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Conserved domains on  [gi|499665014|ref|WP_011345748|]
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MULTISPECIES: DNA topoisomerase [Xanthomonas]

Protein Classification

DNA topoisomerase III family protein( domain architecture ID 1002229)

DNA topoisomerase III is a type IA DNA topoisomerase that resolves single strand DNA recombination and replication intermediates

CATH:  2.70.20.10|1.10.460.10|3.40.50.140|1.10.290.10
EC:  5.6.2.1
Gene Ontology:  GO:0003917|GO:0006310|GO:0098847|GO:0051304|GO:0006261|GO:0006265
PubMed:  19208647

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PRK07726 super family cl35606
DNA topoisomerase 3;
5-719 0e+00

DNA topoisomerase 3;


The actual alignment was detected with superfamily member PRK07726:

Pssm-ID: 236078 [Multi-domain]  Cd Length: 658  Bit Score: 627.96  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014   5 KLYVAEKPSVGKALAGHLaksaPAVGRSGSHIEGSNWAVCWLRGHVYQLAEPDYYIERtYpeaKRgangrfpWLFDHLPL 84
Cdd:PRK07726   2 RLFIAEKPSVGRDIADVL----KPHKKGDGYIEGNGYIVTWAIGHLLELAEPEAYDER-Y---KR-------WRLEDLPI 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014  85 LPanDEWRLVPVSDKAEMIDAVRKLLTRATVVVHAGDIDREGQLLVDEVLEDLRCRVPVKRVLPKAIDDVSVQRVLADER 164
Cdd:PRK07726  67 IP--EKWKLVVKKKTAKQFNVVKKLLKQATEIVIATDADREGELIAREILDYCGVRKPIKRLWISSLTDKAIKRAFANLK 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 165 DNRDFARMRDAAIARGRADWLVGMNYSRCVTLQAREAGSTGHVSIGRVQTPVLGLIASRELEIRNFKPVDYLVLTAMIAv 244
Cdd:PRK07726 145 PGKETIPLYYSALARSRADWLVGINMTRAYTLLGRKAGYNGVLSVGRVQTPTLALVVRRDEEIENFVPKPYWEVEAHLT- 223

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 245 QAGKFRAKWRPRNGqpGIDENGRLLDAAVAAMVHQQVAGKTGRIAEYRDEQKNENAPLPFSLDELQRLASRRYGMGLEQT 324
Cdd:PRK07726 224 PGERFTAKWQPSEP--YQDEEGRLLDRPLAEQVVARIQGQPAKVTEVETKRKKEYAPLLYDLSELQIDANKRFGLSAKET 301

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 325 LKVVQGLYDS-KLVTYPRTDCAYLPMSQHAEAAEIVQAVREGfrGTDLPAQLSQLDIGRKSRAFDDKRVTAHHGIVPTPK 403
Cdd:PRK07726 302 LDIAQSLYEThKLITYPRTDSRYLPEDMVATLPEVLNAISKV--DPYLLLAPPVLDPSIRSRAWNDKKVTAHHAIIPTEQ 379

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 404 AANLEALSREERLIYEDIARRYLAQFMPPHTYRKVSVRAEVANHDFIASGRTTLKPGWKELYGKAEQAADddaapqdkgD 483
Cdd:PRK07726 380 PPNLSKLSEDERKVYDLIARRYLAQFLPPAEYDKTTIELEIAGGTFIAKGKQVVEAGWKALLGKKEEDEE---------K 450

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 484 DVNLPAMRQDEAARCEGLDRENKKTEPPSRFTDDTLLEAMVNIHKYVTTPQVKahfvAMLKKSEagaddqaqgcGIGTPA 563
Cdd:PRK07726 451 EQPLPVLAKGDELKVEKGEVKEGQTQPPKRFTEGTLLSAMENIARFVQDKELK----KTLKETD----------GLGTEA 516

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 564 TRHTFAPKLIEIGVVEhiagkKKAKFFAPTAAGLALYEALPRSLTVPDATAVWDMAFAKIEAGEITLEQFMAFQARQINA 643
Cdd:PRK07726 517 TRAGIIEKLFKRGYLE-----KKGKYIHATDKGKQLIDALPEELTSPDMTAKWEQALDQISEGQLSYQDFMQPLKQWLKQ 591

                        650       660       670       680       690       700       710
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 499665014 644 MLAEIRQlrivlpdlgprrvpptktagkrktaSKGGKKANGGSGAPCEKCAKGtMQLRNSSRGPFYGCSNFPVCKH 719
Cdd:PRK07726 592 LVEQAKQ-------------------------SSEKYKFDNLTGPKCPDCGKP-MLKVKGKNGKMLVCQDRECGKR 641
 
Name Accession Description Interval E-value
PRK07726 PRK07726
DNA topoisomerase 3;
5-719 0e+00

DNA topoisomerase 3;


Pssm-ID: 236078 [Multi-domain]  Cd Length: 658  Bit Score: 627.96  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014   5 KLYVAEKPSVGKALAGHLaksaPAVGRSGSHIEGSNWAVCWLRGHVYQLAEPDYYIERtYpeaKRgangrfpWLFDHLPL 84
Cdd:PRK07726   2 RLFIAEKPSVGRDIADVL----KPHKKGDGYIEGNGYIVTWAIGHLLELAEPEAYDER-Y---KR-------WRLEDLPI 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014  85 LPanDEWRLVPVSDKAEMIDAVRKLLTRATVVVHAGDIDREGQLLVDEVLEDLRCRVPVKRVLPKAIDDVSVQRVLADER 164
Cdd:PRK07726  67 IP--EKWKLVVKKKTAKQFNVVKKLLKQATEIVIATDADREGELIAREILDYCGVRKPIKRLWISSLTDKAIKRAFANLK 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 165 DNRDFARMRDAAIARGRADWLVGMNYSRCVTLQAREAGSTGHVSIGRVQTPVLGLIASRELEIRNFKPVDYLVLTAMIAv 244
Cdd:PRK07726 145 PGKETIPLYYSALARSRADWLVGINMTRAYTLLGRKAGYNGVLSVGRVQTPTLALVVRRDEEIENFVPKPYWEVEAHLT- 223

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 245 QAGKFRAKWRPRNGqpGIDENGRLLDAAVAAMVHQQVAGKTGRIAEYRDEQKNENAPLPFSLDELQRLASRRYGMGLEQT 324
Cdd:PRK07726 224 PGERFTAKWQPSEP--YQDEEGRLLDRPLAEQVVARIQGQPAKVTEVETKRKKEYAPLLYDLSELQIDANKRFGLSAKET 301

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 325 LKVVQGLYDS-KLVTYPRTDCAYLPMSQHAEAAEIVQAVREGfrGTDLPAQLSQLDIGRKSRAFDDKRVTAHHGIVPTPK 403
Cdd:PRK07726 302 LDIAQSLYEThKLITYPRTDSRYLPEDMVATLPEVLNAISKV--DPYLLLAPPVLDPSIRSRAWNDKKVTAHHAIIPTEQ 379

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 404 AANLEALSREERLIYEDIARRYLAQFMPPHTYRKVSVRAEVANHDFIASGRTTLKPGWKELYGKAEQAADddaapqdkgD 483
Cdd:PRK07726 380 PPNLSKLSEDERKVYDLIARRYLAQFLPPAEYDKTTIELEIAGGTFIAKGKQVVEAGWKALLGKKEEDEE---------K 450

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 484 DVNLPAMRQDEAARCEGLDRENKKTEPPSRFTDDTLLEAMVNIHKYVTTPQVKahfvAMLKKSEagaddqaqgcGIGTPA 563
Cdd:PRK07726 451 EQPLPVLAKGDELKVEKGEVKEGQTQPPKRFTEGTLLSAMENIARFVQDKELK----KTLKETD----------GLGTEA 516

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 564 TRHTFAPKLIEIGVVEhiagkKKAKFFAPTAAGLALYEALPRSLTVPDATAVWDMAFAKIEAGEITLEQFMAFQARQINA 643
Cdd:PRK07726 517 TRAGIIEKLFKRGYLE-----KKGKYIHATDKGKQLIDALPEELTSPDMTAKWEQALDQISEGQLSYQDFMQPLKQWLKQ 591

                        650       660       670       680       690       700       710
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 499665014 644 MLAEIRQlrivlpdlgprrvpptktagkrktaSKGGKKANGGSGAPCEKCAKGtMQLRNSSRGPFYGCSNFPVCKH 719
Cdd:PRK07726 592 LVEQAKQ-------------------------SSEKYKFDNLTGPKCPDCGKP-MLKVKGKNGKMLVCQDRECGKR 641
topB TIGR01056
DNA topoisomerase III, bacteria and conjugative plasmid; This model describes topoisomerase ...
 5-722 4.84e-159

DNA topoisomerase III, bacteria and conjugative plasmid; This model describes topoisomerase III from bacteria and its equivalents encoded on plasmids. The gene is designated topB if found in the bacterial chromosome, traE on conjugative plasmid RP4, etc. These enzymes are involved in the control of DNA topology. DNA topoisomerase III belongs to the type I topoisomerases, which are ATP-independent. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273419 [Multi-domain]  Cd Length: 660  Bit Score: 475.10  E-value: 4.84e-159
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014    5 KLYVAEKPSVGKALAGHLAKSApavgRSGSHIE-GSNWAVCWLRGHVYQLAEPDYYIERtYPEakrgangrfpWLFDHLP 83
Cdd:TIGR01056   2 TLVLCEKPSQARDLATVLAKKK----KGNGYLEiGVGGFVTWAVGHLVELAEPEEYDEK-YKN----------WRTYDLP 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014   84 LLPanDEWRLVPVSDKAEMIDAVRKLLTRATV--VVHAGDIDREGQLLVDEVLEDLRCR--VPVKRVLPKAIDDVSVQRV 159
Cdd:TIGR01056  67 LEP--EDWQLVVSDKTKKQFNVIKRILKENKVdeVVIATDPDREGELIAREILDYLKVTdkVTIKRLWISSLVDSSIRKA 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014  160 LADERDNRDFARMRDAAIARGRADWLVGMNYSRCVTLQAREAGSTGHVSIGRVQTPVLGLIASRELEIRNFKPVDYLVLT 239
Cdd:TIGR01056 145 FKNLRPKSETEGLYKSGVARARADWLVGINLTRAFTKLGREAGNDGVLSVGRVQTPTLAMVVKRENEIKNFVGKPFYEVS 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014  240 AMIAVQAGKFRAKWrprngQPGIDENGRLLDAAVAAMVHQQVAGKTGRIAEYRDEQKNENAPLPFSLDELQRLASRRYGM 319
Cdd:TIGR01056 225 ATINKDEQEFTTEW-----QPYKDEEERELHEFLAENVVTDLTQKPALVTDIEKERKKTSAPLFYDLSALQEDANKRFGI 299

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014  320 GLEQTLKVVQGLYDS-KLVTYPRTDCAYLPMSQHAEaaeiVQAVREGFRGTDlPAQLSQ--LDIGRKSRAFDDKRVTAHH 396
Cdd:TIGR01056 300 SAKRTLDIAQKLYEThKLITYPRTDSRYLPEDEKEM----LLEVLDALKVIT-PALLPIkkRDELTNNRLWNDKKIEDHH 374

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014  397 GIVPTPKAANLEALSREERLIYEDIARRYLAQFMPPHTYRKVSVRAEVANHDFIASGRTTLKPGWKELYGKAEqaaddda 476
Cdd:TIGR01056 375 AIIPTGNDFNLSDLSEEERNVYKLIAQNYLMQFMPKEEYETTTIEIAIGKLMFEAKGKILQDNGWKALLGKQE------- 447

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014  477 aPQDKGDDVNLPAMRQDEAARCEGLDRENKKTEPPSRFTDDTLLEAMVNIHKYVTTPQVKahfvAMLKKSEagaddqaqg 556
Cdd:TIGR01056 448 -EDEETEDTTLPAFQKGDELDVETLELLEKQTKPPARYTEGTLLSAMTNPAAFVQDKGLK----KTLKETK--------- 513

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014  557 cGIGTPATRHTFAPKLIEIGVVEhiagKKKAKFFApTAAGLALYEALPRSLTVPDATAVWDMAFAKIEAGEITLEQFMAF 636
Cdd:TIGR01056 514 -GLGTEATRADIIENLFKRGFIQ----KKKNKIYI-TKNGKLLCLLLPELLTKPDLTAQWEQYLNGISAGEKDDDDFINT 587

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014  637 QARQINAMLAEIRQLRIVLpdlgpRRVPPTKTAGKRKTASKggKKANGgsgaPCEKCaKGTMQLRNSSRGPFYGCsnfpV 716
Cdd:TIGR01056 588 INEMIKQTINEEKKNPETI-----QKVAKEPVSCGGIAKCP--AKDNG----RLIDC-KKFPECTEYGNGCEFTI----P 651


                  ....*.
gi 499665014  717 CKHTAP 722
Cdd:TIGR01056 652 KKLREK 657
TopA COG0550
DNA topoisomerase IA [Replication, recombination and repair];
5-634 1.42e-127

DNA topoisomerase IA [Replication, recombination and repair];


Pssm-ID: 440316 [Multi-domain]  Cd Length: 541  Bit Score: 389.84  E-value: 1.42e-127
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014   5 KLYVAEKPSVGKALAGHLaksapavgrsgshieGSNWAVCWLRGHVYQLAEPdyyiERTYPEAKrgangrfpwlfDHLPl 84
Cdd:COG0550    2 KLVIVESPAKAKTIAKYL---------------GKDYVVTASVGHLRDLPKP----ELDVDVEN-----------DFEP- 50

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014  85 lpandewRLVPVSDKAEMIDAVRKLLTRATVVVHAGDIDREGQLLVDEVLEDLRCRVPVKRVLPKAIDDVSVQRVLADER 164
Cdd:COG0550   51 -------KYEVIPGKKKQVKELKKLAKKADEVILATDPDREGEAIAWHLLELLGDKKPVKRVVFNEITKKAIKEAFKNPR 123

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 165 DnrDFARMRDAAIARGRADWLVGMNYSRCVTLQAREAgstghVSIGRVQTPVLGLIASRELEIRNFKPVDYLVLTAMIAV 244
Cdd:COG0550  124 D--IDMNLVDAQQARRILDRLVGYNLSPLLWKKVKRG-----LSAGRVQSPALRLIVEREREIEAFVPEEYWTIEATFKT 196

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 245 QAGKFRAKWRPRNGQpgidengRLLDAAVAAMVHQQVAGKTGRIAEYRDEQKNENAPLPFSLDELQRLASRRYGMGLEQT 324
Cdd:COG0550  197 GGGEFTAKLVKIDGK-------KILDEEEAEAILAALKGKTFTVTSVEKKPKKRNPPPPFTTSTLQQEASRKLGFSAKKT 269

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 325 LKVVQGLYDSKLVTYPRTDCAYLPmsqhaeaAEIVQAVREgfrgtdlpaQLSQLD----IGRKSRAFD--DKRVTAHHGI 398
Cdd:COG0550  270 MSIAQRLYEVGLITYMRTDSVRLS-------EDAVAAARE---------YIEALYgkeyLPEKPRVYKtsKNAQEAHEAI 333

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 399 VPTPKAANLEALSREERLIYEDIARRYLAQFMPPHTYRKVSVRAEVANHDFIASGRTTLKPGWKELYGKAEqaadddaAP 478
Cdd:COG0550  334 RPTGVTRTPESLSGDEFKLYDLIWKRFLASQMPPAEYETTTVTIEVGGEEFRASGKVIKFPGFLKVYGEGK-------DD 406

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 479 QDKGDDVNLPAMRQDEAARCEGLDRENKKTEPPSRFTDDTLLEAMvnihkyvttpqvkahfvamlkkseagaddqaQGCG 558
Cdd:COG0550  407 EEEEEEKRLPPLKEGEKLKLKKIEPEQHFTKPPPRYTEASLVKAM-------------------------------EELG 455

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 559 IGTPATRhtfAP---KLIEIGVVEhiagkKKAKFFAPTAAGLALYEALPRS---LTVPDATAVWDMAFAKIEAGEITLEQ 632
Cdd:COG0550  456 IGRPSTY---ASiieTLQDRGYVE-----REGKRLVPTELGFIVIDLLEEHfpdLVDYEFTAKMEEKLDEIAEGKLDWKD 527


                 ..
gi 499665014 633 FM 634
Cdd:COG0550  528 VL 529
Topoisom_bac pfam01131
DNA topoisomerase; This subfamily of topoisomerase is divided on the basis that these enzymes ...
 174-635 2.37e-117

DNA topoisomerase; This subfamily of topoisomerase is divided on the basis that these enzymes preferentially relax negatively supercoiled DNA, from a 5' phospho- tyrosine linkage in the enzyme-DNA covalent intermediate and has high affinity for single stranded DNA.


Pssm-ID: 426069 [Multi-domain]  Cd Length: 410  Bit Score: 358.86  E-value: 2.37e-117
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014  174 DAAIARGRADWLVGMNYSRCVTLQAREAGStghVSIGRVQTPVLGLIASRELEIRNFKPVDYLVLTAMIAVQAGKFRAKw 253
Cdd:pfam01131   8 DAQLARRELDWLIGFNLSRLLTLKLKGNKL---LSAGRVQTPTLALIVEREREIENFVPEPYWTIEATLKDGGGVFANA- 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014  254 rprngqpgIDENGRLLDAAVAAMVHQQVAGKTGRIAEYRDEQKNENAPLPFSLDELQRLASRRYGMGLEQTLKVVQGLY- 332
Cdd:pfam01131  84 --------KWKRGRIFDKEEAEAILEKLKKGTAVVTSVESKEKKKPPPLPFNTTTLQKEASRKLGFSAKKTMSIAQKLYe 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014  333 DSKLVTYPRTDCAYLPmsQHAEAAEIVQAVREGFrGTDLPAQLSQLDIGRKSRAFDDKRVTAHHGIVPTPKAANLEALSR 412
Cdd:pfam01131 156 KHGLITYPRTDSTYLS--DDATLKAILEYLTKNY-GKYLPYAPRLLKKTKGKLTVGNAKVTAHEAIRPTGDIPVLPELSD 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014  413 EERLIYEDIARRYLAQFMPPHTYRKVSVRAEVANHDFIASGRTTLKPGWKELYGKAEqaadddaapqdKGDDVNLPAMRQ 492
Cdd:pfam01131 233 DERKLYELIVRRFLASQMPPAVYETTTVVLEVGGEEFRASGKVILEDGWLKVYPYEK-----------KEDEEELPELKE 301

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014  493 DEAARCEGLDRENKKTEPPSRFTDDTLLEAMVNihkyvttpqvkahfvamlkkseagaddqaqgCGIGTPATRHTFAPKL 572
Cdd:pfam01131 302 GEELKVTQVEVEEKKTKPPPRYTEASLIKAMEK-------------------------------AGIGTPATRATIIETL 350

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 499665014  573 IEIGVVEhiagkKKAKFFAPTAAGLALYEALPRSLTV--PDATAVWDMAFAKIEAGEITLEQFMA 635
Cdd:pfam01131 351 LERGYVE-----RKKKSLVPTELGKALVEALEKFPDLvdPELTAELEEKLDEIAEGKLDWKDVLA 410
TOP1Ac cd00186
DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA ...
 174-648 9.30e-84

DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA and then rejoin the broken phosphodiester backbone. Proposed catalytic mechanism of single stranded DNA cleavage is by phosphoryl transfer through a tyrosine nucleophile using acid/base catalysis. Tyr is activated by a nearby group (not yet identified) acting as a general base for nucleophilic attack on the 5' phosphate of the scissile bond. Arg and Lys stabilize the pentavalent transition state. Glu then acts as a proton donor for the leaving 3'-oxygen, upon cleavage of the scissile strand.


Pssm-ID: 238110 [Multi-domain]  Cd Length: 381  Bit Score: 270.24  E-value: 9.30e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 174 DAAIARGRADWLVGMNYSRCVTLQAREAGStghVSIGRVQTPVLGLIASRELEIRNFKPVDYLVLtamiavqagkfrakw 253
Cdd:cd00186    5 NAQLARRILDRLVGFNLSRLLTKKLRRKGV---LSAGRVQSPTLGLIVEREREIKAFVPEDYWEI--------------- 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 254 rprngqpgidengrlldaavaamvhqqvagKTGRIAEYRDEQKNENAPLPFSLDELQRLASRRYGMGLEQTLKVVQGLYD 333
Cdd:cd00186   67 ------------------------------KEAVVVSVEKKEKKKNPPPPFTTSTLQQEASSKLGFSAKKTMQIAQKLYE 116

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 334 SKLVTYPRTDCAYLPMSQHAEAAEIVQAvREGFRGTDLPAQLsqldiGRKSRAFDDKRVTAHHGIVPT---PKAANLEAL 410
Cdd:cd00186  117 AGLITYPRTDSTRLSEEAILEAREYIQA-IYGKEYLYPAPLL-----GRRNPKRGKKEQGAHEAIRPTkvaPTPELEANL 190

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 411 SREERLIYEDIARRYLAQFMPPHTYRKVSVRAEVANHDFIASGRTTLKPGWKELYGKaeqaadddaapQDKGDDVNLPAM 490
Cdd:cd00186  191 SEDEFKLYELIWRRFLASQMADAKYEETTVTLEIGGEKFKASGKVLLEDGWLEVYPE-----------EKDDEEEEPPPL 259

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 491 RQDEAARCEGLDRENKKTEPPSRFTDDTLLEAMvnihkyvttpqvKAHfvamlkkseagaddqaqgcGIGTPATRHTFAP 570
Cdd:cd00186  260 KEGDELKLEEVELEEKETQPPPRYTEASLIKLM------------EKR-------------------GIGRPSTYASIIE 308

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 571 KLIEIGVVEhiagkKKAKFFAPTAAGLALYEALPR---SLTVPDATAVWDMAFAKIEAGEITLEQFMafqaRQINAMLAE 647
Cdd:cd00186  309 TLLDRGYVE-----KEKKKLIPTELGFAVIELLEKhfpELVDPEFTAKLEEKLDEIAEGKKDYQEVL----EEFYEEFKK 379


                 .
gi 499665014 648 I 648
Cdd:cd00186  380 I 380
TOP1Ac smart00437
Bacterial DNA topoisomerase I DNA-binding domain; Bacterial DNA topoisomerase I and III, ...
 292-599 2.14e-59

Bacterial DNA topoisomerase I DNA-binding domain; Bacterial DNA topoisomerase I and III, Eukaryotic DNA topoisomeraes III, reverse gyrase alpha subunit


Pssm-ID: 214663 [Multi-domain]  Cd Length: 259  Bit Score: 201.32  E-value: 2.14e-59
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014   292 RDEQKNENAPLPFSLDELQRLASRRYGMGLEQTLKVVQGLYDSKLVTYPRTDCAYLPMSQHAEAAEIVQAVReGFRGTDL 371
Cdd:smart00437   1 EEKEKKKNPPPPFTTSTLQQEASRKLGFSAKKTMQIAQKLYEKGLITYPRTDSTRLSEEAVLEARNYIQKLY-GKEYLDL 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014   372 PAQLSQldigRKSRAFDDKRVTAHHGIVPT---PKAANLEALSREERLIYEDIARRYLAQFMPPHTYRKVSVRAEVANHD 448
Cdd:smart00437  80 AVVLLK----PRKPRKGKKAQGAHEAIRPTkpiFTPELEKELSEDEFKLYELIWRRFLASQMPDAKYEETKVTIKIGGEK 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014   449 FIASGRTTLKPGWKELYGKAEqaadddaapqdKGDDVNLPAMRQDEAARCEGLDRENKKTEPPSRFTDDTLLEAMvnihk 528
Cdd:smart00437 156 FKAKGKTLLFDGWLKVYPEEK-----------KEEEIELPTLKKGDELKVEEVEVEEKETKPPARYTEASLIKLM----- 219

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 499665014   529 yvttpqvkahfvamlKKSeagaddqaqgcGIGTPATRHTFAPKLIEIGVVEhiagkKKAKFFAPTAAGLAL 599
Cdd:smart00437 220 ---------------EKR-----------GIGRPSTYASIIETLLDRGYVT-----KKKKKLIPTELGIAV 259
 
Name Accession Description Interval E-value
PRK07726 PRK07726
DNA topoisomerase 3;
5-719 0e+00

DNA topoisomerase 3;


Pssm-ID: 236078 [Multi-domain]  Cd Length: 658  Bit Score: 627.96  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014   5 KLYVAEKPSVGKALAGHLaksaPAVGRSGSHIEGSNWAVCWLRGHVYQLAEPDYYIERtYpeaKRgangrfpWLFDHLPL 84
Cdd:PRK07726   2 RLFIAEKPSVGRDIADVL----KPHKKGDGYIEGNGYIVTWAIGHLLELAEPEAYDER-Y---KR-------WRLEDLPI 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014  85 LPanDEWRLVPVSDKAEMIDAVRKLLTRATVVVHAGDIDREGQLLVDEVLEDLRCRVPVKRVLPKAIDDVSVQRVLADER 164
Cdd:PRK07726  67 IP--EKWKLVVKKKTAKQFNVVKKLLKQATEIVIATDADREGELIAREILDYCGVRKPIKRLWISSLTDKAIKRAFANLK 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 165 DNRDFARMRDAAIARGRADWLVGMNYSRCVTLQAREAGSTGHVSIGRVQTPVLGLIASRELEIRNFKPVDYLVLTAMIAv 244
Cdd:PRK07726 145 PGKETIPLYYSALARSRADWLVGINMTRAYTLLGRKAGYNGVLSVGRVQTPTLALVVRRDEEIENFVPKPYWEVEAHLT- 223

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 245 QAGKFRAKWRPRNGqpGIDENGRLLDAAVAAMVHQQVAGKTGRIAEYRDEQKNENAPLPFSLDELQRLASRRYGMGLEQT 324
Cdd:PRK07726 224 PGERFTAKWQPSEP--YQDEEGRLLDRPLAEQVVARIQGQPAKVTEVETKRKKEYAPLLYDLSELQIDANKRFGLSAKET 301

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 325 LKVVQGLYDS-KLVTYPRTDCAYLPMSQHAEAAEIVQAVREGfrGTDLPAQLSQLDIGRKSRAFDDKRVTAHHGIVPTPK 403
Cdd:PRK07726 302 LDIAQSLYEThKLITYPRTDSRYLPEDMVATLPEVLNAISKV--DPYLLLAPPVLDPSIRSRAWNDKKVTAHHAIIPTEQ 379

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 404 AANLEALSREERLIYEDIARRYLAQFMPPHTYRKVSVRAEVANHDFIASGRTTLKPGWKELYGKAEQAADddaapqdkgD 483
Cdd:PRK07726 380 PPNLSKLSEDERKVYDLIARRYLAQFLPPAEYDKTTIELEIAGGTFIAKGKQVVEAGWKALLGKKEEDEE---------K 450

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 484 DVNLPAMRQDEAARCEGLDRENKKTEPPSRFTDDTLLEAMVNIHKYVTTPQVKahfvAMLKKSEagaddqaqgcGIGTPA 563
Cdd:PRK07726 451 EQPLPVLAKGDELKVEKGEVKEGQTQPPKRFTEGTLLSAMENIARFVQDKELK----KTLKETD----------GLGTEA 516

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 564 TRHTFAPKLIEIGVVEhiagkKKAKFFAPTAAGLALYEALPRSLTVPDATAVWDMAFAKIEAGEITLEQFMAFQARQINA 643
Cdd:PRK07726 517 TRAGIIEKLFKRGYLE-----KKGKYIHATDKGKQLIDALPEELTSPDMTAKWEQALDQISEGQLSYQDFMQPLKQWLKQ 591

                        650       660       670       680       690       700       710
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 499665014 644 MLAEIRQlrivlpdlgprrvpptktagkrktaSKGGKKANGGSGAPCEKCAKGtMQLRNSSRGPFYGCSNFPVCKH 719
Cdd:PRK07726 592 LVEQAKQ-------------------------SSEKYKFDNLTGPKCPDCGKP-MLKVKGKNGKMLVCQDRECGKR 641
topB TIGR01056
DNA topoisomerase III, bacteria and conjugative plasmid; This model describes topoisomerase ...
 5-722 4.84e-159

DNA topoisomerase III, bacteria and conjugative plasmid; This model describes topoisomerase III from bacteria and its equivalents encoded on plasmids. The gene is designated topB if found in the bacterial chromosome, traE on conjugative plasmid RP4, etc. These enzymes are involved in the control of DNA topology. DNA topoisomerase III belongs to the type I topoisomerases, which are ATP-independent. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273419 [Multi-domain]  Cd Length: 660  Bit Score: 475.10  E-value: 4.84e-159
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014    5 KLYVAEKPSVGKALAGHLAKSApavgRSGSHIE-GSNWAVCWLRGHVYQLAEPDYYIERtYPEakrgangrfpWLFDHLP 83
Cdd:TIGR01056   2 TLVLCEKPSQARDLATVLAKKK----KGNGYLEiGVGGFVTWAVGHLVELAEPEEYDEK-YKN----------WRTYDLP 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014   84 LLPanDEWRLVPVSDKAEMIDAVRKLLTRATV--VVHAGDIDREGQLLVDEVLEDLRCR--VPVKRVLPKAIDDVSVQRV 159
Cdd:TIGR01056  67 LEP--EDWQLVVSDKTKKQFNVIKRILKENKVdeVVIATDPDREGELIAREILDYLKVTdkVTIKRLWISSLVDSSIRKA 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014  160 LADERDNRDFARMRDAAIARGRADWLVGMNYSRCVTLQAREAGSTGHVSIGRVQTPVLGLIASRELEIRNFKPVDYLVLT 239
Cdd:TIGR01056 145 FKNLRPKSETEGLYKSGVARARADWLVGINLTRAFTKLGREAGNDGVLSVGRVQTPTLAMVVKRENEIKNFVGKPFYEVS 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014  240 AMIAVQAGKFRAKWrprngQPGIDENGRLLDAAVAAMVHQQVAGKTGRIAEYRDEQKNENAPLPFSLDELQRLASRRYGM 319
Cdd:TIGR01056 225 ATINKDEQEFTTEW-----QPYKDEEERELHEFLAENVVTDLTQKPALVTDIEKERKKTSAPLFYDLSALQEDANKRFGI 299

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014  320 GLEQTLKVVQGLYDS-KLVTYPRTDCAYLPMSQHAEaaeiVQAVREGFRGTDlPAQLSQ--LDIGRKSRAFDDKRVTAHH 396
Cdd:TIGR01056 300 SAKRTLDIAQKLYEThKLITYPRTDSRYLPEDEKEM----LLEVLDALKVIT-PALLPIkkRDELTNNRLWNDKKIEDHH 374

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014  397 GIVPTPKAANLEALSREERLIYEDIARRYLAQFMPPHTYRKVSVRAEVANHDFIASGRTTLKPGWKELYGKAEqaaddda 476
Cdd:TIGR01056 375 AIIPTGNDFNLSDLSEEERNVYKLIAQNYLMQFMPKEEYETTTIEIAIGKLMFEAKGKILQDNGWKALLGKQE------- 447

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014  477 aPQDKGDDVNLPAMRQDEAARCEGLDRENKKTEPPSRFTDDTLLEAMVNIHKYVTTPQVKahfvAMLKKSEagaddqaqg 556
Cdd:TIGR01056 448 -EDEETEDTTLPAFQKGDELDVETLELLEKQTKPPARYTEGTLLSAMTNPAAFVQDKGLK----KTLKETK--------- 513

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014  557 cGIGTPATRHTFAPKLIEIGVVEhiagKKKAKFFApTAAGLALYEALPRSLTVPDATAVWDMAFAKIEAGEITLEQFMAF 636
Cdd:TIGR01056 514 -GLGTEATRADIIENLFKRGFIQ----KKKNKIYI-TKNGKLLCLLLPELLTKPDLTAQWEQYLNGISAGEKDDDDFINT 587

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014  637 QARQINAMLAEIRQLRIVLpdlgpRRVPPTKTAGKRKTASKggKKANGgsgaPCEKCaKGTMQLRNSSRGPFYGCsnfpV 716
Cdd:TIGR01056 588 INEMIKQTINEEKKNPETI-----QKVAKEPVSCGGIAKCP--AKDNG----RLIDC-KKFPECTEYGNGCEFTI----P 651


                  ....*.
gi 499665014  717 CKHTAP 722
Cdd:TIGR01056 652 KKLREK 657
TopA COG0550
DNA topoisomerase IA [Replication, recombination and repair];
5-634 1.42e-127

DNA topoisomerase IA [Replication, recombination and repair];


Pssm-ID: 440316 [Multi-domain]  Cd Length: 541  Bit Score: 389.84  E-value: 1.42e-127
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014   5 KLYVAEKPSVGKALAGHLaksapavgrsgshieGSNWAVCWLRGHVYQLAEPdyyiERTYPEAKrgangrfpwlfDHLPl 84
Cdd:COG0550    2 KLVIVESPAKAKTIAKYL---------------GKDYVVTASVGHLRDLPKP----ELDVDVEN-----------DFEP- 50

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014  85 lpandewRLVPVSDKAEMIDAVRKLLTRATVVVHAGDIDREGQLLVDEVLEDLRCRVPVKRVLPKAIDDVSVQRVLADER 164
Cdd:COG0550   51 -------KYEVIPGKKKQVKELKKLAKKADEVILATDPDREGEAIAWHLLELLGDKKPVKRVVFNEITKKAIKEAFKNPR 123

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 165 DnrDFARMRDAAIARGRADWLVGMNYSRCVTLQAREAgstghVSIGRVQTPVLGLIASRELEIRNFKPVDYLVLTAMIAV 244
Cdd:COG0550  124 D--IDMNLVDAQQARRILDRLVGYNLSPLLWKKVKRG-----LSAGRVQSPALRLIVEREREIEAFVPEEYWTIEATFKT 196

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 245 QAGKFRAKWRPRNGQpgidengRLLDAAVAAMVHQQVAGKTGRIAEYRDEQKNENAPLPFSLDELQRLASRRYGMGLEQT 324
Cdd:COG0550  197 GGGEFTAKLVKIDGK-------KILDEEEAEAILAALKGKTFTVTSVEKKPKKRNPPPPFTTSTLQQEASRKLGFSAKKT 269

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 325 LKVVQGLYDSKLVTYPRTDCAYLPmsqhaeaAEIVQAVREgfrgtdlpaQLSQLD----IGRKSRAFD--DKRVTAHHGI 398
Cdd:COG0550  270 MSIAQRLYEVGLITYMRTDSVRLS-------EDAVAAARE---------YIEALYgkeyLPEKPRVYKtsKNAQEAHEAI 333

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 399 VPTPKAANLEALSREERLIYEDIARRYLAQFMPPHTYRKVSVRAEVANHDFIASGRTTLKPGWKELYGKAEqaadddaAP 478
Cdd:COG0550  334 RPTGVTRTPESLSGDEFKLYDLIWKRFLASQMPPAEYETTTVTIEVGGEEFRASGKVIKFPGFLKVYGEGK-------DD 406

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 479 QDKGDDVNLPAMRQDEAARCEGLDRENKKTEPPSRFTDDTLLEAMvnihkyvttpqvkahfvamlkkseagaddqaQGCG 558
Cdd:COG0550  407 EEEEEEKRLPPLKEGEKLKLKKIEPEQHFTKPPPRYTEASLVKAM-------------------------------EELG 455

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 559 IGTPATRhtfAP---KLIEIGVVEhiagkKKAKFFAPTAAGLALYEALPRS---LTVPDATAVWDMAFAKIEAGEITLEQ 632
Cdd:COG0550  456 IGRPSTY---ASiieTLQDRGYVE-----REGKRLVPTELGFIVIDLLEEHfpdLVDYEFTAKMEEKLDEIAEGKLDWKD 527


                 ..
gi 499665014 633 FM 634
Cdd:COG0550  528 VL 529
Topoisom_bac pfam01131
DNA topoisomerase; This subfamily of topoisomerase is divided on the basis that these enzymes ...
 174-635 2.37e-117

DNA topoisomerase; This subfamily of topoisomerase is divided on the basis that these enzymes preferentially relax negatively supercoiled DNA, from a 5' phospho- tyrosine linkage in the enzyme-DNA covalent intermediate and has high affinity for single stranded DNA.


Pssm-ID: 426069 [Multi-domain]  Cd Length: 410  Bit Score: 358.86  E-value: 2.37e-117
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014  174 DAAIARGRADWLVGMNYSRCVTLQAREAGStghVSIGRVQTPVLGLIASRELEIRNFKPVDYLVLTAMIAVQAGKFRAKw 253
Cdd:pfam01131   8 DAQLARRELDWLIGFNLSRLLTLKLKGNKL---LSAGRVQTPTLALIVEREREIENFVPEPYWTIEATLKDGGGVFANA- 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014  254 rprngqpgIDENGRLLDAAVAAMVHQQVAGKTGRIAEYRDEQKNENAPLPFSLDELQRLASRRYGMGLEQTLKVVQGLY- 332
Cdd:pfam01131  84 --------KWKRGRIFDKEEAEAILEKLKKGTAVVTSVESKEKKKPPPLPFNTTTLQKEASRKLGFSAKKTMSIAQKLYe 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014  333 DSKLVTYPRTDCAYLPmsQHAEAAEIVQAVREGFrGTDLPAQLSQLDIGRKSRAFDDKRVTAHHGIVPTPKAANLEALSR 412
Cdd:pfam01131 156 KHGLITYPRTDSTYLS--DDATLKAILEYLTKNY-GKYLPYAPRLLKKTKGKLTVGNAKVTAHEAIRPTGDIPVLPELSD 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014  413 EERLIYEDIARRYLAQFMPPHTYRKVSVRAEVANHDFIASGRTTLKPGWKELYGKAEqaadddaapqdKGDDVNLPAMRQ 492
Cdd:pfam01131 233 DERKLYELIVRRFLASQMPPAVYETTTVVLEVGGEEFRASGKVILEDGWLKVYPYEK-----------KEDEEELPELKE 301

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014  493 DEAARCEGLDRENKKTEPPSRFTDDTLLEAMVNihkyvttpqvkahfvamlkkseagaddqaqgCGIGTPATRHTFAPKL 572
Cdd:pfam01131 302 GEELKVTQVEVEEKKTKPPPRYTEASLIKAMEK-------------------------------AGIGTPATRATIIETL 350

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 499665014  573 IEIGVVEhiagkKKAKFFAPTAAGLALYEALPRSLTV--PDATAVWDMAFAKIEAGEITLEQFMA 635
Cdd:pfam01131 351 LERGYVE-----RKKKSLVPTELGKALVEALEKFPDLvdPELTAELEEKLDEIAEGKLDWKDVLA 410
PRK08173 PRK08173
DNA topoisomerase III; Validated
 5-648 6.19e-89

DNA topoisomerase III; Validated


Pssm-ID: 236172 [Multi-domain]  Cd Length: 862  Bit Score: 297.35  E-value: 6.19e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014   5 KLYVAEKPSVgkalAGHLAKSAPAVGRSGSHIEGSNWAVCWLRGHVYQLAEPDYYiertypEAKRGAngrfpWLFDHLPL 84
Cdd:PRK08173   4 ALIIAEKPSV----ANDIARALGGFTKHDEYFESDEYVLSSAVGHLLEIAAPEEY------EVKRGK-----WSFAHLPV 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014  85 LPanDEWRLVPVSDKAEMIDAVRKLLTR--ATVVVHAGDIDREGQLLVDEVLEDLRCRVPVKRV-----LPKAIDDVsvq 157
Cdd:PRK08173  69 IP--PHFDLNPIAKTESRLKVLTKLIKRkdVTRLINACDAGREGELIFRLIAQHAKAKKPVKRLwlqsmTPQAIRDG--- 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 158 rvLADERDNRDFARMRDAAIARGRADWLVGMNYSRCVTLQAREAGSTGHVSIGRVQTPVLGLIASRELEIRNFKPVDYLV 237
Cdd:PRK08173 144 --FANLRSDEDMQPLADAARCRSEADWLVGINGTRAMTAFNSKGGGFFLTTVGRVQTPTLSIVVEREEKIRRFVPRDYWE 221

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 238 LTAMIAVQAGKFRAKWrprngqpgIDEN------------GRLLDAAVAAMVHQQVAGKTGRIAEyrdEQK--NENAPLP 303
Cdd:PRK08173 222 VRAEFVAAAGFYEGRW--------FDPKfkkdefdpekraSRLWSEAAAEAIVAACRGKPGTVTE---ESKpsTQLSPLL 290

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 304 FSLDELQRLASRRYGMGLEQTLKVVQGLYDS-KLVTYPRTDCAYLPMSQHAEAAEIVQAVREGFRGTDLPAQ-LSQLDIG 381
Cdd:PRK08173 291 FDLTSLQREANGRFGFSAKNTLGLAQALYEKhKVLTYPRTDSRALPEDYLGTVKQTLEMLKESNNYLPHAKQiLDKGWVK 370

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 382 RKSRAFDDKRVTAHHGIVPTPKAAnlEALSREERLIYEDIARRYLAQFMPPHTYRkVSVR-AEVANHDFIASGRTTLKPG 460
Cdd:PRK08173 371 PNKRIFDNSKISDHFAIIPTLQAP--KSLSEPEQKLYDLVVKRFLAVFFPAAEFL-VTTRiTEVAGHHFKTEGKVLVNPG 447

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 461 WKELYGKAEQaadddaapqdkGDDVNLPAMRQDEAARCEGLDRENKKTEPPSRFTDDTLLEAMVNIHKYVTTPQVKAhfv 540
Cdd:PRK08173 448 WLAVYGKEAQ-----------GADANLVPVQKGEKVKTDKIEAVALTTKPPARYNEATLLSAMEGAGKLVEDDELRE--- 513

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 541 AMLKKseagaddqaqgcGIGTPATRHTFAPKLIEIGVVEhiagkKKAKFFAPTAAGLALYEALP----RSLTVPDATAVW 616
Cdd:PRK08173 514 AMAEK------------GLGTPATRAAIIEGLLGEKYLV-----REGRELIPTAKAFQLMTLLRglgvEELTSPELTGEW 576

                        650       660       670
                 ....*....|....*....|....*....|..
gi 499665014 617 DMAFAKIEAGEITLEQFMafqaRQINAMLAEI 648
Cdd:PRK08173 577 EYKLSQIERGKLSRDAFM----QEIAQMTQQI 604
PRK07219 PRK07219
DNA topoisomerase I; Validated
 4-722 4.33e-87

DNA topoisomerase I; Validated


Pssm-ID: 235971 [Multi-domain]  Cd Length: 822  Bit Score: 291.52  E-value: 4.33e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014   4 FKLYVAEKPSVGKALAGHLAKSAPAVGRSG--SHIE----GSNWAVCWLRGHVYQLAEPDYYieRTYPEakrgangrfpw 77
Cdd:PRK07219   1 TELIIAEKNNAARRIADILSGGKAKKKRVNgvPYYEferkGEKWIVIGLSGHIVTVDFPEEY--GDWRD----------- 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014  78 lFDhLPLLPANDewrLVPVSDKAEMIDAVRKLLTRATVVVHAGDIDREGQLLVDEVLEDLR--CRVPVKRVLPKAIDDVS 155
Cdd:PRK07219  68 -VD-PAELIDAD---PVKKITKQNYINALKKLAKDADEIIIATDYDREGELIGKEAYHILRevCQVPVKRARFSSLTKKE 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 156 VQRVLADErDNRDFArMRDAAIARGRADWLVGMNYSRCVTLQAREAGSTGHVSIGRVQTPVLGLIASRELEIRNFKPVDY 235
Cdd:PRK07219 143 IRKAFENP-DEIDFN-LADAGEARQIIDLYWGAALTRFLSLSVRQLGRWDFLSVGRVQTPTLAFIVDREREIRAFDPEDY 220

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 236 LVLTAMIAVQAGKFRAKWrprngqPGIDENGRLLDAAVAAMVHQQVAG-KTGRIAEYRDEQKNENAPLPFSLDELQRLAS 314
Cdd:PRK07219 221 WKIEALLDKEAQYFYRDL------IGGHEAEKFWDEEEAEEIYEKLKGaKEATVSSVKKRERTISPPAPFNTTEFLREAS 294

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 315 RRYGMGLEQTLKVVQGLYDSKLVTYPRTDCAYLPMSQHAEaaEIVQA-VREGFRGTDLPAQLSQLDIGRKSrafDDKRVT 393
Cdd:PRK07219 295 KIFGISPKRAMEIAEKLYTAGYISYPRTDNTVYPDDLDPK--ELLKKlSKKKEYGPYAESILEQENIKPTE---GKKETT 369

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 394 AHHGIVPTpKAANLEALSREERLIYEDIARRYLAQFMPPHTYRKVSVRAEVANHDFIASGRTTLKPGWKELYGkaeqaad 473
Cdd:PRK07219 370 DHPPIHPV-DVPKREELSDDEWKVYELIVRRFLATLADPAEWEYLKVELDVNGEIFKASGSRLVEEGWHEVYP------- 441

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 474 ddaapQDKGDDVNLPAMRQDEAARCEGLDRENKKTEPPSRFTDDTLLEAMVNIhkyvttpqvkahfvamlkkseagaddq 553
Cdd:PRK07219 442 -----YEKFDEKELPDLEEGEKLKVNKIEIEAKETQPPKRYTQSSLIKEMEKR--------------------------- 489

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 554 aqgcGIGTPATRHTFAPKLIEIGVVehIAGKKkakfFAPTAAGLALYEALPRS---LTVPDATAVWDMAFAKIEAGEITL 630
Cdd:PRK07219 490 ----GLGTKATRHDIIEKLYKRGYV--IEGDP----PRPTDLGIAVIEALEKYapeIVSEEMTAQLEADMQAIEDGKKKK 559

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 631 EQFMAFQARQINAMLAEIRQLRivlPDLGprrvppTKTAGKRKTASKGGKKAnggsgAPCEKCAkGTMQLRNSSRGP-FY 709
Cdd:PRK07219 560 EDVTEESREMLKEILSELKEKR---KEIG------DHLAGSLKAENRSLKTI-----GKCPECG-GDLIIIRTDKGSrFV 624

                        730
                 ....*....|...
gi 499665014 710 GCSNFPVCKHTAP 722
Cdd:PRK07219 625 GCSGYPDCRNTFP 637
TOP1Ac cd00186
DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA ...
 174-648 9.30e-84

DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA and then rejoin the broken phosphodiester backbone. Proposed catalytic mechanism of single stranded DNA cleavage is by phosphoryl transfer through a tyrosine nucleophile using acid/base catalysis. Tyr is activated by a nearby group (not yet identified) acting as a general base for nucleophilic attack on the 5' phosphate of the scissile bond. Arg and Lys stabilize the pentavalent transition state. Glu then acts as a proton donor for the leaving 3'-oxygen, upon cleavage of the scissile strand.


Pssm-ID: 238110 [Multi-domain]  Cd Length: 381  Bit Score: 270.24  E-value: 9.30e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 174 DAAIARGRADWLVGMNYSRCVTLQAREAGStghVSIGRVQTPVLGLIASRELEIRNFKPVDYLVLtamiavqagkfrakw 253
Cdd:cd00186    5 NAQLARRILDRLVGFNLSRLLTKKLRRKGV---LSAGRVQSPTLGLIVEREREIKAFVPEDYWEI--------------- 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 254 rprngqpgidengrlldaavaamvhqqvagKTGRIAEYRDEQKNENAPLPFSLDELQRLASRRYGMGLEQTLKVVQGLYD 333
Cdd:cd00186   67 ------------------------------KEAVVVSVEKKEKKKNPPPPFTTSTLQQEASSKLGFSAKKTMQIAQKLYE 116

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 334 SKLVTYPRTDCAYLPMSQHAEAAEIVQAvREGFRGTDLPAQLsqldiGRKSRAFDDKRVTAHHGIVPT---PKAANLEAL 410
Cdd:cd00186  117 AGLITYPRTDSTRLSEEAILEAREYIQA-IYGKEYLYPAPLL-----GRRNPKRGKKEQGAHEAIRPTkvaPTPELEANL 190

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 411 SREERLIYEDIARRYLAQFMPPHTYRKVSVRAEVANHDFIASGRTTLKPGWKELYGKaeqaadddaapQDKGDDVNLPAM 490
Cdd:cd00186  191 SEDEFKLYELIWRRFLASQMADAKYEETTVTLEIGGEKFKASGKVLLEDGWLEVYPE-----------EKDDEEEEPPPL 259

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 491 RQDEAARCEGLDRENKKTEPPSRFTDDTLLEAMvnihkyvttpqvKAHfvamlkkseagaddqaqgcGIGTPATRHTFAP 570
Cdd:cd00186  260 KEGDELKLEEVELEEKETQPPPRYTEASLIKLM------------EKR-------------------GIGRPSTYASIIE 308

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 571 KLIEIGVVEhiagkKKAKFFAPTAAGLALYEALPR---SLTVPDATAVWDMAFAKIEAGEITLEQFMafqaRQINAMLAE 647
Cdd:cd00186  309 TLLDRGYVE-----KEKKKLIPTELGFAVIELLEKhfpELVDPEFTAKLEEKLDEIAEGKKDYQEVL----EEFYEEFKK 379


                 .
gi 499665014 648 I 648
Cdd:cd00186  380 I 380
PRK14724 PRK14724
DNA topoisomerase III; Provisional
 6-644 7.58e-71

DNA topoisomerase III; Provisional


Pssm-ID: 237803 [Multi-domain]  Cd Length: 987  Bit Score: 249.87  E-value: 7.58e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014   6 LYVAEKPSVGKALAGHLAKSAPAVGRSGSHIEGSNWAVCWLRGHVYQLAEPDYYiertypEAKRGAngrfpWLFDHLPLL 85
Cdd:PRK14724   4 LVIAEKPSVAQDIVRALTPVAGKFEKHDEHFESDSYVVTSAVGHLVEIQAPEEF------DVKRGK-----WSFANLPVI 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014  86 PANdeWRLVPVSDKAEMIDAVRKLLTRATV--VVHAGDIDREGQL---LVDEVLEDLRCRV--PVKRVLPKAIDDVSVQR 158
Cdd:PRK14724  73 PPY--FDLKPVDKTKTRLNAVVKLAKRKDVteLVNACDAGREGELifrLIEQYAGGAKGGLgkPVKRLWLQSMTPQAIRD 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 159 VLADERDNRDFARMRDAAIARGRADWLVGMNYSRCVTLQAREAGSTGHVSIGRVQTPVLGLIASRELEIRNFKPVDYLVL 238
Cdd:PRK14724 151 GFDNLRSDAQMQGLASAARSRSEADWLVGINGTRAMTAFNSRDGGFFLTTVGRVQTPTLSLVVEREEKIRKFVSRDYWEI 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 239 TAMIAVQAGKFRAKW-RPRNGQPGIDENG---RLLDAAVAAMVHQQVAGKTGRIAEyRDEQKNENAPLPFSLDELQRLAS 314
Cdd:PRK14724 231 HAGFHAEAGEYLGKWfDPQWKKASDDPEAradRVWSEREARAIADAVRGKAATVTE-ESKPTTQASPLLFDLTSLQREAN 309

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 315 RRYGMGLEQTLKVVQGLYDS-KLVTYPRTDCAYLPMSQHAEAAEIVQAVREGFRGTDLPAQLSQLD---IGRKSRAFDDK 390
Cdd:PRK14724 310 GKFGFSAKTTLALAQSLYERhKALTYPRTDSRALPEDYLPVAKQTFEMLATSGMRHLAPFAQQALDgnyVRPSKRIFDNS 389

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 391 RVTAHHGIVPTPKAANleALSREERLIYEDIARRYLAQFMPPHTYRKVSVRAEVANHDFIASGRTTLKPGWKELYGKAEQ 470
Cdd:PRK14724 390 KVSDHFAIIPTTQAPS--GLSEAEQKLYDLVVRRFMAVFFPSAEYQVTTRISQVVGHSFKTEGKVLVKPGWLAIYGKEAA 467

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 471 AADDDAAPQDKGDdvNLPAMRQDEAARCEGLDRENKKTEPPSRFTDDTLLEAMVNIHKYVTTPQVKAhfvAMLKKseaga 550
Cdd:PRK14724 468 NEVEDAKDGDKGQ--PLVPVKPGEMVRTEFAEAKGLKTKPPARYSEATLLGAMESAGKQIDDDELRE---AMQEK----- 537

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 551 ddqaqgcGIGTPATRHTfapkLIEiGVVEHIAGKKKAKFFAPTAAGLALYEALpRSLTV-----PDATAVWDMAFAKIEA 625
Cdd:PRK14724 538 -------GLGTPATRAA----IIE-GLLTEKYMLREGRELIPTAKAFQLMTLL-RGLGVeelsrAELTGEWEYKLAQMEK 604

                        650
                 ....*....|....*....
gi 499665014 626 GEITLEQFMAfqarQINAM 644
Cdd:PRK14724 605 GQLSREAFMQ----QIAAM 619
TOP1Ac smart00437
Bacterial DNA topoisomerase I DNA-binding domain; Bacterial DNA topoisomerase I and III, ...
 292-599 2.14e-59

Bacterial DNA topoisomerase I DNA-binding domain; Bacterial DNA topoisomerase I and III, Eukaryotic DNA topoisomeraes III, reverse gyrase alpha subunit


Pssm-ID: 214663 [Multi-domain]  Cd Length: 259  Bit Score: 201.32  E-value: 2.14e-59
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014   292 RDEQKNENAPLPFSLDELQRLASRRYGMGLEQTLKVVQGLYDSKLVTYPRTDCAYLPMSQHAEAAEIVQAVReGFRGTDL 371
Cdd:smart00437   1 EEKEKKKNPPPPFTTSTLQQEASRKLGFSAKKTMQIAQKLYEKGLITYPRTDSTRLSEEAVLEARNYIQKLY-GKEYLDL 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014   372 PAQLSQldigRKSRAFDDKRVTAHHGIVPT---PKAANLEALSREERLIYEDIARRYLAQFMPPHTYRKVSVRAEVANHD 448
Cdd:smart00437  80 AVVLLK----PRKPRKGKKAQGAHEAIRPTkpiFTPELEKELSEDEFKLYELIWRRFLASQMPDAKYEETKVTIKIGGEK 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014   449 FIASGRTTLKPGWKELYGKAEqaadddaapqdKGDDVNLPAMRQDEAARCEGLDRENKKTEPPSRFTDDTLLEAMvnihk 528
Cdd:smart00437 156 FKAKGKTLLFDGWLKVYPEEK-----------KEEEIELPTLKKGDELKVEEVEVEEKETKPPARYTEASLIKLM----- 219

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 499665014   529 yvttpqvkahfvamlKKSeagaddqaqgcGIGTPATRHTFAPKLIEIGVVEhiagkKKAKFFAPTAAGLAL 599
Cdd:smart00437 220 ---------------EKR-----------GIGRPSTYASIIETLLDRGYVT-----KKKKKLIPTELGIAV 259
PRK07220 PRK07220
DNA topoisomerase I; Validated
 6-722 3.16e-48

DNA topoisomerase I; Validated


Pssm-ID: 180892 [Multi-domain]  Cd Length: 740  Bit Score: 181.88  E-value: 3.16e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014   6 LYVAEKPSVGKALAGHLAKSAPAVGR-SGSHI-----EGSNWAVCWLRGHVYQLAEPDYYIERTYPEAKRgangrfpwlf 79
Cdd:PRK07220   3 LIITEKNIAARRIAQILAPKKPKKTRvSGVDVyryedNGDDTVVVGLSGHIVNIDFPKEYNNWQKVDARD---------- 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014  80 dhlpLLPANDEWRlvPVSDKaeMIDAVRKLLTRATVVVHAGDIDREGQLLVDEVL---EDLRCRVPVKRVLPKAIDDVSV 156
Cdd:PRK07220  73 ----LIDAEIITT--PTQKK--IVTALKKLGKEADRVTIATDYDREGELIGVEALniiKKVNPDIKFDRVRYSAITKKEI 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 157 QRVLADeRDNRDFaRMRDAAIARGRADWLVGMNYSRCVTLQAREAGSTgHVSIGRVQTPVLGLIASRELEIRNFKPVDYL 236
Cdd:PRK07220 145 ERAFSN-PVEVDF-NLADAGHSRQVIDLVWGAALTRYISLAAGRLGKM-FLSVGRVQSPTLALIVDREKEREAFVPTPYW 221

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 237 VLTAMIAVQAGKFRAKwrprngqpgiDENGRLLDAAVAAMVHQQVaGKTGRIAEYRDEQKNENAPLPFSLDELQRLASrR 316
Cdd:PRK07220 222 EIYATLENNGETFVAQ----------HSTRRFWEKEEADRVFEKL-GKTAEVTEVEKGTKTDKPPTPFNTTEFISAAN-S 289

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 317 YGMGLEQTLKVVQGLYDSKLVTYPRTDCAYLPMSqhAEAAEIVQAVREGFRGTDLPAQLSQLDI----GRKSrafddkrV 392
Cdd:PRK07220 290 IGFSAANAMRIAESLYTNGYISYPRTDNTVYPES--LDLREQIEIFAEGPFGEYAQKLLEKGELvptrGKKE-------T 360

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 393 TAHHGIVPTPKAANLEaLSREERLIYEDIARRYLAQFMPPHTYRKVSVRAEVANHDFIASGRTTLKPGWKEL--YGKAEq 470
Cdd:PRK07220 361 TDHPPIYPASLAKKSE-LKEDEWKVYELVVRRFFATFAGPAEWETMKLRFDIGGEEFRANGSRLTEPGWRWYypYNAPE- 438

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 471 aadddaapqdkgdDVNLPAMRQDEAARCEGLDRENKKTEPPSRFTDDTLLEAMVNIhkyvttpqvkahfvamlkkseaga 550
Cdd:PRK07220 439 -------------DRLLPELSEGEELKVKKKEMLDKETQPPGRYGQGRLIKLMEDL------------------------ 481

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 551 ddqaqgcGIGTPATRHTFAPKLIEIGvveHIAGKKkakfFAPTAAGLALYEALPR---SLTVPDATAVWDMAFAKIEAGE 627
Cdd:PRK07220 482 -------GLGTKATRHEIISKLYSRA---YIHGNP----IQPTNTAFAVVDALEKyapTITKPDMTSRLEEDMDKIAEGK 547

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 628 ITLEqfmafqarqinAMLAEIRQ-LRIVLPDLGPRR--VPPTKTAGKRKTASKGgkkanggsgaPCEKCAKGTMQLRNSS 704
Cdd:PRK07220 548 IKED-----------AVLEESREmLEQVFDELDKNRekIRESLREGLREDKIIG----------KCPLCGSDLMVRRSKR 606

                        730
                 ....*....|....*...
gi 499665014 705 RGPFYGCSNFPVCKHTAP 722
Cdd:PRK07220 607 GSRFIGCEGYPECTFSLP 624
PRK05776 PRK05776
DNA topoisomerase I; Provisional
 6-615 1.70e-46

DNA topoisomerase I; Provisional


Pssm-ID: 235602 [Multi-domain]  Cd Length: 670  Bit Score: 175.95  E-value: 1.70e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014   6 LYVAEKPSVGKALAGHLAKSaPAVGRSGS------HIEGSNWAVCWLRGHVYQLAePDyyiERTYPeakrgangrfpwLF 79
Cdd:PRK05776   4 LVIAEKPKAARKIAEALSEK-PIRCRIYGvpywivKRDGKKIVVAPAAGHLFGLH-TK---SKGFP------------VF 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014  80 DHlpllpandEWRLVPVSDKA-----EMIDAVRKLLTRATVVVHAGDIDREGQL---LVDEVLEDLRcrvPVKRVLPKAi 151
Cdd:PRK05776  67 DY--------EWKPLYEIDKGskytkKYYELLSSLSKYADEFINACDYDIEGSVigyLIIKYLGDPK---KAKRMKFSA- 134

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 152 ddvsvqrvLADERDNRDFAR-------MRDAAIARGRADWLVGMNYSRCVTLQAREAgsTGH---VSIGRVQTPVLGLIA 221
Cdd:PRK05776 135 --------LTKSDIRRAFRNletldyeMINAGIARHELDWLWGINVSRALMSSVRDA--SGKrviLSAGRVQSPTLKYVV 204

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 222 SRELEIRNFKPVDYLVLTAMIAVQAGKFRAKwrPRNGQPGIDENGRlldaavaAMVHQQVAGKTGRIAEYRDEQKNENAP 301
Cdd:PRK05776 205 EREIERNLFVPLPYFSVSIIIEKNGYEFTLK--YENKKFETKEEAK-------EILEEIKKTGYLKVTKVEVKIEILEPP 275

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 302 LPFSLDELQRLASRRYGMGLEQTLKVVQGLYDSKLVTYPRTDCAYLP-----------MSQHAEAAEIVQAVREGFRGTD 370
Cdd:PRK05776 276 PPFNLGDLQVEAARIYGFSPYKTQSIAEDLYLDGLISYPRTNSQKLPptlnirnilkgLSRSPQYRPLVNLLLKETKGVL 355

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 371 LPAQlsqldiGRKsrafDDKrvtAHHGIVPT---PKAanleaLSREERLIYEDIARRYLAQFMPPHTYRKVSVRAEVANH 447
Cdd:PRK05776 356 KPVQ------GPK----DDP---AHPAIYPTgepPKN-----LSKDEFKLYDLIVRRFLASFAAPAVLSNTIVTLRVPGF 417

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 448 D--FIASGRTTLKPGWKELYgkaeqaadddaaPQDKGDDVNLPAMRQDEAARCEGLDRENKKTEPPSRFTDdtlleamvn 525
Cdd:PRK05776 418 PlvFSASGQRIEERGWLKYY------------PFHKFDEEELPLLKKGERVKIVDVKVRKSYTKPPSRYSK--------- 476

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 526 ihkyvttpqvkahfVAMLKKSEAgaddqaqgCGIGTPATRHTFAPKLIEIGVVEhiAGKKKAKffaPTAAGLALYEALpr 605
Cdd:PRK05776 477 --------------ASLLKWMES--------VGIGTEATRARIIETLFKRGYLT--SNGKYIE---VTPLGFGVAEVL-- 527

                        650
                 ....*....|
gi 499665014 606 SLTVPDATAV 615
Cdd:PRK05776 528 EKYFPDIVSV 537
PRK06599 PRK06599
DNA topoisomerase I; Validated
 96-722 1.16e-40

DNA topoisomerase I; Validated


Pssm-ID: 235840 [Multi-domain]  Cd Length: 675  Bit Score: 158.87  E-value: 1.16e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014  96 VSDKAEMIDAVRKLLTRATVVVHAGDIDREGQL----LVDEVLEDLRCRVPVKRVLPKAIDDVSVQRVLADERD-NRDfa 170
Cdd:PRK06599  57 IEGKEKVVDALKKAAKKADAVYLATDPDREGEAiawhIAEVLKEAKLKDKNVKRVVFNEITKKAVQEAIENPRDiDMD-- 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 171 rMRDAAIARgRA-DWLVGMNYS--------RCVtlqareagstghvSIGRVQTPVLGLIASRELEIRNFKPVDYLVLTAM 241
Cdd:PRK06599 135 -LVDAQQAR-RAlDYLVGFKLSpllwkkvrRGL-------------SAGRVQSVALRLICEREDEIEAFIPQEYWTIEAD 199

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 242 IAVQAGK-FRAKWRPRNGQPGidENGRLLDAAVAAMVHQQVAGKTGRIAEYRDEQKNENAPLPFSLDELQRLASRRYGMG 320
Cdd:PRK06599 200 LATSNGEpFTAKLVEVNGKKL--EKFSITNEEQAKALVKALEGQAYTVDKIEKKERKRNPPPPFITSTLQQEASRKLGFS 277

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 321 LEQTLKVVQGLYDS--------KLVTYPRTDCAYLpmsqhaeAAEIVQAVREgfrgtDLPAQLSQLDIGRKSRAFDDKRV 392
Cdd:PRK06599 278 AKKTMRIAQKLYEGidlgegtvGLITYMRTDSVRL-------SNEALDEARK-----YITKKYGKEYLPAKPRVYKKKSK 345

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 393 T---AHHGIVPTpkAANL------EALSREERLIYEDIARRYLAQFMPPHTYRKVSVRAEVANHDFI--ASGRTTLKPGW 461
Cdd:PRK06599 346 NaqeAHEAIRPT--SINRtpeslkPYLTPDQFKLYELIWKRTVASQMAPAILDQTSVDIASENGKYVfrATGSVILFPGF 423

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 462 KELYGKAEqaadddaAPQDKGDDVNLPAMRQDEAARCEGLDRENKKTEPPSRFTDDTLLEAMVNIhkyvttpqvkahfva 541
Cdd:PRK06599 424 LKVYGESK-------DDEEEDDEKLLPPLKEGEKLKLDELLPEQHFTEPPPRYSEASLVKKLEEY--------------- 481

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 542 mlkkseagaddqaqgcGIGTPATRHTFAPKLIEIGVVEhIAGKKkakfFAPTAAG----LALYEALPRSLTVpDATAVWD 617
Cdd:PRK06599 482 ----------------GIGRPSTYASIISTLQDREYVE-LEKKR----FIPTDLGrivnDFLVEHFPKYVDY-DFTAGLE 539

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 618 MAFAKIEAGEITLEQFMAFQARQINAMLAEIRQlrivlpdlgprrVPPTKTAGKRKTASKggkkanggsgapCEKCAKGT 697
Cdd:PRK06599 540 DELDEIAEGKKDWKPVLREFWEPFISNLEKVEE------------DVRTEKVTQEETDET------------CPKCGGGP 595

                        650       660
                 ....*....|....*....|....*
gi 499665014 698 MQLRNSSRGPFYGCSNFPVCKHTAP 722
Cdd:PRK06599 596 LVLKLGKNGKFLGCSGYPECKYTKN 620
PRK14973 PRK14973
DNA topoisomerase I; Provisional
 6-718 2.10e-38

DNA topoisomerase I; Provisional


Pssm-ID: 184936 [Multi-domain]  Cd Length: 936  Bit Score: 153.46  E-value: 2.10e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014   6 LYVAEKPSVGKALAGHLA-KSAPAVGRSG--SHIEGSNWAVCWLRGHVYQLA-EPDYYIERTYPEAKRGangrfpwlfdh 81
Cdd:PRK14973   3 LIIAEKNIAANRIAQILAgKTKVQVKKDGgvSTYSFDDTVVVGLRGHVVEVDfEPGYTNWRSEEHTPRS----------- 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014  82 lpLLPAndewRLVPVSDKAEMIDAVRKLLTRATVVVHAGDIDREGQLLVDEVLEDLRC---RVPVKRVLPKAIDDVSVQR 158
Cdd:PRK14973  72 --LIDA----DTIKKPTEKKIVGLIQKLAKKADRVTIATDFDTEGELIGKEAYELVRAvnpKVPIDRARFSAITKEEIVT 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 159 VLADERDnRDFArMRDAAIARGRADWLVGMNYSRCVTLQAREaGSTGHVSIGRVQTPVLGLIASRELEIRNFKPVDYLVL 238
Cdd:PRK14973 146 AFAEPTD-LDFA-LAAAGEARQIIDLIWGASLTRFISLAAHR-GGDNILSVGRVQSPTLAMIVDREKEIEAFVPEKYWML 222

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 239 TAMIAvqagkfrakwrpRNGQPGIDE--NGRLLDAAVAAMVHQQVAGKTgRIAEYRDEQKNENAPLPFSLDELQrLASRR 316
Cdd:PRK14973 223 SLATE------------KDGEGIEARhtHGRFTDSAAAEAAYDATKEPL-VVTEVKEGHKVDRAPTPFDTTTFI-VAASR 288

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 317 YGMGLEQTLKVVQGLYDSKLVTYPRTDCAYLPMSQHaeaaeiVQAVREGFRGTDLPAQLSQLDIGRKSRAFDDKR-VTAH 395
Cdd:PRK14973 289 LGFSAANAMRIAEDLYMNGYISYPRTDNTIYPKSLD------LNGVLATLAKGAFSKDVAWVKDNRRPVPTRGKKsSTDH 362

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 396 HGIVPTpKAANLEALSREERLIYEDIARRYLAQFMPPHTYRKVSVRAEVANHDFIASGRTTLKPGWKELYGKAEqaaddd 475
Cdd:PRK14973 363 PPIHPT-GVATREELGDDRWKLYELVVRRFLATLSPDAEWATMKVNFDAGGEPYTATGGRLLEAGWRTVYPYSE------ 435

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 476 aapqdkGDDVNLPAMRQDEAARCEGLDRENKKTEPPSRFTDDTLLEAMVNIhkyvttpqvkahfvamlkkseagaddqaq 555
Cdd:PRK14973 436 ------AKENILPAFALGEKLPILAVNLEEKETQPPARYSQSRLIQRMEEL----------------------------- 480

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 556 gcGIGTPATRHTFAPKLIEIGVVEhiagkkkAKFFAPTAAGLALYEALPR---SLTVPDATAVWDMAFAKIEAGEitleq 632
Cdd:PRK14973 481 --GLGTKSTRHEVIGKLVSRKYIE-------GNPLRPTLVGRAVTESLEEhagTITEPDMTQTLEEHMQQIKERK----- 546

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 633 fmafqaRQINAMLAEIRQ-LRIVLPDLgprrvPPTKTAGKRKTASKGGKKANGGsgaPCEKCAKgTMQLRNSSRGPFYGC 711
Cdd:PRK14973 547 ------RTRDDVVTESRKmLHRAFDEL-----EANEAVIGRDIMERTAEELTIG---PCPVCGK-DLRIKHIGSSQFIGC 611


                 ....*..
gi 499665014 712 SNFPVCK 718
Cdd:PRK14973 612 SGYPDCT 618
PRK07561 PRK07561
DNA topoisomerase I subunit omega; Validated
 97-722 4.54e-37

DNA topoisomerase I subunit omega; Validated


Pssm-ID: 236048 [Multi-domain]  Cd Length: 859  Bit Score: 149.17  E-value: 4.54e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014  97 SDKAEMIDAVRKLLTRATVVVHAGDIDREGQ-----LLvdEVLEDLRcrVPVKRVLPKAIDDVSVQRVLADERD-NRDfa 170
Cdd:PRK07561  71 PGKEKVVSELKKAAKDADELYLATDPDREGEaiawhLL--EVLGGDD--VPVKRVVFNEITKNAIQEAFENPRElDIN-- 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 171 rMRDAAIARgRA-DWLVGMNYS----RCVtlqareAGStghVSIGRVQTPVLGLIASRELEIRNFKPVDYLVLTAMIAVQ 245
Cdd:PRK07561 145 -LVNAQQAR-RFlDRLVGYMVSpllwKKI------ARG---LSAGRVQSVAVRLIVEREREIEAFVPEEYWDIHADLTTP 213

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 246 AG-KFRAKWRPRNGQPGidENGRLLDAAVAAMVHQQVAGKTGRIAEYRDEQKNENAPLPFSLDELQRLASRRYGMGLEQT 324
Cdd:PRK07561 214 RGdAFEARLTHLDGKKF--APVDLLNEAQAEAAVAALEGARYSVASVEDKPTTRKPSAPFTTSTLQQEASRKLGFSVKKT 291

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 325 LKVVQGLYDSKLVTYPRTDCAYLpmsqhaeAAEIVQAVR---EGFRGTD-LPAQLSQLdiGRKSR-AFDdkrvtAHHGIV 399
Cdd:PRK07561 292 MRIAQRLYEAGYITYMRTDSTNL-------SQEAINAARgyiGDNYGKKyLPEKPRQY--SSKAKnAQE-----AHEAIR 357

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 400 PTP---KAANLEALSREERLIYEDIARRYLAQFMPPHTYRKVSVRAEVANHDFIASGRTTLKPGWKELY--GKAEQAAdd 474
Cdd:PRK07561 358 PSDvfrTPDQLKGLEGDAQRLYELIWKRFVASQMAPARYDSTTVTIAAGDAELRATGRVLRFDGFLKVYveGRDDALD-- 435

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 475 daapqdkGDDVNLPAMRQDEAARCEGLDRENKKTEPPSRFTDDTLleamvnihkyvttpqVKahfvAMLKKseagaddqa 554
Cdd:PRK07561 436 -------DEDRRLPALKVGDALTLEKLDPTQHFTKPPARYSEASL---------------VK----ELEKL--------- 480

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 555 qgcGIGTPATRHTFAPKLIEIGVVehiagKKKAKFFAPTAAGLA----LYEALPRsLTVPDATAvwDM--AFAKIEAGEI 628
Cdd:PRK07561 481 ---GIGRPSTYASIISTIQDRGYV-----RLENRRFYPEKMGRIvtdrLEEFFPR-LVDYDFTA--RMeeELDDIANGEA 549

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 629 ----TLEQFMafqaRQINAMLAEIRQLRivlpdlgprrvpptktagkrktaSKGGKKANGGSGAP--CEKCAKGtMQLRN 702
Cdd:PRK07561 550 dwkpVLDDFY----KDFSQQLEKAEELR-----------------------EEGGMRPNQMVITDrdCPTCGRG-MGIRT 601

                        650       660
                 ....*....|....*....|...
gi 499665014 703 SSRGPFYGCSNFPV---CKHTAP 722
Cdd:PRK07561 602 GKTGVFLGCSGYALkerCKTTRN 624
TOPRIM_TopoIA_TopoIII cd03362
TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type ...
 5-162 5.84e-37

TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving one strand of the DNA duplex, covalently linking to the 5' phosphoryl end of the DNA break and, allowing the other strand of the duplex to pass through the gap. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). For topoisomerases the conserved glutamate is believed to act as a general base in strand joining and, as a general acid in strand cleavage. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.


Pssm-ID: 173782 [Multi-domain]  Cd Length: 151  Bit Score: 135.44  E-value: 5.84e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014   5 KLYVAEKPSVGKALAGHLAKSAPAVGRS---GSHIEGSNWAVCWLRGHVYQLAEPDYYIERTYpeakrgangrfPWLFDH 81
Cdd:cd03362    2 VLIIAEKPSVAKAIAKILGGGSKKKGKGryyEFYGEGGGYVVTWASGHLLELDFPEEYDPWDK-----------VWPLED 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014  82 lPLLPAndEWRLVPVSDKAEMIDAVRKLLTRATVVVHAGDIDREGQLLVDEVLEDLRC--RVPVKRVLPKAIDDVSVQRV 159
Cdd:cd03362   71 -PLFPA--PFKLKVDKGKKKQFKVLKKLAKRADEIVIATDADREGELIGREILEYAKCvkRKPVKRAWFSSLTPKAIRRA 147


                 ...
gi 499665014 160 LAD 162
Cdd:cd03362  148 FKN 150
PRK08780 PRK08780
DNA topoisomerase I; Provisional
 103-523 2.42e-35

DNA topoisomerase I; Provisional


Pssm-ID: 181555 [Multi-domain]  Cd Length: 780  Bit Score: 143.36  E-value: 2.42e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 103 IDAVRKLLTRATVVVHAGDIDREGQLLVDEVLEDLRCR-----VPVKRVLPKAIDDVSVQRVLADERDNRdfARMRDAAI 177
Cdd:PRK08780  64 VEAIAKAAKSADDLYLATDPDREGEAISWHLAEILKERgllkdKPMQRVVFTEITPRAIKEAMAKPRDIA--SDLVDAQQ 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 178 ARGRADWLVGMNYSRCVTLQAREAgstghVSIGRVQTPVLGLIASRELEIRNFKPVDYLVLTAMIAVQAGKFRAKWRPRN 257
Cdd:PRK08780 142 ARRALDYLVGFNLSPLLWRKIQRG-----LSAGRVQSPALRMIVEREEEIEAFIAREYWSIEADCAHPSQPFNAKLIKLD 216

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 258 GQP----GIDENGRlldAAVAAMVHQQVAGKTGRIAEYRDEQKNENAPLPFSLDELQRLASRRYGMGLEQTLKVVQGLYD 333
Cdd:PRK08780 217 GQKfeqfTITDGDT---AEAARLRIQQAAQGTLHVTDVESKERKRNPAPPFTTSTLQQEASRKLGFTTRRTMQVAQKLYE 293

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 334 S---------KLVTYPRTDCAYLpmSQHAeAAEIVQAVREGFRGTDLPAQLSQLdigrKSRAFDDKRvtAHHGIVPTPKA 404
Cdd:PRK08780 294 GvdlgdegsvGLITYMRTDSVNL--SQDA-LAEIRDVIARDYGTASLPDQPNTY----KTKSKNAQE--AHEAVRPTSAL 364

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 405 ANLEA----LSREERLIYEDIARRYLAQFMPPHTYRKVSVR-AEVANHDFIASGRTTLKPGWKELYGKAEQAADDDAAPQ 479
Cdd:PRK08780 365 RTPAQvarfLSDDQRRLYELIWKRAVACQMIPATLNTVSVDlAAGSEHVFRATGSTVVVPGFLAVYEEGKDDKSAEDEDE 444

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....
gi 499665014 480 DKgddvNLPAMRQDEAARCEGLDRENKKTEPPSRFTDDTLLEAM 523
Cdd:PRK08780 445 GR----KLPPMKEGDNVPLERIRAEQHFTEPPPRYTEASLVKAL 484
TOPRIM_TopoIA cd01028
TOPRIM_TopoIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the ...
 5-161 5.15e-31

TOPRIM_TopoIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in the type IA family of DNA topoisomerases (TopoIA). This subgroup contains proteins similar to the Type I DNA topoisomerases: E. coli topisomerases I and III, eukaryotic topoisomerase III and, ATP-dependent reverse gyrase found in archaea and thermophilic bacteria. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA. These enzymes cleave one strand of the DNA duplex, covalently link to the 5' phosphoryl end of the DNA break and allow the other strand of the duplex to pass through the gap. Reverse gyrase is also able to insert positive supercoils in the presence of ATP and negative supercoils in the presence of AMPPNP. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). For topoisomerases the conserved glutamate is believed to act as a general base in strand joining and, as a general acid in strand cleavage. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.


Pssm-ID: 173778 [Multi-domain]  Cd Length: 142  Bit Score: 118.48  E-value: 5.15e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014   5 KLYVAEKPSVGKALAGHLAKSAPavgRSGSHIEGSNWAVCWLRGHVYQLAEPDYYIERTYPEakrgangrfpwlfdhlPL 84
Cdd:cd01028    2 VLIIAEKPSKAKTIAKILGKGSK---KKGFYGEGGGYVVTASVGHLLELPFPEEYVDWDKDW----------------PL 62

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 499665014  85 LPANDEWRLVPVSDKAEMIDAVRKLLTRATVVVHAGDIDREGQLLVDEVLEDLRC-RVPVKRVLPKAIDDVSVQRVLA 161
Cdd:cd01028   63 ELFPFEPKYVVIPDKKKQLKALKKLAKKADEIVLATDPDREGELIAWEILEVLKCdNKPVKRAWFSEITPKAIREAFK 140
PRK06319 PRK06319
DNA topoisomerase I/SWI domain fusion protein; Validated
 98-727 1.06e-26

DNA topoisomerase I/SWI domain fusion protein; Validated


Pssm-ID: 235778 [Multi-domain]  Cd Length: 860  Bit Score: 116.46  E-value: 1.06e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014  98 DKAEMIDAVRKLLTRATVVVHAGDIDREGQLLVDEVLEDLRCRVPVKRVLPKAIDDVSVQRVLADERDnRDFArMRDAAI 177
Cdd:PRK06319  59 DKEEVINKICKLAKKCDVVYLSPDPDREGEAIAWHIANQLPKNTKIQRISFNAITKGAVTEALKHPRE-IDMA-LVNAQQ 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 178 ARGRADWLVGMNYSrcvTLQAREAGSTGHVSIGRVQTPVLGLIASRELEIRNFKPVDYLVLTAMIavQAGK----FRAKW 253
Cdd:PRK06319 137 ARRLLDRIVGYKIS---PILSRKLQRRSGVSAGRVQSVALKLVVDREKAIEAFVPVEYWNIRVHL--KDPKtqktFWAHL 211

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 254 RPRNGQ-------PGIDENGRLL--DAAVAAMVHQQVAGKTGRIAEYRDEQKNENAPLPFSLDELQRLASRRYGMGLEQT 324
Cdd:PRK06319 212 YSVDGKkwekeipEGKTEDEVLLinSKEKADHIVELLESATYTVTRVESKEKRRNAYPPFITSTLQQEASRHFRFSSSRT 291

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 325 LKVVQGLY-----DSK----LVTYPRTDCAYLpmsqhaeAAEIVQAVREGFRGTdlpaqLSQLDIGRKSRAFDDKRVT-- 393
Cdd:PRK06319 292 MNIAQTLYegvdlDSEgatgLITYMRTDSVRT-------DPEALKQVRKYIEGT-----FGKEFLPSSPNVYTTKKMAqd 359

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 394 AHHGIVPTPKAANLEA----LSREERLIYEDIARRYLAQFMPPHTYRKVSVRAEVANH-DFIASGRTTLKPGWKELYGKA 468
Cdd:PRK06319 360 AHEAIRPTDITLTPEKlrskLTEDQYKLYSLIWKRFVASQMIPAIYDTLAIRITTNKGiDLRATGSLLKFKGFLAVYEEK 439

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 469 EQAADDDAapqdkgDDVNLPAMRQDEAARCEGLDRENKKTEPPSRFTDdtlleamvnihkyvttpqvkAHFVAMLKKSea 548
Cdd:PRK06319 440 RDDEGDEE------ENIHLPKLHEQDVLTKEELSAEQAFTKPLPRFTE--------------------ASLVKELEKS-- 491

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 549 gaddqaqgcGIGTPATRHTFAPKlieIGVVEHIAgkKKAKFFAPTAAGLALYEAL----PRsltvpdataVWDMAFAKIE 624
Cdd:PRK06319 492 ---------GIGRPSTYATIMNK---IQSREYTL--KENQRLRPTELGKIISQFLetnfPR---------IMDIGFTALM 548

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 625 AGEITLeqfmafqarqinamLAE-IRQLRIVLPDLGPRRVPPTKTAGKRKTASKGGKKANggsgapCEKCAKGTMQLRNS 703
Cdd:PRK06319 549 EDELEL--------------IADnKKPWKLLLQEFWELFLPVVVTAEKEAFIPRIVTEID------CPKCHKGKLVKIWA 608

                        650       660
                 ....*....|....*....|....
gi 499665014 704 SRGPFYGCSNFPVCKHTAPADSAA 727
Cdd:PRK06319 609 KNRYFYGCSEYPECDYKTSEEELT 632
YrdD COG0551
DNA topoisomerase I, ssDNA-binding Zn-finger and Zn-ribbon domains [Replication, recombination ...
 57-722 5.53e-19

DNA topoisomerase I, ssDNA-binding Zn-finger and Zn-ribbon domains [Replication, recombination and repair];


Pssm-ID: 440317 [Multi-domain]  Cd Length: 695  Bit Score: 91.46  E-value: 5.53e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014  57 DYYIERTYPEAKRGANGRFPWLFDHLPLLPANDEWRLVPVSDKAEMIDAVRKLLTRATVVVHAGDIDREGQLLVDEVLED 136
Cdd:COG0551   31 KKGLAGALGLKKKLVDLLLKEKLKKLVENEKLIAELDIKDLKKLKKDKKKKAKALAAALAAADDDAIEAAAAADEEEALK 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 137 LRCRVPVKRVLPKAIDDVSVQRVLADERDNRDFARMRDAAIARGRADWLvgmnysrcvtLQAREAGSTGHVSIGRVQTPV 216
Cdd:COG0551  111 AAEALEAIRKAVVEEVKSRARKRAARAPADVAAAAAAAALARLLLLAAA----------SRALRLLLLLAAGRLRLLSAV 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 217 LGLIASRELEIRNFKPVDYLVLTAMIAVQAGKFRAKWRPRNGQPGIDENGRllDAAVAAMVHQQVAGKTGRIAEYRDEQK 296
Cdd:COG0551  181 AAGLLELEELLKEFEEEEEEEAAEEEEEEEEAKKKKEEDKKKKKKKKKKDK--EEETKAIKKKKKAAEAVLAAKKAAKEA 258

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 297 NENAPLPFSLDELQRLA----SRRYGMGLEQTLKVVQGLYDSKLVTYPRTDCAYLPMSQHAEAAEIVQAVREGFRGTDLP 372
Cdd:COG0551  259 KAKKELPTTTTDALPEAlattSLTAAAAASALAAALLEEEGELLYTGGYIRYTRTPKSSEADALAALEALKKIAEEPPDE 338

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 373 AQLSQLDIGRKSRAFDDKRVTAHHGIVPTPKAANLEALSREERLIYEDIARRYLAQFMPPHTYRKVSVRAEVANHDFIAS 452
Cdd:COG0551  339 RAKKKKKKAKKKKASEAKETTDHPPIPPTTAAALLELLEDRKLLLELLVRRRFAAAADLAKVEELTKVEEADEEELVEAE 418

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 453 GRTTLKPGWKELYGKAEQaadddaapqdkgDDVNLPAMRQDEAARCEGLDRENKKTEPPSRFTDDTLLeamvnihkyvtt 532
Cdd:COG0551  419 GGLLEVLGEEEEDDEDEE------------EELLLPPLEEGEPLLLEELLLEKQTTTPPPRYTTELLL------------ 474

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 533 pqvkahfVAMLKKseagaddqaqgcGIGTPATRHTFAPKLIEIGVVEHIagKKKAKFFAPTAAGLALYEALPRSLTVPDA 612
Cdd:COG0551  475 -------KKLEEE------------GGGGRGTTATIIILILKRRYVVLE--EKKTTPTELLVEVVLLLLLPFPKLEDTTE 533

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 613 TAVWDMAFAKIEAGEitleqfmafqarqinamlaeiRQLRIVLPDLGPRRVPPTKTAGKRKTASKGGKKANGgSGAPCEK 692
Cdd:COG0551  534 TAEEEEALLDKEEGK---------------------EDKVVEIREEEYPFFKKLLEIAEEEGEEELSEEDEV-LGEKCPK 591

                        650       660       670
                 ....*....|....*....|....*....|
gi 499665014 693 CAKgTMQLRNSSRGPFYGCSNFPVCKHTAP 722
Cdd:COG0551  592 CGK-PLVIKKGRYGKFLGCSNYPECKYTKP 620
TOP1Bc smart00436
Bacterial DNA topoisomeraes I ATP-binding domain; Extension of TOPRIM in Bacterial DNA ...
 174-235 1.04e-16

Bacterial DNA topoisomeraes I ATP-binding domain; Extension of TOPRIM in Bacterial DNA topoisomeraes I and III, Eukaryotic DNA topoisomeraes III, reverse gyrase beta subunit


Pssm-ID: 214662 [Multi-domain]  Cd Length: 89  Bit Score: 75.70  E-value: 1.04e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 499665014   174 DAAIARGRADWLVGMNYSRCVTLQAREAGstghVSIGRVQTPVLGLIASRELEIRNFKPVDY 235
Cdd:smart00436  30 NAQLARRILDRLIGFNLSRLLTKKLRNGV----LSAGRVQTPTLGLIVEREREIKNFVPKPY 87
TopG2 COG1110
Reverse gyrase [Replication, recombination and repair];
95-628 5.59e-16

Reverse gyrase [Replication, recombination and repair];


Pssm-ID: 440727 [Multi-domain]  Cd Length: 1219  Bit Score: 82.33  E-value: 5.59e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014   95 PVSDKAEMIDAVRKLLTRATVVVHAGDIDREGQLLVDEVLEDLRCRVP-VKR-----VLPKAIddvsvqrvLADERDNRD 168
Cdd:COG1110   733 NIVDSLEIVEALRELATEVDEVLIGTDPDTEGEKIGWDVYNLLRPYAKnIKRiefheVTRKAI--------LEALKNPRE 804

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014  169 F-ARMRDAAIARGRADWLVGMNYSRCVTlqarEAGSTGHVSIGRVQTPVLGLIASRELEIRNFKpVDYLVLTAMIAVQAG 247
Cdd:COG1110   805 IdENLVEAQIVRRIEDRWIGFTLSQKLW----KVFGNRNLSAGRVQTPVLGWIIERYEESRKSK-KYLIILTLENGRLEL 879

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014  248 KFRAKWRPRNGQPGIDENGRLldaavaamvhqqvagktgRIAEYRDEQKNENAPLPFSLDELQRLASRRYGMGLEQTLKV 327
Cdd:COG1110   880 SIEDLKEAEEVRKALEKEVKV------------------KVKKVEEEEEELNPLPPYTTDTLLRDASRRLGLSAEETMRL 941

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014  328 VQGLYDSKLVTYPRTDcaylpmSQHAEAAEIVQA---VREGFrGTDLPAQLSQLDIGrksrafddkrvtAHHGIVPTpKA 404
Cdd:COG1110   942 AQDLFESGLITYHRTD------STRVSDAGIAVAkeyISERF-GEEYFKPRRWGEGG------------AHEAIRPT-RP 1001

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014  405 ANLEALSR--EERLI-------------YEDIARRYLAQFMPPHTYRKVSVRAEVANHDF-IASGRTT--LKPGWKELYG 466
Cdd:COG1110  1002 LDAEDLRRliEEGVIelpipltrrhlrlYDLIFRRFMASQMRPAKVEKVKLRVSLELPGGeIEEERIVeiIEDGFLLIYP 1081

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014  467 KAEQAAdddaapqdkgddvNLPamrqdeaarcEGldrenkkteppsrftddtllEAMVNIHKYVTTPQVK----AHFVAM 542
Cdd:COG1110  1082 PIKVEP-------------ELK----------EG--------------------EYKVTEVKIRKVPKVPlytqGDLVRE 1118

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014  543 LKKSeagaddqaqgcGIGTPATRHTFAPKLIEIG-VVEHiagkKKAKFFAPTAAGLALYEALP---RSLTVPDATAVWDM 618
Cdd:COG1110  1119 MKER-----------GIGRPSTYAKIVETLLRRGyVVES----KKGKKLVPTKLGIEVYNYLSenfPDLVSEERTRELEE 1183

                         570
                  ....*....|
gi 499665014  619 AFAKIEAGEI 628
Cdd:COG1110  1184 KMDEIEEGEA 1193
PTZ00407 PTZ00407
DNA topoisomerase IA; Provisional
 90-525 6.99e-14

DNA topoisomerase IA; Provisional


Pssm-ID: 173597 [Multi-domain]  Cd Length: 805  Bit Score: 75.36  E-value: 6.99e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014  90 EWRLVPVSDKAEMIDA-VRKLLTRATVVVHAGDIDREGQLLVDEVLEDLR-----CRVPVKRVLPKAIDDVSVQRVLADE 163
Cdd:PTZ00407 101 EWELLPGRRIQETLERyIEEKADNVTEIILATDPDREGELIAVHALQTIKrlypkLKVPFSRAYMHSITEDGIRKAMRER 180

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 164 RDNRDFARMRDAAIARGRADWLVGMNYSRCVtlqaREAGSTGHvSIGRVQTPVLGLIASRELEIRNF--KPVDYLVLTAM 241
Cdd:PTZ00407 181 HVEACDYDLANAAETRHAMDRIFGFLGSSVV----RAANSQMR-SIGRVQTPALILINEREDKIKAFleSNKSTFEVQAM 255

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 242 IavqagKFRAKWRPRNGQ-----PgiDENGRLLDAAVAAMV----HQQVAGKTGRIAEYRDEQKNENA---PLPFSLDEL 309
Cdd:PTZ00407 256 C-----QFPSPHGTTFSQvvtitP--DRKGGASHWATEAEArrclEQWKLNNCTGFSVPLEPKPQPSVvppPQPFTMATA 328

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 310 QRLASRRYGMGLEQTLKVVQGLYDSKLVTYPRTDCAYLPMSQhaeAAEIVQAVREGF------RGTDLPAQLSQLDIGRK 383
Cdd:PTZ00407 329 IAKANRQLKYSSEMVSGCLQDLFQLGHITYPRTDSTRIDESA---LPDIYAAVKKEFgkeflyRLEDRTVSAQEGKGSKK 405

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 384 SRAfddKRVT---------------AHHGIVPTPKAANLE--ALSREERLIYEDIARRYLAQFMPPHTYRK--VSVRAEV 444
Cdd:PTZ00407 406 TGK---KRSTkqkkgadtpvgnvedAHEAIRPTNIDTTGEslSLSPPTRAVYDLVRRNTLAVFMIPMKTEKivATVKFTS 482

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665014 445 ANHD---FIASGRTTLKPGWKELYGKAEQAADDDAAPQDKGDD------VNLPAMRQDE--------AARCEGLD----- 502
Cdd:PTZ00407 483 GSGEkleFELQGKRVVEPGWTRAFHKGDKGTTGPAEETDEDITaveegaPVVPSLSQEEfkaimnlrSQLGSGVQkgffe 562

                        490       500
                 ....*....|....*....|....*....
gi 499665014 503 ------RENKKTePPSRFTDDTLLEAMVN 525
Cdd:PTZ00407 563 lrspqvRENRPV-PPLPHSEGTLIEELKN 590
zf-C4_Topoisom pfam01396
Topoisomerase DNA binding C4 zinc finger;
690-725 1.25e-07

Topoisomerase DNA binding C4 zinc finger;


Pssm-ID: 307520 [Multi-domain]  Cd Length: 39  Bit Score: 48.41  E-value: 1.25e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 499665014  690 CEKCaKGTMQLRNSSRGPFYGCSNFPVCKHTAPADS 725
Cdd:pfam01396   4 CPKC-GGDLVLKRGRFGKFVGCSNYPECRFTRPLKK 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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