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Conserved domains on  [gi|500113337|ref|WP_011789342|]
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MULTISPECIES: IS5-like element ISSpu10 family transposase [Gammaproteobacteria]

Protein Classification

transposase family protein( domain architecture ID 1750073)

transposase family protein might bind to the end of a transposon and catalyze the movement of the transposon to another part of the genome by a cut and paste mechanism or a replicative transposition mechanism

Gene Ontology:  GO:0003677|GO:0006313
PubMed:  21439812

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
transpos_IS5_3 NF033580
IS5 family transposase;
3-248 8.04e-103

IS5 family transposase;


:

Pssm-ID: 468097 [Multi-domain]  Cd Length: 257  Bit Score: 299.10  E-value: 8.04e-103
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500113337   3 RTMLTDEYWSKLIRLM----LKTGRVydKPEHRNTFEGILYRMRVGCPWRDVPEAFGDWSAIYRRFNLWSKKGILMQLFA 78
Cdd:NF033580   2 RSDLTDEQWERIEPLLpparRGGGRR--RVDDREVLNAILYVLRTGCPWRDLPERFGPWSTVYRRFRRWSEAGVWERLFE 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500113337  79 ELRQLA--DLEWEFIDGSIVKAHQHATGARS---EDKEAIGKSRGGNTTKIHMAVDSCGLPIDFIVTGGEVHDSKAAIEL 153
Cdd:NF033580  80 ALLAELriDWERLAIDSTIVRAHQSAAGAKKtgpNGYQAIGRSKGGLKTKIHIAVDALGLPLAFVLTGANVHDSKGALPL 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500113337 154 LKQLP-----DAEHVIADRGYDSEKIREQIREKKGVPNIPRKRNSKigNGDIDWCLYKYRHLVENVFARLKHYRSVATRY 228
Cdd:NF033580 160 LDGLPvlrppRPKHLLADKGYDSDALRAALRERGAVPVIPRRRNRL--RPAYDFRLYKKRWVVERTFAWLKRFRRLATRY 237
                        250       260
                 ....*....|....*....|
gi 500113337 229 DKLARNYASTLALACCLIWL 248
Cdd:NF033580 238 EKLARNFLAFVHLACIRIWL 257
 
Name Accession Description Interval E-value
transpos_IS5_3 NF033580
IS5 family transposase;
3-248 8.04e-103

IS5 family transposase;


Pssm-ID: 468097 [Multi-domain]  Cd Length: 257  Bit Score: 299.10  E-value: 8.04e-103
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500113337   3 RTMLTDEYWSKLIRLM----LKTGRVydKPEHRNTFEGILYRMRVGCPWRDVPEAFGDWSAIYRRFNLWSKKGILMQLFA 78
Cdd:NF033580   2 RSDLTDEQWERIEPLLpparRGGGRR--RVDDREVLNAILYVLRTGCPWRDLPERFGPWSTVYRRFRRWSEAGVWERLFE 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500113337  79 ELRQLA--DLEWEFIDGSIVKAHQHATGARS---EDKEAIGKSRGGNTTKIHMAVDSCGLPIDFIVTGGEVHDSKAAIEL 153
Cdd:NF033580  80 ALLAELriDWERLAIDSTIVRAHQSAAGAKKtgpNGYQAIGRSKGGLKTKIHIAVDALGLPLAFVLTGANVHDSKGALPL 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500113337 154 LKQLP-----DAEHVIADRGYDSEKIREQIREKKGVPNIPRKRNSKigNGDIDWCLYKYRHLVENVFARLKHYRSVATRY 228
Cdd:NF033580 160 LDGLPvlrppRPKHLLADKGYDSDALRAALRERGAVPVIPRRRNRL--RPAYDFRLYKKRWVVERTFAWLKRFRRLATRY 237
                        250       260
                 ....*....|....*....|
gi 500113337 229 DKLARNYASTLALACCLIWL 248
Cdd:NF033580 238 EKLARNFLAFVHLACIRIWL 257
COG3293 COG3293
Transposase [Mobilome: prophages, transposons];
4-100 9.51e-24

Transposase [Mobilome: prophages, transposons];


Pssm-ID: 442522 [Multi-domain]  Cd Length: 98  Bit Score: 91.57  E-value: 9.51e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500113337   4 TMLTDEYWSK---LIRLMLKTGRVYdkPEHRNTFEGILYRMRVGCPWRDVPEAFGDWSAIYRRFNLWSKKGILMQLFAEL 80
Cdd:COG3293    7 VDLTDAQWARiepLLPGPDKGGRPR--HDDREVVNAILYVLRTGCPWRDLPRDFGPWRTVERRFRRWRRLGRWERLAEAL 84
                         90       100
                 ....*....|....*....|
gi 500113337  81 RQLadleweFIDGSIVKAHQ 100
Cdd:COG3293   85 LAA------VIDASSVRAHQ 98
DUF4096 pfam13340
Putative transposase of IS4/5 family (DUF4096);
6-77 3.24e-22

Putative transposase of IS4/5 family (DUF4096);


Pssm-ID: 433130  Cd Length: 76  Bit Score: 86.78  E-value: 3.24e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 500113337    6 LTDEYWSKLIRLMLKTGRVYD----KPEHRNTFEGILYRMRVGCPWRDVPEAFGDWSAIYRRFNLWSKKGILMQLF 77
Cdd:pfam13340   1 LTDEQWARIEPLLPPPKRRGDgrprKHDLREVLNAILYVLRTGCPWRDLPEDFGPWSTVYRRFRRWSRAGVWERLH 76
transpos_IS5_4 NF033581
IS5 family transposase;
37-245 3.83e-18

IS5 family transposase;


Pssm-ID: 468098 [Multi-domain]  Cd Length: 284  Bit Score: 81.21  E-value: 3.83e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500113337  37 ILYRMRVGCPWRDVPeafgDWSAIYRRFNLWSKKGILMQLFAEL-RQLADLEWEF-----IDGSIVKA-HQHATGARSED 109
Cdd:NF033581  63 LSFRAFVGLSEDDVP----DASTIWRFRELLEEHLLAEALFAEVnRQLLAKGLLSkegviVDATLIPApRSPKKRDKKRD 138
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500113337 110 KEAIGKSRGGN---TTKIHMAVDS-CGLPIDFIVTGGEVHDSKAAIELLKqlPDAEHVIADRGYDSEKIREQIREKKGVP 185
Cdd:NF033581 139 PDMRQTKKGKKsrhGYKAHIGVDPkSGLVHSLVTTPANVHDSRAAKELLH--GDEKTVYADKGYDGDEGYQGLREAGVKP 216
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 500113337 186 NIPRK--RNSKIGNGDIdwCLYKY----RHLVENVFARLK-HYRSVATRYDKLARNYASTLALACCL 245
Cdd:NF033581 217 HIPRKksRNRPLTEAQK--RRNRLkskiRARVEHVFGVLKrFFGLSKVRYRGLKRVGARFNLIAALY 281
transpos_IS5_2 NF033579
IS5 family transposase;
17-220 1.53e-17

IS5 family transposase;


Pssm-ID: 468096 [Multi-domain]  Cd Length: 287  Bit Score: 79.64  E-value: 1.53e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500113337  17 LMLKtgrVYDKPEHRNTfEGILYRM--RVGCPWRdVPeafgDWSAIYRRFnlwskKGILMQLFAELRQLADLEWEFIDGS 94
Cdd:NF033579  51 LLLK---VLFGLPLRQT-QGLLNSLfkLIGLDLA-VP----DYSTLCRRF-----KRLKVAIPLSAKLLGGPLHLAIDST 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500113337  95 IVKAHQhatgaRSEDK-EAIGKSRGGNTTKIHMAVDSCGLPI-DFIVTGGEVHDSKAAIELLKQLP-DAEHVIADRGYDS 171
Cdd:NF033579 117 GFKVYG-----EGEWYrRKHGKEKRRQWRKVHLAVDVKTGEIlAVEVTTNKVHDAKVLPDLLRQIPeDIDSVLADGAYDT 191
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 500113337 172 EKIREQIREKKGVPNIPRKRNSKIG------NGDID------------WCLYKYRHLVENVFARLKH 220
Cdd:NF033579 192 KKCHEAIRERGARPLIPPRKNARLWkegkarNAAIReirrlgrelwkkWSGYHRRSLVETAFSRLKR 258
transpos_IS982 NF033520
IS982 family transposase; Currently, there are 46 seed sequences in this family.
61-219 2.24e-12

IS982 family transposase; Currently, there are 46 seed sequences in this family.


Pssm-ID: 468056 [Multi-domain]  Cd Length: 243  Bit Score: 64.56  E-value: 2.24e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500113337  61 YRRFN------LWSKKGILMQLFAELRQLADLeWEFIDGS------IVKAHQHATGArseDKEAIGKSRGGNTT----KI 124
Cdd:NF033520  41 YSRFNrrcrrlLPLIEAIRQELAKKTKSEETG-IAIIDSTpipvchNKRIKRHKVFK---GIADRGYCASKKGWfygfKL 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500113337 125 HMAVDSCGLPIDFIVTGGEVHDSKAAIELLKQLPDAEHVIADRGYDSEKIREQIrEKKGVPNI-PRKRNSKIGN-GDIDW 202
Cdd:NF033520 117 HLLVNLSGEIVSYVITPANVHDRKVLEDLLLTKPLPGKLFGDKGYISKELQEKL-KEQGITLItPLRKNMKEKLeKPNDK 195
                        170
                 ....*....|....*..
gi 500113337 203 CLYKYRHLVENVFARLK 219
Cdd:NF033520 196 LLLRKRKRIETVFSQLK 212
transpos_IS1182 NF033551
IS1182 family transposase; Members of this family are transposases of the IS1182 family. ...
78-207 2.70e-10

IS1182 family transposase; Members of this family are transposases of the IS1182 family. About two-thirds of the members of this family have an extra domain between the middle and the C-terminal domain, about 50 amino acids in size and containing four invariant Cys residues.


Pssm-ID: 468080 [Multi-domain]  Cd Length: 437  Bit Score: 59.65  E-value: 2.70e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500113337  78 AELRQLADLEWEFIDGSIVKAHQHATGARSE------DKEA-IGKSRGGNTT---KIHMAVDS-CGLPIDFIVTGGEVHD 146
Cdd:NF033551 164 LDELELAKEELEASAEAAKQRAEKALLAGKDrrvsttDPDArFMKKSNGGFWfgyNVQIAVDTeSGLIVAVEVTPGNGHD 243
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 500113337 147 SKAAIELLKQLPDA-----EHVIADRGYDSEKIREQIREKKGVPNIPRKRNSKIGNGDIDWCLYKY 207
Cdd:NF033551 244 GGQLIPLLEQVEERlgllpEEVLADAGYGSEENLEALEERGIEPVIPYRRKGAFKPGRFRKDDFRY 309
transpos_IS4_1 NF033592
IS4 family transposase;
58-169 3.81e-08

IS4 family transposase;


Pssm-ID: 468101 [Multi-domain]  Cd Length: 332  Bit Score: 53.04  E-value: 3.81e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500113337  58 SAIYRRFNLwSKKGILMQLFAEL-------RQLADLEWEF-----IDGSIVKAHQHATGARsedkeaigKSRGGNTT--- 122
Cdd:NF033592  67 SALSKARKR-LPVEFLKELFERLlaqlqlgQLLPRKLWRGlrvlaVDGTTIRLPDSLENWA--------PGRGGKNSfpg 137
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 500113337 123 -KIHMAVD-SCGLPIDFIVTGGEVHDSKAAIELLKQLPDAEHVIADRGY 169
Cdd:NF033592 138 vKLHLLYDlLSGLPLDAAITPGKTHERTLLRQLLETLPPGDLLLFDRGY 186
 
Name Accession Description Interval E-value
transpos_IS5_3 NF033580
IS5 family transposase;
3-248 8.04e-103

IS5 family transposase;


Pssm-ID: 468097 [Multi-domain]  Cd Length: 257  Bit Score: 299.10  E-value: 8.04e-103
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500113337   3 RTMLTDEYWSKLIRLM----LKTGRVydKPEHRNTFEGILYRMRVGCPWRDVPEAFGDWSAIYRRFNLWSKKGILMQLFA 78
Cdd:NF033580   2 RSDLTDEQWERIEPLLpparRGGGRR--RVDDREVLNAILYVLRTGCPWRDLPERFGPWSTVYRRFRRWSEAGVWERLFE 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500113337  79 ELRQLA--DLEWEFIDGSIVKAHQHATGARS---EDKEAIGKSRGGNTTKIHMAVDSCGLPIDFIVTGGEVHDSKAAIEL 153
Cdd:NF033580  80 ALLAELriDWERLAIDSTIVRAHQSAAGAKKtgpNGYQAIGRSKGGLKTKIHIAVDALGLPLAFVLTGANVHDSKGALPL 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500113337 154 LKQLP-----DAEHVIADRGYDSEKIREQIREKKGVPNIPRKRNSKigNGDIDWCLYKYRHLVENVFARLKHYRSVATRY 228
Cdd:NF033580 160 LDGLPvlrppRPKHLLADKGYDSDALRAALRERGAVPVIPRRRNRL--RPAYDFRLYKKRWVVERTFAWLKRFRRLATRY 237
                        250       260
                 ....*....|....*....|
gi 500113337 229 DKLARNYASTLALACCLIWL 248
Cdd:NF033580 238 EKLARNFLAFVHLACIRIWL 257
COG3293 COG3293
Transposase [Mobilome: prophages, transposons];
4-100 9.51e-24

Transposase [Mobilome: prophages, transposons];


Pssm-ID: 442522 [Multi-domain]  Cd Length: 98  Bit Score: 91.57  E-value: 9.51e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500113337   4 TMLTDEYWSK---LIRLMLKTGRVYdkPEHRNTFEGILYRMRVGCPWRDVPEAFGDWSAIYRRFNLWSKKGILMQLFAEL 80
Cdd:COG3293    7 VDLTDAQWARiepLLPGPDKGGRPR--HDDREVVNAILYVLRTGCPWRDLPRDFGPWRTVERRFRRWRRLGRWERLAEAL 84
                         90       100
                 ....*....|....*....|
gi 500113337  81 RQLadleweFIDGSIVKAHQ 100
Cdd:COG3293   85 LAA------VIDASSVRAHQ 98
DUF4096 pfam13340
Putative transposase of IS4/5 family (DUF4096);
6-77 3.24e-22

Putative transposase of IS4/5 family (DUF4096);


Pssm-ID: 433130  Cd Length: 76  Bit Score: 86.78  E-value: 3.24e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 500113337    6 LTDEYWSKLIRLMLKTGRVYD----KPEHRNTFEGILYRMRVGCPWRDVPEAFGDWSAIYRRFNLWSKKGILMQLF 77
Cdd:pfam13340   1 LTDEQWARIEPLLPPPKRRGDgrprKHDLREVLNAILYVLRTGCPWRDLPEDFGPWSTVYRRFRRWSRAGVWERLH 76
DDE_Tnp_1 pfam01609
Transposase DDE domain; Transposase proteins are necessary for efficient DNA transposition. ...
91-245 5.28e-19

Transposase DDE domain; Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction. This family contains transposases for IS4, IS421, IS5377, IS427, IS402, IS1355, IS5, which was original isolated in bacteriophage lambda.


Pssm-ID: 376573 [Multi-domain]  Cd Length: 196  Bit Score: 81.91  E-value: 5.28e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500113337   91 IDGSIVKAHQHATGARSEDKEaiGKSRGGntTKIHMAVD-SCGLPIDFIVTGGEVHDSKAAIELLKQLPDAEH--VIADR 167
Cdd:pfam01609   9 IDSTTIRTPGTGEDARWGYDG--GKRRYG--YKLHIAVDtRTGLILAVVLTPGNVHDSKGLLQLLDELRRRKGrlVLADA 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500113337  168 GYDSEKIREQIREKKGVPNIPRKRNSKIGNGDID--------------------------------WCLYKYRHLVENVF 215
Cdd:pfam01609  85 GYGGKELLDKLEEKGVDYLIRLKKNAKLIDDKRRgrlrkhgklkiltkvdklkgrvnstllsaetlAELYRRRWQIERVF 164
                         170       180       190
                  ....*....|....*....|....*....|.
gi 500113337  216 ARLK-HYRSVATRYDKLARNYASTLALACCL 245
Cdd:pfam01609 165 KWLKrVFGLDRLRYRGLNAVEAELLLLALAY 195
transpos_IS5_4 NF033581
IS5 family transposase;
37-245 3.83e-18

IS5 family transposase;


Pssm-ID: 468098 [Multi-domain]  Cd Length: 284  Bit Score: 81.21  E-value: 3.83e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500113337  37 ILYRMRVGCPWRDVPeafgDWSAIYRRFNLWSKKGILMQLFAEL-RQLADLEWEF-----IDGSIVKA-HQHATGARSED 109
Cdd:NF033581  63 LSFRAFVGLSEDDVP----DASTIWRFRELLEEHLLAEALFAEVnRQLLAKGLLSkegviVDATLIPApRSPKKRDKKRD 138
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500113337 110 KEAIGKSRGGN---TTKIHMAVDS-CGLPIDFIVTGGEVHDSKAAIELLKqlPDAEHVIADRGYDSEKIREQIREKKGVP 185
Cdd:NF033581 139 PDMRQTKKGKKsrhGYKAHIGVDPkSGLVHSLVTTPANVHDSRAAKELLH--GDEKTVYADKGYDGDEGYQGLREAGVKP 216
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 500113337 186 NIPRK--RNSKIGNGDIdwCLYKY----RHLVENVFARLK-HYRSVATRYDKLARNYASTLALACCL 245
Cdd:NF033581 217 HIPRKksRNRPLTEAQK--RRNRLkskiRARVEHVFGVLKrFFGLSKVRYRGLKRVGARFNLIAALY 281
transpos_IS5_2 NF033579
IS5 family transposase;
17-220 1.53e-17

IS5 family transposase;


Pssm-ID: 468096 [Multi-domain]  Cd Length: 287  Bit Score: 79.64  E-value: 1.53e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500113337  17 LMLKtgrVYDKPEHRNTfEGILYRM--RVGCPWRdVPeafgDWSAIYRRFnlwskKGILMQLFAELRQLADLEWEFIDGS 94
Cdd:NF033579  51 LLLK---VLFGLPLRQT-QGLLNSLfkLIGLDLA-VP----DYSTLCRRF-----KRLKVAIPLSAKLLGGPLHLAIDST 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500113337  95 IVKAHQhatgaRSEDK-EAIGKSRGGNTTKIHMAVDSCGLPI-DFIVTGGEVHDSKAAIELLKQLP-DAEHVIADRGYDS 171
Cdd:NF033579 117 GFKVYG-----EGEWYrRKHGKEKRRQWRKVHLAVDVKTGEIlAVEVTTNKVHDAKVLPDLLRQIPeDIDSVLADGAYDT 191
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 500113337 172 EKIREQIREKKGVPNIPRKRNSKIG------NGDID------------WCLYKYRHLVENVFARLKH 220
Cdd:NF033579 192 KKCHEAIRERGARPLIPPRKNARLWkegkarNAAIReirrlgrelwkkWSGYHRRSLVETAFSRLKR 258
transpos_IS982 NF033520
IS982 family transposase; Currently, there are 46 seed sequences in this family.
61-219 2.24e-12

IS982 family transposase; Currently, there are 46 seed sequences in this family.


Pssm-ID: 468056 [Multi-domain]  Cd Length: 243  Bit Score: 64.56  E-value: 2.24e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500113337  61 YRRFN------LWSKKGILMQLFAELRQLADLeWEFIDGS------IVKAHQHATGArseDKEAIGKSRGGNTT----KI 124
Cdd:NF033520  41 YSRFNrrcrrlLPLIEAIRQELAKKTKSEETG-IAIIDSTpipvchNKRIKRHKVFK---GIADRGYCASKKGWfygfKL 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500113337 125 HMAVDSCGLPIDFIVTGGEVHDSKAAIELLKQLPDAEHVIADRGYDSEKIREQIrEKKGVPNI-PRKRNSKIGN-GDIDW 202
Cdd:NF033520 117 HLLVNLSGEIVSYVITPANVHDRKVLEDLLLTKPLPGKLFGDKGYISKELQEKL-KEQGITLItPLRKNMKEKLeKPNDK 195
                        170
                 ....*....|....*..
gi 500113337 203 CLYKYRHLVENVFARLK 219
Cdd:NF033520 196 LLLRKRKRIETVFSQLK 212
IS5 COG3039
Transposase and inactivated derivatives, IS5 family [Mobilome: prophages, transposons];
63-248 2.29e-12

Transposase and inactivated derivatives, IS5 family [Mobilome: prophages, transposons];


Pssm-ID: 442273 [Multi-domain]  Cd Length: 316  Bit Score: 65.28  E-value: 2.29e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500113337  63 RF-NLWSKKGILMQLFAEL-RQLADLEWEF-----IDGSIVKAH-QHATGARSEDKEAIGKSRGGNTT---KIHMAVDS- 130
Cdd:COG3039  107 RFrHLLEEHGLGEALFEEVnAQLSEKGLILrkgtiVDATIIAAPsSTKNKDRQRDPDAHQTKKGNQWYfgyKAHIGVDAd 186
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500113337 131 CGLPIDFIVTGGEVHDSKAAIELLKQlpDAEHVIADRGYDSEKIREQIREKKGVPNIPRK--RNSKIGNGD--IDWCLYK 206
Cdd:COG3039  187 SGLIHTVVTTAANVHDVTHLDELLHG--EETDVYADKGYQGAEKREELKARGIRWHIARKpgRNKPLSELQkrRNRRKAK 264
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 500113337 207 YRHLVENVFARLK-HYRSVATRYDKLARN-YASTLALACCLIWL 248
Cdd:COG3039  265 VRAKVEHPFGVIKrLFGYKKVRYRGLAKNtAQLFLLAALYNLKR 308
transpos_IS1182 NF033551
IS1182 family transposase; Members of this family are transposases of the IS1182 family. ...
78-207 2.70e-10

IS1182 family transposase; Members of this family are transposases of the IS1182 family. About two-thirds of the members of this family have an extra domain between the middle and the C-terminal domain, about 50 amino acids in size and containing four invariant Cys residues.


Pssm-ID: 468080 [Multi-domain]  Cd Length: 437  Bit Score: 59.65  E-value: 2.70e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500113337  78 AELRQLADLEWEFIDGSIVKAHQHATGARSE------DKEA-IGKSRGGNTT---KIHMAVDS-CGLPIDFIVTGGEVHD 146
Cdd:NF033551 164 LDELELAKEELEASAEAAKQRAEKALLAGKDrrvsttDPDArFMKKSNGGFWfgyNVQIAVDTeSGLIVAVEVTPGNGHD 243
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 500113337 147 SKAAIELLKQLPDA-----EHVIADRGYDSEKIREQIREKKGVPNIPRKRNSKIGNGDIDWCLYKY 207
Cdd:NF033551 244 GGQLIPLLEQVEERlgllpEEVLADAGYGSEENLEALEERGIEPVIPYRRKGAFKPGRFRKDDFRY 309
transpos_IS4_1 NF033592
IS4 family transposase;
58-169 3.81e-08

IS4 family transposase;


Pssm-ID: 468101 [Multi-domain]  Cd Length: 332  Bit Score: 53.04  E-value: 3.81e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500113337  58 SAIYRRFNLwSKKGILMQLFAEL-------RQLADLEWEF-----IDGSIVKAHQHATGARsedkeaigKSRGGNTT--- 122
Cdd:NF033592  67 SALSKARKR-LPVEFLKELFERLlaqlqlgQLLPRKLWRGlrvlaVDGTTIRLPDSLENWA--------PGRGGKNSfpg 137
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 500113337 123 -KIHMAVD-SCGLPIDFIVTGGEVHDSKAAIELLKQLPDAEHVIADRGY 169
Cdd:NF033592 138 vKLHLLYDlLSGLPLDAAITPGKTHERTLLRQLLETLPPGDLLLFDRGY 186
DDE_Tnp_1_2 pfam13586
Transposase DDE domain; Transposase proteins are necessary for efficient DNA transposition. ...
163-248 7.26e-08

Transposase DDE domain; Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis.


Pssm-ID: 463928 [Multi-domain]  Cd Length: 90  Bit Score: 48.95  E-value: 7.26e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500113337  163 VIADRGYDSEKIREQIRE---KKGVPNIPRKRNSKIGNGDIDWCLYKYRHLVENVFARLKHYRSVATRYDKLARNYASTL 239
Cdd:pfam13586   1 VHVDRGYRTRHNREWLKErgiRASGPPLGRPAKNKAQEKKQAREDEIARNVIEGKFGWFKRRRSLAKRYEKLASTFEGAI 80

                  ....*....
gi 500113337  240 ALACCLIWL 248
Cdd:pfam13586  81 ALTFLVINL 89
DDE_Tnp_4 pfam13359
DDE superfamily endonuclease; This family of proteins are related to pfam00665 and are ...
117-245 1.97e-06

DDE superfamily endonuclease; This family of proteins are related to pfam00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction.


Pssm-ID: 463855 [Multi-domain]  Cd Length: 158  Bit Score: 46.50  E-value: 1.97e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500113337  117 RGGNTTKIHMAVDSCGLPIDFIVT-GGEVHDSKAAIE--LLKQL----PDAEHVIADRGYD-SEKIR--EQIREKKGVPN 186
Cdd:pfam13359  25 KHHNTLKVLIVVTPNGKIIFVSKGyPGSVSDKSILENsgLLKALnlafGPGDYILADKGFPiSDWLLvpYKKPGGAQLSP 104
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 500113337  187 IPRKRNSKIGngdidwclyKYRHLVENVFARLKH-YRSVATRYD-KLARNYASTLALACCL 245
Cdd:pfam13359 105 EEVEFNRRIA---------SARIHVERVIGRLKGrFRILRGRLPiSLPERLDKIVTVCCVL 156
DDE_Tnp_1_3 pfam13612
Transposase DDE domain; Transposase proteins are necessary for efficient DNA transposition. ...
117-219 7.13e-06

Transposase DDE domain; Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contains three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction.


Pssm-ID: 433348  Cd Length: 154  Bit Score: 44.62  E-value: 7.13e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500113337  117 RGGNTT------KIHMAVDSCGLPIDFIVTGGEVHDSKAAIELLKQLPDaeHVIADRGYDSEKIREQIREkKGVPNIPRK 190
Cdd:pfam13612  34 RGKSSMgwfygfKLHLIINDRGEILAFKLTPGNVDDRKPVETLSKGLFG--KLFGDKGYISQKLFDQLLE-DGIELITNL 110
                          90       100       110
                  ....*....|....*....|....*....|..
gi 500113337  191 RNsKIGNGDI---DWCLYKYRHLVENVFARLK 219
Cdd:pfam13612 111 RK-NMKNKLMslwDKALLRKRSLIETVNDQLK 141
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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