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Conserved domains on  [gi|499846621|ref|WP_011527355|]
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transglycosylase SLT domain-containing protein [Lawsonia intracellularis]

Protein Classification

lysozyme family protein( domain architecture ID 63)

lysozyme family protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MltF super family cl34791
Membrane-bound lytic murein transglycosylase MltF [Cell wall/membrane/envelope biogenesis, ...
 26-188 1.30e-44

Membrane-bound lytic murein transglycosylase MltF [Cell wall/membrane/envelope biogenesis, Signal transduction mechanisms];


The actual alignment was detected with superfamily member COG4623:

Pssm-ID: 443662 [Multi-domain]  Cd Length: 421  Bit Score: 153.29  E-value: 1.30e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499846621  26 AQRHRNVLIRVAREVwGMDAPvaLFAAQIHTESLWHENAVSPVGAQGLAQFMPETAAWLptvapetGEPLPFNPAWSLRA 105
Cdd:COG4623  261 LPPYDPLFEKYAEEY-GLDWR--LLAALAYQESHWNPRARSPTGARGLMQLMPATAKEL-------GVDDRLDPEQSIRA 330

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499846621 106 LVTYDLWLWERV-DAIYQCDQMAFMLSAYNGGLGWVQKDKRMAKDNGLDPNrYWDCVERINAGRRKSAF---QENRKYPK 181
Cdd:COG4623  331 GAKYLRWLYDRFpEAIDEPDRWWFALAAYNAGPGHVQDARRLAKKQGLDPD-RWFDVEKSQPKYYDTGYargRETVNYVP 409


                 ....*..
gi 499846621 182 VILHTYQ 188
Cdd:COG4623  410 NIRAYYD 416
 
Name Accession Description Interval E-value
MltF COG4623
Membrane-bound lytic murein transglycosylase MltF [Cell wall/membrane/envelope biogenesis, ...
 26-188 1.30e-44

Membrane-bound lytic murein transglycosylase MltF [Cell wall/membrane/envelope biogenesis, Signal transduction mechanisms];


Pssm-ID: 443662 [Multi-domain]  Cd Length: 421  Bit Score: 153.29  E-value: 1.30e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499846621  26 AQRHRNVLIRVAREVwGMDAPvaLFAAQIHTESLWHENAVSPVGAQGLAQFMPETAAWLptvapetGEPLPFNPAWSLRA 105
Cdd:COG4623  261 LPPYDPLFEKYAEEY-GLDWR--LLAALAYQESHWNPRARSPTGARGLMQLMPATAKEL-------GVDDRLDPEQSIRA 330

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499846621 106 LVTYDLWLWERV-DAIYQCDQMAFMLSAYNGGLGWVQKDKRMAKDNGLDPNrYWDCVERINAGRRKSAF---QENRKYPK 181
Cdd:COG4623  331 GAKYLRWLYDRFpEAIDEPDRWWFALAAYNAGPGHVQDARRLAKKQGLDPD-RWFDVEKSQPKYYDTGYargRETVNYVP 409


                 ....*..
gi 499846621 182 VILHTYQ 188
Cdd:COG4623  410 NIRAYYD 416
MLTF-like cd13403
membrane-bound lytic murein transglycosylase F (MLTF) and similar proteins; This subfamily ...
 49-164 6.87e-22

membrane-bound lytic murein transglycosylase F (MLTF) and similar proteins; This subfamily includes membrane-bound lytic murein transglycosylase F (MltF, murein lyase F) that degrades murein glycan strands. It is responsible for catalyzing the release of 1,6-anhydromuropeptides from peptidoglycan. Lytic transglycosylase catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc) as do goose-type lysozymes. However, in addition, it also makes a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381606 [Multi-domain]  Cd Length: 161  Bit Score: 87.21  E-value: 6.87e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499846621  49 LFAAQIHTESLWHENAVSPVGAQGLAQFMPETAAwlptvapETGEPLPFNPAWSLRALVTYDLWLWERVDAIY-QCDQMA 127
Cdd:cd13403   14 LLAAQAYQESRFNPNARSPAGARGLMQLMPSTAR-------ELGVNDRLDPEQNIHAGAKYLRYLRDRFPPDIdEPDRLK 86

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 499846621 128 FMLSAYNGGLGWVQKDKRMAKDNGLDPNRYWDCVERI 164
Cdd:cd13403   87 FALAAYNAGPGHVRDARRLAKKYGLNPNVWFDNVEVL 123
SLT pfam01464
Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found ...
 46-149 7.41e-14

Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found in phages, type II, type III and type IV secretion systems.


Pssm-ID: 396169 [Multi-domain]  Cd Length: 114  Bit Score: 65.02  E-value: 7.41e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499846621   46 PVALFAAQIHTESLWHENAVSPVGAQGLAQFMPETAAWL-PTVAPETGEplPFNPAWSLRALVTYdlwLWERVDaiyQCD 124
Cdd:pfam01464  11 DPSLLLAIAQQESGFNPKAVSKSGAVGLMQIMPSTAKRLgLRVNPGVDD--LFDPEKNIKAGTKY---LKELYK---QYG 82

                          90       100
                  ....*....|....*....|....*.
gi 499846621  125 Q-MAFMLSAYNGGLGWVQKDKRMAKD 149
Cdd:pfam01464  83 GdLWLALAAYNAGPGRVRKWIKNAGA 108
PRK10859 PRK10859
membrane-bound lytic murein transglycosylase MltF;
49-159 1.95e-08

membrane-bound lytic murein transglycosylase MltF;


Pssm-ID: 236778 [Multi-domain]  Cd Length: 482  Bit Score: 53.34  E-value: 1.95e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499846621  49 LFAAQIHTESLWHENAVSPVGAQGLAQFMPETAAWLpTVAPETgeplpfNPAWSLRALVTYDLWLWERV-DAIYQCDQMA 127
Cdd:PRK10859 305 LLAAIAYQESHWNPQATSPTGVRGLMMLTRNTAQSM-GVTDRL------DPEQSIRGGARYLQDLMERLpESIPEPERIW 377

                         90       100       110
                 ....*....|....*....|....*....|..
gi 499846621 128 FMLSAYNGGLGWVQKDKRMAKDNGLDPNRYWD 159
Cdd:PRK10859 378 FALAAYNIGYGHMLDARRLTKKQGGNPDSWAD 409
 
Name Accession Description Interval E-value
MltF COG4623
Membrane-bound lytic murein transglycosylase MltF [Cell wall/membrane/envelope biogenesis, ...
 26-188 1.30e-44

Membrane-bound lytic murein transglycosylase MltF [Cell wall/membrane/envelope biogenesis, Signal transduction mechanisms];


Pssm-ID: 443662 [Multi-domain]  Cd Length: 421  Bit Score: 153.29  E-value: 1.30e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499846621  26 AQRHRNVLIRVAREVwGMDAPvaLFAAQIHTESLWHENAVSPVGAQGLAQFMPETAAWLptvapetGEPLPFNPAWSLRA 105
Cdd:COG4623  261 LPPYDPLFEKYAEEY-GLDWR--LLAALAYQESHWNPRARSPTGARGLMQLMPATAKEL-------GVDDRLDPEQSIRA 330

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499846621 106 LVTYDLWLWERV-DAIYQCDQMAFMLSAYNGGLGWVQKDKRMAKDNGLDPNrYWDCVERINAGRRKSAF---QENRKYPK 181
Cdd:COG4623  331 GAKYLRWLYDRFpEAIDEPDRWWFALAAYNAGPGHVQDARRLAKKQGLDPD-RWFDVEKSQPKYYDTGYargRETVNYVP 409


                 ....*..
gi 499846621 182 VILHTYQ 188
Cdd:COG4623  410 NIRAYYD 416
MLTF-like cd13403
membrane-bound lytic murein transglycosylase F (MLTF) and similar proteins; This subfamily ...
 49-164 6.87e-22

membrane-bound lytic murein transglycosylase F (MLTF) and similar proteins; This subfamily includes membrane-bound lytic murein transglycosylase F (MltF, murein lyase F) that degrades murein glycan strands. It is responsible for catalyzing the release of 1,6-anhydromuropeptides from peptidoglycan. Lytic transglycosylase catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc) as do goose-type lysozymes. However, in addition, it also makes a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381606 [Multi-domain]  Cd Length: 161  Bit Score: 87.21  E-value: 6.87e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499846621  49 LFAAQIHTESLWHENAVSPVGAQGLAQFMPETAAwlptvapETGEPLPFNPAWSLRALVTYDLWLWERVDAIY-QCDQMA 127
Cdd:cd13403   14 LLAAQAYQESRFNPNARSPAGARGLMQLMPSTAR-------ELGVNDRLDPEQNIHAGAKYLRYLRDRFPPDIdEPDRLK 86

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 499846621 128 FMLSAYNGGLGWVQKDKRMAKDNGLDPNRYWDCVERI 164
Cdd:cd13403   87 FALAAYNAGPGHVRDARRLAKKYGLNPNVWFDNVEVL 123
Slt35-like cd13399
Slt35-like lytic transglycosylase; Lytic transglycosylase similar to Escherichia coli lytic ...
 46-138 2.32e-20

Slt35-like lytic transglycosylase; Lytic transglycosylase similar to Escherichia coli lytic transglycosylase Slt35 and Pseudomonas aeruginosa Sltb1. Lytic transglycosylase (LT) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc) as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this this family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL).


Pssm-ID: 381602 [Multi-domain]  Cd Length: 108  Bit Score: 81.97  E-value: 2.32e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499846621  46 PVALFAAQIHTESLWHENAV-SPVGAQGLAQFMPETAAWLPTVAPETGEPLPFNPAWSLRALVTYDLWLWERVDAIYqCD 124
Cdd:cd13399    4 PPGILAAILGVESGFGPNAGgSPAGAQGIAQFMPSTWKAYGVDGNGDGKADPFNPEDAIASAANYLCRHGWDLNAFL-GE 82

                         90
                 ....*....|....
gi 499846621 125 QMAFMLSAYNGGLG 138
Cdd:cd13399   83 DNFLALAAYNAGPG 96
MltE COG0741
Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin ...
 36-188 2.90e-20

Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin domain) [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440504 [Multi-domain]  Cd Length: 244  Bit Score: 85.05  E-value: 2.90e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499846621  36 VAREVWGMDAPVALFAAQIHTESLWHENAVSPVGAQGLAQFMPETAAWlptVAPETGEP----LPFNPAWSLRALVTYDL 111
Cdd:COG0741  107 IEEAAKKYGVDPALVLALIRQESAFNPNAVSPAGARGLMQLMPATARR---LGLKLGLGpspdDLFDPETNIRAGAAYLR 183

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 499846621 112 WLWERVDaiyqcDQMAFMLSAYNGGLGWVqkDKRMAKDNGLDPnrywdcvERINagrrksaFQENRKYPKVILHTYQ 188
Cdd:COG0741  184 ELLDRFD-----GDLVLALAAYNAGPGRV--RRWLRRNGDRDG-------EIIP-------YAETRNYVKKVLANYA 239
LT_Slt70-like cd16896
uncharacterized lytic transglycosylase subfamily with similarity to Slt70; Uncharacterized ...
 22-189 1.35e-16

uncharacterized lytic transglycosylase subfamily with similarity to Slt70; Uncharacterized lytic transglycosylase (LT) with a conserved sequence pattern suggesting similarity to the Slt70, a 70kda soluble lytic transglycosylase which also has an N-terminal U-shaped U-domain and a linker L-domain. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381617 [Multi-domain]  Cd Length: 146  Bit Score: 72.93  E-value: 1.35e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499846621  22 IPYAAQrhrnvlIRVAREVWGMDApvALFAAQIHTESLWHENAVSPVGAQGLAQFMPETAAWlptVAPETGEPLP----- 96
Cdd:cd16896    2 LKYREY------IEKYAKEYGVDP--LLVAAVIKVESNFNPNAVSSKGAIGLMQIMPETAEW---IAEKLGLEDFseddl 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499846621  97 FNPAWSLRALVTYDLWLWERVDaiyqcDQMAFMLSAYNGGLGWVqkdKRMAKDNGLDPNryWDCVERINagrrksaFQEN 176
Cdd:cd16896   71 YDPETNIRLGTWYLSYLLKEFD-----GNLVLALAAYNAGPGNV---DKWLKDGGWSGD--GKTLDQIP-------FPET 133

                        170
                 ....*....|...
gi 499846621 177 RKYPKVILHTYQK 189
Cdd:cd16896  134 RHYVKKVLKNYKI 146
LT-like cd00254
lytic transglycosylase(LT)-like domain; Members include the soluble and insoluble ...
 48-188 7.38e-16

lytic transglycosylase(LT)-like domain; Members include the soluble and insoluble membrane-bound LTs in bacteria and LTs in bacteriophage lambda. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381594 [Multi-domain]  Cd Length: 111  Bit Score: 70.32  E-value: 7.38e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499846621  48 ALFAAQIHTESLWHENAVSPVGAQGLAQFMPETAAWLPTVAPEtgepLPFNPAWSLRALVTYDLWLWERVDaiyqcDQMA 127
Cdd:cd00254    2 ALVLAVIRVESGFNPRAVSPAGARGLMQLMPGTARDLGRRGVD----DLFDPEENIRAGARYLRELLDRFG-----GDLE 72

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 499846621 128 FMLSAYNGGLGWVQKdkrmakdngldpnrywdcveriNAGRRKSAFQENRKYPKVILHTYQ 188
Cdd:cd00254   73 LALAAYNAGPGAVDR----------------------WGGGEVPPYKETRNYVQRVLAYYQ 111
SLT pfam01464
Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found ...
 46-149 7.41e-14

Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found in phages, type II, type III and type IV secretion systems.


Pssm-ID: 396169 [Multi-domain]  Cd Length: 114  Bit Score: 65.02  E-value: 7.41e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499846621   46 PVALFAAQIHTESLWHENAVSPVGAQGLAQFMPETAAWL-PTVAPETGEplPFNPAWSLRALVTYdlwLWERVDaiyQCD 124
Cdd:pfam01464  11 DPSLLLAIAQQESGFNPKAVSKSGAVGLMQIMPSTAKRLgLRVNPGVDD--LFDPEKNIKAGTKY---LKELYK---QYG 82

                          90       100
                  ....*....|....*....|....*.
gi 499846621  125 Q-MAFMLSAYNGGLGWVQKDKRMAKD 149
Cdd:pfam01464  83 GdLWLALAAYNAGPGRVRKWIKNAGA 108
Slt70-like cd13401
70kDa soluble lytic transglycosylase (Slt70) and similar proteins; Catalytic domain of the ...
 46-188 6.40e-13

70kDa soluble lytic transglycosylase (Slt70) and similar proteins; Catalytic domain of the 70kda soluble lytic transglycosylase (LT)-like proteins, which also have an N-terminal U-shaped U-domain and a linker L-domain. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda.


Pssm-ID: 381604 [Multi-domain]  Cd Length: 152  Bit Score: 63.65  E-value: 6.40e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499846621  46 PVALFAAQIHTESLWHENAVSPVGAQGLAQFMPETAAWlptVAPETGEPLP-----FNPAWSLRaLVTYDL-WLWERVDa 119
Cdd:cd13401   20 DPALVYAIIRQESAFDPDAVSPAGALGLMQLMPATAKD---VAKKLGLPYYsprdlFDPEYNIR-LGSAYLaELLDRFD- 94

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 499846621 120 iyqcDQMAFMLSAYNGGLGWVqkdKRMAKDNGLDPNRYWdcVERInagrrksAFQENRKYPKVILHTYQ 188
Cdd:cd13401   95 ----GNPVLALAAYNAGPGRV---RRWLKRRGDLDPDLW--IETI-------PFSETRNYVKRVLENYV 147
PRK10859 PRK10859
membrane-bound lytic murein transglycosylase MltF;
49-159 1.95e-08

membrane-bound lytic murein transglycosylase MltF;


Pssm-ID: 236778 [Multi-domain]  Cd Length: 482  Bit Score: 53.34  E-value: 1.95e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499846621  49 LFAAQIHTESLWHENAVSPVGAQGLAQFMPETAAWLpTVAPETgeplpfNPAWSLRALVTYDLWLWERV-DAIYQCDQMA 127
Cdd:PRK10859 305 LLAAIAYQESHWNPQATSPTGVRGLMMLTRNTAQSM-GVTDRL------DPEQSIRGGARYLQDLMERLpESIPEPERIW 377

                         90       100       110
                 ....*....|....*....|....*....|..
gi 499846621 128 FMLSAYNGGLGWVQKDKRMAKDNGLDPNRYWD 159
Cdd:PRK10859 378 FALAAYNIGYGHMLDARRLTKKQGGNPDSWAD 409
mltC PRK11671
membrane-bound lytic murein transglycosylase MltC;
33-191 7.18e-07

membrane-bound lytic murein transglycosylase MltC;


Pssm-ID: 183271 [Multi-domain]  Cd Length: 359  Bit Score: 48.51  E-value: 7.18e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499846621  33 LIRVAREVWGMDAPVALfaAQIHTESLWHENAVSPVGAQGLAQFMPETAA---------WlptvapetGEP---LPFNPA 100
Cdd:PRK11671 195 MVRKASRKYGVDESLIL--AIMQTESSFNPYAVSRSDALGLMQVVQHTAGkdvfrmkgkS--------GQPsrsYLFDPA 264

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499846621 101 WSLRALVTYdLWLWERV--DAIYQCDQMAF-MLSAYNGGLGWV------QKDKRMAKDNGLDPnrywDCVERINAGRRKS 171
Cdd:PRK11671 265 NNIDTGTAY-LAILQNVylGGITNPTSRRYaVITAYNGGAGSVlrvfsnDKIQAANIINTMSP----GDVYQTLTTRHPS 339

                        170       180
                 ....*....|....*....|.
gi 499846621 172 AfqENRKY-PKVilHTYQKKY 191
Cdd:PRK11671 340 A--ESRRYlYKV--NTAQKSY 356
LT_MltC_MltE cd16893
membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins; MltC and ...
 34-82 7.04e-05

membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins; MltC and MltE are periplasmic, outer membrane attached lytic transglycosylases (LTs), which cleave beta-1,4-glycosidic bonds joining N-acetylmuramic acid and N-acetylglucosamine in the cell wall peptidoglycan, yielding 1,6-anhydromuropeptides. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda


Pssm-ID: 381614 [Multi-domain]  Cd Length: 162  Bit Score: 41.39  E-value: 7.04e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 499846621  34 IRVAREVWGMDApvALFAAQIHTESLWHENAVSPVGAQGLAQFMPETAA 82
Cdd:cd16893    3 VEKYAKKYGVDP--ALILAIIETESSFNPYAVSHSPAYGLMQIVPSTAG 49
MltD-like cd16894
Membrane-bound lytic murein transglycosylase D and similar proteins; Lytic transglycosylases ...
 57-81 1.83e-04

Membrane-bound lytic murein transglycosylase D and similar proteins; Lytic transglycosylases (LT) catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc). Membrane-bound lytic murein transglycosylase D protein (MltD) family members may have one or more small LysM domains, which may contribute to peptidoglycan binding. Unlike the similar "goose-type" lysozymes, LTs also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL).


Pssm-ID: 381615 [Multi-domain]  Cd Length: 129  Bit Score: 39.81  E-value: 1.83e-04
                         10        20
                 ....*....|....*....|....*
gi 499846621  57 ESLWHENAVSPVGAQGLAQFMPETA 81
Cdd:cd16894   17 ESGFNPDAVSSAGAAGLWQFMPATA 41
PRK11619 PRK11619
lytic murein transglycosylase; Provisional
 57-81 4.33e-04

lytic murein transglycosylase; Provisional


Pssm-ID: 183236 [Multi-domain]  Cd Length: 644  Bit Score: 40.43  E-value: 4.33e-04
                         10        20
                 ....*....|....*....|....*
gi 499846621  57 ESLWHENAVSPVGAQGLAQFMPETA 81
Cdd:PRK11619 504 ESAWNPKARSPVGASGLMQIMPGTA 528
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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