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Conserved domains on  [gi|500492129|ref|WP_011946314|]
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MarR family winged helix-turn-helix transcriptional regulator [Legionella pneumophila]

Protein Classification

MarR family winged helix-turn-helix transcriptional regulator( domain architecture ID 11448790)

MarR family winged helix-turn-helix (wHTH) transcriptional regulator similar to Bacillus thuringiensis DNA-binding transcriptional repressor TubR, a DNA-binding protein that is part of the type III plasmid partition system used to ensure correct segregation of the pBtoxis plasmid

Gene Ontology:  GO:0006355|GO:0003700
PubMed:  10498949|28670937
SCOP:  4000246

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
3-133 5.59e-28

DNA-binding transcriptional regulator, MarR family [Transcription];


:

Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 100.43  E-value: 5.59e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500492129   3 LSSLLKKTNRLLIKRANELIKPYAMSHAYTYILMELYIEDGLTQSELVQLIEVEQPTLVRTLDRMERDGFITRKPSSMDR 82
Cdd:COG1846   12 LGLLLRRLARALRRALDRALAELGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPDPEDR 91

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 500492129  83 RAVHIFLTEKARLLQEKIDECSRILNDEILAGFSEDEKTKLQELTHRVLDN 133
Cdd:COG1846   92 RAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLRRLAEN 142
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
3-133 5.59e-28

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 100.43  E-value: 5.59e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500492129   3 LSSLLKKTNRLLIKRANELIKPYAMSHAYTYILMELYIEDGLTQSELVQLIEVEQPTLVRTLDRMERDGFITRKPSSMDR 82
Cdd:COG1846   12 LGLLLRRLARALRRALDRALAELGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPDPEDR 91

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 500492129  83 RAVHIFLTEKARLLQEKIDECSRILNDEILAGFSEDEKTKLQELTHRVLDN 133
Cdd:COG1846   92 RAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLRRLAEN 142
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
23-120 3.38e-19

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 76.48  E-value: 3.38e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500492129    23 KPYAMSHAYTYILMELYIEDGLTQSELVQLIEVEQPTLVRTLDRMERDGFITRKPSSMDRRAVHIFLTEKARLLQEKIDE 102
Cdd:smart00347   4 KPLGLTPTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIEQLLE 83

                           90
                   ....*....|....*...
gi 500492129   103 CSRILNDEILAGFSEDEK 120
Cdd:smart00347  84 ARSETLAELLAGLTAEEQ 101
PRK03573 PRK03573
transcriptional regulator SlyA; Provisional
 42-133 1.85e-17

transcriptional regulator SlyA; Provisional


Pssm-ID: 179596  Cd Length: 144  Bit Score: 73.50  E-value: 1.85e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500492129  42 DGLTQSELVQLIEVEQPTLVRTLDRMERDGFITRKPSSMDRRAVHIFLTEKARLLQEKIDECSRILNDEILAGFSEDEKT 121
Cdd:PRK03573  45 PEQSQIQLAKAIGIEQPSLVRTLDQLEEKGLISRQTCASDRRAKRIKLTEKAEPLISEVEAVINKTRAEILHGISAEEIE 124

                         90
                 ....*....|..
gi 500492129 122 KLQELTHRVLDN 133
Cdd:PRK03573 125 QLITLIAKLEKN 136
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 27-84 3.35e-12

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 57.60  E-value: 3.35e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 500492129   27 MSHAYTYILMELYIEDGLTQSELVQLIEVEQPTLVRTLDRMERDGFITRKPSSMDRRA 84
Cdd:pfam12802   3 LTPAQFRVLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPADRRA 60
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 34-98 7.21e-03

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 33.43  E-value: 7.21e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 500492129  34 ILMELYiEDGLTQSELVQLIEVEQPTLVRTLDRMERDGFITRKPssmDRRAVHIFLTEKARLLQE 98
Cdd:cd00090   12 ILRLLL-EGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRR---EGRRVYYSLTDAERLLAL 72
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
3-133 5.59e-28

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 100.43  E-value: 5.59e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500492129   3 LSSLLKKTNRLLIKRANELIKPYAMSHAYTYILMELYIEDGLTQSELVQLIEVEQPTLVRTLDRMERDGFITRKPSSMDR 82
Cdd:COG1846   12 LGLLLRRLARALRRALDRALAELGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPDPEDR 91

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 500492129  83 RAVHIFLTEKARLLQEKIDECSRILNDEILAGFSEDEKTKLQELTHRVLDN 133
Cdd:COG1846   92 RAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLRRLAEN 142
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
23-120 3.38e-19

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 76.48  E-value: 3.38e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500492129    23 KPYAMSHAYTYILMELYIEDGLTQSELVQLIEVEQPTLVRTLDRMERDGFITRKPSSMDRRAVHIFLTEKARLLQEKIDE 102
Cdd:smart00347   4 KPLGLTPTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIEQLLE 83

                           90
                   ....*....|....*...
gi 500492129   103 CSRILNDEILAGFSEDEK 120
Cdd:smart00347  84 ARSETLAELLAGLTAEEQ 101
PRK03573 PRK03573
transcriptional regulator SlyA; Provisional
 42-133 1.85e-17

transcriptional regulator SlyA; Provisional


Pssm-ID: 179596  Cd Length: 144  Bit Score: 73.50  E-value: 1.85e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500492129  42 DGLTQSELVQLIEVEQPTLVRTLDRMERDGFITRKPSSMDRRAVHIFLTEKARLLQEKIDECSRILNDEILAGFSEDEKT 121
Cdd:PRK03573  45 PEQSQIQLAKAIGIEQPSLVRTLDQLEEKGLISRQTCASDRRAKRIKLTEKAEPLISEVEAVINKTRAEILHGISAEEIE 124

                         90
                 ....*....|..
gi 500492129 122 KLQELTHRVLDN 133
Cdd:PRK03573 125 QLITLIAKLEKN 136
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 27-84 3.35e-12

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 57.60  E-value: 3.35e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 500492129   27 MSHAYTYILMELYIEDGLTQSELVQLIEVEQPTLVRTLDRMERDGFITRKPSSMDRRA 84
Cdd:pfam12802   3 LTPAQFRVLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPADRRA 60
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 34-85 8.47e-10

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 51.39  E-value: 8.47e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 500492129   34 ILMELYIEDGLTQSELVQLIEVEQPTLVRTLDRMERDGFITRKPSSMDRRAV 85
Cdd:pfam01047   8 ILRILYEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSRSPEDRREV 59
PRK11512 PRK11512
multiple antibiotic resistance transcriptional regulator MarR;
8-131 7.56e-08

multiple antibiotic resistance transcriptional regulator MarR;


Pssm-ID: 183170  Cd Length: 144  Bit Score: 48.36  E-value: 7.56e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500492129   8 KKTNRLLikraNELIKPYAMSHAYTYILMELYIEDGLTQSELVQLIEVEQPTLVRTLDRMERDGFITRKPSSMDRRAVHI 87
Cdd:PRK11512  23 QKKDRLL----NEYLSPLDITAAQFKVLCSIRCAACITPVELKKVLSVDLGALTRMLDRLVCKGWVERLPNPNDKRGVLV 98

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 500492129  88 FLTEKARLLQEKIDE-CSRILNDEILAGFSEDEKTKLQELTHRVL 131
Cdd:PRK11512  99 KLTTSGAAICEQCHQlVGQDLHQELTKNLTADEVATLEHLLKKVL 143
PRK10870 PRK10870
transcriptional repressor MprA; Provisional
 62-134 6.01e-05

transcriptional repressor MprA; Provisional


Pssm-ID: 182795  Cd Length: 176  Bit Score: 40.89  E-value: 6.01e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 500492129  62 RTLDRMERDGFITRKPSSMDRRAVHIFLTEKAR-LLQEKIDECSRILNdEILAGFSEDEKTKLQELTHRVLDNL 134
Cdd:PRK10870  90 RIADELEKRGWIERRESDNDRRCLHLQLTEKGHeFLREVLPPQHNCLH-QLWSALSTTEKDQLEQITRKLLSRL 162
PRK11050 PRK11050
manganese-binding transcriptional regulator MntR;
46-118 8.81e-05

manganese-binding transcriptional regulator MntR;


Pssm-ID: 182927 [Multi-domain]  Cd Length: 152  Bit Score: 39.99  E-value: 8.81e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 500492129  46 QSELVQLIEVEQPTLVRTLDRMERDGFITRKPSsmdrRAVhiFLTEKARLLQEKIDECSRILNDEILA-GFSED 118
Cdd:PRK11050  54 QVDIAARLGVSQPTVAKMLKRLARDGLVEMRPY----RGV--FLTPEGEKLAQESRERHQIVENFLLAlGVSPE 121
HTH_27 pfam13463
Winged helix DNA-binding domain;
41-93 3.68e-04

Winged helix DNA-binding domain;


Pssm-ID: 433228 [Multi-domain]  Cd Length: 68  Bit Score: 36.88  E-value: 3.68e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 500492129   41 EDGLTQSELVQLIEVEQPTLVRTLDRMERDGFITRKPSSMDRRAVHIFLTEKA 93
Cdd:pfam13463  16 GDPKTLADICFRLNVEDSHVSYSLKKLTEAGLVEREGSEEDGRETRVRLTAKG 68
HxlR COG1733
DNA-binding transcriptional regulator, HxlR family [Transcription];
47-102 1.35e-03

DNA-binding transcriptional regulator, HxlR family [Transcription];


Pssm-ID: 441339  Cd Length: 108  Bit Score: 36.00  E-value: 1.35e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 500492129  47 SELVQLIE-VEQPTLVRTLDRMERDGFITRKPSSMDRRAVHIFLTEKARLLQEKIDE 102
Cdd:COG1733   39 GELRRSLPgISQKMLTQRLRELEEDGLVERTVYPEVPPRVEYSLTEKGRSLLPVLDA 95
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 34-98 7.21e-03

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 33.43  E-value: 7.21e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 500492129  34 ILMELYiEDGLTQSELVQLIEVEQPTLVRTLDRMERDGFITRKPssmDRRAVHIFLTEKARLLQE 98
Cdd:cd00090   12 ILRLLL-EGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRR---EGRRVYYSLTDAERLLAL 72
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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