NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|499882782|ref|WP_011563516|]
View 

TIGR03667 family PPOX class F420-dependent oxidoreductase [Rubrobacter xylanophilus]

Protein Classification

pyridoxamine 5'-phosphate oxidase family protein; nitroreductase family deazaflavin-dependent oxidoreductase( domain architecture ID 10022756)

pyridoxamine 5'-phosphate oxidase family protein may utilize either FMN or F420 as a cofactor| nitroreductase family deazaflavin-dependent oxidoreductase similar to Mycobacterium tuberculosis deazaflavin-dependent nitroreductase and F420H(2)-dependent quinone reductase

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Rv3369 TIGR03667
PPOX class probable F420-dependent enzyme, Rv3369 family; A Genome Properties metabolic ...
 2-131 3.72e-76

PPOX class probable F420-dependent enzyme, Rv3369 family; A Genome Properties metabolic reconstruction for F420 biosynthesis shows that slightly over 10 percent of all prokaryotes with fully sequenced genomes, including about two thirds of the Actinomycetales, make F420. A variant of the Partial Phylogenetic Profiling algorithm, SIMBAL, shows that this protein likely binds F420 in a cleft similar to that in which the homologous enzyme pyridoxamine phosphate oxidase (PPOX) binds FMN. [Unknown function, Enzymes of unknown specificity]


:

Pssm-ID: 132706  Cd Length: 130  Bit Score: 221.96  E-value: 3.72e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499882782    2 AVVEPWVERRLREEKILWLTTVRADGQPQPVPVWFLWGTEGFLIYSRPNAQKLRNIRSNPRVGLNLNCDERGGSVVRAEG 81
Cdd:TIGR03667   1 TEFTAKVARRLREESIVWLTTVRRSGQPQPVPVWFLWDGTEFLIYSRPQAAKLRNIRRNPRVSLHLNSDGRGGDVVVFTG 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 499882782   82 TAEIVEDAAPASEIPEYVQKYREDMRRLGYEPAGFALDYAVAVRVTPRRW 131
Cdd:TIGR03667  81 TAEVVADAPPAREIPAYLAKYREDAARIGMTPERFAADYSVPLRVTPERL 130
 
Name Accession Description Interval E-value
Rv3369 TIGR03667
PPOX class probable F420-dependent enzyme, Rv3369 family; A Genome Properties metabolic ...
 2-131 3.72e-76

PPOX class probable F420-dependent enzyme, Rv3369 family; A Genome Properties metabolic reconstruction for F420 biosynthesis shows that slightly over 10 percent of all prokaryotes with fully sequenced genomes, including about two thirds of the Actinomycetales, make F420. A variant of the Partial Phylogenetic Profiling algorithm, SIMBAL, shows that this protein likely binds F420 in a cleft similar to that in which the homologous enzyme pyridoxamine phosphate oxidase (PPOX) binds FMN. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 132706  Cd Length: 130  Bit Score: 221.96  E-value: 3.72e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499882782    2 AVVEPWVERRLREEKILWLTTVRADGQPQPVPVWFLWGTEGFLIYSRPNAQKLRNIRSNPRVGLNLNCDERGGSVVRAEG 81
Cdd:TIGR03667   1 TEFTAKVARRLREESIVWLTTVRRSGQPQPVPVWFLWDGTEFLIYSRPQAAKLRNIRRNPRVSLHLNSDGRGGDVVVFTG 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 499882782   82 TAEIVEDAAPASEIPEYVQKYREDMRRLGYEPAGFALDYAVAVRVTPRRW 131
Cdd:TIGR03667  81 TAEVVADAPPAREIPAYLAKYREDAARIGMTPERFAADYSVPLRVTPERL 130
YzzA COG3871
General stress protein 26 (function unknown) [Function unknown];
2-134 9.07e-24

General stress protein 26 (function unknown) [Function unknown];


Pssm-ID: 443080 [Multi-domain]  Cd Length: 132  Bit Score: 88.84  E-value: 9.07e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499882782   2 AVVEPWVERRLREEKILWLTTVRADGQPQPVPVWFLWGTEGFLIY--SRPNAQKLRNIRSNPRVGLNLnCDERGGSVVRA 79
Cdd:COG3871    5 EELEEKLWELLEDIRTAMLATVDADGRPHSRPMWFQVDVDDGTLWffTSRDSAKVRNIRRDPRVSLSF-ADPGDDRYVSV 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 499882782  80 EGTAEIVEDAAPASEIPE-YVQKYREDmrrlGYEPAGFALdyavaVRVTPRRWQSW 134
Cdd:COG3871   84 EGTAEIVDDRAKIDELWNpLAEAWFPD----GPDDPDLVL-----LRVTPERAEYW 130
Putative_PNPOx pfam01243
Pyridoxamine 5'-phosphate oxidase; Family of domains with putative PNPOx function. Family ...
 4-90 9.11e-20

Pyridoxamine 5'-phosphate oxidase; Family of domains with putative PNPOx function. Family members were predicted to encode pyridoxamine 5'-phosphate oxidase, based on sequence similarity. However, there is no experimental data to validate the predicted activity and purified proteins, such as Swiss:Q06199 and its paralogs, do not possess this activity, nor do they bind to flavin mononucleotide (FMN). To date, the only time functional oxidase activity has been experimentally demonstrated is when the sequences contain both pfam01243 and pfam10590. Moreover, some of the family members that contain both domains have been shown to be involved in phenazine biosynthesis. While some molecular function has been experimentally validated for the proteins containing both domains, the role performed by each domain on its own is unknown.


Pssm-ID: 426149 [Multi-domain]  Cd Length: 88  Bit Score: 77.29  E-value: 9.11e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499882782    4 VEPWVERRLREEKILWLTTVRADGQPQPVPVWFLWG--TEGFLIYSRPNAQKLRNIRSNPRVGLNLnCDERGGSVVRAEG 81
Cdd:pfam01243   1 LTEEIREFLAEPNAVVLATVDKDGRPNVRPVGLKYGfdTVGILFATNTDSRKARNLEENPRVALLF-GDPELRRGVRIEG 79


                  ....*....
gi 499882782   82 TAEIVEDAA 90
Cdd:pfam01243  80 TAEIVTDGE 88
PLN03049 PLN03049
pyridoxine (pyridoxamine) 5'-phosphate oxidase; Provisional
 8-89 4.68e-03

pyridoxine (pyridoxamine) 5'-phosphate oxidase; Provisional


Pssm-ID: 215550 [Multi-domain]  Cd Length: 462  Bit Score: 35.60  E-value: 4.68e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499882782   8 VERRLREEKILWLTTVRADGQPQPVPVwFLWGTE--GFLIYSRPNAQKLRNIRSNPRVGLNLNCDERGGSvVRAEGTAEI 85
Cdd:PLN03049 282 VAAGLREPNAMTLATAGEDGRPSARIV-LLKGVDkrGFVWYTNYDSRKAHELSANPKASLVFYWDGLHRQ-VRVEGSVEK 359


                 ....
gi 499882782  86 VEDA 89
Cdd:PLN03049 360 VSEE 363
 
Name Accession Description Interval E-value
Rv3369 TIGR03667
PPOX class probable F420-dependent enzyme, Rv3369 family; A Genome Properties metabolic ...
 2-131 3.72e-76

PPOX class probable F420-dependent enzyme, Rv3369 family; A Genome Properties metabolic reconstruction for F420 biosynthesis shows that slightly over 10 percent of all prokaryotes with fully sequenced genomes, including about two thirds of the Actinomycetales, make F420. A variant of the Partial Phylogenetic Profiling algorithm, SIMBAL, shows that this protein likely binds F420 in a cleft similar to that in which the homologous enzyme pyridoxamine phosphate oxidase (PPOX) binds FMN. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 132706  Cd Length: 130  Bit Score: 221.96  E-value: 3.72e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499882782    2 AVVEPWVERRLREEKILWLTTVRADGQPQPVPVWFLWGTEGFLIYSRPNAQKLRNIRSNPRVGLNLNCDERGGSVVRAEG 81
Cdd:TIGR03667   1 TEFTAKVARRLREESIVWLTTVRRSGQPQPVPVWFLWDGTEFLIYSRPQAAKLRNIRRNPRVSLHLNSDGRGGDVVVFTG 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 499882782   82 TAEIVEDAAPASEIPEYVQKYREDMRRLGYEPAGFALDYAVAVRVTPRRW 131
Cdd:TIGR03667  81 TAEVVADAPPAREIPAYLAKYREDAARIGMTPERFAADYSVPLRVTPERL 130
YzzA COG3871
General stress protein 26 (function unknown) [Function unknown];
2-134 9.07e-24

General stress protein 26 (function unknown) [Function unknown];


Pssm-ID: 443080 [Multi-domain]  Cd Length: 132  Bit Score: 88.84  E-value: 9.07e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499882782   2 AVVEPWVERRLREEKILWLTTVRADGQPQPVPVWFLWGTEGFLIY--SRPNAQKLRNIRSNPRVGLNLnCDERGGSVVRA 79
Cdd:COG3871    5 EELEEKLWELLEDIRTAMLATVDADGRPHSRPMWFQVDVDDGTLWffTSRDSAKVRNIRRDPRVSLSF-ADPGDDRYVSV 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 499882782  80 EGTAEIVEDAAPASEIPE-YVQKYREDmrrlGYEPAGFALdyavaVRVTPRRWQSW 134
Cdd:COG3871   84 EGTAEIVDDRAKIDELWNpLAEAWFPD----GPDDPDLVL-----LRVTPERAEYW 130
Rv1155_F420 TIGR03618
PPOX class probable F420-dependent enzyme; A Genome Properties metabolic reconstruction for ...
 20-131 8.35e-21

PPOX class probable F420-dependent enzyme; A Genome Properties metabolic reconstruction for F420 biosynthesis shows that slightly over 10 percent of all prokaryotes with fully sequenced genomes, including about two thirds of the Actinomyces, make F420. The Partial Phylogenetic Profiling algorithm identifies this members of this protein family as high-scoring proteins to the F420 biosynthesis profile. A member of this family, Rv1155, was crytallized after expression in Escherichia coli, which does not synthesize F420; the crystal structure shown to resemble FMN-binding proteins, but with a recognizable empty cleft corresponding to, yet differing profounding from, the FMN site of pyridoxine 5'-phosphate oxidase. We propose that this protein family consists of F420-binding enzymes. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 274679 [Multi-domain]  Cd Length: 126  Bit Score: 81.19  E-value: 8.35e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499882782   20 LTTVRADGQPQPVPVWFLWGTEGFLIYSRPNAQKLRNIRSNPRVGLNLNCDERGGSVVRAEGTAEIVEDAAP-ASEIPEY 98
Cdd:TIGR03618  13 LATIRPDGRPQLSPVWFALDGDELVFSTTAGRAKARNLRRDPRVSLSVLDPDGPYRYVEIEGTAEVSPDPDAvRDLVDRL 92

                          90       100       110
                  ....*....|....*....|....*....|...
gi 499882782   99 VQKYREDMRRLGYEPAGfALDYAVAVRVTPRRW 131
Cdd:TIGR03618  93 AERYRGAAGEDEYRRPM-VDPRRVVVRVTPERV 124
Putative_PNPOx pfam01243
Pyridoxamine 5'-phosphate oxidase; Family of domains with putative PNPOx function. Family ...
 4-90 9.11e-20

Pyridoxamine 5'-phosphate oxidase; Family of domains with putative PNPOx function. Family members were predicted to encode pyridoxamine 5'-phosphate oxidase, based on sequence similarity. However, there is no experimental data to validate the predicted activity and purified proteins, such as Swiss:Q06199 and its paralogs, do not possess this activity, nor do they bind to flavin mononucleotide (FMN). To date, the only time functional oxidase activity has been experimentally demonstrated is when the sequences contain both pfam01243 and pfam10590. Moreover, some of the family members that contain both domains have been shown to be involved in phenazine biosynthesis. While some molecular function has been experimentally validated for the proteins containing both domains, the role performed by each domain on its own is unknown.


Pssm-ID: 426149 [Multi-domain]  Cd Length: 88  Bit Score: 77.29  E-value: 9.11e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499882782    4 VEPWVERRLREEKILWLTTVRADGQPQPVPVWFLWG--TEGFLIYSRPNAQKLRNIRSNPRVGLNLnCDERGGSVVRAEG 81
Cdd:pfam01243   1 LTEEIREFLAEPNAVVLATVDKDGRPNVRPVGLKYGfdTVGILFATNTDSRKARNLEENPRVALLF-GDPELRRGVRIEG 79


                  ....*....
gi 499882782   82 TAEIVEDAA 90
Cdd:pfam01243  80 TAEIVTDGE 88
NimA COG3467
Nitroimidazole reductase NimA or a related FMN-containing flavoprotein, pyridoxamine 5 ...
 5-134 2.43e-12

Nitroimidazole reductase NimA or a related FMN-containing flavoprotein, pyridoxamine 5'-phosphate oxidase superfamily [Defense mechanisms];


Pssm-ID: 442690 [Multi-domain]  Cd Length: 144  Bit Score: 59.94  E-value: 2.43e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499882782   5 EPWVERRLREEKILWLTTVRaDGQPQPVPVWFLWGTEGFLIYSRPNAQKLRNIRSNPRVGLNLNCDERGGSV----VRAE 80
Cdd:COG3467   10 REEIRALLDEARVGRLATVD-DGRPYVVPVNYVYDGDTIYFHTAKEGRKLDNLRRNPRVCFEVDELDGLHSTnyrsVVVF 88

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 499882782  81 GTAEIVEDAAPASEIPE-YVQKYREDMRRlgyEPAGFALDYAVAVRVTPRRWQSW 134
Cdd:COG3467   89 GRAEEVEDPEEKARALRlLLEKYAPGRWR---PFSDKELDATAVIRIDPEEISGK 140
Rv2061_F420 TIGR03666
PPOX class probable F420-dependent enzyme, Rv2061 family; A Genome Properties metabolic ...
 11-89 4.12e-09

PPOX class probable F420-dependent enzyme, Rv2061 family; A Genome Properties metabolic reconstruction for F420 biosynthesis shows that slightly over 10 percent of all prokaryotes with fully sequenced genomes, including about two thirds of the Actinomycetales, make F420. A variant of the Partial Phylogenetic Profiling algorithm, SIMBAL, shows that this protein likely binds F420 in a cleft similar to that in which the homologous enzyme pyridoxamine phosphate oxidase (PPOX) binds FMN. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 274712  Cd Length: 132  Bit Score: 51.19  E-value: 4.12e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499882782   11 RLREEKILWLTTVRADGQPQPVPVWFLWGTEGFLIYSRPNAQKLRNIRSNPRVGLNlNCDERG---GSVVraEGTAEIVE 87
Cdd:TIGR03666   8 DLARARYALLTTFRKDGTPVPTPVWAAVDGDKLLVRTKEDSWKVKRIRNNPRVTLA-PCDRRGrptGPVV--PGRARILD 84


                  ..
gi 499882782   88 DA 89
Cdd:TIGR03666  85 GA 86
PPOX_MSMEG_5819 TIGR04023
PPOX class F420-dependent enzyme, MSMEG_5819/OxyR family; A Genome Properties metabolic ...
 20-134 1.91e-07

PPOX class F420-dependent enzyme, MSMEG_5819/OxyR family; A Genome Properties metabolic reconstruction for F420 biosynthesis shows that slightly over 10 percent of all prokaryotes with fully sequenced genomes, including about two thirds of the Actinomycetales, make F420. This subfamily within the PPOX family occurs in at least 19 distinct species of F420 producers and is likely to bind F420 rather than FMN. The member OxyR was shown to use F420 to catalyze a C5a-C11a reduction in oxytetracycline biosynthesis. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 274925  Cd Length: 115  Bit Score: 46.56  E-value: 1.91e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499882782   20 LTTVRADGQPQPVPVWFLWGTEGFLI----YSRPNAQKLRNIRSNPRVGLNLncDE---------RGgsvVRAEGTAEIV 86
Cdd:TIGR04023  17 LATVDPDGQPQVVPVGFEYDGTLGTIdiggYNMSATRKFRNVAANGKVALVV--DDlastdpwrvRG---IEIRGTAEAL 91

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 499882782   87 EDAAPASeIPEYvqkyredmrrlgyepagfaldyavaVRVTPRRWQSW 134
Cdd:TIGR04023  92 TDGGPPG-PGPY-------------------------IRIHPRRIWSW 113
Rv0121_F420 TIGR03668
PPOX class probable F420-dependent enzyme, Rv0121 family; A Genome Properties metabolic ...
 5-134 4.56e-05

PPOX class probable F420-dependent enzyme, Rv0121 family; A Genome Properties metabolic reconstruction for F420 biosynthesis shows that slightly over 10 percent of all prokaryotes with fully sequenced genomes, including about two thirds of the Actinomycetales, make F420. A variant of the Partial Phylogenetic Profiling algorithm, SIMBAL, shows that this protein likely binds F420 in a cleft similar to that in which the homologous enzyme pyridoxamine phosphate oxidase (PPOX) binds FMN. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 132707  Cd Length: 141  Bit Score: 40.59  E-value: 4.56e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499882782    5 EPWVERRLREEKILWLTTVRADGQPQPVPVWFLWGTEGFL-----IY--------SRPNAQKLRNIRSNPRVGLNLNC-D 70
Cdd:TIGR03668   2 EFEARTRFAQARVARLATVSPDGEPHLVPVVFAVGAGAVAagdavIYtavdakpkTTPRLRRLRNIEENPRVSLLVDRyD 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 499882782   71 ERGGSV--VRAEGTAEIVEDAAP--ASEIPEYVQKYREDMRRLGYEPagfaldyavAVRVTPRRWQSW 134
Cdd:TIGR03668  82 DDWTRLwwVRADGRAEILRPGEEehAAAVRLLRAKYHQYQAVPLEGP---------VIAIRVERWASW 140
COG3576 COG3576
Predicted flavin-nucleotide-binding protein, pyridoxine 5'-phosphate oxidase superfamily ...
 54-131 1.13e-03

Predicted flavin-nucleotide-binding protein, pyridoxine 5'-phosphate oxidase superfamily [General function prediction only];


Pssm-ID: 442796  Cd Length: 189  Bit Score: 37.12  E-value: 1.13e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 499882782  54 LRNIRSNPRVGLNLnCDERGGSVVRAEGTAEIVEDAApaseipeyvqkYREDMRRLGYEPagfaldyAVAVRVTPRRW 131
Cdd:COG3576   87 LGNILENPRVGLLF-LDPGRRERLRVNGRARIVTDPA-----------LLARLAVEGKRP-------ERVIVVTVEEV 145
Pyrid_ox_like pfam16242
Pyridoxamine 5'-phosphate oxidase like; This domain, approximately 140 residues in length, is ...
 20-94 3.05e-03

Pyridoxamine 5'-phosphate oxidase like; This domain, approximately 140 residues in length, is mainly found in general stress proteins in various Xanthomonas species. It is composed of a six-stranded antiparallel beta-barrel flanked by five alpha-helices and can bind to FMN and FAD, suggesting that it may help the bacteria to react against the oxidative stress induced by the defense mechanisms of the plant.


Pssm-ID: 435234 [Multi-domain]  Cd Length: 149  Bit Score: 35.38  E-value: 3.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499882782   20 LTTVRADGQPQPVP-----------VWFLwgtegfliySRPNAQKLRNIRSNPRVGLNLNcDERGGSVVRAEGTAEIVED 88
Cdd:pfam16242  18 LTTTTAGGGLHSRPmatqevefdgdLWFF---------TDKDSDKVDEIREDPQVNVAFS-DPSKNNYVSVSGTAEVVRD 87


                  ....*.
gi 499882782   89 AAPASE 94
Cdd:pfam16242  88 RAKIDE 93
PLN03049 PLN03049
pyridoxine (pyridoxamine) 5'-phosphate oxidase; Provisional
 8-89 4.68e-03

pyridoxine (pyridoxamine) 5'-phosphate oxidase; Provisional


Pssm-ID: 215550 [Multi-domain]  Cd Length: 462  Bit Score: 35.60  E-value: 4.68e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499882782   8 VERRLREEKILWLTTVRADGQPQPVPVwFLWGTE--GFLIYSRPNAQKLRNIRSNPRVGLNLNCDERGGSvVRAEGTAEI 85
Cdd:PLN03049 282 VAAGLREPNAMTLATAGEDGRPSARIV-LLKGVDkrGFVWYTNYDSRKAHELSANPKASLVFYWDGLHRQ-VRVEGSVEK 359


                 ....
gi 499882782  86 VEDA 89
Cdd:PLN03049 360 VSEE 363
PPOX_FMN_DR2398 TIGR04025
PPOX class probable FMN-dependent enzyme, DR_2398 family; Members of the PPOX family (see ...
 54-90 4.91e-03

PPOX class probable FMN-dependent enzyme, DR_2398 family; Members of the PPOX family (see pfam01243) may contain either FMN or F420 as cofactor. This subfamily consists of proteins mostly from species that lack the capability to synthesize F420, and therefore most likely all bind FMN.


Pssm-ID: 274926  Cd Length: 197  Bit Score: 35.15  E-value: 4.91e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 499882782   54 LRNIRSNPRVGLNL---NCDErggsVVRAEGTAEIVEDAA 90
Cdd:TIGR04025  81 LRNILRDPRVGLLFlvpGVGE----TLRVNGTARISTDPD 116
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH