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Conserved domains on  [gi|499665365|ref|WP_011346099|]
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MULTISPECIES: HrpD5 family protein [Xanthomonas]

Protein Classification

FHA domain-containing protein( domain architecture ID 1702)

FHA (forkhead-associated) domain-containing protein participates in signal transduction pathways via protein-protein interactions involving recognition of pThr and pTyr phosphopeptides

Gene Ontology:  GO:0051219
PubMed:  10518219|11069759
SCOP:  4002605

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HrpD5 NF041525
HrpD5 family protein;
2-302 1.22e-118

HrpD5 family protein;


:

Pssm-ID: 469410  Cd Length: 314  Bit Score: 343.88  E-value: 1.22e-118
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665365   2 TMQLRVMTGTHAGARLDLAQGRYTLGSDPQTDIRIDDWPGCSLIIEVDQDGQIRYG-SDTVQETFFVAFQPVRFGPLVLC 80
Cdd:NF041525   1 TKEIRVLTGRHAGARLDLSPGRYTIGADDDADIQISDWTAPPLQLEVDEDGQVRIRrSDAAPAVPLEDFVPRRFGDIVLC 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665365  81 VGDAAADWPDDVALLERLLSPAPPPA--------PRTSRRKVLRTA---VGAVLALAAAALLPSLQPAFLSDAATRQHPE 149
Cdd:NF041525  81 VGPADAAWPSDLELLERLLSPAPAAAaapapravSRARRRRALRAAvgaALVGAALAAAALLPAANPAHASAAAPPPAPE 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665365 150 NTLNQAKALLKQLGFREAHAEQVGTRVLIEGLVPSSADAARLRAQVHRYHPGVAVNV-AVVDEVVATLRDTLADPALTVR 228
Cdd:NF041525 161 PLLAQVRRALARLGLPELRVRQQGDRVLVEGLVASSADAAALRRALDRFAPGRVVWRvAVADEVAQSLRESLGDPGLSVR 240

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 499665365 229 YEGNGVFSVSGSSDYAERASRRIADVRSDLGPEVRALHVEISQQDPSIKPPDNYDAALLADGLHYVETPDGTKH 302
Cdd:NF041525 241 YRGRGVFSVTGVAQHADRVRARLERLRADLGPLVRRIDVDVTRQDPPDAPPANYDSALSVDGLHYVETPDGTKH 314
 
Name Accession Description Interval E-value
HrpD5 NF041525
HrpD5 family protein;
2-302 1.22e-118

HrpD5 family protein;


Pssm-ID: 469410  Cd Length: 314  Bit Score: 343.88  E-value: 1.22e-118
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665365   2 TMQLRVMTGTHAGARLDLAQGRYTLGSDPQTDIRIDDWPGCSLIIEVDQDGQIRYG-SDTVQETFFVAFQPVRFGPLVLC 80
Cdd:NF041525   1 TKEIRVLTGRHAGARLDLSPGRYTIGADDDADIQISDWTAPPLQLEVDEDGQVRIRrSDAAPAVPLEDFVPRRFGDIVLC 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665365  81 VGDAAADWPDDVALLERLLSPAPPPA--------PRTSRRKVLRTA---VGAVLALAAAALLPSLQPAFLSDAATRQHPE 149
Cdd:NF041525  81 VGPADAAWPSDLELLERLLSPAPAAAaapapravSRARRRRALRAAvgaALVGAALAAAALLPAANPAHASAAAPPPAPE 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665365 150 NTLNQAKALLKQLGFREAHAEQVGTRVLIEGLVPSSADAARLRAQVHRYHPGVAVNV-AVVDEVVATLRDTLADPALTVR 228
Cdd:NF041525 161 PLLAQVRRALARLGLPELRVRQQGDRVLVEGLVASSADAAALRRALDRFAPGRVVWRvAVADEVAQSLRESLGDPGLSVR 240

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 499665365 229 YEGNGVFSVSGSSDYAERASRRIADVRSDLGPEVRALHVEISQQDPSIKPPDNYDAALLADGLHYVETPDGTKH 302
Cdd:NF041525 241 YRGRGVFSVTGVAQHADRVRARLERLRADLGPLVRRIDVDVTRQDPPDAPPANYDSALSVDGLHYVETPDGTKH 314
FHA_YscD-like cd22710
forkhead associated (FHA) domain found in Yersinia enterocolitica Yop proteins translocation ...
 5-55 2.62e-06

forkhead associated (FHA) domain found in Yersinia enterocolitica Yop proteins translocation protein D (YscD) and similar proteins; YscD protein is a single-pass inner membrane protein required for the export process of the Yop proteins. It is an essential component of the type III secretion system. YscD protein contains an N-terminal cytoplasmic domain, a transmembrane linker and a large periplasmic domain. The cytoplasmic domain consists of a forkhead-associated (FHA) fold. The FHA domain is a small phosphopeptide recognition module. Due to the lack of the conserved residues that are required for binding phosphothreonine, the cytoplasmic domain of YscD protein is therefore unlikely to function as a true FHA domain.


Pssm-ID: 438762 [Multi-domain]  Cd Length: 94  Bit Score: 45.08  E-value: 2.62e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 499665365   5 LRVMTGTHAGARLDLAQGRYTLGSDP-QTDIRIDDwPGCS---LIIEVDqDGQIR 55
Cdd:cd22710    2 LRILSGNHRGAEVPLPPGRYVLGSDPlQCDLVLTD-SGISpvhLVLEVD-DGGVR 54
Yop-YscD_cpl pfam16697
Inner membrane component of T3SS, cytoplasmic domain; Yop-YscD-cpl is the cytoplasmic domain ...
 6-52 2.92e-06

Inner membrane component of T3SS, cytoplasmic domain; Yop-YscD-cpl is the cytoplasmic domain of Yop proteins like YscD from Proteobacteria. YscD forms part of the inner membrane component of the bacterial type III secretion injectosome apparatus.


Pssm-ID: 465238 [Multi-domain]  Cd Length: 94  Bit Score: 44.94  E-value: 2.92e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 499665365    6 RVMTGTHAGARLDLAQGRYTLGSDPQTDIRIDDwPGCS---LIIEVDQDG 52
Cdd:pfam16697   1 RVLSGPHAGAEFPLEGGRYRIGSDPDCDIVLSD-KEVSrvhLKLEVDDEG 49
FHA COG1716
Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms];
2-52 1.63e-04

Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms];


Pssm-ID: 441322 [Multi-domain]  Cd Length: 96  Bit Score: 39.94  E-value: 1.63e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 499665365   2 TMQLRVMTGTHAGARLDLAQGRYTLGSDPQTDIRIDDwPGCS---LIIEVDQDG 52
Cdd:COG1716    1 MARLVVLEGPLAGRRFPLDGGPLTIGRAPDNDIVLDD-PTVSrrhARIRRDGGG 53
 
Name Accession Description Interval E-value
HrpD5 NF041525
HrpD5 family protein;
2-302 1.22e-118

HrpD5 family protein;


Pssm-ID: 469410  Cd Length: 314  Bit Score: 343.88  E-value: 1.22e-118
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665365   2 TMQLRVMTGTHAGARLDLAQGRYTLGSDPQTDIRIDDWPGCSLIIEVDQDGQIRYG-SDTVQETFFVAFQPVRFGPLVLC 80
Cdd:NF041525   1 TKEIRVLTGRHAGARLDLSPGRYTIGADDDADIQISDWTAPPLQLEVDEDGQVRIRrSDAAPAVPLEDFVPRRFGDIVLC 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665365  81 VGDAAADWPDDVALLERLLSPAPPPA--------PRTSRRKVLRTA---VGAVLALAAAALLPSLQPAFLSDAATRQHPE 149
Cdd:NF041525  81 VGPADAAWPSDLELLERLLSPAPAAAaapapravSRARRRRALRAAvgaALVGAALAAAALLPAANPAHASAAAPPPAPE 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499665365 150 NTLNQAKALLKQLGFREAHAEQVGTRVLIEGLVPSSADAARLRAQVHRYHPGVAVNV-AVVDEVVATLRDTLADPALTVR 228
Cdd:NF041525 161 PLLAQVRRALARLGLPELRVRQQGDRVLVEGLVASSADAAALRRALDRFAPGRVVWRvAVADEVAQSLRESLGDPGLSVR 240

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 499665365 229 YEGNGVFSVSGSSDYAERASRRIADVRSDLGPEVRALHVEISQQDPSIKPPDNYDAALLADGLHYVETPDGTKH 302
Cdd:NF041525 241 YRGRGVFSVTGVAQHADRVRARLERLRADLGPLVRRIDVDVTRQDPPDAPPANYDSALSVDGLHYVETPDGTKH 314
FHA_YscD-like cd22710
forkhead associated (FHA) domain found in Yersinia enterocolitica Yop proteins translocation ...
 5-55 2.62e-06

forkhead associated (FHA) domain found in Yersinia enterocolitica Yop proteins translocation protein D (YscD) and similar proteins; YscD protein is a single-pass inner membrane protein required for the export process of the Yop proteins. It is an essential component of the type III secretion system. YscD protein contains an N-terminal cytoplasmic domain, a transmembrane linker and a large periplasmic domain. The cytoplasmic domain consists of a forkhead-associated (FHA) fold. The FHA domain is a small phosphopeptide recognition module. Due to the lack of the conserved residues that are required for binding phosphothreonine, the cytoplasmic domain of YscD protein is therefore unlikely to function as a true FHA domain.


Pssm-ID: 438762 [Multi-domain]  Cd Length: 94  Bit Score: 45.08  E-value: 2.62e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 499665365   5 LRVMTGTHAGARLDLAQGRYTLGSDP-QTDIRIDDwPGCS---LIIEVDqDGQIR 55
Cdd:cd22710    2 LRILSGNHRGAEVPLPPGRYVLGSDPlQCDLVLTD-SGISpvhLVLEVD-DGGVR 54
Yop-YscD_cpl pfam16697
Inner membrane component of T3SS, cytoplasmic domain; Yop-YscD-cpl is the cytoplasmic domain ...
 6-52 2.92e-06

Inner membrane component of T3SS, cytoplasmic domain; Yop-YscD-cpl is the cytoplasmic domain of Yop proteins like YscD from Proteobacteria. YscD forms part of the inner membrane component of the bacterial type III secretion injectosome apparatus.


Pssm-ID: 465238 [Multi-domain]  Cd Length: 94  Bit Score: 44.94  E-value: 2.92e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 499665365    6 RVMTGTHAGARLDLAQGRYTLGSDPQTDIRIDDwPGCS---LIIEVDQDG 52
Cdd:pfam16697   1 RVLSGPHAGAEFPLEGGRYRIGSDPDCDIVLSD-KEVSrvhLKLEVDDEG 49
FHA COG1716
Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms];
2-52 1.63e-04

Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms];


Pssm-ID: 441322 [Multi-domain]  Cd Length: 96  Bit Score: 39.94  E-value: 1.63e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 499665365   2 TMQLRVMTGTHAGARLDLAQGRYTLGSDPQTDIRIDDwPGCS---LIIEVDQDG 52
Cdd:COG1716    1 MARLVVLEGPLAGRRFPLDGGPLTIGRAPDNDIVLDD-PTVSrrhARIRRDGGG 53
FHA cd00060
forkhead associated (FHA) domain superfamily; Forkhead-associated (FHA) domains are small ...
 5-52 2.50e-04

forkhead associated (FHA) domain superfamily; Forkhead-associated (FHA) domains are small phosphopeptide recognition modules mostly found in eubacteria and eukaryotes. It is about 95-120 residues long that fold into an 11-stranded beta-sandwich. FHA domains can mediate the recognition of phosphorylated and non-phosphorylated substrates, as well as protein oligomerization. They specifically recognize threonine phosphorylation (pThr) accompanying activation of protein serine/threonine kinases. FHA domains show diverse ligand specificity. They may recognize the pTXXD motif, the pTXXI/L motif, and TQ clusters (singly and multiply phosphorylated). In eukaryotes, FHA superfamily members include forkhead-type transcription factors, as well as other signaling proteins, such as many regulatory proteins, kinases, phosphatases, motor proteins called kinesins, and metabolic enzymes. Many of them localize to the nucleus, where they participate in establishing or maintaining cell cycle checkpoints, DNA repair, or transcriptional regulation. FHA domains play important roles in human diseases, particularly in relation to DNA damage responses and cancers. In bacteria, FHA domain-containing proteins may participate in injection of viral proteins into host cells, transmembrane transporters, and cell division. FHA domain-containing proteins rarely include more than one copy of the domain. The only exception in eukaryotes is the checkpoint kinase Rad53 from Saccharomyces cerevisiae, which harbors two FHA domains (FHA1 and FHA2) flanking a central kinase domain. The two FHA domains recognize different phosphorylated targets and function independently from one another. In contrast, Mycobacterium tuberculosis ABC transporter Rv1747 contains two FHA domains but only one of them is essential for protein function.


Pssm-ID: 438714 [Multi-domain]  Cd Length: 92  Bit Score: 39.57  E-value: 2.50e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 499665365   5 LRVMTGTHAGARLDLAQGRYTLGSDPQTDIRIDDwPGCS---LIIEVDQDG 52
Cdd:cd00060    2 LIVLDGDGGGREFPLTKGVVTIGRSPDCDIVLDD-PSVSrrhARIEVDGGG 51
FHA_Ki67 cd22673
forkhead associated (FHA) domain found in proliferation marker protein Ki-67 and similar ...
 14-54 4.20e-03

forkhead associated (FHA) domain found in proliferation marker protein Ki-67 and similar proteins; Ki-67, also called antigen identified by monoclonal antibody Ki-67, antigen KI-67, or antigen Ki67, acts as a biological surfactant to disperse mitotic chromosomes. It is required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly. Ki-67 binds DNA with a preference for supercoiled DNA and AT-rich DNA. It may also play a role in chromatin organization. Ki-67 contains an FHA domain at its N-terminus. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438725 [Multi-domain]  Cd Length: 95  Bit Score: 36.04  E-value: 4.20e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 499665365  14 GARLDLAQGRYTLGSDPQTDIRIDDwPGCSLI---IEVDQDGQI 54
Cdd:cd22673   13 GSRFPLTKKSCTFGRDLSCDIRIQL-PGVSREhcrIEVDENGKA 55
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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