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Conserved domains on  [gi|500691617|ref|WP_011976085|]
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metal-dependent hydrolase [Sinorhizobium medicae]

Protein Classification

metal-dependent hydrolase( domain architecture ID 5679)

metal-dependent hydrolase is an inner-membrane YdjM family protein that may act as a phospholipase; similar to Clostridium perfringens membrane-bound metal-dependent hydrolase TcpI

Gene Ontology:  GO:0005886|GO:0016787|GO:0046872

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YdjM super family cl00868
LexA-binding, inner membrane-associated putative hydrolase; YdjM is a family of putative ...
 24-156 9.32e-07

LexA-binding, inner membrane-associated putative hydrolase; YdjM is a family of putative LexA-binding proteins. Members are predicted to be membrane-bound metal-dependent hydrolases that may be acting as phospholipases. It is a member of the SOS network, that rescues cells from UV and other DNA-damage. Expression of YdjM is regulated by LexA.


The actual alignment was detected with superfamily member pfam04307:

Pssm-ID: 469964  Cd Length: 172  Bit Score: 46.27  E-value: 9.32e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500691617   24 WRPALAVGLIFSLAPDLDLFYFYLvdGRRTPH----HDYWTHAPLFWLAAAALTVLALSLAGKRqyLIFVGIAFANVLLH 99
Cdd:pfam04307  26 EAALLAAGALGALLPDIDHPKSKL--GRRLPYlsspHRGFTHSLLFLLLLALLLAALLARFGRR--LPLGLALLLGYLSH 101

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 500691617  100 LFLDSI-AADIRWLYPFSDIRFNLVEIPARYQPWYLNFILHWTFAAEMAICVAAVWAW 156
Cdd:pfam04307 102 LLLDMLtPYGVQLLWPFSDKRIRLGLLFIRIDPLFTLPLLVLGPRRRGGAALALVLLV 159
 
Name Accession Description Interval E-value
YdjM pfam04307
LexA-binding, inner membrane-associated putative hydrolase; YdjM is a family of putative ...
 24-156 9.32e-07

LexA-binding, inner membrane-associated putative hydrolase; YdjM is a family of putative LexA-binding proteins. Members are predicted to be membrane-bound metal-dependent hydrolases that may be acting as phospholipases. It is a member of the SOS network, that rescues cells from UV and other DNA-damage. Expression of YdjM is regulated by LexA.


Pssm-ID: 427854  Cd Length: 172  Bit Score: 46.27  E-value: 9.32e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500691617   24 WRPALAVGLIFSLAPDLDLFYFYLvdGRRTPH----HDYWTHAPLFWLAAAALTVLALSLAGKRqyLIFVGIAFANVLLH 99
Cdd:pfam04307  26 EAALLAAGALGALLPDIDHPKSKL--GRRLPYlsspHRGFTHSLLFLLLLALLLAALLARFGRR--LPLGLALLLGYLSH 101

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 500691617  100 LFLDSI-AADIRWLYPFSDIRFNLVEIPARYQPWYLNFILHWTFAAEMAICVAAVWAW 156
Cdd:pfam04307 102 LLLDMLtPYGVQLLWPFSDKRIRLGLLFIRIDPLFTLPLLVLGPRRRGGAALALVLLV 159
 
Name Accession Description Interval E-value
YdjM pfam04307
LexA-binding, inner membrane-associated putative hydrolase; YdjM is a family of putative ...
 24-156 9.32e-07

LexA-binding, inner membrane-associated putative hydrolase; YdjM is a family of putative LexA-binding proteins. Members are predicted to be membrane-bound metal-dependent hydrolases that may be acting as phospholipases. It is a member of the SOS network, that rescues cells from UV and other DNA-damage. Expression of YdjM is regulated by LexA.


Pssm-ID: 427854  Cd Length: 172  Bit Score: 46.27  E-value: 9.32e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500691617   24 WRPALAVGLIFSLAPDLDLFYFYLvdGRRTPH----HDYWTHAPLFWLAAAALTVLALSLAGKRqyLIFVGIAFANVLLH 99
Cdd:pfam04307  26 EAALLAAGALGALLPDIDHPKSKL--GRRLPYlsspHRGFTHSLLFLLLLALLLAALLARFGRR--LPLGLALLLGYLSH 101

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 500691617  100 LFLDSI-AADIRWLYPFSDIRFNLVEIPARYQPWYLNFILHWTFAAEMAICVAAVWAW 156
Cdd:pfam04307 102 LLLDMLtPYGVQLLWPFSDKRIRLGLLFIRIDPLFTLPLLVLGPRRRGGAALALVLLV 159
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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