|
Name |
Accession |
Description |
Interval |
E-value |
| PRK05321 |
PRK05321 |
nicotinate phosphoribosyltransferase; Provisional |
6-395 |
0e+00 |
|
nicotinate phosphoribosyltransferase; Provisional
Pssm-ID: 235406 [Multi-domain] Cd Length: 400 Bit Score: 731.56 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500920205 6 FAERIVQNLLDTDFYKLTMMQAVLHNYPNAEVEWEFRCRSSE-DLTPYLAEIRYQIERLSELSITADQLAFLERIPFIKP 84
Cdd:PRK05321 4 KADPIIRSLLDTDFYKLTMQQAVLHHYPDAQVEYEFICRNDEvDLAEYIDEIREQLDHLCTLRLTDDELDYLRGLPFFKP 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500920205 85 DFIRFLSLFRFNLRYVHTGIEDGQLSIRLRGPWLHVILFEVPLLAIVSEVRNRYRYREVLLEQAAERLYQKLDWLRAEas 164
Cdd:PRK05321 84 DFLDWLRLFRLNPYEVTVSIDDGQLDIRIEGPWLETILWEVPLLAIISELYFRARSPEVLYAQAKRRLWEKIELLKAL-- 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500920205 165 eDELAGFQLADFGTRRRFSYRVQEQAVHILKRDFPGRFVGTSNVHLAREFDLKPIGTMAHEWLMAHQQLGPRLIDSQIAA 244
Cdd:PRK05321 162 -PDLSGFKIADFGTRRRFSFEWQEEVVEALKEGLPGAFVGTSNVHLAMKLGLTPIGTMAHEWFMAHQALGPRLRDSQYAA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500920205 245 LDCWVREYRGQLGIALTDCITMDAFLADFDLYFAKLFDGLRHDSGDPLEWAEKAIAHYEKLGIDPLSKTLVFSDGLDLPK 324
Cdd:PRK05321 241 LEDWVREYRGDLGIALTDTIGMDAFLRDFDLYFAKLFDGLRHDSGDPIEWGEKAIAHYEKLGIDPRTKTLVFSDGLDFDK 320
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 500920205 325 SLRLYRALSGRIHVSFGVGTNLTCDIPGVEPMNIVIKMIACNGQPVAKISDTPGKTQCRDENFVSYLKHVF 395
Cdd:PRK05321 321 ALELYRHFKGRIKLSFGIGTNLTNDFPGVKPLNIVIKLVECNGRPVAKLSDSPGKTMCDDPEFLRYLRQVF 391
|
|
| PncB_like |
cd01401 |
Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate ... |
12-380 |
0e+00 |
|
Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products. This subgroup is present in bacteria, archea and funghi.
Pssm-ID: 238695 [Multi-domain] Cd Length: 377 Bit Score: 598.08 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500920205 12 QNLLDTDFYKLTMMQAVLHNYPNAEVEWEFRCRSSEDLT-PYLAEIRYQIERLSELSITADQLAFLER-IPFIKPDFIRF 89
Cdd:cd01401 1 RSLLDTDLYKLTMQQAVLHHYPDVQVTYEFTNRSPEDFLeEAAEALREQIDHLANLRFSEEELAYLRRsLPFLKPDYLDY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500920205 90 LSLFRFNLRYV--HTGIEDGQLSIRLRGPWLHVILFEVPLLAIVSEVRNRYRYREVLLEQAAERLYQKLDWLRAEASEDE 167
Cdd:cd01401 81 LELFRLNPEEVvvRLDTGKGQLDIRISGPWKDTILYEVPLLAIVSEVYFRFRDADWDYEEQLEKLEEKLERLLEEAKRRD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500920205 168 LAGFQLADFGTRRRFSYRVQEQAVHILKRDFPGRFVGTSNVHLAREFDLKPIGTMAHEWLMAHQQLGPRLIDSQIAALDC 247
Cdd:cd01401 161 LNGFRFSDFGTRRRFSYEVQETVLKGLKQAAPGYLTGTSNVHFAMKYGLTPIGTVAHEWFMAHQALTGDLKDSQKAALER 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500920205 248 WVREYRGQLGIALTDCITMDAFLADFDLYFAKLFDGLRHDSGDPLEWAEKAIAHYEKLGIDPLSKTLVFSDGLDLPKSLR 327
Cdd:cd01401 241 WVREYGGDLGIALTDTFGTDAFLRDFDLYFAKLFDGVRHDSGDPFEWGEKAIAHYEKLGIDPKTKTLVFSDGLDVEKALE 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 500920205 328 LYRALSGRIHVSFGVGTNLTCDIP---GVEPMNIVIKMIACNGQPVAKISDTPGKT 380
Cdd:cd01401 321 LYEYFKGRIKVSFGIGTNLTNDFGnkeKSTPLNIVIKLVECNGRPVAKISDSPGKN 376
|
|
| NAPRTase |
TIGR01514 |
nicotinate phosphoribosyltransferase; This model represents nicotinate ... |
10-395 |
1.42e-172 |
|
