NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|500733028|ref|WP_011982327|]
View 

MULTISPECIES: aconitate hydratase AcnA [Brucella/Ochrobactrum group]

Protein Classification

aconitate hydratase( domain architecture ID 11483711)

aconitate hydratase catalyzes the reversible isomerization of citrate and isocitrate via cis-aconitate in the citric acid cycle

EC:  4.2.1.3
Gene Ontology:  GO:0003994|GO:0051539
PubMed:  9020582

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
PRK09277 PRK09277
aconitate hydratase AcnA;
1-895 0e+00

aconitate hydratase AcnA;


:

Pssm-ID: 236445 [Multi-domain]  Cd Length: 888  Bit Score: 1824.35  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028   1 MSHIDSFKCRKTLTVGGKDYVYYSLTEAEKNGLEGVSKLPFSMKVLLENLLRFEDDRSVKKSDIEAVAKWLNDrGSAGAE 80
Cdd:PRK09277   1 MSSTDSFKARKTLEVGGKSYDYYSLRALEAKGLGDISRLPYSLRVLLENLLRNEDGRSVTEEDIEALAEWLPK-AKPDRE 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028  81 IAYRPARVLMQDFTGVPAVVDLAAMRDGLKALGGDPEKINPLVPVDLVIDHSVIVDEFGNPSAFKANVDLEYQRNGERYR 160
Cdd:PRK09277  80 IPFRPARVVMQDFTGVPAVVDLAAMRDAIADLGGDPAKINPLVPVDLVIDHSVQVDYFGTPDAFEKNVELEFERNEERYQ 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 161 FLKWGQQAFKNFRVVPPGTGICHQVNLEYLAQAVWTKEeDGETVAYPDTCVGTDSHTTMVNGLGVLGWGVGGIEAEAAML 240
Cdd:PRK09277 160 FLKWGQKAFDNFRVVPPGTGICHQVNLEYLAPVVWTRE-DGELVAYPDTLVGTDSHTTMINGLGVLGWGVGGIEAEAAML 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 241 GQPVSMLLPEVVGFRLTGKIKEGVTATDLVLTVTQMLRKKGVVGKFVEFFGEGLENMTLADRATIANMGPEYGATCGFFP 320
Cdd:PRK09277 239 GQPSSMLIPEVVGVKLTGKLPEGVTATDLVLTVTEMLRKKGVVGKFVEFFGEGLASLSLADRATIANMAPEYGATCGFFP 318
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 321 VDRETLNYMNTTGRDEHRIELVEAYCRAQGMWRDKGAaDPVFTDILELDMSDVVPSMAGPKRPEGRIALENIASGFATSL 400
Cdd:PRK09277 319 IDEETLDYLRLTGRDEEQVALVEAYAKAQGLWRDPLE-EPVYTDVLELDLSTVEPSLAGPKRPQDRIPLSDVKEAFAKSA 397
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 401 ENEYKKTTGQTARyavEGEDYDLGHGDVAIAAITSCTNTSNPSVLIAAGLLARNAVAKGLKTKPWVKTSLAPGSQVVAAY 480
Cdd:PRK09277 398 ELGVQGFGLDEAE---EGEDYELPDGAVVIAAITSCTNTSNPSVMIAAGLLAKKAVEKGLKVKPWVKTSLAPGSKVVTDY 474
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 481 LESAGLQKDLDALGFNLVGFGCTTCIGNSGPLPAPISKTINEKGLIAAAVLSGNRNFEGRVSPDVQANYLASPPLVVAHA 560
Cdd:PRK09277 475 LEKAGLLPYLEALGFNLVGYGCTTCIGNSGPLPPEIEKAINDNDLVVTAVLSGNRNFEGRIHPLVKANYLASPPLVVAYA 554
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 561 LAGTVTKDLTKEPLGEDQNGNPVFLRDIWPSSQEIQEFIAKNVTRKIFSEKYADVFKGDENWQAVQVPAGQTYAWDDNST 640
Cdd:PRK09277 555 LAGTVDIDLEKDPLGTDKDGNPVYLKDIWPSDEEIDAVVAKAVKPEMFRKEYADVFEGDERWNAIEVPEGPLYDWDPDST 634
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 641 YVQNPPYFVGMGKSAGTIGDVKGARILGLFGDKITTDHISPAGSIKAQSPAGKYLIDHGVGIADFNQYGTRRGNHEVMMR 720
Cdd:PRK09277 635 YIRNPPYFEGMLAEPGPVRDIKGARVLALLGDSITTDHISPAGAIKADSPAGKYLLEHGVEPKDFNSYGSRRGNHEVMMR 714
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 721 GTFANIRIRNHMLgeNGREGGYTIHYPSKEETSIYDAAMQYKAEGVPLVVFAGVEYGNGSSRDWAAKGTNLLGVKAVIAQ 800
Cdd:PRK09277 715 GTFANIRIRNEMV--PGVEGGYTRHFPEGEVMSIYDAAMKYKEEGTPLVVIAGKEYGTGSSRDWAAKGTRLLGVKAVIAE 792
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 801 SFERIHRSNLVGMGIVPFVFEEGTSWQTLGLKGDEMVTIEGLADVRPRQKVDASITFADGTVKKVPLICRIDTLDELDYM 880
Cdd:PRK09277 793 SFERIHRSNLVGMGVLPLQFKPGESRKTLGLDGTETFDIEGLEDLKPGATVTVVITRADGEVVEFPVLCRIDTAVEVDYY 872
                        890
                 ....*....|....*
gi 500733028 881 KNGGILQTVLRDLAA 895
Cdd:PRK09277 873 RNGGILQYVLRDLLA 887
 
Name Accession Description Interval E-value
PRK09277 PRK09277
aconitate hydratase AcnA;
1-895 0e+00

aconitate hydratase AcnA;


Pssm-ID: 236445 [Multi-domain]  Cd Length: 888  Bit Score: 1824.35  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028   1 MSHIDSFKCRKTLTVGGKDYVYYSLTEAEKNGLEGVSKLPFSMKVLLENLLRFEDDRSVKKSDIEAVAKWLNDrGSAGAE 80
Cdd:PRK09277   1 MSSTDSFKARKTLEVGGKSYDYYSLRALEAKGLGDISRLPYSLRVLLENLLRNEDGRSVTEEDIEALAEWLPK-AKPDRE 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028  81 IAYRPARVLMQDFTGVPAVVDLAAMRDGLKALGGDPEKINPLVPVDLVIDHSVIVDEFGNPSAFKANVDLEYQRNGERYR 160
Cdd:PRK09277  80 IPFRPARVVMQDFTGVPAVVDLAAMRDAIADLGGDPAKINPLVPVDLVIDHSVQVDYFGTPDAFEKNVELEFERNEERYQ 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 161 FLKWGQQAFKNFRVVPPGTGICHQVNLEYLAQAVWTKEeDGETVAYPDTCVGTDSHTTMVNGLGVLGWGVGGIEAEAAML 240
Cdd:PRK09277 160 FLKWGQKAFDNFRVVPPGTGICHQVNLEYLAPVVWTRE-DGELVAYPDTLVGTDSHTTMINGLGVLGWGVGGIEAEAAML 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 241 GQPVSMLLPEVVGFRLTGKIKEGVTATDLVLTVTQMLRKKGVVGKFVEFFGEGLENMTLADRATIANMGPEYGATCGFFP 320
Cdd:PRK09277 239 GQPSSMLIPEVVGVKLTGKLPEGVTATDLVLTVTEMLRKKGVVGKFVEFFGEGLASLSLADRATIANMAPEYGATCGFFP 318
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 321 VDRETLNYMNTTGRDEHRIELVEAYCRAQGMWRDKGAaDPVFTDILELDMSDVVPSMAGPKRPEGRIALENIASGFATSL 400
Cdd:PRK09277 319 IDEETLDYLRLTGRDEEQVALVEAYAKAQGLWRDPLE-EPVYTDVLELDLSTVEPSLAGPKRPQDRIPLSDVKEAFAKSA 397
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 401 ENEYKKTTGQTARyavEGEDYDLGHGDVAIAAITSCTNTSNPSVLIAAGLLARNAVAKGLKTKPWVKTSLAPGSQVVAAY 480
Cdd:PRK09277 398 ELGVQGFGLDEAE---EGEDYELPDGAVVIAAITSCTNTSNPSVMIAAGLLAKKAVEKGLKVKPWVKTSLAPGSKVVTDY 474
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 481 LESAGLQKDLDALGFNLVGFGCTTCIGNSGPLPAPISKTINEKGLIAAAVLSGNRNFEGRVSPDVQANYLASPPLVVAHA 560
Cdd:PRK09277 475 LEKAGLLPYLEALGFNLVGYGCTTCIGNSGPLPPEIEKAINDNDLVVTAVLSGNRNFEGRIHPLVKANYLASPPLVVAYA 554
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 561 LAGTVTKDLTKEPLGEDQNGNPVFLRDIWPSSQEIQEFIAKNVTRKIFSEKYADVFKGDENWQAVQVPAGQTYAWDDNST 640
Cdd:PRK09277 555 LAGTVDIDLEKDPLGTDKDGNPVYLKDIWPSDEEIDAVVAKAVKPEMFRKEYADVFEGDERWNAIEVPEGPLYDWDPDST 634
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 641 YVQNPPYFVGMGKSAGTIGDVKGARILGLFGDKITTDHISPAGSIKAQSPAGKYLIDHGVGIADFNQYGTRRGNHEVMMR 720
Cdd:PRK09277 635 YIRNPPYFEGMLAEPGPVRDIKGARVLALLGDSITTDHISPAGAIKADSPAGKYLLEHGVEPKDFNSYGSRRGNHEVMMR 714
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 721 GTFANIRIRNHMLgeNGREGGYTIHYPSKEETSIYDAAMQYKAEGVPLVVFAGVEYGNGSSRDWAAKGTNLLGVKAVIAQ 800
Cdd:PRK09277 715 GTFANIRIRNEMV--PGVEGGYTRHFPEGEVMSIYDAAMKYKEEGTPLVVIAGKEYGTGSSRDWAAKGTRLLGVKAVIAE 792
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 801 SFERIHRSNLVGMGIVPFVFEEGTSWQTLGLKGDEMVTIEGLADVRPRQKVDASITFADGTVKKVPLICRIDTLDELDYM 880
Cdd:PRK09277 793 SFERIHRSNLVGMGVLPLQFKPGESRKTLGLDGTETFDIEGLEDLKPGATVTVVITRADGEVVEFPVLCRIDTAVEVDYY 872
                        890
                 ....*....|....*
gi 500733028 881 KNGGILQTVLRDLAA 895
Cdd:PRK09277 873 RNGGILQYVLRDLLA 887
AcnA COG1048
Aconitase A [Energy production and conversion]; Aconitase A is part of the Pathway/BioSystem: ...
5-895 0e+00

Aconitase A [Energy production and conversion]; Aconitase A is part of the Pathway/BioSystem: Lysine biosynthesisTCA cycle


Pssm-ID: 440669 [Multi-domain]  Cd Length: 891  Bit Score: 1750.37  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028   5 DSFKCRKTLTVGGKDYVYYSLTEAEKNGlEGVSKLPFSMKVLLENLLRFEDDRSVKKSDIEAVAKWLNDRGSaGAEIAYR 84
Cdd:COG1048    3 DSFKARKTLTVGGKPYTYYSLPALEEAG-GDISRLPYSLKILLENLLRNEDGETVTEEDIKALANWLPKARG-DDEIPFR 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028  85 PARVLMQDFTGVPAVVDLAAMRDGLKALGGDPEKINPLVPVDLVIDHSVIVDEFGNPSAFKANVDLEYQRNGERYRFLKW 164
Cdd:COG1048   81 PARVLMQDFTGVPAVVDLAAMRDAVARLGGDPKKINPLVPVDLVIDHSVQVDYFGTPDALEKNLELEFERNRERYQFLKW 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 165 GQQAFKNFRVVPPGTGICHQVNLEYLAQAVWTKEEDGETVAYPDTCVGTDSHTTMVNglgvlgwgvggIEAEAAMLGQPV 244
Cdd:COG1048  161 GQQAFDNFRVVPPGTGIVHQVNLEYLAFVVWTREEDGETVAYPDTLVGTDSHTTMINglgvlgwgvggIEAEAAMLGQPV 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 245 SMLLPEVVGFRLTGKIKEGVTATDLVLTVTQMLRKKGVVGKFVEFFGEGLENMTLADRATIANMGPEYGATCGFFPVDRE 324
Cdd:COG1048  241 SMLIPEVVGVKLTGKLPEGVTATDLVLTVTEMLRKKGVVGKFVEFFGPGLASLSLADRATIANMAPEYGATCGFFPVDEE 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 325 TLNYMNTTGRDEHRIELVEAYCRAQGMWRDKGAADPVFTDILELDMSDVVPSMAGPKRPEGRIALENIASGFATSLENEY 404
Cdd:COG1048  321 TLDYLRLTGRSEEQIELVEAYAKAQGLWRDPDAPEPYYSDVLELDLSTVEPSLAGPKRPQDRIPLSDLKEAFRAALAAPV 400
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 405 KKTTGQTARYAVEGEDYDLGHGDVAIAAITSCTNTSNPSVLIAAGLLARNAVAKGLKTKPWVKTSLAPGSQVVAAYLESA 484
Cdd:COG1048  401 GEELDKPVRVEVDGEEFELGHGAVVIAAITSCTNTSNPSVMIAAGLLAKKAVEKGLKVKPWVKTSLAPGSKVVTDYLERA 480
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 485 GLQKDLDALGFNLVGFGCTTCIGNSGPLPAPISKTINEKGLIAAAVLSGNRNFEGRVSPDVQANYLASPPLVVAHALAGT 564
Cdd:COG1048  481 GLLPYLEALGFNVVGYGCTTCIGNSGPLPPEISEAIEENDLVVAAVLSGNRNFEGRIHPDVKANFLASPPLVVAYALAGT 560
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 565 VTKDLTKEPLGEDQNGNPVFLRDIWPSSQEIQEFIAKNVTRKIFSEKYADVFKGDENWQAVQVPAGQTYAWDDNSTYVQN 644
Cdd:COG1048  561 VDIDLTTDPLGTDKDGKPVYLKDIWPSGEEIPAAVFKAVTPEMFRARYADVFDGDERWQALEVPAGELYDWDPDSTYIRR 640
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 645 PPYFVGMGKSAGTIGDVKGARILGLFGDKITTDHISPAGSIKAQSPAGKYLIDHGVGIADFNQYGTRRGNHEVMMRGTFA 724
Cdd:COG1048  641 PPFFEGLQLEPEPFKDIKGARVLAKLGDSITTDHISPAGAIKADSPAGRYLLEHGVEPKDFNSYGSRRGNHEVMMRGTFA 720
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 725 NIRIRNHMLGenGREGGYTIHYPSKEETSIYDAAMQYKAEGVPLVVFAGVEYGNGSSRDWAAKGTNLLGVKAVIAQSFER 804
Cdd:COG1048  721 NIRIKNLLAP--GTEGGYTKHQPTGEVMSIYDAAMRYKAEGTPLVVLAGKEYGTGSSRDWAAKGTRLLGVKAVIAESFER 798
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 805 IHRSNLVGMGIVPFVFEEGTSWQTLGLKGDEMVTIEGLAD-VRPRQKVDASITFADGTVKKVPLICRIDTLDELDYMKNG 883
Cdd:COG1048  799 IHRSNLVGMGVLPLQFPEGESAESLGLTGDETFDIEGLDEgLAPGKTVTVTATRADGSTEEFPVLHRIDTPVEVEYYRAG 878
                        890
                 ....*....|..
gi 500733028 884 GILQTVLRDLAA 895
Cdd:COG1048  879 GILQYVLRQLLA 890
aconitase_1 TIGR01341
aconitate hydratase 1; This model represents one form of the TCA cycle enzyme aconitate ...
18-893 0e+00

aconitate hydratase 1; This model represents one form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It is found in bacteria, archaea, and eukaryotic cytosol. It has been shown to act also as an iron-responsive element binding protein in animals and may have the same role in other eukaryotes. [Energy metabolism, TCA cycle]


Pssm-ID: 273562 [Multi-domain]  Cd Length: 876  Bit Score: 1336.75  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028   18 KDYVYYSLTEAEKNGlEGVSKLPFSMKVLLENLLRFEDDRSVKKSDIEAVAKWLNDRgSAGAEIAYRPARVLMQDFTGVP 97
Cdd:TIGR01341   1 KTYYYYSLKALEESG-GKISKLPYSIRILLESVLRNLDGFSITEEDIENILKWKIGE-VADTEIAFKPARVVMQDFTGVP 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028   98 AVVDLAAMRDGLKALGGDPEKINPLVPVDLVIDHSVIVDEFGNPSAFKANVDLEYQRNGERYRFLKWGQQAFKNFRVVPP 177
Cdd:TIGR01341  79 AVVDLAAMREAMKNLGGDPKKINPLVPVDLVIDHSVQVDYYGTEYALEFNMELEFERNLERYQFLKWAQKAFRNFRVVPP 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028  178 GTGICHQVNLEYLAQAVWTKEEDGETVAYPDTCVGTDSHTTMVNGLGVLGWGVGGIEAEAAMLGQPVSMLLPEVVGFRLT 257
Cdd:TIGR01341 159 GTGIIHQVNLEYLATVVFKAEVDGELTAYPDSLVGTDSHTTMINGLGVLGWGVGGIEAEAAMLGQPYYMNVPEVIGVKLT 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028  258 GKIKEGVTATDLVLTVTQMLRKKGVVGKFVEFFGEGLENMTLADRATIANMGPEYGATCGFFPVDRETLNYMNTTGRDEH 337
Cdd:TIGR01341 239 GKLQEGVTATDLVLTVTQMLRKKGVVGKFVEFFGPGLSELSLADRATIANMAPEYGATCGFFPIDDVTLQYLRLTGRDGD 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028  338 RIELVEAYCRAQGMWRDkGAADPVFTDILELDMSDVVPSMAGPKRPEGRIALENIASGFATSLE----NEYKKTTGQTAR 413
Cdd:TIGR01341 319 HVELVEKYARAQGLFYD-DSEEPRYTDVVELDLSDVEPSVAGPKRPQDRIPLREVKAKFSKELEknggDKGFTLRKEPLK 397
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028  414 YAVEGEDYDLGHGDVAIAAITSCTNTSNPSVLIAAGLLARNAVAKGLKTKPWVKTSLAPGSQVVAAYLESAGLQKDLDAL 493
Cdd:TIGR01341 398 KKVNGQNKQLEDGAVVIAAITSCTNTSNPSVMLGAGLLAKKAVELGLKVPPYVKTSLAPGSKVVTDYLAESGLLPYLEEL 477
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028  494 GFNLVGFGCTTCIGNSGPLPAPISKTINEKGLIAAAVLSGNRNFEGRVSPDVQANYLASPPLVVAHALAGTVTKDLTKEP 573
Cdd:TIGR01341 478 GFNLVGYGCTTCIGNSGPLPKYVEEAIKKNDLEVYAVLSGNRNFEGRIHPLVKGNYLASPPLVVAYALAGNIDINLYTEP 557
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028  574 LGEDQNGNPVFLRDIWPSSQEIQEFIAKNVTRKIFSEKYADVFKGDENWQAVQVPAGQTYAWDDNSTYVQNPPYFVGMGK 653
Cdd:TIGR01341 558 IGTDKDGKPVYLRDIWPSNKEIAAYVNMAVKPEMFKKEYENIFEGNERWNSIKTPSGDTYSWDEKSTYIRLPPFFEEMKQ 637
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028  654 SAGTIGDVKGARILGLFGDKITTDHISPAGSIKAQSPAGKYLIDHGVGIADFNQYGTRRGNHEVMMRGTFANIRIRNHML 733
Cdd:TIGR01341 638 DPEEVEDIKGARILLLLGDSITTDHISPAGSITKDSPAGKYLQERGVSRRDFNSYGSRRGNHEVMMRGTFANIRIKNLMV 717
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028  734 geNGREGGYTIHYPSKEETSIYDAAMQYKAEGVPLVVFAGVEYGNGSSRDWAAKGTNLLGVKAVIAQSFERIHRSNLVGM 813
Cdd:TIGR01341 718 --KGKEGGYTVHFPDGKVASVYDAAMQYKKEGTPLVVIAGKEYGSGSSRDWAAKGTKLLGVKAVIAESFERIHRSNLVGM 795
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028  814 GIVPFVFEEGTSWQTLGLKGDEMVTIEGLADVRPRQKVDASITFADGTVKKVPLICRIDTLDELDYMKNGGILQTVLRDL 893
Cdd:TIGR01341 796 GVIPLQFPQGEDAETLGLTGDETIDIDGIKDLKPGKEVTVTFTNSKGEKITFKCVLRIDTEVELDYYKHGGILQYVLRKF 875
AcnA_IRP cd01586
Aconitase A catalytic domain; Aconitase A catalytic domain. This is the major form of the TCA ...
87-565 0e+00

Aconitase A catalytic domain; Aconitase A catalytic domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydrolyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group also includes sequences that have been shown to act as an iron-responsive element (IRE) binding protein in animals and may have the same role in other eukaryotes.


Pssm-ID: 153136  Cd Length: 404  Bit Score: 749.90  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028  87 RVLMQDFTGVPAVVDLAAMRDGLKALGGDPEKINPLVPVDLVIDHSVIVDEFGNPSAFKANVDLEYQRNGERYRFLKWGQ 166
Cdd:cd01586    1 RVILQDFTGVPAVVDLAAMRDAVKRLGGDPEKINPLIPVDLVIDHSVQVDFYGTADALAKNMKLEFERNRERYEFLKWGQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 167 QAFKNFRVVPPGTGICHQVNLEYLAQAVWTKEEDGETVAYPDTCVGTDSHTTMVNGLGVLGWGVGGIEAEAAMLGQPVSM 246
Cdd:cd01586   81 KAFKNLRVVPPGTGIIHQVNLEYLARVVFTSEEDGDGVAYPDSVVGTDSHTTMINGLGVLGWGVGGIEAEAVMLGQPISM 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 247 LLPEVVGFRLTGKIKEGVTATDLVLTVTQMLRKKGVVGKFVEFFGEGLENMTLADRATIANMGPEYGATCGFFPVDretl 326
Cdd:cd01586  161 LLPEVVGVKLTGKLRPGVTATDLVLTVTQMLRKVGVVGKFVEFFGPGVAKLSVADRATIANMAPEYGATCGFFPVD---- 236
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 327 nymnttgrdehrielveaycraqgmwrdkgaadpvfTDILELDMSDVVPSMAGPKRPEGRIALeniasgfatsleneykk 406
Cdd:cd01586  237 ------------------------------------TQVVELDLSTVEPSVSGPKRPQDRVPL----------------- 263
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 407 ttgqtaryavegedydlgHGDVAIAAITSCTNTSNPSVLIAAGLLARNAVAKGLKTKPWVKTSLAPGSQVVAAYLESAGL 486
Cdd:cd01586  264 ------------------HGSVVIAAITSCTNTSNPSVMLAAGLLAKKAVELGLKVKPYVKTSLAPGSRVVTKYLEASGL 325
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 500733028 487 QKDLDALGFNLVGFGCTTCIGNSGPLPAPISKTINEKGLIAAAVLSGNRNFEGRVSPDVQANYLASPPLVVAHALAGTV 565
Cdd:cd01586  326 LPYLEKLGFHVVGYGCTTCIGNSGPLPEEVEEAIKENDLVVAAVLSGNRNFEGRIHPLVRANYLASPPLVVAYALAGTV 404
Aconitase pfam00330
Aconitase family (aconitate hydratase);
80-563 0e+00

Aconitase family (aconitate hydratase);


Pssm-ID: 459764  Cd Length: 460  Bit Score: 647.56  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028   80 EIAYRPARVLMQDFTGVPAVVDLAAMRDGLKALGGDPEKINPLVPVDLVIDHSvivdefgnPSAFKANVDLEYQRNGERY 159
Cdd:pfam00330  15 SLLYIPDRVLMHDVTSPQAFVDLRAAGRAVRRPGGTPATIDHLVPTDLVIDHA--------PDALDKNIEDEISRNKEQY 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028  160 RFLKWGQQAFkNFRVVPPGTGICHQVNLEYLaqavwtkeedgetVAYPD-TCVGTDSHTTMVNGLGVLGWGVGGIEAEAA 238
Cdd:pfam00330  87 DFLEWNAKKF-GIRFVPPGQGIVHQVGLEYG-------------LALPGmTIVGTDSHTTTHGGLGALAFGVGGSEAEHV 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028  239 MLGQPVSMLLPEVVGFRLTGKIKEGVTATDLVLTVTQMLRKKGVVGKFVEFFGEGLENMTLADRATIANMGPEYGATCGF 318
Cdd:pfam00330 153 LATQPLEMKKPKVVGVKLTGKLPPGVTAKDVILAIIGKLGVKGGTGKVVEFFGPGVRSLSMEGRATICNMAIEYGATAGL 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028  319 FPVDRETLNYMNTTGRDEHRIelVEAYCRAQGMWRDKGAADPVFTDILELDMSDVVPSMAGPKRPEGRIAL-ENIASGFA 397
Cdd:pfam00330 233 FPPDETTFEYLRATGRPEAPK--GEAYDKAVAWKTLASDPGAEYDKVVEIDLSTIEPMVTGPTRPQDAVPLsELVPDPFA 310
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028  398 TSLENEYKKttgQTARYAVEGEDYDLGHGDVAIAAITSCTNTSNPSVLIAAGLLArNAVAKGLKTKPWVKTSLAPGSQVV 477
Cdd:pfam00330 311 DAVKRKAAE---RALEYMGLGPGTPLSDGKVDIAFIGSCTNSSIEDLRAAAGLLK-KAVEKGLKVAPGVKASVVPGSEVV 386
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028  478 AAYLESAGLQKDLDALGFNLVGFGCTTCIGNSGPLPApisktiNEkgliaAAVLSGNRNFEGRVSPDVQAnYLASPPLVV 557
Cdd:pfam00330 387 RAYAEAEGLDKILEEAGFEWRGPGCSMCIGNSDRLPP------GE-----RCVSSSNRNFEGRQGPGGRT-HLASPALVA 454

                  ....*.
gi 500733028  558 AHALAG 563
Cdd:pfam00330 455 AAAIAG 460
 
Name Accession Description Interval E-value
PRK09277 PRK09277
aconitate hydratase AcnA;
1-895 0e+00

aconitate hydratase AcnA;


Pssm-ID: 236445 [Multi-domain]  Cd Length: 888  Bit Score: 1824.35  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028   1 MSHIDSFKCRKTLTVGGKDYVYYSLTEAEKNGLEGVSKLPFSMKVLLENLLRFEDDRSVKKSDIEAVAKWLNDrGSAGAE 80
Cdd:PRK09277   1 MSSTDSFKARKTLEVGGKSYDYYSLRALEAKGLGDISRLPYSLRVLLENLLRNEDGRSVTEEDIEALAEWLPK-AKPDRE 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028  81 IAYRPARVLMQDFTGVPAVVDLAAMRDGLKALGGDPEKINPLVPVDLVIDHSVIVDEFGNPSAFKANVDLEYQRNGERYR 160
Cdd:PRK09277  80 IPFRPARVVMQDFTGVPAVVDLAAMRDAIADLGGDPAKINPLVPVDLVIDHSVQVDYFGTPDAFEKNVELEFERNEERYQ 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 161 FLKWGQQAFKNFRVVPPGTGICHQVNLEYLAQAVWTKEeDGETVAYPDTCVGTDSHTTMVNGLGVLGWGVGGIEAEAAML 240
Cdd:PRK09277 160 FLKWGQKAFDNFRVVPPGTGICHQVNLEYLAPVVWTRE-DGELVAYPDTLVGTDSHTTMINGLGVLGWGVGGIEAEAAML 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 241 GQPVSMLLPEVVGFRLTGKIKEGVTATDLVLTVTQMLRKKGVVGKFVEFFGEGLENMTLADRATIANMGPEYGATCGFFP 320
Cdd:PRK09277 239 GQPSSMLIPEVVGVKLTGKLPEGVTATDLVLTVTEMLRKKGVVGKFVEFFGEGLASLSLADRATIANMAPEYGATCGFFP 318
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 321 VDRETLNYMNTTGRDEHRIELVEAYCRAQGMWRDKGAaDPVFTDILELDMSDVVPSMAGPKRPEGRIALENIASGFATSL 400
Cdd:PRK09277 319 IDEETLDYLRLTGRDEEQVALVEAYAKAQGLWRDPLE-EPVYTDVLELDLSTVEPSLAGPKRPQDRIPLSDVKEAFAKSA 397
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 401 ENEYKKTTGQTARyavEGEDYDLGHGDVAIAAITSCTNTSNPSVLIAAGLLARNAVAKGLKTKPWVKTSLAPGSQVVAAY 480
Cdd:PRK09277 398 ELGVQGFGLDEAE---EGEDYELPDGAVVIAAITSCTNTSNPSVMIAAGLLAKKAVEKGLKVKPWVKTSLAPGSKVVTDY 474
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 481 LESAGLQKDLDALGFNLVGFGCTTCIGNSGPLPAPISKTINEKGLIAAAVLSGNRNFEGRVSPDVQANYLASPPLVVAHA 560
Cdd:PRK09277 475 LEKAGLLPYLEALGFNLVGYGCTTCIGNSGPLPPEIEKAINDNDLVVTAVLSGNRNFEGRIHPLVKANYLASPPLVVAYA 554
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 561 LAGTVTKDLTKEPLGEDQNGNPVFLRDIWPSSQEIQEFIAKNVTRKIFSEKYADVFKGDENWQAVQVPAGQTYAWDDNST 640
Cdd:PRK09277 555 LAGTVDIDLEKDPLGTDKDGNPVYLKDIWPSDEEIDAVVAKAVKPEMFRKEYADVFEGDERWNAIEVPEGPLYDWDPDST 634
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 641 YVQNPPYFVGMGKSAGTIGDVKGARILGLFGDKITTDHISPAGSIKAQSPAGKYLIDHGVGIADFNQYGTRRGNHEVMMR 720
Cdd:PRK09277 635 YIRNPPYFEGMLAEPGPVRDIKGARVLALLGDSITTDHISPAGAIKADSPAGKYLLEHGVEPKDFNSYGSRRGNHEVMMR 714
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 721 GTFANIRIRNHMLgeNGREGGYTIHYPSKEETSIYDAAMQYKAEGVPLVVFAGVEYGNGSSRDWAAKGTNLLGVKAVIAQ 800
Cdd:PRK09277 715 GTFANIRIRNEMV--PGVEGGYTRHFPEGEVMSIYDAAMKYKEEGTPLVVIAGKEYGTGSSRDWAAKGTRLLGVKAVIAE 792
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 801 SFERIHRSNLVGMGIVPFVFEEGTSWQTLGLKGDEMVTIEGLADVRPRQKVDASITFADGTVKKVPLICRIDTLDELDYM 880
Cdd:PRK09277 793 SFERIHRSNLVGMGVLPLQFKPGESRKTLGLDGTETFDIEGLEDLKPGATVTVVITRADGEVVEFPVLCRIDTAVEVDYY 872
                        890
                 ....*....|....*
gi 500733028 881 KNGGILQTVLRDLAA 895
Cdd:PRK09277 873 RNGGILQYVLRDLLA 887
AcnA COG1048
Aconitase A [Energy production and conversion]; Aconitase A is part of the Pathway/BioSystem: ...
5-895 0e+00

Aconitase A [Energy production and conversion]; Aconitase A is part of the Pathway/BioSystem: Lysine biosynthesisTCA cycle


Pssm-ID: 440669 [Multi-domain]  Cd Length: 891  Bit Score: 1750.37  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028   5 DSFKCRKTLTVGGKDYVYYSLTEAEKNGlEGVSKLPFSMKVLLENLLRFEDDRSVKKSDIEAVAKWLNDRGSaGAEIAYR 84
Cdd:COG1048    3 DSFKARKTLTVGGKPYTYYSLPALEEAG-GDISRLPYSLKILLENLLRNEDGETVTEEDIKALANWLPKARG-DDEIPFR 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028  85 PARVLMQDFTGVPAVVDLAAMRDGLKALGGDPEKINPLVPVDLVIDHSVIVDEFGNPSAFKANVDLEYQRNGERYRFLKW 164
Cdd:COG1048   81 PARVLMQDFTGVPAVVDLAAMRDAVARLGGDPKKINPLVPVDLVIDHSVQVDYFGTPDALEKNLELEFERNRERYQFLKW 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 165 GQQAFKNFRVVPPGTGICHQVNLEYLAQAVWTKEEDGETVAYPDTCVGTDSHTTMVNglgvlgwgvggIEAEAAMLGQPV 244
Cdd:COG1048  161 GQQAFDNFRVVPPGTGIVHQVNLEYLAFVVWTREEDGETVAYPDTLVGTDSHTTMINglgvlgwgvggIEAEAAMLGQPV 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 245 SMLLPEVVGFRLTGKIKEGVTATDLVLTVTQMLRKKGVVGKFVEFFGEGLENMTLADRATIANMGPEYGATCGFFPVDRE 324
Cdd:COG1048  241 SMLIPEVVGVKLTGKLPEGVTATDLVLTVTEMLRKKGVVGKFVEFFGPGLASLSLADRATIANMAPEYGATCGFFPVDEE 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 325 TLNYMNTTGRDEHRIELVEAYCRAQGMWRDKGAADPVFTDILELDMSDVVPSMAGPKRPEGRIALENIASGFATSLENEY 404
Cdd:COG1048  321 TLDYLRLTGRSEEQIELVEAYAKAQGLWRDPDAPEPYYSDVLELDLSTVEPSLAGPKRPQDRIPLSDLKEAFRAALAAPV 400
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 405 KKTTGQTARYAVEGEDYDLGHGDVAIAAITSCTNTSNPSVLIAAGLLARNAVAKGLKTKPWVKTSLAPGSQVVAAYLESA 484
Cdd:COG1048  401 GEELDKPVRVEVDGEEFELGHGAVVIAAITSCTNTSNPSVMIAAGLLAKKAVEKGLKVKPWVKTSLAPGSKVVTDYLERA 480
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 485 GLQKDLDALGFNLVGFGCTTCIGNSGPLPAPISKTINEKGLIAAAVLSGNRNFEGRVSPDVQANYLASPPLVVAHALAGT 564
Cdd:COG1048  481 GLLPYLEALGFNVVGYGCTTCIGNSGPLPPEISEAIEENDLVVAAVLSGNRNFEGRIHPDVKANFLASPPLVVAYALAGT 560
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 565 VTKDLTKEPLGEDQNGNPVFLRDIWPSSQEIQEFIAKNVTRKIFSEKYADVFKGDENWQAVQVPAGQTYAWDDNSTYVQN 644
Cdd:COG1048  561 VDIDLTTDPLGTDKDGKPVYLKDIWPSGEEIPAAVFKAVTPEMFRARYADVFDGDERWQALEVPAGELYDWDPDSTYIRR 640
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 645 PPYFVGMGKSAGTIGDVKGARILGLFGDKITTDHISPAGSIKAQSPAGKYLIDHGVGIADFNQYGTRRGNHEVMMRGTFA 724
Cdd:COG1048  641 PPFFEGLQLEPEPFKDIKGARVLAKLGDSITTDHISPAGAIKADSPAGRYLLEHGVEPKDFNSYGSRRGNHEVMMRGTFA 720
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 725 NIRIRNHMLGenGREGGYTIHYPSKEETSIYDAAMQYKAEGVPLVVFAGVEYGNGSSRDWAAKGTNLLGVKAVIAQSFER 804
Cdd:COG1048  721 NIRIKNLLAP--GTEGGYTKHQPTGEVMSIYDAAMRYKAEGTPLVVLAGKEYGTGSSRDWAAKGTRLLGVKAVIAESFER 798
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 805 IHRSNLVGMGIVPFVFEEGTSWQTLGLKGDEMVTIEGLAD-VRPRQKVDASITFADGTVKKVPLICRIDTLDELDYMKNG 883
Cdd:COG1048  799 IHRSNLVGMGVLPLQFPEGESAESLGLTGDETFDIEGLDEgLAPGKTVTVTATRADGSTEEFPVLHRIDTPVEVEYYRAG 878
                        890
                 ....*....|..
gi 500733028 884 GILQTVLRDLAA 895
Cdd:COG1048  879 GILQYVLRQLLA 890
acnA PRK12881
aconitate hydratase AcnA;
1-895 0e+00

aconitate hydratase AcnA;


Pssm-ID: 237246 [Multi-domain]  Cd Length: 889  Bit Score: 1471.70  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028   1 MSHiDSFKCRKTLTVGGKDYVYYSLTEAEKNGLEGVSKLPFSMKVLLENLLRFEDDRSVKKSDIEAVAKWLnDRGSAGAE 80
Cdd:PRK12881   1 MAH-NLHKTLKEFDVGGKTYKFYSLPALGKELGGDLARLPVSLRVLLENLLRNEDGKKVTEEHLEALANWL-PERKSDDE 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028  81 IAYRPARVLMQDFTGVPAVVDLAAMRDGLKALGGDPEKINPLVPVDLVIDHSVIVDEFGNPSAFKANVDLEYQRNGERYR 160
Cdd:PRK12881  79 IPFVPARVVMQDFTGVPALVDLAAMRDAAAEAGGDPAKINPLVPVDLVVDHSVAVDYFGQKDALDLNMKIEFQRNAERYQ 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 161 FLKWGQQAFKNFRVVPPGTGICHQVNLEYLAQAVWTKEEDGETVAYPDTCVGTDSHTTMVNGLGVLGWGVGGIEAEAAML 240
Cdd:PRK12881 159 FLKWGMQAFDNFRVVPPGTGIMHQVNLEYLARVVHTKEDDGDTVAYPDTLVGTDSHTTMINGIGVLGWGVGGIEAEAVML 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 241 GQPVSMLLPEVVGFRLTGKIKEGVTATDLVLTVTQMLRKKGVVGKFVEFFGEGLENMTLADRATIANMGPEYGATCGFFP 320
Cdd:PRK12881 239 GQPVYMLIPDVVGVELTGKLREGVTATDLVLTVTEMLRKEGVVGKFVEFFGEGVASLTLGDRATIANMAPEYGATMGFFP 318
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 321 VDRETLNYMNTTGRDEHRIELVEAYCRAQGMWRDKGaADPVFTDILELDMSDVVPSMAGPKRPEGRIALENIASGFATSL 400
Cdd:PRK12881 319 VDEQTLDYLRLTGRTEAQIALVEAYAKAQGLWGDPK-AEPRYTRTLELDLSTVAPSLAGPKRPQDRIALGNVKSAFSDLF 397
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 401 EneykkTTGQTARYAVEGED---YDLGHGDVAIAAITSCTNTSNPSVLIAAGLLARNAVAKGLKTKPWVKTSLAPGSQVV 477
Cdd:PRK12881 398 S-----KPVAENGFAKKAQTsngVDLPDGAVAIAAITSCTNTSNPSVLIAAGLLAKKAVERGLTVKPWVKTSLAPGSKVV 472
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 478 AAYLESAGLQKDLDALGFNLVGFGCTTCIGNSGPLPAPISKTINEKGLIAAAVLSGNRNFEGRVSPDVQANYLASPPLVV 557
Cdd:PRK12881 473 TEYLERAGLLPYLEKLGFGIVGYGCTTCIGNSGPLTPEIEQAITKNDLVAAAVLSGNRNFEGRIHPNIKANFLASPPLVV 552
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 558 AHALAGTVTKDLTKEPLGEDQNGNPVFLRDIWPSSQEIQEFIAKNVTRKIFSEKYADVFKGDENWQAVQVPAGQTYAWDD 637
Cdd:PRK12881 553 AYALAGTVRRDLMTEPLGKGKDGRPVYLKDIWPSSAEIDALVAFAVDPEDFRKNYAEVFKGSELWAAIEAPDGPLYDWDP 632
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 638 NSTYVQNPPYFVGMGKSAGTIGDVKGARILGLFGDKITTDHISPAGSIKAQSPAGKYLIDHGVGIADFNQYGTRRGNHEV 717
Cdd:PRK12881 633 KSTYIRRPPFFDFSMGPAASIATVKGARPLAVLGDSITTDHISPAGAIKADSPAGKYLKENGVPKADFNSYGSRRGNHEV 712
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 718 MMRGTFANIRIRNHMLGenGREGGYTIHYPSKEETSIYDAAMQYKAEGVPLVVFAGVEYGNGSSRDWAAKGTNLLGVKAV 797
Cdd:PRK12881 713 MMRGTFANVRIKNLMIP--GKEGGLTLHQPSGEVLSIYDAAMRYQAAGTPLVVIAGEEYGTGSSRDWAAKGTRLLGVKAV 790
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 798 IAQSFERIHRSNLVGMGIVPFVFEEGTSWQTLGLKGDEMVTIEGL-ADVRPRQKVDASITFADGTVKKVPLICRIDTLDE 876
Cdd:PRK12881 791 IAESFERIHRSNLVGMGVLPLQFKGGDSRQSLGLTGGETFDIEGLpGEIKPRQDVTLVIHRADGSTERVPVLCRIDTPIE 870
                        890
                 ....*....|....*....
gi 500733028 877 LDYMKNGGILQTVLRDLAA 895
Cdd:PRK12881 871 VDYYKAGGILPYVLRQLLA 889
aconitase_1 TIGR01341
aconitate hydratase 1; This model represents one form of the TCA cycle enzyme aconitate ...
18-893 0e+00

aconitate hydratase 1; This model represents one form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It is found in bacteria, archaea, and eukaryotic cytosol. It has been shown to act also as an iron-responsive element binding protein in animals and may have the same role in other eukaryotes. [Energy metabolism, TCA cycle]


