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Conserved domains on  [gi|499736863|ref|WP_011417597|]
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lytic transglycosylase domain-containing protein [Syntrophus aciditrophicus]

Protein Classification

lytic transglycosylase domain-containing protein( domain architecture ID 12989917)

lytic transglycosylase domain-containing protein similar to phage exolysin that catalyzes the cleavage of the host peptidoglycans during virus entry

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LT_IagB-like cd13400
Escherichia coli invasion protein IagB and similar proteins; Lytic transglycosylase-like ...
 31-136 6.76e-57

Escherichia coli invasion protein IagB and similar proteins; Lytic transglycosylase-like protein, similar to Escherichia coli invasion protein IagB. IagB is encoded within a pathogenicity island in Salmonella enterica and has been shown to degrade polymeric peptidoglycan. IagB-like invasion proteins are implicated in the invasion of eukaryotic host cells by bacteria. Lytic transglycosylase (LT) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Members of this family resemble the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda.


:

Pssm-ID: 381603 [Multi-domain]  Cd Length: 109  Bit Score: 172.33  E-value: 6.76e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499736863  31 YNVSPRLLWAIARVESGFRPGALNRNADGSYDYGLMQINSSWARVVGKELWSS---LGDPCTNVKVGAWILSDCIRKHGY 107
Cdd:cd13400    1 YGVPPRLLRAIAKVESGFNPNAINRNKNGSYDIGLMQINSIWLPELARYGITReelLNDPCTNIYVGAWILARNIKRYGN 80

                         90       100
                 ....*....|....*....|....*....
gi 499736863 108 TWEAVGAYNASQKHKRARYARKVYTALRK 136
Cdd:cd13400   81 TWKAVGAYNSGTPKKNDKYARKVYRIYRR 109
 
Name Accession Description Interval E-value
LT_IagB-like cd13400
Escherichia coli invasion protein IagB and similar proteins; Lytic transglycosylase-like ...
 31-136 6.76e-57

Escherichia coli invasion protein IagB and similar proteins; Lytic transglycosylase-like protein, similar to Escherichia coli invasion protein IagB. IagB is encoded within a pathogenicity island in Salmonella enterica and has been shown to degrade polymeric peptidoglycan. IagB-like invasion proteins are implicated in the invasion of eukaryotic host cells by bacteria. Lytic transglycosylase (LT) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Members of this family resemble the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda.


Pssm-ID: 381603 [Multi-domain]  Cd Length: 109  Bit Score: 172.33  E-value: 6.76e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499736863  31 YNVSPRLLWAIARVESGFRPGALNRNADGSYDYGLMQINSSWARVVGKELWSS---LGDPCTNVKVGAWILSDCIRKHGY 107
Cdd:cd13400    1 YGVPPRLLRAIAKVESGFNPNAINRNKNGSYDIGLMQINSIWLPELARYGITReelLNDPCTNIYVGAWILARNIKRYGN 80

                         90       100
                 ....*....|....*....|....*....
gi 499736863 108 TWEAVGAYNASQKHKRARYARKVYTALRK 136
Cdd:cd13400   81 TWKAVGAYNSGTPKKNDKYARKVYRIYRR 109
PRK15328 PRK15328
type III secretion system invasion protein IagB;
1-136 3.90e-39

type III secretion system invasion protein IagB;


Pssm-ID: 185228 [Multi-domain]  Cd Length: 160  Bit Score: 129.21  E-value: 3.90e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499736863   1 MKKVVVLFSLLFLFPAGQlhAFCFEEAGSIYNVSPRLLWAIARVESGFRPGALNRNADGSYDYGLMQINSSW---ARVVG 77
Cdd:PRK15328   1 MHYFFIIVIWLLSINTAW--ADCWLQAEKMFNIESELLYAIAQQESAMKPGAIGHNRDGSTDLGLMQINSFHmkrLKKMG 78

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 499736863  78 KELWSSLGDPCTNVKVGAWILSDCIRKHGYTWEAVGAYNASQKHKRA----RYARKVYTALRK 136
Cdd:PRK15328  79 ISEKQLLQDPCISVIVGASILSDMMKIYGYSWEAVGAYNAGTSPKRSdirkRYAKKIWENYRK 141
SLT pfam01464
Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found ...
 24-117 4.75e-23

Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found in phages, type II, type III and type IV secretion systems.


Pssm-ID: 396169 [Multi-domain]  Cd Length: 114  Bit Score: 86.59  E-value: 4.75e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499736863   24 FEEAGSIYNVSPRLLWAIARVESGFRPGALNRnadgSYDYGLMQINSSWARVVGKELWSS---LGDPCTNVKVGAWILSD 100
Cdd:pfam01464   1 IIKAAQKYGVDPSLLLAIAQQESGFNPKAVSK----SGAVGLMQIMPSTAKRLGLRVNPGvddLFDPEKNIKAGTKYLKE 76

                          90
                  ....*....|....*...
gi 499736863  101 CIRKHG-YTWEAVGAYNA 117
Cdd:pfam01464  77 LYKQYGgDLWLALAAYNA 94
MltE COG0741
Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin ...
 24-117 6.48e-16

Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin domain) [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440504 [Multi-domain]  Cd Length: 244  Bit Score: 71.18  E-value: 6.48e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499736863  24 FEEAGSIYNVSPRLLWAIARVESGFRPGALNR-NAdgsydYGLMQINSSWARVVGKEL-----WSSLGDPCTNVKVGAWI 97
Cdd:COG0741  107 IEEAAKKYGVDPALVLALIRQESAFNPNAVSPaGA-----RGLMQLMPATARRLGLKLglgpsPDDLFDPETNIRAGAAY 181

                         90       100
                 ....*....|....*....|.
gi 499736863  98 LSDCIRKHGYTWE-AVGAYNA 117
Cdd:COG0741  182 LRELLDRFDGDLVlALAAYNA 202
LYZ1 smart00263
Alpha-lactalbumin / lysozyme C;
41-72 9.81e-07

Alpha-lactalbumin / lysozyme C;


Pssm-ID: 197612  Cd Length: 127  Bit Score: 44.59  E-value: 9.81e-07
                           10        20        30
                   ....*....|....*....|....*....|..
gi 499736863    41 IARVESGFRPGALNRNADGSYDYGLMQINSSW 72
Cdd:smart00263  31 LAFHESGYNTQATNYNNGGSTDYGIFQINSKY 62
 
Name Accession Description Interval E-value
LT_IagB-like cd13400
Escherichia coli invasion protein IagB and similar proteins; Lytic transglycosylase-like ...
 31-136 6.76e-57

Escherichia coli invasion protein IagB and similar proteins; Lytic transglycosylase-like protein, similar to Escherichia coli invasion protein IagB. IagB is encoded within a pathogenicity island in Salmonella enterica and has been shown to degrade polymeric peptidoglycan. IagB-like invasion proteins are implicated in the invasion of eukaryotic host cells by bacteria. Lytic transglycosylase (LT) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Members of this family resemble the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda.


Pssm-ID: 381603 [Multi-domain]  Cd Length: 109  Bit Score: 172.33  E-value: 6.76e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499736863  31 YNVSPRLLWAIARVESGFRPGALNRNADGSYDYGLMQINSSWARVVGKELWSS---LGDPCTNVKVGAWILSDCIRKHGY 107
Cdd:cd13400    1 YGVPPRLLRAIAKVESGFNPNAINRNKNGSYDIGLMQINSIWLPELARYGITReelLNDPCTNIYVGAWILARNIKRYGN 80

                         90       100
                 ....*....|....*....|....*....
gi 499736863 108 TWEAVGAYNASQKHKRARYARKVYTALRK 136
Cdd:cd13400   81 TWKAVGAYNSGTPKKNDKYARKVYRIYRR 109
PRK15328 PRK15328
type III secretion system invasion protein IagB;
1-136 3.90e-39

type III secretion system invasion protein IagB;


Pssm-ID: 185228 [Multi-domain]  Cd Length: 160  Bit Score: 129.21  E-value: 3.90e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499736863   1 MKKVVVLFSLLFLFPAGQlhAFCFEEAGSIYNVSPRLLWAIARVESGFRPGALNRNADGSYDYGLMQINSSW---ARVVG 77
Cdd:PRK15328   1 MHYFFIIVIWLLSINTAW--ADCWLQAEKMFNIESELLYAIAQQESAMKPGAIGHNRDGSTDLGLMQINSFHmkrLKKMG 78

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 499736863  78 KELWSSLGDPCTNVKVGAWILSDCIRKHGYTWEAVGAYNASQKHKRA----RYARKVYTALRK 136
Cdd:PRK15328  79 ISEKQLLQDPCISVIVGASILSDMMKIYGYSWEAVGAYNAGTSPKRSdirkRYAKKIWENYRK 141
SLT pfam01464
Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found ...
 24-117 4.75e-23

Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found in phages, type II, type III and type IV secretion systems.


Pssm-ID: 396169 [Multi-domain]  Cd Length: 114  Bit Score: 86.59  E-value: 4.75e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499736863   24 FEEAGSIYNVSPRLLWAIARVESGFRPGALNRnadgSYDYGLMQINSSWARVVGKELWSS---LGDPCTNVKVGAWILSD 100
Cdd:pfam01464   1 IIKAAQKYGVDPSLLLAIAQQESGFNPKAVSK----SGAVGLMQIMPSTAKRLGLRVNPGvddLFDPEKNIKAGTKYLKE 76

                          90
                  ....*....|....*...
gi 499736863  101 CIRKHG-YTWEAVGAYNA 117
Cdd:pfam01464  77 LYKQYGgDLWLALAAYNA 94
LT-like cd00254
lytic transglycosylase(LT)-like domain; Members include the soluble and insoluble ...
 35-117 2.53e-19

lytic transglycosylase(LT)-like domain; Members include the soluble and insoluble membrane-bound LTs in bacteria and LTs in bacteriophage lambda. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381594 [Multi-domain]  Cd Length: 111  Bit Score: 77.25  E-value: 2.53e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499736863  35 PRLLWAIARVESGFRPGAlnRNADGSYdyGLMQINSSWARVVGKELWSSLGDPCTNVKVGAWILSDCIRKHGYTWE-AVG 113
Cdd:cd00254    1 PALVLAVIRVESGFNPRA--VSPAGAR--GLMQLMPGTARDLGRRGVDDLFDPEENIRAGARYLRELLDRFGGDLElALA 76


                 ....
gi 499736863 114 AYNA 117
Cdd:cd00254   77 AYNA 80
PRK13722 PRK13722
lytic transglycosylase; Provisional
 1-131 3.60e-17

lytic transglycosylase; Provisional


Pssm-ID: 184274 [Multi-domain]  Cd Length: 169  Bit Score: 73.19  E-value: 3.60e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499736863   1 MKKVVVLFSLLFLFPAgqLHAF-CFEEAGSIYNVSPRLLWAIARVESGFRPGALNRNADGSYDYGLMQINSS----WARV 75
Cdd:PRK13722   1 MKKWMLAICLMFINEI--CHATdCFDLAGRDYKIDPDLLRAISWKESRYRVNAIGINPVTGYGSGLMQVDSQhfneLARY 78

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 499736863  76 vGKELWSSLGDPCTNVKVGAWILSDCIRKHGYTWEAVGAYNAS------QKHKRARYARKVY 131
Cdd:PRK13722  79 -GIKPEHLTTDPCMNIYTGAYYLAIAFKKWGVSWEAVGAYNAGfrkterQNQRRLAYASEVY 139
MltE COG0741
Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin ...
 24-117 6.48e-16

Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin domain) [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440504 [Multi-domain]  Cd Length: 244  Bit Score: 71.18  E-value: 6.48e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499736863  24 FEEAGSIYNVSPRLLWAIARVESGFRPGALNR-NAdgsydYGLMQINSSWARVVGKEL-----WSSLGDPCTNVKVGAWI 97
Cdd:COG0741  107 IEEAAKKYGVDPALVLALIRQESAFNPNAVSPaGA-----RGLMQLMPATARRLGLKLglgpsPDDLFDPETNIRAGAAY 181

                         90       100
                 ....*....|....*....|.
gi 499736863  98 LSDCIRKHGYTWE-AVGAYNA 117
Cdd:COG0741  182 LRELLDRFDGDLVlALAAYNA 202
LT_VirB1-like cd16892
VirB1-like subfamily; This subfamily includes VirB1 protein, one of twelve proteins making up ...
 32-124 9.71e-14

VirB1-like subfamily; This subfamily includes VirB1 protein, one of twelve proteins making up type IV secretion systems (T4SS). T4SS are macromolecular assemblies generally composed of VirB1-11 and VirD4 proteins, and are used by bacteria to transport material across their membranes. VirB1 acts as a lytic transglycosylase (LT), and is important with respect to piercing the peptidoglycan layer in the periplasm. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc) as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL).


Pssm-ID: 381613 [Multi-domain]  Cd Length: 143  Bit Score: 63.33  E-value: 9.71e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499736863  32 NVSPRLLWAIARVESGFRPGALNRNADG-----------------------SYDYGLMQINSswarvvgkELWSSLG--- 85
Cdd:cd16892    8 GVHPETLAAIVQVESGGNPYAIGVNGGKlsrqpktkaeaiatarqliaaghNFDVGLGQINS--------RNLARLGltv 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 499736863  86 ----DPCTNVKVGAWILSDCIRKhgytweAVGAYNASQKHKRA 124
Cdd:cd16892   80 edvfDPCTNLKAGATILTECYAR------AKKTGGDGQAALRA 116
Slt70-like cd13401
70kDa soluble lytic transglycosylase (Slt70) and similar proteins; Catalytic domain of the ...
 24-117 5.96e-13

70kDa soluble lytic transglycosylase (Slt70) and similar proteins; Catalytic domain of the 70kda soluble lytic transglycosylase (LT)-like proteins, which also have an N-terminal U-shaped U-domain and a linker L-domain. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda.


Pssm-ID: 381604 [Multi-domain]  Cd Length: 152  Bit Score: 61.72  E-value: 5.96e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499736863  24 FEEAGSIYNVSPRLLWAIARVESGFRPGALNRnadgSYDYGLMQINSSWARVVGKEL------WSSLGDPCTNVKVGAWI 97
Cdd:cd13401   10 VERAAKKNGLDPALVYAIIRQESAFDPDAVSP----AGALGLMQLMPATAKDVAKKLglpyysPRDLFDPEYNIRLGSAY 85

                         90       100
                 ....*....|....*....|.
gi 499736863  98 LSDCIRKHGYTWE-AVGAYNA 117
Cdd:cd13401   86 LAELLDRFDGNPVlALAAYNA 106
LT_Slt70-like cd16896
uncharacterized lytic transglycosylase subfamily with similarity to Slt70; Uncharacterized ...
 31-117 1.20e-11

uncharacterized lytic transglycosylase subfamily with similarity to Slt70; Uncharacterized lytic transglycosylase (LT) with a conserved sequence pattern suggesting similarity to the Slt70, a 70kda soluble lytic transglycosylase which also has an N-terminal U-shaped U-domain and a linker L-domain. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381617 [Multi-domain]  Cd Length: 146  Bit Score: 58.29  E-value: 1.20e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499736863  31 YNVSPRLLWAIARVESGFRPGAL-NRNAdgsydYGLMQINSS---WARVVGKELWSS---LGDPCTNVKVGAWILSDCIR 103
Cdd:cd16896   15 YGVDPLLVAAVIKVESNFNPNAVsSKGA-----IGLMQIMPEtaeWIAEKLGLEDFSeddLYDPETNIRLGTWYLSYLLK 89

                         90
                 ....*....|....*
gi 499736863 104 KHGYTWE-AVGAYNA 117
Cdd:cd16896   90 EFDGNLVlALAAYNA 104
LYZ_C cd16897
C-type lysozyme; C-type lysozyme (chicken or conventional type; 1, 4-beta-N-acetylmuramidase). ...
 42-72 3.23e-09

C-type lysozyme; C-type lysozyme (chicken or conventional type; 1, 4-beta-N-acetylmuramidase). In humans, lysozyme is found in a wide variety of tissue types and body fluids. It has bacteriolytic properties through the hydolysis of beta-1,4, glyocosidic linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan, as well as between N-acetyl-D-glucosamine residues in chitodextrins. This family also includes digestive stomach lysozyme, which allow ruminants to digest bacteria in the foregut. The mammalian enzyme is related to lysozyme found hen egg-whites and related species.


Pssm-ID: 340383  Cd Length: 126  Bit Score: 51.50  E-value: 3.23e-09
                         10        20        30
                 ....*....|....*....|....*....|.
gi 499736863  42 ARVESGFRPGALNRNADGSYDYGLMQINSSW 72
Cdd:cd16897   32 AYYESGFNTRATNENPDGSTDYGIFQINSRY 62
GEWL cd01021
Goose egg-white lysozyme; Eukaryotic goose-type or G-type lysozyme (goose egg-white lysozyme; ...
 23-117 5.65e-09

Goose egg-white lysozyme; Eukaryotic goose-type or G-type lysozyme (goose egg-white lysozyme; GEWL) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc). Mammals have two lysozymes. This family corresponds to human and mouse lysozyme G-like protein 2.


Pssm-ID: 381601 [Multi-domain]  Cd Length: 174  Bit Score: 51.45  E-value: 5.65e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499736863  23 CFEEAGSIYNVSPRLLWAIARVESgfRPG-ALNRNA--DGSYDYGLMQINSSWARVVGKelWSSlgdpCTNVKVGAWILS 99
Cdd:cd01021   40 CIKQVGKKLCIDPALIAAIISRES--RAGaALDKNGwgDHGNGFGLMQVDKRYHPPKGA--WDS----EEHIEQATGILI 111

                         90       100
                 ....*....|....*....|....*...
gi 499736863 100 DCI----RKH-GYTWE-----AVGAYNA 117
Cdd:cd01021  112 DFIktvqRKHpSWSPEqqlkgGIAAYNA 139
PRK13864 PRK13864
type IV secretion system lytic transglycosylase VirB1; Provisional
 33-135 1.69e-07

type IV secretion system lytic transglycosylase VirB1; Provisional


Pssm-ID: 237534  Cd Length: 245  Bit Score: 48.32  E-value: 1.69e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499736863  33 VSPRLLWAIARVESGFRPGALNRNADG-----------------------SYDYGLMQINSSWARVVGKELWSSLgDPCT 89
Cdd:PRK13864  41 VAPSTLAAIAKVESRFDPLAVHDNTTGetlhwqnhaqatqsvrhrlearhSLDVGLMQINSKNFSVLGLTPDGAL-QPCT 119

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 499736863  90 NVKVGAWILsdcIRKH--GYTWE--------AVGAYNASQ-KHKRAR-YARKVYTALR 135
Cdd:PRK13864 120 SLSAAANLL---GSRYagGDTADekqlalrrAISAYNTGDfTRGFANgYVRKVETAAQ 174
LT_MltC_MltE cd16893
membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins; MltC and ...
 31-95 1.78e-07

membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins; MltC and MltE are periplasmic, outer membrane attached lytic transglycosylases (LTs), which cleave beta-1,4-glycosidic bonds joining N-acetylmuramic acid and N-acetylglucosamine in the cell wall peptidoglycan, yielding 1,6-anhydromuropeptides. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda


Pssm-ID: 381614 [Multi-domain]  Cd Length: 162  Bit Score: 47.17  E-value: 1.78e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 499736863  31 YNVSPRLLWAIARVESGFRPGALNR-NAdgsydYGLMQINSSWA------RVVGKELWSS---LGDPCTNVKVGA 95
Cdd:cd16893   10 YGVDPALILAIIETESSFNPYAVSHsPA-----YGLMQIVPSTAgrdvyrLLGGKGGLPSksyLFDPENNIDIGT 79
MLTF-like cd13403
membrane-bound lytic murein transglycosylase F (MLTF) and similar proteins; This subfamily ...
 24-129 4.14e-07

membrane-bound lytic murein transglycosylase F (MLTF) and similar proteins; This subfamily includes membrane-bound lytic murein transglycosylase F (MltF, murein lyase F) that degrades murein glycan strands. It is responsible for catalyzing the release of 1,6-anhydromuropeptides from peptidoglycan. Lytic transglycosylase catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc) as do goose-type lysozymes. However, in addition, it also makes a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381606 [Multi-domain]  Cd Length: 161  Bit Score: 46.37  E-value: 4.14e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499736863  24 FEEAGSIYNVSPRLLWAIARVESGFRPGAlnRNADGSydYGLMQINSSWARVVGkelWSSLGDPCTNVKVGAWILSDcIR 103
Cdd:cd13403    1 FKKYAEKYGFDWRLLAAQAYQESRFNPNA--RSPAGA--RGLMQLMPSTARELG---VNDRLDPEQNIHAGAKYLRY-LR 72

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 499736863 104 KHGY--------TWEAVGAYNASQKH-KRAR-YARK 129
Cdd:cd13403   73 DRFPpdidepdrLKFALAAYNAGPGHvRDARrLAKK 108
Lyz-like cd00442
lysozyme-like domains; This family contains several members, including soluble lytic ...
 40-97 6.10e-07

lysozyme-like domains; This family contains several members, including soluble lytic transglycosylases (SLT), goose egg-white lysozymes (GEWL), hen egg-white lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, chitosanases, and pesticin. Typical members are involved in the hydrolysis of beta-1,4- linked polysaccharides.


Pssm-ID: 381596 [Multi-domain]  Cd Length: 59  Bit Score: 43.94  E-value: 6.10e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 499736863  40 AIARVESGFRPGAlnRNADGSYDYGLMQINSSWARVVGKELWSSLGDPCTNVKVGAWI 97
Cdd:cd00442    4 AIIGQESGGNKPA--NAGSGSGAAGLFQFMPGTWKAYGKNSSSDLNDPEASIEAAAKY 59
LYZ1 smart00263
Alpha-lactalbumin / lysozyme C;
41-72 9.81e-07

Alpha-lactalbumin / lysozyme C;


Pssm-ID: 197612  Cd Length: 127  Bit Score: 44.59  E-value: 9.81e-07
                           10        20        30
                   ....*....|....*....|....*....|..
gi 499736863    41 IARVESGFRPGALNRNADGSYDYGLMQINSSW 72
Cdd:smart00263  31 LAFHESGYNTQATNYNNGGSTDYGIFQINSKY 62
SLT_3 pfam18896
Lysozyme like domain; This entry represents a lysozyme like domain found in candidate phyla ...
 40-110 1.03e-06

Lysozyme like domain; This entry represents a lysozyme like domain found in candidate phyla radiation bacteria. The domain contains several conserved cysteine and histidine residues suggesting that it may bind to zinc.


Pssm-ID: 436815 [Multi-domain]  Cd Length: 89  Bit Score: 43.93  E-value: 1.03e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 499736863   40 AIARVESGFRPGALN--RNADGSYDYGLMQINSSWARVVGkELWSSLGDPCTNVKVgAWILSDcirkHGYTWE 110
Cdd:pfam18896  19 AVAMAESGGDPSAVGdlANTKGSPSRGLWQINSLAHPEVT-GPDACAYDPQCNAKA-AYAISS----GGTNWS 85
emtA PRK15470
membrane-bound lytic murein transglycosylase EmtA;
25-106 1.08e-06

membrane-bound lytic murein transglycosylase EmtA;


Pssm-ID: 185367 [Multi-domain]  Cd Length: 203  Bit Score: 45.73  E-value: 1.08e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499736863  25 EEAGSIYNVSPRLLWAIARVESGFRPGALNRnadgSYDYGLMQINSSWA-RVVGKEL-W------SSLGDPCTNVKVGAW 96
Cdd:PRK15470  44 QKAGAAWGVDPQLITAIIAIESGGNPNAVSK----SNAIGLMQLKASTSgRDVYRRMgWsgepttSELKNPERNISMGAA 119

                         90
                 ....*....|
gi 499736863  97 ILSdcIRKHG 106
Cdd:PRK15470 120 YLN--ILETG 127
LYZ_C_invert cd16899
C-type invertebrate lysozyme; C-type lysozyme proteins of invertebrates, including digestive ...
 41-72 2.31e-06

C-type invertebrate lysozyme; C-type lysozyme proteins of invertebrates, including digestive lysozymes 1 and 2 from Musca domestica, which aid in the use of bacteria as a food source. These lysozymes have high expression in the gut and optimal lytic activity at a lower pH. Other lysozymes in this subfamily have immunological roles. e.g. Anopheles gambiae has eight lysozymes, most of which seem to have immunological roles, those some may function as digestive enzymes in larvae. C-type lysozyme (chicken or conventional type; 1, 4-beta-N-acetylmuramidase) has bacteriolytic properties through the hydolysis of beta-1,4, glyocosidic linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan, as well as between N-acetyl-D-glucosamine residues in chitodextrins.


Pssm-ID: 381618 [Multi-domain]  Cd Length: 121  Bit Score: 43.75  E-value: 2.31e-06
                         10        20        30
                 ....*....|....*....|....*....|...
gi 499736863  41 IARVESGFRPGALNR-NADGSYDYGLMQINSSW 72
Cdd:cd16899   28 LAEHESSFNTTAVGGpNSDGSGDYGLFQINDKY 60
Slt35-like cd13399
Slt35-like lytic transglycosylase; Lytic transglycosylase similar to Escherichia coli lytic ...
 31-136 2.63e-06

Slt35-like lytic transglycosylase; Lytic transglycosylase similar to Escherichia coli lytic transglycosylase Slt35 and Pseudomonas aeruginosa Sltb1. Lytic transglycosylase (LT) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc) as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this this family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL).


Pssm-ID: 381602 [Multi-domain]  Cd Length: 108  Bit Score: 43.07  E-value: 2.63e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499736863  31 YNVSPRLLWAIARVESGFrpgalNRNADGSYD--YGLMQ-INSSWARVV------GKELWSSLGDP--------CTNVKV 93
Cdd:cd13399    1 YGVPPGILAAILGVESGF-----GPNAGGSPAgaQGIAQfMPSTWKAYGvdgngdGKADPFNPEDAiasaanylCRHGWD 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 499736863  94 GAWILSDCIRKhgytweAVGAYNASQKHkrarYARKVYTALRK 136
Cdd:cd13399   76 LNAFLGEDNFL------ALAAYNAGPGA----YANAVLELAAT 108
MltF COG4623
Membrane-bound lytic murein transglycosylase MltF [Cell wall/membrane/envelope biogenesis, ...
 24-125 3.89e-06

Membrane-bound lytic murein transglycosylase MltF [Cell wall/membrane/envelope biogenesis, Signal transduction mechanisms];


Pssm-ID: 443662 [Multi-domain]  Cd Length: 421  Bit Score: 44.67  E-value: 3.89e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499736863  24 FEEAGSIYNVSPRLLWAIARVESGFRPGALNR-NAdgsydYGLMQINSSWARVVG-KELWsslgDPCTNVKVGAW----- 96
Cdd:COG4623  268 FEKYAEEYGLDWRLLAALAYQESHWNPRARSPtGA-----RGLMQLMPATAKELGvDDRL----DPEQSIRAGAKylrwl 338

                         90       100       110
                 ....*....|....*....|....*....|..
gi 499736863  97 --ILSDCIRKHGYTWEAVGAYNASQKH-KRAR 125
Cdd:COG4623  339 ydRFPEAIDEPDRWWFALAAYNAGPGHvQDAR 370
PRK13888 PRK13888
conjugal transfer protein TrbN; Provisional
 31-74 1.34e-05

conjugal transfer protein TrbN; Provisional


Pssm-ID: 237545  Cd Length: 206  Bit Score: 42.89  E-value: 1.34e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 499736863  31 YNVSPRLLWAIARVESGfRPGALNRNADGSYDYGLMQINSSWAR 74
Cdd:PRK13888  25 YEVPANIVLAVAEKEGG-KPGQWVRNTNGTHDVGPMQFNTAYLG 67
Lys pfam00062
C-type lysozyme/alpha-lactalbumin family; Alpha-lactalbumin is the regulatory subunit of ...
 39-72 2.21e-05

C-type lysozyme/alpha-lactalbumin family; Alpha-lactalbumin is the regulatory subunit of lactose synthase, changing the substrate specificity of galactosyltransferase from N-acetylglucosamine to glucose. C-type lysozymes are secreted bacteriolytic enzymes that cleave the peptidoglycan of bacterial cell walls. Structure is a multi-domain, mixed alpha and beta fold, containing four conserved disulfide bonds.


Pssm-ID: 395016  Cd Length: 123  Bit Score: 41.25  E-value: 2.21e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 499736863   39 WA-IARVESGFRPGALNRNaDGSYDYGLMQINSSW 72
Cdd:pfam00062  28 WVcLAFHESGYDTQAIVYN-NGSTDYGIFQINDKY 61
LYZ cd00119
C-type lysozyme and alpha-lactalbumin; C-type lysozyme (chicken or conventional type, 1, ...
 45-70 1.48e-03

C-type lysozyme and alpha-lactalbumin; C-type lysozyme (chicken or conventional type, 1,4-beta-N-acetylmuramidase) and alpha-lactalbumin (lactose synthase B protein, LA). They have a close evolutionary relationship and similar tertiary structure, however, functionally they are quite different. Lysozymes have primarily bacteriolytic function; hydrolysis of peptidoglycans of prokaryotic cell walls and transglycosylation. LA is a calcium-binding metalloprotein that is expressed exclusively in the mammary gland during lactation. LA is the regulatory subunit of the enzyme lactose synthase. The association of LA with the catalytic component of lactose synthase, galactosyltransferase, alters the acceptor substrate specificity of this glycosyltransferase, facilitating biosynthesis of lactose. Some lysozymes have evolved into digestive enzymes, both in mammals and invertebrates.


Pssm-ID: 340357  Cd Length: 122  Bit Score: 36.01  E-value: 1.48e-03
                         10        20
                 ....*....|....*....|....*.
gi 499736863  45 ESGFRPGALNRNADGSYDYGLMQINS 70
Cdd:cd00119   33 ESGYDTQATNENNNGSTDYGLFQINS 58
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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