|
Name |
Accession |
Description |
Interval |
E-value |
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
13-438 |
2.13e-109 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 329.81 E-value: 2.13e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 13 FPLILNFAFPLLLGNLLQQTYSLMDAAIVGKFLGINALASVGASTSVVFLILGFCNGCCGGFGIPVAQKFGARDYGMMRR 92
Cdd:cd13138 2 LKTLLLFALPLLLSNLLQQLYNLVDLLIVGQFLGVAALAAVSNGSPIIFLLTAIGMGLSMGGTILISQYIGAKDEEKAKK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 93 FVAVSLQLAAVMSVVIAIVTSMFCSDILQMMQTPENILEDAYLYLLITFIGVPCTFFYNLLSSIIRALGDSKTPFWFLLF 172
Cdd:cd13138 82 AVGTLLVLFLILGIVLTILGLLFAPPILRLMNTPAEILELAVSYLRICFLGIPFIFGYNAYSAILRGLGDSKTPLYFVII 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 173 STILNILLDLFCILILDWGVAGAAVATVFSQGVSAVLCYLYMMRHFEILKGTPTEHKFRGALAKTLLYIGVPMGLQFSIT 252
Cdd:cd13138 162 ACVLNIILDLLFIAVFHMGVAGAALATVIAQAISVLLALYYLRKKKLPFKLSLKDFRFDKEILKEILKIGLPSALQQSLV 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 253 AIGSIMLQSANNALGTACVAAFTAAMRIKMFCMCPLESLGIAMATYSGQNYGAGKPKRIWLGIKASVLMMVIYCGFMFVV 332
Cdd:cd13138 242 SISFLIINSIVNSYGVVASAAYGIANKINSFAFLPPSAIGQAVSTFVAQNIGAGKIERAKKGLRTGIIISLIIGLIIILL 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 333 LMLGARTFALLFVdpAEWEILKDTELFLHISVSFFPVLGLLCILRYSIQGVGFTNLAMLSGVSEMIARIMVSLYAVPI-- 410
Cdd:cd13138 322 VFFFAPQLLGLFT--SDPEVIEIGAEYLRIYSIDYILFGILFVFNGLFRGLGKTKFPMIISILRLWLVRIPLAYLLSRlt 399
|
410 420
....*....|....*....|....*....
gi 501002816 411 -LGYLAVCFGDPTAWIFAVIFLIPAFIYV 438
Cdd:cd13138 400 gLGLFGIWLAMPISNILSAIICIIYYRKG 428
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
7-432 |
1.63e-88 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 276.25 E-value: 1.63e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 7 MTSGRPFPLILNFAFPLLLGNLLQQTYSLMDAAIVGKfLGINALASVGASTSVVFLILGFCNGCCGGFGIPVAQKFGARD 86
Cdd:COG0534 1 LTEGPILKLLLRLALPIILGNLLQSLYGLVDTIFVGR-LGTAALAAVGLAFPIFFLLIALGIGLGVGGTALVAQALGAGD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 87 YGMMRRFVAVSLQLAAVMSVVIAIVTSMFCSDILQMMQTPENILEDAYLYLLITFIGVPCTFFYNLLSSIIRALGDSKTP 166
Cdd:COG0534 80 REEARRVLGQALLLALLLGLLLTLLGLLFAPPLLRLLGADPEVLALARDYLRIILLGLPFLLLFNVLNGILRGLGDTKTP 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 167 FWFLLFSTILNILLDLFCILILDWGVAGAAVATVFSQGVSAVLCYLYMMRHFEILKGTPTEHKFRGALAKTLLYIGVPMG 246
Cdd:COG0534 160 MIIMLIGNVLNIVLDPLLIFGGGLGVAGAALATVISQAVSALLLLYYLFRKRSLLRLRLRDLRPDRKILKRILRIGLPAG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 247 LQFSITAIGSIMLQSANNALGTACVAAFTAAMRIKMFCMCPLESLGIAMATYSGQNYGAGKPKRIWLGIKASVLMMVIYC 326
Cdd:COG0534 240 LQQLAESLGFLVLNALVARLGTAAVAAYGIALRIESLAFMPALGLGQAAQPLVGQNLGAGDYDRARRAARLALLLALGIG 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 327 GFMFVVLMLGARTFALLFVDPAewEILKDTELFLHISVSFFPVLGLLCILRYSIQGVGFTNLAMLSGVSEMIARIMVSLY 406
Cdd:COG0534 320 LLLALLLFLFPEPIIGLFTDDP--EVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIISLLRLWLVRLPLAY 397
|
410 420
....*....|....*....|....*...
gi 501002816 407 AVPI--LGYLAVCFGDPTAWIFAVIFLI 432
Cdd:COG0534 398 LLAFlgLGLTGVWLALPIGEVLRALLLL 425
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
16-439 |
1.64e-62 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 208.52 E-value: 1.64e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 16 ILNFAFPLLLGNLLQQTYSLMDAAIVGKfLGINALASVGASTSVVFLILGFCNGCCGGFGIPVAQKFGARDYGMMRRFVA 95
Cdd:cd13137 3 IWSLAWPVILENLLQTLVGLVDVFMVGR-LGAEAIAAVGLATQVLWLLLVLNMALGTGTVALVSQSYGAGDYERARRALG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 96 VSLQLAAVMSVVIAIVTSMFCSDILQMMQTPENILEDAYLYLLITFIGVPCTFFYNLLSSIIRALGDSKTPFWFLLFSTI 175
Cdd:cd13137 82 QSLLLALLLSLPLALLGLLFAEPLLRLLGADPEVIALALTYLRIVLLGIPFFFLSLVGNAALRGAGDTKTPMYIMIIVNV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 176 LNILLDLFCIL----ILDWGVAGAAVATVFSQGVSAVLCYLYMMRHFEILKGTPTEHKFRGALAKTLLYIGVPMGLQFSI 251
Cdd:cd13137 162 LNIVLDYVLIFglwgFPGLGVAGAALATVISRVVGALLLLFLLLRGRLPIKISFKGFRLDRKIIKKLLRIGLPAGLEQLL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 252 TAIGSIMLQSANNALGTACVAAFTAAMRIKMFCMCPLESLGIAMATYSGQNYGAGKPKRIWLGIKASVLMMVIYCGFMFV 331
Cdd:cd13137 242 RSLGFLVLLAIVASYGTAALAAYQIGLRIESLAFMPGFGFSMAASTLVGQNLGAGDPDEARRYGKRALRLGVLFMGLLGL 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 332 VLMLGARTFALLFVDPAewEILKDTELFLHISVSFFPVLGLLCILRYSIQGVGFTNLAMLSGVSEMIarimvsLYAVPIL 411
Cdd:cd13137 322 LLFIFAPPLASLFTPDP--EVIELGVLYLRIVALSQPFLAISFVLSGALRGAGDTRPPLIINLISMW------LVRLPLA 393
|
410 420 430
....*....|....*....|....*....|.
gi 501002816 412 GYLAVCFGDPTAWIFAVIFL---IPAFIYVY 439
Cdd:cd13137 394 YLLGFVLGLGLTGIWLAMFVdtiVRAILLLY 424
|
|
| MATE_like_1 |
cd13140 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
10-349 |
1.13e-57 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240545 [Multi-domain] Cd Length: 435 Bit Score: 196.21 E-value: 1.13e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 10 GRPFPLILNFAFPLLLGNLLQQTYSLMDAAIVGKfLGINALASVGASTSVVFLILGFCNGCCGGFGIPVAQKFGARDYGM 89
Cdd:cd13140 1 GPILKTLLRLALPIMGTSFIQMAYNLTDMFWVGR-LGSDAVAAVGTAGFFVWLAYALALLSKIGAQVKVSQSIGAKDEKE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 90 MRRFVAVSLQLAAVMSVVIAIVTSMFCSDILQMMQ-TPENILEDAYLYLLITFIGVPCTFFYNLLSSIIRALGDSKTPFW 168
Cdd:cd13140 80 ARKYARNALQLNLLLGILYGLLLLLFAKPLIGFFNlGDAEVISLAITYLRIVALGLIFSFLNPVFTGIFNALGDSKTPFI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 169 FLLFSTILNILLDLFCILILD----WGVAGAAVATVFSQGVSAVLCYLYMMRHFEILKGTPTEHKFRGALAKTLLYIGVP 244
Cdd:cd13140 160 INAIGLVLNIILDPLLIFGFGpfpaLGVAGAALATVLAQAIVFLLFLYALKKKKGLFLKIRILKRPDRKYIKEILKLGLP 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 245 MGLQFSITAIGSIMLQSANNALGTACVAAFTAAMRIKMFCMCPLESLGIAMATYSGQNYGAGKPKRIWLGIKASVLMMVI 324
Cdd:cd13140 240 VALQSILFALISMILARIIASFGPVAIAAQKVGSQIESISWMTAEGFSTALAAFVGQNYGAGKYDRIRKGYKTALKIASA 319
|
330 340
....*....|....*....|....*
gi 501002816 325 YCGFMFVVLMLGARTFALLFVDPAE 349
Cdd:cd13140 320 IGLFATLLLFFFGEPLFSLFIPDPE 344
|
|
| MATE_like_12 |
cd13142 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
4-412 |
1.04e-54 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240547 [Multi-domain] Cd Length: 444 Bit Score: 188.55 E-value: 1.04e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 4 SREMTSGRPFPLILNFAFPLLLGNLLQQTYSLMDAAIVGKfLGINALASVGASTSVVFLILGFCNGCCGGFGIPVAQKFG 83
Cdd:cd13142 1 RENILEGSILRTLLKLAWPIIVSNLLQVAYNLADTFWLGR-LGADAVAAPSISWPLIFLFISLGGGLTVAGTALVAQYTG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 84 ARDYGMMRRFVAVSLQLAAVMSVVIAIVTSMFCSDILQM-MQTPENILEDAYLYLLITFIGVPCTFFYNLLSSIIRALGD 162
Cdd:cd13142 80 AGDYDKANKVAGQTFSFVIILSLILAVLGYILSRPLLLLlIGAPEEVYPLALAYLRIIFLGLPFMFIFFVFNSLLRGIGD 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 163 SKTPFWFLLFSTILNILLDLFCIL----ILDWGVAGAAVATVFSQGVSAVLCYLYMMRHFEILKGTPTEHKFRGALAKTL 238
Cdd:cd13142 160 TKTPMKIMFGSVLLNVILDPLLIFgigpFPGLGVAGAALATVISRGIAAVIGLYLLFKGRVGLKISLRDLKPDWEWLKKI 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 239 LYIGVPMGLQFSITAIGSIMLQSANNALGTACVAAFTAAMRIKMFCMCPLESLGIAMATYSGQNYGAGKPKR----IWLG 314
Cdd:cd13142 240 FRIGLPSSIEQSARALGFTVMTALVAGFGTVVVAAYGIGNRIISLVFLPAFGLARATSTMVGQNLGAGQIDRaeeiVKKA 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 315 IKASVLMMVIYCGFMFVVlmlgARTFALLFVDPAewEILKDTELFLHISVSFFPVLGLLCILRYSIQGVGFTNLAMLSGV 394
Cdd:cd13142 320 ALLIFLILVIGGVLAFLF----AEPIVRVFINDP--EVIKEGADFLRIVAPSFPFFGLFQVINGAFRGSGHTLTAMIISI 393
|
410
....*....|....*....
gi 501002816 395 SEM-IARIMVSLYAVPILG 412
Cdd:cd13142 394 LRLwVIRIPLAYLLAYVLG 412
|
|
| MATE_MepA_like |
cd13143 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
13-373 |
1.35e-53 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.
Pssm-ID: 240548 [Multi-domain] Cd Length: 426 Bit Score: 185.02 E-value: 1.35e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 13 FPLILNFAFPLLLGNLLQQTYSLMDAAIVGKFLGINALASVGASTSVVFLILGFCNGCCGGFGIPVAQKFGARDYGMMRR 92
Cdd:cd13143 3 GKLFLKFALPAIIGMLVNGLYNIVDGIFVGHGVGALALAAVNLVFPIIMLLMALGLMIGVGGASLISRRLGAGDREKANR 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 93 FVAVSLQLAAVMSVVIAIVTSMFCSDILQMMQTPENILEDAYLYLLITFIGVPCTFFYNLLSSIIRALGDSKTPFWFLLF 172
Cdd:cd13143 83 IFSTALLLSLILGLLLTILGLLFLDPLLRLLGASGELLPYAVDYLRIILLGAPFTILSSVLNNLLRAEGKPKLAMLGMLI 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 173 STILNILLDLFCILILDWGVAGAAVATVFSQGVSAVLCYLYMMRHFEILKGTPTEHKFRGALAKTLLYIGVPMGL-QFSI 251
Cdd:cd13143 163 GAVLNIILDPLFIFVLGLGIAGAALATVIAQLISLLLLLLYFFRGKSLLKLSLLRFKLSLKIIKEILALGFPSFLmQLSS 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 252 TAIGSIMLQSANNALGTACVAAFTAAMRIKMFCMCPLESLGIAMATYSGQNYGAGKPKRIWLGIKASVLMMVIYCGFMFV 331
Cdd:cd13143 243 SVVTIVLNLTLLGYGGDIGVAAFGIVTRILTFLFLPLIGLSQGLQPIIGYNYGAGNYDRVKQALKLALIVALIYGLVLFL 322
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 501002816 332 VLMLGARTFALLFVDPAewEILKDTELFLHISVSFFPVLGLL 373
Cdd:cd13143 323 ILLLFPEQIVSLFTDDP--ELIALAARILRIFLLAFPLAGIN 362
|
|
| MATE_MJ0709_like |
cd13147 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, ... |
16-414 |
2.58e-43 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, similar to Methanocaldococcus jannaschii MJ0709; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240552 [Multi-domain] Cd Length: 441 Bit Score: 157.70 E-value: 2.58e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 16 ILNFAFPLLLGNLLQQTYSLMDAAIVGKfLGINALASVGASTSVVFLILGFCNGCCGGFGIPVAQKFGARDYGMMRRFVA 95
Cdd:cd13147 11 IIKLSIPMIIAMLLQTLYNLVDAIWVAG-LGADALAAIGFVFPLFMIIIGLGNGLGAGASSAISRRIGAKDKEGADNAAV 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 96 VSLQLAAVMSVVIAIVTSMFCSDILQMMQTpENILEDAYLYLLITFIGVPCTFFYNLLSSIIRALGDSKTPFWFLLFSTI 175
Cdd:cd13147 90 HSILLGLIISIILTIVLLPFLEPILVLMGA-GEVLDLAVDYGRIIFLGSIFLIFNNVAYGILRGEGDTKRAMYAMVAGSI 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 176 LNILLDLFCILILDWGVAGAAVATVFSQGVSA-VLCYLYMMRHFEILKGTPTEHKFRGALAKTLLYIGVPMGLQFSITAI 254
Cdd:cd13147 169 LNIILDPIFIYTLGLGIAGAAWATVISMLISSlVLLYWFFVKKDTYVSLSLKNFKFDKKIVKDILKVGIPASLEQLIMSV 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 255 GSIMLQS-ANNALGTACVAAFTAAMRIKMFCMCPLESLGIAMATYSGQNYGAGKPKRIWLGIKASVLMMVIYCGFMFVVL 333
Cdd:cd13147 249 LMIILNLiLVIVAGTDGVAVYTAGWRIVSFAIIPLIGIATAVTSVTGAAYGARNYEKLKTAYNYSIKLGLIIELIIAILI 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 334 MLGARTFALLFVDPAEWEILKDTEL-FLHISVSFFPVLGLLCILRYSIQGVGftnlamlSGVSEMIARIMVSLYAVPILG 412
Cdd:cd13147 329 FIFAPQIAYLFTYSEESAHLAPEIVaFLRIMCLFLPFVPFGMMSSSMFQGIG-------KGLTSLIITILRELIFQVLFA 401
|
..
gi 501002816 413 YL 414
Cdd:cd13147 402 YL 403
|
|
| MATE_like_7 |
cd13133 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
16-444 |
1.26e-41 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240538 [Multi-domain] Cd Length: 438 Bit Score: 153.07 E-value: 1.26e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 16 ILNFAFPLLLGNLLQQTYSLMDAAIVGKfLGINALASVGASTSVVFLILGFCNGCCGGFGIPVAQKFGARDYGMMRRFVA 95
Cdd:cd13133 7 ILKIALPLVLSMLSQTVMGFTDRAFLGR-LSEVALAASGPAGVLYFAILMLFFGLSSGVQVFVAQYNGAGRYSRIGRVLW 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 96 VSLQLAAVMSVVIAIVTSMFCSDILQMMQTPENILEDAYLYLLITFIGVPCTFFYNLLSSIIRALGDSKTPFWFLLFSTI 175
Cdd:cd13133 86 QGLYFSLLLAPLLALLSALAAPLLFLLLGHSPEVQALEVEYFRIRILGAPFSLLGAALRAFFSGIGRTRVVMVANLVMVV 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 176 LNILLDLFCIL----ILDWGVAGAAVATVFSQGVSAVLCYLYMMRH-FEILKGTPTEHKFRGALAKTLLYIGVPMGLQFS 250
Cdd:cd13133 166 VNIVLDYALIFgklgFPAMGIAGAAIATVIAEAVSLLFFLLLLFRRkNRRRFGLRRAWRFDRELLRRILRLGLPSGLQFF 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 251 ITAIGSIMLQSANNALGTACVAAFTAAMRIKMFCMCPLESLGIAMATYSGQNYGAGKPKRIWLGIKASVLMMVIYCGFMF 330
Cdd:cd13133 246 LDVGAFTVFFLLIGRLGTTELAATNIVFSINSLAFLPMIGLGIAVSSLVGQALGAGRPDLAMRVTRRGLKLALAYMLLLG 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 331 VVLMLGARTFALLFVDPAEWE-ILKDTELFLHISVSFFPVLGLLCILRYSIQGVGFTNLAMLSGVsemiarIMVSLYAVP 409
Cdd:cd13133 326 ILFLLFPELLLSIFTPGADFAlIAELAVPLLRFVAAYILFDALALVFAGALRGAGDTRFVMLAEL------IVAWLYLLP 399
|
410 420 430
....*....|....*....|....*....|....*.
gi 501002816 410 ILGYLAVCFGDPT-AWIFAVIFLIPAFIYVYGRIKR 444
Cdd:cd13133 400 PAYLLVVLGAGLAgAWTVETVYVIVLALIFLLRFRS 435
|
|
| MATE_like_8 |
cd13134 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
16-429 |
4.18e-41 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240539 [Multi-domain] Cd Length: 438 Bit Score: 151.89 E-value: 4.18e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 16 ILNFAFPLLLGNLLQQTYSLMDAAIVGKfLGINALASVGASTSVVFLILGFCNGCCGGFGIPVAQKFGARDYGMMRRFVA 95
Cdd:cd13134 5 LFALAWPIFIELLLQMLLGTIDTFMLSR-YSDNAVAAVGVANQILFLLILIFSFISTGTSILIAQYLGAKDKKKARQIAG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 96 VSLQLAAVMSVVIAIVTSMFCSDILQMMQTPENILEDAYLYLLITFIGVPCTFFYNLLSSIIRALGDSKTPFWFLLFSTI 175
Cdd:cd13134 84 VALLFNLLLGLVFSLLLLFFGAELLRLMGLPPELLALGSTYLRIVGGSLFLQALSLTLSAILRSHGRTKIPMYVSLIMNI 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 176 LNILLDLFCIL----ILDWGVAGAAVATVFSQGVSAVLCYLYMMRHFEILKGTPTEHKFRGALAKTLLYIGVPMGL---- 247
Cdd:cd13134 164 LNIVGNYLLIFgwfgLPKLGVAGVAISTVISRAVGLVLLFILLFRKLKIRFRLKDLRPFPKKLLKKILKIGLPSAGeels 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 248 -QFSITAIGSIMlqsanNALGTACVAAFTAAMRIKMFCMCPLESLGIAMATYSGQNYGAGKPKRIW-LGIKASVLMMVIY 325
Cdd:cd13134 244 yNLSQTVITAFI-----ARLGTAALAARTYASNISMFVFLFSLAIGQATQIIVGHLVGAGDFDEAYkRVLKSLKIGLLVS 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 326 CGFMFVVLMLGARTFALLFVDPaewEILKDTELFLHISVSFFPVLGLLCILRYSIQGVGFTNLAMLSGVSEMIarimvsL 405
Cdd:cd13134 319 LAVALLLALFREPILGLFTDDP---EIIALGKTLLLISILLEPGRAFNIVLIGSLRAAGDARFPVLIGIISMW------G 389
|
410 420
....*....|....*....|....
gi 501002816 406 YAVPILGYLAVCFGDPTAWIFAVI 429
Cdd:cd13134 390 ISVPLAYLLGIVLGLGLLGVWIAF 413
|
|
| MATE_like_2 |
cd13149 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
6-349 |
1.34e-39 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240554 [Multi-domain] Cd Length: 434 Bit Score: 147.45 E-value: 1.34e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 6 EMTSGRPFPLILNFAFPLLLGNLLQQTYSLMDAAIVGKfLGINALASVGASTSVVFLILGFCNGCCGGFGIPVAQKFGAR 85
Cdd:cd13149 1 KLTEGSIPRHLIKLTLPMIFGILAMLIFNLTDTFFVGK-LGTKELAAISFTFPVVLFLNSLTIGLGIGASAVISRAIGAG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 86 DYGMMRRFVAVSLQLAAVMSVVIAIVTSMFCSDILQMMQTPENILEDAYLYLLITFIGVPCTFFYNLLSSIIRALGDSKT 165
Cdd:cd13149 80 DRNKAKRLATDSLILSLLLSVIVSLLGLFTIPPLFSLLGASGEILPLIVEYMAIWYLGLVFLVLPMVGNAIIRATGDTKR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 166 PFWFLLFSTILNILLDLfcILILDW------GVAGAAVATVFSQGVSAVLCYLYMMRHFEILKGTPTEHKFRGALAKTLL 239
Cdd:cd13149 160 PSLVMLGAALVNVILDP--ILIFGFgpipgmGIAGAAIATVISRALGLGAALYFLHYHHRLIDFSEPSLKALFRSWKDIL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 240 YIGVPMGLQFSITAIGSIMLQSANNALGTACVAAFTAAMRIKMFCMCPLESLGIAMATYSGQNYGAGKPKRIWLGIKASV 319
Cdd:cd13149 238 SIGIPAALSNILTPLSAAFITALVATYGPAAVAAFGVATRIESFAFIIVMALSSALGPFVGQNWGAGQYERVQEGLKISL 317
|
330 340 350
....*....|....*....|....*....|
gi 501002816 320 LMMVIYCGFMFVVLMLGARTFALLFVDPAE 349
Cdd:cd13149 318 KFSLIYGAILGIVLALFAGWLASLFSAEPE 347
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
20-436 |
3.11e-39 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 146.31 E-value: 3.11e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 20 AFPLLLGNLLQQTYSLMDAAIVGKFLGiNALASVGASTSVVFLILGFCNGCCGGFGIPVAQKFGARDYGMMRRFVAVSLQ 99
Cdd:cd12082 1 AAPLLLSMLLQTLYNLVDTFFLGRLLG-DALAAVGLAFPLIALLIALGVGLSVGTSALISQAIGAGDEEKARRVLVQSIV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 100 LAAVMSVVIAIVTSMFCSDILQMMQTPENILEDAYLYLLITFIGVPCTFFYNLLSSIIRALGDSKTPFWFLLFSTILNIL 179
Cdd:cd12082 80 LAILLGLLLAALLLFFSPLILSLLGAEEEVIELAATYLTILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSNLLNIL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 180 LDLFCILIL---DWGVAGAAVATVFSQGVSAVLCYLYMMRHFEILKGTPTEHKFRGALAKTLLYIGVPMGLQFSITAIGS 256
Cdd:cd12082 160 LDPLLIFGLgppELGIAGAALATVISYVIGALLLLIYLRKGKKILKFKLSLLKPDLELLRRLLRIGLPSAIQNSLLSLGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 257 IMLQS-ANNALGTACVAAFTAAMRIKMFCMCPLESLGIAMATYSGQNYGAGKPKRIWLGIKASVLMMVIYCGFMFVVLML 335
Cdd:cd12082 240 LIIVAiVAAFGGAAALAAYTVAFRIASLAFMPALGLAQAALPVVGQNLGAGNFDRARRITWVALLIGLLIGAVLGLLILL 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 336 GARTFALLFVDPAEWeiLKDTELFLHISVSFFPVLGLLCILRYSIQGVGFTNLAMLSGVSEMIARIMVSLYAVPILGY-- 413
Cdd:cd12082 320 FPEPILSLFTNDPEF--LELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSLIVSLLSYWVVRLPLAYVLAYLGLgl 397
|
410 420
....*....|....*....|...
gi 501002816 414 LAVCFGDPTAWIFAVIFLIPAFI 436
Cdd:cd12082 398 YGIWLALVISLILAALVLLLFFR 420
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
22-346 |
2.31e-36 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 136.61 E-value: 2.31e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 22 PLLLGNLLQQTYSLMDAAIVGKfLGINALASVGASTSVVFLILGFCNGCCGGFGIPVAQKFGARDYGMMRRFVAVSLQLA 101
Cdd:TIGR00797 1 PAILANILQPLLGLVDTAFVGH-LGPVDLAAVSLGSSVFMFLFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 102 AVMSVVIAIVTSMFCSDILQMMQTPENILEDAYLYLLITFIGVPCTFFYNLLSSIIRALGDSKTPFWFLLFSTILNILLD 181
Cdd:TIGR00797 80 LLLGLPVLLVGYFFIDPLLSLMGADGEVAELAQDYLRILILGIPAYLLNFVLRGFLRGQGDTKTPMYITLIGNVINIILN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 182 LfcILILD----WGVAGAAVATVFSQGVSAVLCYLYMMRHFEILKGTPTEHKFRGALAKTLLYIGVPMGLQFSITAIGSI 257
Cdd:TIGR00797 160 Y--ILIFGkfgfLGIVGAALATVISYWLMFLLLLYYIKKAKKIGLKWEGLLKPDWEVLKRLLKLGLPIAFRVILESLSFA 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 258 MLQSANNALGTACVAAFTAAMRIKMFCMCPLESLGIAMATYSGQNYGAGKPKRIWLGIKASVLMMVIYCGFMFVVLMLGA 337
Cdd:TIGR00797 238 LLALLVARLGSIALAAHQIALNVESLLFMPAFGFGIAVSILVGQALGAGDPKRAKEVARVALKLSLLLGLVLAIILILFR 317
|
....*....
gi 501002816 338 RTFALLFVD 346
Cdd:TIGR00797 318 EFIARLFTN 326
|
|
| MATE_like_14 |
cd13139 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
1-346 |
8.12e-33 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240544 [Multi-domain] Cd Length: 448 Bit Score: 129.27 E-value: 8.12e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 1 MATSREMTSGRPFPLILNFAFPLLLGNLLQQTYSLMDAAIVGKfLGINALASVGASTSVVFLILGFCNGCCGGFGIPVAQ 80
Cdd:cd13139 1 SGKEQDFTSGSLNRAIFLLAIPMVLEMVMESLFAVVDLYFVSR-LGALAIATVGLTESVLTIVYSIAIGLSMAATALVAR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 81 KFGARDYGMMRRFVAVSLQLAAVMSVVIAIVTSMFCSDILQMMQTPENILEDAYLYLLITFIGVPCTFFYNLLSSIIRAL 160
Cdd:cd13139 80 RIGEKDPEGAGFAAVQAILLGVALSLILSILGYFFAEDILSLMGASPAVIAEGYGYTRIMFGGNGFIMLLFLINGIFRGA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 161 GDSKTPFWFLLFSTILNILLDLFCIL----ILDWGVAGAAVATVFSQGVSAVLCYLYMMRHFEILKGTPTEHKFRGALAK 236
Cdd:cd13139 160 GDAAIAMRSLWLANGLNIILDPLFIFglgpIPAMGVTGAAIATTIGRSIGVLYQLYHLFKGKGRIQIRRRHLKLDWAIIK 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 237 TLLYIGVPMGLQFSITAIGSIMLQSANNALGTACVAAFTAAMRIKMFCMCPLESLGIAMATYSGQNYGAGKPKRIWLGIK 316
Cdd:cd13139 240 KIIKIAVGGILQFLIASSSWIFLVRIIAEFGSTALAGYTIAIRIIMFALLPAWGLSNAAATLVGQNLGAGQPDRAEKSVW 319
|
330 340 350
....*....|....*....|....*....|
gi 501002816 317 ASVLMMVIYCGFMFVVLMLGARTFALLFVD 346
Cdd:cd13139 320 RAGKYNMVFLGIVSLVFFLFAEPLVSFFTT 349
|
|
| MATE_like_4 |
cd13144 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
7-430 |
1.11e-30 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240549 [Multi-domain] Cd Length: 434 Bit Score: 122.73 E-value: 1.11e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 7 MTSGRPFPLILNFAFPLLLGNLLQQTYSLMDAAIVGKfLGINALASVGASTSVVFLILGFCNGCCGGFGIPVAQKFGARD 86
Cdd:cd13144 1 MGSGPVLRLLLTMSIPAMISMLFQALYNIVDSIFVAR-LGENALTAVSLAFPIQNLMIAVAVGTGVGVNALLSRSLGEKD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 87 YGMMRRFVAVSLQLAAVMSVVIAIVTSMFCSDILQMMQTPENILEDAYLYLLITFIGVPCTFFYNLLSSIIRALGDSKTP 166
Cdd:cd13144 80 QKEANKAANNGLLLALLSYLLFLLLGLFGVKPFFRLFTDDPEILEYGYAYLSWCVIFSFGMFFQILCEKVLQSTGNTITP 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 167 FWFLLFSTILNILLDLFCIL----ILDWGVAGAAVATVFSQGVSAVLCYLYMMRHFEILKGTPTEHKFRGALAKTLLYIG 242
Cdd:cd13144 160 MIAQLIGAIINIILDPILIFglfgFPAMGIAGAAIATVIGQILAMFLAFFFLLRKNKDVQPDLRLFRPSLRIIKEIYAVG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 243 VPMGLQFSITAIGSIMLQSANNALGTACVAAFTAAMRIKMFCMCPLESLGIAMATYSGQNYGAGKPKRIWLGIKASVLMM 322
Cdd:cd13144 240 LPSIIMQAISSVMVFGLNKILAGFGPTAVAVFGIYFKLQSFVFMPVFGLNNGLIPIVAYNYGAGNKDRIREAIKYAILIA 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 323 VIYCGFMFVVLMLGARTFALLFvDPAEwEILKDTELFLHISVSFFPVLGLLCILRYSIQGVGFTNLAMLSGvsemIARIM 402
Cdd:cd13144 320 VVIMLAGGLLFQLFPDQLLGLF-NASE-EMLAIGVPALRIISLSFLFAALSIILSGLFQALGRGVYSLIIS----VARQL 393
|
410 420
....*....|....*....|....*...
gi 501002816 403 VSLYavpilgylavcfgdPTAWIFAVIF 430
Cdd:cd13144 394 VVLL--------------PLAWLLAKMF 407
|
|
| MATE_NorM_like |
cd13131 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio ... |
16-349 |
2.31e-30 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Vibrio cholerae NorM and functions most likely as a multidrug efflux pump, removing xenobiotics from the interior of the cell. The pump utilizes a cation gradient across the membrane to facilitate the export process. NorM appears to bind monovalent cations in an outward-facing conformation and may subsequently cycle through an inward-facing and outward-facing conformation to capture and release its substrate.
Pssm-ID: 240536 [Multi-domain] Cd Length: 435 Bit Score: 121.84 E-value: 2.31e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 16 ILNFAFPLLLGNLLQQTYSLMDAAIVGKfLGINALASVGASTSVVFLILGFCNGCCGGFGIPVAQKFGARDYGMMRRFVA 95
Cdd:cd13131 5 LLRLALPILIAQLAQMAMGFVDTVMAGR-LGADDLAAVALGSSLWFPVFTFGMGLLLAVTPLVAQAHGAGDRRRIRRAVR 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 96 VSLQLAAVMSVVIAIVtSMFCSDILQMMQTPENILEDAYLYLLITFIGVPCTFFYNLLSSIIRALGDSKTPFWFLLFSTI 175
Cdd:cd13131 84 QGLWLALLLSLPLMLL-LWLAPPILPLMGQEPEVAAIARGYLLALAWGIPPALLFQVLRSFLDALGRTRPAMVITLLALV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 176 LNILLDLfcILILDW------GVAGAAVATVFSQGVSAVLCYLYMMRH--FEILKGTPTEHKFRGALAKTLLYIGVPMGL 247
Cdd:cd13131 163 LNIPLNY--VLIFGKfglpalGGAGAGLATAIVYWLMFLALAFYIRRHkrFRRYRLFARFWRPDWARLKELLRLGLPIGL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 248 QF----SITAIGSIMLqsanNALGTACVAAFTAAMRIKMFC-MCPLeSLGIAMATYSGQNYGAGKPKRIWLGIKASVLMM 322
Cdd:cd13131 241 TIffevSLFAAVALLM----GRLGTTVLAAHQIALNFASLLfMVPL-GISMAATVRVGFALGAGDPADARRAGLVGLGLG 315
|
330 340
....*....|....*....|....*..
gi 501002816 323 VIYCGFMFVVLMLGARTFALLFVDPAE 349
Cdd:cd13131 316 VGFAALTALLLLLFPEQIAGLYTNDPA 342
|
|
| MATE_like_5 |
cd13145 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
15-432 |
2.28e-29 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240550 [Multi-domain] Cd Length: 440 Bit Score: 119.24 E-value: 2.28e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 15 LILNFAFPLLLGNLLQQTYSLMDAAIVGKfLGINALASVGASTSVVFLILGFCNGCCGGFGIPVAQKFGARDYGMMRRFV 94
Cdd:cd13145 10 LIRKLAIPASVGFFFNTMFNVVDTFFAGK-ISTEALAALSLSFPIFFIIIAIGVGIGTGTTALIGNALGAGDRRKARRYA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 95 AVSLQLAAVMSVVIAIVTSMFCSDILQMMQTPENILEDAYLYLLITFIGVPCTFFYNLLSSIIRALGDSKTPFWFLLFST 174
Cdd:cd13145 89 AQGLSFGIILAILLTVIGLFAAPPLFRLLGAEGDYLDLALEYMDVIFAGSIFFLLNFGLNGILNAQGDTKSYRNFLIIGF 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 175 ILNILLDLFCI----LILDWGVAGAAVATVFSQGVSAVlcYLYM-MRHFEILKGT-PTEHKFRGALAKTLLYIGVPMGLQ 248
Cdd:cd13145 169 FLNIILDPLFIfgggGIPAMGVSGIALATIISQFIGMF--YLLYkVRKSGIISGCrLRDFIPRLDVYKEILKQGFPASLN 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 249 FSITAIGSIMLQSANNALGTACVAAFTAAMRIKMFCMCPLESLGIAMATYSGQNYGAGKPKRIWLGIKASVLMMVIYCGF 328
Cdd:cd13145 247 MMTIGLGIFVITYFVGQFGDEAVAAYGIALRIEQILLLPTIGLNTAVLSIAGQNFGAKKYDRVRETYKKALKYGFVIMVV 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 329 MFVVLMLGARTFALLFVDPAewEILKDTELFLHISVSFFPVLGLLcilrysiqgvgFTNLAMLSGVSEMIARIMVSLY-- 406
Cdd:cd13145 327 ATVFLLFFAEPLMSLFTNDP--AVIAIGAGYLRIDALIFYAYVVL-----------FISVSVLQGLKRPIFALWIGLYrq 393
|
410 420
....*....|....*....|....*....
gi 501002816 407 ---AVPILGYLAVCFGDPTAWIFAVIFLI 432
Cdd:cd13145 394 lvgPALVFWLLVNVLGLGVTGIWWGIFTI 422
|
|
| MATE_DinF_like |
cd13136 |
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE) ... |
16-346 |
2.62e-29 |
|
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240541 [Multi-domain] Cd Length: 424 Bit Score: 118.82 E-value: 2.62e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 16 ILNFAFPLLLGNLLQQTYSLMDAAIVGKFLGINALASVGAST---SVVFLILGFCNGCCGGFgipVAQKFGARDYGMMRR 92
Cdd:cd13136 5 ILALALPAILSNITVPLLGLVDTAVVGHLGSAAYLGAVALGTtifNTLFWLFGFLRMGTTGL---VAQALGAGDREEAIA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 93 FVAVSLQLAAVMSVVIAIVTSMFCSDILQMMQTPENILEDAYLYLLITFIGVPCTFFYNLLSSIIRALGDSKTPFWFLLF 172
Cdd:cd13136 82 LLVRALLLALAIGLLLILLQSPLLALALLLLGASAAVAALARQYLRIRILGAPAVLLNYVATGWFRGLQDTRTPLILQIV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 173 STILNILLDLFCILILDWGVAGAAVATVFSQGVSAVLCYLYMMRHFEILKGTPTEHKFRGALAKTLLYIGVPMglqfsit 252
Cdd:cd13136 162 GNVVNIVLDPLFVFGLGWGVAGAALATVIAQYLGALLGLWLLRRRVRLLGKSLSRRLPSKAALKRLFKLNRDI------- 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 253 AIGSIMLQSANNA-------LGTACVAAFTAAMRIKMFCMCPLESLGIAMATYSGQNYGAGKPKRIWLGIKASVLMMVIY 325
Cdd:cd13136 235 FIRTLALLAAFLFftalaarLGDVILAANQILLQFWLLSSYFLDGFAYAAEALVGRALGAGDRKAARRVARRLLQWGLGL 314
|
330 340
....*....|....*....|.
gi 501002816 326 CGFMFVVLMLGARTFALLFVD 346
Cdd:cd13136 315 GVLLALLFFLGGEPIIRLFTD 335
|
|
| MATE_like_13 |
cd13141 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
5-406 |
1.14e-25 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240546 [Multi-domain] Cd Length: 443 Bit Score: 108.56 E-value: 1.14e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 5 REMTSGRPFPLILNFAFPLLLGNLLQQTYSLMDAAIVGKfLGINALASVGASTSVVFLILGFCNGCCGGFGIPVAQKFGA 84
Cdd:cd13141 2 KDLTQGSIPKHIISMALPIAIGMIIQTLYFLVDLYFVGQ-LGDAALAGVSLAGNVMFFVMALTQVLNVGTAALVSHAVGR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 85 RDYGMMRRFVAVSLQLAAVMSVVIAIVTSMFCSDILQMMQTPENILEDAYLYLLITFIGVPCTFFYNLLSSIIRALGDSK 164
Cdd:cd13141 81 KDQGEANAVFNQSLLLAAVLGLVVLVLGYLFGRLYLETLAADAATVEAATTYLYWFIPSLALQFILTVLGAALRGTGIVK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 165 TPFWFLLFSTILNILLDlfCILILDW------GVAGAAVATVFSQGVSAVLCYLYMMRHFEILKGTPTEHKFRGALAKTL 238
Cdd:cd13141 161 PFMVIQILAVLLNIILA--PILITGWgtgralGVAGAGLASSISVAIAVVLLLYYFLRLEKYLRLDLALWRPDLPTWKRL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 239 LYIGVPMGLQFSITAIGSIMLQSANNALGTACVAAFTAAMRIKMFCMCPLESLGIAMATYSGQNYGAGKPKRIWLGIKAS 318
Cdd:cd13141 239 LKIGLPSGGEFLLTFVYMAVIYWALRPFGAAAQAGFGIGSRIMQSLFLPAMAIAFAAPAIAGQNFGAGNYDRVRETFRIT 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 319 VLMMVIYCGFMFVVLMLGARTFALLFVDPAewEILKDTELFLHISVSFFPVLGLLCILRYSIQGVGFTNLAMLSGVSEMI 398
Cdd:cd13141 319 AILTTALMLVLTLLCQLVPELLVTPFSDDA--AVIAVAATFLRYVSWNFVAAGLVFTCSGMFQALGNTWPSLLSSASRLL 396
|
....*...
gi 501002816 399 ARIMVSLY 406
Cdd:cd13141 397 TFALPVIW 404
|
|
| MATE_like_6 |
cd13146 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
7-348 |
6.22e-24 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240551 [Multi-domain] Cd Length: 433 Bit Score: 103.64 E-value: 6.22e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 7 MTSGRPFPLILNFAFPLLLGNLLQQTYSLMDAAIVGKFLGINA--LASVGASTSVVFLILGFCNGCCGGFGIPVAQKFGA 84
Cdd:cd13146 1 MFSGPISPLLIRLALPILIGQLFQLLYNITDTIWISMIDPSDPalVGGIGLVFPLGMIFLALGNGIQVGVSSLLARAIGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 85 RDYGMMRRFVAVSLQLAAVMSVVIAIVTSMFCSDILQMMQTPENILEDAYLYLLITFIGVPCTFFYNLLSSIIRALGDSK 164
Cdd:cd13146 81 QRAKELDQAADSGLALALLAATVIVVLGYIFAEPLLQLLGAKGLLLEYALEYFYYSLPGVPFIMLIGVLMGVLQGEGRTK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 165 TPFWFLLFSTILNILLDLFCILILDWGVAGAAVATVFSQGVSavlcYLYMMRHFEILKGTPTEH----KFRGALAKTLLY 240
Cdd:cd13146 161 YMMMAMLIGTVVNIVLDPILIFVFDMGVKGAALATVLAQAIS----LLYLLYVFLIGKSNVTIHiklsNISSSVIVEILR 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 241 IGVPMGLQFSITAIGSIMLQSANNALGTACVAAFTAAMRIKMFCMCPLESLGIAMATYSGQNYGAGKPKRIWLGIKASVL 320
Cdd:cd13146 237 VGLPQMLLQLISSISFLIYNRIIIDIDPVAMTAFTLVGRLDQFILIPIFAISSALLTIAGQNWGRGNYDRMLQILMTAVI 316
|
330 340
....*....|....*....|....*....
gi 501002816 321 MMVIYCGFMFVVLMLGA-RTFALLFVDPA 348
Cdd:cd13146 317 LGIVVVLVLVLGYVLVApWLFSLFTTVPE 345
|
|
| MATE_like_3 |
cd13148 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
5-413 |
3.84e-23 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240553 [Multi-domain] Cd Length: 441 Bit Score: 101.19 E-value: 3.84e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 5 REMTSGRPFPLILNFAFPLLLGNLLQQTYSLMDAAIVGkFLGINALASVGASTSVVFLILGFCNGCCGGfGI--PVAQKF 82
Cdd:cd13148 3 RALLTAPILPTLLRLALPNILALLVQTLVGLAETYFVG-QLGTDALAGVALVFPLLMLTQMMSNGAMGG-GVssAIARAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 83 GARDYGMMRRFVAVSLQLAAVMSVVIAIVTSMFCSDILQMMQTPENILEDAYLYLLITFIGVPCTFFYNLLSSIIRALGD 162
Cdd:cd13148 81 GAGDRERAEALVWHALVIALAGGLVFSLLFLLFGPALYRLLGGRGEALDAALAYSNVLFSGAILIWLVNLLAAALRGTGN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 163 SKTPFWFLLFSTILNILLDLFCIL----ILDWGVAGAAVATVFSQGVSAVLCYLYMMRHFEILKGTPTEHKFRGALAKTL 238
Cdd:cd13148 161 MRVPALVTLVGAVVQIPLSPGLILgwgpLPRLGVAGAAVAAVLYYALAALVLLRYLASGRSRLRLRLRALRLERRLFRDI 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 239 LYIGVPMGLQFSITAIGSIMLQSANNALGTACVAAFTAAMRIKMFCMCPLESLGIAMATYSGQNYGAGKPKRI----WLG 314
Cdd:cd13148 241 LRVGLLAALSPLQTNLTVLLLTGLVGRFGTAALAGYGIGSRLEFLLIPLVFGLGAAMTAMVGMNIGAGQIARArriaWTG 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 315 ikasVLMMVIYCGFMFVVLMLGARTFALLFV-DPAeweILKDTELFLHISVSFFPVLGLLCILRYSIQGVGFTNLAMLSG 393
Cdd:cd13148 321 ----ALMAAVLAGAIGLVLALFPELWLGLFThDPA---VLAAGASYLRIVGPFYGFFGLGLALYFASQGAGRMLWPVLAG 393
|
410 420
....*....|....*....|
gi 501002816 394 VSEMIARIMVSLYAVPILGY 413
Cdd:cd13148 394 TLRLLIAAGGGWIAVALFGA 413
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
22-181 |
5.86e-21 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 89.16 E-value: 5.86e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 22 PLLLGNLLQQTYSLMDAAIVGKfLGINALASVGASTSVVFLILGFCNGCCGGFGIPVAQKFGARDYGMMRRFVAVSLQLA 101
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGH-LGAVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 102 AVMSVVIAIVTSMFCSDILQMMQTPENILEDAYLYLLITFIGVPCTFFYNLLSSIIRALGDSKTPFWFLLFSTILNILLD 181
Cdd:pfam01554 80 LLLSLPIALLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISLLLNIPLN 159
|
|
| MATE_like_9 |
cd13135 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
16-405 |
8.59e-21 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240540 [Multi-domain] Cd Length: 429 Bit Score: 94.28 E-value: 8.59e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 16 ILNFAFPLLLGNLLQQTYSLMDAAIVGKfLGINALASVGASTSVVFLILGFCNGCCGGFGIPVAQKFGARDYGMMRRFVA 95
Cdd:cd13135 3 INHIAIPLILQNLVSQLQMLVDRAFLGR-ISIRYYSAVGNVTTPFNTITGFLGSISIGFTILGSQSVGAKDIKRINDYAI 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 96 VSLQLAAVMSVVIAIVTSMFCSDILQMMQTPENILEDAYLYLLITFIGVPCTFFYNLLSSIIRALGDSKTPFWFLLFSTI 175
Cdd:cd13135 82 SSIVYNSIIGVILFLLWLFGARIIFVLFGVDGQILGYSINYVRIFSIYLLLLGILFTFSSILQGIGETKPIMYGGIIKNL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 176 LNILLDLFCIL----ILDWGVAGAAVATVFSQGVSAVLCYLYMMRHFEILKGTPTEHKFRGALA--KTLLYIGVPMGLQF 249
Cdd:cd13135 162 LNVILDYVLIFgnfgFPRLGIIGAAIATTIANVLNLIILVYLCRKIKKLTFKLSNTKVLKANIRpyKFTIKLGLPLGGEE 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 250 SITAIGSIMLQSANNALGTACVAAFTAAMRIKMFCMCPLESLGIAMATYSGQNYGAGKPKRIWLGIKASVLMMVIYCGFM 329
Cdd:cd13135 242 FLWNIGNLAVIRILNRIGELALGIYTLVFGIENIVLMPMYGYSSAALTLVGESIGKKDLKEALRIGNICLGLGLLIYIAA 321
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 501002816 330 FVVLMLGARTFALLFVDPAEWeILKDTELFLHISVSFFPVLgLLCILRYSIQGVGFTNLAMLSgvSEMIARIMVSL 405
Cdd:cd13135 322 AIVFLAFPYKILSLFTNDPEL-INYSIPYLIFIIIILFFKS-INIVYGFAIRAIGDTKWMLYT--QIIGTIIVVSV 393
|
|
| MATE_eukaryotic |
cd13132 |
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ... |
16-349 |
1.43e-18 |
|
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.
Pssm-ID: 240537 [Multi-domain] Cd Length: 436 Bit Score: 87.63 E-value: 1.43e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 16 ILNFAFPLLLGNLLQQTYSLMDAAIVGKfLGINALASVGASTSVVFL-ILGFCNGCCGGFGIPVAQKFGARDYGMmrrfV 94
Cdd:cd13132 5 LLRLAAPLVLTSLLQYSLSVVSVVFVGH-LGKLELAAASLASSFANVtGFSILLGLASALDTLCGQAFGAKNYKL----V 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 95 AVSLQLAAVMSVVIAIVTS---MFCSDILQMMQTPENILEDAYLYLLITFIGVPCTFFYNLLSSIIRALGDSKTPFWFLL 171
Cdd:cd13132 80 GVYLQRALVILLLCCVPISllwLNTEPILLLLGQDPEIARLAGEYLRWLIPGLFAYALFEPLKRYLQAQGIVLPLVYISL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 172 FSTILNILLDLFCILILDWGVAGAAVATVFSQGVSAVLCYLYMMRH--FEILKGTPTEHKFRGalAKTLLYIGVPMGLQ- 248
Cdd:cd13132 160 VALLLNILLNYLLVFVLGLGFIGAALATSISYWLIVVLLLLYIFFSkgHKATWGGFSREAFRG--WGPFLKLAIPSALMl 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 249 ------FSITAIGSIMLQsannalGTACVAAFTAAMRI-KMFCMCPLeSLGIAMATYSGQNYGAGKPKRIWLGIKASVLM 321
Cdd:cd13132 238 clewwaFEILVLLAGLLP------GTVALAAQSICLTTtSLLYMIPL-GISIAASVRVGNELGAGNPKRAKLAAIVALIL 310
|
330 340
....*....|....*....|....*...
gi 501002816 322 MVIYCGFMFVVLMLGARTFALLFVDPAE 349
Cdd:cd13132 311 SLVIGVVVAILLLVLRDVWAYLFTSDEE 338
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
16-213 |
4.30e-14 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 73.64 E-value: 4.30e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 16 ILNFAFPLLLGNLLQQTYSLMDAAIVGKFlGINALASVGASTSVVFLILGFCNGCCGGFGIPVAQKFGARDYGMMRRFVA 95
Cdd:COG0534 231 ILRIGLPAGLQQLAESLGFLVLNALVARL-GTAAVAAYGIALRIESLAFMPALGLGQAAQPLVGQNLGAGDYDRARRAAR 309
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 96 VSLQLAAVMSVVIAIVTSMFCSDILQMMQTPENILEDAYLYLLITFIGVPCTFFYNLLSSIIRALGDSKTPFWFLLFSTI 175
Cdd:COG0534 310 LALLLALGIGLLLALLLFLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIISLLRLW 389
|
170 180 190
....*....|....*....|....*....|....*...
gi 501002816 176 LNILLDLFCILILDWGVAGAAVATVFSQGVSAVLCYLY 213
Cdd:COG0534 390 LVRLPLAYLLAFLGLGLTGVWLALPIGEVLRALLLLLR 427
|
|
| PRK10367 |
PRK10367 |
DNA-damage-inducible SOS response protein; Provisional |
20-412 |
7.39e-13 |
|
DNA-damage-inducible SOS response protein; Provisional
Pssm-ID: 182413 [Multi-domain] Cd Length: 441 Bit Score: 70.15 E-value: 7.39e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 20 AFPLLLGNLLQQTYSLMDAAIVGK-----FLGINALASVgaSTSVVFLILGFCNGCCGGFgipVAQKFGARDYGMMRRFV 94
Cdd:PRK10367 15 ALPMIFSNITVPLLGLVDTAVIGHldspvYLGGVAVGAT--ATSFLFMLLLFLRMSTTGL---TAQAFGAKNPQALARAL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 95 AVSLQLAAVMSVVIAIVTSMFCSDILQMMQTPENILEDAYLYLLITFIGVPCTFFYNLLSSIIRALGDSKTPFWFLLFST 174
Cdd:PRK10367 90 VQPLLLALGAGALIALLRTPLIDLALHIVGGSEAVLEQARRFLEIRWLSAPASLANLVLLGWLLGVQYARAPVILLVVGN 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 175 ILNILLDLFCILILDWGVAGAAVATVFSQGVSaVLCYLYMMRHFEILKGTPTE---HKFRG------ALAKTLLYIGVPM 245
Cdd:PRK10367 170 ILNIVLDLWLVMGLHMNVQGAALATVIAEYAT-LLIGLLMVRKVLKLRGISLEmlkTAWRGnfrrllALNRDIMLRSLLL 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 246 GLQF-SITAIGSimlqsannALGTACVAAFTAAMRIKMFCMCPLESLGIAMATYSGQNYGAGKPKR---IWLGIKASVLM 321
Cdd:PRK10367 249 QLCFgAITVLGA--------RLGSDIIAVNAVLMTLLTFTAYALDGFAYAVEAHSGQAYGARDGSQlldVWRAACRQSGI 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 322 MVIycGFMFVVLMLGARTFALLFVDPaEWEILKDTELFLHIsvsFFPVLGLLCilrYSIQG--VGFTNLA-MLSGVSEMI 398
Cdd:PRK10367 321 VAL--LFSLVYALAGEHIIALLTSLP-QIQQLADRYLIWQV---ILPLVGVWC---YLLDGmfIGATRAAeMRNSMAVAA 391
|
410
....*....|....
gi 501002816 399 ARIMVSLYAVPILG 412
Cdd:PRK10367 392 AGFALTLLTLPWLG 405
|
|
| PRK01766 |
PRK01766 |
multidrug efflux protein; Reviewed |
20-331 |
1.52e-12 |
|
multidrug efflux protein; Reviewed
Pssm-ID: 234981 [Multi-domain] Cd Length: 456 Bit Score: 69.07 E-value: 1.52e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 20 AFPLLLGNLLQQTYSLMDAAIVGKFlGINALASVGASTSVVFLILGFCNGCCGGFGIPVAQKFGARDYGMMRRFVAVSLQ 99
Cdd:PRK01766 18 ALPILLAQVAQTAMGFVDTVMAGGV-SATDLAAVAIGTSIWLPVILFGHGLLLALTPIVAQLNGAGRRERIAHQVRQGLW 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 100 LAAVMSVVIAIVTSMFCSDILQMMQTPENILEDAYLYLLITFIGVPCTFFYNLLSSIIRALGDSKTPFWFLLFSTILNIL 179
Cdd:PRK01766 97 LALFLSVLIMLVLYNAVPPILNMMNLEPEVADIAVGYLHALLWGIPAYLLYQVLRSFIDGLGKTKPTMVIGFLGLLINIP 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 180 LDLfcILIL------DWGVAGAAVAT--VFSQGVSAVLCYLYMMRHFEILKGTPTEHKFRGALAKTLLYIGVPMGLQF-- 249
Cdd:PRK01766 177 LNY--IFIYgkfgfpELGGVGCGVATaiVYWVMFLAMLIYIKRARRFRDFRLFKGLYKPDWAVIKRLLKLGLPIGLAIff 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 250 --SITAIGSIMLqsanNALGTACVAAFTAAMRIKMFC-MCPLeSLGIAMATYSGQNYGAGKPKRI----WLGIKASVLMM 322
Cdd:PRK01766 255 evSLFAVVTLLV----SPLGTVTVAAHQIALNFSSLLfMLPL-SLAMALTIRVGFELGAGRTLDArqyaYIGLAVGLGMA 329
|
....*....
gi 501002816 323 VIYCGFMFV 331
Cdd:PRK01766 330 LLTAIFLVL 338
|
|
| RfbX |
COG2244 |
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane ... |
15-211 |
5.68e-12 |
|
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441845 [Multi-domain] Cd Length: 366 Bit Score: 66.90 E-value: 5.68e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 15 LILNFAFPLLLGNLLQQTYSLMDAAIVGKFLGINALASVGASTSVVFLILGFCNGCCGGFGIPVAQKFGARDYGMMRRFV 94
Cdd:COG2244 174 LVLKYSLPLLLSGLLGLLLTNLDRLLLGALLGPAAVGIYSAAYRLASLLLLLITALSQVLFPRLSRLLAEGDREELRRLY 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 95 AVSLQLAAVMSVVIAIVTSMFCSDILQMMQTPEniLEDAYLYLLITFIGVPCTFFYNLLSSIIRALGDSKTPFWFLLFST 174
Cdd:COG2244 254 RKALRLLLLLGLPLALGLALLAPPLLSLLFGPE--YAEAAPVLPILALGALFLALSGVLSNLLLALGRTRLLLIISLIGA 331
|
170 180 190
....*....|....*....|....*....|....*..
gi 501002816 175 ILNILLDLfcILILDWGVAGAAVATVFSQGVSAVLCY 211
Cdd:COG2244 332 VLNLVLNL--LLIPRYGLVGAAIATLLSYLVLLLLLL 366
|
|
| MATE_Wzx_like |
cd13128 |
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
16-214 |
8.45e-12 |
|
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240533 [Multi-domain] Cd Length: 402 Bit Score: 66.41 E-value: 8.45e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 16 ILNFAFPLLLGNLLQQTYSLMDAAIVGKFLGINALASVGASTSVVFLILGFCNGCCGGFgIPVAQKFGARDYGMMRRFVA 95
Cdd:cd13128 208 LLRFSIPLALSGIFSLIYTRIDTIMLGYFLGDAAVGIYNAAYRIAELLLFIPSAISTAL-FPRISELYKNDKDELKKLLK 286
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 96 VSLQLAAVMSVVIAIVTSMFCSDILQMMQTPENIleDAYLYLLITFIGVPCTFFYNLLSSIIRALGDSKTPFWFLLFSTI 175
Cdd:cd13128 287 KSFKYLFLISLPIAIGLFLFAEPIITLLFGEEYL--PAALVLQILAWGFLFIFLNGIFGSILQAIGKQKLTLKILLIGAL 364
|
170 180 190
....*....|....*....|....*....|....*....
gi 501002816 176 LNILLDLfcILILDWGVAGAAVATVFSQGVSAVLCYLYM 214
Cdd:cd13128 365 LNVILNL--LLIPKYGIIGAAIATLISEFIIFILLLYLL 401
|
|
| vmrA |
PRK09575 |
MATE family efflux transporter; |
19-334 |
6.52e-10 |
|
MATE family efflux transporter;
Pssm-ID: 236576 [Multi-domain] Cd Length: 453 Bit Score: 60.78 E-value: 6.52e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 19 FAFPLLLGNLLQQTYSLMDAAIVGKFLGINALASVGASTSVVFLILGFCNGCCGGFGIPVAQKFGARDYGMMRRFVAVSL 98
Cdd:PRK09575 17 YTIPSIAAMLVNGLYQIVDGIFIGHYVGAEGLAGINMAWPVIGIILGIGLMVGMGTGSLLSIKRGEGDLEKAKRILTTGL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 99 QLAAVMSVVIAIVTSMFCSDILQMMQTPENILEDAYLYLLITFIGVPCTFFYNLLSSIIRALGDSKTPFWFLLFSTILNI 178
Cdd:PRK09575 97 LLLLLLGPIVSVILFLFADDFLRAQGAEGRTLELALQYIQVLIWGCLFTLGAIALPFLLRNDESPNLATGLMVIGALINI 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 179 LLDLFCILILDWGVAGAAVATVFSQGVSAVLCYLYMMRHFEILKGTPTEHKFRGALAKTLLYIGVPmglQFSITAIGSIM 258
Cdd:PRK09575 177 VLDYLFIGWLDWGLTGAAIATALAQLVVTVLGLGYFFSSRANIRLTLKELRFNWSLAPKIVLLGSS---SFFMYLYGSFV 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 259 LqSANNAL----GTAC-VAAFTAAMRIKMFCMCPLESLGIAMATYSGQNYGAGKPKRIWLGIKASVLMMVIyCGFMFVVL 333
Cdd:PRK09575 254 V-ALHNRLfmeyGSALtVGAYAIVGYLMVLYYLVAEGIAEGMQPPVSYYFGARQYDNIKKLLKLAMKVTVL-AGIAWVLL 331
|
.
gi 501002816 334 M 334
Cdd:PRK09575 332 L 332
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
16-217 |
1.34e-09 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 59.83 E-value: 1.34e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 16 ILNFAFPLLLGNLLQQTYSLMDAAIVGKFlGINALASVGASTSVVFLILGFCNGCCGGFGIPVAQKFGARDYGMMRRFVA 95
Cdd:cd13137 228 LLRIGLPAGLEQLLRSLGFLVLLAIVASY-GTAALAAYQIGLRIESLAFMPGFGFSMAASTLVGQNLGAGDPDEARRYGK 306
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 96 VSLQLAAVMSVVIAIVTSMFCSDILQMMQTPENILEDAYLYLLITFIGVPCTFFYNLLSSIIRALGDSKTPFWFLLFSTI 175
Cdd:cd13137 307 RALRLGVLFMGLLGLLLFIFAPPLASLFTPDPEVIELGVLYLRIVALSQPFLAISFVLSGALRGAGDTRPPLIINLISMW 386
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 501002816 176 LN-ILLDLFCILILDWGVAGAAVATVFSQGVSAVLCYLYMMRH 217
Cdd:cd13137 387 LVrLPLAYLLGFVLGLGLTGIWLAMFVDTIVRAILLLYRFRKG 429
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
247-404 |
2.93e-09 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 55.65 E-value: 2.93e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 247 LQFSITAIGSIMLQSannaLGTACVAAFTAAMRIKMFCMCPLESLGIAMATYSGQNYGAGKPKRIWLGIKASVLMMVIYC 326
Cdd:pfam01554 8 LQSLYSLIDTLFVGH----LGAVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILGLLLS 83
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 501002816 327 GFMFVVLMLGARTFALLFVDPAewEILKDTELFLHISVSFFPVLGLLCILRYSIQGVGFTNLAMLSGVSEMIARIMVS 404
Cdd:pfam01554 84 LPIALLVLLFSEPILSLFGQDE--EVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISLLLNIPLN 159
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
16-213 |
8.67e-09 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 57.33 E-value: 8.67e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 16 ILNFAFPLLLGNLLQQTYSLMDAAIVGKFLGINALASVGASTSVVFLILGFCNGCCGGFGIPVAQKFGARDYGMMRRFVA 95
Cdd:cd12082 221 LLRIGLPSAIQNSLLSLGLLIIVAIVAAFGGAAALAAYTVAFRIASLAFMPALGLAQAALPVVGQNLGAGNFDRARRITW 300
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 96 VSLQLAAVMSVVIAIVTSMFCSDILQMMQTPENILEDAYLYLLITFIGVPCTFFYNLLSSIIRALGDSKTPFWFLLFSTI 175
Cdd:cd12082 301 VALLIGLLIGAVLGLLILLFPEPILSLFTNDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSLIVSLLSYW 380
|
170 180 190
....*....|....*....|....*....|....*...
gi 501002816 176 LNILLDLFCILILDWGVAGAAVATVFSQGVSAVLCYLY 213
Cdd:cd12082 381 VVRLPLAYVLAYLGLGLYGIWLALVISLILAALVLLLF 418
|
|
| MATE_SpoVB_like |
cd13124 |
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related ... |
78-220 |
4.96e-08 |
|
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; The integral membrane protein SpoVB has been implicated in the biosynthesis of the peptidoglycan component of the spore cortex in Bacillus subtilis. This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240529 [Multi-domain] Cd Length: 434 Bit Score: 54.78 E-value: 4.96e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 78 VAQKFGARDYGMMRRFVAVSLQLAAVMSVVIAIVTSMFCSDILQMMQTPEnileDAYLYLLITFIGVPCTFFYNLLSSII 157
Cdd:cd13124 298 ISEAYAKGDKKELRRRINQALRLTLLIGLPAAVGLAVLAEPINTLLFGDS----EGGLILQILAPSILFLSLQQVTAAIL 373
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 501002816 158 RALGDSKTPFWFLLFSTILNILLDLFCILIldWGVAGAAVATVFSQGVSAVLCYLYMMRHFEI 220
Cdd:cd13124 374 QGLGKVKIPVINLLIGLLVKIVLNYVLIPI--FGIYGAAIATVIGFLVAALLNLRALKKLLGF 434
|
|
| PRK10189 |
PRK10189 |
EmmdR/YeeO family multidrug/toxin efflux MATE transporter; |
16-307 |
6.75e-07 |
|
EmmdR/YeeO family multidrug/toxin efflux MATE transporter;
Pssm-ID: 182293 [Multi-domain] Cd Length: 478 Bit Score: 51.27 E-value: 6.75e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 16 ILNFAFPLLLGNLLQQTYSLMDAAIVgKFLGINALASVGASTSVVFLILGFCNGCCGGFGIPVAQKFGARDYGMMRRFVA 95
Cdd:PRK10189 31 ITPLAVPIFIENLCVLLMGVLSTFLV-SWLGKEAMAGVGLADSFNMVIMAFFAAIDLGTTVVVAFSLGKRDRRRARAAAR 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 96 VSLQLAAVMSVVIAIVTSMFCSDILQMM--QTPENILEDAYLYLLITFIGVPCTFFYNLLSSIIRALGDSKTPFWFLLFS 173
Cdd:PRK10189 110 QSLVIMTLFAVLLAVLIHFFGEQIIDLVagDATPEVKALALTYLELTVWSYPAAAITLIGSGALRGAGNTKIPLLINGGM 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 174 TILNILLDLFCIL-ILDW---GVAGAAVATVFSQGVSAVLCYLYMMRHFEILKGTPTEHKFR---GALAKTLLYIGVPMG 246
Cdd:PRK10189 190 NILNIIISSILIYgLFSWqglGFVGAGLGLTISRYIGAVAIIWVLMIGFNPALRISLKSYFKplnFAIIWEVMGIGIPAS 269
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 501002816 247 LQFSITAIGSIMLQSANNALGTACVAAFTAAMRIKMFCMCPLESLGIAMATYSGQNYGAGK 307
Cdd:PRK10189 270 IESVLFNGGKLLTQMFVAGMGTSVIAGNFIAFSIAALINLPGNALGSASTIITGTRLGKGQ 330
|
|
| PRK00187 |
PRK00187 |
NorM family multidrug efflux MATE transporter; |
16-307 |
7.90e-07 |
|
NorM family multidrug efflux MATE transporter;
Pssm-ID: 166843 [Multi-domain] Cd Length: 464 Bit Score: 51.28 E-value: 7.90e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 16 ILNFAFPLLLGNLLQQTYSLMDAAIVGKfLGINALASVGASTSVVFLILGFCNGCCGGFGIPVAQKFGARDYGMMRRFVA 95
Cdd:PRK00187 12 ILRLAGPLIASQLAHMLMVFTDTLMMGR-LGPEALAGGGLGAASYSFVSIFCVGVIAAVGTLVAIRHGAGDIEGATRLAQ 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 96 VSLQLAAVMSVVIAIVTSMFCSDILQMMQTPENIlEDAYLYLLITFIGVPCTFFYNLLSSIIRALGDSKTPFWFLLFSTI 175
Cdd:PRK00187 91 AGLWLAWLLALVAALLLWNLKPLLLLFGQAPQNV-DAAMQFLHLLPFALPGYLSFMALRGFTSALGRAGPVMVISLAGAV 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 176 LNILLDLfcILILDW------GVAGAAVATVFSQGVSAVLCYLYMMRH-----FEILKGTpteHKFRGALAKTLLYIGVP 244
Cdd:PRK00187 170 ANLLLNY--ALIEGWfglpklGLMGIGLVTALVSNGMALALALYIRRHpayaaYPLRKGL---SRPSRAALRELWRLGLP 244
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 501002816 245 MGLQFSIT----AIGSIMLqsanNALGTACVAAFTAAMRI-KMFCMCPLeSLGIAMATYSGQNYGAGK 307
Cdd:PRK00187 245 IGGTYAVEvglfTFAALCM----GALGSTQLAAHQIALQIvSVAFMVPV-GLSYAVTMRVGQHYGAGR 307
|
|
| MATE_Wzx_like |
cd13128 |
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
73-439 |
9.29e-07 |
|
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240533 [Multi-domain] Cd Length: 402 Bit Score: 51.00 E-value: 9.29e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 73 GFGIPVA-QKFGARDYGMMRR-FVAVSLQLAAVMSVVIAIVtsmfcsdILQMMQTPENILEDAYLYLLITFIGVPCTFFY 150
Cdd:cd13128 53 DLGLPTAlVREIARYRKEKIReIISTSLVLKLILGILALLL-------LFLFAFLIAFYDPELVLLLYILALSLPFSALN 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 151 NLLSSIIRALGDSKTPFWFLLFSTILNILLdLFCILILDWGVAGAAVATVFSQGVSAVLCYLYMMRHFEILKgtptEHKF 230
Cdd:cd13128 126 SLFRGIFQGFEKMKYIVIARIIESVLSLIL-ALILVLLGGGLIGFALAYLIASVLSAILLLYIYRKKILLPK----FFSF 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 231 RGALAKTLLYIGVPMGL----QFSITAIGSIMLQsanNALGTACVAAFTAAMRIKMFCMCPLESLGIAMATYSGQNYGAG 306
Cdd:cd13128 201 DLKLAKELLRFSIPLALsgifSLIYTRIDTIMLG---YFLGDAAVGIYNAAYRIAELLLFIPSAISTALFPRISELYKND 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 307 KpKRIWLGIKASVLMMVIYCGFMFVVLMLGARTFALLFVDPaewEILKDTELFLHISVSFFpVLGLLCILRYSIQGVGFT 386
Cdd:cd13128 278 K-DELKKLLKKSFKYLFLISLPIAIGLFLFAEPIITLLFGE---EYLPAALVLQILAWGFL-FIFLNGIFGSILQAIGKQ 352
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 501002816 387 NLAMLSGVSEMIARIMVSLYAVPILGYlavcFGDPTAWIFAVIFLIPAFIYVY 439
Cdd:cd13128 353 KLTLKILLIGALLNVILNLLLIPKYGI----IGAAIATLISEFIIFILLLYLL 401
|
|
| MATE_MurJ_like |
cd13123 |
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
142-217 |
4.28e-05 |
|
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli MurJ (MviN) has been identified as essential for murein biosynthesis. It has been suggested that MurJ functions as the peptidoglycan lipid II flippase which is involved in translocation of lipid-anchored peptidoglycan precursors across the cytoplasmic membrane, though results obtained in Bacillus subtilis seem to indicate that its MurJ homologs are not essential for growth. Some MviN family members (e.g. in Mycobacterium tuberculosis) possess an extended C-terminal region that contains an intracellular pseudo-kinase domain and an extracellular domain resembling carbohydrate-binding proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240528 [Multi-domain] Cd Length: 420 Bit Score: 45.52 E-value: 4.28e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 501002816 142 IGVPCTFFYNLLSSIIRALGDSKTPFWFLLFSTILNILLDLfcILILDWGVAGAAVATVFSQGVSAVLCYLYMMRH 217
Cdd:cd13123 347 LGLPAFALVKLLSRAFYALKDTKTPVKIAVIAVAVNILLNL--LLIKPLGHVGLALATSLSAWVNALLLLVLLRRR 420
|
|
| MurJ |
COG0728 |
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope ... |
142-218 |
7.64e-05 |
|
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440492 [Multi-domain] Cd Length: 503 Bit Score: 45.14 E-value: 7.64e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 501002816 142 IGVPCTFFYNLLSSIIRALGDSKTPFWFLLFSTILNILLDLfcILILDWGVAGAAVATVFSQGVSAVLCYLYMMRHF 218
Cdd:COG0728 354 LGLPAFALVKVLARAFYARQDTRTPVRIAVIAVVVNIVLNL--LLVPPLGHAGLALATSLSALVNALLLLVLLRRRL 428
|
|
| Polysacc_synt_C |
pfam14667 |
Polysaccharide biosynthesis C-terminal domain; This family represents the C-terminal integral ... |
136-220 |
8.01e-05 |
|
Polysaccharide biosynthesis C-terminal domain; This family represents the C-terminal integral membrane region of polysaccharide biosynthesis proteins.
Pssm-ID: 434111 [Multi-domain] Cd Length: 141 Bit Score: 42.56 E-value: 8.01e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 136 YLLITFIGVPCTFFYNLLSSIIRALGDSKTPFWFLLFSTILNILLDLfcILILDWGVAGAAVATVFSQGVSAVLCYLYMM 215
Cdd:pfam14667 1 VLQILALSIIFLSLSTVLTSILQGLGRTKLALIALLIGALVKLILNL--LLIPLFGIVGAAIATVISLLVVALLNLYYLR 78
|
....*
gi 501002816 216 RHFEI 220
Cdd:pfam14667 79 RYLGL 83
|
|
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
15-190 |
8.58e-05 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 44.76 E-value: 8.58e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 15 LILNFAFPLLLGNLLQQTYSLMDAAIVGKFlGINALASVGASTSVVFLILGFCNGCCGGFGIPVAQKFGARDYGMMRRFV 94
Cdd:cd13138 226 EILKIGLPSALQQSLVSISFLIINSIVNSY-GVVASAAYGIANKINSFAFLPPSAIGQAVSTFVAQNIGAGKIERAKKGL 304
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 95 AVSLQLAAVMSVVIAIVTSMFCSDILQMMQTPENILEDAYLYLLITFIGVPCTFFYNLLSSIIRALGDSKTPF------- 167
Cdd:cd13138 305 RTGIIISLIIGLIIILLVFFFAPQLLGLFTSDPEVIEIGAEYLRIYSIDYILFGILFVFNGLFRGLGKTKFPMiisilrl 384
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 501002816 168 --------WFL---------------LFSTILNILLDLFCILILDW 190
Cdd:cd13138 385 wlvriplaYLLsrltglglfgiwlamPISNILSAIICIIYYRKGRW 430
|
|
| MATE_like_9 |
cd13135 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
78-213 |
2.59e-04 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240540 [Multi-domain] Cd Length: 429 Bit Score: 43.05 E-value: 2.59e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 78 VAQKFGARDYGMMRRFVAVSLQLAAVMSVVIAIVTSMFCSDILQMMQTPENILEDAYLYLLITFIGVPCTFFYNLLSSII 157
Cdd:cd13135 291 VGESIGKKDLKEALRIGNICLGLGLLIYIAAAIVFLAFPYKILSLFTNDPELINYSIPYLIFIIIILFFKSINIVYGFAI 370
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 501002816 158 RALGDSKTPFWFLLFSTILNILLDLFCILILDWGVAGAAVATVFSQGVSAVLCYLY 213
Cdd:cd13135 371 RAIGDTKWMLYTQIIGTIIVVSVALLLIFVFKLGLAGVYITLFIDEIIRAIINFLK 426
|
|
| MATE_tuaB_like |
cd13127 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This ... |
9-220 |
1.51e-03 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This family might function as a translocase for lipopolysaccharides and participate in the biosynthesis of cell wall components such as teichuronic acid. The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240532 [Multi-domain] Cd Length: 406 Bit Score: 40.55 E-value: 1.51e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 9 SGRPFPLILNFAFPLLLGNLLQQTYSLMDAAIVGKFLGINALASVGASTSVVFLILGFCNGCCGGFGIPVAQKFgARDYG 88
Cdd:cd13127 194 SLASLKELLSFGSKLLGSNLLNYFSRNLDNLIIGKFLGAAALGYYSRAYRLALLPVQNITGPITRVLFPALSRL-QDDPE 272
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 89 MMRRFVAVSLQLAAVMSVVIAIVTSMFCSDILQMMQTPEniLEDAYLYLLITFIGVPCTFFYNLLSSIIRALGDSKTPFW 168
Cdd:cd13127 273 RLRRAYLKALRLLALITFPLMVGLALLAEPLVLLLLGEK--WLPAVPILQILALAGLFQPLSSLNGSLLLALGRTDLLLK 350
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 501002816 169 FLLFSTILNILLdlfCILILDWGVAGAAVATVFSQGVSAVLCYLYMMRHFEI 220
Cdd:cd13127 351 LGLIKAVLTVLA---LLIGIPYGIIGVAIAYVIASLLSFPLNLYLAGRLIGI 399
|
|
| murJ_mviN |
TIGR01695 |
murein biosynthesis integral membrane protein MurJ; This model represents MurJ (previously ... |
78-257 |
1.86e-03 |
|
murein biosynthesis integral membrane protein MurJ; This model represents MurJ (previously MviN), a family of integral membrane proteins predicted to have ten or more transmembrane regions. Members have been suggested to act as a lipid II flippase, translocated a precursor of murein. However, it appears FtsW has that activity. Flippase activity for MurJ has not been shown. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273763 [Multi-domain] Cd Length: 502 Bit Score: 40.38 E-value: 1.86e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 78 VAQKFGARDYGMMRRFVAVSLQLAAVMSVVIAIVTSMFCSDILQMMQ-----TPENILEDAYLyLLITFIGVPCTFFYNL 152
Cdd:TIGR01695 287 LSRHASEGNWNELRDLLNQGIRLSLLLTIPSSFGLLILSIPIVSLLFergafSEEDTVMTATI-LAAYGLGLIFYSLQKV 365
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90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501002816 153 LSSIIRALGDSKTPFWFLLFSTILNILLDLFciLILDWGVAGAAVATVFSQGVSAVLCYLYMMRHFEILKGTPTEhKFRG 232
Cdd:TIGR01695 366 LLRAFYARKDTRTPFINSVISVVLNALLSLL--LIFPLGLVGIALATSAASMVSSVLLYLMLNRRLKGILPFGVL-KVLA 442
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170 180
....*....|....*....|....*
gi 501002816 233 ALAKTLLYIGVPMGLQFSITAIGSI 257
Cdd:TIGR01695 443 KLVIASAIIGGVLYLIVSVSLGGVL 467
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| MurJ |
pfam03023 |
Lipid II flippase MurJ; Peptidoglycan synthesis (PG) biosynthesis involves the formation of ... |
151-223 |
8.86e-03 |
|
Lipid II flippase MurJ; Peptidoglycan synthesis (PG) biosynthesis involves the formation of peptidoglycan precursor lipid II (undecaprenyl-pyrophosphate-linked N-acetyl glucosamine-N-acetyl muramic acid-pentapeptide) on the cytosolic face of the cell membrane. Lipid II is then translocated across the membrane and its glycopeptide moiety becomes incorporated into the growing cell wall mesh. MviN, renamed as MurJ, is a lipid II flippase essential for cell wall peptidoglycan synthesis. MurJ belongs to the MVF (mouse virulence factor) family of MOP superfamily transporters, which also includes the MATE (multidrug and toxic compound extrusion) transporter and eukaryotic OLF (oligosaccharidyl-lipid flippase) families. In addition to the canonical MOP transporter core consisting of 12 transmembrane helices (TMs), MurJ has two additional C-terminal TMs (13 and 14) of unknown function. Structural analysis indicates that the N lobe (TMs 1-6) and C lobe (TMs 7-14) are arranged in an inward-facing N-shape conformation, rather than the outward-facing V-shape conformation observed in all existing MATE transporter structures. Furthermore, a hydrophobic groove is formed by two C-terminal transmembrane helices, which leads into a large central cavity that is mostly cationic. Mutagenesis studies, revealed a solvent-exposed cavity that is essential for function. Mutation of conserved residues (Ser17, Arg18, Arg24, Arg52, and Arg255) at the proximal site failed to complement MurJ function, consistent with the idea that these residues are important for recognizing the diphosphate and/or sugar moieties of lipid II. It has also been suggested that the chloride ion in the central cavity and a zinc ion at the beginning of TM 7 might be functionally important.
Pssm-ID: 397249 [Multi-domain] Cd Length: 451 Bit Score: 38.43 E-value: 8.86e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 501002816 151 NLLSSIIRALGDSKTPFWFLLFSTILNILLDLfcILILDWGVAGAAVATVFSQGVSAVLCYLYMMRHFEILKG 223
Cdd:pfam03023 338 KLLSRVFYAREDTKTPFKISLISAVLNILLSL--LLLPPLGVAGLALATSLSSLIGLVFLYYILRKRLGGFDL 408
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