NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|500267327|ref|WP_011918211|]
View 

sugar ABC transporter permease [Caldicellulosiruptor saccharolyticus]

Protein Classification

ABC transporter permease( domain architecture ID 10008345)

ABC transporter permease is the transmembrane subunit found in a periplasmic binding protein (PBP)-dependent ABC transport system, which may be involved in the transport of one or more from a variety of substrates including sugars, ions, amino acids, and peptides, among others

Gene Ontology:  GO:0055085|GO:0140359|GO:0042626|GO:0016020
PubMed:  31571164|27273632|26517919|18535149|17723295|25750732|24638992
TCDB:  3.A.1

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
LplB COG4209
ABC-type polysaccharide transport system, permease component [Carbohydrate transport and ...
 2-304 6.38e-133

ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism];


:

Pssm-ID: 443357 [Multi-domain]  Cd Length: 316  Bit Score: 379.82  E-value: 6.38e-133
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500267327   2 RKKGSVIYELTKNKALYLMTLPGIIFFFIFDYITYIGIIIAFQDFDYSKGIFGSKFVGLRNIRFVIESGDLPRIVFNTLY 81
Cdd:COG4209   14 KRKKSFLKRLKRDWQLYLMLLPGLIYLLIFSYLPMYGIVIAFKDYNPFKGIFGSPWVGLKNFKFLFSSPDFWRVLRNTLL 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500267327  82 LNLLFIFTGLIFSIGIAVLLNEITNPIYRKVSQSVSILPHFLSWTVVAMFLLTLCSPESGLINKVLKSMGLEPINFYGDP 161
Cdd:COG4209   94 ISLLKLVFGFPLPIILALLLNELRSKRFKKTVQTISYLPHFLSWVVVAGIVYQFLSPDTGLVNQLLRALGGEPINFLTEP 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500267327 162 RPWPLLLTILRIWKGAGWGSIIYLATITGIDPELFEAARIDGASRLQCIRYITLPELKQPAILLTLMGLGNIFKGDFGMI 241
Cdd:COG4209  174 KYFRPIYVFSGIWKEAGWGSIIYLAAITGIDPELYEAAAIDGAGRWQQIWHITLPGIRPTIVILLILNIGNILNVGFEQI 253

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 500267327 242 YALvgDNSLLFPTTDVIDTYVFRALRQLNDVGMSAAVGLMQSIVGFILVVIVNTLVKRIDEEA 304
Cdd:COG4209  254 YLL--YNPLNYSTSDVIDTYVYRIGLQNGDYSYATAVGLFKSVVGLILVLIANKIAKKLGEES 314
 
Name Accession Description Interval E-value
LplB COG4209
ABC-type polysaccharide transport system, permease component [Carbohydrate transport and ...
 2-304 6.38e-133

ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 443357 [Multi-domain]  Cd Length: 316  Bit Score: 379.82  E-value: 6.38e-133
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500267327   2 RKKGSVIYELTKNKALYLMTLPGIIFFFIFDYITYIGIIIAFQDFDYSKGIFGSKFVGLRNIRFVIESGDLPRIVFNTLY 81
Cdd:COG4209   14 KRKKSFLKRLKRDWQLYLMLLPGLIYLLIFSYLPMYGIVIAFKDYNPFKGIFGSPWVGLKNFKFLFSSPDFWRVLRNTLL 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500267327  82 LNLLFIFTGLIFSIGIAVLLNEITNPIYRKVSQSVSILPHFLSWTVVAMFLLTLCSPESGLINKVLKSMGLEPINFYGDP 161
Cdd:COG4209   94 ISLLKLVFGFPLPIILALLLNELRSKRFKKTVQTISYLPHFLSWVVVAGIVYQFLSPDTGLVNQLLRALGGEPINFLTEP 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500267327 162 RPWPLLLTILRIWKGAGWGSIIYLATITGIDPELFEAARIDGASRLQCIRYITLPELKQPAILLTLMGLGNIFKGDFGMI 241
Cdd:COG4209  174 KYFRPIYVFSGIWKEAGWGSIIYLAAITGIDPELYEAAAIDGAGRWQQIWHITLPGIRPTIVILLILNIGNILNVGFEQI 253

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 500267327 242 YALvgDNSLLFPTTDVIDTYVFRALRQLNDVGMSAAVGLMQSIVGFILVVIVNTLVKRIDEEA 304
Cdd:COG4209  254 YLL--YNPLNYSTSDVIDTYVYRIGLQNGDYSYATAVGLFKSVVGLILVLIANKIAKKLGEES 314
PRK10561 PRK10561
sn-glycerol-3-phosphate ABC transporter permease UgpA;
53-298 2.04e-09

sn-glycerol-3-phosphate ABC transporter permease UgpA;


Pssm-ID: 182550 [Multi-domain]  Cd Length: 280  Bit Score: 57.53  E-value: 2.04e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500267327  53 FGSKFVGLRNIRFVIESGDLPRIVFNTLYLNLLFIFTGLIFSIGIAVLLNEITNpiYRKVSQSVSILPHFLSWTVVAMFL 132
Cdd:PRK10561  34 FSSQFVGLDNFVALFHDSYYLDSFWTTIKFSTLVTVSGLLVSLFFAALVDYVVR--GSRFYQTLMLLPYAVAPAVAAVLW 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500267327 133 LTLCSPESGLINKVLKSMGLEpINFYGDPRPWPLLLTILRIWKGAGWGSIIYLATITGIDPELFEAARIDGASRLQCIRY 212
Cdd:PRK10561 112 IFLFNPGRGLITHFLAEFGYD-WNHAQNSGQAMFLVVFASVWKQISYNFLFFFAALQSIPRSLVEAAAIDGAGPIRRFFK 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500267327 213 ITLPELKQPAILLTLMGLGNIFKGDFGMIYALVGDNSLLFPTTDVIDTYV--FRALrqlnDVGMSAAvglmQSIVgFILV 290
Cdd:PRK10561 191 LALPLIAPVSFFLLVVNLVYAFFDTFPVIDAATSGGPVQATTTLIYKIYRegFTGL----DLSSSAA----QSVV-LMFL 261


                 ....*...
gi 500267327 291 VIVNTLVK 298
Cdd:PRK10561 262 VIVLTVVQ 269
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 77-287 7.08e-07

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 48.81  E-value: 7.08e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500267327  77 FNTLYLNLLFIFTGLIFSIGIAVLLNEITNPIyRKVSQSVSILPHFLSWTVVAMFLLTLCSPesglinkvlksmgLEPIN 156
Cdd:cd06261    2 LNTLLLALIATLLALVLGLLLGIILARKRGKL-DRLLRRIIDLLLSLPSLVLGLLLVLLFGV-------------LLGWG 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500267327 157 FYGDPRPWPLLLTILRIwkgAGWGSIIYLATITGIDPELFEAARIDGASRLQCIRYITLPELKQPAILLTLMGLGNIFkG 236
Cdd:cd06261   68 ILPGLGLPALILALLLI---APFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARAL-G 143

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 500267327 237 DFGMIYALVGDNSLLFPTTdvidTYVFRALRQLNDVGMSAAVGLMQSIVGF 287
Cdd:cd06261  144 EFALVSFLGGGEAPGPGTG----LLLIFAILFPGDLGVAAAVALILLLLSL 190
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 150-300 4.81e-06

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 46.14  E-value: 4.81e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500267327  150 MGLEPINFYGDPRPWPLLLTILRIWKGAGWGSIIYLATITGIDPELFEAARIDGASRLQCIRYITLPELKQPAILLTLMG 229
Cdd:pfam00528  37 ILLVVIAILSILGHGILPAIILALLGWAGYARLIRRAALRSLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALA 116

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 500267327  230 LGNIFKGdFGMIYALVGDNSLLFPTTDVIDTYVFRALrqlndVGMSAAVGLMQSIVGFILVVIVNTLVKRI 300
Cdd:pfam00528 117 FGGALGG-AVLLEFLGSWPGLGLLLIEAILGYDYPEI-----QGPVLAAALILLLLNLLVDILQRLLDPRV 181
 
Name Accession Description Interval E-value
LplB COG4209
ABC-type polysaccharide transport system, permease component [Carbohydrate transport and ...
 2-304 6.38e-133

ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 443357 [Multi-domain]  Cd Length: 316  Bit Score: 379.82  E-value: 6.38e-133
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500267327   2 RKKGSVIYELTKNKALYLMTLPGIIFFFIFDYITYIGIIIAFQDFDYSKGIFGSKFVGLRNIRFVIESGDLPRIVFNTLY 81
Cdd:COG4209   14 KRKKSFLKRLKRDWQLYLMLLPGLIYLLIFSYLPMYGIVIAFKDYNPFKGIFGSPWVGLKNFKFLFSSPDFWRVLRNTLL 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500267327  82 LNLLFIFTGLIFSIGIAVLLNEITNPIYRKVSQSVSILPHFLSWTVVAMFLLTLCSPESGLINKVLKSMGLEPINFYGDP 161
Cdd:COG4209   94 ISLLKLVFGFPLPIILALLLNELRSKRFKKTVQTISYLPHFLSWVVVAGIVYQFLSPDTGLVNQLLRALGGEPINFLTEP 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500267327 162 RPWPLLLTILRIWKGAGWGSIIYLATITGIDPELFEAARIDGASRLQCIRYITLPELKQPAILLTLMGLGNIFKGDFGMI 241
Cdd:COG4209  174 KYFRPIYVFSGIWKEAGWGSIIYLAAITGIDPELYEAAAIDGAGRWQQIWHITLPGIRPTIVILLILNIGNILNVGFEQI 253

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 500267327 242 YALvgDNSLLFPTTDVIDTYVFRALRQLNDVGMSAAVGLMQSIVGFILVVIVNTLVKRIDEEA 304
Cdd:COG4209  254 YLL--YNPLNYSTSDVIDTYVYRIGLQNGDYSYATAVGLFKSVVGLILVLIANKIAKKLGEES 314
UgpA COG1175
ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];
38-299 3.80e-43

ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440788 [Multi-domain]  Cd Length: 298  Bit Score: 149.90  E-value: 3.80e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500267327  38 GIIIAFQDFDYSKgiFGSKFVGLRNIRFVIESGDLPRIVFNTLYLNLLFIFTGLIFSIGIAVLLNEitNPIYRKVSQSVS 117
Cdd:COG1175   42 TLYLSFTDWNLLG--PPPEFVGLDNYARLFTDPRFWNALGNTLLFTVVSVPLQLVLGLLLALLLNR--KLRGRGFFRTLF 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500267327 118 ILPHFLSWTVVAMFLLTLCSPESGLINKVLKSMGLEPINFYGDPRPWPLLLTILRIWKGAGWGSIIYLATITGIDPELFE 197
Cdd:COG1175  118 FLPWVISPVVVALIWKWLFNPDYGLLNALLGALGLEPINWLGDPSLALPAVIIVTVWKGTGFNMLIFLAGLQSIPRELYE 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500267327 198 AARIDGASRLQCIRYITLPELKQPAILLTLMGLGNIFKgDFGMIYALVG---DNSllfptTDVIDTYVFRALRQLNDVGM 274
Cdd:COG1175  198 AARIDGASPWQRFRRITLPLLRPTILFVLVLSTIGALQ-VFDLVYVLTGggpGNS-----TTTLVLYIYQTAFQQFDFGY 271

                        250       260
                 ....*....|....*....|....*
gi 500267327 275 SAAVGLMQSIVGFILVVIVNTLVKR 299
Cdd:COG1175  272 ASAIAVVLFLIILVLTLLQLRLLRR 296
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
57-299 6.43e-12

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 65.95  E-value: 6.43e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500267327  57 FVGLRNIRFVIESGDLPRIVFNTLYLNLLFIFTGLIFSIGIAVLLnEITNPIYRKVSQSVSILPHFLSWTVVAMFLLTLC 136
Cdd:COG1178   37 TDGLANFWALLSDPYLWRALGNTLLLALLVTLLSLLLGVPLAWLL-ARTDFPGRRLLRWLLLLPLALPPYVVALAWIALF 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500267327 137 SPeSGLINKVLKSM-GLEPINFYGdprPWPLLLTIlriwkGAGWGSIIYLATITG---IDPELFEAARIDGASRLQCIRY 212
Cdd:COG1178  116 GP-NGLLNTLLRALfGLEPPDIYG---LGGIILVL-----VLFNYPYVYLLLRAAlrsIDASLEEAARSLGASPWRAFRR 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500267327 213 ITLPELKqPAIL--LTLMGLGNIfkGDFGmIYALVGDNsllfptTDVIDTYVFRALRQLNDVGMSAAVGLMQSIVGFILV 290
Cdd:COG1178  187 VTLPLLR-PAIAagALLVFLLCL--ADFG-TPLVLGGG------YTTLTTAIYQAWLGDFDLGAAAALALVLLLLVLLLL 256


                 ....*....
gi 500267327 291 VIVNTLVKR 299
Cdd:COG1178  257 LLERRLRRR 265
PRK10561 PRK10561
sn-glycerol-3-phosphate ABC transporter permease UgpA;
53-298 2.04e-09

sn-glycerol-3-phosphate ABC transporter permease UgpA;


Pssm-ID: 182550 [Multi-domain]  Cd Length: 280  Bit Score: 57.53  E-value: 2.04e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500267327  53 FGSKFVGLRNIRFVIESGDLPRIVFNTLYLNLLFIFTGLIFSIGIAVLLNEITNpiYRKVSQSVSILPHFLSWTVVAMFL 132
Cdd:PRK10561  34 FSSQFVGLDNFVALFHDSYYLDSFWTTIKFSTLVTVSGLLVSLFFAALVDYVVR--GSRFYQTLMLLPYAVAPAVAAVLW 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500267327 133 LTLCSPESGLINKVLKSMGLEpINFYGDPRPWPLLLTILRIWKGAGWGSIIYLATITGIDPELFEAARIDGASRLQCIRY 212
Cdd:PRK10561 112 IFLFNPGRGLITHFLAEFGYD-WNHAQNSGQAMFLVVFASVWKQISYNFLFFFAALQSIPRSLVEAAAIDGAGPIRRFFK 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500267327 213 ITLPELKQPAILLTLMGLGNIFKGDFGMIYALVGDNSLLFPTTDVIDTYV--FRALrqlnDVGMSAAvglmQSIVgFILV 290
Cdd:PRK10561 191 LALPLIAPVSFFLLVVNLVYAFFDTFPVIDAATSGGPVQATTTLIYKIYRegFTGL----DLSSSAA----QSVV-LMFL 261


                 ....*...
gi 500267327 291 VIVNTLVK 298
Cdd:PRK10561 262 VIVLTVVQ 269
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 77-287 7.08e-07

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 48.81  E-value: 7.08e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500267327  77 FNTLYLNLLFIFTGLIFSIGIAVLLNEITNPIyRKVSQSVSILPHFLSWTVVAMFLLTLCSPesglinkvlksmgLEPIN 156
Cdd:cd06261    2 LNTLLLALIATLLALVLGLLLGIILARKRGKL-DRLLRRIIDLLLSLPSLVLGLLLVLLFGV-------------LLGWG 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500267327 157 FYGDPRPWPLLLTILRIwkgAGWGSIIYLATITGIDPELFEAARIDGASRLQCIRYITLPELKQPAILLTLMGLGNIFkG 236
Cdd:cd06261   68 ILPGLGLPALILALLLI---APFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARAL-G 143

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 500267327 237 DFGMIYALVGDNSLLFPTTdvidTYVFRALRQLNDVGMSAAVGLMQSIVGF 287
Cdd:cd06261  144 EFALVSFLGGGEAPGPGTG----LLLIFAILFPGDLGVAAAVALILLLLSL 190
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
60-299 2.97e-06

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 48.62  E-value: 2.97e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500267327  60 LRNIRFVIESGDLPRIVFNTLYLNLLFIFTGLIFSIGIAVLLNEITNPIyRKVSQSVSILPHFLSWTVVAM-FLLTLcsp 138
Cdd:COG1178  324 LDNYRFVLLDPSLLRALLNSLLLALLAALLAVLLALLLAYLVRRRRGRL-ARLLDRLAMLPYAVPGIVLGLgLLLLF--- 399

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500267327 139 esglinkvlksMGLEPINFYGdprPWPLLL---TILRIwkgaGWGSIIYLATITGIDPELFEAARIDGASRLQCIRYITL 215
Cdd:COG1178  400 -----------NRPLPLLLYG---TLAILVlayVVRFL----PFALRSLEAALAQIDPSLEEAARSLGASPLRTLRRVTL 461

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500267327 216 PELKqPAILLTLMGLGNIFKGDFGMIYALVGdnsllfPTTDVIDTYVFRALRQlNDVGMSAAVGLMQSIVGFILVVIVNT 295
Cdd:COG1178  462 PLLR-PGLLAAALLVFVTSMKELSATLLLRP------PGFETLAVLIYQLASS-GRYGEAAALALLLVLVSLLPVLLLER 533


                 ....
gi 500267327 296 LVKR 299
Cdd:COG1178  534 LLGR 537
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 150-300 4.81e-06

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 46.14  E-value: 4.81e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500267327  150 MGLEPINFYGDPRPWPLLLTILRIWKGAGWGSIIYLATITGIDPELFEAARIDGASRLQCIRYITLPELKQPAILLTLMG 229
Cdd:pfam00528  37 ILLVVIAILSILGHGILPAIILALLGWAGYARLIRRAALRSLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALA 116

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 500267327  230 LGNIFKGdFGMIYALVGDNSLLFPTTDVIDTYVFRALrqlndVGMSAAVGLMQSIVGFILVVIVNTLVKRI 300
Cdd:pfam00528 117 FGGALGG-AVLLEFLGSWPGLGLLLIEAILGYDYPEI-----QGPVLAAALILLLLNLLVDILQRLLDPRV 181
CysU COG0555
ABC-type sulfate transport system, permease component [Inorganic ion transport and metabolism]; ...
 186-299 1.80e-05