Pssm-ID: 273562 [Multi-domain]  Cd Length: 876  Bit Score: 1336.75  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028   18 KDYVYYSLTEAEKNGlEGVSKLPFSMKVLLENLLRFEDDRSVKKSDIEAVAKWLNDRgSAGAEIAYRPARVLMQDFTGVP 97
Cdd:TIGR01341   1 KTYYYYSLKALEESG-GKISKLPYSIRILLESVLRNLDGFSITEEDIENILKWKIGE-VADTEIAFKPARVVMQDFTGVP 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028   98 AVVDLAAMRDGLKALGGDPEKINPLVPVDLVIDHSVIVDEFGNPSAFKANVDLEYQRNGERYRFLKWGQQAFKNFRVVPP 177
Cdd:TIGR01341  79 AVVDLAAMREAMKNLGGDPKKINPLVPVDLVIDHSVQVDYYGTEYALEFNMELEFERNLERYQFLKWAQKAFRNFRVVPP 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028  178 GTGICHQVNLEYLAQAVWTKEEDGETVAYPDTCVGTDSHTTMVNGLGVLGWGVGGIEAEAAMLGQPVSMLLPEVVGFRLT 257
Cdd:TIGR01341 159 GTGIIHQVNLEYLATVVFKAEVDGELTAYPDSLVGTDSHTTMINGLGVLGWGVGGIEAEAAMLGQPYYMNVPEVIGVKLT 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028  258 GKIKEGVTATDLVLTVTQMLRKKGVVGKFVEFFGEGLENMTLADRATIANMGPEYGATCGFFPVDRETLNYMNTTGRDEH 337
Cdd:TIGR01341 239 GKLQEGVTATDLVLTVTQMLRKKGVVGKFVEFFGPGLSELSLADRATIANMAPEYGATCGFFPIDDVTLQYLRLTGRDGD 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028  338 RIELVEAYCRAQGMWRDkGAADPVFTDILELDMSDVVPSMAGPKRPEGRIALENIASGFATSLE----NEYKKTTGQTAR 413
Cdd:TIGR01341 319 HVELVEKYARAQGLFYD-DSEEPRYTDVVELDLSDVEPSVAGPKRPQDRIPLREVKAKFSKELEknggDKGFTLRKEPLK 397
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028  414 YAVEGEDYDLGHGDVAIAAITSCTNTSNPSVLIAAGLLARNAVAKGLKTKPWVKTSLAPGSQVVAAYLESAGLQKDLDAL 493
Cdd:TIGR01341 398 KKVNGQNKQLEDGAVVIAAITSCTNTSNPSVMLGAGLLAKKAVELGLKVPPYVKTSLAPGSKVVTDYLAESGLLPYLEEL 477
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028  494 GFNLVGFGCTTCIGNSGPLPAPISKTINEKGLIAAAVLSGNRNFEGRVSPDVQANYLASPPLVVAHALAGTVTKDLTKEP 573
Cdd:TIGR01341 478 GFNLVGYGCTTCIGNSGPLPKYVEEAIKKNDLEVYAVLSGNRNFEGRIHPLVKGNYLASPPLVVAYALAGNIDINLYTEP 557
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028  574 LGEDQNGNPVFLRDIWPSSQEIQEFIAKNVTRKIFSEKYADVFKGDENWQAVQVPAGQTYAWDDNSTYVQNPPYFVGMGK 653
Cdd:TIGR01341 558 IGTDKDGKPVYLRDIWPSNKEIAAYVNMAVKPEMFKKEYENIFEGNERWNSIKTPSGDTYSWDEKSTYIRLPPFFEEMKQ 637
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028  654 SAGTIGDVKGARILGLFGDKITTDHISPAGSIKAQSPAGKYLIDHGVGIADFNQYGTRRGNHEVMMRGTFANIRIRNHML 733
Cdd:TIGR01341 638 DPEEVEDIKGARILLLLGDSITTDHISPAGSITKDSPAGKYLQERGVSRRDFNSYGSRRGNHEVMMRGTFANIRIKNLMV 717
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028  734 geNGREGGYTIHYPSKEETSIYDAAMQYKAEGVPLVVFAGVEYGNGSSRDWAAKGTNLLGVKAVIAQSFERIHRSNLVGM 813
Cdd:TIGR01341 718 --KGKEGGYTVHFPDGKVASVYDAAMQYKKEGTPLVVIAGKEYGSGSSRDWAAKGTKLLGVKAVIAESFERIHRSNLVGM 795
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028  814 GIVPFVFEEGTSWQTLGLKGDEMVTIEGLADVRPRQKVDASITFADGTVKKVPLICRIDTLDELDYMKNGGILQTVLRDL 893
Cdd:TIGR01341 796 GVIPLQFPQGEDAETLGLTGDETIDIDGIKDLKPGKEVTVTFTNSKGEKITFKCVLRIDTEVELDYYKHGGILQYVLRKF 875
PTZ00092 PTZ00092
aconitate hydratase-like protein; Provisional
8-895 0e+00

aconitate hydratase-like protein; Provisional


Pssm-ID: 240263 [Multi-domain]  Cd Length: 898  Bit Score: 1316.93  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028   8 KCRKTLTVGGkDYVYYSLTEAEKNGLEgvsKLPFSMKVLLENLLRFEDDRSVKKSDIEAVAKWlNDRGSAGAEIAYRPAR 87
Cdd:PTZ00092  18 KVLKTLKDGG-SYKYYSLNELHDPRLK---KLPYSIRVLLESAVRNCDEFDVTSKDVENILNW-EENSKKQIEIPFKPAR 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028  88 VLMQDFTGVPAVVDLAAMRDGLKALGGDPEKINPLVPVDLVIDHSVIVDEFGNPSAFKANVDLEYQRNGERYRFLKWGQQ 167
Cdd:PTZ00092  93 VLLQDFTGVPAVVDLAAMRDAMKRLGGDPAKINPLVPVDLVIDHSVQVDFSRSPDALELNQEIEFERNLERFEFLKWGSK 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 168 AFKNFRVVPPGTGICHQVNLEYLAQAVWtkEEDGetVAYPDTCVGTDSHTTMVNGLGVLGWGVGGIEAEAAMLGQPVSML 247
Cdd:PTZ00092 173 AFKNLLIVPPGSGIVHQVNLEYLARVVF--NKDG--LLYPDSVVGTDSHTTMINGLGVLGWGVGGIEAEAVMLGQPISMV 248
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 248 LPEVVGFRLTGKIKEGVTATDLVLTVTQMLRKKGVVGKFVEFFGEGLENMTLADRATIANMGPEYGATCGFFPVDRETLN 327
Cdd:PTZ00092 249 LPEVVGFKLTGKLSEHVTATDLVLTVTSMLRKRGVVGKFVEFYGPGVKTLSLADRATIANMAPEYGATMGFFPIDEKTLD 328
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 328 YMNTTGRDEHRIELVEAYCRAQGMWRDkGAADPVFTDILELDMSDVVPSMAGPKRPEGRIALENIASGFATSLENEY--- 404
Cdd:PTZ00092 329 YLKQTGRSEEKVELIEKYLKANGLFRT-YAEQIEYSDVLELDLSTVVPSVAGPKRPHDRVPLSDLKKDFTACLSAPVgfk 407
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 405 -----KKTTGQTARYAVEGEDYDLGHGDVAIAAITSCTNTSNPSVLIAAGLLARNAVAKGLKTKPWVKTSLAPGSQVVAA 479
Cdd:PTZ00092 408 gfgipEEKHEKKVKFTYKGKEYTLTHGSVVIAAITSCTNTSNPSVMLAAGLLAKKAVEKGLKVPPYIKTSLSPGSKVVTK 487
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 480 YLESAGLQKDLDALGFNLVGFGCTTCIGNSGPLPAPISKTINEKGLIAAAVLSGNRNFEGRVSPDVQANYLASPPLVVAH 559
Cdd:PTZ00092 488 YLEASGLLKYLEKLGFYTAGYGCMTCIGNSGDLDPEVSEAITNNDLVAAAVLSGNRNFEGRVHPLTRANYLASPPLVVAY 567
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 560 ALAGTVTKDLTKEPLGEDQNGNPVFLRDIWPSSQEIQEFIAKNVTRKIFSEKYADVFKGDENWQAVQVPAGQTYAWDDNS 639
Cdd:PTZ00092 568 ALAGRVNIDFETEPLGSDKTGKPVFLRDIWPSREEIQALEAKYVKPEMFKEVYSNITQGNKQWNELQVPKGKLYEWDEKS 647
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 640 TYVQNPPYFVGMGKSAGTIGDVKGARILGLFGDKITTDHISPAGSIKAQSPAGKYLIDHGVGIADFNQYGTRRGNHEVMM 719
Cdd:PTZ00092 648 TYIHNPPFFQTMELEPPPIKSIENAYCLLNLGDSITTDHISPAGNIAKNSPAAKYLMERGVERKDFNTYGARRGNDEVMV 727
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 720 RGTFANIRIRNHMLGEngrEGGYTIHYPSKEETSIYDAAMQYKAEGVPLVVFAGVEYGNGSSRDWAAKGTNLLGVKAVIA 799
Cdd:PTZ00092 728 RGTFANIRLINKLCGK---VGPNTVHVPTGEKMSIYDAAEKYKQEGVPLIVLAGKEYGSGSSRDWAAKGPYLQGVKAVIA 804
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 800 QSFERIHRSNLVGMGIVPFVFEEGTSWQTLGLKGDEMVTIEG-LADVRPRQKvdasITFADGTVKKVPLICRIDTLDELD 878
Cdd:PTZ00092 805 ESFERIHRSNLVGMGILPLQFLNGENADSLGLTGKEQFSIDLnSGELKPGQD----VTVKTDTGKTFDTILRIDTEVEVE 880
                        890
                 ....*....|....*..
gi 500733028 879 YMKNGGILQTVLRDLAA 895
Cdd:PTZ00092 881 YFKHGGILQYVLRKLVK 897
PLN00070 PLN00070
aconitate hydratase
16-895 0e+00

aconitate hydratase


Pssm-ID: 215047 [Multi-domain]  Cd Length: 936  Bit Score: 1115.27  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028  16 GGKDYVYYSLTEAEKNGLEgvsKLPFSMKVLLENLLRFEDDRSVKKSDIEAVAKWLNDrGSAGAEIAYRPARVLMQDFTG 95
Cdd:PLN00070  57 GGEFGKYYSLPALNDPRID---KLPYSIRILLESAIRNCDNFQVTKEDVEKIIDWENT-SPKQVEIPFKPARVLLQDFTG 132
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028  96 VPAVVDLAAMRDGLKALGGDPEKINPLVPVDLVIDHSVIVDEFGNPSAFKANVDLEYQRNGERYRFLKWGQQAFKNFRVV 175
Cdd:PLN00070 133 VPAVVDLACMRDAMNNLGGDPNKINPLVPVDLVIDHSVQVDVARSENAVQANMELEFQRNKERFAFLKWGSTAFQNMLVV 212
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 176 PPGTGICHQVNLEYLAQAVWTKeeDGetVAYPDTCVGTDSHTTMVNGLGVLGWGVGGIEAEAAMLGQPVSMLLPEVVGFR 255
Cdd:PLN00070 213 PPGSGIVHQVNLEYLGRVVFNT--DG--ILYPDSVVGTDSHTTMIDGLGVAGWGVGGIEAEAAMLGQPMSMVLPGVVGFK 288
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 256 LTGKIKEGVTATDLVLTVTQMLRKKGVVGKFVEFFGEGLENMTLADRATIANMGPEYGATCGFFPVDRETLNYMNTTGRD 335
Cdd:PLN00070 289 LSGKLRDGVTATDLVLTVTQMLRKHGVVGKFVEFYGEGMSELSLADRATIANMSPEYGATMGFFPVDHVTLQYLKLTGRS 368
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 336 EHRIELVEAYCRAQGMWRD--KGAADPVFTDILELDMSDVVPSMAGPKRPEGRIALENIASGFATSLENEY--------K 405
Cdd:PLN00070 369 DETVAMIEAYLRANKMFVDynEPQQERVYSSYLELDLEDVEPCISGPKRPHDRVPLKEMKADWHSCLDNKVgfkgfavpK 448
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 406 KTTGQTARYAVEGEDYDLGHGDVAIAAITSCTNTSNPSVLIAAGLLARNAVAKGLKTKPWVKTSLAPGSQVVAAYLESAG 485
Cdd:PLN00070 449 EAQSKVAKFSFHGQPAELRHGSVVIAAITSCTNTSNPSVMLGAGLVAKKACELGLEVKPWIKTSLAPGSGVVTKYLLKSG 528
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 486 LQKDLDALGFNLVGFGCTTCIGNSGPLPAPISKTINEKGLIAAAVLSGNRNFEGRVSPDVQANYLASPPLVVAHALAGTV 565
Cdd:PLN00070 529 LQKYLNQQGFHIVGYGCTTCIGNSGELDESVASAITENDIVAAAVLSGNRNFEGRVHPLTRANYLASPPLVVAYALAGTV 608
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 566 TKDLTKEPLGEDQNGNPVFLRDIWPSSQEIQEFIAKNVTRKIFSEKYADVFKGDENWQAVQVPAGQTYAWDDNSTYVQNP 645
Cdd:PLN00070 609 DIDFEKEPIGTGKDGKDVFFRDIWPSNEEVAEVVQSSVLPDMFKSTYEAITKGNPMWNQLSVPSGTLYSWDPKSTYIHEP 688
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 646 PYFVGMGKSAGTIGDVKGARILGLFGDKITTDHISPAGSIKAQSPAGKYLIDHGVGIADFNQYGTRRGNHEVMMRGTFAN 725
Cdd:PLN00070 689 PYFKNMTMSPPGPHGVKDAYCLLNFGDSITTDHISPAGSIHKDSPAAKYLMERGVDRKDFNSYGSRRGNDEIMARGTFAN 768
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 726 IRIRNHMLgeNGREGGYTIHYPSKEETSIYDAAMQYKAEGVPLVVFAGVEYGNGSSRDWAAKGTNLLGVKAVIAQSFERI 805
Cdd:PLN00070 769 IRIVNKLL--KGEVGPKTVHIPTGEKLSVFDAAMKYKSEGHDTIILAGAEYGSGSSRDWAAKGPMLLGVKAVIAKSFERI 846
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 806 HRSNLVGMGIVPFVFEEGTSWQTLGLKGDEMVTIE---GLADVRPRQkvDASITFADGtvKKVPLICRIDTLDELDYMKN 882
Cdd:PLN00070 847 HRSNLVGMGIIPLCFKSGEDADTLGLTGHERYTIDlpsNISEIKPGQ--DVTVTTDNG--KSFTCTLRFDTEVELAYFDH 922
                        890
                 ....*....|...
gi 500733028 883 GGILQTVLRDLAA 895
Cdd:PLN00070 923 GGILPYVIRNLIK 935
AcnA_IRP cd01586
Aconitase A catalytic domain; Aconitase A catalytic domain. This is the major form of the TCA ...
87-565 0e+00

Aconitase A catalytic domain; Aconitase A catalytic domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydrolyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group also includes sequences that have been shown to act as an iron-responsive element (IRE) binding protein in animals and may have the same role in other eukaryotes.


Pssm-ID: 153136  Cd Length: 404  Bit Score: 749.90  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028  87 RVLMQDFTGVPAVVDLAAMRDGLKALGGDPEKINPLVPVDLVIDHSVIVDEFGNPSAFKANVDLEYQRNGERYRFLKWGQ 166
Cdd:cd01586    1 RVILQDFTGVPAVVDLAAMRDAVKRLGGDPEKINPLIPVDLVIDHSVQVDFYGTADALAKNMKLEFERNRERYEFLKWGQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 167 QAFKNFRVVPPGTGICHQVNLEYLAQAVWTKEEDGETVAYPDTCVGTDSHTTMVNGLGVLGWGVGGIEAEAAMLGQPVSM 246
Cdd:cd01586   81 KAFKNLRVVPPGTGIIHQVNLEYLARVVFTSEEDGDGVAYPDSVVGTDSHTTMINGLGVLGWGVGGIEAEAVMLGQPISM 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 247 LLPEVVGFRLTGKIKEGVTATDLVLTVTQMLRKKGVVGKFVEFFGEGLENMTLADRATIANMGPEYGATCGFFPVDretl 326
Cdd:cd01586  161 LLPEVVGVKLTGKLRPGVTATDLVLTVTQMLRKVGVVGKFVEFFGPGVAKLSVADRATIANMAPEYGATCGFFPVD---- 236
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 327 nymnttgrdehrielveaycraqgmwrdkgaadpvfTDILELDMSDVVPSMAGPKRPEGRIALeniasgfatsleneykk 406
Cdd:cd01586  237 ------------------------------------TQVVELDLSTVEPSVSGPKRPQDRVPL----------------- 263
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 407 ttgqtaryavegedydlgHGDVAIAAITSCTNTSNPSVLIAAGLLARNAVAKGLKTKPWVKTSLAPGSQVVAAYLESAGL 486
Cdd:cd01586  264 ------------------HGSVVIAAITSCTNTSNPSVMLAAGLLAKKAVELGLKVKPYVKTSLAPGSRVVTKYLEASGL 325
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 500733028 487 QKDLDALGFNLVGFGCTTCIGNSGPLPAPISKTINEKGLIAAAVLSGNRNFEGRVSPDVQANYLASPPLVVAHALAGTV 565
Cdd:cd01586  326 LPYLEKLGFHVVGYGCTTCIGNSGPLPEEVEEAIKENDLVVAAVLSGNRNFEGRIHPLVRANYLASPPLVVAYALAGTV 404
Aconitase pfam00330
Aconitase family (aconitate hydratase);
80-563 0e+00

Aconitase family (aconitate hydratase);


Pssm-ID: 459764  Cd Length: 460  Bit Score: 647.56  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028   80 EIAYRPARVLMQDFTGVPAVVDLAAMRDGLKALGGDPEKINPLVPVDLVIDHSvivdefgnPSAFKANVDLEYQRNGERY 159
Cdd:pfam00330  15 SLLYIPDRVLMHDVTSPQAFVDLRAAGRAVRRPGGTPATIDHLVPTDLVIDHA--------PDALDKNIEDEISRNKEQY 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028  160 RFLKWGQQAFkNFRVVPPGTGICHQVNLEYLaqavwtkeedgetVAYPD-TCVGTDSHTTMVNGLGVLGWGVGGIEAEAA 238
Cdd:pfam00330  87 DFLEWNAKKF-GIRFVPPGQGIVHQVGLEYG-------------LALPGmTIVGTDSHTTTHGGLGALAFGVGGSEAEHV 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028  239 MLGQPVSMLLPEVVGFRLTGKIKEGVTATDLVLTVTQMLRKKGVVGKFVEFFGEGLENMTLADRATIANMGPEYGATCGF 318
Cdd:pfam00330 153 LATQPLEMKKPKVVGVKLTGKLPPGVTAKDVILAIIGKLGVKGGTGKVVEFFGPGVRSLSMEGRATICNMAIEYGATAGL 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028  319 FPVDRETLNYMNTTGRDEHRIelVEAYCRAQGMWRDKGAADPVFTDILELDMSDVVPSMAGPKRPEGRIAL-ENIASGFA 397
Cdd:pfam00330 233 FPPDETTFEYLRATGRPEAPK--GEAYDKAVAWKTLASDPGAEYDKVVEIDLSTIEPMVTGPTRPQDAVPLsELVPDPFA 310
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028  398 TSLENEYKKttgQTARYAVEGEDYDLGHGDVAIAAITSCTNTSNPSVLIAAGLLArNAVAKGLKTKPWVKTSLAPGSQVV 477
Cdd:pfam00330 311 DAVKRKAAE---RALEYMGLGPGTPLSDGKVDIAFIGSCTNSSIEDLRAAAGLLK-KAVEKGLKVAPGVKASVVPGSEVV 386
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028  478 AAYLESAGLQKDLDALGFNLVGFGCTTCIGNSGPLPApisktiNEkgliaAAVLSGNRNFEGRVSPDVQAnYLASPPLVV 557
Cdd:pfam00330 387 RAYAEAEGLDKILEEAGFEWRGPGCSMCIGNSDRLPP------GE-----RCVSSSNRNFEGRQGPGGRT-HLASPALVA 454

                  ....*.
gi 500733028  558 AHALAG 563
Cdd:pfam00330 455 AAAIAG 460
AcnA_IRP_Swivel cd01580
Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, ...
669-841 6.34e-103

Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group also includes sequences that have been shown to act as an iron-responsive element (IRE) binding protein in animals and may have the same role in other eukaryotes. This is the aconitase-like swivel domain, which is believed to undergo swivelling conformational change in the enzyme mechanism.


Pssm-ID: 238812 [Multi-domain]  Cd Length: 171  Bit Score: 316.53  E-value: 6.34e-103
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 669 LFGDKITTDHISPAGSIKAQSPAGKYLIDHGVGIADFNQYGTRRGNHEVMMRGTFANIRIRNHMLGenGREGGYTIHYPS 748
Cdd:cd01580    1 LLGDSVTTDHISPAGSIAKDSPAGKYLAERGVKPRDFNSYGSRRGNDEVMMRGTFANIRLRNKLVP--GTEGGTTHHPPT 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 749 KEETSIYDAAMQYKAEGVPLVVFAGVEYGNGSSRDWAAKGTNLLGVKAVIAQSFERIHRSNLVGMGIVPFVFEEGTSWQT 828
Cdd:cd01580   79 GEVMSIYDAAMRYKEEGVPLVILAGKEYGSGSSRDWAAKGPFLLGVKAVIAESFERIHRSNLVGMGILPLQFPPGENADS 158
                        170
                 ....*....|...
gi 500733028 829 LGLKGDEMVTIEG 841
Cdd:cd01580  159 LGLTGEETYDIIG 171
PRK07229 PRK07229
aconitate hydratase; Validated
77-895 1.94e-86

aconitate hydratase; Validated


Pssm-ID: 235974 [Multi-domain]  Cd Length: 646  Bit Score: 289.35  E-value: 1.94e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028  77 AGAEIAYRPARVLMQDFTGVPAVVDLAAMrdGLkalggdpekinPLVPVDLV---IDHSVIVDEFGNPsafkanvdleyq 153
Cdd:PRK07229  21 PGEEIAIRIDQTLTQDATGTMAYLQFEAM--GL-----------DRVKTELSvqyVDHNLLQADFENA------------ 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 154 rngERYRFLkwgQQAFKNFRVV--PPGTGICHQVNLE-YlaqavwtkeedgetvAYP-DTCVGTDSHTT------MVngl 223
Cdd:PRK07229  76 ---DDHRFL---QSVAAKYGIYfsKPGNGICHQVHLErF---------------AFPgKTLLGSDSHTPtagglgML--- 131
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 224 gvlgwgvgGI-----EAEAAMLGQPVSMLLPEVVGFRLTGKIKEGVTATDLVLTVTQMLRKKGVVGKFVEFFGEGLENMT 298
Cdd:PRK07229 132 --------AIgagglDVALAMAGGPYYLKMPKVVGVKLTGKLPPWVSAKDVILELLRRLTVKGGVGKIIEYFGPGVATLS 203
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 299 LADRATIANMGPEYGATCGFFPVDRETLNYMNTTGRDEHRIELveaycraqgmwrdkgAADP--VFTDILELDMSDVVPS 376
Cdd:PRK07229 204 VPERATITNMGAELGATTSIFPSDERTREFLKAQGREDDWVEL---------------LADPdaEYDEVIEIDLSELEPL 268
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 377 MAGPKRPegrialeniasGFATSLENeykkttgqtaryaVEGEdydlghgDVAIAAITSCTNTSNPSVLIAAgllarnAV 456
Cdd:PRK07229 269 IAGPHSP-----------DNVVPVSE-------------VAGI-------KVDQVLIGSCTNSSYEDLMRAA------SI 311
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 457 AKGLKTKPWVKTSLAPGSQVVAAYLESAGLQKDLDALGFNLVGFGCTTCIGNSGplpAPISKTInekgliaaAVLSGNRN 536
Cdd:PRK07229 312 LKGKKVHPKVSLVINPGSRQVLEMLARDGALADLIAAGARILENACGPCIGMGQ---APATGNV--------SLRTFNRN 380
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 537 FEGRV-SPDVQAnYLASPPLVVAHALAGTVT--KDLTKEpLGEdqngnpvflrdiWPSSQEIQEFIAKNvtrkifsekyA 613
Cdd:PRK07229 381 FPGRSgTKDAQV-YLASPETAAASALTGVITdpRTLALE-NGE------------YPKLEEPEGFAVDD----------A 436
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 614 DVFKGDENWQAVQVPAGQtyawddNSTYVQ-NPPyfvgmgksagtIGDVKGARILGLFGDKITTDHISPAGSikaqspag 692
Cdd:PRK07229 437 GIIAPAEDGSDVEVVRGP------NIKPLPlLEP-----------LPDLLEGKVLLKVGDNITTDHIMPAGA-------- 491
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 693 KYLidhgvgiadfnqygtrrgnhevMMRGtfaNI-RIRNHMLgengreggytihypskeetSIYDAAMQYKA-EGVPLVV 770
Cdd:PRK07229 492 KWL----------------------PYRS---NIpNISEFVF-------------------EGVDNTFPERAkEQGGGIV 527
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 771 FAGVEYGNGSSRDWAAKGTNLLGVKAVIAQSFERIHRSNLVGMGIVPFVFEEGTSWQTLGLkGDEmVTIEGLADVRPRQK 850
Cdd:PRK07229 528 VGGENYGQGSSREHAALAPRYLGVKAVLAKSFARIHKANLINFGILPLTFADPADYDKIEE-GDV-LEIEDLREFLPGGP 605
                        810       820       830       840
                 ....*....|....*....|....*....|....*....|....*.
gi 500733028 851 VDASITFADGTVKkvpliCRID-TLDELDYMKNGGILQTVLRDLAA 895
Cdd:PRK07229 606 LTVVNVTKDEEIE-----VRHTlSERQIEILLAGGALNLIKKKLAA 646
Aconitase cd01351
Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and ...
87-565 1.37e-81

Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Aconitase catalytic domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. Cis-aconitate is formed as an intermediate product during the course of the reaction. In eukaryotes two isozymes of aconitase are known to exist: one found in the mitochondrial matrix and the other found in the cytoplasm. Aconitase, in its active form, contains a 4Fe-4S iron-sulfur cluster; three cysteine residues have been shown to be ligands of the 4Fe-4S cluster. This is the Aconitase core domain, including structural domains 1, 2 and 3, which binds the Fe-S cluster. The aconitase family also contains the following proteins: - Iron-responsive element binding protein (IRE-BP), a cytosolic protein that binds to iron-responsive elements (IREs). IREs are stem-loop structures found in the 5'UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'UTR of transferrin receptor mRNA. IRE-BP also express aconitase activity. - 3-isopropylmalate dehydratase (isopropylmalate isomerase), the enzyme that catalyzes the second step in the biosynthesis of leucine. - Homoaconitase (homoaconitate hydratase), an enzyme that participates in the alpha-aminoadipate pathway of lysine biosynthesis and that converts cis-homoaconitate into homoisocitric acid.


Pssm-ID: 153129 [Multi-domain]  Cd Length: 389  Bit Score: 268.21  E-value: 1.37e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028  87 RVLMQDFTGVPAVVDLAAMrdglkalgGDPEKINPLVPVDLVIDHSVivdefgnpsafkanvDLEYQRNGERYRFLKWGQ 166
Cdd:cd01351    1 RVMLQDATGPMAMKAFEIL--------AALGKVADPSQIACVHDHAV---------------QLEKPVNNEGHKFLSFFA 57
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 167 QAFKnFRVVPPGTGICHQVNLEYLAQavwtkeedgetvaYPDTCVGTDSHTTMVNGLGVLGWGVGGIEAEAAMLGQPVSM 246
Cdd:cd01351   58 ALQG-IAFYRPGVGIIHQIMVENLAL-------------PGDLLVGSDSHTTSYGGLGAISTGAGGGDVAFVMAGGPAWL 123
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 247 LLPEVVGFRLTGKIKEGVTATDLVLTVTQMLRKKGVVGKFVEFFGEGLENMTLADRATIANMGPEYGATCGFFPVDRETL 326
Cdd:cd01351  124 KKPEVVGVNLTGKLSPGVTGKDVVLKLGGIVGVDGVLNRIVEFYGEGVSSLSIEDRLTICNMMAELGATTGIFPEDKTTL 203
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 327 NYMNTTGrdehrielveaycRAQGMWRDKGAADPVFTD-------ILELDMSDVVPSMAGPKRPEGRIALEniasgfats 399
Cdd:cd01351  204 KWLEATG-------------RPLLKNLWLAFPEELLADegaeydqVIEIDLSELEPDISGPNRPDDAVSVS--------- 261
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 400 leneykkttgqtaryavegedyDLGHGDVAIAAITSCTNtSNPSVLIAAGllarnAVAKGLKTKPWVKTSLAPGSQVVAA 479
Cdd:cd01351  262 ----------------------EVEGTKIDQVLIGSCTN-NRYSDMLAAA-----KLLKGAKVAPGVRLIVTPGSRMVYA 313
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 480 YLESAGLQKDLDALGFNLVGFGCTTCIGNSGPLPAPISKtinekgliaaAVLSGNRNFEGRVSPDVQANYLASPPLVVAH 559
Cdd:cd01351  314 TLSREGYYEILVDSGARILPPGCGPCMGNGARLVADGEV----------GVSSGNRNFPGRLGTYERHVYLASPELAAAT 383

                 ....*.
gi 500733028 560 ALAGTV 565
Cdd:cd01351  384 AIAGKI 389
AcnA_Bact cd01585
Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA ...
89-565 2.42e-50

Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Bacterial Aconitase-like catalytic domain. Aconitase (aconitate hydratase or citrate hydrolyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. Cis-aconitate is formed as an intermediate product during the course of the reaction. This distinct subfamily is found only in bacteria and Archaea. Its exact characteristics are not known.


Pssm-ID: 153135  Cd Length: 380  Bit Score: 182.26  E-value: 2.42e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028  89 LMQDFTGVPAVVDLAAMrdglkalgGDPEkinplVPVDLV---IDHSVIVDEFgnpsafkanvdleyqRNGERYRFLkwg 165
Cdd:cd01585    4 LTQDATGTMAYLQFEAM--------GVDR-----VRTELSvsyVDHNTLQTDF---------------ENADDHRFL--- 52
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 166 QQAFKNFRVV--PPGTGICHQVNLEYLAQAvwtkeedGETVaypdtcVGTDSHTTMVNGLGVLGWGVGGIEAEAAMLGQP 243
Cdd:cd01585   53 QTVAARYGIYfsRPGNGICHQVHLERFAVP-------GKTL------LGSDSHTPTAGGLGMLAIGAGGLDVALAMAGEP 119
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 244 VSMLLPEVVGFRLTGKIKEGVTATDLVLTVTQMLRKKGVVGKFVEFFGEGLENMTLADRATIANMGPEYGATCGFFPVDR 323
Cdd:cd01585  120 YYIPMPKVVGVRLTGELPPWVTAKDVILELLRRLTVKGGVGKIFEYTGPGVATLSVPERATITNMGAELGATTSIFPSDE 199
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 324 ETLNYMNTTGRDEHRIELveaycraqgmwrdkgAADP--VFTDILELDMSDVVPSMAGPKRPEGRIALENIAsgfatsle 401
Cdd:cd01585  200 RTREFLAAQGREDDWVEL---------------AADAdaEYDEEIEIDLSELEPLIARPHSPDNVVPVREVA-------- 256
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 402 neykkttGQtaryavegedydlghgDVAIAAITSCTNTSNPSVLIAAGLLarnavaKGLKTKPWVKTSLAPGSQVVAAYL 481
Cdd:cd01585  257 -------GI----------------KVDQVAIGSCTNSSYEDLMTVAAIL------KGRRVHPHVSMVVAPGSKQVLEML 307
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 482 ESAGLQKDLDALGFNLVGFGCTTCIGNSGplpAPISKTInekgliaaAVLSGNRNFEGRVSPDVQANYLASPPLVVAHAL 561
Cdd:cd01585  308 ARNGALADLLAAGARILESACGPCIGMGQ---APPTGGV--------SVRTFNRNFEGRSGTKDDLVYLASPEVAAAAAL 376

                 ....
gi 500733028 562 AGTV 565
Cdd:cd01585  377 TGVI 380
LeuC COG0065
Homoaconitase/3-isopropylmalate dehydratase large subunit [Amino acid transport and metabolism] ...
87-566 2.59e-48

Homoaconitase/3-isopropylmalate dehydratase large subunit [Amino acid transport and metabolism]; Homoaconitase/3-isopropylmalate dehydratase large subunit is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis


Pssm-ID: 439835  Cd Length: 417  Bit Score: 177.14  E-value: 2.59e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028  87 RVLMQDFTGVPAVvdlaamrDGLKALGG----DPEKInplvpVdLVIDHSVivdeFGNPSAFKANVDlEYQRNGERY--R 160
Cdd:COG0065   30 LHLVHDVTSPQAF-------EGLREAGGrkvwDPDRI-----V-AVFDHNV----PTKDPKSAEQVK-TLREFAKEFgiT 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 161 FLKWGQQafknfrvvppgtGICHQVnleyLAQAVWTKeedgetvayP-DTCVGTDSHTTM----------VNGLgvlgwg 229
Cdd:COG0065   92 FFDVGDP------------GICHVV----LPEQGLVL---------PgMTIVGGDSHTCThgafgafafgIGTT------ 140
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 230 vggiEAEAAMLGQPVSMLLPEVVGFRLTGKIKEGVTATDLVLTVTQMLRKKGVVGKFVEFFGEGLENMTLADRATIANMG 309
Cdd:COG0065  141 ----DVAHVLATGTLWFKVPETMRIEVTGKLPPGVTAKDLILAIIGKIGADGATGKAIEFAGEAIRALSMEERMTLCNMA 216
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 310 PEYGATCGFFPVDRETLNYMNttGRDEHRIELVEAycraqgmwrDKGAadpVFTDILELDMSDVVPSMAGPKRPEGRIAL 389
Cdd:COG0065  217 IEAGAKAGIIAPDETTFEYLK--GRPFAPWRTLKS---------DEDA---VYDKEVEIDASDLEPQVAWPHSPDNVVPV 282
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 390 ENIAsgfatsleneykkttgqtaryavegedydlghgDVAI--AAITSCTNtsnpSVL----IAAgllarnAVAKGLKTK 463
Cdd:COG0065  283 SELE---------------------------------GIKIdqVFIGSCTN----GRIedlrAAA------EILKGRKVA 319
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 464 PWVKTSLAPGSQVVAAYLESAGLQKDLDALGFNLVGFGCTTCIG-NSGPLPApisktiNEKgliaaAVLSGNRNFEGRV- 541
Cdd:COG0065  320 PGVRAIVVPGSQEVYRQAEAEGLDEIFIEAGAEWREPGCGMCLGmNMGVLAP------GER-----CASTSNRNFEGRMg 388
                        490       500
                 ....*....|....*....|....*
gi 500733028 542 SPDVQAnYLASPPLVVAHALAGTVT 566
Cdd:COG0065  389 SPGSRT-YLASPATAAASAIAGRIT 412
AcnA_Mitochondrial cd01584
Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA ...
87-564 2.28e-46

Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Mitochondrial aconitase A catalytic domain. Aconitase (also known as aconitate hydratase and citrate hydro-lyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. Cis-aconitate is formed as an intermediary product during the course of the reaction. In eukaryotes two isozymes of aconitase are known to exist: one found in the mitochondrial matrix and the other found in the cytoplasm. This is the mitochondrial form. The mitochondrial product is coded by a nuclear gene. Most members of this subfamily are mitochondrial but there are some bacterial members.


Pssm-ID: 153134  Cd Length: 412  Bit Score: 171.47  E-value: 2.28e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028  87 RVLMQDFTGVPAVvdLAAMRDGLKalggdpekiNPLVPVDLVIDHsVIVDEFGNPSAFKANVDLeyqrNGERYRFL---- 162
Cdd:cd01584    1 RVAMQDATAQMAL--LQFMSSGLP---------KVAVPSTIHCDH-LIEAQVGGEKDLKRAKDI----NKEVYDFLasag 64
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 163 -KWGQQAFKnfrvvpPGTGICHQVNLEylaqavwtkeedgeTVAYPDTC-VGTDSHTTMVNGLGVLGWGVGGIEAEAAML 240
Cdd:cd01584   65 aKYGIGFWK------PGSGIIHQIVLE--------------NYAFPGLLmIGTDSHTPNAGGLGGIAIGVGGADAVDVMA 124
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 241 GQPVSMLLPEVVGFRLTGKIKEGVTATDLVLTVTQMLRKKGVVGKFVEFFGEGLENMTLADRATIANMGPEYGATCGFFP 320
Cdd:cd01584  125 GIPWELKCPKVIGVKLTGKLSGWTSPKDVILKVAGILTVKGGTGAIVEYFGPGVDSLSCTGMGTICNMGAEIGATTSVFP 204
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 321 VDRETLNYMNTTGRDEhrielVEAYcrAQGMWRDKGAADP--VFTDILELDMSDVVPSMAGPKRPEgrialeniasgFAT 398
Cdd:cd01584  205 YNERMKKYLKATGRAE-----IADL--ADEFKDDLLVADEgaEYDQLIEINLSELEPHINGPFTPD-----------LAT 266
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 399 SLeNEYKKTtgqtaryaVEGEDYDLghgDVAIAAITSCTNTSNPSVLIAAGlLARNAVAKGLKTKpwVKTSLAPGSQVVA 478
Cdd:cd01584  267 PV-SKFKEV--------AEKNGWPL---DLRVGLIGSCTNSSYEDMGRAAS-IAKQALAHGLKCK--SIFTITPGSEQIR 331
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 479 AYLESAGLQKDLDALGFNLVGFGCTTCIGNsgplpapISKTINEKGLIAAAVLSGNRNFEGRVSPDVQA-NYLASPPLVV 557
Cdd:cd01584  332 ATIERDGLLQTFRDAGGIVLANACGPCIGQ-------WDRKDIKKGEKNTIVTSYNRNFTGRNDANPAThAFVASPEIVT 404

                 ....*..
gi 500733028 558 AHALAGT 564
Cdd:cd01584  405 AMAIAGT 411
Aconitase_C pfam00694
Aconitase C-terminal domain; Members of this family usually also match to pfam00330. This ...
691-823 4.67e-46

Aconitase C-terminal domain; Members of this family usually also match to pfam00330. This domain undergoes conformational change in the enzyme mechanism.


Pssm-ID: 459908 [Multi-domain]  Cd Length: 131  Bit Score: 160.99  E-value: 4.67e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028  691 AGKYLIDHGVGIADFNQYGTRRGNHEVMMRGTFANIRIRNHMLgeNGREGGYTIHYPSKEETSIYDAAMQYKAEGVPLVV 770
Cdd:pfam00694   1 MPVFLKLKGKTTPDFNSNVDTDLIIPKQFLGTIANIGIGNINF--EGWRYGKVRYLPDGENPDFYDAAMRYKQHGAPIVV 78
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 500733028  771 FAGVEYGNGSSRDWAAKGTNLLGVKAVIAQSFERIHRSNLVGMGIVPFVFEEG 823
Cdd:pfam00694  79 IGGKNFGCGSSREHAAWALRDLGIKAVIAESFARIHRNNLIKNGLLPLEFPEE 131
IPMI cd01583
3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and ...
87-565 1.13e-45

3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Aconatase-like catalytic domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate 3-isopropylmalate. IPMI is involved in fungal and bacterial leucine biosynthesis and is also found in eukaryotes.


Pssm-ID: 153133  Cd Length: 382  Bit Score: 168.91  E-value: 1.13e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028  87 RVLMQDFTGVPAVvdlaamrDGLKALGG----DPEKINplvpvdLVIDHSVIvdefgNPSAFKANVDLEYQRNGERyrfl 162
Cdd:cd01583    1 LHLVHDVTSPQAF-------EGLREAGRekvwDPEKIV------AVFDHNVP-----TPDIKAAEQVKTLRKFAKE---- 58
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 163 kwgqQAFKNFRVVppGTGICHQVnleyLAQAVWTKEedGETVaypdtcVGTDSHTTMVNGLGVLGWGVGGIEAEAAMLGQ 242
Cdd:cd01583   59 ----FGINFFDVG--RQGICHVI----LPEKGLTLP--GMTI------VGGDSHTCTHGAFGAFATGIGTTDVAHVLATG 120
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 243 PVSMLLPEVVGFRLTGKIKEGVTATDLVLTVTQMLRKKGVVGKFVEFFGEGLENMTLADRATIANMGPEYGATCGFFPVD 322
Cdd:cd01583  121 KLWFRVPETMRVNVEGKLPPGVTAKDVILYIIGKIGVDGATYKAMEFAGEAIESLSMEERMTLCNMAIEAGAKAGIVAPD 200
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 323 RETLNYMNTTGRDEHRIelveaycraqgmWR-DKGAadpVFTDILELDMSDVVPSMAGPKRPEGRIALENiasgfatsle 401
Cdd:cd01583  201 ETTFEYLKGRGKAYWKE------------LKsDEDA---EYDKVVEIDASELEPQVAWPHSPDNVVPVSE---------- 255
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 402 neykkttgqtaryaVEGEDYDlghgdvaIAAITSCTNTSNPSVLIAAgllarnAVAKGLKTKPWVKTSLAPGSQVVAAYL 481
Cdd:cd01583  256 --------------VEGIKID-------QVFIGSCTNGRLEDLRAAA------EILKGRKVADGVRLIVVPASQRVYKQA 308
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 482 ESAGLQKDLDALGFNLVGFGCTTCIG-NSGPLPapisktineKGLIAAAvlSGNRNFEGRVSPDVQANYLASPPLVVAHA 560
Cdd:cd01583  309 EKEGLIEIFIEAGAEVRPPGCGACLGgHMGVLA---------PGERCVS--TSNRNFKGRMGSPGARIYLASPATAAASA 377

                 ....*
gi 500733028 561 LAGTV 565
Cdd:cd01583  378 ITGEI 382
PRK00402 PRK00402
3-isopropylmalate dehydratase large subunit; Reviewed
96-566 2.64e-38

3-isopropylmalate dehydratase large subunit; Reviewed


Pssm-ID: 234748  Cd Length: 418  Bit Score: 148.40  E-value: 2.64e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028  96 VPAVVDLAAMRDG--------LKALGG----DPEKINplvpvdLVIDHSVivdefgnPSAfkaNVDLEyqrngERYRFL- 162
Cdd:PRK00402  24 VEAKVDLVMAHDItgplaikeFEKIGGdkvfDPSKIV------IVFDHFV-------PAK---DIKSA-----EQQKILr 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 163 KWG-QQAFKNFRVVppGTGICHQVNLEylaqavwtkeedgETVAYP-DTCVGTDSHTT----------------Mvnglg 224
Cdd:PRK00402  83 EFAkEQGIPNFFDV--GEGICHQVLPE-------------KGLVRPgDVVVGADSHTCtygalgafatgmgstdM----- 142
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 225 vlgwgvggieAEAAMLGQpVSMLLPEVVGFRLTGKIKEGVTATDLVLTVTQMLRKKGVVGKFVEFFGEGLENMTLADRAT 304
Cdd:PRK00402 143 ----------AAAMATGK-TWFKVPETIKVVLEGKLPPGVTAKDVILHIIGDIGVDGATYKALEFTGETIEALSMDERMT 211
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 305 IANMGPEYGATCGFFPVDRETLNYMNTTGRDEHRIelveaycraqgMWRDKGAadpVFTDILELDMSDVVPSMAGPKRPe 384
Cdd:PRK00402 212 LANMAIEAGAKAGIFAPDEKTLEYLKERAGRDYKP-----------WKSDEDA---EYEEVYEIDLSKLEPQVAAPHLP- 276
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 385 grialENIasgfatsleneykKTTGQtaryaVEGEDYDlghgdvaIAAITSCTNTSNPSVLIAAGLLarnavaKGLKTKP 464
Cdd:PRK00402 277 -----DNV-------------KPVSE-----VEGTKVD-------QVFIGSCTNGRLEDLRIAAEIL------KGRKVAP 320
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 465 WVKTSLAPGSQVVAAYLESAGLQKDLDALGFNLVGFGCTTCIGNSGplpapisktinekGLIAA---AVLSGNRNFEGRV 541
Cdd:PRK00402 321 GVRLIVIPASQKIYLQALKEGLIEIFVDAGAVVSTPTCGPCLGGHM-------------GVLAPgevCLSTTNRNFKGRM 387
                        490       500
                 ....*....|....*....|....*.
gi 500733028 542 -SPDVQAnYLASPPLVVAHALAGTVT 566
Cdd:PRK00402 388 gSPESEV-YLASPAVAAASAVTGKIT 412
IPMI_arch TIGR02086
3-isopropylmalate dehydratase, large subunit; This subfamily is a subset of the larger HacA ...
77-566 1.96e-35

3-isopropylmalate dehydratase, large subunit; This subfamily is a subset of the larger HacA family (Homoaconitate hydratase family, TIGR01343) and is most closely related to the 3-isopropylmalate dehydratase, large subunits which form TIGR00170. This subfamily includes the members of TIGR01343 which are gene clustered with other genes of leucine biosynthesis. The rest of the subfamily includes mainly archaeal species which exhibit two hits to this model. In these cases it is possible that one or the other of the hits does not have a 3-isopropylmalate dehydratase activity but rather one of the other related aconitase-like activities.


Pssm-ID: 273960  Cd Length: 413  Bit Score: 139.90  E-value: 1.96e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028   77 AGAEIAYRPARVLMQDFTGVPAvvdLAAMRDGLKALGGDPEKINplvpvdLVIDHSVivdefgNPSAFKANvdlEYQRng 156
Cdd:TIGR02086  18 AGEIVEVEVDLAMTHDGTGPLA---IKALRELGVARVWDPEKIV------IAFDHNV------PPPTVEAA---EMQK-- 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028  157 ERYRFLKwgQQAFKNFRVvppGTGICHQVNLEylaqavwtkeedgETVAYP-DTCVGTDSHTTMVNGLGVLGWGVGGIE- 234
Cdd:TIGR02086  78 EIREFAK--RHGIKNFDV---GEGICHQILAE-------------EGYALPgMVVVGGDSHTCTSGAFGAFATGMGATDm 139
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028  235 AEAAMLGQPVSMlLPEVVGFRLTGKIKEGVTATDLVLTVTQMLRKKGVVGKFVEFFGEGLENMTLADRATIANMGPEYGA 314
Cdd:TIGR02086 140 AIALATGKTWIK-VPETIRVVVEGKPEEGVTAKDVALHIVGELGADGATYMAIEFFGLPIENMDMDGRLTLCNMAVEMGA 218
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028  315 TCGFFPVDRETLNYMNTTGRDEHRIelveaycraqgMWRDKGAadpVFTDILELDMSDVVPSMAGPKRPegrialENIas 394
Cdd:TIGR02086 219 KAGIIEPDEETYEYLKKRRGLEFRI-----------LVPDPGA---NYYKEIEIDLSDLEPQVAVPHSV------DNV-- 276
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028  395 gfatsleneykKTTGQtaryaVEGEDYDLghgdvaiAAITSCTNTSNPSVLIAAGLLarnavaKGLKTKPWVKTSLAPGS 474
Cdd:TIGR02086 277 -----------KPVSD-----VEGTEIDQ-------VFIGSCTNGRLEDLRIAAEIL------KGRRVHPDVRLIVIPAS 327
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028  475 QVVAAYLESAGLQKDLDALGFNLVGFGCTTCIGNSGPLPAPisktiNEkgliaAAVLSGNRNFEGRV-SPDVQAnYLASP 553
Cdd:TIGR02086 328 RKVYLRALEEGIILTLVRAGAMICPPGCGPCLGAHMGVLGD-----GE-----VCLSTTNRNFKGRMgSPNAEI-YLASP 396
                         490
                  ....*....|...
gi 500733028  554 PLVVAHALAGTVT 566
Cdd:TIGR02086 397 ATAAASAVEGYIT 409
hacA_fam TIGR01343
homoaconitate hydratase family protein; This model represents a subfamily of proteins ...
96-566 2.14e-31

homoaconitate hydratase family protein; This model represents a subfamily of proteins consisting of aconitase, homoaconitase, 3-isopropylmalate dehydratase, and uncharacterized proteins. The majority of the members of this family have been designated as 3-isopropylmalate dehydratase large subunit (LeuC) in microbial genome annotation, but the only characterized member is Thermus thermophilus homoaconitase, an enzyme of a non-aspartate pathway of Lys biosynthesis.


Pssm-ID: 273563  Cd Length: 412  Bit Score: 127.95  E-value: 2.14e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028   96 VPAVVDLAAMRDG--------LKALGGD----PEKINplvpvdLVIDHSVivdefgNPSAFKANvdleyQRNGERYRFLK 163
Cdd:TIGR01343  21 IEAEIDLAMVHDItaplaiktLEEYGIDkvwnPEKIV------IVFDHQV------PADTIKAA-----EMQKLAREFVK 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028  164 wgQQAFKNFRvvPPGTGICHQVNLEylaqavwtkeedgETVAYP-DTCVGTDSHTTMVNGLGVLGWGVGGIEAEAAMLGQ 242
Cdd:TIGR01343  84 --KQGIKYFY--DVGEGICHQVLPE-------------KGLVKPgDLVVGADSHTCTYGAFGAFATGMGSTDMAYAIATG 146
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028  243 PVSMLLPEVVGFRLTGKIKEGVTATDLVLTVTQMLRKKGVVGKFVEFFGEGLENMTLADRATIANMGPEYGATCGFFPVD 322
Cdd:TIGR01343 147 KTWFKVPETIRVNITGKLNPGVTAKDVILEVIGEIGVDGATYMAMEFGGETVKNMDMEGRLTLANMAIEAGGKTGIIEPD 226
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028  323 RETLNYMNTTGRDEHRIElveaycraqgmwrdKGAADPVFTDILELDMSDVVPSMAGPKRPegrialENIAsgfatslen 402
Cdd:TIGR01343 227 EKTIQYLKERRKEPFRVY--------------KSDEDAEYAKEIEIDASQIEPVVACPHNV------DNVK--------- 277
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028  403 eykkttgqtaryavegEDYDLGHGDVAIAAITSCTNTSNPSVLIAAGLLarnavaKGLKTKPWVKTSLAPGSQVVaaYLE 482
Cdd:TIGR01343 278 ----------------PVSEVEGTEIDQVFIGSCTNGRLEDLRVAAKIL------KGRKVAPDVRLIVIPASRAV--YLQ 333
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028  483 SA--GLQKDLDALGFNLVGFGCTTCIGNSGPLPAPISKTINekgliaaavlSGNRNFEGRV-SPDVQAnYLASPPLVVAH 559
Cdd:TIGR01343 334 ALkeGLIEIFVKAGAVVSTPGCGPCLGSHQGVLAPGEVCIS----------TSNRNFKGRMgHPNAEI-YLASPATAAAS 402

                  ....*..
gi 500733028  560 ALAGTVT 566
Cdd:TIGR01343 403 AVKGYIA 409
PRK12466 PRK12466
3-isopropylmalate dehydratase large subunit;
214-566 5.95e-24

3-isopropylmalate dehydratase large subunit;


Pssm-ID: 183543  Cd Length: 471  Bit Score: 106.14  E-value: 5.95e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 214 DSHTTMVNGLGVLGWGVGGIEAEAAMLGQPVSMLLPEVVGFRLTGKIKEGVTATDLVLTVTQMLRKKGVVGKFVEFFGEG 293
Cdd:PRK12466 130 DSHTTTYGALGALAFGIGTSEVEHVLATQTLVYRKPKTMRVRVDGELPPGVTAKDLILALIARIGADGATGYAIEFAGEA 209
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 294 LENMTLADRATIANMGPEYGATCGFFPVDRETLNYMNTTGRDEHrielVEAYCRAQGMWRD-KGAADPVFTDILELDMSD 372
Cdd:PRK12466 210 IRALSMEGRMTLCNMAVEAGARGGLIAPDETTFDYLRGRPRAPK----GALWDAALAYWRTlRSDADAVFDREVEIDAAD 285
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 373 VVPSMAGPKRPEGRIALeniaSGFATSLENEYKKTTGQTARYAVegeDY-DLGHG----DVAI--AAITSCTNtSNPSVL 445
Cdd:PRK12466 286 IAPQVTWGTSPDQAVPI----TGRVPDPAAEADPARRAAMERAL---DYmGLTPGtplaGIPIdrVFIGSCTN-GRIEDL 357
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 446 IAAGllarnAVAKGLKTKPWVKTSLAPGSQVVAAYLESAGLQKDLDALGFNLVGFGCTTCIGNSGPLPAPisktinekGL 525
Cdd:PRK12466 358 RAAA-----AVLRGRKVAPGVRAMVVPGSGAVRRQAEAEGLARIFIAAGFEWREPGCSMCLAMNDDVLAP--------GE 424
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|.
gi 500733028 526 IAAAvlSGNRNFEGRVSPDVQAnYLASPPLVVAHALAGTVT 566
Cdd:PRK12466 425 RCAS--TTNRNFEGRQGPGART-HLMSPAMVAAAAVAGHIT 462
PRK05478 PRK05478
3-isopropylmalate dehydratase large subunit;
255-566 1.02e-23

3-isopropylmalate dehydratase large subunit;


Pssm-ID: 235490  Cd Length: 466  Bit Score: 105.59  E-value: 1.02e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 255 RLTGKIKEGVTATDLVLTVTQMLRKKGVVGKFVEFFGEGLENMTLADRATIANMGPEYGATCGFFPVDRETLNYMNttGR 334
Cdd:PRK05478 169 EVDGKLPPGVTAKDIILAIIGKIGTAGGTGYVIEFAGEAIRALSMEGRMTICNMSIEAGARAGLVAPDETTFEYLK--GR 246
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 335 dehriELV---EAYCRAQGMWR----DKGAadpVFTDILELDMSDVVPSMAGPKRPEGRIALeniaSGFATSLENEYKKT 407
Cdd:PRK05478 247 -----PFApkgEDWDKAVAYWKtlksDEDA---VFDKVVTLDAADIEPQVTWGTNPGQVISI----DGKVPDPEDFADPV 314
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 408 TGQTARYAVEgedY-DLGHG----DVAI--AAITSCTNtSNPSVLIAAGllarnAVAKGLKTKPWVKTSLAPGSQVVAAY 480
Cdd:PRK05478 315 KRASAERALA---YmGLKPGtpitDIKIdkVFIGSCTN-SRIEDLRAAA-----AVVKGRKVAPGVRALVVPGSGLVKAQ 385
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 481 LESAGLQKDLDALGFNLVGFGCTTCIG-NSGPLPApisktinekGLIAAAvlSGNRNFEGRvspdvQAN----YLASPPL 555
Cdd:PRK05478 386 AEAEGLDKIFIEAGFEWREPGCSMCLAmNPDKLPP---------GERCAS--TSNRNFEGR-----QGKggrtHLVSPAM 449
                        330
                 ....*....|.
gi 500733028 556 VVAHALAGTVT 566
Cdd:PRK05478 450 AAAAAITGHFV 460
Homoaconitase cd01582
Homoaconitase and other uncharacterized proteins of the Aconitase family; Homoaconitase ...
176-565 4.73e-23

Homoaconitase and other uncharacterized proteins of the Aconitase family; Homoaconitase catalytic domain. Homoaconitase and other uncharacterized proteins of the Aconitase family. Homoaconitase is part of an unusual lysine biosynthesis pathway found only in filamentous fungi, in which lysine is synthesized via the alpha-aminoadipate pathway. In this pathway, homoaconitase catalyzes the conversion of cis-homoaconitic acid into homoisocitric acid. The reaction mechanism is believed to be similar to that of other aconitases.


Pssm-ID: 153132 [Multi-domain]  Cd Length: 363  Bit Score: 101.92  E-value: 4.73e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 176 PPGTGICHQVNLEylaqavwtkeedgETVAYPDT-CVGTDSHTTMVNGLGVLGWGVGGIEAEAAMLGQPVSMLLPEVVGF 254
Cdd:cd01582   64 PAGRGIGHQIMIE-------------EGYAFPGTlAVASDSHSNMYGGVGCLGTPIVRTDAAAIWATGQTWWQIPPVAKV 130
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 255 RLTGKIKEGVTATDLVLTVTQMLRKKGVVGKFVEFFGEGLENMTLADRATIANMGPEYGATCGFFPVDRETLNymnttgr 334
Cdd:cd01582  131 ELKGQLPKGVTGKDVIVALCGLFNKDQVLNHAIEFTGSGLNSLSVDTRLTIANMTTEWGALSGLFPTDAKHLI------- 203
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 335 dehrielveaycraqgmwrdkgaadpvftdileLDMSDVVPSMAGPKrpegrialeniASGFATSLEneykkttgqtary 414
Cdd:cd01582  204 ---------------------------------LDLSTLSPYVSGPN-----------SVKVSTPLK------------- 226
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 415 avegedyDLGHGDVAI--AAITSCTNtSNPSVLIAAGLLARNAVAKGLKTK--PWVKTSLAPGSQVVAAYLESAGLQKDL 490
Cdd:cd01582  227 -------ELEAQNIKInkAYLVSCTN-SRASDIAAAADVVKGKKEKNGKIPvaPGVEFYVAAASSEVQAAAEKNGDWQTL 298
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 500733028 491 DALGFNLVGFGCTTCIGNSGPLPAPisktiNEKGLIAAavlsgNRNFEGRV-SPDVQAnYLASPPLVVAHALAGTV 565
Cdd:cd01582  299 LEAGATPLPAGCGPCIGLGQGLLEP-----GEVGISAT-----NRNFKGRMgSTEALA-YLASPAVVAASAISGKI 363
AcnA_Mitochon_Swivel cd01578
Mitochondrial aconitase A swivel domain. Aconitase (also known as aconitate hydratase and ...
673-847 7.98e-17

Mitochondrial aconitase A swivel domain. Aconitase (also known as aconitate hydratase and citrate hydro-lyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme mechanism. In eukaryotes two isozymes of aconitase are known to exist: one found in the mitochondrial matrix and the other found in the cytoplasm. This is the mitochondrial form. The mitochondrial product is coded by a nuclear gene. Most members of this subfamily are mitochondrial but there are some bacterial members.


Pssm-ID: 238810 [Multi-domain]  Cd Length: 149  Bit Score: 78.28  E-value: 7.98e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 673 KITTDHISPAGsikaqsPAGKYlidhgvgiadfnqygtrrgnhevmmRGTFANIRiRNHMLG----ENGrEGGYTIHYPS 748
Cdd:cd01578    5 KCTTDHISAAG------PWLKY-------------------------RGHLDNIS-NNLLIGainaENG-KANSVKNQVT 51
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 749 KEETSIYDAAMQYKAEGVPLVVFAGVEYGNGSSRDWAAKGTNLLGVKAVIAQSFERIHRSNLVGMGIVPFVFEEGTSWQT 828
Cdd:cd01578   52 GEYGPVPDTARDYKAHGIKWVVIGDENYGEGSSREHAALEPRHLGGRAIITKSFARIHETNLKKQGLLPLTFADPADYDK 131
                        170
                 ....*....|....*....
gi 500733028 829 lgLKGDEMVTIEGLADVRP 847
Cdd:cd01578  132 --IHPDDKVDILGLTDFAP 148
AcnA_Bact_Swivel cd01579
Bacterial Aconitase-like swivel domain. Aconitase (aconitate hydratase or citrate hydrolyase) ...
671-836 1.08e-16

Bacterial Aconitase-like swivel domain. Aconitase (aconitate hydratase or citrate hydrolyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. Cis-aconitate is formed as an intermediate product during the course of the reaction. This is the aconitase-like swivel domain, which is believed to undergo swivelling conformational change in the enzyme mechanism. This distinct subfamily is found only in bacteria and archea. Its exact characteristics are not known.


Pssm-ID: 238811 [Multi-domain]  Cd Length: 121  Bit Score: 77.09  E-value: 1.08e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 671 GDKITTDHISPAGSikaqspagKYLidhgvgiadfnqygTRRGNHEVMMRGTFanirirnHMLGENgreggytihYPSKE 750
Cdd:cd01579    3 GDNITTDHIMPAGA--------KVL--------------PLRSNIPAISEFVF-------HRVDPT---------FAERA 44
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 751 EtsiydaamqykaEGVPLVVFAGVEYGNGSSRDWAAKGTNLLGVKAVIAQSFERIHRSNLVGMGIVPFVFEEGTSWQTLG 830
Cdd:cd01579   45 K------------AAGPGFIVGGENYGQGSSREHAALAPMYLGVRAVLAKSFARIHRANLINFGILPLTFADEDDYDRFE 112

                 ....*.
gi 500733028 831 LkGDEM 836
Cdd:cd01579  113 Q-GDQL 117
Aconitase_swivel cd00404
Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible ...
767-836 1.45e-16

Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme mechanism. The aconitase family contains the following proteins: - Iron-responsive element binding protein (IRE-BP). IRE-BP is a cytosolic protein that binds to iron-responsive elements (IREs). IREs are stem-loop structures found in the 5'UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'UTR of transferrin receptor mRNA. IRE-BP also express aconitase activity. - 3-isopropylmalate dehydratase (isopropylmalate isomerase), the enzyme that catalyzes the second step in the biosynthesis of leucine. - Homoaconitase (homoaconitate hydratase), an enzyme that participates in the alpha-aminoadipate pathway of lysine biosynthesis and that converts cis-homoaconitate into homoisocitric acid.


Pssm-ID: 238236 [Multi-domain]  Cd Length: 88  Bit Score: 75.58  E-value: 1.45e-16
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 767 PLVVFAGVEYGNGSSRDWAAKGTNLLGVKAVIAQSFERIHRSNLVGMGIVPFVFEEGTSWQTLGLkGDEM 836
Cdd:cd00404   16 PGVVIGDENYGTGSSREHAALELRLLGGRAVIAKSFARIFFRNLVDQGLLPLEFADPEDYLKLHT-GDEL 84
PRK14023 PRK14023
homoaconitate hydratase small subunit; Provisional
769-822 6.82e-10

homoaconitate hydratase small subunit; Provisional


Pssm-ID: 184460 [Multi-domain]  Cd Length: 166  Bit Score: 58.66  E-value: 6.82e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 500733028 769 VVFAGVEYGNGSSRDWAAKGTNLLGVKAVIAQSFERIHRSNLVGMGIVPFVFEE 822
Cdd:PRK14023  52 ILVAGRNFGLGSSREYAPEALKMLGIGAIIAKSYARIFYRNLVNLGIPPFESEE 105
IPMI_Swivel cd01577
Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized ...
769-839 1.44e-08

Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate 3-isopropylmalate. IPMI is involved in fungal and bacterial leucine biosynthesis and is also found in eukaryotes. This is the aconitase-like swivel domain, which is believed to undergo swivelling conformational change in the enzyme mechanism.


Pssm-ID: 238809 [Multi-domain]  Cd Length: 91  Bit Score: 52.98  E-value: 1.44e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 500733028 769 VVFAGVEYGNGSSR---DWAAKGtnlLGVKAVIAQSFERIHRSNLVGMGIVPFVFEEGTSWQTLGLKGDEmVTI 839
Cdd:cd01577   20 IIVAGKNFGCGSSRehaPWALKD---AGIRAVIAESFARIFFRNAINNGLLPVTLADEDVEEVEAKPGDE-VEV 89
AcnB cd01581
Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA ...
207-563 6.75e-08

Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Aconitase B catalytic domain. Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle. Aconitase has an active (4FE-4S) and an inactive (3FE-4S) form. The active cluster is part of the catalytic site that interconverts citrate, cis-aconitase and isocitrate. The domain architecture of aconitase B is different from other aconitases in that the catalytic domain is normally found at C-terminus for other aconitases, but it is at N-terminus for B family. It also has a HEAT domain before domain 4 which plays a role in protein-protein interaction. This alignment is the core domain including domains 1,2 and 3.


Pssm-ID: 153131  Cd Length: 436  Bit Score: 55.97  E-value: 6.75e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 207 PDTC-VGTDSHTTMvnGLGVLGWGVGGIEAEAAMLGQ-PVSMllPEVVGFRLTGKIKEGVTATDLV------------LT 272
Cdd:cd01581  106 PDTVgTGGDSHTRF--PIGISFPAGSGLVAFAAATGVmPLDM--PESVLVRFKGKMQPGITLRDLVnaipyyaiqqglLT 181
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 273 VTQMLRKKGVVGKFVEFfgEGLENMTLADRATIANMGPEYGATCGFFPVDRETL-NYMNTT----------GRD-----E 336
Cdd:cd01581  182 VEKKGKKNVFNGRILEI--EGLPDLKVEQAFELTDASAERSAAACTVRLDKEPViEYLESNvvlmkimianGYDdartlL 259
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 337 HRIELVEAycraqgmWRD-----KGAADPVFTDILELDMSDVV-PSMAGPKRPegrialENIASgfatsleneykkttgq 410
Cdd:cd01581  260 RRIIAMEE-------WLAnppllEPDADAEYAAVIEIDLDDIKePILACPNDP------DDVKL---------------- 310
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 411 taRYAVEGEDYDLGHgdvaiaaITSCtnTSNPSVLIAAGLLARNavAKGLKTKPWVktslAPGSQVVAAYLESAGLQKDL 490
Cdd:cd01581  311 --LSEVAGKKIDEVF-------IGSC--MTNIGHFRAAAKILRG--KEFKPTRLWV----APPTRMDWAILQEEGYYSIF 373
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 500733028 491 DALGFNLVGFGCTTCIGNSGPLPapisktineKGliaAAVLS-GNRNFEGRVSPDVQAnYLASPPLVVAHALAG 563
Cdd:cd01581  374 GDAGARTEMPGCSLCMGNQARVA---------DG---ATVFStSTRNFDNRVGKGAEV-YLGSAELAAVCALLG 434
PRK11413 PRK11413
putative hydratase; Provisional
175-383 8.04e-07

putative hydratase; Provisional


Pssm-ID: 183125 [Multi-domain]  Cd Length: 751  Bit Score: 53.09  E-value: 8.04e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 175 VPPGTGICHQVNLEYLAQAvwtkeedGETVaypdtcVGTDSHT------TMvnglgvlgwgvgGI-----EAEAAMLGQP 243
Cdd:PRK11413 123 VPPHIAVIHQYMREMMAGG-------GKMI------LGSDSHTrygalgTM------------AVgegggELVKQLLNDT 177
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 244 VSMLLPEVVGFRLTGKIKEGVTATDLVLTVTQMLRKKGVV-GKFVEFFGEGLENMTLADRATIANMGPEygATC--GFFP 320
Cdd:PRK11413 178 YDIDYPGVVAVYLTGKPAPGVGPQDVALAIIGAVFKNGYVkNKVMEFVGPGVSALSTDFRNGVDVMTTE--TTClsSIWQ 255
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 500733028 321 VDRETLNYMNTTGRdehrielVEAYCRAQgmwrdkgAADPVFTD-ILELDMSDVVPSMAGPKRP 383
Cdd:PRK11413 256 TDEEVHNWLALHGR-------GQDYCELN-------PQPMAYYDgCISVDLSAIKPMIALPFHP 305
leuD PRK00439
3-isopropylmalate dehydratase small subunit; Reviewed
769-815 4.85e-05

3-isopropylmalate dehydratase small subunit; Reviewed


Pssm-ID: 234762 [Multi-domain]  Cd Length: 163  Bit Score: 44.43  E-value: 4.85e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 500733028 769 VVFAGVEYGNGSSRDWAAKGTNLLGVKAVIAQSFERIHRSNLVGMGI 815
Cdd:PRK00439  51 IIVAGKNFGCGSSREHAPIALKAAGVSAVIAKSFARIFYRNAINIGL 97
PLN00094 PLN00094
aconitate hydratase 2; Provisional
207-563 3.81e-04

aconitate hydratase 2; Provisional


Pssm-ID: 215053 [Multi-domain]  Cd Length: 938  Bit Score: 44.14  E-value: 3.81e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 207 PDTcVGT--DSHTTMvnGLGVLGWGVGGIEAEAAMLG-QPVSMllPEVVGFRLTGKIKEGVTATDLV------------L 271
Cdd:PLN00094 552 PDT-VGTggDSHTRF--PIGISFPAGSGLVAFGAATGvIPLDM--PESVLVRFTGTMQPGITLRDLVhaipytaiqdglL 626
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 272 TVTQMLRKKGVVGKFVEFfgEGLENMTLADRATIANMGPEYGATCGFFPVDRET-----------LNYMNTTGRD----- 335
Cdd:PLN00094 627 TVEKKGKKNVFSGRILEI--EGLPHLKCEQAFELSDASAERSAAGCTIKLDKEPiieylnsnvvmLKWMIAEGYGdrrtl 704
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 336 EHRIELVEAYCRAQGMWRdkgaADP--VFTDILELDMSDVV-PSMAGPKRPEgrialeniasgfATSLENEykkttgqta 412
Cdd:PLN00094 705 ERRIARMQQWLADPELLE----ADPdaEYAAVIEIDMDEIKePILCAPNDPD------------DARLLSE--------- 759
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500733028 413 ryaVEGEDYDlghgDVAIAaitSCtnTSNPSVLIAAGLLArNAVAKGLKTKPWVktslAPGSQVVAAYLESAGLQKDLDA 492
Cdd:PLN00094 760 ---VTGDKID----EVFIG---SC--MTNIGHFRAAGKLL-NDNLSQLPTRLWV----APPTKMDEAQLKAEGYYSTFGT 822
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 500733028 493 LGFNLVGFGCTTCIGNSGplpapiskTINEKgliAAAVLSGNRNFEGRVSPDvqAN-YLASPPLVVAHALAG 563
Cdd:PLN00094 823 VGARTEMPGCSLCMGNQA--------RVAEK---STVVSTSTRNFPNRLGKG--ANvYLASAELAAVAAILG 881
PRK14812 PRK14812
hypothetical protein; Provisional
779-840 3.21e-03

hypothetical protein; Provisional


Pssm-ID: 173273 [Multi-domain]  Cd Length: 119  Bit Score: 38.55  E-value: 3.21e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 500733028 779 GSSRDWAAKGTNLLGVKAVIAQSFERIHRSNLVGMGIVPFVFEEGTSWQTLGLKGDEMVTIE 840
Cdd:PRK14812   3 GSSREHAAWALADYGFKVVIAGSFGDIHYNNELNNGMLPIVQPREVREKLAQLKPTDQVTVD 64
PLN00072 PLN00072
3-isopropylmalate isomerase/dehydratase small subunit; Provisional
769-840 4.14e-03

3-isopropylmalate isomerase/dehydratase small subunit; Provisional


Pssm-ID: 177701 [Multi-domain]  Cd Length: 246  Bit Score: 39.84  E-value: 4.14e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 500733028 769 VVFAGVEYGNGSSRDWAAKGTNLLGVKAVIAQSFERIHRSNLVGMGIVPFVFEEGTSWQTlgLKGDEMVTIE 840
Cdd:PLN00072 132 IIIGGENFGCGSSREHAPVALGAAGAKAVVAESYARIFFRNSVATGEVYPLESEVRICEE--CKTGDVVTVE 201
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH