NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|500215625|ref|WP_011885776|]
View 

MULTISPECIES: bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase CoaBC [Burkholderia]

Protein Classification

bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase( domain architecture ID 11418829)

bifunctional phosphopantothenoylcysteine decarboxylase (CoaC)/phosphopantothenate synthase (CoaB) catalyzes two steps in the biosynthesis of coenzyme A, the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, followed by its decarboxylation to form 4'-phosphopantotheine

EC:  4.1.1.36|6.3.2.5
Gene Ontology:  GO:0071513|GO:0010181|GO:0046872|GO:0004632|GO:0004633|GO:0015937|GO:0015941

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
CoaBC COG0452
Phosphopantothenoylcysteine synthetase/decarboxylase CoaBC [Coenzyme transport and metabolism]; ...
 6-399 0e+00

Phosphopantothenoylcysteine synthetase/decarboxylase CoaBC [Coenzyme transport and metabolism]; Phosphopantothenoylcysteine synthetase/decarboxylase CoaBC is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis


:

Pssm-ID: 440221 [Multi-domain]  Cd Length: 399  Bit Score: 643.62  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500215625   6 LAGKHLVLGLTGGIACYKIAELTRLLTKAGATVQVVMTEAAAQFITPVTMQALSGRPVYTSQWDARVDNNMAHIDLSREA 85
Cdd:COG0452    2 LAGKRILLGVTGGIAAYKAAELVRLLRKAGAEVRVVMTEAATEFVTPLTFQALSGNPVYTDLFDEEAEAEMGHIELARWA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500215625  86 DAIVIAPASTDFLAKLAHGFADDLLSTLCVARDCPLLVVPAMNRQMWQNPATQRNAAQLRADGVSVLGPDSGAQACGEVG 165
Cdd:COG0452   82 DLIVIAPATANTIAKLAHGIADDLLTTTLLATTCPVLVAPAMNTNMWEHPATQRNLATLRERGVHIIGPASGELACGDVG 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500215625 166 DGRMLEPEAIYEAIVAHFAPK-LLAHRRVLITAGPTFEPLDPVRGLTNRSSGKMGFALARAAQQAGADVHLVAGPVALDT 244
Cdd:COG0452  162 KGRMAEPEEIVEAIEALLAPKkDLAGKKVLITAGPTREPIDPVRFISNRSSGKMGYALAEAAAARGAEVTLVSGPVALPT 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500215625 245 PWGVYRQDVQTAQQMYDAVMHAVSDADIFIAVAAVADWRVEQPAEHKMKKTADrkMPALTFVENPDILASVAALPDP-PY 323
Cdd:COG0452  242 PAGVERIDVESAEEMLEAVLAAFPDADIVIMAAAVADYRPAEVADQKIKKTDD--PLTLELVKNPDILAELGARKKPgQF 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500215625 324 CVGFAAESGDLDVHGDEKRKRKNVPLLIGNL---GPLTFGRDDNEVVLFEAAGL-TPLPRAPKDELAHVLVAEIARRLPD 399
Cdd:COG0452  320 LVGFAAETENLLENARAKLARKNLDLIVANDvsdAGAGFGSDTNAVTLLDKDGReEELPLMSKLEVARRILDEIAELLAA 399
 
Name Accession Description Interval E-value
CoaBC COG0452
Phosphopantothenoylcysteine synthetase/decarboxylase CoaBC [Coenzyme transport and metabolism]; ...
 6-399 0e+00

Phosphopantothenoylcysteine synthetase/decarboxylase CoaBC [Coenzyme transport and metabolism]; Phosphopantothenoylcysteine synthetase/decarboxylase CoaBC is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis


Pssm-ID: 440221 [Multi-domain]  Cd Length: 399  Bit Score: 643.62  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500215625   6 LAGKHLVLGLTGGIACYKIAELTRLLTKAGATVQVVMTEAAAQFITPVTMQALSGRPVYTSQWDARVDNNMAHIDLSREA 85
Cdd:COG0452    2 LAGKRILLGVTGGIAAYKAAELVRLLRKAGAEVRVVMTEAATEFVTPLTFQALSGNPVYTDLFDEEAEAEMGHIELARWA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500215625  86 DAIVIAPASTDFLAKLAHGFADDLLSTLCVARDCPLLVVPAMNRQMWQNPATQRNAAQLRADGVSVLGPDSGAQACGEVG 165
Cdd:COG0452   82 DLIVIAPATANTIAKLAHGIADDLLTTTLLATTCPVLVAPAMNTNMWEHPATQRNLATLRERGVHIIGPASGELACGDVG 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500215625 166 DGRMLEPEAIYEAIVAHFAPK-LLAHRRVLITAGPTFEPLDPVRGLTNRSSGKMGFALARAAQQAGADVHLVAGPVALDT 244
Cdd:COG0452  162 KGRMAEPEEIVEAIEALLAPKkDLAGKKVLITAGPTREPIDPVRFISNRSSGKMGYALAEAAAARGAEVTLVSGPVALPT 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500215625 245 PWGVYRQDVQTAQQMYDAVMHAVSDADIFIAVAAVADWRVEQPAEHKMKKTADrkMPALTFVENPDILASVAALPDP-PY 323
Cdd:COG0452  242 PAGVERIDVESAEEMLEAVLAAFPDADIVIMAAAVADYRPAEVADQKIKKTDD--PLTLELVKNPDILAELGARKKPgQF 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500215625 324 CVGFAAESGDLDVHGDEKRKRKNVPLLIGNL---GPLTFGRDDNEVVLFEAAGL-TPLPRAPKDELAHVLVAEIARRLPD 399
Cdd:COG0452  320 LVGFAAETENLLENARAKLARKNLDLIVANDvsdAGAGFGSDTNAVTLLDKDGReEELPLMSKLEVARRILDEIAELLAA 399
PRK05579 PRK05579
bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated
 3-399 0e+00

bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated


Pssm-ID: 235513 [Multi-domain]  Cd Length: 399  Bit Score: 633.33  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500215625   3 HAELAGKHLVLGLTGGIACYKIAELTRLLTKAGATVQVVMTEAAAQFITPVTMQALSGRPVYTSQWDARVDNNMAHIDLS 82
Cdd:PRK05579   1 MRMLAGKRIVLGVSGGIAAYKALELVRRLRKAGADVRVVMTEAAKKFVTPLTFQALSGNPVSTDLWDPAAEAAMGHIELA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500215625  83 READAIVIAPASTDFLAKLAHGFADDLLSTLCVARDCPLLVVPAMNRQMWQNPATQRNAAQLRADGVSVLGPDSGAQACG 162
Cdd:PRK05579  81 KWADLVLIAPATADLIAKLAHGIADDLLTTTLLATTAPVLVAPAMNTQMWENPATQRNLATLRSRGVEIIGPASGRLACG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500215625 163 EVGDGRMLEPEAIYEAIVAHFAPKLLAHRRVLITAGPTFEPLDPVRGLTNRSSGKMGFALARAAQQAGADVHLVAGPVAL 242
Cdd:PRK05579 161 DVGPGRMAEPEEIVAAAERALSPKDLAGKRVLITAGPTREPIDPVRYITNRSSGKMGYALARAAARRGADVTLVSGPVNL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500215625 243 DTPWGVYRQDVQTAQQMYDAVMHAVSDADIFIAVAAVADWRVEQPAEHKMKKTADrkMPALTFVENPDILASVAAL-PDP 321
Cdd:PRK05579 241 PTPAGVKRIDVESAQEMLDAVLAALPQADIFIMAAAVADYRPATVAEGKIKKGEG--ELTLELVPNPDILAEVAALkDKR 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500215625 322 PYCVGFAAESGDLDVHGDEKRKRKNVPLLIGNL--GPLTFGRDDNEVVLFEAAG-LTPLPRAPKDELAHVLVAEIARRLP 398
Cdd:PRK05579 319 PFVVGFAAETGDVLEYARAKLKRKGLDLIVANDvsAGGGFGSDDNEVTLIWSDGgEVKLPLMSKLELARRLLDEIAERLL 398


                 .
gi 500215625 399 D 399
Cdd:PRK05579 399 E 399
coaBC_dfp TIGR00521
phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase; This model ...
 6-394 3.03e-150

phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase; This model represents a bifunctional enzyme that catalyzes the second and third steps (cysteine ligation, EC 6.3.2.5, and decarboxylation, EC 4.1.1.36) in the biosynthesis of coenzyme A (CoA) from pantothenate in bacteria. In early descriptions of this flavoprotein, a ts mutation in one region of the protein appeared to cause a defect in DNA metaobolism rather than an increased need for the pantothenate precursor beta-alanine. This protein was then called dfp, for DNA/pantothenate metabolism flavoprotein. The authors responsible for detecting phosphopantothenate--cysteine ligase activity suggest renaming this bifunctional protein coaBC for its role in CoA biosynthesis. This enzyme contains the FMN cofactor, but no FAD or pyruvoyl group. The amino-terminal region contains the phosphopantothenoylcysteine decarboxylase activity. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pantothenate and coenzyme A]


Pssm-ID: 273116 [Multi-domain]  Cd Length: 391  Bit Score: 430.64  E-value: 3.03e-150
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500215625    6 LAGKHLVLGLTGGIACYKIAELTRLLTKAGATVQVVMTEAAAQFITPVTMQALSGRPVYTSQWDARVDNNMaHIDLSREA 85
Cdd:TIGR00521   1 LENKKILLGVTGGIAAYKTVELVRELVRQGAEVKVIMTEAAKKFITPLTLEALSGHKVVTELWGPIEHNAL-HIDLAKWA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500215625   86 DAIVIAPASTDFLAKLAHGFADDLLSTLCVARDCPLLVVPAMNRQMWQNPATQRNAAQLRADGVSVLGPDSGAQACGEVG 165
Cdd:TIGR00521  80 DLILIAPATANTISKIAHGIADDLVSTTALAASAPIILAPAMNENMYNNPAVQENIKRLKDDGYIFIEPRSGLLACGDEG 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500215625  166 DGRMLEPEAIYEAIVAHFAPKL-LAHRRVLITAGPTFEPLDPVRGLTNRSSGKMGFALARAAQQAGADVHLVAGPVALDT 244
Cdd:TIGR00521 160 KGRLAEPETIVKAAEREFSPKEdLEGKRVLITAGPTREPIDPVRFISNLSSGKMGLALAEAAYKRGADVTLITGPVSLLT 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500215625  245 PWGVYRQDVQTAQQMYDAVMH-AVSDADIFIAVAAVADWRVEQPAEHKMKKTADRKmpALTFVENPDILASVAALPDPPY 323
Cdd:TIGR00521 240 PPGVKSIKVSTAEEMLEAALNeLAKDFDIFISAAAVADFKPKTVFEGKIKKQGEEL--SLKLVKNPDIIAEVRKIKKHQV 317

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 500215625  324 CVGFAAESG-DLDVHGDEKRKRKNVPLLIGNL--GPLTFGRDDNEVVLFEAAGLTPLPRAPKDELAHVLVAEIA 394
Cdd:TIGR00521 318 IVGFKAETNdDLIKYAKEKLKKKNLDMIVANDvsQGRGFGSDENEVYIFSKHGHKELPLMSKLEVAERILDEIK 391
DFP pfam04127
DNA / pantothenate metabolism flavoprotein; The DNA/pantothenate metabolism flavoprotein (EC:4. ...
 188-367 1.01e-91

DNA / pantothenate metabolism flavoprotein; The DNA/pantothenate metabolism flavoprotein (EC:4.1.1.36) affects synthesis of DNA, and pantothenate metabolism.


Pssm-ID: 461186 [Multi-domain]  Cd Length: 183  Bit Score: 273.90  E-value: 1.01e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500215625  188 LAHRRVLITAGPTFEPLDPVRGLTNRSSGKMGFALARAAQQAGADVHLVAGPVALDTPWGVYRQDVQTAQQMYDAVMHAV 267
Cdd:pfam04127   1 LAGKRVLVTAGPTREPIDPVRFISNRSSGKMGYALARAAAARGAEVTLVSGPTSLPPPPGVEVVDVESAEEMLEAVLAAF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500215625  268 SDADIFIAVAAVADWRVEQPAEHKMKKTADRKMPALTFVENPDILASVAALPDPPYCVGFAAESGDLDVHGDEKRKRKNV 347
Cdd:pfam04127  81 PEADIVIMAAAVADYRPAEVADGKIKKSSGGEELTLELVKNPDILAELGKRKPGQLLVGFAAETEDLLENARAKLERKNL 160

                         170       180
                  ....*....|....*....|...
gi 500215625  348 PLLIGNL---GPLTFGRDDNEVV 367
Cdd:pfam04127 161 DLIVANDvsrPGAGFGSDTNEVT 183
 
Name Accession Description Interval E-value
CoaBC COG0452
Phosphopantothenoylcysteine synthetase/decarboxylase CoaBC [Coenzyme transport and metabolism]; ...
 6-399 0e+00

Phosphopantothenoylcysteine synthetase/decarboxylase CoaBC [Coenzyme transport and metabolism]; Phosphopantothenoylcysteine synthetase/decarboxylase CoaBC is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis


Pssm-ID: 440221 [Multi-domain]  Cd Length: 399  Bit Score: 643.62  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500215625   6 LAGKHLVLGLTGGIACYKIAELTRLLTKAGATVQVVMTEAAAQFITPVTMQALSGRPVYTSQWDARVDNNMAHIDLSREA 85
Cdd:COG0452    2 LAGKRILLGVTGGIAAYKAAELVRLLRKAGAEVRVVMTEAATEFVTPLTFQALSGNPVYTDLFDEEAEAEMGHIELARWA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500215625  86 DAIVIAPASTDFLAKLAHGFADDLLSTLCVARDCPLLVVPAMNRQMWQNPATQRNAAQLRADGVSVLGPDSGAQACGEVG 165
Cdd:COG0452   82 DLIVIAPATANTIAKLAHGIADDLLTTTLLATTCPVLVAPAMNTNMWEHPATQRNLATLRERGVHIIGPASGELACGDVG 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500215625 166 DGRMLEPEAIYEAIVAHFAPK-LLAHRRVLITAGPTFEPLDPVRGLTNRSSGKMGFALARAAQQAGADVHLVAGPVALDT 244
Cdd:COG0452  162 KGRMAEPEEIVEAIEALLAPKkDLAGKKVLITAGPTREPIDPVRFISNRSSGKMGYALAEAAAARGAEVTLVSGPVALPT 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500215625 245 PWGVYRQDVQTAQQMYDAVMHAVSDADIFIAVAAVADWRVEQPAEHKMKKTADrkMPALTFVENPDILASVAALPDP-PY 323
Cdd:COG0452  242 PAGVERIDVESAEEMLEAVLAAFPDADIVIMAAAVADYRPAEVADQKIKKTDD--PLTLELVKNPDILAELGARKKPgQF 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500215625 324 CVGFAAESGDLDVHGDEKRKRKNVPLLIGNL---GPLTFGRDDNEVVLFEAAGL-TPLPRAPKDELAHVLVAEIARRLPD 399
Cdd:COG0452  320 LVGFAAETENLLENARAKLARKNLDLIVANDvsdAGAGFGSDTNAVTLLDKDGReEELPLMSKLEVARRILDEIAELLAA 399
PRK05579 PRK05579
bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated
 3-399 0e+00

bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated


Pssm-ID: 235513 [Multi-domain]  Cd Length: 399  Bit Score: 633.33  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500215625   3 HAELAGKHLVLGLTGGIACYKIAELTRLLTKAGATVQVVMTEAAAQFITPVTMQALSGRPVYTSQWDARVDNNMAHIDLS 82
Cdd:PRK05579   1 MRMLAGKRIVLGVSGGIAAYKALELVRRLRKAGADVRVVMTEAAKKFVTPLTFQALSGNPVSTDLWDPAAEAAMGHIELA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500215625  83 READAIVIAPASTDFLAKLAHGFADDLLSTLCVARDCPLLVVPAMNRQMWQNPATQRNAAQLRADGVSVLGPDSGAQACG 162
Cdd:PRK05579  81 KWADLVLIAPATADLIAKLAHGIADDLLTTTLLATTAPVLVAPAMNTQMWENPATQRNLATLRSRGVEIIGPASGRLACG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500215625 163 EVGDGRMLEPEAIYEAIVAHFAPKLLAHRRVLITAGPTFEPLDPVRGLTNRSSGKMGFALARAAQQAGADVHLVAGPVAL 242
Cdd:PRK05579 161 DVGPGRMAEPEEIVAAAERALSPKDLAGKRVLITAGPTREPIDPVRYITNRSSGKMGYALARAAARRGADVTLVSGPVNL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500215625 243 DTPWGVYRQDVQTAQQMYDAVMHAVSDADIFIAVAAVADWRVEQPAEHKMKKTADrkMPALTFVENPDILASVAAL-PDP 321
Cdd:PRK05579 241 PTPAGVKRIDVESAQEMLDAVLAALPQADIFIMAAAVADYRPATVAEGKIKKGEG--ELTLELVPNPDILAEVAALkDKR 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500215625 322 PYCVGFAAESGDLDVHGDEKRKRKNVPLLIGNL--GPLTFGRDDNEVVLFEAAG-LTPLPRAPKDELAHVLVAEIARRLP 398
Cdd:PRK05579 319 PFVVGFAAETGDVLEYARAKLKRKGLDLIVANDvsAGGGFGSDDNEVTLIWSDGgEVKLPLMSKLELARRLLDEIAERLL 398


                 .
gi 500215625 399 D 399
Cdd:PRK05579 399 E 399
coaBC_dfp TIGR00521
phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase; This model ...
 6-394 3.03e-150

phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase; This model represents a bifunctional enzyme that catalyzes the second and third steps (cysteine ligation, EC 6.3.2.5, and decarboxylation, EC 4.1.1.36) in the biosynthesis of coenzyme A (CoA) from pantothenate in bacteria. In early descriptions of this flavoprotein, a ts mutation in one region of the protein appeared to cause a defect in DNA metaobolism rather than an increased need for the pantothenate precursor beta-alanine. This protein was then called dfp, for DNA/pantothenate metabolism flavoprotein. The authors responsible for detecting phosphopantothenate--cysteine ligase activity suggest renaming this bifunctional protein coaBC for its role in CoA biosynthesis. This enzyme contains the FMN cofactor, but no FAD or pyruvoyl group. The amino-terminal region contains the phosphopantothenoylcysteine decarboxylase activity. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pantothenate and coenzyme A]


Pssm-ID: 273116 [Multi-domain]  Cd Length: 391  Bit Score: 430.64  E-value: 3.03e-150
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500215625    6 LAGKHLVLGLTGGIACYKIAELTRLLTKAGATVQVVMTEAAAQFITPVTMQALSGRPVYTSQWDARVDNNMaHIDLSREA 85
Cdd:TIGR00521   1 LENKKILLGVTGGIAAYKTVELVRELVRQGAEVKVIMTEAAKKFITPLTLEALSGHKVVTELWGPIEHNAL-HIDLAKWA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500215625   86 DAIVIAPASTDFLAKLAHGFADDLLSTLCVARDCPLLVVPAMNRQMWQNPATQRNAAQLRADGVSVLGPDSGAQACGEVG 165
Cdd:TIGR00521  80 DLILIAPATANTISKIAHGIADDLVSTTALAASAPIILAPAMNENMYNNPAVQENIKRLKDDGYIFIEPRSGLLACGDEG 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500215625  166 DGRMLEPEAIYEAIVAHFAPKL-LAHRRVLITAGPTFEPLDPVRGLTNRSSGKMGFALARAAQQAGADVHLVAGPVALDT 244
Cdd:TIGR00521 160 KGRLAEPETIVKAAEREFSPKEdLEGKRVLITAGPTREPIDPVRFISNLSSGKMGLALAEAAYKRGADVTLITGPVSLLT 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500215625  245 PWGVYRQDVQTAQQMYDAVMH-AVSDADIFIAVAAVADWRVEQPAEHKMKKTADRKmpALTFVENPDILASVAALPDPPY 323
Cdd:TIGR00521 240 PPGVKSIKVSTAEEMLEAALNeLAKDFDIFISAAAVADFKPKTVFEGKIKKQGEEL--SLKLVKNPDIIAEVRKIKKHQV 317

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 500215625  324 CVGFAAESG-DLDVHGDEKRKRKNVPLLIGNL--GPLTFGRDDNEVVLFEAAGLTPLPRAPKDELAHVLVAEIA 394
Cdd:TIGR00521 318 IVGFKAETNdDLIKYAKEKLKKKNLDMIVANDvsQGRGFGSDENEVYIFSKHGHKELPLMSKLEVAERILDEIK 391
PRK13982 PRK13982
bifunctional SbtC-like/phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; ...
 4-399 1.73e-132

bifunctional SbtC-like/phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Provisional


Pssm-ID: 172484 [Multi-domain]  Cd Length: 475  Bit Score: 388.73  E-value: 1.73e-132
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500215625   4 AELAGKHLVLGLTGGIACYKIAELTRLLTKAGATVQVVMTEAAAQFITPVTMQALSGRPVYTSQWDARVDNNMAHIDLSR 83
Cdd:PRK13982  66 ASLASKRVTLIIGGGIAAYKALDLIRRLKERGAHVRCVLTKAAQQFVTPLTASALSGQRVYTDLFDPESEFDAGHIRLAR 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500215625  84 EADAIVIAPASTDFLAKLAHGFADDLLSTLCVARDCPLLVVPAMNRQMWQNPATQRNAAQLRADGVSVLGPDSGAQA-CG 162
Cdd:PRK13982 146 DCDLIVVAPATADLMAKMANGLADDLASAILLAANRPILLAPAMNPLMWNNPATRRNVAQLKRDGVHMIGPNAGEMAeRG 225

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500215625 163 EVGDGRMLEPEAIYEAIVAHFAP---KLLAHRRVLITAGPTFEPLDPVRGLTNRSSGKMGFALARAAQQAGADVHLVAGP 239
Cdd:PRK13982 226 EAGVGRMAEPLEIAAAAEALLRPpqpKPLAGRRVLITAGPTHEPIDPVRYIANRSSGKQGFAIAAAAAAAGAEVTLISGP 305

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500215625 240 VALDTPWGVYRQDVQTAQQMYDAVMHAVSdADIFIAVAAVADWRVEQPAEHKMKKTADrKMPALTFVENPDILASVAALP 319
Cdd:PRK13982 306 VDLADPQGVKVIHVESARQMLAAVEAALP-ADIAIFAAAVADWRVATEGGQKLKKGAA-GPPPLQLVENPDILATISKLA 383

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500215625 320 D--PPYCVGFAAESGDLDVHGDEKRKRKNVPLLIGN-LGPLT--FGRDDNEVVLF----EAAGLTPLPRAPKDELAHVLV 390
Cdd:PRK13982 384 EnrPPLVIGFAAETEHLIDNARAKLARKGCDWIVANdVSPATgvMGGDRNTVHLLsrdgDAEKVESWPVMTKDEVATALV 463


                 ....*....
gi 500215625 391 AEIARRLPD 399
Cdd:PRK13982 464 ARIASTFTT 472
DFP pfam04127
DNA / pantothenate metabolism flavoprotein; The DNA/pantothenate metabolism flavoprotein (EC:4. ...
 188-367 1.01e-91

DNA / pantothenate metabolism flavoprotein; The DNA/pantothenate metabolism flavoprotein (EC:4.1.1.36) affects synthesis of DNA, and pantothenate metabolism.


Pssm-ID: 461186 [Multi-domain]  Cd Length: 183  Bit Score: 273.90  E-value: 1.01e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500215625  188 LAHRRVLITAGPTFEPLDPVRGLTNRSSGKMGFALARAAQQAGADVHLVAGPVALDTPWGVYRQDVQTAQQMYDAVMHAV 267
Cdd:pfam04127   1 LAGKRVLVTAGPTREPIDPVRFISNRSSGKMGYALARAAAARGAEVTLVSGPTSLPPPPGVEVVDVESAEEMLEAVLAAF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500215625  268 SDADIFIAVAAVADWRVEQPAEHKMKKTADRKMPALTFVENPDILASVAALPDPPYCVGFAAESGDLDVHGDEKRKRKNV 347
Cdd:pfam04127  81 PEADIVIMAAAVADYRPAEVADGKIKKSSGGEELTLELVKNPDILAELGKRKPGQLLVGFAAETEDLLENARAKLERKNL 160

                         170       180
                  ....*....|....*....|...
gi 500215625  348 PLLIGNL---GPLTFGRDDNEVV 367
Cdd:pfam04127 161 DLIVANDvsrPGAGFGSDTNEVT 183
PRK07313 PRK07313
phosphopantothenoylcysteine decarboxylase; Validated
 8-186 6.52e-73

phosphopantothenoylcysteine decarboxylase; Validated


Pssm-ID: 235986 [Multi-domain]  Cd Length: 182  Bit Score: 225.60  E-value: 6.52e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500215625   8 GKHLVLGLTGGIACYKIAELTRLLTKAGATVQVVMTEAAAQFITPVTMQALSGRPVYTSQWDARVDNNMAHIDLSREADA 87
Cdd:PRK07313   1 MKNILLAVSGSIAAYKAADLTSQLTKRGYQVTVLMTKAATKFITPLTLQVLSKNPVHLDVMDEHDPKLMNHIELAKRADL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500215625  88 IVIAPASTDFLAKLAHGFADDLLST--LCVARDCPLLVVPAMNRQMWQNPATQRNAAQLRADGVSVLGPDSGAQACGEVG 165
Cdd:PRK07313  81 FLVAPATANTIAKLAHGIADDLVTSvaLALPATTPKLIAPAMNTKMYENPATQRNLKTLKEDGVQEIEPKEGLLACGDEG 160

                        170       180
                 ....*....|....*....|.
gi 500215625 166 DGRMLEPEAIYEAIVAHFAPK 186
Cdd:PRK07313 161 YGALADIETILETIENTLKEK 181
coaC_strep TIGR02113
phosphopantothenoylcysteine decarboxylase, streptococcal; In most bacteria, a single ...
 9-179 1.35e-46

phosphopantothenoylcysteine decarboxylase, streptococcal; In most bacteria, a single bifunctional protein catalyses phosphopantothenoylcysteine decarboxylase and phosphopantothenate--cysteine ligase activities, sequential steps in coenzyme A biosynthesis (see TIGR00521). These activities reside in separate proteins encoded by tandem genes in some bacterial lineages. This model describes proteins from the genera Streptococcus and Enterococcus homologous to the N-terminal region of TIGR00521, corresponding to phosphopantothenoylcysteine decarboxylase activity. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pantothenate and coenzyme A]


Pssm-ID: 131168  Cd Length: 177  Bit Score: 157.67  E-value: 1.35e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500215625    9 KHLVLGLTGGIACYKIAELTRLLTKAGATVQVVMTEAAAQFITPVTMQALSGRPVYTSQWDARVDNNMAHIDLSREADAI 88
Cdd:TIGR02113   1 KKILLAVTGSIAAYKAADLTSQLTKLGYDVTVLMTQAATQFITPLTLQVLSKNPVHLDVMDEHDPKVINHIELAKKADLF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500215625   89 VIAPASTDFLAKLAHGFADDLLSTLCVA--RDCPLLVVPAMNRQMWQNPATQRNAAQLRADGVSVLGPDSGAQACGEVGD 166
Cdd:TIGR02113  81 LVAPASANTIAHLAHGFADNIVTSVALAlpPETPKLIAPAMNTKMYQNPITQRNIKILKKIGYQEIQPKESLLACGDYGR 160

                         170
                  ....*....|...
gi 500215625  167 GRMLEPEAIYEAI 179
Cdd:TIGR02113 161 GALADLDDILQTI 173
Flavoprotein pfam02441
Flavoprotein; This family contains diverse flavoprotein enzymes. This family includes ...
 9-183 1.45e-43

Flavoprotein; This family contains diverse flavoprotein enzymes. This family includes epidermin biosynthesis protein, EpiD, which has been shown to be a flavoprotein that binds FMN. This enzyme catalyzes the removal of two reducing equivalents from the cysteine residue of the C-terminal meso-lanthionine of epidermin to form a --C==C-- double bond. This family also includes the B chain of dipicolinate synthase a small polar molecule that accumulates to high concentrations in bacterial endospores, and is thought to play a role in spore heat resistance, or the maintenance of heat resistance. dipicolinate synthase catalyzes the formation of dipicolinic acid from dihydroxydipicolinic acid. This family also includes phenyl-acrylic acid decarboxylase (EC:4.1.1.-).


Pssm-ID: 426775 [Multi-domain]  Cd Length: 177  Bit Score: 149.83  E-value: 1.45e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500215625    9 KHLVLGLTGGIACYKIAELTRLLTKAGATVQVVMTEAAAQFITPVTMQALSGRPVYTSQWDaRVDNNMAHIDL---SREA 85
Cdd:pfam02441   1 KRILVGITGSSAAIKALRLLEELKKEGAEVRVIMTKAAKKVITPETLAALSENVDEDLTWR-ELDDDILHIELasgARWA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500215625   86 DAIVIAPASTDFLAKLAHGFADDLLS----------------TLCVARDCPLLVVPAMNRQMWQNPATQRNAAQLRADGv 149
Cdd:pfam02441  80 DAMVIAPASANTLAKIANGIADNLLTraadvalkerrphlenMLTLTAKKPIIIAPAMNTAMYENPATLENLEDLKADG- 158

                         170       180       190
                  ....*....|....*....|....*....|....
gi 500215625  150 svlgpdsgaqacgevGDGRMLEPEAIYEAIVAHF 183
Cdd:pfam02441 159 ---------------GKGRMPEPEAIVGKVLDAL 177
PLN02496 PLN02496
probable phosphopantothenoylcysteine decarboxylase
 11-179 6.80e-27

probable phosphopantothenoylcysteine decarboxylase


Pssm-ID: 215274  Cd Length: 209  Bit Score: 106.59  E-value: 6.80e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500215625  11 LVLGLTGGIACYKIAELTRLLTKaGATVQVVMTEAAAQFITPVTM-QALSgrpVYT-----SQWDaRVDNNMAHIDLSRE 84
Cdd:PLN02496  22 ILLAASGSVAAIKFGNLCHCFSE-WAEVRAVVTKASLHFIDRASLpKDVT---LYTdedewSSWN-KIGDSVLHIELRRW 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500215625  85 ADAIVIAPASTDFLAKLAHGFADDLLSTLCVARDC--PLLVVPAMNRQMWQNPATQRNAAQLRADGVSVLGPDSGAQACG 162
Cdd:PLN02496  97 ADVMVIAPLSANTLGKIAGGLCDNLLTCIVRAWDYskPLFVAPAMNTFMWNNPFTERHLMSIDELGISLIPPVTKRLACG 176

                        170
                 ....*....|....*..
gi 500215625 163 EVGDGRMLEPEAIYEAI 179
Cdd:PLN02496 177 DYGNGAMAEPSLIYSTV 193
PRK06732 PRK06732
phosphopantothenate--cysteine ligase; Validated
 193-285 2.97e-10

phosphopantothenate--cysteine ligase; Validated


Pssm-ID: 235856 [Multi-domain]  Cd Length: 229  Bit Score: 60.00  E-value: 2.97e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500215625 193 VLITAGPTFEPLDPVRGLTNRSSGKMGFALARAAQQAGADVHLVAGPVAL---DTPWGVYRQdVQTAQQMYDAVMHAVSD 269
Cdd:PRK06732   3 ILITSGGTTEPIDSVRGITNHSTGQLGKIIAETFLAAGHEVTLVTTKTAVkpePHPNLSIIE-IENVDDLLETLEPLVKD 81

                         90
                 ....*....|....*.
gi 500215625 270 ADIFIAVAAVADWRVE 285
Cdd:PRK06732  82 HDVLIHSMAVSDYTPV 97
PRK09620 PRK09620
hypothetical protein; Provisional
 191-331 5.64e-09

hypothetical protein; Provisional


Pssm-ID: 181997  Cd Length: 229  Bit Score: 56.05  E-value: 5.64e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500215625 191 RRVLITAGPTFEPLDPVRGLTNRSSGKMGFALARAAQQAGADVHLVAGPVAlDTPWGVYRQ----------DVQtaQQMY 260
Cdd:PRK09620   4 KKVLITSGGCLEKWDQVRGHTNMAKGTIGRIIAEELISKGAHVIYLHGYFA-EKPNDINNQlelhpfegiiDLQ--DKMK 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 500215625 261 DAVMHavSDADIFIAVAAVADWRVEQPAEHKMK------KTADRKMPALTFVENPDILASVAALPDPPYCVGFAAES 331
Cdd:PRK09620  81 SIITH--EKVDAVIMAAAGSDWVVDKICDQEGNvldmngKISSDIAPIIHFQKAPKVLKQIKQWDPETVLVGFKLES 155
PRK05920 PRK05920
aromatic acid decarboxylase; Validated
 9-111 3.06e-04

aromatic acid decarboxylase; Validated


Pssm-ID: 180312  Cd Length: 204  Bit Score: 41.76  E-value: 3.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500215625   9 KHLVLGLTG--GiACYKIaELTRLLTKAGATVQVVMTEAAAQFI---TPVTMQALSGRPVYtsQWDARVDNNMAHI---- 79
Cdd:PRK05920   4 KRIVLAITGasG-AIYGV-RLLECLLAADYEVHLVISKAAQKVLateTGLKLPAVPDLAEA--FLREQLGAAAGQLrvhg 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 500215625  80 --DL-------SREADAIVIAPASTDFLAKLAHGFADDLLS 111
Cdd:PRK05920  80 kdDWgapiasgSFRTDGMVIAPCSMGTLAAIAHGLSDNLIE 120
PRK06029 PRK06029
UbiX family flavin prenyltransferase;
9-111 1.44e-03

UbiX family flavin prenyltransferase;


Pssm-ID: 235677  Cd Length: 185  Bit Score: 39.50  E-value: 1.44e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500215625   9 KHLVLGLTGGI-ACYKIAELTRLLTKAGATVQVVMTEAAAQFI---TPVTMQALSGRpvytsqwdARVDNNMAHIDL--- 81
Cdd:PRK06029   2 KRLIVGISGASgAIYGVRLLQVLRDVGEIETHLVISQAARQTLaheTDFSLRDVQAL--------ADVVHDVRDIGAsia 73

                         90       100       110
                 ....*....|....*....|....*....|..
gi 500215625  82 --SREADAIVIAPASTDFLAKLAHGFADDLLS 111
Cdd:PRK06029  74 sgSFGTDGMVIAPCSMKTLAKIAHGYSDNLIT 105
spoVFB PRK08305
dipicolinate synthase subunit B; Reviewed
 5-107 3.29e-03

dipicolinate synthase subunit B; Reviewed


Pssm-ID: 181370 [Multi-domain]  Cd Length: 196  Bit Score: 38.34  E-value: 3.29e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500215625   5 ELAGKHLVLGLTGGIACYK--IAELTRLLtKAGATVQVVMTEAAAQFITPV--------TMQALSGRPVYTSQWDARvdn 74
Cdd:PRK08305   2 SLKGKRIGFGLTGSHCTYDevMPEIEKLV-DEGAEVTPIVSYTVQTTDTRFgkaeewikKIEEITGNKVINTIVEAE--- 77

                         90       100       110
                 ....*....|....*....|....*....|...
gi 500215625  75 nmaHIDLSREADAIVIAPASTDFLAKLAHGFAD 107
Cdd:PRK08305  78 ---PLGPKKLLDCMVIAPCTGNTMAKLANAITD 107
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH