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Conserved domains on  [gi|500742475|ref|WP_011984163|]
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MULTISPECIES: Lrp/AsnC family transcriptional regulator [Bacillus cereus group]

Protein Classification

Lrp/AsnC family transcriptional regulator( domain architecture ID 11445815)

Lrp/AsnC (leucine-responsive regulatory protein/asparagine synthase C) family transcriptional regulator regulates many cellular processes such as amino acid metabolism, pili synthesis, and DNA repair and recombination

CATH:  3.30.70.920|1.10.10.10
Gene Ontology:  GO:0043565
PubMed:  16438681|21608015|27206730

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
1-134 5.38e-41

DNA-binding transcriptional regulator, Lrp family [Transcription];


:

Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 133.75  E-value: 5.38e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500742475   1 MQLDRVDRKILNELYNDSRLSMRELSKRVNLSAPSTTERVRKLESEGVIRKYTIDIDYKKAGLVLDCILEITLKNGDTTR 80
Cdd:COG1522    1 MELDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVPPHRLDE 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 500742475  81 MQQFIQSYPSASFCYRVTGSLCYIVKISVPSLVELEEFIND----VSSYATTVSHIVL 134
Cdd:COG1522   81 FAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLLErlaaLPGVRRTETSFVL 138
 
Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
1-134 5.38e-41

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 133.75  E-value: 5.38e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500742475   1 MQLDRVDRKILNELYNDSRLSMRELSKRVNLSAPSTTERVRKLESEGVIRKYTIDIDYKKAGLVLDCILEITLKNGDTTR 80
Cdd:COG1522    1 MELDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVPPHRLDE 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 500742475  81 MQQFIQSYPSASFCYRVTGSLCYIVKISVPSLVELEEFIND----VSSYATTVSHIVL 134
Cdd:COG1522   81 FAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLLErlaaLPGVRRTETSFVL 138
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 3-107 1.22e-34

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 116.46  E-value: 1.22e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500742475     3 LDRVDRKILNELYNDSRLSMRELSKRVNLSAPSTTERVRKLESEGVIRKYTIDIDYKKAGLVLDCILEITLKNGDT-TRM 81
Cdd:smart00344   1 LDEIDRKILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVIKGYTAVLNPKKLGLSVTAFVGVTLENPDKlEEF 80

                           90       100
                   ....*....|....*....|....*.
gi 500742475    82 QQFIQSYPSASFCYRVTGSLCYIVKI 107
Cdd:smart00344  81 LEKLEKLPEVEEVYLVTGDYDYLLKV 106
PRK11169 PRK11169
leucine-responsive transcriptional regulator Lrp;
3-140 1.05e-19

leucine-responsive transcriptional regulator Lrp;


Pssm-ID: 183009 [Multi-domain]  Cd Length: 164  Bit Score: 80.19  E-value: 1.05e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500742475   3 LDRVDRKILNELYNDSRLSMRELSKRVNLSAPSTTERVRKLESEGVIRKYTIDIDYKKAGLVLDCILEITLKNGDTTRMQ 82
Cdd:PRK11169  12 LDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIQGYTALLNPHYLDASLLVFVEITLNRGAPDVFE 91

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 500742475  83 QF---IQSYPSASFCYRVTGSLCYIVKISVPSLVELEEFIND----VSSYATTVSHIVLSEVALT 140
Cdd:PRK11169  92 QFnaaVQKLEEIQECHLVSGDFDYLLKTRVPDMSAYRKLLGEtllrLPGVNDTRTYVVMEEVKQT 156
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
5-49 7.29e-14

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 61.68  E-value: 7.29e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 500742475    5 RVDRKILNELYNDSRLSMRELSKRVNLSAPSTTERVRKLESEGVI 49
Cdd:pfam13412   1 ETDRKILNLLQENPRISQRELAERLGLSPSTVNRRLKRLEEEGVI 45
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 4-52 3.61e-06

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 42.67  E-value: 3.61e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 500742475   4 DRVDRKILNELYnDSRLSMRELSKRVNLSAPSTTERVRKLESEGVIRKY 52
Cdd:cd00090    6 DPTRLRILRLLL-EGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESR 53
cas_HTH TIGR01884
CRISPR locus-related DNA-binding protein; Most but not all examples of this family are ...
 3-51 6.55e-03

CRISPR locus-related DNA-binding protein; Most but not all examples of this family are associated with CRISPR loci, a combination of DNA repeats and characteristic proteins encoded near the repeat cluster. The C-terminal region of this protein is homologous to DNA-binding helix-turn-helix domains with predicted transcriptional regulatory activity. [Regulatory functions, DNA interactions, , ]


Pssm-ID: 273852 [Multi-domain]  Cd Length: 203  Bit Score: 35.41  E-value: 6.55e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 500742475    3 LDRVDRKILNELYNDSRLSMRELSKRVNLSAPSTTERVRKLESEGVIRK 51
Cdd:TIGR01884 141 LSREELKILEVLKATGEKSVKNIAKKLGKSLSTISRHLAELEKKGLVEQ 189
 
Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
1-134 5.38e-41

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 133.75  E-value: 5.38e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500742475   1 MQLDRVDRKILNELYNDSRLSMRELSKRVNLSAPSTTERVRKLESEGVIRKYTIDIDYKKAGLVLDCILEITLKNGDTTR 80
Cdd:COG1522    1 MELDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVPPHRLDE 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 500742475  81 MQQFIQSYPSASFCYRVTGSLCYIVKISVPSLVELEEFIND----VSSYATTVSHIVL 134
Cdd:COG1522   81 FAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLLErlaaLPGVRRTETSFVL 138
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 3-107 1.22e-34

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 116.46  E-value: 1.22e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500742475     3 LDRVDRKILNELYNDSRLSMRELSKRVNLSAPSTTERVRKLESEGVIRKYTIDIDYKKAGLVLDCILEITLKNGDT-TRM 81
Cdd:smart00344   1 LDEIDRKILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVIKGYTAVLNPKKLGLSVTAFVGVTLENPDKlEEF 80

                           90       100
                   ....*....|....*....|....*.
gi 500742475    82 QQFIQSYPSASFCYRVTGSLCYIVKI 107
Cdd:smart00344  81 LEKLEKLPEVEEVYLVTGDYDYLLKV 106
PRK11169 PRK11169
leucine-responsive transcriptional regulator Lrp;
3-140 1.05e-19

leucine-responsive transcriptional regulator Lrp;


Pssm-ID: 183009 [Multi-domain]  Cd Length: 164  Bit Score: 80.19  E-value: 1.05e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500742475   3 LDRVDRKILNELYNDSRLSMRELSKRVNLSAPSTTERVRKLESEGVIRKYTIDIDYKKAGLVLDCILEITLKNGDTTRMQ 82
Cdd:PRK11169  12 LDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIQGYTALLNPHYLDASLLVFVEITLNRGAPDVFE 91

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 500742475  83 QF---IQSYPSASFCYRVTGSLCYIVKISVPSLVELEEFIND----VSSYATTVSHIVLSEVALT 140
Cdd:PRK11169  92 QFnaaVQKLEEIQECHLVSGDFDYLLKTRVPDMSAYRKLLGEtllrLPGVNDTRTYVVMEEVKQT 156
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
5-49 7.29e-14

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 61.68  E-value: 7.29e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 500742475    5 RVDRKILNELYNDSRLSMRELSKRVNLSAPSTTERVRKLESEGVI 49
Cdd:pfam13412   1 ETDRKILNLLQENPRISQRELAERLGLSPSTVNRRLKRLEEEGVI 45
HTH_AsnC-type pfam13404
AsnC-type helix-turn-helix domain;
4-44 3.35e-13

AsnC-type helix-turn-helix domain;


Pssm-ID: 433180 [Multi-domain]  Cd Length: 41  Bit Score: 59.69  E-value: 3.35e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 500742475    4 DRVDRKILNELYNDSRLSMRELSKRVNLSAPSTTERVRKLE 44
Cdd:pfam13404   1 DEIDRKILRLLQEDARISFAELAERVGLSESTVLRRIRRLE 41
PRK11179 PRK11179
DNA-binding transcriptional regulator AsnC; Provisional
 1-130 1.22e-11

DNA-binding transcriptional regulator AsnC; Provisional


Pssm-ID: 183019 [Multi-domain]  Cd Length: 153  Bit Score: 58.57  E-value: 1.22e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500742475   1 MQLDRVDRKILNELYNDSRLSMRELSKRVNLSAPSTTERVRKLESEGVIRKYTIDIDYKKAGLVLDCILEITLKN-GDTT 79
Cdd:PRK11179   5 YQIDNLDRGILEALMENARTPYAELAKQFGVSPGTIHVRVEKMKQAGIITGTRVDVNPKQLGYDVCCFIGIILKSaKDYP 84

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 500742475  80 RMQQFIQSYPSASFCYRVTGSLCYIVKISVPSLVELE-------EFINDVSSYATTVS 130
Cdd:PRK11179  85 SALAKLESLDEVVEAYYTTGHYSIFIKVMCRSIDALQhvlinkiQTIDEIQSTETLIS 142
AsnC_trans_reg pfam01037
Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family ...
 69-136 1.05e-09

Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family is a family of similar bacterial transcription regulatory proteins. The family is named after two E. coli proteins involved in regulating amino acid metabolism. This entry corresponds to the usually C-terminal regulatory ligand binding domain. Structurally this domain has a dimeric alpha/beta barrel fold. This domain binds almost exclusively amino acids but also 4-hydroxyphenylpyruvate and kynurenine (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426007  Cd Length: 73  Bit Score: 51.76  E-value: 1.05e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 500742475   69 LEITLKNG-DTTRMQQFIQSYPSASFCYRVTGSLCYIVKISVPSLVELEEFIND----VSSYATTVSHIVLSE 136
Cdd:pfam01037   1 VEVKLEPGhALEEFAEALAAIPEVVECYRVTGDYDYLLKVVARDLEALERFLREklrsLPGVARTETSIVLST 73
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 4-52 3.61e-06

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 42.67  E-value: 3.61e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 500742475   4 DRVDRKILNELYnDSRLSMRELSKRVNLSAPSTTERVRKLESEGVIRKY 52
Cdd:cd00090    6 DPTRLRILRLLL-EGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESR 53
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 2-51 9.89e-05

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 38.34  E-value: 9.89e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 500742475    2 QLDRVDRKILNELYNDSRLSMRELSKRVNLSAPSTTERVRKLESEGVIRK 51
Cdd:pfam12802   2 GLTPAQFRVLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVER 51
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
9-57 4.70e-04

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 37.19  E-value: 4.70e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 500742475     9 KILNELYNDSRLSMRELSKRVNLSAPSTTERVRKLESEGVIRKYTIDID 57
Cdd:smart00347  14 LVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPED 62
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 9-52 7.20e-04

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 35.99  E-value: 7.20e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 500742475    9 KILNELYNDSRLSMRELSKRVNLSAPSTTERVRKLESEGVIRKY 52
Cdd:pfam01047   7 HILRILYEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIERS 50
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
3-51 1.12e-03

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 36.87  E-value: 1.12e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 500742475   3 LDRVDRKILNELYNDSRLSMRELSKRVNLSAPSTTERVRKLESEGVIRK 51
Cdd:COG1846   36 LTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVER 84
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
9-52 3.51e-03

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 34.11  E-value: 3.51e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 500742475     9 KILNELYNDSrLSMRELSKRVNLSAPSTTERVRKLESEGVIRKY 52
Cdd:smart00418   1 KILKLLAEGE-LCVCELAEILGLSQSTVSHHLKKLREAGLVESR 43
cas_HTH TIGR01884
CRISPR locus-related DNA-binding protein; Most but not all examples of this family are ...
 3-51 6.55e-03

CRISPR locus-related DNA-binding protein; Most but not all examples of this family are associated with CRISPR loci, a combination of DNA repeats and characteristic proteins encoded near the repeat cluster. The C-terminal region of this protein is homologous to DNA-binding helix-turn-helix domains with predicted transcriptional regulatory activity. [Regulatory functions, DNA interactions, , ]


Pssm-ID: 273852 [Multi-domain]  Cd Length: 203  Bit Score: 35.41  E-value: 6.55e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 500742475    3 LDRVDRKILNELYNDSRLSMRELSKRVNLSAPSTTERVRKLESEGVIRK 51
Cdd:TIGR01884 141 LSREELKILEVLKATGEKSVKNIAKKLGKSLSTISRHLAELEKKGLVEQ 189
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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