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Conserved domains on  [gi|499723842|ref|WP_011404576|]
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bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD [Salinibacter ruber]

Protein Classification

bifunctional 5,10-methylenetetrahydrofolate dehydrogenase/5,10-methenyltetrahydrofolate cyclohydrolase( domain architecture ID 11415140)

bifunctional 5,10-methylenetetrahydrofolate dehydrogenase/5,10-methenyltetrahydrofolate cyclohydrolase reversibly catalyzes oxidation of 5,10-methylene-THF to 5,10-methenyl-THF and hydrolysis of 5,10-methenyl-THF to 10-formyl-THF

CATH:  3.40.50.720|3.40.430.10
EC:  1.5.1.5|3.5.4.9
Gene Ontology:  GO:0004488|GO:0003824|GO:0016787|GO:0009086|GO:0006164|GO:0006730
PubMed:  8485162
SCOP:  4000102

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FolD COG0190
5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase ...
 7-294 6.42e-177

5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism];


:

Pssm-ID: 439960 [Multi-domain]  Cd Length: 285  Bit Score: 489.52  E-value: 6.42e-177
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842   7 ADLLDGQALSQAVRDEVKADIQAWTDDHRPPFLSAVLVGDNPASKAYVRGKEKDAAEVGIETETHHLDADTSQSELLDLV 86
Cdd:COG0190    3 AQILDGKAVAAEIREELKERVAALKAKGITPGLAVVLVGDDPASQVYVRNKHKACEEVGIESELIRLPADTTQEELLALI 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842  87 HDLNADASVDGILVQLPLPDHVDERTVIDAVDPSKDVDGFHPENLGRLMRGTPRYIPATPYGIMEMLSRSDIDPESMDAV 166
Cdd:COG0190   83 DELNADPSVHGILVQLPLPKHIDEEAVLEAIDPEKDVDGFHPVNLGRLVLGEPGFVPCTPAGIMELLERYGIDLAGKHAV 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842 167 IVGRSNIVGKPLANLLLRRtaNATVTVCHSRTKDLAAHTRRADLLVAAAGQAAFIDADMVKEDAVVIDVGINRVDDpstd 246
Cdd:COG0190  163 VVGRSNIVGKPLALLLLRR--NATVTVCHSRTKDLAEHTRQADILVAAVGKPGLITADMVKPGAVVIDVGINRVED---- 236

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 499723842 247 rgYRLVGDVDFEGVRPKARRITPVPGGVGLMTRAMLLKNTLKAARLRA 294
Cdd:COG0190  237 --GKLVGDVDFESVAEKASAITPVPGGVGPMTIAMLLENTLKAAERQA 282
 
Name Accession Description Interval E-value
FolD COG0190
5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase ...
 7-294 6.42e-177

5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism];


Pssm-ID: 439960 [Multi-domain]  Cd Length: 285  Bit Score: 489.52  E-value: 6.42e-177
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842   7 ADLLDGQALSQAVRDEVKADIQAWTDDHRPPFLSAVLVGDNPASKAYVRGKEKDAAEVGIETETHHLDADTSQSELLDLV 86
Cdd:COG0190    3 AQILDGKAVAAEIREELKERVAALKAKGITPGLAVVLVGDDPASQVYVRNKHKACEEVGIESELIRLPADTTQEELLALI 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842  87 HDLNADASVDGILVQLPLPDHVDERTVIDAVDPSKDVDGFHPENLGRLMRGTPRYIPATPYGIMEMLSRSDIDPESMDAV 166
Cdd:COG0190   83 DELNADPSVHGILVQLPLPKHIDEEAVLEAIDPEKDVDGFHPVNLGRLVLGEPGFVPCTPAGIMELLERYGIDLAGKHAV 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842 167 IVGRSNIVGKPLANLLLRRtaNATVTVCHSRTKDLAAHTRRADLLVAAAGQAAFIDADMVKEDAVVIDVGINRVDDpstd 246
Cdd:COG0190  163 VVGRSNIVGKPLALLLLRR--NATVTVCHSRTKDLAEHTRQADILVAAVGKPGLITADMVKPGAVVIDVGINRVED---- 236

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 499723842 247 rgYRLVGDVDFEGVRPKARRITPVPGGVGLMTRAMLLKNTLKAARLRA 294
Cdd:COG0190  237 --GKLVGDVDFESVAEKASAITPVPGGVGPMTIAMLLENTLKAAERQA 282
PRK14190 PRK14190
bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...
 7-291 7.82e-135

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional


Pssm-ID: 184560 [Multi-domain]  Cd Length: 284  Bit Score: 383.21  E-value: 7.82e-135
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842   7 ADLLDGQALSQAVRDEVKADIQAWTDDHRPPFLSAVLVGDNPASKAYVRGKEKDAAEVGIETETHHLDADTSQSELLDLV 86
Cdd:PRK14190   3 AVIIDGKEVAKEKREQLKEEVVKLKEQGIVPGLAVILVGDDPASHSYVRGKKKAAEKVGIYSELYEFPADITEEELLALI 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842  87 HDLNADASVDGILVQLPLPDHVDERTVIDAVDPSKDVDGFHPENLGRLMRGTPRYIPATPYGIMEMLSRSDIDPESMDAV 166
Cdd:PRK14190  83 DRLNADPRINGILVQLPLPKHIDEKAVIERISPEKDVDGFHPINVGRMMLGQDTFLPCTPHGILELLKEYNIDISGKHVV 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842 167 IVGRSNIVGKPLANLLLRRtaNATVTVCHSRTKDLAAHTRRADLLVAAAGQAAFIDADMVKEDAVVIDVGINRVDDPstd 246
Cdd:PRK14190 163 VVGRSNIVGKPVGQLLLNE--NATVTYCHSKTKNLAELTKQADILIVAVGKPKLITADMVKEGAVVIDVGVNRLENG--- 237

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 499723842 247 rgyRLVGDVDFEGVRPKARRITPVPGGVGLMTRAMLLKNTLKAAR 291
Cdd:PRK14190 238 ---KLCGDVDFDNVKEKASYITPVPGGVGPMTITMLMHNTVELAK 279
NAD_bind_m-THF_DH_Cyclohyd cd01080
NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; NADP binding ...
 119-291 4.93e-95

NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; NADP binding domain of the Methylene-Tetrahydrofolate Dehydrogenase/cyclohydrolase (m-THF DH/cyclohydrolase) bifunctional enzyme. Tetrahydrofolate is a versatile carrier of activated one-carbon units. The major one-carbon folate donors are N-5 methyltetrahydrofolate, N5,N10-m-THF, and N10-formayltetrahydrofolate. The oxidation of metabolic intermediate m-THF to m-THF requires the enzyme m-THF DH. In addition, most DHs also have an associated cyclohydrolase activity which catalyzes its hydrolysis to N10-formyltetrahydrofolate. m-THF DH is typically found as part of a multifunctional protein in eukaryotes. NADP-dependent m-THF DH in mammals, birds and yeast are components of a trifunctional enzyme with DH, cyclohydrolase, and synthetase activities. Certain eukaryotic cells also contain homodimeric bifunctional DH/cyclodrolase form. In bacteria, monofucntional DH, as well as bifunctional m-THF m-THF DHm-THF DHDH/cyclodrolase are found. In addition, yeast (S. cerevisiae) also express an monofunctional DH. This family contains the bifunctional DH/cyclohydrolase. M-THF DH, like other amino acid DH-like NAD(P)-binding domains, is a member of the Rossmann fold superfamily which includes glutamate, leucine, and phenylalanine DHs, m-THF DH, methylene-tetrahydromethanopterin DH, m-THF DH/cyclohydrolase, Shikimate DH-like proteins, malate oxidoreductases, and glutamyl tRNA reductase. Amino acid DHs catalyze the deamination of amino acids to keto acids with NAD(P)+ as a cofactor. The NAD(P)-binding Rossmann fold superfamily includes a wide variety of protein families including NAD(P)- binding domains of alcohol DHs, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate DH, lactate/malate DHs, formate/glycerate DHs, siroheme synthases, 6-phosphogluconate DH, amino acid DHs, repressor rex, NAD-binding potassium channel domain, CoA-binding, and ornithine cyclodeaminase-like domains.


Pssm-ID: 133448  Cd Length: 168  Bit Score: 277.90  E-value: 4.93e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842 119 PSKDVDGFHPENLGRLMRGTPRYIPATPYGIMEMLSRSDIDPESMDAVIVGRSNIVGKPLANLLLRRtaNATVTVCHSRT 198
Cdd:cd01080    1 PEKDVDGLHPVNLGRLALGRPGFIPCTPAGILELLKRYGIDLAGKKVVVVGRSNIVGKPLAALLLNR--NATVTVCHSKT 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842 199 KDLAAHTRRADLLVAAAGQAAFIDADMVKEDAVVIDVGINRVDDPStdrGYRLVGDVDFEGVRPKARRITPVPGGVGLMT 278
Cdd:cd01080   79 KNLKEHTKQADIVIVAVGKPGLVKGDMVKPGAVVIDVGINRVPDKS---GGKLVGDVDFESAKEKASAITPVPGGVGPMT 155

                        170
                 ....*....|...
gi 499723842 279 RAMLLKNTLKAAR 291
Cdd:cd01080  156 VAMLMKNTVEAAK 168
THF_DHG_CYH_C pfam02882
Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain;
127-294 3.72e-93

Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain;


Pssm-ID: 427036  Cd Length: 160  Bit Score: 272.80  E-value: 3.72e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842  127 HPENLGRLMRGTPRYIPATPYGIMEMLSRSDIDPESMDAVIVGRSNIVGKPLANLLLRrtANATVTVCHSRTKDLAAHTR 206
Cdd:pfam02882   1 HPYNLGRLVLGKPCFVPCTPRGIMELLKRYGIDLAGKNVVVVGRSNIVGKPLALLLLN--ANATVTVCHSKTKDLAEITR 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842  207 RADLLVAAAGQAAFIDADMVKEDAVVIDVGINRVDdpstdrGYRLVGDVDFEGVRPKARRITPVPGGVGLMTRAMLLKNT 286
Cdd:pfam02882  79 EADIVVVAVGKPELIKADWIKPGAVVIDVGINRVG------NGKLVGDVDFENVKEKASAITPVPGGVGPMTVAMLLQNT 152


                  ....*...
gi 499723842  287 LKAARLRA 294
Cdd:pfam02882 153 VEAAKRQL 160
 
Name Accession Description Interval E-value
FolD COG0190
5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase ...
 7-294 6.42e-177

5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism];


Pssm-ID: 439960 [Multi-domain]  Cd Length: 285  Bit Score: 489.52  E-value: 6.42e-177
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842   7 ADLLDGQALSQAVRDEVKADIQAWTDDHRPPFLSAVLVGDNPASKAYVRGKEKDAAEVGIETETHHLDADTSQSELLDLV 86
Cdd:COG0190    3 AQILDGKAVAAEIREELKERVAALKAKGITPGLAVVLVGDDPASQVYVRNKHKACEEVGIESELIRLPADTTQEELLALI 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842  87 HDLNADASVDGILVQLPLPDHVDERTVIDAVDPSKDVDGFHPENLGRLMRGTPRYIPATPYGIMEMLSRSDIDPESMDAV 166
Cdd:COG0190   83 DELNADPSVHGILVQLPLPKHIDEEAVLEAIDPEKDVDGFHPVNLGRLVLGEPGFVPCTPAGIMELLERYGIDLAGKHAV 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842 167 IVGRSNIVGKPLANLLLRRtaNATVTVCHSRTKDLAAHTRRADLLVAAAGQAAFIDADMVKEDAVVIDVGINRVDDpstd 246
Cdd:COG0190  163 VVGRSNIVGKPLALLLLRR--NATVTVCHSRTKDLAEHTRQADILVAAVGKPGLITADMVKPGAVVIDVGINRVED---- 236

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 499723842 247 rgYRLVGDVDFEGVRPKARRITPVPGGVGLMTRAMLLKNTLKAARLRA 294
Cdd:COG0190  237 --GKLVGDVDFESVAEKASAITPVPGGVGPMTIAMLLENTLKAAERQA 282
PRK14190 PRK14190
bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...
 7-291 7.82e-135

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional


Pssm-ID: 184560 [Multi-domain]  Cd Length: 284  Bit Score: 383.21  E-value: 7.82e-135
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842   7 ADLLDGQALSQAVRDEVKADIQAWTDDHRPPFLSAVLVGDNPASKAYVRGKEKDAAEVGIETETHHLDADTSQSELLDLV 86
Cdd:PRK14190   3 AVIIDGKEVAKEKREQLKEEVVKLKEQGIVPGLAVILVGDDPASHSYVRGKKKAAEKVGIYSELYEFPADITEEELLALI 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842  87 HDLNADASVDGILVQLPLPDHVDERTVIDAVDPSKDVDGFHPENLGRLMRGTPRYIPATPYGIMEMLSRSDIDPESMDAV 166
Cdd:PRK14190  83 DRLNADPRINGILVQLPLPKHIDEKAVIERISPEKDVDGFHPINVGRMMLGQDTFLPCTPHGILELLKEYNIDISGKHVV 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842 167 IVGRSNIVGKPLANLLLRRtaNATVTVCHSRTKDLAAHTRRADLLVAAAGQAAFIDADMVKEDAVVIDVGINRVDDPstd 246
Cdd:PRK14190 163 VVGRSNIVGKPVGQLLLNE--NATVTYCHSKTKNLAELTKQADILIVAVGKPKLITADMVKEGAVVIDVGVNRLENG--- 237

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 499723842 247 rgyRLVGDVDFEGVRPKARRITPVPGGVGLMTRAMLLKNTLKAAR 291
Cdd:PRK14190 238 ---KLCGDVDFDNVKEKASYITPVPGGVGPMTITMLMHNTVELAK 279
PRK10792 PRK10792
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...
 7-291 2.84e-127

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;


Pssm-ID: 236760 [Multi-domain]  Cd Length: 285  Bit Score: 363.85  E-value: 2.84e-127
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842   7 ADLLDGQALSQAVRDEVKADIQAWTDD-HRPPFLSAVLVGDNPASKAYVRGKEKDAAEVGIETETHHLDADTSQSELLDL 85
Cdd:PRK10792   3 AKIIDGKTIAQQVRSEVAQKVQARVAAgLRAPGLAVVLVGSDPASQVYVASKRKACEEVGFVSRSYDLPETTSEAELLAL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842  86 VHDLNADASVDGILVQLPLPDHVDERTVIDAVDPSKDVDGFHPENLGRLMRGTPRYIPATPYGIMEMLSRSDIDPESMDA 165
Cdd:PRK10792  83 IDELNADPTIDGILVQLPLPAHIDNVKVLERIHPDKDVDGFHPYNVGRLAQRIPLLRPCTPRGIMTLLERYGIDTYGLNA 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842 166 VIVGRSNIVGKPLA-NLLLrrtANATVTVCHSRTKDLAAHTRRADLLVAAAGQAAFIDADMVKEDAVVIDVGINRVDDPs 244
Cdd:PRK10792 163 VVVGASNIVGRPMSlELLL---AGCTVTVCHRFTKNLRHHVRNADLLVVAVGKPGFIPGEWIKPGAIVIDVGINRLEDG- 238

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 499723842 245 tdrgyRLVGDVDFEGVRPKARRITPVPGGVGLMTRAMLLKNTLKAAR 291
Cdd:PRK10792 239 -----KLVGDVEFETAAERASWITPVPGGVGPMTVATLLENTLQACE 280
PRK14189 PRK14189
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase;
7-297 7.93e-125

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase;


Pssm-ID: 184559 [Multi-domain]  Cd Length: 285  Bit Score: 357.85  E-value: 7.93e-125
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842   7 ADLLDGQALSQAVRDEVKADIQAWTDDHRPPFLSAVLVGDNPASKAYVRGKEKDAAEVGIETETHHLDADTSQSELLDLV 86
Cdd:PRK14189   3 AQLIDGNALSKQLRAEAAQRAAALTARGHQPGLAVILVGDNPASQVYVRNKVKACEDNGFHSLKDRYPADLSEAELLARI 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842  87 HDLNADASVDGILVQLPLPDHVDERTVIDAVDPSKDVDGFHPENLGRLMRGTPRYIPATPYGIMEMLSRSDIDPESMDAV 166
Cdd:PRK14189  83 DELNRDPKIHGILVQLPLPKHIDSHKVIEAIAPEKDVDGFHVANAGALMTGQPLFRPCTPYGVMKMLESIGIPLRGAHAV 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842 167 IVGRSNIVGKPLANLLLRrtANATVTVCHSRTKDLAAHTRRADLLVAAAGQAAFIDADMVKEDAVVIDVGINRVDDPstd 246
Cdd:PRK14189 163 VIGRSNIVGKPMAMLLLQ--AGATVTICHSKTRDLAAHTRQADIVVAAVGKRNVLTADMVKPGATVIDVGMNRDDAG--- 237

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 499723842 247 rgyRLVGDVDFEGVRPKARRITPVPGGVGLMTRAMLLKNTLKAARLRATSA 297
Cdd:PRK14189 238 ---KLCGDVDFAGVKEVAGYITPVPGGVGPMTITMLLVNTIEAAERAAAAA 285
PRK14191 PRK14191
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...
 9-294 1.45e-124

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;


Pssm-ID: 172679 [Multi-domain]  Cd Length: 285  Bit Score: 357.15  E-value: 1.45e-124
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842   9 LLDGQALSQAVRDEVKADIQAWTDD-HRPPFLSAVLVGDNPASKAYVRGKEKDAAEVGIETETHHLDADTSQSELLDLVH 87
Cdd:PRK14191   3 LLDGKALSYKIEKDLKNKIQILTAQtGKRPKLAVILVGKDPASQTYVNMKIKACERVGMDSDLHTLQENTTEAELLSLIK 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842  88 DLNADASVDGILVQLPLPDHVDERTVIDAVDPSKDVDGFHPENLGRLMRGTPRYIPATPYGIMEMLSRSDIDPESMDAVI 167
Cdd:PRK14191  83 DLNTDQNIDGILVQLPLPRHIDTKMVLEAIDPNKDVDGFHPLNIGKLCSQLDGFVPATPMGVMRLLKHYHIEIKGKDVVI 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842 168 VGRSNIVGKPLANLLLrrTANATVTVCHSRTKDLAAHTRRADLLVAAAGQAAFIDADMVKEDAVVIDVGINRVDDPstdr 247
Cdd:PRK14191 163 IGASNIVGKPLAMLML--NAGASVSVCHILTKDLSFYTQNADIVCVGVGKPDLIKASMVKKGAVVVDIGINRLNDG---- 236

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 499723842 248 gyRLVGDVDFEGVRPKARRITPVPGGVGLMTRAMLLKNTLKAARLRA 294
Cdd:PRK14191 237 --RLVGDVDFENVAPKASFITPVPGGVGPMTIVSLLENTLIAAEKRQ 281
PRK14167 PRK14167
bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...
 7-294 8.31e-122

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional


Pssm-ID: 184549 [Multi-domain]  Cd Length: 297  Bit Score: 350.62  E-value: 8.31e-122
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842   7 ADLLDGQALSQAVRDEVKADIQAWTDDHRPPFLSAVLVGDNPASKAYVRGKEKDAAEVGIETETHHLDADTSQSELLDLV 86
Cdd:PRK14167   2 TEIIDGNAVAAQIRDDLTDAIETLEDAGVTPGLATVLMSDDPASETYVSMKQRDCEEVGIEAIDVEIDPDAPAEELYDTI 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842  87 HDLNADASVDGILVQLPLPDHVDERTVIDAVDPSKDVDGFHPENLGRLMRGTPRYIPATPYGIMEMLSRSDIDPESMDAV 166
Cdd:PRK14167  82 DELNADEDVHGILVQMPVPDHVDDREVLRRIDPAKDVDGFHPENVGRLVAGDARFKPCTPHGIQKLLAAAGVDTEGADVV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842 167 IVGRSNIVGKPLANLLLRR--TANATVTVCHSRTKDLAAHTRRADLLVAAAGQAAFIDADMVKEDAVVIDVGINRVDDpS 244
Cdd:PRK14167 162 VVGRSDIVGKPMANLLIQKadGGNATVTVCHSRTDDLAAKTRRADIVVAAAGVPELIDGSMLSEGATVIDVGINRVDA-D 240

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 499723842 245 TDRGYRLVGDVDFEGVRPKARRITPVPGGVGLMTRAMLLKNTLKAARLRA 294
Cdd:PRK14167 241 TEKGYELVGDVEFESAKEKASAITPVPGGVGPMTRAMLLYNTVKAASLQE 290
PRK14188 PRK14188
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...
 7-291 1.88e-121

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;


Pssm-ID: 184558 [Multi-domain]  Cd Length: 296  Bit Score: 349.64  E-value: 1.88e-121
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842   7 ADLLDGQALSQAVRDEVKADIQAWTDDH-RPPFLSAVLVGDNPASKAYVRGKEKDAAEVGIETETHHLDADTSQSELLDL 85
Cdd:PRK14188   2 ATIIDGKAFAADVRATVAAEVARLKAAHgVTPGLAVVLVGEDPASQVYVRSKGKQTKEAGMASFEHKLPADTSQAELLAL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842  86 VHDLNADASVDGILVQLPLPDHVDERTVIDAVDPSKDVDGFHPENLGRLMRGTPRYIPATPYGIMEMLSRSDIDPESMDA 165
Cdd:PRK14188  82 IARLNADPAIHGILVQLPLPKHLDSEAVIQAIDPEKDVDGLHVVNAGRLATGETALVPCTPLGCMMLLRRVHGDLSGLNA 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842 166 VIVGRSNIVGKPLANLLLRrtANATVTVCHSRTKDLAAHTRRADLLVAAAGQAAFIDADMVKEDAVVIDVGINRVDDPST 245
Cdd:PRK14188 162 VVIGRSNLVGKPMAQLLLA--ANATVTIAHSRTRDLPAVCRRADILVAAVGRPEMVKGDWIKPGATVIDVGINRIPAPEK 239

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 499723842 246 DRG-YRLVGDVDFEGVRPKARRITPVPGGVGLMTRAMLLKNTLKAAR 291
Cdd:PRK14188 240 GEGkTRLVGDVAFAEAAEVAGAITPVPGGVGPMTIACLLANTLTAAC 286
PRK14174 PRK14174
bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...
 9-289 2.87e-120

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional


Pssm-ID: 172662 [Multi-domain]  Cd Length: 295  Bit Score: 346.42  E-value: 2.87e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842   9 LLDGQALSQAVRDEVKADIQAWTDD-HRPPFLSAVLVGDNPASKAYVRGKEKDAAEVGIETETHHLDADTSQSELLDLVH 87
Cdd:PRK14174   3 IIDGKKVSLDLKNELKTRVEAYRAKtGKVPGLTVIIVGEDPASQVYVRNKAKSCKEIGMNSTVIELPADTTEEHLLKKIE 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842  88 DLNADASVDGILVQLPLPDHVDERTVIDAVDPSKDVDGFHPENLGRLMRG--TPRYIPATPYGIMEMLSRSDIDPESMDA 165
Cdd:PRK14174  83 DLNNDPDVHGILVQQPLPKQIDEFAVTLAIDPAKDVDGFHPENLGRLVMGhlDKCFVSCTPYGILELLGRYNIETKGKHC 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842 166 VIVGRSNIVGKPLANLLLR--RTANATVTVCHSRTKDLAAHTRRADLLVAAAGQAAFIDADMVKEDAVVIDVGINRVDDP 243
Cdd:PRK14174 163 VVVGRSNIVGKPMANLMLQklKESNCTVTICHSATKDIPSYTRQADILIAAIGKARFITADMVKPGAVVIDVGINRIEDP 242

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 499723842 244 STDRGYRLVGDVDFEGVRPKARRITPVPGGVGLMTRAMLLKNTLKA 289
Cdd:PRK14174 243 STKSGYRLVGDVDYEGVSAKASAITPVPGGVGPMTIAMLLKNTLQS 288
PRK14186 PRK14186
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...
 7-294 2.95e-119

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;


Pssm-ID: 237636 [Multi-domain]  Cd Length: 297  Bit Score: 343.97  E-value: 2.95e-119
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842   7 ADLLDGQALSQAVRDEVKADIQAW-TDDHRPPFLSAVLVGDNPASKAYVRGKEKDAAEVGIETETHHLDADTSQSELLDL 85
Cdd:PRK14186   2 ALILDGKALAAEIEQRLQAQIESNlPKAGRPPGLAVLRVGDDPASAVYVRNKEKACARVGIASFGKHLPADTSQAEVEAL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842  86 VHDLNADASVDGILVQLPLPDHVDERTVIDAVDPSKDVDGFHPENLGRLMRGTPRYIPATPYGIMEMLSRSDIDPESMDA 165
Cdd:PRK14186  82 IAQLNQDERVDGILLQLPLPKHLDEVPLLHAIDPDKDADGLHPLNLGRLVKGEPGLRSCTPAGVMRLLRSQQIDIAGKKA 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842 166 VIVGRSNIVGKPLANLLLrrTANATVTVCHSRTKDLAAHTRRADLLVAAAGQAAFIDADMVKEDAVVIDVGINRVddPST 245
Cdd:PRK14186 162 VVVGRSILVGKPLALMLL--AANATVTIAHSRTQDLASITREADILVAAAGRPNLIGAEMVKPGAVVVDVGIHRL--PSS 237

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 499723842 246 DRGYRLVGDVDFEGVRPKARRITPVPGGVGLMTRAMLLKNTLKAARLRA 294
Cdd:PRK14186 238 DGKTRLCGDVDFEEVEPVAAAITPVPGGVGPMTVTMLLVNTVLSWQKRH 286
PRK14184 PRK14184
bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...
 9-293 7.19e-118

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional


Pssm-ID: 237635 [Multi-domain]  Cd Length: 286  Bit Score: 340.21  E-value: 7.19e-118
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842   9 LLDGQALSQAVRDEVKADIQAWTDDH-RPPFLSAVLVGDNPASKAYVRGKEKDAAEVGIETETHHLDADTSQSELLDLVH 87
Cdd:PRK14184   3 LLDGKATAATIREELKTEVAALTARHgRAPGLAVILVGEDPASQVYVRNKERACEDAGIVSEAFRLPADTTQEELEDLIA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842  88 DLNADASVDGILVQLPLPDHVDERTVIDAVDPSKDVDGFHPENLGRLMRGTPRYIPATPYGIMEMLSRSDIDPESMDAVI 167
Cdd:PRK14184  83 ELNARPDIDGILLQLPLPKGLDSQRCLELIDPAKDVDGFHPENMGRLALGLPGFRPCTPAGVMTLLERYGLSPAGKKAVV 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842 168 VGRSNIVGKPLANLLLR--RTANATVTVCHSRTKDLAAHTRRADLLVAAAGQAAFIDADMVKEDAVVIDVGINRVDDPst 245
Cdd:PRK14184 163 VGRSNIVGKPLALMLGApgKFANATVTVCHSRTPDLAEECREADFLFVAIGRPRFVTADMVKPGAVVVDVGINRTDDG-- 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 499723842 246 drgyrLVGDVDFEGVRPKARRITPVPGGVGLMTRAMLLKNTLKAARLR 293
Cdd:PRK14184 241 -----LVGDCDFEGLSDVASAITPVPGGVGPMTIAQLLVNTVQSWKER 283
PRK14179 PRK14179
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase;
7-297 1.61e-111

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase;


Pssm-ID: 237634 [Multi-domain]  Cd Length: 284  Bit Score: 324.01  E-value: 1.61e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842   7 ADLLDGQALSQAVRDEVKADIQAWTDDH-RPPFLSAVLVGDNPASKAYVRGKEKDAAEVGIETETHHLDADTSQSELLDL 85
Cdd:PRK14179   2 TEIIDGKALAQKMQAELAEKVAKLKEEKgIVPGLVVILVGDNPASQVYVRNKERSALAAGFKSEVVRLPETISQEELLDL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842  86 VHDLNADASVDGILVQLPLPDHVDERTVIDAVDPSKDVDGFHPENLGRLMRGTPRYIPATPYGIMEMLSRSDIDPESMDA 165
Cdd:PRK14179  82 IERYNQDPTWHGILVQLPLPKHINEEKILLAIDPKKDVDGFHPMNTGHLWSGRPVMIPCTPAGIMEMFREYNVELEGKHA 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842 166 VIVGRSNIVGKPLANLLLrrTANATVTVCHSRTKDLAAHTRRADLLVAAAGQAAFIDADMVKEDAVVIDVGINRvddpst 245
Cdd:PRK14179 162 VVIGRSNIVGKPMAQLLL--DKNATVTLTHSRTRNLAEVARKADILVVAIGRGHFVTKEFVKEGAVVIDVGMNR------ 233

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 499723842 246 DRGYRLVGDVDFEGVRPKARRITPVPGGVGLMTRAMLLKNTLKAArLRATSA 297
Cdd:PRK14179 234 DENGKLIGDVDFDEVAEVASYITPVPGGVGPMTITMLMEQTYQAA-LRSLHK 284
PRK14176 PRK14176
bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...
 1-291 6.29e-111

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional


Pssm-ID: 184553 [Multi-domain]  Cd Length: 287  Bit Score: 322.53  E-value: 6.29e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842   1 MPDASDADLLDGQALSQAVRDEVKADIQAWTDDHR-PPFLSAVLVGDNPASKAYVRGKEKDAAEVGIETETHHLDADTSQ 79
Cdd:PRK14176   2 MDESYESRIIDGKALAKKIEAEVRSGVERLKSNRGiTPGLATILVGDDPASKMYVRLKHKACERVGIRAEDQFLPADTTQ 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842  80 SELLDLVHDLNADASVDGILVQLPLPDHVDERTVIDAVDPSKDVDGFHPENLGRLMRGTPRYIPATPYGIMEMLSRSDID 159
Cdd:PRK14176  82 EELLELIDSLNKRKDVHGILLQLPLPKHLDPQEAMEAIDPAKDADGFHPYNMGKLMIGDEGLVPCTPHGVIRALEEYGVD 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842 160 PESMDAVIVGRSNIVGKPLANLLLRRtaNATVTVCHSRTKDLAAHTRRADLLVAAAGQAAFIDADMVKEDAVVIDVGINR 239
Cdd:PRK14176 162 IEGKNAVIVGHSNVVGKPMAAMLLNR--NATVSVCHVFTDDLKKYTLDADILVVATGVKHLIKADMVKEGAVIFDVGITK 239

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 499723842 240 VDDpstdrgyRLVGDVDFEGVRPKARRITPVPGGVGLMTRAMLLKNTLKAAR 291
Cdd:PRK14176 240 EED-------KVYGDVDFENVIKKASLITPVPGGVGPLTIAMLMKHVLMCAE 284
PRK14183 PRK14183
bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...
 9-294 4.41e-107

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional


Pssm-ID: 184555 [Multi-domain]  Cd Length: 281  Bit Score: 312.53  E-value: 4.41e-107
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842   9 LLDGQALSQAVRDEVKADIQAW-TDDHRPPFLSAVLVGDNPASKAYVRGKEKDAAEVGIETETHHLDADTSQSELLDLVH 87
Cdd:PRK14183   3 ILDGKALSDKIKENVKKEVDELkLVKNIVPGLAVILVGDDPASHTYVKMKAKACDRVGIYSITHEMPSTISQKEILETIA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842  88 DLNADASVDGILVQLPLPDHVDERTVIDAVDPSKDVDGFHPENLGRLMRGTPRYIPATPYGIMEMLSRSDIDPESMDAVI 167
Cdd:PRK14183  83 MMNNNPNIDGILVQLPLPKHIDTTKILEAIDPKKDVDGFHPYNVGRLVTGLDGFVPCTPLGVMELLEEYEIDVKGKDVCV 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842 168 VGRSNIVGKPLANLLLrrTANATVTVCHSRTKDLAAHTRRADLLVAAAGQAAFIDADMVKEDAVVIDVGINRVDDPstdr 247
Cdd:PRK14183 163 VGASNIVGKPMAALLL--NANATVDICHIFTKDLKAHTKKADIVIVGVGKPNLITEDMVKEGAIVIDIGINRTEDG---- 236

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 499723842 248 gyRLVGDVDFEGVRPKARRITPVPGGVGLMTRAMLLKNTLKAARLRA 294
Cdd:PRK14183 237 --RLVGDVDFENVAKKCSYITPVPGGVGPMTIAMLLSNTLKAAKNRA 281
PRK14166 PRK14166
bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...
 9-293 2.93e-106

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional


Pssm-ID: 172654 [Multi-domain]  Cd Length: 282  Bit Score: 310.80  E-value: 2.93e-106
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842   9 LLDGQALSQAVRDEVKADIQAWTDDHRPPFLSAVLVGDNPASKAYVRGKEKDAAEVGIETETHHLDADTSQSELLDLVHD 88
Cdd:PRK14166   3 LLDGKALSAKIKEELKEKNQFLKSKGIESCLAVILVGDNPASQTYVKSKAKACEECGIKSLVYHLNENTTQNELLALINT 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842  89 LNADASVDGILVQLPLPDHVDERTVIDAVDPSKDVDGFHPENLGRLMRGTPR-YIPATPYGIMEMLSRSDIDPESMDAVI 167
Cdd:PRK14166  83 LNHDDSVHGILVQLPLPDHICKDLILESIISSKDVDGFHPINVGYLNLGLESgFLPCTPLGVMKLLKAYEIDLEGKDAVI 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842 168 VGRSNIVGKPLANLLLrrTANATVTVCHSRTKDLAAHTRRADLLVAAAGQAAFIDADMVKEDAVVIDVGINRVDDPstdr 247
Cdd:PRK14166 163 IGASNIVGRPMATMLL--NAGATVSVCHIKTKDLSLYTRQADLIIVAAGCVNLLRSDMVKEGVIVVDVGINRLESG---- 236

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 499723842 248 gyRLVGDVDFEGVRPKARRITPVPGGVGLMTRAMLLKNTLKAARLR 293
Cdd:PRK14166 237 --KIVGDVDFEEVSKKSSYITPVPGGVGPMTIAMLLENTVKSAKNR 280
PRK14193 PRK14193
bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...
 7-294 3.87e-104

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional


Pssm-ID: 237637 [Multi-domain]  Cd Length: 284  Bit Score: 305.40  E-value: 3.87e-104
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842   7 ADLLDGQALSQAVRDEVKADIQAWTDDHRPPFLSAVLVGDNPASKAYVRGKEKDAAEVGIETETHHLDADTSQSELLDLV 86
Cdd:PRK14193   3 AIILDGKATADEIKADLAERVAALKEKGITPGLGTVLVGDDPGSQAYVRGKHRDCAEVGITSIRRDLPADATQEELNAVI 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842  87 HDLNADASVDGILVQLPLPDHVDERTVIDAVDPSKDVDGFHPENLGRLMRGTPRYIPATPYGIMEMLSRSDIDPESMDAV 166
Cdd:PRK14193  83 DELNADPACTGYIVQLPLPKHLDENAVLERIDPAKDADGLHPTNLGRLVLNEPAPLPCTPRGIVHLLRRYDVELAGAHVV 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842 167 IVGRSNIVGKPLANLLLRRTANATVTVCHSRTKDLAAHTRRADLLVAAAGQAAFIDADMVKEDAVVIDVGINRVDDpstd 246
Cdd:PRK14193 163 VIGRGVTVGRPIGLLLTRRSENATVTLCHTGTRDLAAHTRRADIIVAAAGVAHLVTADMVKPGAAVLDVGVSRAGD---- 238

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 499723842 247 rgYRLVGDVDfEGVRPKARRITPVPGGVGLMTRAMLLKNTLKAARLRA 294
Cdd:PRK14193 239 --GKLVGDVH-PDVWEVAGAVSPNPGGVGPMTRAFLLTNVVERAERRA 283
PRK14185 PRK14185
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...
 9-291 7.24e-100

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;


Pssm-ID: 184556 [Multi-domain]  Cd Length: 293  Bit Score: 294.81  E-value: 7.24e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842   9 LLDGQALSQAVRDEVKADIQAWTDD-HRPPFLSAVLVGDNPASKAYVRGKEKDAAEVGIETETHHLDADTSQSELLDLVH 87
Cdd:PRK14185   3 LIDGKAISAQIKQEIAAEVAEIVAKgGKRPHLAAILVGHDGGSETYVANKVKACEECGFKSSLIRYESDVTEEELLAKVR 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842  88 DLNADASVDGILVQLPLPDHVDERTVIDAVDPSKDVDGFHPENLGRLMRGTPRYIPATPYGIMEMLSRSDIDPESMDAVI 167
Cdd:PRK14185  83 ELNQDDDVDGFIVQLPLPKHISEQKVIEAIDYRKDVDGFHPINVGRMSIGLPCFVSATPNGILELLKRYHIETSGKKCVV 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842 168 VGRSNIVGKPLANLLLRRT--ANATVTVCHSRTKDLAAHTRRADLLVAAAGQAAFIDADMVKEDAVVIDVGINRVDDPST 245
Cdd:PRK14185 163 LGRSNIVGKPMAQLMMQKAypGDCTVTVCHSRSKNLKKECLEADIIIAALGQPEFVKADMVKEGAVVIDVGTTRVPDATR 242

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 499723842 246 DRGYRLVGDVDFEGVRPKARRITPVPGGVGLMTRAMLLKNTLKAAR 291
Cdd:PRK14185 243 KSGFKLTGDVKFDEVAPKCSYITPVPGGVGPMTIVSLMKNTLLAGK 288
PLN02516 PLN02516
methylenetetrahydrofolate dehydrogenase (NADP+)
 2-291 1.44e-99

methylenetetrahydrofolate dehydrogenase (NADP+)


Pssm-ID: 178131 [Multi-domain]  Cd Length: 299  Bit Score: 294.11  E-value: 1.44e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842   2 PDASDADLLDGQALSQAVRDEVKADIQAWTDDH-RPPFLSAVLVGDNPASKAYVRGKEKDAAEVGIETETHHLDADTSQS 80
Cdd:PLN02516   4 PSDHVAQIIDGKAIAKAIRSEIAEEVAQLSEKHgKVPGLAVVIVGSRKDSQTYVNMKRKACAEVGIKSFDVDLPENISEA 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842  81 ELLDLVHDLNADASVDGILVQLPLPDHVDERTVIDAVDPSKDVDGFHPENLGRL-MRG-TPRYIPATPYGIMEMLSRSDI 158
Cdd:PLN02516  84 ELISKVHELNANPDVHGILVQLPLPKHINEEKILNEISLEKDVDGFHPLNIGKLaMKGrEPLFLPCTPKGCLELLSRSGI 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842 159 DPESMDAVIVGRSNIVGKPLANLLLRrtANATVTVCHSRTKDLAAHTRRADLLVAAAGQAAFIDADMVKEDAVVIDVGIN 238
Cdd:PLN02516 164 PIKGKKAVVVGRSNIVGLPVSLLLLK--ADATVTVVHSRTPDPESIVREADIVIAAAGQAMMIKGDWIKPGAAVIDVGTN 241

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 499723842 239 RVDDPSTDRGYRLVGDVDFEGVRPKARRITPVPGGVGLMTRAMLLKNTLKAAR 291
Cdd:PLN02516 242 AVSDPSKKSGYRLVGDVDFAEVSKVAGWITPVPGGVGPMTVAMLLKNTVDGAK 294
PRK14173 PRK14173
bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...
 7-294 9.87e-98

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional


Pssm-ID: 184551 [Multi-domain]  Cd Length: 287  Bit Score: 289.04  E-value: 9.87e-98
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842   7 ADLLDGQALSQAVRDEVKADIQAWTDdhrPPFLSAVLVGDNPASKAYVRGKEKDAAEVGIETETHHLDADTSQSELLDLV 86
Cdd:PRK14173   3 ARELSGPPAAEAVYAELRARLAKLPF---VPHLRVVRLGEDPASVSYVRLKDRQAKALGLRSQVEVLPESTSQEELLELI 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842  87 HDLNADASVDGILVQLPLPDHVDERTVIDAVDPSKDVDGFHPENLGRLMRGTPRYIPATPYGIMEMLSRSDIDPESMDAV 166
Cdd:PRK14173  80 ARLNADPEVDGILVQLPLPPHIDFQRVLEAIDPLKDVDGFHPLNVGRLWMGGEALEPCTPAGVVRLLKHYGIPLAGKEVV 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842 167 IVGRSNIVGKPLANLLLRRtaNATVTVCHSRTKDLAAHTRRADLLVAAAGQAAFIDADMVKEDAVVIDVGINRVddPSTD 246
Cdd:PRK14173 160 VVGRSNIVGKPLAALLLRE--DATVTLAHSKTQDLPAVTRRADVLVVAVGRPHLITPEMVRPGAVVVDVGINRV--GGNG 235

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 499723842 247 RGYRLVGDVDfEGVRPKARRITPVPGGVGLMTRAMLLKNTLKAARLRA 294
Cdd:PRK14173 236 GRDILTGDVH-PEVAEVAGALTPVPGGVGPMTVAMLMANTVIAALRRR 282
PRK14182 PRK14182
bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...
 9-291 4.93e-97

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional


Pssm-ID: 172670 [Multi-domain]  Cd Length: 282  Bit Score: 287.30  E-value: 4.93e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842   9 LLDGQALSQAVRDEVKADIQAWTDDHRPPFLSAVLVGDNPASKAYVRGKEKDAAEVGIETETHHLDADTSQSELLDLVHD 88
Cdd:PRK14182   3 LIDGKQIAAKVKGEVATEVRALAARGVQTGLTVVRVGDDPASAIYVRGKRKDCEEVGITSVEHHLPATTTQAELLALIAR 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842  89 LNADASVDGILVQLPLPDHVDERTVIDAVDPSKDVDGFHPENLGRL---MRGTPRyiPATPYGIMEMLSRSDIDPESMDA 165
Cdd:PRK14182  83 LNADPAVHGILVQLPLPKHVDERAVLDAISPAKDADGFHPFNVGALsigIAGVPR--PCTPAGVMRMLDEARVDPKGKRA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842 166 VIVGRSNIVGKPLANLLLRRtaNATVTVCHSRTKDLAAHTRRADLLVAAAGQAAFIDADMVKEDAVVIDVGINRVDDPst 245
Cdd:PRK14182 161 LVVGRSNIVGKPMAMMLLER--HATVTIAHSRTADLAGEVGRADILVAAIGKAELVKGAWVKEGAVVIDVGMNRLADG-- 236

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 499723842 246 drgyRLVGDVDFEGVRPKARRITPVPGGVGLMTRAMLLKNTLKAAR 291
Cdd:PRK14182 237 ----KLVGDVEFAAAAARASAITPVPGGVGPMTRAMLLVNTVELAK 278
PRK14194 PRK14194
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...
 7-297 4.37e-95

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;


Pssm-ID: 172682 [Multi-domain]  Cd Length: 301  Bit Score: 282.89  E-value: 4.37e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842   7 ADLLDGQALSQAVRDEVKADIQAWTDDHRPPFLSAVLVGDNPASKAYVRGKEKDAAEVGIETETHHLDADTSQSELLDLV 86
Cdd:PRK14194   4 AKLIDGKAAAARVLAQVREDVRTLKAAGIEPALAVILVGNDPASQVYVRNKILRAEEAGIRSLEHRLPADTSQARLLALI 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842  87 HDLNADASVDGILVQLPLPDHVDERTVIDAVDPSKDVDGFHPENLGRLMRGTPRYIPATPYGIMEMLSRSDIDPESMDAV 166
Cdd:PRK14194  84 AELNADPSVNGILLQLPLPAHIDEARVLQAINPLKDVDGFHSENVGGLSQGRDVLTPCTPSGCLRLLEDTCGDLTGKHAV 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842 167 IVGRSNIVGKPLANLLLRrtANATVTVCHSRTKDLAAHTRRADLLVAAAGQAAFIDADMVKEDAVVIDVGINRVDDpstD 246
Cdd:PRK14194 164 VIGRSNIVGKPMAALLLQ--AHCSVTVVHSRSTDAKALCRQADIVVAAVGRPRLIDADWLKPGAVVIDVGINRIDD---D 238

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 499723842 247 RGYRLVGDVDFEGVRPKARRITPVPGGVGLMTRAMLLKNTLKAARLRATSA 297
Cdd:PRK14194 239 GRSRLVGDVDFDSALPVVSAITPVPGGVGPMTIAFLMKNTVTAARLQAHAQ 289
NAD_bind_m-THF_DH_Cyclohyd cd01080
NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; NADP binding ...
 119-291 4.93e-95

NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; NADP binding domain of the Methylene-Tetrahydrofolate Dehydrogenase/cyclohydrolase (m-THF DH/cyclohydrolase) bifunctional enzyme. Tetrahydrofolate is a versatile carrier of activated one-carbon units. The major one-carbon folate donors are N-5 methyltetrahydrofolate, N5,N10-m-THF, and N10-formayltetrahydrofolate. The oxidation of metabolic intermediate m-THF to m-THF requires the enzyme m-THF DH. In addition, most DHs also have an associated cyclohydrolase activity which catalyzes its hydrolysis to N10-formyltetrahydrofolate. m-THF DH is typically found as part of a multifunctional protein in eukaryotes. NADP-dependent m-THF DH in mammals, birds and yeast are components of a trifunctional enzyme with DH, cyclohydrolase, and synthetase activities. Certain eukaryotic cells also contain homodimeric bifunctional DH/cyclodrolase form. In bacteria, monofucntional DH, as well as bifunctional m-THF m-THF DHm-THF DHDH/cyclodrolase are found. In addition, yeast (S. cerevisiae) also express an monofunctional DH. This family contains the bifunctional DH/cyclohydrolase. M-THF DH, like other amino acid DH-like NAD(P)-binding domains, is a member of the Rossmann fold superfamily which includes glutamate, leucine, and phenylalanine DHs, m-THF DH, methylene-tetrahydromethanopterin DH, m-THF DH/cyclohydrolase, Shikimate DH-like proteins, malate oxidoreductases, and glutamyl tRNA reductase. Amino acid DHs catalyze the deamination of amino acids to keto acids with NAD(P)+ as a cofactor. The NAD(P)-binding Rossmann fold superfamily includes a wide variety of protein families including NAD(P)- binding domains of alcohol DHs, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate DH, lactate/malate DHs, formate/glycerate DHs, siroheme synthases, 6-phosphogluconate DH, amino acid DHs, repressor rex, NAD-binding potassium channel domain, CoA-binding, and ornithine cyclodeaminase-like domains.


Pssm-ID: 133448  Cd Length: 168  Bit Score: 277.90  E-value: 4.93e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842 119 PSKDVDGFHPENLGRLMRGTPRYIPATPYGIMEMLSRSDIDPESMDAVIVGRSNIVGKPLANLLLRRtaNATVTVCHSRT 198
Cdd:cd01080    1 PEKDVDGLHPVNLGRLALGRPGFIPCTPAGILELLKRYGIDLAGKKVVVVGRSNIVGKPLAALLLNR--NATVTVCHSKT 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842 199 KDLAAHTRRADLLVAAAGQAAFIDADMVKEDAVVIDVGINRVDDPStdrGYRLVGDVDFEGVRPKARRITPVPGGVGLMT 278
Cdd:cd01080   79 KNLKEHTKQADIVIVAVGKPGLVKGDMVKPGAVVIDVGINRVPDKS---GGKLVGDVDFESAKEKASAITPVPGGVGPMT 155

                        170
                 ....*....|...
gi 499723842 279 RAMLLKNTLKAAR 291
Cdd:cd01080  156 VAMLMKNTVEAAK 168
PRK14172 PRK14172
bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...
 8-289 1.98e-94

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional


Pssm-ID: 172660 [Multi-domain]  Cd Length: 278  Bit Score: 280.51  E-value: 1.98e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842   8 DLLDGQALSQAVRDEVKADIQAWTDDH-RPPFLSAVLVGDNPASKAYVRGKEKDAAEVGIETETHHLDADTSQSELLDLV 86
Cdd:PRK14172   3 QIINGKEVALKIKEEIKNFVEERKENGlSIPKIASILVGNDGGSIYYMNNQEKVANSLGIDFKKIKLDESISEEDLINEI 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842  87 HDLNADASVDGILVQLPLPDHVDERTVIDAVDPSKDVDGFHPENLGRLMRGTPRYIPATPYGIMEMLSRSDIDPESMDAV 166
Cdd:PRK14172  83 EELNKDNNVHGIMLQLPLPKHLDEKKITNKIDANKDIDCLTFISVGKFYKGEKCFLPCTPNSVITLIKSLNIDIEGKEVV 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842 167 IVGRSNIVGKPLANLLLRRtaNATVTVCHSRTKDLAAHTRRADLLVAAAGQAAFIDADMVKEDAVVIDVGINRVDDpstd 246
Cdd:PRK14172 163 VIGRSNIVGKPVAQLLLNE--NATVTICHSKTKNLKEVCKKADILVVAIGRPKFIDEEYVKEGAIVIDVGTSSVNG---- 236

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 499723842 247 rgyRLVGDVDFEGVRPKARRITPVPGGVGLMTRAMLLKNTLKA 289
Cdd:PRK14172 237 ---KITGDVNFDKVIDKASYITPVPGGVGSLTTTLLIKNVCEA 276
PRK14175 PRK14175
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...
 7-293 2.93e-94

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;


Pssm-ID: 184552 [Multi-domain]  Cd Length: 286  Bit Score: 280.26  E-value: 2.93e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842   7 ADLLDGQALSQAVRDEVKADIQAWTDDHRPPFLSAVLVGDNPASKAYVRGKEKDAAEVGIETETHHLDADTSQSELLDLV 86
Cdd:PRK14175   3 AKILDGKQIAKDYRQGLQDQVEALKEKGFTPKLSVILVGNDGASQSYVRSKKKAAEKIGMISEIVHLEETATEEEVLNEL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842  87 HDLNADASVDGILVQLPLPDHVDERTVIDAVDPSKDVDGFHPENLGRLMRGTPRYIPATPYGIMEMLSRSDIDPESMDAV 166
Cdd:PRK14175  83 NRLNNDDSVSGILVQVPLPKQVSEQKILEAINPEKDVDGFHPINIGKLYIDEQTFVPCTPLGIMEILKHADIDLEGKNAV 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842 167 IVGRSNIVGKPLANLLLRrtANATVTVCHSRTKDLAAHTRRADLLVAAAGQAAFIDADMVKEDAVVIDVGiNRVDDPStd 246
Cdd:PRK14175 163 VIGRSHIVGQPVSKLLLQ--KNASVTILHSRSKDMASYLKDADVIVSAVGKPGLVTKDVVKEGAVIIDVG-NTPDENG-- 237

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 499723842 247 rgyRLVGDVDFEGVRPKARRITPVPGGVGLMTRAMLLKNTLKAARLR 293
Cdd:PRK14175 238 ---KLKGDVDYDAVKEIAGAITPVPGGVGPLTITMVLNNTLLAEKMR 281
PRK14169 PRK14169
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...
 7-294 3.56e-94

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;


Pssm-ID: 184550 [Multi-domain]  Cd Length: 282  Bit Score: 279.91  E-value: 3.56e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842   7 ADLLDGQALSQAVRDEVKADIQAWTDDHRPPFLSAVLVGDNPASKAYVRGKEKDAAEVGIETETHHLDADTSQSELLDLV 86
Cdd:PRK14169   1 ATRLDGRAVSKKILADLKQTVAKLAQQDVTPTLAVVLVGSDPASEVYVRNKQRRAEDIGVRSLMFRLPEATTQADLLAKV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842  87 HDLNADASVDGILVQLPLPDHVDERTVIDAVDPSKDVDGFHPENLGRLMRGTPRYIPATPYGIMEMLSRSDIDPESMDAV 166
Cdd:PRK14169  81 AELNHDPDVDAILVQLPLPAGLDEQAVIDAIDPDKDVDGFSPVSVGRLWANEPTVVASTPYGIMALLDAYDIDVAGKRVV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842 167 IVGRSNIVGKPLANLLLrrTANATVTVCHSRTKDLAAHTRRADLLVAAAGQAAFIDADMVKEDAVVIDVGINRVDDPStd 246
Cdd:PRK14169 161 IVGRSNIVGRPLAGLMV--NHDATVTIAHSKTRNLKQLTKEADILVVAVGVPHFIGADAVKPGAVVIDVGISRGADGK-- 236

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 499723842 247 rgyrLVGDVDFEGVRPKARRITPVPGGVGLMTRAMLLKNTLKAARLRA 294
Cdd:PRK14169 237 ----LLGDVDEAAVAPIASAITPVPGGVGPMTIASLMAQTVTLAKRRA 280
PLN02616 PLN02616
tetrahydrofolate dehydrogenase/cyclohydrolase, putative
 7-291 1.93e-93

tetrahydrofolate dehydrogenase/cyclohydrolase, putative


Pssm-ID: 215332 [Multi-domain]  Cd Length: 364  Bit Score: 281.12  E-value: 1.93e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842   7 ADLLDGQALSQAVRDEVKADIQAWTDD-HRPPFLSAVLVGDNPASKAYVRGKEKDAAEVGIETETHHLDADTSQSELLDL 85
Cdd:PLN02616  73 AKVIDGKAVAKKIRDEITIEVSRMKESiGVVPGLAVILVGDRKDSATYVRNKKKACDSVGINSFEVRLPEDSTEQEVLKF 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842  86 VHDLNADASVDGILVQLPLPDHVDERTVIDAVDPSKDVDGFHPENLGRL-MRG-TPRYIPATPYGIMEMLSRSDIDPESM 163
Cdd:PLN02616 153 ISGFNNDPSVHGILVQLPLPSHMDEQNILNAVSIEKDVDGFHPLNIGRLaMRGrEPLFVPCTPKGCIELLHRYNVEIKGK 232

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842 164 DAVIVGRSNIVGKPLAnLLLRRTaNATVTVCHSRTKDLAAHTRRADLLVAAAGQAAFIDADMVKEDAVVIDVGINRVDDP 243
Cdd:PLN02616 233 RAVVIGRSNIVGMPAA-LLLQRE-DATVSIVHSRTKNPEEITREADIIISAVGQPNMVRGSWIKPGAVVIDVGINPVEDA 310

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 499723842 244 STDRGYRLVGDVDFEGVRPKARRITPVPGGVGLMTRAMLLKNTLKAAR 291
Cdd:PLN02616 311 SSPRGYRLVGDVCYEEACKVASAVTPVPGGVGPMTIAMLLSNTLTSAK 358
PRK14178 PRK14178
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...
 9-293 2.66e-93

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;


Pssm-ID: 172666 [Multi-domain]  Cd Length: 279  Bit Score: 277.49  E-value: 2.66e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842   9 LLDGQALSQAVRDEVKADIQawtDDHRPPFLSAVLVGDNPASKAYVRGKEKDAAEVGIETETHHLDADTSQSELLDLVHD 88
Cdd:PRK14178   2 ILDGKAVSEKRLELLKEEII---ESGLYPRLATVIVGDDPASQMYVRMKHRACERVGIGSVGIELPGDATTRTVLERIRR 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842  89 LNADASVDGILVQLPLPDHVDERTVIDAVDPSKDVDGFHPENLGRLMRGTPRYIPATPYGIMEMLSRSDIDPESMDAVIV 168
Cdd:PRK14178  79 LNEDPDINGILVQLPLPKGVDTERVIAAILPEKDVDGFHPLNLGRLVSGLPGFAPCTPNGIMTLLHEYKISIAGKRAVVV 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842 169 GRSNIVGKPLANLLLRrtANATVTVCHSRTKDLAAHTRRADLLVAAAGQAAFIDADMVKEDAVVIDVGINRVDDpstdrg 248
Cdd:PRK14178 159 GRSIDVGRPMAALLLN--ADATVTICHSKTENLKAELRQADILVSAAGKAGFITPDMVKPGATVIDVGINQVNG------ 230

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 499723842 249 yRLVGDVDFEGVRPKARRITPVPGGVGLMTRAMLLKNTLKAARLR 293
Cdd:PRK14178 231 -KLCGDVDFDAVKEIAGAITPVPGGVGPMTIATLMENTFDAAKMR 274
THF_DHG_CYH_C pfam02882
Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain;
127-294 3.72e-93

Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain;


Pssm-ID: 427036  Cd Length: 160  Bit Score: 272.80  E-value: 3.72e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842  127 HPENLGRLMRGTPRYIPATPYGIMEMLSRSDIDPESMDAVIVGRSNIVGKPLANLLLRrtANATVTVCHSRTKDLAAHTR 206
Cdd:pfam02882   1 HPYNLGRLVLGKPCFVPCTPRGIMELLKRYGIDLAGKNVVVVGRSNIVGKPLALLLLN--ANATVTVCHSKTKDLAEITR 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842  207 RADLLVAAAGQAAFIDADMVKEDAVVIDVGINRVDdpstdrGYRLVGDVDFEGVRPKARRITPVPGGVGLMTRAMLLKNT 286
Cdd:pfam02882  79 EADIVVVAVGKPELIKADWIKPGAVVIDVGINRVG------NGKLVGDVDFENVKEKASAITPVPGGVGPMTVAMLLQNT 152


                  ....*...
gi 499723842  287 LKAARLRA 294
Cdd:pfam02882 153 VEAAKRQL 160
PRK14168 PRK14168
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...
 7-291 2.15e-92

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;


Pssm-ID: 237633 [Multi-domain]  Cd Length: 297  Bit Score: 275.99  E-value: 2.15e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842   7 ADLLDGQALSQAVRDEVKADIQAWTDDH-RPPFLSAVLVGDNPASKAYVRGKEKDAAEVGIETETHHLDADTSQSELLDL 85
Cdd:PRK14168   3 AKIIKGTEIREEILEEIRGEVAELKEKYgKVPGLVTILVGESPASLSYVTLKIKTAHRLGFHEIQDNQSVDITEEELLAL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842  86 VHDLNADASVDGILVQLPLPDHVDERTVIDAVDPSKDVDGFHPENLGRLMRGTP--RYIPATPYGIMEMLSRSDIDPESM 163
Cdd:PRK14168  83 IDKYNNDDSIHGILVQLPLPKHINEKKVLNAIDPDKDVDGFHPVNVGRLMIGGDevKFLPCTPAGIQEMLVRSGVETSGA 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842 164 DAVIVGRSNIVGKPLANLLLRRT--ANATVTVCHSRTKDLAAHTRRADLLVAAAGQAAFIDADMVKEDAVVIDVGINRVD 241
Cdd:PRK14168 163 EVVVVGRSNIVGKPIANMMTQKGpgANATVTIVHTRSKNLARHCQRADILIVAAGVPNLVKPEWIKPGATVIDVGVNRVG 242

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 499723842 242 DPSTDRGYRLVGDVDFEGVRPKARRITPVPGGVGLMTRAMLLKNTLKAAR 291
Cdd:PRK14168 243 TNESTGKAILSGDVDFDAVKEIAGKITPVPGGVGPMTIAMLMRNTLKSAK 292
PRK14171 PRK14171
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...
 8-289 5.26e-90

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;


Pssm-ID: 172659 [Multi-domain]  Cd Length: 288  Bit Score: 269.52  E-value: 5.26e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842   8 DLLDGQALSQAVRDEVKADIQAWTDD-HRPPFLSAVLVGDNPASKAYVRGKEKDAAEVGIETETHHLDADTSQSELLDLV 86
Cdd:PRK14171   3 NIIDGKALANEILADLKLEIQELKSQtNASPKLAIVLVGDNPASIIYVKNKIKNAHKIGIDTLLVNLSTTIHTNDLISKI 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842  87 HDLNADASVDGILVQLPLPDHVDERTVIDAVDPSKDVDGFHPENLGRLMRGTPR-YIPATPYGIMEMLSRSDIDPESMDA 165
Cdd:PRK14171  83 NELNLDNEISGIIVQLPLPSSIDKNKILSAVSPSKDIDGFHPLNVGYLHSGISQgFIPCTALGCLAVIKKYEPNLTGKNV 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842 166 VIVGRSNIVGKPLANLLLRRtaNATVTVCHSRTKDLAAHTRRADLLVAAAGQAAFIDADMVKEDAVVIDVGINRVDdpst 245
Cdd:PRK14171 163 VIIGRSNIVGKPLSALLLKE--NCSVTICHSKTHNLSSITSKADIVVAAIGSPLKLTAEYFNPESIVIDVGINRIS---- 236

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 499723842 246 drGYRLVGDVDFEGVRPKARRITPVPGGVGLMTRAMLLKNTLKA 289
Cdd:PRK14171 237 --GNKIIGDVDFENVKSKVKYITPVPGGIGPMTIAFLLKNTVKA 278
PRK14187 PRK14187
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...
 7-294 2.66e-89

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;


Pssm-ID: 172675 [Multi-domain]  Cd Length: 294  Bit Score: 267.85  E-value: 2.66e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842   7 ADLLDGQALSQAVRDEVKADIQAWTDDHR-PPFLSAVLVGDNPASKAYVRGKEKDAAEVGIETETHHLDADTSQSELLDL 85
Cdd:PRK14187   2 TNIIDGKKIANDITEILATCIDDLKRQHNlFPCLIVILVGDDPASQLYVRNKQRKAEMLGLRSETILLPSTISESSLIEK 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842  86 VHDLNADASVDGILVQLPLPDHVDERTVIDAVDPSKDVDGFHPENLGRLMRGTPR--YIPATPYGIMEMLSRSDIDPESM 163
Cdd:PRK14187  82 INELNNDDSVHGILVQLPVPNHIDKNLIINTIDPEKDVDGFHNENVGRLFTGQKKncLIPCTPKGCLYLIKTITRNLSGS 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842 164 DAVIVGRSNIVGKPLANLLLRRtaNATVTVCHSRTKDLAAHTRRADLLVAAAGQAAFIDADMVKEDAVVIDVGINRVddp 243
Cdd:PRK14187 162 DAVVIGRSNIVGKPMACLLLGE--NCTVTTVHSATRDLADYCSKADILVAAVGIPNFVKYSWIKKGAIVIDVGINSI--- 236

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 499723842 244 STDRGYRLVGDVDFEGVRPKARRITPVPGGVGLMTRAMLLKNTLKAARLRA 294
Cdd:PRK14187 237 EEGGVKKFVGDVDFAEVKKKASAITPVPGGVGPMTIAFLMVNTVIAACNQK 287
PRK14181 PRK14181
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...
 9-286 2.54e-88

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;


Pssm-ID: 172669 [Multi-domain]  Cd Length: 287  Bit Score: 265.19  E-value: 2.54e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842   9 LLDGQALSQAVRDEVKADIQAWTddhRPPFLSAVLVGDNPASKAYVRGKEKDAAEVGIETETHHLDADTSQSELLDLVHD 88
Cdd:PRK14181   2 LLKGAPAAEHILATIKENISASS---TAPGLAVVLIGNDPASEVYVGMKVKKATDLGMVSKAHRLPSDATLSDILKLIHR 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842  89 LNADASVDGILVQLPLPDHVDERTVIDAVDPSKDVDGFHPENLGRLMRG-TPRYIPATPYGIMEMLSRSDIDPESMDAVI 167
Cdd:PRK14181  79 LNNDPNIHGILVQLPLPKHLDAQAILQAISPDKDVDGLHPVNMGKLLLGeTDGFIPCTPAGIIELLKYYEIPLHGRHVAI 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842 168 VGRSNIVGKPLANLLLRR--TANATVTVCHSRTKDLAAHTRRADLLVAAAGQAAFIDADMVKEDAVVIDVGINRVdDPST 245
Cdd:PRK14181 159 VGRSNIVGKPLAALLMQKhpDTNATVTLLHSQSENLTEILKTADIIIAAIGVPLFIKEEMIAEKAVIVDVGTSRV-PAAN 237

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 499723842 246 DRGYRLVGDVDFEGVRPKARRITPVPGGVGLMTRAMLLKNT 286
Cdd:PRK14181 238 PKGYILVGDVDFNNVVPKCRAITPVPGGVGPMTVAMLMRNT 278
PRK14180 PRK14180
bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...
 9-291 9.03e-85

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional


Pssm-ID: 172668 [Multi-domain]  Cd Length: 282  Bit Score: 256.11  E-value: 9.03e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842   9 LLDGQALSQAVRDEVKADIQAWTDDHR-PPFLSAVLVGDNPASKAYVRGKEKDAAEVGIETETHHLDADTSQSELLDLVH 87
Cdd:PRK14180   3 LIDGKSLSKDLKERLATQVQEYKHHTAiTPKLVAIIVGNDPASKTYVASKEKACAQVGIDSQVITLPEHTTESELLELID 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842  88 DLNADASVDGILVQLPLPDHVDERTVIDAVDPSKDVDGFHPENLGRL-MRGTPRYIPATPYGIMEMLSRSDIDPESMDAV 166
Cdd:PRK14180  83 QLNNDSSVHAILVQLPLPAHINKNNVIYSIKPEKDVDGFHPTNVGRLqLRDKKCLESCTPKGIMTMLREYGIKTEGAYAV 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842 167 IVGRSNIVGKPLANLLLrrTANATVTVCHSRTKDLAAHTRRADLLVAAAGQAAFIDADMVKEDAVVIDVGINRVDDpstd 246
Cdd:PRK14180 163 VVGASNVVGKPVSQLLL--NAKATVTTCHRFTTDLKSHTTKADILIVAVGKPNFITADMVKEGAVVIDVGINHVDG---- 236

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 499723842 247 rgyRLVGDVDFEGVRPKARRITPVPGGVGLMTRAMLLKNTLKAAR 291
Cdd:PRK14180 237 ---KIVGDVDFAAVKDKVAAITPVPGGVGPMTITELLYNTFQCAQ 278
PRK14170 PRK14170
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...
 7-291 1.34e-83

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;


Pssm-ID: 172658 [Multi-domain]  Cd Length: 284  Bit Score: 253.07  E-value: 1.34e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842   7 ADLLDGQALSQAVRDEVKADIQAWTDDHRPPFLSAVLVGDNPASKAYVRGKEKDAAEVGIETETHHLDADTSQSELLDLV 86
Cdd:PRK14170   2 GEIIDGKKLAKEIQEKVTREVAELVKEGKKPGLAVVLVGDNQASRTYVRNKQKRTEEAGMKSVLIELPENVTEEKLLSVV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842  87 HDLNADASVDGILVQLPLPDHVDERTVIDAVDPSKDVDGFHPENLGRLMRGTPRYIPATPYGIMEMLSRSDIDPESMDAV 166
Cdd:PRK14170  82 EELNEDKTIHGILVQLPLPEHISEEKVIDTISYDKDVDGFHPVNVGNLFIGKDSFVPCTPAGIIELIKSTGTQIEGKRAV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842 167 IVGRSNIVGKPLANLLLrrTANATVTVCHSRTKDLAAHTRRADLLVAAAGQAAFIDADMVKEDAVVIDVGINRvddpstD 246
Cdd:PRK14170 162 VIGRSNIVGKPVAQLLL--NENATVTIAHSRTKDLPQVAKEADILVVATGLAKFVKKDYIKPGAIVIDVGMDR------D 233

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 499723842 247 RGYRLVGDVDFEGVRPKARRITPVPGGVGLMTRAMLLKNTLKAAR 291
Cdd:PRK14170 234 ENNKLCGDVDFDDVVEEAGFITPVPGGVGPMTITMLLANTLKAAK 278
PLN02897 PLN02897
tetrahydrofolate dehydrogenase/cyclohydrolase, putative
 6-291 8.62e-82

tetrahydrofolate dehydrogenase/cyclohydrolase, putative


Pssm-ID: 178485 [Multi-domain]  Cd Length: 345  Bit Score: 250.65  E-value: 8.62e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842   6 DADLLDGQALSQAVRDEVKADIQAWTDD-HRPPFLSAVLVGDNPASKAYVRGKEKDAAEVGIETETHHLDADTSQSELLD 84
Cdd:PLN02897  55 KTVVIDGNVIAEEIRTKIASEVRKMKKAvGKVPGLAVVLVGQQRDSQTYVRNKIKACEETGIKSLLAELPEDCTEGQILS 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842  85 LVHDLNADASVDGILVQLPLPDHVDERTVIDAVDPSKDVDGFHPENLGRL-MRG-TPRYIPATPYGIMEMLSRSDIDPES 162
Cdd:PLN02897 135 ALRKFNEDTSIHGILVQLPLPQHLDESKILNMVRLEKDVDGFHPLNVGNLaMRGrEPLFVSCTPKGCVELLIRSGVEIAG 214

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842 163 MDAVIVGRSNIVGKPLANLLLRRtaNATVTVCHSRTKDLAAHTRRADLLVAAAGQAAFIDADMVKEDAVVIDVGINRVDD 242
Cdd:PLN02897 215 KNAVVIGRSNIVGLPMSLLLQRH--DATVSTVHAFTKDPEQITRKADIVIAAAGIPNLVRGSWLKPGAVVIDVGTTPVED 292

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 499723842 243 PSTDRGYRLVGDVDFEGVRPKARRITPVPGGVGLMTRAMLLKNTLKAAR 291
Cdd:PLN02897 293 SSCEFGYRLVGDVCYEEALGVASAITPVPGGVGPMTITMLLCNTLDAAK 341
PRK14177 PRK14177
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...
 9-291 1.27e-79

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;


Pssm-ID: 172665 [Multi-domain]  Cd Length: 284  Bit Score: 242.96  E-value: 1.27e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842   9 LLDGQALSQAVRDEVKADI-QAWTDDHRPPFLSAVLVGDNPASKAYVRGKEKDAAEVGIETETHHLDADTSQSELLDLVH 87
Cdd:PRK14177   5 LLDGKKLSEKIRNEIRETIeERKTKNKRIPKLATILVGNNPASETYVSMKVKACHKVGMGSEMIRLKEQTTTEELLGVID 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842  88 DLNADASVDGILVQLPLPDHVDERTVIDAVDPSKDVDGFHPENLGRLMRGTPRYIPATPYGIMEMLSRSDIDPESMDAVI 167
Cdd:PRK14177  85 KLNLDPNVDGILLQHPVPSQIDERAAFDRIALEKDVDGVTTLSFGKLSMGVETYLPCTPYGMVLLLKEYGIDVTGKNAVV 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842 168 VGRSNIVGKPLANLLLRrtANATVTVCHSRTKDLAAHTRRADLLVAAAGQAAFIDADMVKEDAVVIDVGINrvddPSTdr 247
Cdd:PRK14177 165 VGRSPILGKPMAMLLTE--MNATVTLCHSKTQNLPSIVRQADIIVGAVGKPEFIKADWISEGAVLLDAGYN----PGN-- 236

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 499723842 248 gyrlVGDVDFEGVRPKARRITPVPGGVGLMTRAMLLKNTLKAAR 291
Cdd:PRK14177 237 ----VGDIEISKAKDKSSFYTPVPGGVGPMTIAVLLLQTLYSFK 276
PRK14192 PRK14192
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...
 7-290 4.12e-79

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;


Pssm-ID: 184561 [Multi-domain]  Cd Length: 283  Bit Score: 241.67  E-value: 4.12e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842   7 ADLLDGQALSQAVRDEVKADIQAWTDDH-RPPFLSAVLVGDNPASKAYVRGKEKDAAEVGIETETHHLDADTSQSELLDL 85
Cdd:PRK14192   3 ALVLDGKALAKQIEEELSVRVEALKAKTgRTPILATILVGDDPASATYVRMKGNACRRVGMDSLKVELPQETTTEQLLAK 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842  86 VHDLNADASVDGILVQLPLPDHVDERTVIDAVDPSKDVDGFHPENLGRLMRGTPRYIPATPYGIMEMLSRSDIDPESMDA 165
Cdd:PRK14192  83 IEELNANPDVHGILLQHPVPAQIDERACFDAISLAKDVDGVTCLGFGRMAMGEAAYGSATPAGIMRLLKAYNIELAGKHA 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842 166 VIVGRSNIVGKPLANLLLrrTANATVTVCHSRTKDLAAHTRRADLLVAAAGQAAFIDADMVKEDAVVIDVGINrvddPST 245
Cdd:PRK14192 163 VVVGRSAILGKPMAMMLL--NANATVTICHSRTQNLPELVKQADIIVGAVGKPELIKKDWIKQGAVVVDAGFH----PRD 236

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 499723842 246 DRGyrlVGDVDFEGVRPKARRITPVPGGVGLMTRAMLLKNTLKAA 290
Cdd:PRK14192 237 GGG---VGDIELQGIEEIASAYTPVPGGVGPMTINTLIRQTVEAA 278
THF_DHG_CYH pfam00763
Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain;
10-124 4.04e-58

Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain;


Pssm-ID: 459930 [Multi-domain]  Cd Length: 115  Bit Score: 181.83  E-value: 4.04e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842   10 LDGQALSQAVRDEVKADIQAWTDDHRPPFLSAVLVGDNPASKAYVRGKEKDAAEVGIETETHHLDADTSQSELLDLVHDL 89
Cdd:pfam00763   1 IDGKAIAKKIREELKEEVAALKAGGRKPGLAVILVGDDPASQVYVRNKKKACEEVGIESELIRLPEDTTEEELLALIDKL 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 499723842   90 NADASVDGILVQLPLPDHVDERTVIDAVDPSKDVD 124
Cdd:pfam00763  81 NADPSVHGILVQLPLPKHIDEEKVLEAIDPEKDVD 115
NAD_bind_m-THF_DH_Cyclohyd_like cd05212
NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and ...
 142-291 1.01e-24

NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; NAD(P) binding domains of methylene-tetrahydrofolate dehydrogenase (m-THF DH) and m-THF DH/cyclohydrolase bifunctional enzymes (m-THF DH/cyclohydrolase). M-THF is a versatile carrier of activated one-carbon units. The major one-carbon folate donors are N-5 methyltetrahydrofolate, N5,N10-m-THF, and N10-formayltetrahydrofolate. The oxidation of metabolic intermediate m-THF to m-THF requires the enzyme m-THF DH. In addition, most DHs also have an associated cyclohydrolase activity which catalyzes its hydrolysis to N10-formyltetrahydrofolate. m-THF DH is typically found as part of a multifunctional protein in eukaryotes. NADP-dependent m-THF DH in mammals, birds and yeast are components of a trifunctional enzyme with DH, cyclohydrolase, and synthetase activities. Certain eukaryotic cells also contain homodimeric bifunctional DH/cyclodrolase form. In bacteria, mono-functional DH, as well as bifunctional DH/cyclodrolase are found. In addition, yeast (S. cerevisiae) also express a monofunctional DH. M-THF DH, like other amino acid DH-like NAD(P)-binding domains, is a member of the Rossmann fold superfamily which includes glutamate, leucine, and phenylalanine DHs, m-THF DH, methylene-tetrahydromethanopterin DH, m-THF DH/cyclohydrolase, Shikimate DH-like proteins, malate oxidoreductases, and glutamyl tRNA reductase. Amino acid DHs catalyze the deamination of amino acids to keto acids with NAD(P)+ as a cofactor. The NAD(P)-binding Rossmann fold superfamily includes a wide variety of protein families including NAD(P)- binding domains of alcohol DHs, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate DH, lactate/malate DHs, formate/glycerate DHs, siroheme synthases, 6-phosphogluconate DH, amino acid DHs, repressor rex, NAD-binding potassium channel domain, CoA-binding, and ornithine cyclodeaminase-like domains. These domains have an alpha-beta-alpha configuration. NAD binding involves numerous hydrogen and van der Waals contacts.


Pssm-ID: 133451  Cd Length: 140  Bit Score: 96.42  E-value: 1.01e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842 142 IPATPYGI-------MEMLSRSDIDPESMDAVIVGRSNIVGKPLANLLLRRtaNATVTVCHSRTKDLAAHTRRADLLVAA 214
Cdd:cd05212    1 GPCTPLFVspvakavKELLNKEGVRLDGKKVLVVGRSGIVGAPLQCLLQRD--GATVYSCDWKTIQLQSKVHDADVVVVG 78

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 499723842 215 AGQAAFIDADMVKEDAVVIDVGINRVDDpstdrgyrlvgdvdfEGVRPKARRITPVPGGVGLMTRAMLLKNTLKAAR 291
Cdd:cd05212   79 SPKPEKVPTEWIKPGATVINCSPTKLSG---------------DDVKESASLYVPMTGGVGKLTVAMRMQNMVRSVR 140
NAD_bind_m-THF_DH cd01079
NAD binding domain of methylene-tetrahydrofolate dehydrogenase; The NAD-binding domain of ...
 119-288 2.80e-06

NAD binding domain of methylene-tetrahydrofolate dehydrogenase; The NAD-binding domain of methylene-tetrahydrofolate dehydrogenase (m-THF DH). M-THF is a versatile carrier of activated one-carbon units. The major one-carbon folate donors are N-5 methyltetrahydrofolate, N5,N10-m-THF, and N10-formayltetrahydrofolate. The oxidation of metabolic intermediate m-THF to m-THF requires the enzyme m-THF DH. M-THF DH is a component of an unusual monofunctional enzyme; in eukaryotes, m-THF DH is typically found as part of a multifunctional protein. NADP-dependent m-THF DHs in mammals, birds and yeast are components of a trifunctional enzyme with DH, cyclohydrolase, and synthetase activities. Certain eukaryotic cells also contain homodimeric bifunctional DH/cyclodrolase form. In bacteria, monofunctional DH, as well as bifunctional DH/cyclodrolase are found. In addition, yeast (S. cerevisiae) also express an monofunctional DH. This family contains only the monofunctional DHs from S. cerevisiae and certain bacteria. M-THF DH, like other amino acid DH-like NAD(P)-binding domains, is a member of the Rossmann fold superfamily which includes glutamate, leucine, and phenylalanine DHs, m-THF DH, methylene-tetrahydromethanopterin DH, m-THF DH/cyclohydrolase, Shikimate DH-like proteins, malate oxidoreductases, and glutamyl tRNA reductase. Amino acid DHs catalyze the deamination of amino acids to keto acids with NAD(P)+ as a cofactor. The NAD(P)-binding Rossmann fold superfamily includes a wide variety of protein families including NAD(P)- binding domains of alcohol DHs, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate DH, lactate/malate DHs, formate/glycerate DHs, siroheme synthases, 6-phosphogluconate DH, amino acid DHs, repressor rex, NAD-binding potassium channel domain, CoA-binding, and ornithine cyclodeaminase-like domains. These domains have an alpha-beta-alpha configuration. NAD binding involves numerous hydrogen and van der Waals contacts.


Pssm-ID: 133447 [Multi-domain]  Cd Length: 197  Bit Score: 47.04  E-value: 2.80e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842 119 PSKDVDGFHPENLG------RLMRGTPRY---IPATPYGIMEMLSRSDIDPESM---------DAVIVGRSNIVGKPLAN 180
Cdd:cd01079    1 PHKDVEGLSHKYIFnlyhniRFLDPENRKksiLPCTPLAIVKILEFLGIYNKILpygnrlygkTITIINRSEVVGRPLAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499723842 181 LLlrrtANATVTV---------CHSRTKDLAAHTR--------------RADLLVAAAGQAAF-IDADMVKEDAVVIDVG 236
Cdd:cd01079   81 LL----ANDGARVysvdingiqVFTRGESIRHEKHhvtdeeamtldclsQSDVVITGVPSPNYkVPTELLKDGAICINFA 156

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 499723842 237 INRVDDPStdrgyrlvgdvdfegVRPKARRITPVpggVGLMTRAMLLKNTLK 288
Cdd:cd01079  157 SIKNFEPS---------------VKEKASIYVPS---IGKVTIAMLLRNLLR 190
COG5322 COG5322
Predicted amino acid dehydrogenase [General function prediction only];
168-236 2.47e-03

Predicted amino acid dehydrogenase [General function prediction only];


Pssm-ID: 444114 [Multi-domain]  Cd Length: 362  Bit Score: 39.05  E-value: 2.47e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 499723842 168 VGRSNIVGKPLANLL-----LRRTANATVTVchsrTKDLAAHTRRADLLVAAAGQA-AFIDADMVKEDAVVIDVG 236
Cdd:COG5322  175 VKRLTLVARNLERLEelaeeILRNPGGKVTI----TTDIDEALREADIVVTVTSAVgAIIDPEDLKPGAVVCDVA 245
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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