|
Name |
Accession |
Description |
Interval |
E-value |
| PRK06078 |
PRK06078 |
pyrimidine-nucleoside phosphorylase; Reviewed |
1-425 |
0e+00 |
|
pyrimidine-nucleoside phosphorylase; Reviewed
Pssm-ID: 180387 [Multi-domain] Cd Length: 434 Bit Score: 788.51 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500941435 1 MRAVDLIQKKRDGLELSSEEIKWLIDGYVAGTVPDYQMSALAMAIYFKGMSTREISDLTMSMVATGEQIDLSAIPGIKVD 80
Cdd:PRK06078 1 MRMVDLIQKKRDGKELTTEEINFFIEGYTNGTIPDYQMSALAMAIYFKDMTDRERADLTMAMVNSGDTIDLSAIEGIKVD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500941435 81 KHSTGGVGDKVTLILAPLVASFDIPVAKMSGRGLGHTGGTLDKLESIKGYQIEVSQADFIKQVQDTGVAVIGQSDNLVKA 160
Cdd:PRK06078 81 KHSTGGVGDTTTLVLAPLVAAFGVPVAKMSGRGLGHTGGTIDKLESIKGFHVEISQEDFIKLVNENKVAVIGQSGNLTPA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500941435 161 DKLLYALRDVTATVDIIPLIASSVMSKKIAAGADAILLDVTVGEGAFMKTVEEARVLAQTMVDLGKAVGRKTVAVLTDMS 240
Cdd:PRK06078 161 DKKLYALRDVTATVNSIPLIASSIMSKKIAAGADAIVLDVKTGAGAFMKTVEDAEELAHAMVRIGNNVGRNTMAVISDMS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500941435 241 QPVGTSIGNRLEILEAIEILQGKGREDVTEFICELAQIMLGLANVEKSIEEVRQH----IDNGAALKKFEEMVRAQGGD- 315
Cdd:PRK06078 241 QPLGRAIGNALEVLEAIDTLQGKGPKDLTELVLTLGSQMVVLAGKAKTLEEAREHlievMNNGKALEKFKEFLSAQGGDa 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500941435 316 --LEDLYRPVQVTQQVPVLAEEDGYIVGLPALEFGLFAMKLGAGRAVKTDNLDYETGIVFHKKVGEAVSKGEQIATIYAN 393
Cdd:PRK06078 321 svVDDPEKLPQAKYQIEVPAKESGYISELVADEIGLAAMLLGAGRATKEDEIDLAVGIVLRKKVGDSVKKGESLATIYAN 400
|
410 420 430
....*....|....*....|....*....|..
gi 500941435 394 ENISENMLTNFQKNVKIDKESVKTKEIIEIIS 425
Cdd:PRK06078 401 RENVEDVKAKFYKNIKISKEHVVAPELIHIII 432
|
|
| DeoA |
COG0213 |
Thymidine phosphorylase [Nucleotide transport and metabolism]; Thymidine phosphorylase is part ... |
3-424 |
0e+00 |
|
Thymidine phosphorylase [Nucleotide transport and metabolism]; Thymidine phosphorylase is part of the Pathway/BioSystem: Pyrimidine salvage
Pssm-ID: 439983 [Multi-domain] Cd Length: 431 Bit Score: 652.87 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500941435 3 AVDLIQKKRDGLELSSEEIKWLIDGYVAGTVPDYQMSALAMAIYFKGMSTREISDLTMSMVATGEQIDLSAIPGIKVDKH 82
Cdd:COG0213 1 AVDIIRKKRDGGELTAEEIRFFIDGYTDGSIPDYQMAAFLMAVYFRGMTDEETAALTLAMRDSGDVLDLSDIPGPKVDKH 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500941435 83 STGGVGDKVTLILAPLVASFDIPVAKMSGRGLGHTGGTLDKLESIKGYQIEVSQADFIKQVQDTGVAVIGQSDNLVKADK 162
Cdd:COG0213 81 STGGVGDKTSLVLAPLVAACGVPVPKMSGRGLGHTGGTLDKLESIPGFRTELSEEEFRRQVNEIGCAIIGQTGDLAPADK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500941435 163 LLYALRDVTATVDIIPLIASSVMSKKIAAGADAILLDVTVGEGAFMKTVEEARVLAQTMVDLGKAVGRKTVAVLTDMSQP 242
Cdd:COG0213 161 KLYALRDVTATVESIPLIASSIMSKKLAAGADALVLDVKVGSGAFMKTLEDARELAESMVDIGNGAGRKTVALITDMNQP 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500941435 243 VGTSIGNRLEILEAIEILQGKGREDVTEFICELAQIMLGLANVEKSIEE----VRQHIDNGAALKKFEEMVRAQGGD--- 315
Cdd:COG0213 241 LGRAVGNALEVKEAIETLKGEGPEDLTELTLALGAEMLVLAGLAKDLEEarakLEEALASGKALEKFKEMVAAQGGDpdv 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500941435 316 LEDLYRPVQVTQQVPVLAEEDGYIVGLPALEFGLFAMKLGAGRAVKTDNLDYETGIVFHKKVGEAVSKGEQIATIYANEN 395
Cdd:COG0213 321 VDDPELLPQAPVVREVKAPRSGYVSAIDARAIGLAAVLLGAGRATKEDPIDPAVGIVLLKKVGDKVEKGEPLATIHANDE 400
|
410 420 430
....*....|....*....|....*....|.
gi 500941435 396 IS-ENMLTNFQKNVKIDKESVKTKEII-EII 424
Cdd:COG0213 401 ADaEEAAERLRAAYTIGDEPPEPPPLIyERI 431
|
|
| Y_phosphoryl |
TIGR02644 |
pyrimidine-nucleoside phosphorylase; In general, members of this protein family are designated ... |
3-397 |
0e+00 |
|
pyrimidine-nucleoside phosphorylase; In general, members of this protein family are designated pyrimidine-nucleoside phosphorylase, enzyme family EC 2.4.2.2, as in Bacillus subtilis, and more narrowly as the enzyme family EC 2.4.2.4, thymidine phosphorylase (alternate name: pyrimidine phosphorylase), as in Escherichia coli. The set of proteins encompassed by this model is designated subfamily rather than equivalog for this reason; the protein name from this model should be used when TIGR02643 does not score above trusted cutoff. [Purines, pyrimidines, nucleosides, and nucleotides, Other]
Pssm-ID: 274244 [Multi-domain] Cd Length: 405 Bit Score: 586.12 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500941435 3 AVDLIQKKRDGLELSSEEIKWLIDGYVAGTVPDYQMSALAMAIYFKGMSTREISDLTMSMVATGEQIDLSAIPGIKVDKH 82
Cdd:TIGR02644 1 AVDIIRKKRDGKKLSDEEINFFINGYTNGEIPDYQMSALLMAIYFNGMTDEETAYLTKAMIDSGEVLDLSSLPGPKVDKH 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500941435 83 STGGVGDKVTLILAPLVASFDIPVAKMSGRGLGHTGGTLDKLESIKGYQIEVSQADFIKQVQDTGVAVIGQSDNLVKADK 162
Cdd:TIGR02644 81 STGGVGDKVSLVLGPIVAACGVKVAKMSGRGLGHTGGTIDKLESIPGFRTELSEAEFIEIVNKVGLAIIGQTKDLAPADK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500941435 163 LLYALRDVTATVDIIPLIASSVMSKKIAAGADAILLDVTVGEGAFMKTVEEARVLAQTMVDLGKAVGRKTVAVLTDMSQP 242
Cdd:TIGR02644 161 KLYALRDVTGTVDSIPLIASSIMSKKLAAGADAIVLDVKVGSGAFMKTLEDAKELAKLMVEIGKGAGRKTSALLTDMNQP 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500941435 243 VGTSIGNRLEILEAIEILQGKGREDVTEFICELAQIMLGLANVEKSIEEVRQH----IDNGAALKKFEEMVRAQGGD--- 315
Cdd:TIGR02644 241 LGRAIGNALEVKEAVEFLKGEGPADLKELTLALAAEMLLLAGIAKTEKEARALaedvLESGKALEKFRRFVEAQGGDpdv 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500941435 316 LEDLYRPVQVTQQVPVLAEEDGYIVGLPALEFGLFAMKLGAGRAVKTDNLDYETGIVFHKKVGEAVSKGEQIATIYANEN 395
Cdd:TIGR02644 321 IKNLDKLPKAKYKEEVKAEKSGYISEIDAEELGLAAVDLGAGRARKEDKIDHEAGIYLHKKTGDRVKKGDPLATLYSSDP 400
|
..
gi 500941435 396 IS 397
Cdd:TIGR02644 401 IS 402
|
|
| Glycos_transf_3 |
pfam00591 |
Glycosyl transferase family, a/b domain; This family includes anthranilate ... |
76-302 |
1.21e-43 |
|
Glycosyl transferase family, a/b domain; This family includes anthranilate phosphoribosyltransferase (TrpD), thymidine phosphorylase. All these proteins can transfer a phosphorylated ribose substrate.
Pssm-ID: 459860 [Multi-domain] Cd Length: 253 Bit Score: 153.21 E-value: 1.21e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500941435 76 GIKVDKHSTGGVGDK---VTLILAPLVASFDIPVAKMSGRGLGHTGGTLDKLESIkGYQIEVSQADFIKQVQDTGVAVIG 152
Cdd:pfam00591 2 GDLVDIVGTGGDGDNtfnISTAAAIVAAACGVKVAKHGNRSVSSKSGSADVLEAL-GINLDLTPEQVRKLLDEVGVGFLF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500941435 153 QSDNLVKADKLLYALRDVTA-TVDII--PLIAS--------SVMSKKIAAGADAILLDVTVGEGAFMKTV--EEARVLAQ 219
Cdd:pfam00591 81 APNYHPAMKHVAPVRRELGIrTVFNLlgPLINParvkrqvlGVYSKELAEGLAEVLKDLGRERAAVVHGDglDEASLLGK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500941435 220 TMVDLGKAvGRKTVAVLTDMSQPVGTSIGNRLEILEAIE-------ILQGKGREDVTEFICELAQIMLGLANVEKSIEE- 291
Cdd:pfam00591 161 TTVAELKD-GEITEYTLTPEDFGLGRATLEALEGGSPKEnadilkgVLGGKGSAAHRDLVALNAGAALYLAGKADSLKEg 239
|
250
....*....|....
gi 500941435 292 ---VRQHIDNGAAL 302
Cdd:pfam00591 240 vakALEVIDSGKAL 253
|
|
| PYNP_C |
smart00941 |
Pyrimidine nucleoside phosphorylase C-terminal domain; This domain is found at the C-terminal ... |
338-411 |
4.49e-20 |
|
Pyrimidine nucleoside phosphorylase C-terminal domain; This domain is found at the C-terminal end of the large alpha/beta domain making up various pyrimidine nucleoside phosphorylases. It has slightly different conformations in different members of this family. For example, in pyrimidine nucleoside phosphorylase (PYNP) there is an added three-stranded anti-parallel beta sheet as compared to other members of the family, such as E. coli thymidine phosphorylase (TP). The domain contains an alpha/ beta hammerhead fold and residues in this domain seem to be important in formation of the homodimer.
Pssm-ID: 214925 [Multi-domain] Cd Length: 75 Bit Score: 83.74 E-value: 4.49e-20
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 500941435 338 YIVGLPALEFGLFAMKLGAGRAVKTDNLDYETGIVFHKKVGEAVSKGEQIATIYANENISENMLTNF-QKNVKID 411
Cdd:smart00941 1 YVTAIDARALGLAAVLLGAGRARKEDPIDYGVGIVLHKKLGDRVKKGEPLATIHANDEAELEEAAEAlRAAITIS 75
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK06078 |
PRK06078 |
pyrimidine-nucleoside phosphorylase; Reviewed |
1-425 |
0e+00 |
|
pyrimidine-nucleoside phosphorylase; Reviewed
Pssm-ID: 180387 [Multi-domain] Cd Length: 434 Bit Score: 788.51 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500941435 1 MRAVDLIQKKRDGLELSSEEIKWLIDGYVAGTVPDYQMSALAMAIYFKGMSTREISDLTMSMVATGEQIDLSAIPGIKVD 80
Cdd:PRK06078 1 MRMVDLIQKKRDGKELTTEEINFFIEGYTNGTIPDYQMSALAMAIYFKDMTDRERADLTMAMVNSGDTIDLSAIEGIKVD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500941435 81 KHSTGGVGDKVTLILAPLVASFDIPVAKMSGRGLGHTGGTLDKLESIKGYQIEVSQADFIKQVQDTGVAVIGQSDNLVKA 160
Cdd:PRK06078 81 KHSTGGVGDTTTLVLAPLVAAFGVPVAKMSGRGLGHTGGTIDKLESIKGFHVEISQEDFIKLVNENKVAVIGQSGNLTPA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500941435 161 DKLLYALRDVTATVDIIPLIASSVMSKKIAAGADAILLDVTVGEGAFMKTVEEARVLAQTMVDLGKAVGRKTVAVLTDMS 240
Cdd:PRK06078 161 DKKLYALRDVTATVNSIPLIASSIMSKKIAAGADAIVLDVKTGAGAFMKTVEDAEELAHAMVRIGNNVGRNTMAVISDMS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500941435 241 QPVGTSIGNRLEILEAIEILQGKGREDVTEFICELAQIMLGLANVEKSIEEVRQH----IDNGAALKKFEEMVRAQGGD- 315
Cdd:PRK06078 241 QPLGRAIGNALEVLEAIDTLQGKGPKDLTELVLTLGSQMVVLAGKAKTLEEAREHlievMNNGKALEKFKEFLSAQGGDa 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500941435 316 --LEDLYRPVQVTQQVPVLAEEDGYIVGLPALEFGLFAMKLGAGRAVKTDNLDYETGIVFHKKVGEAVSKGEQIATIYAN 393
Cdd:PRK06078 321 svVDDPEKLPQAKYQIEVPAKESGYISELVADEIGLAAMLLGAGRATKEDEIDLAVGIVLRKKVGDSVKKGESLATIYAN 400
|
410 420 430
....*....|....*....|....*....|..
gi 500941435 394 ENISENMLTNFQKNVKIDKESVKTKEIIEIIS 425
Cdd:PRK06078 401 RENVEDVKAKFYKNIKISKEHVVAPELIHIII 432
|
|
| DeoA |
COG0213 |
Thymidine phosphorylase [Nucleotide transport and metabolism]; Thymidine phosphorylase is part ... |
3-424 |
0e+00 |
|
Thymidine phosphorylase [Nucleotide transport and metabolism]; Thymidine phosphorylase is part of the Pathway/BioSystem: Pyrimidine salvage
Pssm-ID: 439983 [Multi-domain] Cd Length: 431 Bit Score: 652.87 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500941435 3 AVDLIQKKRDGLELSSEEIKWLIDGYVAGTVPDYQMSALAMAIYFKGMSTREISDLTMSMVATGEQIDLSAIPGIKVDKH 82
Cdd:COG0213 1 AVDIIRKKRDGGELTAEEIRFFIDGYTDGSIPDYQMAAFLMAVYFRGMTDEETAALTLAMRDSGDVLDLSDIPGPKVDKH 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500941435 83 STGGVGDKVTLILAPLVASFDIPVAKMSGRGLGHTGGTLDKLESIKGYQIEVSQADFIKQVQDTGVAVIGQSDNLVKADK 162
Cdd:COG0213 81 STGGVGDKTSLVLAPLVAACGVPVPKMSGRGLGHTGGTLDKLESIPGFRTELSEEEFRRQVNEIGCAIIGQTGDLAPADK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500941435 163 LLYALRDVTATVDIIPLIASSVMSKKIAAGADAILLDVTVGEGAFMKTVEEARVLAQTMVDLGKAVGRKTVAVLTDMSQP 242
Cdd:COG0213 161 KLYALRDVTATVESIPLIASSIMSKKLAAGADALVLDVKVGSGAFMKTLEDARELAESMVDIGNGAGRKTVALITDMNQP 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500941435 243 VGTSIGNRLEILEAIEILQGKGREDVTEFICELAQIMLGLANVEKSIEE----VRQHIDNGAALKKFEEMVRAQGGD--- 315
Cdd:COG0213 241 LGRAVGNALEVKEAIETLKGEGPEDLTELTLALGAEMLVLAGLAKDLEEarakLEEALASGKALEKFKEMVAAQGGDpdv 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500941435 316 LEDLYRPVQVTQQVPVLAEEDGYIVGLPALEFGLFAMKLGAGRAVKTDNLDYETGIVFHKKVGEAVSKGEQIATIYANEN 395
Cdd:COG0213 321 VDDPELLPQAPVVREVKAPRSGYVSAIDARAIGLAAVLLGAGRATKEDPIDPAVGIVLLKKVGDKVEKGEPLATIHANDE 400
|
410 420 430
....*....|....*....|....*....|.
gi 500941435 396 IS-ENMLTNFQKNVKIDKESVKTKEII-EII 424
Cdd:COG0213 401 ADaEEAAERLRAAYTIGDEPPEPPPLIyERI 431
|
|
| Y_phosphoryl |
TIGR02644 |
pyrimidine-nucleoside phosphorylase; In general, members of this protein family are designated ... |
3-397 |
0e+00 |
|
pyrimidine-nucleoside phosphorylase; In general, members of this protein family are designated pyrimidine-nucleoside phosphorylase, enzyme family EC 2.4.2.2, as in Bacillus subtilis, and more narrowly as the enzyme family EC 2.4.2.4, thymidine phosphorylase (alternate name: pyrimidine phosphorylase), as in Escherichia coli. The set of proteins encompassed by this model is designated subfamily rather than equivalog for this reason; the protein name from this model should be used when TIGR02643 does not score above trusted cutoff. [Purines, pyrimidines, nucleosides, and nucleotides, Other]
Pssm-ID: 274244 [Multi-domain] Cd Length: 405 Bit Score: 586.12 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500941435 3 AVDLIQKKRDGLELSSEEIKWLIDGYVAGTVPDYQMSALAMAIYFKGMSTREISDLTMSMVATGEQIDLSAIPGIKVDKH 82
Cdd:TIGR02644 1 AVDIIRKKRDGKKLSDEEINFFINGYTNGEIPDYQMSALLMAIYFNGMTDEETAYLTKAMIDSGEVLDLSSLPGPKVDKH 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500941435 83 STGGVGDKVTLILAPLVASFDIPVAKMSGRGLGHTGGTLDKLESIKGYQIEVSQADFIKQVQDTGVAVIGQSDNLVKADK 162
Cdd:TIGR02644 81 STGGVGDKVSLVLGPIVAACGVKVAKMSGRGLGHTGGTIDKLESIPGFRTELSEAEFIEIVNKVGLAIIGQTKDLAPADK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500941435 163 LLYALRDVTATVDIIPLIASSVMSKKIAAGADAILLDVTVGEGAFMKTVEEARVLAQTMVDLGKAVGRKTVAVLTDMSQP 242
Cdd:TIGR02644 161 KLYALRDVTGTVDSIPLIASSIMSKKLAAGADAIVLDVKVGSGAFMKTLEDAKELAKLMVEIGKGAGRKTSALLTDMNQP 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500941435 243 VGTSIGNRLEILEAIEILQGKGREDVTEFICELAQIMLGLANVEKSIEEVRQH----IDNGAALKKFEEMVRAQGGD--- 315
Cdd:TIGR02644 241 LGRAIGNALEVKEAVEFLKGEGPADLKELTLALAAEMLLLAGIAKTEKEARALaedvLESGKALEKFRRFVEAQGGDpdv 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500941435 316 LEDLYRPVQVTQQVPVLAEEDGYIVGLPALEFGLFAMKLGAGRAVKTDNLDYETGIVFHKKVGEAVSKGEQIATIYANEN 395
Cdd:TIGR02644 321 IKNLDKLPKAKYKEEVKAEKSGYISEIDAEELGLAAVDLGAGRARKEDKIDHEAGIYLHKKTGDRVKKGDPLATLYSSDP 400
|
..
gi 500941435 396 IS 397
Cdd:TIGR02644 401 IS 402
|
|
| deoA |
PRK05820 |
thymidine phosphorylase; Reviewed |
1-425 |
0e+00 |
|
thymidine phosphorylase; Reviewed
Pssm-ID: 180276 [Multi-domain] Cd Length: 440 Bit Score: 513.60 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500941435 1 MRAVDLIQKKRDGLELSSEEIKWLIDGYVAGTVPDYQMSALAMAIYFKGMSTREISDLTMSMVATGEQIDLSAI--PGIK 78
Cdd:PRK05820 2 FLAQEIIRKKRDGGALSDEEIDWFIDGYTDGTVSDGQIAALAMAIFFNGMTRPERVALTLAMRDSGEVLDWSSLnlNGPI 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500941435 79 VDKHSTGGVGDKVTLILAPLVASFDIPVAKMSGRGLGHTGGTLDKLESIKGYQIEVSQADFIKQVQDTGVAVIGQSDNLV 158
Cdd:PRK05820 82 VDKHSTGGVGDKISLMLAPMVAACGGYVPMISGRGLGHTGGTLDKLEAIPGYRAFPSNDRFREILKDVGVAIIGQTSDLA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500941435 159 KADKLLYALRDVTATVDIIPLIASSVMSKKIAAGADAILLDVTVGEGAFMKTVEEARVLAQTMVDLGKAVGRKTVAVLTD 238
Cdd:PRK05820 162 PADKRLYALRDVTATVESIPLITASILSKKLAEGLDALVLDVKVGSGAFMKTYEEARELARSMVEVANGAGVRTTALLTD 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500941435 239 MSQPVGTSIGNRLEILEAIEILQGKGR-EDVTEFICELAQIMLGLANVEKSIEE----VRQHIDNGAALKKFEEMVRAQG 313
Cdd:PRK05820 242 MNQPLASSAGNALEVREAVEFLTGGYRpPRLVEVTMALAAEMLVLAGLAKDEAEaradLAAVLDSGKAAERFGRMVAAQG 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500941435 314 GDLEDLYRPV----QVTQQVPVLAEEDGYIVGLPALEFGLFAMKLGAGRAVKTDNLDYETGIVFHKKVGEAVSKGEQIAT 389
Cdd:PRK05820 322 GPPDFVENYDkylpTAPHTKPVYADRSGVLSAMDTRALGMAVVRLGGGRRRKGDPIDYSVGLTLHARLGDRVDAGEPLAT 401
|
410 420 430
....*....|....*....|....*....|....*...
gi 500941435 390 IYANENIS-ENMLTNFQKNVKI-DKESVKTKEIIEIIS 425
Cdd:PRK05820 402 LHADDEERfQEAAAALKAAIRIgDEAPEATPLIYRRIT 439
|
|
| T_phosphoryl |
TIGR02643 |
thymidine phosphorylase; Thymidine phosphorylase (alternate name: pyrimidine phosphorylase), ... |
1-424 |
1.49e-119 |
|
thymidine phosphorylase; Thymidine phosphorylase (alternate name: pyrimidine phosphorylase), EC 2.4.2.4, is the designation for the enzyme of E. coli and other Proteobacteria involved in (deoxy)nucleotide degradation. It often occurs in an operon with a deoxyribose-phosphate aldolase, phosphopentomutase and a purine nucleoside phosphorylase. In many other lineages, the corresponding enzyme is designated pyrimidine-nucleoside phosphorylase (EC 2.4.2.2); the naming convention imposed by this model represents standard literature practice. [Purines, pyrimidines, nucleosides, and nucleotides, Other]
Pssm-ID: 131691 Cd Length: 437 Bit Score: 355.21 E-value: 1.49e-119
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500941435 1 MRAVDLIQKKRDGLELSSEEIKWLIDGYVAGTVPDYQMSALAMAIYFKGMSTREISDLTMSMVATGEQIDLSA--IPGIK 78
Cdd:TIGR02643 1 FLPQEIIRKKRDGHSLSDAEIAQFINGITDGSVSEGQIAAFAMAVFFNGMNRDERVALTLAMRDSGDVLDWRSldLNGPV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500941435 79 VDKHSTGGVGDKVTLILAPLVASFDIPVAKMSGRGLGHTGGTLDKLESIKGYQIEVSQADFIKQVQDTGVAVIGQSDNLV 158
Cdd:TIGR02643 81 VDKHSTGGVGDVVSLMLGPIVAACGGYVPMISGRGLGHTGGTLDKLEAIPGYDIFPDPALFRRVVKDVGVAIIGQTADLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500941435 159 KADKLLYALRDVTATVDIIPLIASSVMSKKIAAGADAILLDVTVGEGAFMKTVEEARVLAQTMVDLGKAVGRKTVAVLTD 238
Cdd:TIGR02643 161 PADKRFYATRDVTATVESIPLITASILSKKLAAGLDALVMDVKVGNGAFMPTYEESEELARSLVDVANGAGVRTTALITD 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500941435 239 MSQPVGTSIGNRLEILEAIEILQGKGR----EDVTEFICELAQIMLGLANVEKSIE-EVRQHIDNGAALKKFEEMVRAQG 313
Cdd:TIGR02643 241 MNQPLASAAGNAVEVRNAVDFLTGEKRnprlEDVTMALAAEMLVSGGLAADEAEARaKLQAVLDSGRAAERFARMVAALG 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500941435 314 GDLEDLYRPVQVTQQV----PVLAEEDGYIVGLPALEFGLFAMKLGAGRAVKTDNLDYETGIVFHKKVGEAVSKGEQIAT 389
Cdd:TIGR02643 321 GPADFVENPERYLATAplikPVYADREGYVSEMDTRALGMAVVALGGGRRKADDTIDYSVGLTDLLPLGDRVEKGEPLAV 400
|
410 420 430
....*....|....*....|....*....|....*..
gi 500941435 390 IYA-NENISENMLTNFQKNVKI-DKESVKTKEIIEII 424
Cdd:TIGR02643 401 VHAaDESDAEEAAKRVKAAYRIaDEAPESTPVVYRRI 437
|
|
| PRK04350 |
PRK04350 |
thymidine phosphorylase; Provisional |
4-392 |
3.72e-65 |
|
thymidine phosphorylase; Provisional
Pssm-ID: 235289 [Multi-domain] Cd Length: 490 Bit Score: 216.21 E-value: 3.72e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500941435 4 VDLIQKKRDGLELSSEEIKWLIDGYVAGTVPDYQMSALAMAIYFKGMSTREISDLTMSMVATGEQIDLSAipGIKVDKHS 83
Cdd:PRK04350 82 LSAIRKKIDGEKLDKEEIEAIIRDIVAGRYSDIELSAFLTASAINGLDMDEIEALTRAMVETGERLDWDR--PPVVDKHS 159
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500941435 84 TGGV-GDKVTLILAPLVASFDIPVAKMSGRGLGHTGGTLDKLESIKgyQIEVSqADFIKQVQDT--GVAVIGQSDNLVKA 160
Cdd:PRK04350 160 IGGVpGNRTTLIVVPIVAAAGLTIPKTSSRAITSPAGTADTMEVLA--PVDLS-VEEIKRVVEKvgGCLVWGGAVNLSPA 236
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500941435 161 DKLL----YALRdvtatVDIIPLIASSVMSKKIAAGADAILLDVTVGEGAFMKTVEEARVLAQTMVDLGKAVGRKTVAVL 236
Cdd:PRK04350 237 DDILirveRPLS-----IDPRGQLVASILSKKIAAGSTHVVIDIPVGPTAKVRSVEEARRLARLFEEVGDRLGLRVECAI 311
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500941435 237 TDMSQPVGTSIGNRLEILEAIEILQGKGR--EDVTEFICELAQIML---GLANVEKSIEEVRQHIDNGAALKKFEEMVRA 311
Cdd:PRK04350 312 TDGSQPIGRGIGPALEARDVLAVLENDPDapNDLREKSLRLAGILLemgGVAPGGEGYALAREILESGKALEKFQEIIEA 391
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500941435 312 QGGDLEDlyrPVQVTQQVPVLAEEDGYIVGLPALEFGLFAMKLGAGRavktdnlDYETGIVFHKKVGEAVSKGEQIATIY 391
Cdd:PRK04350 392 QGGDSED---IPLGDHTHDVTAPRDGYVTAIDNRRLARIARLAGAPK-------DKGAGIDLHVKVGDKVKKGDPLYTIH 461
|
.
gi 500941435 392 A 392
Cdd:PRK04350 462 A 462
|
|
| Glycos_transf_3 |
pfam00591 |
Glycosyl transferase family, a/b domain; This family includes anthranilate ... |
76-302 |
1.21e-43 |
|
Glycosyl transferase family, a/b domain; This family includes anthranilate phosphoribosyltransferase (TrpD), thymidine phosphorylase. All these proteins can transfer a phosphorylated ribose substrate.
Pssm-ID: 459860 [Multi-domain] Cd Length: 253 Bit Score: 153.21 E-value: 1.21e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500941435 76 GIKVDKHSTGGVGDK---VTLILAPLVASFDIPVAKMSGRGLGHTGGTLDKLESIkGYQIEVSQADFIKQVQDTGVAVIG 152
Cdd:pfam00591 2 GDLVDIVGTGGDGDNtfnISTAAAIVAAACGVKVAKHGNRSVSSKSGSADVLEAL-GINLDLTPEQVRKLLDEVGVGFLF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500941435 153 QSDNLVKADKLLYALRDVTA-TVDII--PLIAS--------SVMSKKIAAGADAILLDVTVGEGAFMKTV--EEARVLAQ 219
Cdd:pfam00591 81 APNYHPAMKHVAPVRRELGIrTVFNLlgPLINParvkrqvlGVYSKELAEGLAEVLKDLGRERAAVVHGDglDEASLLGK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500941435 220 TMVDLGKAvGRKTVAVLTDMSQPVGTSIGNRLEILEAIE-------ILQGKGREDVTEFICELAQIMLGLANVEKSIEE- 291
Cdd:pfam00591 161 TTVAELKD-GEITEYTLTPEDFGLGRATLEALEGGSPKEnadilkgVLGGKGSAAHRDLVALNAGAALYLAGKADSLKEg 239
|
250
....*....|....
gi 500941435 292 ---VRQHIDNGAAL 302
Cdd:pfam00591 240 vakALEVIDSGKAL 253
|
|
| Glycos_trans_3N |
pfam02885 |
Glycosyl transferase family, helical bundle domain; This family includes anthranilate ... |
4-66 |
1.50e-21 |
|
Glycosyl transferase family, helical bundle domain; This family includes anthranilate phosphoribosyltransferase (TrpD), thymidine phosphorylase. All these proteins can transfer a phosphorylated ribose substrate.
Pssm-ID: 460737 [Multi-domain] Cd Length: 63 Bit Score: 87.43 E-value: 1.50e-21
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 500941435 4 VDLIQKKRDGLELSSEEIKWLIDGYVAGTVPDYQMSALAMAIYFKGMSTREISDLTMSMVATG 66
Cdd:pfam02885 1 KELIKKLRDGEDLTREEARAAMDGIMSGEATDAQIAAFLMALRMKGETAEEIAGLARAMRESG 63
|
|
| PYNP_C |
pfam07831 |
Pyrimidine nucleoside phosphorylase C-terminal domain; This domain is found at the C-terminal ... |
338-410 |
2.80e-20 |
|
Pyrimidine nucleoside phosphorylase C-terminal domain; This domain is found at the C-terminal end of the large alpha/beta domain making up various pyrimidine nucleoside phosphorylases. It has slightly different conformations in different members of this family. For example, in pyrimidine nucleoside phosphorylase (PYNP) there is an added three-stranded anti-parallel beta sheet as compared to other members of the family, such as E. coli thymidine phosphorylase (TP). The domain contains an alpha/ beta hammerhead fold and residues in this domain seem to be important in formation of the homodimer.
Pssm-ID: 429685 [Multi-domain] Cd Length: 74 Bit Score: 84.16 E-value: 2.80e-20
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 500941435 338 YIVGLPALEFGLFAMKLGAGRAVKTDNLDYETGIVFHKKVGEAVSKGEQIATIYAN-ENISENMLTNFQKNVKI 410
Cdd:pfam07831 1 YVSSIDAREIGMAAMELGAGRATKTDPIDYGVGIYLHKKLGDKVKKGEPLATIYANdEIRLEEAVKKLKKAIEI 74
|
|
| PYNP_C |
smart00941 |
Pyrimidine nucleoside phosphorylase C-terminal domain; This domain is found at the C-terminal ... |
338-411 |
4.49e-20 |
|
Pyrimidine nucleoside phosphorylase C-terminal domain; This domain is found at the C-terminal end of the large alpha/beta domain making up various pyrimidine nucleoside phosphorylases. It has slightly different conformations in different members of this family. For example, in pyrimidine nucleoside phosphorylase (PYNP) there is an added three-stranded anti-parallel beta sheet as compared to other members of the family, such as E. coli thymidine phosphorylase (TP). The domain contains an alpha/ beta hammerhead fold and residues in this domain seem to be important in formation of the homodimer.
Pssm-ID: 214925 [Multi-domain] Cd Length: 75 Bit Score: 83.74 E-value: 4.49e-20
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 500941435 338 YIVGLPALEFGLFAMKLGAGRAVKTDNLDYETGIVFHKKVGEAVSKGEQIATIYANENISENMLTNF-QKNVKID 411
Cdd:smart00941 1 YVTAIDARALGLAAVLLGAGRARKEDPIDYGVGIVLHKKLGDRVKKGEPLATIHANDEAELEEAAEAlRAAITIS 75
|
|
| PRK14607 |
PRK14607 |
bifunctional anthranilate synthase component II/anthranilate phosphoribosyltransferase; |
4-314 |
2.98e-08 |
|
bifunctional anthranilate synthase component II/anthranilate phosphoribosyltransferase;
Pssm-ID: 237764 [Multi-domain] Cd Length: 534 Bit Score: 55.49 E-value: 2.98e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500941435 4 VDLIQKKRDGLELSSEEIKWLIDGYVAGTVPDYQMSALAMAIYFKGMSTREISdlTMSMVATGEQIDLSAIPGIKVDKHS 83
Cdd:PRK14607 196 KSYLKKLVEGEDLSFEEAEDVMEDITDGNATDAQIAGFLTALRMKGETADELA--GFASVMREKSRHIPAPSPRTVDTCG 273
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500941435 84 TGGVGDK---VTLILAPLVASFDIPVAKMSGRGLGHTGGTLDKLESIkGYQIEVSQADFIKQVQDTGVAvigqsdnLVKA 160
Cdd:PRK14607 274 TGGDGFGtfnISTTSAFVVAAAGVPVAKHGNRAVSSKSGSADVLEAL-GVKLEMTPEEAASVLRETGFS-------FLFA 345
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500941435 161 DKLLYALRDVTA------TVDIIPLIASsvmskkIAAGADAILLDVTVGEGAFmktveeARVLAQTMVDLGkaVGRKTVA 234
Cdd:PRK14607 346 PLFHPAMKHAAParrelgIRTAFNLLGP------LTNPARVKYQIVGVFDPSY------AEPLAQALQRLG--TERAMVV 411
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500941435 235 VLTDMSQPVGTSIGNRLEILE-----------------------------------AIEILQGKGREDVTEFICELAQIM 279
Cdd:PRK14607 412 SGIDGYDEISTCGPTQILELEdgeivtytfdpeelglkrvdpeelkggdpqenyrlAEDVLKGEPRRPQRDAVALNAGAA 491
|
330 340 350
....*....|....*....|....*....|....*....
gi 500941435 280 LGLANVEKSIEE----VRQHIDNGAALKKFEEMVRAQGG 314
Cdd:PRK14607 492 LYLVGEADSIKEgvgkALDLIDDGRAYKKLEEVMDLSKT 530
|
|
| trpD |
PRK00188 |
anthranilate phosphoribosyltransferase; Provisional |
5-311 |
2.53e-07 |
|
anthranilate phosphoribosyltransferase; Provisional
Pssm-ID: 234682 [Multi-domain] Cd Length: 339 Bit Score: 52.00 E-value: 2.53e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500941435 5 DLIQKKRDGLELSSEEIKWLIDGYVAGTVPDYQMSALAMAIYFKGMSTREISDLTMSMVATGEQIDlsaIPGIKVDKHST 84
Cdd:PRK00188 5 ELLEKLVEGEDLSEEEAEELMDAIMSGEATPAQIAAFLTALRVKGETVDEIAGAARAMREHAVPVP---DPDDAVDIVGT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500941435 85 GGVGDK---VTLILAPLVASFDIPVAKMSGRGL-GHTGGTlDKLESIkGYQIEVSQADFIKQVQDTGVAvigqsdnlvka 160
Cdd:PRK00188 82 GGDGANtfnISTAAAFVAAAAGVKVAKHGNRSVsSKSGSA-DVLEAL-GVNLDLSPEQVARCLEEVGIG----------- 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500941435 161 dkLLYA------LRDV--------TATV-DII-PLIAssvmskkiAAGADAILLdvtvgeGAFMKtvEEARVLAQTMVDL 224
Cdd:PRK00188 149 --FLFAplyhpaMKHVapvrkelgIRTIfNLLgPLTN--------PARPKRQLI------GVYSP--DLLEPMAEVLKRL 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500941435 225 G--KAV--------------GRKTVAVLTD-------------------MSQPVGtsiGNRLEILEAI-EILQGKGREDV 268
Cdd:PRK00188 211 GskRALvvhgsdgldeisltGPTTVAELKDgeireytltpedfglprapLEDLRG---GDPEENAAILrAVLQGKGPGAA 287
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 500941435 269 TEFICELAQIMLGLANVEKSIEE----VRQHIDNGAALKKFEEMVRA 311
Cdd:PRK00188 288 RDAVLLNAAAALYVAGKADDLKEgvelAREAIDSGAALAKLEELVAF 334
|
|
| |