ABC-type sulfate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440321 [Multi-domain]  Cd Length: 268  Bit Score: 45.51  E-value: 1.80e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500267327 186 ATITGIDPELFEAARIDGASRLQCIRYITLPELKqPAIlltLMGLGNIFK---GDFGMIYALVGdnSLLFpTTDVIDTYV 262
Cdd:COG0555  157 PVLEELDPELEEAAATLGASRWQTFRRVILPLLL-PAL---LTGFALAFAralGEFGAVIFIAG--NLPM-KTEILPLLI 229

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 500267327 263 FRALRQLnDVGMSAAVGLMQSIVGFILVVIVNTLVKR 299
Cdd:COG0555  230 YLKLEEG-DYAGATAIALVLLLISFLLLLLINLLQRR 265
PotB COG1176
ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport ...
 37-305 1.92e-05

ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism];


Pssm-ID: 440789 [Multi-domain]  Cd Length: 287  Bit Score: 45.52  E-value: 1.92e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500267327  37 IGIIIAFQDFDYSKGIFGSkfVGLRNIRFVIESGDLPRIVFNTLYLNLLFIFTGLIFSIGIAVLLNeITNPIYRKVSQSV 116
Cdd:COG1176   32 LLLVYSFTTRDPYGGVVPG--FTLENYARLFTDPLYLKVLLRTLWIALLTTLICLLLGYPIAYFLA-RAPPRWRNLLLLL 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500267327 117 SILPHFLSWTVVAMFLLTLCSPEsGLINKVLKSMGLepinfygDPRPWPLLLTILRIWKGAGWGSI------IYlATITG 190
Cdd:COG1176  109 VILPFWTSFLVRTYAWIVLLGRN-GLLNSLLLALGL-------IDEPLRLLYTEFAVVIGLVYVYLpfmvlpLY-AALEK 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500267327 191 IDPELFEAARIDGASRLQCIRYITLPELKqPAIL--------LTLmglgnifkGDFGMIYALVGDNSLLFPTtdVIDTYV 262
Cdd:COG1176  180 IDPSLLEAARDLGASPWQTFRRVILPLSL-PGIIagsllvfiPAL--------GAFVTPALLGGGKVLMIGN--LIYQQF 248

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 500267327 263 FralrQLNDVGMSAAVGLMQSIVGFILVVIVNTLVKRIDEEAA 305
Cdd:COG1176  249 L----SALNWPLAAALAVVLLLIVLLVLLLYLRLLRRRRLLGG 287
PotC COG1177
ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport ...
 185-299 2.38e-05

ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism];


Pssm-ID: 440790 [Multi-domain]  Cd Length: 262  Bit Score: 45.10  E-value: 2.38e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500267327 185 LATITGIDPELFEAARIDGASRLQCIRYITLPELKqPAILL-TLMGLGNIFkGDFGMIYALVGDNSLLFPttdvidTYVF 263
Cdd:COG1177  151 LARLQGFDPSLEEAARDLGASPWQTFRRVTLPLIA-PGILAgALLAFTLSF-DEFVITLFLAGPGVTTLP------VYIY 222

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 500267327 264 RALRQLNDvGMSAAVGLMQSIVGFILVVIVNTLVKR 299
Cdd:COG1177  223 SMIRRGIS-PEINALSTLLILLSLLLLLLAERLRRR 257
UgpE COG0395
ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and ...
 188-223 2.44e-03

ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440164 [Multi-domain]  Cd Length: 282  Bit Score: 38.92  E-value: 2.44e-03
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 500267327 188 ITGIDPELFEAARIDGASRLQCIRYITLPELKqPAI 223
Cdd:COG0395  167 FRSIPRELEEAARIDGASEFRIFWRIVLPLSK-PAL 201
MalG COG3833
ABC-type maltose transport system, permease component MalG [Carbohydrate transport and ...
 191-229 3.22e-03

ABC-type maltose transport system, permease component MalG [Carbohydrate transport and metabolism];


Pssm-ID: 443045 [Multi-domain]  Cd Length: 282  Bit Score: 38.59  E-value: 3.22e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 500267327 191 IDPELFEAARIDGASRLQCIRYITLPeLKQPAI----LLTLMG 229
Cdd:COG3833  169 IPKELDEAAKIDGASHFQIFFRIILP-LAKPILavvaLLSFIG 210
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH