFQrwlrDTLLQCPRSQR---KRLIFELAE 525
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 642 kftldagpATL-ANLARLRAA-------GVSIALDDfaTGQSLL--RYVRDYQIDTIKIDRSYVARLgtgdgtDQ----- 706
Cdd:PRK11059 526 --------ADVcQHISRLRPVlrmlrglGCRLAVDQ--AGLTVVstSYIKELNVELIKLHPSLVRNI------HKrtenq 589
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 499658306 707 -IVRAILDLGRAMGIEVTAEGVERASQREALLGMGCHGFQG 746
Cdd:PRK11059 590 lFVRSLVGACAGTETQVFATGVESREEWQTLQELGVSGGQG 630
|
|
| Nucleotidyl_cyc_III |
cd07556 |
Class III nucleotidyl cyclases; Class III nucleotidyl cyclases are the largest, most diverse ... |
376-432 |
1.61e-07 |
|
Class III nucleotidyl cyclases; Class III nucleotidyl cyclases are the largest, most diverse group of nucleotidyl cyclases (NC's) containing prokaryotic and eukaryotic proteins. They can be divided into two major groups; the mononucleotidyl cyclases (MNC's) and the diguanylate cyclases (DGC's). The MNC's, which include the adenylate cyclases (AC's) and the guanylate cyclases (GC's), have a conserved cyclase homology domain (CHD), while the DGC's have a conserved GGDEF domain, named after a conserved motif within this subgroup. Their products, cyclic guanylyl and adenylyl nucleotides, are second messengers that play important roles in eukaryotic signal transduction and prokaryotic sensory pathways.
Pssm-ID: 143637 [Multi-domain] Cd Length: 133 Bit Score: 50.82 E-value: 1.61e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 499658306 376 PVALLCLDLDRFKAVNDTMGHQAGDELIRQMAARLRSHVRET-DTVARLGGDEFGVIL 432
Cdd:cd07556 1 PVTILFADIVGFTSLADALGPDEGDELLNELAGRFDSLIRRSgDLKIKTIGDEFMVVS 58
|
|
| PksD |
COG3321 |
Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites ... |
257-764 |
6.44e-03 |
|
Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism];
Pssm-ID: 442550 [Multi-domain] Cd Length: 1386 Bit Score: 40.24 E-value: 6.44e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 257 TYEFDRGSFSVQPGPEDRLSVPLRDGAGRPIAWFVWRADRPGHRIVDEMLPVVGLFAAFGAALLTWLLRTLWTASRRLHQ 336
Cdd:COG3321 865 TYPFQREDAAAALLAAALAAALAAAAALGALLLAALAAALAAALLALAAAAAAALALAAAALAALLALVALAAAAAALLA 944
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 337 SEEEARYLAMHDPLAGIPNRTLFEDRLDQALKAERRGGPPVALLCLDLDRFKAVNDTMGHQAGDELIRQMAARLRSHVRE 416
Cdd:COG3321 945 LAAAAAAAAAALAAAEAGALLLLAAAAAAAAAAAAAAAAAAAAAAAAAAAALAAAAALALLAAAALLLAAAAAAAALLAL 1024
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 417 TDTVARLGGDEFGVILIGMASDETLGRYCSGLVHLLAAPCDLKcGQVQIGASIGAVRAASVDGGREAILRSADTALYRAK 496
Cdd:COG3321 1025 AALLAAAAAALAAAAAAAAAAAALAALAAAAAAAAALALALAA-LLLLAALAELALAAAALALAAALAAAALALALAALA 1103
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 497 AEGRGRYCIATPEMNDIFRRRHEIERDLREAVAEGGQIHVLYQPIFDAEERIVAAEALVRWNHP----ILGQMGPETFLS 572
Cdd:COG3321 1104 AALLLLALLAALALAAAAAALLALAALLAAAAAAAALAAAAAAAAALALAAAAAALAAALAAALlaaaALLLALALALAA 1183
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 573 IAEETGLIDRIGHHVLEQACILAATSGIPRVSVNISPVQLRQETFADEVLAVMAAHSLSGERLVLELTEKFTLDAGPATL 652
Cdd:COG3321 1184 ALAAALAGLAALLLAALLAALLAALLALALAALAAAAAALLAAAAAAAALALLALAAAAAAVAALAAAAAALLAALAALA 1263
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499658306 653 ANLARLRAAGVSIALDDFATGQSLLRYVRDYQIDTIKIDRSYVARLGTGDGTDQIVRAILDLGRAMGIEVTAEGVERASQ 732
Cdd:COG3321 1264 LLAAAAGLAALAAAAAAAAAALALAAAAAAAAAALAALLAAAAAAAAAAAAAAAAAALAAALLAAALAALAAAVAAALAL 1343
|
490 500 510
....*....|....*....|....*....|..
gi 499658306 733 REALLGMGCHGFQGYLLGRPMDPLRLAALSAR 764
Cdd:COG3321 1344 AAAAAAAAAAAAAAAAAAALAAAAGAAAAAAA 1375
|
|
| |