nicotinate phosphoribosyltransferase; This model represents nicotinate phosphoribosyltransferase, the first enzyme in the salvage pathway of NAD biosynthesis from nicontinate (niacin). Members are primary proteobacterial but also include yeasts and Methanosarcina acetivorans. A related family, apparently non-overlapping in species distribution, is TIGR01513. Members of that family differ in substantially in sequence and have a long C-terminal extension missing from this family, but are proposed also to act as nicotinate phosphoribosyltransferase (see model TIGR01513). [Biosynthesis of cofactors, prosthetic groups, and carriers, Pyridine nucleotides]
Pssm-ID: 130578 [Multi-domain] Cd Length: 394 Bit Score: 487.34 E-value: 1.42e-172
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500920205 10 IVQNLLDTDFYKLTMMQAVLHNYPNAEVEWEFRCRSSEDLTPYLAE-IRYQIERLSELSITADQLAFLER-IPFIKPDFI 87
Cdd:TIGR01514 1 IIRSLLDTDLYKITMHQAVFHNFPDVHVTYEFICRSSQLFLKEAAEaLREEISALGNLRFTDDEIEYLKQeLPYLKSDYI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500920205 88 RFLSLFRFN-LRYVHTGIED-GQLSIRLRGPWLHVILFEVPLLAIVSEVRNRYRYREVLLEQAAERLYQKLDWLRAEASE 165
Cdd:TIGR01514 81 DYLRNFRFHpEEQVEVGIDDkGKLDIRISGSWRDTILYEIPLLAIISELYFRFRDAEADYEQQLEVLESKLDQLKAEIAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500920205 166 DEL--AGFQLADFGTRRRFSYRVQEQAVHILKRDFPGRFVGTSNVHLAREFDLKPIGTMAHEWLMAHQQLGPrLIDSQIA 243
Cdd:TIGR01514 161 ETMfeNGFRFSEFGTRRRFSLEVQDLVTQGLKQAAPSWLLGTSNVHLAKKLGLKPIGTVAHEWFQGHQAISE-YRNAQKV 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500920205 244 ALDCWVREYRGQLGIALTDCITMDAFLADFDLYFAKLFDGLRHDSGDPLEWAEKAIAHYEKLGIDPLSKTLVFSDGLDLP 323
Cdd:TIGR01514 240 ALECWINEYDGDLGIALTDTFTTDAFLRDFRPPFADAYDGLRHDSGDPVEWGDKAIAHYQKLGIDPKSKIIIFSDSLDVE 319
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 500920205 324 KSLRLYRALSGRIHVSFGVGTNLTCDIPGVEPMNIVIKMIACNGQPVAKISDTPGKTQCRDENFVSYLKHVF 395
Cdd:TIGR01514 320 KAIELSHYFKGRVKASFGIGTNLTNDFGKVEPLNIVIKLVECNGNPVAKLSDSPGKTMGEPATFLRALRELF 391
|
|
| NAPRTase |
pfam04095 |
Nicotinate phosphoribosyltransferase (NAPRTase) family; Nicotinate phosphoribosyltransferase ... |
171-398 |
6.47e-117 |
|
Nicotinate phosphoribosyltransferase (NAPRTase) family; Nicotinate phosphoribosyltransferase (EC:2.4.2.11) is the rate limiting enzyme that catalyzes the first reaction in the NAD salvage synthesis. This family also includes Pre-B cell enhancing factor that is a cytokine Swiss:P43490. This family is related to Quinolinate phosphoribosyltransferase pfam01729.
Pssm-ID: 397974 [Multi-domain] Cd Length: 235 Bit Score: 339.74 E-value: 6.47e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500920205 171 FQLADFGTRRRFSYRVQEqavHILKRdFPGRFVGTSNVHLAREFDLKPIGTMAHEWLMAHQQLGPRLIDSQIAALDCWVR 250
Cdd:pfam04095 1 FKLHDFGTRRRSSLESQE---IVGLA-HLVNFLGTSNVHFAAKYSIPPAGTSAHEWWGAHQELDANLRQFQKDALDLWHA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500920205 251 EYRGQLGIALTDCITMDAFLADFDLYFAKLFDGLRHDSGDPLEWAEKAIAHYEKL-GIDPLSKTLVFSDGLDLPKSLRLY 329
Cdd:pfam04095 77 EYRGNLGIALTDTVTMDAFLKDFDLYFAKLYLGVRPDSGDPVEWGEKLIAHYGSTlNIDGYTKRLIFSDGLDVEKIIELL 156
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 500920205 330 RALSG-RIHVSFGVGTNLTCDIPG--------VEPMNIVIKMIACNGQPVAKISDTPGKTQCRDENFVSYLKHVFRVT 398
Cdd:pfam04095 157 EYFKGkGFNIAFGIGTNLTQDLNRdtlgfavkATPLNIVIKLVEVNGDPVAKISDSSGKGRCGDPAFVALLRTVFDNG 234
|
|
| PncB |
COG1488 |
Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid ... |
14-396 |
1.17e-44 |
|
Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid phosphoribosyltransferase is part of the Pathway/BioSystem: NAD biosynthesis
Pssm-ID: 441097 [Multi-domain] Cd Length: 445 Bit Score: 160.31 E-value: 1.17e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500920205 14 LLDTDFYKLTMMQAVLHN-YPNAEVEWEFRCRSSEDLTPYL--AEIRYQIERLSELSITADQLAFLERIPFIKPDFIRFL 90
Cdd:COG1488 5 ALLTDLYKLTMAQAYLPEgTANRRAVFELFFRRLPFGRGYVvfAGLQRFLKYLENLRFTEEDIAYLRSLGVFDEDFLDYL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500920205 91 SLFRFNLRyVHtGIEDGQLS------IRLRGPWLHVILFEVPLLAIVSE------VRNRYRyrevlleQAAErlyqkldw 158
Cdd:COG1488 85 ADFRFPGD-IR-AVPEGTVVfpgeplLTVEGTLPEAQLLETLLLNILNYptliatKAARIV-------QAAG-------- 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500920205 159 lraeasedelaGFQLADFGTRRRFSyrvQEQAVHIlkrdfpGR------FVGTSNVHLAREFDLKPIGTMAHEWLMAHqq 232
Cdd:COG1488 148 -----------GRPLHDFGLRRAHG---LEAAVAA------ARaaylagFAGTSNVLAGRYYGIPSVGTMAHSFVQAH-- 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500920205 233 lgprliDSQIAALDCWVREYRGQLgIALTDciTMDAF--------LADfDLYFAKLFDGLRHDSGDPLEWAEKAIAHYEK 304
Cdd:COG1488 206 ------DDELEAFRAFAEAYPDGT-TLLVD--TYDTLsgvpnaieLAK-ELLARGGLLGIRLDSGDLAYLSKQARELLDE 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500920205 305 LGIDplSKTLVFSDGLDLPKSLRLYRAlSGRIHVsFGVGTNL----TCDIPGvepmnIVIKMIACNG----QPVAKISDT 376
Cdd:COG1488 276 AGLP--DVRIIASDDLDEYRIAALLEQ-GAPIDV-FGVGTRLvtssDRPTLG-----FVYKLVAVEGdgewRPVIKLSET 346
|
410 420
....*....|....*....|
gi 500920205 377 PGKTQCRdenfvsYLKHVFR 396
Cdd:COG1488 347 PGKKSKP------GRKQVYR 360
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK05321 |
PRK05321 |
nicotinate phosphoribosyltransferase; Provisional |
6-395 |
0e+00 |
|
nicotinate phosphoribosyltransferase; Provisional
Pssm-ID: 235406 [Multi-domain] Cd Length: 400 Bit Score: 731.56 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500920205 6 FAERIVQNLLDTDFYKLTMMQAVLHNYPNAEVEWEFRCRSSE-DLTPYLAEIRYQIERLSELSITADQLAFLERIPFIKP 84
Cdd:PRK05321 4 KADPIIRSLLDTDFYKLTMQQAVLHHYPDAQVEYEFICRNDEvDLAEYIDEIREQLDHLCTLRLTDDELDYLRGLPFFKP 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500920205 85 DFIRFLSLFRFNLRYVHTGIEDGQLSIRLRGPWLHVILFEVPLLAIVSEVRNRYRYREVLLEQAAERLYQKLDWLRAEas 164
Cdd:PRK05321 84 DFLDWLRLFRLNPYEVTVSIDDGQLDIRIEGPWLETILWEVPLLAIISELYFRARSPEVLYAQAKRRLWEKIELLKAL-- 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500920205 165 eDELAGFQLADFGTRRRFSYRVQEQAVHILKRDFPGRFVGTSNVHLAREFDLKPIGTMAHEWLMAHQQLGPRLIDSQIAA 244
Cdd:PRK05321 162 -PDLSGFKIADFGTRRRFSFEWQEEVVEALKEGLPGAFVGTSNVHLAMKLGLTPIGTMAHEWFMAHQALGPRLRDSQYAA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500920205 245 LDCWVREYRGQLGIALTDCITMDAFLADFDLYFAKLFDGLRHDSGDPLEWAEKAIAHYEKLGIDPLSKTLVFSDGLDLPK 324
Cdd:PRK05321 241 LEDWVREYRGDLGIALTDTIGMDAFLRDFDLYFAKLFDGLRHDSGDPIEWGEKAIAHYEKLGIDPRTKTLVFSDGLDFDK 320
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 500920205 325 SLRLYRALSGRIHVSFGVGTNLTCDIPGVEPMNIVIKMIACNGQPVAKISDTPGKTQCRDENFVSYLKHVF 395
Cdd:PRK05321 321 ALELYRHFKGRIKLSFGIGTNLTNDFPGVKPLNIVIKLVECNGRPVAKLSDSPGKTMCDDPEFLRYLRQVF 391
|
|
| PncB_like |
cd01401 |
Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate ... |
12-380 |
0e+00 |
|
Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products. This subgroup is present in bacteria, archea and funghi.
Pssm-ID: 238695 [Multi-domain] Cd Length: 377 Bit Score: 598.08 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500920205 12 QNLLDTDFYKLTMMQAVLHNYPNAEVEWEFRCRSSEDLT-PYLAEIRYQIERLSELSITADQLAFLER-IPFIKPDFIRF 89
Cdd:cd01401 1 RSLLDTDLYKLTMQQAVLHHYPDVQVTYEFTNRSPEDFLeEAAEALREQIDHLANLRFSEEELAYLRRsLPFLKPDYLDY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500920205 90 LSLFRFNLRYV--HTGIEDGQLSIRLRGPWLHVILFEVPLLAIVSEVRNRYRYREVLLEQAAERLYQKLDWLRAEASEDE 167
Cdd:cd01401 81 LELFRLNPEEVvvRLDTGKGQLDIRISGPWKDTILYEVPLLAIVSEVYFRFRDADWDYEEQLEKLEEKLERLLEEAKRRD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500920205 168 LAGFQLADFGTRRRFSYRVQEQAVHILKRDFPGRFVGTSNVHLAREFDLKPIGTMAHEWLMAHQQLGPRLIDSQIAALDC 247
Cdd:cd01401 161 LNGFRFSDFGTRRRFSYEVQETVLKGLKQAAPGYLTGTSNVHFAMKYGLTPIGTVAHEWFMAHQALTGDLKDSQKAALER 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500920205 248 WVREYRGQLGIALTDCITMDAFLADFDLYFAKLFDGLRHDSGDPLEWAEKAIAHYEKLGIDPLSKTLVFSDGLDLPKSLR 327
Cdd:cd01401 241 WVREYGGDLGIALTDTFGTDAFLRDFDLYFAKLFDGVRHDSGDPFEWGEKAIAHYEKLGIDPKTKTLVFSDGLDVEKALE 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 500920205 328 LYRALSGRIHVSFGVGTNLTCDIP---GVEPMNIVIKMIACNGQPVAKISDTPGKT 380
Cdd:cd01401 321 LYEYFKGRIKVSFGIGTNLTNDFGnkeKSTPLNIVIKLVECNGRPVAKISDSPGKN 376
|
|
| NAPRTase |
TIGR01514 |
nicotinate phosphoribosyltransferase; This model represents nicotinate ... |
10-395 |
1.42e-172 |
|
nicotinate phosphoribosyltransferase; This model represents nicotinate phosphoribosyltransferase, the first enzyme in the salvage pathway of NAD biosynthesis from nicontinate (niacin). Members are primary proteobacterial but also include yeasts and Methanosarcina acetivorans. A related family, apparently non-overlapping in species distribution, is TIGR01513. Members of that family differ in substantially in sequence and have a long C-terminal extension missing from this family, but are proposed also to act as nicotinate phosphoribosyltransferase (see model TIGR01513). [Biosynthesis of cofactors, prosthetic groups, and carriers, Pyridine nucleotides]
Pssm-ID: 130578 [Multi-domain] Cd Length: 394 Bit Score: 487.34 E-value: 1.42e-172
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500920205 10 IVQNLLDTDFYKLTMMQAVLHNYPNAEVEWEFRCRSSEDLTPYLAE-IRYQIERLSELSITADQLAFLER-IPFIKPDFI 87
Cdd:TIGR01514 1 IIRSLLDTDLYKITMHQAVFHNFPDVHVTYEFICRSSQLFLKEAAEaLREEISALGNLRFTDDEIEYLKQeLPYLKSDYI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500920205 88 RFLSLFRFN-LRYVHTGIED-GQLSIRLRGPWLHVILFEVPLLAIVSEVRNRYRYREVLLEQAAERLYQKLDWLRAEASE 165
Cdd:TIGR01514 81 DYLRNFRFHpEEQVEVGIDDkGKLDIRISGSWRDTILYEIPLLAIISELYFRFRDAEADYEQQLEVLESKLDQLKAEIAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500920205 166 DEL--AGFQLADFGTRRRFSYRVQEQAVHILKRDFPGRFVGTSNVHLAREFDLKPIGTMAHEWLMAHQQLGPrLIDSQIA 243
Cdd:TIGR01514 161 ETMfeNGFRFSEFGTRRRFSLEVQDLVTQGLKQAAPSWLLGTSNVHLAKKLGLKPIGTVAHEWFQGHQAISE-YRNAQKV 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500920205 244 ALDCWVREYRGQLGIALTDCITMDAFLADFDLYFAKLFDGLRHDSGDPLEWAEKAIAHYEKLGIDPLSKTLVFSDGLDLP 323
Cdd:TIGR01514 240 ALECWINEYDGDLGIALTDTFTTDAFLRDFRPPFADAYDGLRHDSGDPVEWGDKAIAHYQKLGIDPKSKIIIFSDSLDVE 319
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 500920205 324 KSLRLYRALSGRIHVSFGVGTNLTCDIPGVEPMNIVIKMIACNGQPVAKISDTPGKTQCRDENFVSYLKHVF 395
Cdd:TIGR01514 320 KAIELSHYFKGRVKASFGIGTNLTNDFGKVEPLNIVIKLVECNGNPVAKLSDSPGKTMGEPATFLRALRELF 391
|
|
| NAPRTase |
pfam04095 |
Nicotinate phosphoribosyltransferase (NAPRTase) family; Nicotinate phosphoribosyltransferase ... |
171-398 |
6.47e-117 |
|
Nicotinate phosphoribosyltransferase (NAPRTase) family; Nicotinate phosphoribosyltransferase (EC:2.4.2.11) is the rate limiting enzyme that catalyzes the first reaction in the NAD salvage synthesis. This family also includes Pre-B cell enhancing factor that is a cytokine Swiss:P43490. This family is related to Quinolinate phosphoribosyltransferase pfam01729.
Pssm-ID: 397974 [Multi-domain] Cd Length: 235 Bit Score: 339.74 E-value: 6.47e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500920205 171 FQLADFGTRRRFSYRVQEqavHILKRdFPGRFVGTSNVHLAREFDLKPIGTMAHEWLMAHQQLGPRLIDSQIAALDCWVR 250
Cdd:pfam04095 1 FKLHDFGTRRRSSLESQE---IVGLA-HLVNFLGTSNVHFAAKYSIPPAGTSAHEWWGAHQELDANLRQFQKDALDLWHA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500920205 251 EYRGQLGIALTDCITMDAFLADFDLYFAKLFDGLRHDSGDPLEWAEKAIAHYEKL-GIDPLSKTLVFSDGLDLPKSLRLY 329
Cdd:pfam04095 77 EYRGNLGIALTDTVTMDAFLKDFDLYFAKLYLGVRPDSGDPVEWGEKLIAHYGSTlNIDGYTKRLIFSDGLDVEKIIELL 156
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 500920205 330 RALSG-RIHVSFGVGTNLTCDIPG--------VEPMNIVIKMIACNGQPVAKISDTPGKTQCRDENFVSYLKHVFRVT 398
Cdd:pfam04095 157 EYFKGkGFNIAFGIGTNLTQDLNRdtlgfavkATPLNIVIKLVEVNGDPVAKISDSSGKGRCGDPAFVALLRTVFDNG 234
|
|
| NAPRTase_PncB |
cd01567 |
Nicotinate phosphoribosyltransferase (NAPRTase) family. Nicotinate phosphoribosyltransferase ... |
14-361 |
2.72e-110 |
|
Nicotinate phosphoribosyltransferase (NAPRTase) family. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products.
Pssm-ID: 238801 [Multi-domain] Cd Length: 343 Bit Score: 326.92 E-value: 2.72e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500920205 14 LLDTDFYKLTMMQAVLHNYPNAEVEWEFRCRSSEDLTPY--LAEIRYQIERLSELSITADQLAFL----------ERIPF 81
Cdd:cd01567 1 LLDTDLYKLTMMQAYLYPYPNTRVVFEFTFRSNPFGGDYivFAGLEEVLKLLENLRFTEEEIEYLkkllifgeffLYLLF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500920205 82 IKPDFIRFLSLFRFNLRYVHtgiedgQLSIRLRGPWLHVILFEVPLLAIVSEVRNRYRYREVLLEQAAERLYQKLdwlra 161
Cdd:cd01567 81 LGKLPLEIYALPEGTVVFPK------EPLLTIEGPWPEAGLLETPLLAIWNEATSIATKAARKKLAAGGLLETKD----- 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500920205 162 easEDELAGFQLADFGTRRRFSYrvqEQAVHILKRDFPGRFVGTSNVHLAREFDLKPIGTMAHEWLMAHQQLgprlIDSQ 241
Cdd:cd01567 150 ---NLEELGFKLHDFGTRRRHSP---EAALSGGRAALIGGFGGTSNVAAAKKLGIPPIGTMAHSWIQAFGAL----EEAA 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500920205 242 IAALDCWVREYRGQLGIALTDCITMD-AFLADFDLYFAKL----FDGLRHDSGDPLEWAEKAIAHYEKLGIDPLSKTLVF 316
Cdd:cd01567 220 FEAFARWLPQFGGGLGIALIDTYDTDnGFLNALKLAKALGagggLLGVRLDSGDPVELIKKVRKHLDELGIDLNKKKIII 299
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 500920205 317 SDGLDLPKSLRLYRALSGRIHVSFGVGTNLTCDIpGVEPMNIVIK 361
Cdd:cd01567 300 SGDLDTEEAIELLLEQGASPNDAFGVGTSLTNDL-GRPPLGFVYK 343
|
|
| PRTase_typeII |
cd00516 |
Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an ... |
18-361 |
1.08e-54 |
|
Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate phosphoribosyltransferase (NAPRTase), to be used in the synthesis of NAD. QAPRTase catalyses the reaction of quinolinic acid (QA) with 5-phosphoribosyl-1-pyrophosphate (PRPP) in the presence of Mg2+ to produce nicotinic acid mononucleotide (NAMN), pyrophosphate and carbon dioxide, an important step in the de novo synthesis of NAD. NAPRTase catalyses a similar reaction leading to NAMN and pyrophosphate, using nicotinic acid an PPRP as substrates, used in the NAD salvage pathway.
Pssm-ID: 238286 [Multi-domain] Cd Length: 281 Bit Score: 182.05 E-value: 1.08e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500920205 18 DFYKLTMMQAvlHNYPNAEVEWEFRCRSSEDLtpYLAEIRYQIERLSELSItadqlafleripfikPDFIRFLSLFRFNL 97
Cdd:cd00516 1 DLYKLTMIQA--YPPPDTRATAEFTAREDPYG--VLAGLEEALELLELLRF---------------PGPLVILAVPEGTV 61
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500920205 98 ryvhtgIEDGQLSIRLRGPWLHVILFEVPLLAIVSEVRNRYRYREVLLEQAAErlyqkldwlraeasedelAGFQLADFG 177
Cdd:cd00516 62 ------VEPGEPLLTIEGPARELLLLERVLLNLLQRLSGIATATARYVEAAKG------------------ANTKVHDFG 117
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500920205 178 TRRRFSY-RVQE-QAVHIlkrdfpGRFVGTSNVHLAREFDLKPIGTMAHEWLMAHqqlgprLIDSQIAALDCWVreyrGQ 255
Cdd:cd00516 118 TRKTTPGlRLLEkYAVLI------GGGDGHRNGLSDAILIKDNHGTMAHSIIQAF------GELAAVKALRRWL----PE 181
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500920205 256 LGIALTDCITMDaFLADFDLYFAKLFDGLRHDSG-----DPLEWAEKAIAHYEklGIDPLSKTLVFSDGLDLpKSLRLYR 330
Cdd:cd00516 182 LFIALIDVEVDT-LEEALEAAKAGGADGIRLDSGspeelDPAVLILKARAHLD--GKGLPRVKIEASGGLDE-ENIRAYA 257
|
330 340 350
....*....|....*....|....*....|.
gi 500920205 331 AlSGRIhvSFGVGTNLTCDipgvEPMNIVIK 361
Cdd:cd00516 258 E-TGVD--VFGVGTLLHSA----PPLDIVLK 281
|
|
| PncB |
COG1488 |
Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid ... |
14-396 |
1.17e-44 |
|
Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid phosphoribosyltransferase is part of the Pathway/BioSystem: NAD biosynthesis
Pssm-ID: 441097 [Multi-domain] Cd Length: 445 Bit Score: 160.31 E-value: 1.17e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500920205 14 LLDTDFYKLTMMQAVLHN-YPNAEVEWEFRCRSSEDLTPYL--AEIRYQIERLSELSITADQLAFLERIPFIKPDFIRFL 90
Cdd:COG1488 5 ALLTDLYKLTMAQAYLPEgTANRRAVFELFFRRLPFGRGYVvfAGLQRFLKYLENLRFTEEDIAYLRSLGVFDEDFLDYL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500920205 91 SLFRFNLRyVHtGIEDGQLS------IRLRGPWLHVILFEVPLLAIVSE------VRNRYRyrevlleQAAErlyqkldw 158
Cdd:COG1488 85 ADFRFPGD-IR-AVPEGTVVfpgeplLTVEGTLPEAQLLETLLLNILNYptliatKAARIV-------QAAG-------- 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500920205 159 lraeasedelaGFQLADFGTRRRFSyrvQEQAVHIlkrdfpGR------FVGTSNVHLAREFDLKPIGTMAHEWLMAHqq 232
Cdd:COG1488 148 -----------GRPLHDFGLRRAHG---LEAAVAA------ARaaylagFAGTSNVLAGRYYGIPSVGTMAHSFVQAH-- 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500920205 233 lgprliDSQIAALDCWVREYRGQLgIALTDciTMDAF--------LADfDLYFAKLFDGLRHDSGDPLEWAEKAIAHYEK 304
Cdd:COG1488 206 ------DDELEAFRAFAEAYPDGT-TLLVD--TYDTLsgvpnaieLAK-ELLARGGLLGIRLDSGDLAYLSKQARELLDE 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500920205 305 LGIDplSKTLVFSDGLDLPKSLRLYRAlSGRIHVsFGVGTNL----TCDIPGvepmnIVIKMIACNG----QPVAKISDT 376
Cdd:COG1488 276 AGLP--DVRIIASDDLDEYRIAALLEQ-GAPIDV-FGVGTRLvtssDRPTLG-----FVYKLVAVEGdgewRPVIKLSET 346
|
410 420
....*....|....*....|
gi 500920205 377 PGKTQCRdenfvsYLKHVFR 396
Cdd:COG1488 347 PGKKSKP------GRKQVYR 360
|
|
| NAPRTase_N |
pfam17767 |
Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain; Nicotinate ... |
15-132 |
5.39e-42 |
|
Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain; Nicotinate phosphoribosyltransferase (EC:2.4.2.11) is the rate limiting enzyme that catalyzes the first reaction in the NAD salvage synthesis. This is the N-terminal domain of the enzyme.
Pssm-ID: 465494 [Multi-domain] Cd Length: 125 Bit Score: 143.81 E-value: 5.39e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500920205 15 LDTDFYKLTMMQAVLHNYPNAEVEWEFRCRSS--EDLTPYLAEIRYQIERLSELSITADQLAFLER-IPFIKPDFIRFLS 91
Cdd:pfam17767 1 LDTDLYKLTMAQAYFKNGPDVQVVFEFFNRTNpfGGLYAVFAGLEEQIEFLENLRFTEEEIEYLRRsLPYFKPDFLDYLR 80
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 500920205 92 LFRFNLRYVH----TGIEDGQLSIRLRGPWLHVILFEVPLLAIVS 132
Cdd:pfam17767 81 NFRFDPSIVAvpegEVVFPGEPLLRIEGPWLETILLETPLLAIVN 125
|
|
| NAPRTase_put |
TIGR01513 |
putative nicotinate phosphoribosyltransferase; A deep split separates two related families of ... |
15-399 |
1.41e-34 |
|
putative nicotinate phosphoribosyltransferase; A deep split separates two related families of proteins, one of which includes experimentally characterized examples of nicotinate phosphoribosyltransferase, an the first enzyme of NAD salvage biosynthesis. This model represents the other family. Members have a different (longer) spacing of several key motifs and have an additional C-terminal domain of up to 100 residues. One argument suggesting that this family represents the same enzyme is that no species has a member of both families. Another is that the gene encoding this protein is located near other NAD salvage biosynthesis genes in Nostoc and in at least four different Gram-positive bacteria. NAD and NADP are ubiquitous in life. Most members of this family are Gram-positive bacteria. An additional set of mutually closely related archaeal sequences score between the trusted and noise cutoffs. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pyridine nucleotides]
Pssm-ID: 273666 [Multi-domain] Cd Length: 443 Bit Score: 132.87 E-value: 1.41e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500920205 15 LDTDFYKLTMMQAVL-HNYPNAEVEWEFRCRSSEDLTPYL--AEIRYQIERLSELSITADQLAFLERIPFIKPDFIRFLS 91
Cdd:TIGR01513 2 LLTDLYELTMAQGYFrEGKANQPAVFEVFFRKLPFGRGYAvfAGLEDLLEFLENFRFDAEDIEYLASLGIFDDAFLDYLR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500920205 92 LFRFNLRyVHtGIEDGQLS------IRLRGPWLHVILFEVPLLAIVSevrnryryREVLLEQAAERLYQkldwlraeASE 165
Cdd:TIGR01513 82 EFRFSGT-VR-ALPEGSLVfpneplLQVEGPLIEAQLLETLVLNIIN--------FQTLIATKAARIVL--------AAG 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500920205 166 DElagfQLADFGTRRRFSYrvqEQAVHILKRDFPGRFVGTSNVHLAREFDLKPIGTMAHEWLMAHqqlgprliDSQIAAL 245
Cdd:TIGR01513 144 GK----PLLEFGLRRAQGP---DAALKAARAAYIGGADGTSNVLAGRLYGIPVSGTMAHSFVMSF--------DNELAAF 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500920205 246 DCWVREY--RGQLGIALTDCIT--MDAFLADFD-LYFAKLFDGLRHDSGDPLEWAEKAIAHYEKLGidpLSKTLVF-SDG 319
Cdd:TIGR01513 209 RAYAKLYpkATVLLVDTYDTLRsgLPNAIAVAKeLGEQGKVVGVRIDSGDLLYLSKQARKQLDAAG---LTQVKIVvSND 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500920205 320 LDLPKSLRLyRALSGRIHVsFGVGTNL-TCdiPGVEPMNIVIKMIACNGQPVAKISDTPGKTQcrdenfVSYLKHVFRVT 398
Cdd:TIGR01513 286 LDENSIAAL-KAEGAPIDV-YGVGTSLvTA--SDAPALGGVYKLVAYEGRPVMKLSENPEKST------LPGRKQVFRLY 355
|
.
gi 500920205 399 Q 399
Cdd:TIGR01513 356 D 356
|
|
| NAPRTase_A |
cd01570 |
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate ... |
15-348 |
2.07e-23 |
|
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products. This subgroup is present in bacteria and eukaryota (except funghi).
Pssm-ID: 238804 [Multi-domain] Cd Length: 327 Bit Score: 99.57 E-value: 2.07e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500920205 15 LDTDFYKLTMMQAVLH-NYPNAEVEWEFRCRSSEDLTPYL--AEIRYQIERLSELSITADQLAFLERIPFIKPDFIRFLS 91
Cdd:cd01570 2 LLTDLYQLTMAQAYWKeGKHNKPAVFELFFRKLPFGGGYAvfAGLEELLEYLENFRFTEEDIDYLRSLGIFDEEFLDYLR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500920205 92 LFRFNLRyVHtGIEDGQLS------IRLRGPWLHVILFEVPLLAIVSevrnryryREVLLEQAAERLyqkldWLRAEase 165
Cdd:cd01570 82 GFRFTGT-IY-AIPEGEVVfpneplLTVEGPLIEAQLLETLLLNLIN--------FQTLIATKAARV-----RLAAG--- 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500920205 166 delaGFQLADFGTRRRFSYrvqEQAVHILKRDFPGRFVGTSNVHLAREFDLKPIGTMAHEWLMAHqqlgprliDSQIAAL 245
Cdd:cd01570 144 ----GRPLLEFGLRRAQGP---DAALSAARAAYIGGFDGTSNVLAGKLYGIPVSGTMAHSFVQAF--------DDELAAF 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500920205 246 DCWVREYRGQLgIALTDciTMD-----------AFLADFDLYFaKLFdGLRHDSGDPLEWAEKAIAHYEKLGidpLSKTL 314
Cdd:cd01570 209 RAFAEAYPDNF-TLLVD--TYDtlrsglpnaiaVAKELGALGY-RLV-GVRIDSGDLAYLSKEARKMLDEAG---LTKVK 280
|
330 340 350
....*....|....*....|....*....|....*.
gi 500920205 315 VF-SDGLDlPKSLRLYRALSGRIHVsFGVGTNL-TC 348
Cdd:cd01570 281 IVaSNDLD-EYTIAALNAQGAPIDA-FGVGTRLvTS 314
|
|
| PRK09243 |
PRK09243 |
nicotinate phosphoribosyltransferase; Validated |
15-380 |
4.53e-19 |
|
nicotinate phosphoribosyltransferase; Validated
Pssm-ID: 236426 [Multi-domain] Cd Length: 464 Bit Score: 88.67 E-value: 4.53e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500920205 15 LDTDFYKLTMMQAVLHNYP-NAEVEWEFRCRSSEDLTPY-----LAEIryqIERLSELSITADQLAFLERIPFIKPDFIR 88
Cdd:PRK09243 11 LLTDLYELTMAQAYLRDGIhNRRAVFELFFRKLPFGRGYavfagLERL---LEYLENLRFTEEDIEYLRSLGIFDEDFLD 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500920205 89 FLSLFRFNLRyVHtGIEDGQLS------IRLRGPWLHVILFEVPLLAIVsevrNryrYrEVLLEQAAERLYQkldwlrae 162
Cdd:PRK09243 88 YLRNFRFTGD-VR-AVPEGELVfpneplLRVEGPLAEAQLLETLLLNII----N---F-QTLIATKAARIVS-------- 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500920205 163 ASEDELagfqLADFGTRRRFSY-------RvqeqAVHIlkrdfpGRFVGTSNVHLAREFDLKPIGTMAHEWLMAHqqlgp 235
Cdd:PRK09243 150 AAGGRP----LLEFGSRRAQGPdaavwaaR----AAYI------GGFDATSNVLAGKRYGIPVSGTMAHSFVQAF----- 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500920205 236 rliDSQIAALDCWVREYRgqlgialTDCItmdaFLAD-FD---------------LYFAKLFDGLRHDSGDPLEWAEKAI 299
Cdd:PRK09243 211 ---DDEYEAFRAYAETYP-------DNTV----LLVDtYDtlksgvpnaikvakeLGDGIELGGVRIDSGDLAYLSKKVR 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500920205 300 AHYEKLGidpLSKTLVF-SDGLD--LPKSLRLYRAlsgRIHVsFGVGTNL-TCDipGVEPMNIVIKMIACNG----QPVA 371
Cdd:PRK09243 277 KMLDEAG---FTDTKIVaSNDLDeyTIASLKLQGA---PIDG-FGVGTKLvTGS--DAPALGGVYKLVAIEGeggmIPKI 347
|
....*....
gi 500920205 372 KISDTPGKT 380
Cdd:PRK09243 348 KLSNSPEKV 356
|
|
| PRK12484 |
PRK12484 |
nicotinate phosphoribosyltransferase; Provisional |
15-379 |
3.41e-17 |
|
nicotinate phosphoribosyltransferase; Provisional
Pssm-ID: 237112 [Multi-domain] Cd Length: 443 Bit Score: 82.87 E-value: 3.41e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500920205 15 LDTDFYKLTMMQAVLHNYPNAEVEWEFRCRSSEDLTPYL--AEIRYQIERLSELSITADQLAFLERIPFIKPDFIRFLSL 92
Cdd:PRK12484 6 LLTDLYEVTMANAYLREGMSAPATFSLFYRKLPDGRGFLiaAGLADVVEFLEAFRFDEQDLRYLRGLNQFSEEFLAWLAG 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500920205 93 FRF--NLRYVHTG--IEDGQLSIRLRGPWLHVILFEVPLLAIVSevrnryryREVLLEQAAERLyqkldwlRAEAsedel 168
Cdd:PRK12484 86 LRFtgDVRAVPEGtvVFPNEPLLEVTAPLIEAQLVETFLLNQIN--------HQSLIASKAARC-------VLAA----- 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500920205 169 AGFQLADFGTRRRFSYrvqEQAVHILKRDFPGRFVGTSNVHLAREFDLKPIGTMAHEWLMAhqqlgprlIDSQIAALDCW 248
Cdd:PRK12484 146 AGRPVVDFGARRAHGT---DAACYVARASYLAGAAGTSNVLAARQYGIPASGTMAHSFVEA--------FPDEVAAFRAF 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500920205 249 VREYRGQLgIALTDciTMDA---------FLADFDLYFAKLfdGLRHDSGDPLEWAEKAIAHYEKLGIDPLSktLVFSDG 319
Cdd:PRK12484 215 ARLYPDAT-TLLVD--TYDTlrgvrnaieVAKELGNRFDPR--GVRLDSGDLAELSKATRAILDAAGLEQVK--IVASGG 287
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 500920205 320 LDLPKSLRLYRAlSGRIHVsFGVGTNL--TCDIPGvepMNIVIKMIACNGQPVAKISdtPGK 379
Cdd:PRK12484 288 LDEYRIAALLAA-GAPIDG-FGVGTRLgvAADAPV---LDSAYKLVAYEGRGVTKLS--SGK 342
|
|
| |
