NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|500899009|ref|WP_012013654|]
View 

ATP-grasp peptide maturase system methyltransferase [Salinispora tropica]

Protein Classification

methyltr_grsp family protein( domain architecture ID 11499493)

methyltr_grsp family protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
methyltr_grsp TIGR04188
methyltransferase, ATP-grasp peptide maturase system; Members of this protein family are ...
 12-371 5.12e-162

methyltransferase, ATP-grasp peptide maturase system; Members of this protein family are predicted SAM-dependent methyltransferases that regularly occur in the context of a putative peptide modification ATP-grasp enzyme (TIGR04187, related to enzymes of microviridin maturation) and a putative ribosomal peptide modification target (TIGR04186).


:

Pssm-ID: 275041  Cd Length: 363  Bit Score: 458.36  E-value: 5.12e-162
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500899009   12 LVHELTGHGWLTE-AWRTAFAAVPRHLFLTRFFRQTPDRSRYEAVDVNDLGA---LELIYSDRVLPTQLDGDDARwDESR 87
Cdd:TIGR04188   1 LAARLAAAGVLTDpAWREAVEAVPRHLFLPGFFTQLPDGRGWRPVTADRPDPdewLALVYSDETLVTQLDGDLAA-DAAG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500899009   88 hhGPLAGVPTCSSTQPALMAVMLDALDVADGHRVLEVGTGTGYNAALLAHRLGSPLVTTVDIDAGLVRRARQSLTSVGYA 167
Cdd:TIGR04188  80 --GPVTGRPTSSSTQPSLVARMLEALDVEDGHRVLEIGTGTGYSAALLCHRLGDDNVTSVEVDPGLAARAASALAAAGYA 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500899009  168 PTVAATDGEAGYPGNAPYDRIIAACSVPQVPTGWLAQSRPGGVILTSLHREIGGGLLLRLTVDETGTASGHLLDDYGSFM 247
Cdd:TIGR04188 158 PTVVTGDGLLGHPPRAPYDRIIATCAVRRVPPAWLRQTRPGGVILTTLSGWLYGGGLVRLTVDDDGTAEGRFLPGYASFM 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500899009  248 PLRSCPTVRTSALVRAASQATGDRHKTHLPGPLADDGEAwTALVALLLPDVARLDLGRPEGPVQ-WLVHPDGSWAYHDI- 325
Cdd:TIGR04188 238 PARPQAPPPAAGDLSAAAADAGDRRTTRLPPALLEDWTG-AFLAQLAAPDAQLLTLTPDTGSPQvLLDVADGSWAELTPd 316

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 500899009  326 -STQTVEQGGPRRLWTEVEDLYSRWTAHGKPSRSHIGVTITPAGQQV 371
Cdd:TIGR04188 317 gGGWTVRQGGPRRLWDAVEEALDAWQAAGRPDRDAFGLTVTPNGHHV 363
 
Name Accession Description Interval E-value
methyltr_grsp TIGR04188
methyltransferase, ATP-grasp peptide maturase system; Members of this protein family are ...
 12-371 5.12e-162

methyltransferase, ATP-grasp peptide maturase system; Members of this protein family are predicted SAM-dependent methyltransferases that regularly occur in the context of a putative peptide modification ATP-grasp enzyme (TIGR04187, related to enzymes of microviridin maturation) and a putative ribosomal peptide modification target (TIGR04186).


Pssm-ID: 275041  Cd Length: 363  Bit Score: 458.36  E-value: 5.12e-162
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500899009   12 LVHELTGHGWLTE-AWRTAFAAVPRHLFLTRFFRQTPDRSRYEAVDVNDLGA---LELIYSDRVLPTQLDGDDARwDESR 87
Cdd:TIGR04188   1 LAARLAAAGVLTDpAWREAVEAVPRHLFLPGFFTQLPDGRGWRPVTADRPDPdewLALVYSDETLVTQLDGDLAA-DAAG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500899009   88 hhGPLAGVPTCSSTQPALMAVMLDALDVADGHRVLEVGTGTGYNAALLAHRLGSPLVTTVDIDAGLVRRARQSLTSVGYA 167
Cdd:TIGR04188  80 --GPVTGRPTSSSTQPSLVARMLEALDVEDGHRVLEIGTGTGYSAALLCHRLGDDNVTSVEVDPGLAARAASALAAAGYA 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500899009  168 PTVAATDGEAGYPGNAPYDRIIAACSVPQVPTGWLAQSRPGGVILTSLHREIGGGLLLRLTVDETGTASGHLLDDYGSFM 247
Cdd:TIGR04188 158 PTVVTGDGLLGHPPRAPYDRIIATCAVRRVPPAWLRQTRPGGVILTTLSGWLYGGGLVRLTVDDDGTAEGRFLPGYASFM 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500899009  248 PLRSCPTVRTSALVRAASQATGDRHKTHLPGPLADDGEAwTALVALLLPDVARLDLGRPEGPVQ-WLVHPDGSWAYHDI- 325
Cdd:TIGR04188 238 PARPQAPPPAAGDLSAAAADAGDRRTTRLPPALLEDWTG-AFLAQLAAPDAQLLTLTPDTGSPQvLLDVADGSWAELTPd 316

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 500899009  326 -STQTVEQGGPRRLWTEVEDLYSRWTAHGKPSRSHIGVTITPAGQQV 371
Cdd:TIGR04188 317 gGGWTVRQGGPRRLWDAVEEALDAWQAAGRPDRDAFGLTVTPNGHHV 363
Pcm COG2518
Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, ...
 13-250 3.20e-53

Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442008 [Multi-domain]  Cd Length: 197  Bit Score: 174.89  E-value: 3.20e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500899009  13 VHELTGHGWLTEAWRTAFAAVPRHLFLTRFFRqtpdrsryeavdvndlgalELIYSDRVLPtqLDgddarwdesrhHGpl 92
Cdd:COG2518    1 VQQLRPRGVTDPRVLDAMRAVPRELFVPEALR-------------------ELAYADRALP--IG-----------HG-- 46

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500899009  93 agvptCSSTQPALMAVMLDALDVADGHRVLEVGTGTGYNAALLAHRLGSplVTTVDIDAGLVRRARQSLTSVGYA-PTVA 171
Cdd:COG2518   47 -----QTISQPYIVARMLEALDLKPGDRVLEIGTGSGYQAAVLARLAGR--VYSVERDPELAERARERLAALGYDnVTVR 119

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 500899009 172 ATDGEAGYPGNAPYDRIIAACSVPQVPTGWLAQSRPGGVILTSLHREiGGGLLLRLTVDETGtASGHLLDDYgSFMPLR 250
Cdd:COG2518  120 VGDGALGWPEHAPFDRIIVTAAAPEVPEALLEQLAPGGRLVAPVGEG-GVQRLVLITRTGDG-FERESLFEV-RFVPLR 195
pcm PRK00312
protein-L-isoaspartate(D-aspartate) O-methyltransferase;
1-212 5.35e-31

protein-L-isoaspartate(D-aspartate) O-methyltransferase;


Pssm-ID: 178974 [Multi-domain]  Cd Length: 212  Bit Score: 117.23  E-value: 5.35e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500899009   1 MTATAERARNRLVHELTGHGWLTEAWRTAFAAVPRHLFLtrffrqtPDRSRYEAvdvndlgaleliYSDRVLPTQldgdd 80
Cdd:PRK00312   1 ARLMESERFARLVLRLRAEGILDERVLEAIEATPRELFV-------PEAFKHKA------------YENRALPIG----- 56

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500899009  81 arwdesrhhgplagvptCSST--QPALMAVMLDALDVADGHRVLEVGTGTGYNAALLAHRLGspLVTTVDIDAGLVRRAR 158
Cdd:PRK00312  57 -----------------CGQTisQPYMVARMTELLELKPGDRVLEIGTGSGYQAAVLAHLVR--RVFSVERIKTLQWEAK 117

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 500899009 159 QSLTSVGYAP-TVAATDGEAGYPGNAPYDRIIAACSVPQVPTGWLAQSRPGGVIL 212
Cdd:PRK00312 118 RRLKQLGLHNvSVRHGDGWKGWPAYAPFDRILVTAAAPEIPRALLEQLKEGGILV 172
PCMT pfam01135
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);
10-212 4.32e-27

Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);


Pssm-ID: 395902 [Multi-domain]  Cd Length: 205  Bit Score: 106.68  E-value: 4.32e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500899009   10 NRLVHELTGHGW-LTEAWRTAFAAVPRHLFLTRFFRQTPdrsryeavdvndlgaleliYSDRVLPTQLDGddarwdesrh 88
Cdd:pfam01135   4 EALIENLKNYGViKSDKVAEAMLAVDREEFVPESFKSYA-------------------YEDIPLSIGYGQ---------- 54

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500899009   89 hgplagvptcSSTQPALMAVMLDALDVADGHRVLEVGTGTGYNAALLAHRLG-SPLVTTVDIDAGLVRRARQSLTSVGYA 167
Cdd:pfam01135  55 ----------TISAPHMHAMMLELLELKPGMRVLEIGSGSGYLTACFARMVGeVGRVVSIEHIPELVEIARRNLEKLGLE 124

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 500899009  168 P-TVAATDGEAGYPGNAPYDRIIAACSVPQVPTGWLAQSRPGGVIL 212
Cdd:pfam01135 125 NvIVVVGDGRQGWPEFAPYDAIHVGAAAPEIPEALIDQLKEGGRLV 170
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 120-215 1.30e-06

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 46.65  E-value: 1.30e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500899009 120 RVLEVGTGTGYNAALLAHRLGsPLVTTVDIDAGLVRRARQSLTSVGYAP-TVAATDGEAG-YPGNAPYDRII---AACSV 194
Cdd:cd02440    1 RVLDLGCGTGALALALASGPG-ARVTGVDISPVALELARKAAAALLADNvEVLKGDAEELpPEADESFDVIIsdpPLHHL 79

                         90       100
                 ....*....|....*....|....*
gi 500899009 195 PQVPTGWLAQ----SRPGGVILTSL 215
Cdd:cd02440   80 VEDLARFLEEarrlLKPGGVLVLTL 104
 
Name Accession Description Interval E-value
methyltr_grsp TIGR04188
methyltransferase, ATP-grasp peptide maturase system; Members of this protein family are ...
 12-371 5.12e-162

methyltransferase, ATP-grasp peptide maturase system; Members of this protein family are predicted SAM-dependent methyltransferases that regularly occur in the context of a putative peptide modification ATP-grasp enzyme (TIGR04187, related to enzymes of microviridin maturation) and a putative ribosomal peptide modification target (TIGR04186).


Pssm-ID: 275041  Cd Length: 363  Bit Score: 458.36  E-value: 5.12e-162
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500899009   12 LVHELTGHGWLTE-AWRTAFAAVPRHLFLTRFFRQTPDRSRYEAVDVNDLGA---LELIYSDRVLPTQLDGDDARwDESR 87
Cdd:TIGR04188   1 LAARLAAAGVLTDpAWREAVEAVPRHLFLPGFFTQLPDGRGWRPVTADRPDPdewLALVYSDETLVTQLDGDLAA-DAAG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500899009   88 hhGPLAGVPTCSSTQPALMAVMLDALDVADGHRVLEVGTGTGYNAALLAHRLGSPLVTTVDIDAGLVRRARQSLTSVGYA 167
Cdd:TIGR04188  80 --GPVTGRPTSSSTQPSLVARMLEALDVEDGHRVLEIGTGTGYSAALLCHRLGDDNVTSVEVDPGLAARAASALAAAGYA 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500899009  168 PTVAATDGEAGYPGNAPYDRIIAACSVPQVPTGWLAQSRPGGVILTSLHREIGGGLLLRLTVDETGTASGHLLDDYGSFM 247
Cdd:TIGR04188 158 PTVVTGDGLLGHPPRAPYDRIIATCAVRRVPPAWLRQTRPGGVILTTLSGWLYGGGLVRLTVDDDGTAEGRFLPGYASFM 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500899009  248 PLRSCPTVRTSALVRAASQATGDRHKTHLPGPLADDGEAwTALVALLLPDVARLDLGRPEGPVQ-WLVHPDGSWAYHDI- 325
Cdd:TIGR04188 238 PARPQAPPPAAGDLSAAAADAGDRRTTRLPPALLEDWTG-AFLAQLAAPDAQLLTLTPDTGSPQvLLDVADGSWAELTPd 316

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 500899009  326 -STQTVEQGGPRRLWTEVEDLYSRWTAHGKPSRSHIGVTITPAGQQV 371
Cdd:TIGR04188 317 gGGWTVRQGGPRRLWDAVEEALDAWQAAGRPDRDAFGLTVTPNGHHV 363
Pcm COG2518
Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, ...
 13-250 3.20e-53

Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442008 [Multi-domain]  Cd Length: 197  Bit Score: 174.89  E-value: 3.20e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500899009  13 VHELTGHGWLTEAWRTAFAAVPRHLFLTRFFRqtpdrsryeavdvndlgalELIYSDRVLPtqLDgddarwdesrhHGpl 92
Cdd:COG2518    1 VQQLRPRGVTDPRVLDAMRAVPRELFVPEALR-------------------ELAYADRALP--IG-----------HG-- 46

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500899009  93 agvptCSSTQPALMAVMLDALDVADGHRVLEVGTGTGYNAALLAHRLGSplVTTVDIDAGLVRRARQSLTSVGYA-PTVA 171
Cdd:COG2518   47 -----QTISQPYIVARMLEALDLKPGDRVLEIGTGSGYQAAVLARLAGR--VYSVERDPELAERARERLAALGYDnVTVR 119

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 500899009 172 ATDGEAGYPGNAPYDRIIAACSVPQVPTGWLAQSRPGGVILTSLHREiGGGLLLRLTVDETGtASGHLLDDYgSFMPLR 250
Cdd:COG2518  120 VGDGALGWPEHAPFDRIIVTAAAPEVPEALLEQLAPGGRLVAPVGEG-GVQRLVLITRTGDG-FERESLFEV-RFVPLR 195
methyltran_FxLD TIGR04364
methyltransferase, FxLD system; Members of this family resemble occur regularly in the ...
 5-215 3.68e-31

methyltransferase, FxLD system; Members of this family resemble occur regularly in the vicinity of lantibiotic biosynthesis enzymes and their probable target, the FxLD family of putative ribosomal natural product precursor (TIGR04363). Members resemble protein-L-isoaspartate O-methyltransferase (TIGR00080) and a predicted methyltranserase, TIGR04188, of another putative peptide modification system.


Pssm-ID: 275158  Cd Length: 394  Bit Score: 122.09  E-value: 3.68e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500899009    5 AERARNRLVHELTGHGWL-TEAWRTAFAAVPRHLFLtrffrqtPDRSryeavdvndlgaLELIYS-DRVLPTQLDGDdar 82
Cdd:TIGR04364   1 AARLRAALVDELREDGVIrSPRVEAAFRTVPRHLFA-------PGAP------------LEKAYAaNRAVVTKRDED--- 58

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500899009   83 wdesrhhgplaGVPTCSSTQPALMAVMLDALDVADGHRVLEVGTGtGYNAALLAHRLG-SPLVTTVDIDAGLVRRARQSL 161
Cdd:TIGR04364  59 -----------GRALSSVSAPHIQAMMLEQAGVEPGMRVLEIGSG-GYNAALLAELVGpSGEVTTVDIDEDVTDRARACL 126

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 500899009  162 TSVGYAP-TVAATDGEAGYPGNAPYDRIIAACSVPQVPTGWLAQSRPGGVILTSL 215
Cdd:TIGR04364 127 AAAGYPQvTVVLADAEAGVPELAPYDRIIVTVGAWDIPPAWLDQLAPGGRLVVPL 181
pcm PRK00312
protein-L-isoaspartate(D-aspartate) O-methyltransferase;
1-212 5.35e-31

protein-L-isoaspartate(D-aspartate) O-methyltransferase;


Pssm-ID: 178974 [Multi-domain]  Cd Length: 212  Bit Score: 117.23  E-value: 5.35e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500899009   1 MTATAERARNRLVHELTGHGWLTEAWRTAFAAVPRHLFLtrffrqtPDRSRYEAvdvndlgaleliYSDRVLPTQldgdd 80
Cdd:PRK00312   1 ARLMESERFARLVLRLRAEGILDERVLEAIEATPRELFV-------PEAFKHKA------------YENRALPIG----- 56

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500899009  81 arwdesrhhgplagvptCSST--QPALMAVMLDALDVADGHRVLEVGTGTGYNAALLAHRLGspLVTTVDIDAGLVRRAR 158
Cdd:PRK00312  57 -----------------CGQTisQPYMVARMTELLELKPGDRVLEIGTGSGYQAAVLAHLVR--RVFSVERIKTLQWEAK 117

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 500899009 159 QSLTSVGYAP-TVAATDGEAGYPGNAPYDRIIAACSVPQVPTGWLAQSRPGGVIL 212
Cdd:PRK00312 118 RRLKQLGLHNvSVRHGDGWKGWPAYAPFDRILVTAAAPEIPRALLEQLKEGGILV 172
PCMT pfam01135
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);
10-212 4.32e-27

Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);


Pssm-ID: 395902 [Multi-domain]  Cd Length: 205  Bit Score: 106.68  E-value: 4.32e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500899009   10 NRLVHELTGHGW-LTEAWRTAFAAVPRHLFLTRFFRQTPdrsryeavdvndlgaleliYSDRVLPTQLDGddarwdesrh 88
Cdd:pfam01135   4 EALIENLKNYGViKSDKVAEAMLAVDREEFVPESFKSYA-------------------YEDIPLSIGYGQ---------- 54

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500899009   89 hgplagvptcSSTQPALMAVMLDALDVADGHRVLEVGTGTGYNAALLAHRLG-SPLVTTVDIDAGLVRRARQSLTSVGYA 167
Cdd:pfam01135  55 ----------TISAPHMHAMMLELLELKPGMRVLEIGSGSGYLTACFARMVGeVGRVVSIEHIPELVEIARRNLEKLGLE 124

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 500899009  168 P-TVAATDGEAGYPGNAPYDRIIAACSVPQVPTGWLAQSRPGGVIL 212
Cdd:pfam01135 125 NvIVVVGDGRQGWPEFAPYDAIHVGAAAPEIPEALIDQLKEGGRLV 170
PRK13942 PRK13942
protein-L-isoaspartate O-methyltransferase; Provisional
 29-212 6.04e-27

protein-L-isoaspartate O-methyltransferase; Provisional


Pssm-ID: 184409  Cd Length: 212  Bit Score: 106.25  E-value: 6.04e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500899009  29 AFAAVPRHLFLtrffrqtPDRSRYEAvdvndlgaleliYSDRVLPTQldgddarwdesrhHGPlagvpTCSStqPALMAV 108
Cdd:PRK13942  27 ALLKVPRHLFV-------PEYLEEYA------------YVDTPLEIG-------------YGQ-----TISA--IHMVAI 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500899009 109 MLDALDVADGHRVLEVGTGTGYNAALLAHRLG-SPLVTTVDIDAGLVRRARQSLTSVGYAP-TVAATDGEAGYPGNAPYD 186
Cdd:PRK13942  68 MCELLDLKEGMKVLEIGTGSGYHAAVVAEIVGkSGKVVTIERIPELAEKAKKTLKKLGYDNvEVIVGDGTLGYEENAPYD 147

                        170       180
                 ....*....|....*....|....*.
gi 500899009 187 RIIAACSVPQVPTGWLAQSRPGGVIL 212
Cdd:PRK13942 148 RIYVTAAGPDIPKPLIEQLKDGGIMV 173
PRK13943 PRK13943
protein-L-isoaspartate O-methyltransferase; Provisional
 9-212 6.30e-24

protein-L-isoaspartate O-methyltransferase; Provisional


Pssm-ID: 237568 [Multi-domain]  Cd Length: 322  Bit Score: 100.69  E-value: 6.30e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500899009   9 RNRLVHELTGHGwLTEAWRTAFAAVPRHLFLTRFFrqtpdrsryeavdvndlgALELIYSDRVLPTQLDGDDarwdesrh 88
Cdd:PRK13943   7 REKLFWILKKYG-ISDHIAKAFLEVPREEFLTKSY------------------PLSYVYEDIVLVSYDDGEE-------- 59

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500899009  89 hgplagvpTCSSTQPALMAVMLDALDVADGHRVLEVGTGTGYNAALLAHRLGSP-LVTTVDIDAGLVRRARQSLTSVGYA 167
Cdd:PRK13943  60 --------YSTSSQPSLMALFMEWVGLDKGMRVLEIGGGTGYNAAVMSRVVGEKgLVVSVEYSRKICEIAKRNVRRLGIE 131

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 500899009 168 PTVAAT-DGEAGYPGNAPYDRIIAACSVPQVPTGWLAQSRPGGVIL 212
Cdd:PRK13943 132 NVIFVCgDGYYGVPEFAPYDVIFVTVGVDEVPETWFTQLKEGGRVI 177
PRK13944 PRK13944
protein-L-isoaspartate O-methyltransferase; Provisional
 8-250 5.05e-19

protein-L-isoaspartate O-methyltransferase; Provisional


Pssm-ID: 140001  Cd Length: 205  Bit Score: 84.48  E-value: 5.05e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500899009   8 ARNRLVHELTGHGWL-TEAWRTAFAAVPRHLFLTRFFRQtpdrsryeavdvndlgaleLIYSDRVLPTQLDGddarwdes 86
Cdd:PRK13944   1 MAKRLVEELVREGIIkSERVKKAMLSVPREEFVMPEYRM-------------------MAYEDRPLPLFAGA-------- 53

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500899009  87 rhhgplagvpTCSStqPALMAVMLDALDVADGHRVLEVGTGTGYNAALLAHRLGSP-LVTTVDIDAGLVRRARQSLTSVG 165
Cdd:PRK13944  54 ----------TISA--PHMVAMMCELIEPRPGMKILEVGTGSGYQAAVCAEAIERRgKVYTVEIVKELAIYAAQNIERLG 121

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500899009 166 YAPTVAA--TDGEAGYPGNAPYDRIIAACSVPQVPTGWLAQSRPGGVILTSLhREIGGGLLLRLTVDETGTASGHLldDY 243
Cdd:PRK13944 122 YWGVVEVyhGDGKRGLEKHAPFDAIIVTAAASTIPSALVRQLKDGGVLVIPV-EEGVGQVLYKVVKRGEKVEKRAI--TY 198


                 ....*..
gi 500899009 244 GSFMPLR 250
Cdd:PRK13944 199 VLFVPLR 205
pimt TIGR00080
protein-L-isoaspartate(D-aspartate) O-methyltransferase; This is an all-kingdom (but not all ...
 6-218 1.13e-18

protein-L-isoaspartate(D-aspartate) O-methyltransferase; This is an all-kingdom (but not all species) full-length ortholog enzyme for repairing aging proteins. Among the prokaryotes, the gene name is pcm. Among eukaryotes, pimt. [Protein fate, Protein modification and repair]


Pssm-ID: 272896 [Multi-domain]  Cd Length: 215  Bit Score: 83.72  E-value: 1.13e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500899009    6 ERARNRLVHELTGHGW-LTEAWRTAFAAVPRHLFLTRFFRQTPdrsrYeavdvnDLGALELIYSDRVlptqldgddarwd 84
Cdd:TIGR00080   4 ESQKKALIDKLINEGYiKSKRVIDALLSVPREEFVPEHFKEYA----Y------VDTPLEIGYGQTI------------- 60

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500899009   85 esrhhgplagvptcssTQPALMAVMLDALDVADGHRVLEVGTGTGYNAALLAHRLG-SPLVTTVDIDAGLVRRARQSLTS 163
Cdd:TIGR00080  61 ----------------SAPHMVAMMTELLELKPGMKVLEIGTGSGYQAAVLAEIVGrDGLVVSIERIPELAEKAERRLRK 124

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 500899009  164 VGYAPT-VAATDGEAGYPGNAPYDRIIAACSVPQVPTGWLAQSRPGGVILTSLHRE 218
Cdd:TIGR00080 125 LGLDNViVIVGDGTQGWEPLAPYDRIYVTAAGPKIPEALIDQLKEGGILVMPVGEY 180
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 109-214 3.20e-12

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 63.47  E-value: 3.20e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500899009 109 MLDALDVADGHRVLEVGTGTGYNAALLAHRLGSplVTTVDIDAGLVRRARQSLTSVGYAPTVAATDGEA-GYPgNAPYDR 187
Cdd:COG2226   14 LLAALGLRPGARVLDLGCGTGRLALALAERGAR--VTGVDISPEMLELARERAAEAGLNVEFVVGDAEDlPFP-DGSFDL 90

                         90       100       110
                 ....*....|....*....|....*....|...
gi 500899009 188 IIAACSVPQVP--TGWLAQS----RPGGVILTS 214
Cdd:COG2226   91 VISSFVLHHLPdpERALAEIarvlKPGGRLVVV 123
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 102-212 3.12e-10

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 58.40  E-value: 3.12e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500899009 102 QPALMAVMLDALDVADGHRVLEVGTGTGYNAALLAHRLGSpLVTTVDIDAGLVRRARQSLTSVGYAP--TVAATDGEAgY 179
Cdd:COG2230   36 QEAKLDLILRKLGLKPGMRVLDIGCGWGGLALYLARRYGV-RVTGVTLSPEQLEYARERAAEAGLADrvEVRLADYRD-L 113

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 500899009 180 PGNAPYDRIIAACSVPQVPTGWLAQS--------RPGGVIL 212
Cdd:COG2230  114 PADGQFDAIVSIGMFEHVGPENYPAYfakvarllKPGGRLL 154
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 121-209 3.60e-09

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 53.34  E-value: 3.60e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500899009  121 VLEVGTGTGYNAALLAHRLGSpLVTTVDIDAGLVRRARQSLTSVGYAPTVAATDGEAGYPGNAPYDRIIAACSVPQVPTG 200
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGA-RVTGVDLSPEMLERARERAAEAGLNVEFVQGDAEDLPFPDGSFDLVVSSGVLHHLPDP 79

                          90
                  ....*....|....*..
gi 500899009  201 WLAQS--------RPGG 209
Cdd:pfam13649  80 DLEAAlreiarvlKPGG 96
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
118-212 2.72e-08

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 50.98  E-value: 2.72e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500899009 118 GHRVLEVGTGTGYNAALLAHRLGSPLVTTVDIDAGLVRRARQSLTSVgyapTVAATDGEAgYPGNAPYDRIIAACS---V 194
Cdd:COG4106    2 PRRVLDLGCGTGRLTALLAERFPGARVTGVDLSPEMLARARARLPNV----RFVVADLRD-LDPPEPFDLVVSNAAlhwL 76

                         90       100
                 ....*....|....*....|.
gi 500899009 195 PQVPT---GWLAQSRPGGVIL 212
Cdd:COG4106   77 PDHAAllaRLAAALAPGGVLA 97
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 99-217 4.90e-07

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 49.91  E-value: 4.90e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500899009  99 SSTQPALMAVMLDALDVADGHRVLEVGTGTGYNAALLAHRLGSPlVTTVDIDAGLVRRARQSLTSVGYAP-TVAATD-GE 176
Cdd:COG0500    8 DELLPGLAALLALLERLPKGGRVLDLGCGTGRNLLALAARFGGR-VIGIDLSPEAIALARARAAKAGLGNvEFLVADlAE 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 500899009 177 AGYPGNAPYDRIIAACSV----PQVPTGWLA----QSRPGGVILTSLHR 217
Cdd:COG0500   87 LDPLPAESFDLVVAFGVLhhlpPEEREALLRelarALKPGGVLLLSASD 135
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 115-212 6.27e-07

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 48.09  E-value: 6.27e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500899009 115 VADGHRVLEVGTGTGYNAALLAhRLGSPlVTTVDIDAGLVRRARQSLTSVGyaPTVAATDGEAGYPGNAPYDRIIAACSV 194
Cdd:COG2227   22 LPAGGRVLDVGCGTGRLALALA-RRGAD-VTGVDISPEALEIARERAAELN--VDFVQGDLEDLPLEDGSFDLVICSEVL 97

                         90       100
                 ....*....|....*....|....
gi 500899009 195 PQV--PTGWLAQS----RPGGVIL 212
Cdd:COG2227   98 EHLpdPAALLRELarllKPGGLLL 121
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 120-215 1.30e-06

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 46.65  E-value: 1.30e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500899009 120 RVLEVGTGTGYNAALLAHRLGsPLVTTVDIDAGLVRRARQSLTSVGYAP-TVAATDGEAG-YPGNAPYDRII---AACSV 194
Cdd:cd02440    1 RVLDLGCGTGALALALASGPG-ARVTGVDISPVALELARKAAAALLADNvEVLKGDAEELpPEADESFDVIIsdpPLHHL 79

                         90       100
                 ....*....|....*....|....*
gi 500899009 195 PQVPTGWLAQ----SRPGGVILTSL 215
Cdd:cd02440   80 VEDLARFLEEarrlLKPGGVLVLTL 104
TrmR COG4122
tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; ...
 120-170 1.69e-06

tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; tRNA 5-hydroxyU34 O-methylase TrmR/YrrM is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443298  Cd Length: 173  Bit Score: 47.87  E-value: 1.69e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 500899009 120 RVLEVGTGTGYNAALLAHRLGSP-LVTTVDIDAGLVRRARQSLTSVGYAPTV 170
Cdd:COG4122   19 RILEIGTGTGYSTLWLARALPDDgRLTTIEIDPERAAIARENFARAGLADRI 70
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 107-161 3.83e-05

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 44.75  E-value: 3.83e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 500899009 107 AVML-DALDVADGHRVLEVGTGTGYNAALLAHRLGSPLVTTVDIDAGLVRRARQSL 161
Cdd:COG4123   26 AVLLaAFAPVKKGGRVLDLGTGTGVIALMLAQRSPGARITGVEIQPEAAELARRNV 81
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 107-189 8.58e-05

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 42.58  E-value: 8.58e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500899009  107 AVMLDALDVADGHRVLEVGTGTGYNAALLAHRLGSPLVTTVDIDAGLVRRARQSLTSVGYAPT-VAATDGEAGYPgNAPY 185
Cdd:pfam05175  21 RLLLEHLPKDLSGKVLDLGCGAGVLGAALAKESPDAELTMVDINARALESARENLAANGLENGeVVASDVYSGVE-DGKF 99


                  ....
gi 500899009  186 DRII 189
Cdd:pfam05175 100 DLII 103
PRK14968 PRK14968
putative methyltransferase; Provisional
 109-161 9.67e-05

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 42.96  E-value: 9.67e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 500899009 109 MLDALDVADGHRVLEVGTGTGYNAALLAHRLGSplVTTVDIDAGLVRRARQSL 161
Cdd:PRK14968  15 LAENAVDKKGDRVLEVGTGSGIVAIVAAKNGKK--VVGVDINPYAVECAKCNA 65
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 122-212 1.02e-04

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 40.73  E-value: 1.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500899009  122 LEVGTGTGYNAALLAHRlgSPLVTTVDIDAGLVRRARQSLTSVGYAPTVAatDGEA-GYPGNApYDRIIAACSVPQVPTG 200
Cdd:pfam08241   1 LDVGCGTGLLTELLARL--GARVTGVDISPEMLELAREKAPREGLTFVVG--DAEDlPFPDNS-FDLVLSSEVLHHVEDP 75

                          90
                  ....*....|....*...
gi 500899009  201 WLAQS------RPGGVIL 212
Cdd:pfam08241  76 ERALReiarvlKPGGILI 93
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
105-217 1.04e-04

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 42.68  E-value: 1.04e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500899009 105 LMAVMLDALDVADGHRVLEVGTGTGYNAALLAHRLGSplVTTVDIDAGLVRRARQSLTSVgyapTVAATDGEAGYPGNAP 184
Cdd:COG4976   34 LAEELLARLPPGPFGRVLDLGCGTGLLGEALRPRGYR--LTGVDLSEEMLAKAREKGVYD----RLLVADLADLAEPDGR 107

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 500899009 185 YDRIIAACSVPQVP-----TGWLAQS-RPGGVILTSLHR 217
Cdd:COG4976  108 FDLIVAADVLTYLGdlaavFAGVARAlKPGGLFIFSVED 146
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
100-165 2.14e-04

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 41.81  E-value: 2.14e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 500899009 100 STQPALMAVMLDALDVA---DGHRVLEVGTGTGYnAALLAHRLGSPLVTTVDIDAGLVRRARQSLTSVG 165
Cdd:COG2263   25 PTPAELAAELLHLAYLRgdiEGKTVLDLGCGTGM-LAIGAALLGAKKVVGVDIDPEALEIARENAERLG 92
PRK08317 PRK08317
hypothetical protein; Provisional
 110-159 8.01e-04

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 40.69  E-value: 8.01e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 500899009 110 LDALDVADGHRVLEVGTGTGYNAALLAHRLGSP-LVTTVDIDAGLVRRARQ 159
Cdd:PRK08317  12 FELLAVQPGDRVLDVGCGPGNDARELARRVGPEgRVVGIDRSEAMLALAKE 62
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 113-189 1.18e-03

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 40.14  E-value: 1.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500899009 113 LDVADGHRVLEVGTGTGYNAALLAHRLG-SPLVTTVDIDAGLVRRARQSLTSVGYAPTVAATDGEA--GYPGNaPYDRII 189
Cdd:COG2519   87 LDIFPGARVLEAGTGSGALTLALARAVGpEGKVYSYERREDFAEIARKNLERFGLPDNVELKLGDIreGIDEG-DVDAVF 165
hemK_rel_arch TIGR00537
HemK-related putative methylase; The gene hemK from E. coli was found to contribute to heme ...
 108-185 1.39e-03

HemK-related putative methylase; The gene hemK from E. coli was found to contribute to heme biosynthesis and originally suggested to be protoporphyrinogen oxidase. Functional analysis of the nearest homolog in Saccharomyces cerevisiae, YNL063w, finds it is not protoporphyrinogen oxidase and sequence analysis suggests that HemK homologs have S-adenosyl-methionine-dependent methyltransferase activity (Medline 99237242). Homologs are found, usually in a single copy, in nearly all completed genomes, but varying somewhat in apparent domain architecture. This model represents an archaeal and eukaryotic protein family that lacks an N-terminal domain found in HemK and its eubacterial homologs. It is found in a single copy in the first six completed archaeal and eukaryotic genomes. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 129628 [Multi-domain]  Cd Length: 179  Bit Score: 39.45  E-value: 1.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500899009  108 VMLDALDVADGHRVLEVGTGTGYNAALLAHRlgSPLVTTVDIDAGLVRRARQSLTSVGYAPTVAATDGEAGYPG------ 181
Cdd:TIGR00537  10 LLEANLRELKPDDVLEIGAGTGLVAIRLKGK--GKCILTTDINPFAVKELRENAKLNNVGLDVVMTDLFKGVRGkfdvil 87


                  ....*
gi 500899009  182 -NAPY 185
Cdd:TIGR00537  88 fNPPY 92
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 117-167 1.46e-03

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 38.94  E-value: 1.46e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 500899009  117 DGHRVLEVGTGTGYNAALLAHRLGSPL-VTTVDIDAGLVRRARQSLTSVGYA 167
Cdd:pfam13847   3 KGMRVLDLGCGTGHLSFELAEELGPNAeVVGIDISEEAIEKARENAQKLGFD 54
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 122-211 1.99e-03

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 37.35  E-value: 1.99e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500899009  122 LEVGTGTGYNAALLAHRLGSPLVTTVDIDAGLVRRARQSLTSVGY--APTVAATDGEAGYPGNAPYDRIIAACSV--PQV 197
Cdd:pfam08242   1 LEIGCGTGTLLRALLEALPGLEYTGLDISPAALEAARERLAALGLlnAVRVELFQLDLGELDPGSFDVVVASNVLhhLAD 80

                          90
                  ....*....|....*...
gi 500899009  198 PTGWLAQSR----PGGVI 211
Cdd:pfam08242  81 PRAVLRNIRrllkPGGVL 98
PRK14967 PRK14967
putative methyltransferase; Provisional
 105-199 2.17e-03

putative methyltransferase; Provisional


Pssm-ID: 184931 [Multi-domain]  Cd Length: 223  Bit Score: 39.27  E-value: 2.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500899009 105 LMAVMLDALDVADGHRVLEVGTGTGYnAALLAHRLGSPLVTTVDIDAGLVRRARQSLTSVGYAPTVAATDGEAGYPGNaP 184
Cdd:PRK14967  24 LLADALAAEGLGPGRRVLDLCTGSGA-LAVAAAAAGAGSVTAVDISRRAVRSARLNALLAGVDVDVRRGDWARAVEFR-P 101

                         90
                 ....*....|....*
gi 500899009 185 YDRIIaaCSVPQVPT 199
Cdd:PRK14967 102 FDVVV--SNPPYVPA 114
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 107-189 2.71e-03

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 38.63  E-value: 2.71e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500899009 107 AVMLDALDVADGHRVLEVGTGTGYNAALLAHRLGSPLVTTVDIDAGLVRRARQSLTSVGYAP-TVAATDGEAGYPGnAPY 185
Cdd:COG2813   39 RLLLEHLPEPLGGRVLDLGCGYGVIGLALAKRNPEARVTLVDVNARAVELARANAAANGLENvEVLWSDGLSGVPD-GSF 117


                 ....
gi 500899009 186 DRII 189
Cdd:COG2813  118 DLIL 121
PrmA COG2264
Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];
104-190 3.61e-03

Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441865 [Multi-domain]  Cd Length: 284  Bit Score: 39.00  E-value: 3.61e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500899009 104 ALMAVMLDALDVAdGHRVLEVGTGTGynaALLAHRLGSPLVTTVDIDAGLVRRARQ--SLTSVGYAPTVAATDGEAgypg 181
Cdd:COG2264  136 RLCLEALEKLLKP-GKTVLDVGCGSGi-lAIAAAKLGAKRVLAVDIDPVAVEAAREnaELNGVEDRIEVVLGDLLE---- 209


                 ....*....
gi 500899009 182 NAPYDRIIA 190
Cdd:COG2264  210 DGPYDLVVA 218
RsmA COG0030
16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase ...
 109-159 5.33e-03

16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) [Translation, ribosomal structure and biogenesis]; 16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 439801 [Multi-domain]  Cd Length: 270  Bit Score: 38.18  E-value: 5.33e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 500899009 109 MLDALDVADGHRVLEVGTGTGynaAL---LAHRLGSplVTTVDIDAGLVRRARQ 159
Cdd:COG0030   29 IVDAAGITPGDTVLEIGPGLG---ALtraLLERAAR--VTAVEIDRRLAAILRE 77
DUF938 pfam06080
Protein of unknown function (DUF938); This family consists of several hypothetical proteins ...
 96-191 6.15e-03

Protein of unknown function (DUF938); This family consists of several hypothetical proteins from both prokaryotes and eukaryotes. The function of this family is unknown.


Pssm-ID: 253548  Cd Length: 201  Bit Score: 37.44  E-value: 6.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500899009   96 PTCSSTQPALMAVMLDALDvADGHRVLEVGTGTGYNAALLAHRLGSPLVTTVDID----AGLVRRARQSLTSVGYAPT-- 169
Cdd:pfam06080   5 PAAERNREPILSVLQSYFA-KTTERVLEIASGTGQHAVFFAPLLPNLTWQPSDPDpnlrGSIAAWADQQGLRNLRPPLhl 83

                          90       100
                  ....*....|....*....|...
gi 500899009  170 -VAATDGEAGYPGNAPYDRIIAA 191
Cdd:pfam06080  84 dVTRPPWPVEAPAPASYDAIFSI 106
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 109-170 9.31e-03

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 37.44  E-value: 9.31e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 500899009 109 MLDALDVADGHRVLEVGTGTGYNAALLAHRLGSPL-VTTVDIDAGLVRRARQSLTSVGYAPTV 170
Cdd:PRK00216  43 TIKWLGVRPGDKVLDLACGTGDLAIALAKAVGKTGeVVGLDFSEGMLAVGREKLRDLGLSGNV 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH