|
Name |
Accession |
Description |
Interval |
E-value |
| PTR2 |
COG3104 |
Dipeptide/tripeptide permease [Amino acid transport and metabolism]; |
5-440 |
1.24e-106 |
|
Dipeptide/tripeptide permease [Amino acid transport and metabolism];
Pssm-ID: 442338 [Multi-domain] Cd Length: 479 Bit Score: 324.46 E-value: 1.24e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 5 KKMPTGFYFCSLAFTFERFAFYSAKWLITMFVAAKIINGGLGLTPADGAKMSANLVAWTYFAPLIGSYISDRKIGARYLV 84
Cdd:COG3104 10 FGHPKGLYTLFFTEMWERFSFYGMRAILVLYLTASLADGGLGLSEADAAAIYGAYTALVYLTPLLGGWLADRLLGQRRAI 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 85 PIGLIIMGVGYLVGWKASSAGMINLMIILISIGTGLFKAQVNAITGRLF-NDQKQLDSAFSIQYSYVNIGSFIGTTTIGV 163
Cdd:COG3104 90 LLGGILMALGHFLLALPGGVTLFYLGLALIAVGNGLFKPNISSLVGQLYdPGDPRRDAGFTIFYMGINIGAFLAPLLCGY 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 164 LAGSMGYSFCFLICAIMTFIYAVIFIFGWRFLGDTGKKPFKIDEHKEVKEAK---------------------------- 215
Cdd:COG3104 170 LGEKYGWHYGFGAAAIGMLIGLIIFLLGRKYLGDIGLEPDNPLSKKERLIAValgalllvlvlagllsnanianyllyvi 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 216 --------QEEKKPLTKIEKKRIGAIILISFFSIIFWIFWQLAYLPVYFYWggdNGFANWMIGNFKVPTVWFDSLNALCC 287
Cdd:COG3104 250 aiiayfifILRSKKLTKEERKRLLAILILFLFSIVFWALYEQAGTSLNLFA---DRNVDRSLFGFEIPPSWFQSLNPLFI 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 288 IVLGPILARVWAKLARRpQGDMSMFKKTALGMLLLGLSYVIFAMADVTRG-NNLLPLAWLVVFGIILSLSEMVFSPLGNS 366
Cdd:COG3104 327 IILAPVFAALWTKLGKR-GKEPSTPTKFALGLLLLGLGFLVMALAALLAGaGGKVSPLWLVLAYLLLTIGELCLSPVGLS 405
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 501048328 367 FISKFSPAKMLTAMMSVWVLATFFAGKSFGYVYEFTLKFKFAPTYFVIAAIAIVCGIILWALDGKLNSLVVDEE 440
Cdd:COG3104 406 MITKLAPARFAGQMMGLWFLATALGNLLAGLLAGLYAVPGYTAYFLLLGGIALVAGVVLLLLSPKLRRLMHGVE 479
|
|
| MFS_DtpA_like |
cd17346 |
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily ... |
8-431 |
1.36e-91 |
|
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily of transporters; The DtpA-like subfamily includes four Escherichia coli proteins: dipeptide and tripeptide permeases A (DtpA, TppB or YdgR), B (DtpB or YhiP), C (DtpC or YjdL), and D (DtpD or YbgH). They are proton-dependent permeases that transport di- and tripeptides. DtpA and DtpB display a preference for di- and tripeptides composed of L-amino acids. DtpC shows higher specificity for dipeptides compared to tripeptides, and prefers dipeptides containing a C-terminal lysine residue. The DtpA-like subfamily belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340904 [Multi-domain] Cd Length: 399 Bit Score: 282.93 E-value: 1.36e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 8 PTGFYFCSLAFTFERFAFYSAKWLITMFVAAKIingGLGLTPADGAKMSANLVAWTYFAPLIGSYISDRKIGARYLVPIG 87
Cdd:cd17346 1 PKGLYTLFFTEMWERFSYYGMRAILILYLTAQL---GDGFSEADAASIYGAYTALVYLTPIIGGWLADKVLGARRTVFIG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 88 LIIMGVGYLV-GWKASSAGMINLMIILISIGTGLFKAQVNAITGRLFN-DQKQLDSAFSIQYSYVNIGSFIGTTTIGVLA 165
Cdd:cd17346 78 GILMALGYLLlALSPFSVSMLYLGLALIIVGNGLFKPNISSLVGKLYDeNDPRRDSGFSIFYMGINLGAFLAPLLCGTLG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 166 GSMGYSFCFLICAIMTFIYAVIFIFGWRFLGdtgkkpfkidehkevkeakqeekkpltkiEKKRIGAIILISFFSIIFWI 245
Cdd:cd17346 158 DNYGYHYGFGLAAVGMLLGLLIFLLGRKKLL-----------------------------ERKKMLAIIILFLFAVVFWA 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 246 FWQLAYLPVYFYWggdNGFANWMIGNFKVPTVWFDSLNALCCIVLGPILARVWAKLARRpQGDMSMFKKTALGMLLLGLS 325
Cdd:cd17346 209 IYEQAGTSLALFA---DENVDRLLGGFTIPPSWFQSLNPLFIILLAPILAALWTKLGKR-GKDPSIPTKFALGLLLLGLS 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 326 YVIFAMADVTRGNN-LLPLAWLVVFGIILSLSEMVFSPLGNSFISKFSPAKMLTAMMSVWVLATFFAGKSFGYVYEFTL- 403
Cdd:cd17346 285 FLLMVLAASFAGGSgKVSALWLVLSYFLQTLGELCLSPVGLSMITKLAPAKFAGFMMGLWFLASALGNILAGYLAGFYAq 364
|
410 420 430
....*....|....*....|....*....|....*
gi 501048328 404 -------KFKFAPTYFVIAAIAIVCGIILWALDGK 431
Cdd:cd17346 365 pkdplasALVYTDYFGLIGVIALVAGIILLLLAKK 399
|
|
| yjdL_sub1_fam |
TIGR00924 |
amino acid/peptide transporter (Peptide:H+ symporter), bacterial; The model describes ... |
8-436 |
3.66e-38 |
|
amino acid/peptide transporter (Peptide:H+ symporter), bacterial; The model describes proton-dependent oligopeptide transporters in bacteria. This model is restricted in its range in recognizing bacterial proton-dependent oligopeptide transporters, although they are found in yeast, plants and animals. They function by proton symport in a 1:1 stoichiometry, which is variable in different species. All of them are predicted to contain 12 transmembrane domains, for which limited experimental evidence exists. [Transport and binding proteins, Amino acids, peptides and amines]
Pssm-ID: 273342 [Multi-domain] Cd Length: 475 Bit Score: 144.59 E-value: 3.66e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 8 PTGFYFCSLAFTFERFAFYSAKWLITMFVAAKiinGGLGLTPADGAKMSANLVAWTYFAPLIGSYISDRKIGARYLVPIG 87
Cdd:TIGR00924 9 PKPLFTLFFVELWERFSYYGMQGILAVYLVQQ---AGLGFSQEQAFIIFGAYSALVYLLTSVGWWFGDRVWGTKKTMVLG 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 88 LIIMGVGYLVGWKASSAGMINLMIILISIGTGLFKAQVNAITGRLFN--DQKQLDSAFSIQYSYVNIGSFIGTTTIGVLA 165
Cdd:TIGR00924 86 GIVLMLGHFMLAMSIYPDLIFYGLGTIAVGSGLFKANPSSMVGKLYErgDMPRRDGGFTLFYMSINIGSFISPLLAGVIA 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 166 GSMGYSFCFLICAIMTFIYAVIFIFGWRFLGDTGKKPFKIDEHKEVKEA------------------------------- 214
Cdd:TIGR00924 166 ENYGYHVGFNLAAVGMVIGLLTFFAGRHMLRDIGSVPDPLSGQGKTYGKlllallaalalvffcawlmhhvvianillmt 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 215 ----------KQEEKKPLTKIEKKRIGAIILISFFSIIFWIFWQLAYLPVYFYwgGDNGfANWMIGNFKVPTVWFDSLNA 284
Cdd:TIGR00924 246 vtlaviifffRLAFKPRLDAVARNKMYAYIVLFLEAVVFWVLYAQMPTSLNFF--ADNN-MHHEMLGMSVPVIWFQSLNP 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 285 LCCIVLGPILARVWAKLARRPQgDMSMFKKTALGMLLLGLSYVIF-AMADVTRGNNLLPLAWLVVFGIILSLSEMVFSPL 363
Cdd:TIGR00924 323 FWVVVGSPVLAMIWTRLGRKGK-DPTTPLKFTLGMLFCGASFLTFaASIWFADAGGLTSPWFMVLIYLFQTLGELMISPL 401
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 501048328 364 GNSFISKFSPAKMLTAMMSVWVLATFFAGKSFGYVYEFTLKFKFAPTYF-VIAAIAIVCGIILWALDGKLNSLV 436
Cdd:TIGR00924 402 GLSWWTKIAPQRLMGQMLGMWFLAQAMGSLLGGYLATFGAVPQGVTGVFgKIGLVTLLVGVVMALMVPWLNRMM 475
|
|
| PTR2 |
pfam00854 |
POT family; The POT (proton-dependent oligopeptide transport) family all appear to be proton ... |
86-414 |
1.40e-24 |
|
POT family; The POT (proton-dependent oligopeptide transport) family all appear to be proton dependent transporters.
Pssm-ID: 425909 [Multi-domain] Cd Length: 392 Bit Score: 104.71 E-value: 1.40e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 86 IGLIIMGVGYLV-GWKASSAGMINLM-------IILISIGTGLFKAQVNAITGRLF--NDQKQLDSAFSIQYSYVNIGSF 155
Cdd:pfam00854 6 LGSIIYAIGHILlALSAIPSLRPPVHvalffigLALIALGTGGIKPNVSSFGGDQFeeTDPRRRSRFFSIFYFSINAGSL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 156 IGTTTIGVLAGSMGYSFCFLICAIMTFIYAVIFIFGWRFLGDTGKKP---------------FKIDEHKEVKEAKQEEKK 220
Cdd:pfam00854 86 ISTIITPYLQQNYGYPLGFGLPAVGMIIALLVFLLGSRMYKKKPPKGnvltkvfkvlpvaawNKVKLNGSSAGIKKLHWL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 221 PLTKIEKKRIGAIILISFFSIIFWIFWQ--------LAYLPVYF----YW-----GGD--NGFANWM---IGNFKVPTVW 278
Cdd:pfam00854 166 DWARELDALIILGIVVPGIFFNIWCTKTkveevkrlLRVLPLFLplimFWalydqMGTswVLQARTMnrkIGSFEIPPAQ 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 279 FDSLNALCCIVLGPILARVWAKLARRPQGDMSMFKKTALGMLLLGLSYVIFAMADVTR----------GNNLLPLAWLVV 348
Cdd:pfam00854 246 FQAFNAILVLIFIPIFDRLVYPLGRKCTGGLTPLQKMAVGLFLASLAFAIAAIVQLKRndtgpefpiaQEVPISVLWLIP 325
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 501048328 349 FGIILSLSEMVFSPLGNSFISKFSPAKMLTAMMSVWVLATFFAGKSFGYVYEFTLKFKF-APTYFVI 414
Cdd:pfam00854 326 QYLLIGFGELFISIGGLEFFYKLAPKSMTSLITGLFLLTNALGNFLSGVIATLTAKPTNvLGAYGWL 392
|
|
| tppB |
PRK09584 |
dipeptide/tripeptide permease DtpA; |
3-398 |
3.01e-21 |
|
dipeptide/tripeptide permease DtpA;
Pssm-ID: 181969 Cd Length: 500 Bit Score: 95.98 E-value: 3.01e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 3 NTKKMPTGFYFCSLAFTFERFAFYSAKWLITMFVAAKiinggLGLTPADGAKMSANLVAWTYFAPLIGSYISDRKIGARY 82
Cdd:PRK09584 15 NAFKQPKAFYLIFSIELWERFGYYGLQGIMAVYLVKQ-----LGMSEADSITLFSSFSALVYGLVAIGGWLGDKVLGTKR 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 83 LVPIGLIIMGVGY-LVGWKASSAGMINLMIILISIGTGLFKAQVNAITGRLFN-DQKQLDSAFSIQYSYVNIGSFIGTTT 160
Cdd:PRK09584 90 VIMLGAIVLAIGYaLVAWSGHDAGIVYMGMATIAVGNGLFKANPSSLLSTCYEkDDPRLDGAFTMYYMSINIGSFFSMLA 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 161 IGVLAGSMGYSFCFLICAIMTFIYAVIFIFGWRFLGDTGKKPFKIDEHKEVKEAKQEEKKPLTKI-----EKKRIGAIIL 235
Cdd:PRK09584 170 TPWLAAKYGWSVAFALSVVGMLITVVNFAFCQRWVKQYGSKPDFEPINYRKLLLTIVGVVALIAIatwllHNQEIARMAL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 236 ISFFSIIFWIFWQLAYL-------------------PVYFYWGGD-----NGFA----NWMIGNFKVPTVWFDSLNALCC 287
Cdd:PRK09584 250 GVVALGIVVIFGKEAFAmkgaarrkmivafilmleaIIFFVLYSQmptslNFFAirnvEHSILGIAVEPEQYQALNPFWI 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 288 IVLGPILARVWAKLARRpqgdMSMFKKTALGMLLLGLSYVIFAM-ADVTRGNNLLPLAWLVVFGIILSLSEMVFSPLGNS 366
Cdd:PRK09584 330 MIGSPILAAIYNKMGDR----LPMPHKFAIGMVLCSGAFLVLPLgAKFANDAGIVSVNWLIASYGLQSIGELMISGLGLA 405
|
410 420 430
....*....|....*....|....*....|..
gi 501048328 367 FISKFSPAKMLTAMMSVWVLATFFAGKSFGYV 398
Cdd:PRK09584 406 MVAQLVPQRLMGFIMGSWFLTTAGAALIAGYV 437
|
|
| MFS_POT |
cd06175 |
Proton-coupled oligopeptide transporter (POT) family of the Major Facilitator Superfamily of ... |
21-427 |
1.06e-20 |
|
Proton-coupled oligopeptide transporter (POT) family of the Major Facilitator Superfamily of transporters; The Proton-coupled oligopeptide transporter (POT) family is present across all major kingdoms of life and is known by a variety of names. It is referred to as the Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) in plants, and in addition to POT, it is also known as the Peptide transporter (PepT/PTR) or Solute Carrier 15 (SLC15) family in animals. Members of this family are proton-driven symporters involved in nitrogen acquisition in the form of di- and tripeptides. Plant members transport other nitrogenous ligands including nitrate, the plant hormone auxin, and glucosinolate compounds that are important for seed defense. POT proteins exhibit substrate multispecificity, with one transporter able to recognize as many as 8,400 types of di/tripeptides and certain peptide-like drugs. The POT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340865 [Multi-domain] Cd Length: 422 Bit Score: 93.65 E-value: 1.06e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 21 ERFAFYSAKWLITMFvaakiINGGLGLTPADGAKMSANLVAWTYFAPLIGSYISDRKIGARYLVPIGLIIMGVGYLV--- 97
Cdd:cd06175 11 ERFTFYGIGANLVPF-----LTGALGLGNAQAANVVLNFLGTSYVTPLFGGWIADTFLGRYRTILIGAAIYAVGVAIltv 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 98 ------------------GWKASSAGMINLMIILISIGTGLFKAQVNAITGRLFNDQK--QLDSAFSIQYSYVNIGSFIG 157
Cdd:cd06175 86 stippglrplrcnpshceQASGIQLTGFYAALYLIALGTGGVKANVSPLGADQFDERGpsKTQSFFNWFYFCINVGSLLA 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 158 TTTIGVLAGSMGYSFCFLICAIMTFIYAVIFifgwrflgdtgkkpfkidehkevkeakqeekkpltkiEKKRIGAIILIS 237
Cdd:cd06175 166 MLGTPYIQDNVGWAAAYGIPFVAILLALVVF-------------------------------------EVKQLLRALPLF 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 238 FFSIIFWIFWQlaYLPVYFYWGGDNgfANWMIGNFKVPTVWFDSLNALCCIVLGPILARVWAKLARRPQGDMSMFKKTAL 317
Cdd:cd06175 209 AFCILFWTVYA--QMTTSYVLQALT--LVRSTGLFTIPPASMQAFNPILLLLLIPVLDKVVYPLIRRYGVGLSPLTKIGL 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 318 GMLLLGLSYVIFAMADVTRGN-----------NLLPLAWLVVFGIILSLSEMVFSPLGNSFISKFSPAKMLTAMMSVWVL 386
Cdd:cd06175 285 GFFFGSLSMFVAGFLELKRLNtahahgpvvttSPLSFWWQIPQYLLLGIGEILVSITGLEFAYREAPKSMKGFIMGLLLL 364
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....
gi 501048328 387 AT----FFAGKSFGYVYEFTLKFKFAPT---------YFVIAAIAIVCGIILWA 427
Cdd:cd06175 365 TSgfgsFFGSVLVTLVSKPTDGAHIADDlnkgvltnfFFLLAVLAALNFLIFLL 418
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
65-429 |
1.91e-16 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 80.73 E-value: 1.91e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 65 FAPLIGSYISDRkIGARYLVPIGLIIMGVGYLVGWKASSAGMINLMIILISIGTGLFKAQVNAITGRLFNDqKQLDSAFS 144
Cdd:cd17329 50 VASLIGGRLADR-FGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTP-ENRTRAFS 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 145 IQYSYVNIGSFIGTTTIGVLAGSmGYSFCFLICAIMTFIYAVIFIFGwrflgdtgkkpFKIDEHKEVKEAKQEEKKPLTK 224
Cdd:cd17329 128 LLYWAINLGVAIGPLLGGLLLLY-SFRLLFLAAAVLFLLAALVLLFL-----------LPETRPKRRAAEKTEILRGYKI 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 225 IEKKRIGAIILISFFSIIFWIFWQLAYLPVYFywGGDNGFANWMIGnfkvptvWFDSLNALCCIVLGPILARVWAKLARR 304
Cdd:cd17329 196 VLRDRAFLLFLLASFLISLIYFQLESTLPVYV--VEILGLGESLLG-------LLLALNALLIVLLQFPVARLVERFRLR 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 305 PQGdmsmfkktALGMLLLGLSYVIFAMADVtrgnnllpLAWLVVFGIILSLSEMVFSPLGNSFISKFSPAKMLTAMMSV- 383
Cdd:cd17329 267 KIL--------MIGILLFAIGFAVLAFANT--------LAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFy 330
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 501048328 384 ---WVLATFFAGKSFGYVYEFtlkFKFAPTYFVIAAIAIVCGIILWALD 429
Cdd:cd17329 331 alaWGLGRAIGPLVGGLLLDL---LGPGLPWLILAALGLIAAALLLGLQ 376
|
|
| MFS_SLC15A1_2_like |
cd17347 |
Solute carrier family 15 members 1 and 2, and similar Major Facilitator Superfamily ... |
20-424 |
3.14e-16 |
|
Solute carrier family 15 members 1 and 2, and similar Major Facilitator Superfamily transporters; Solute carrier family 15 member 1 (SLC15A1) and SLC15A2 are members of the proton-coupled oligopeptide transporter (POT) family of integral membrane proteins that mediate the cellular uptake of di/tripeptides and peptide-like drugs. They mediate the proton-coupled active transport of a broad range of dipeptides and tripeptides, including zwitterionic, anionic and cationic peptides, as well as a variety of peptide-like drugs such as cefadroxil, enalapril, and valacyclovir. SLC15A1, or peptide transporter 1 (PepT1), is primarily expressed in the brush border membranes of enterocytes of the small intestine and is also known as the intestinal isoform. SLC15A2, or peptide transporter 2 (PepT2), is abundantly expressed in the apical membrane of kidney proximal tubules and is also referred to as the renal isoform. Both proteins transport di/tripeptides, but not tetrapeptides or free amino acids, using the energy generated by an inwardly directed transmembrane proton gradient. The SLC15A1/SLC15A2-like group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340905 [Multi-domain] Cd Length: 427 Bit Score: 80.35 E-value: 3.14e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 20 FERFAFYSAKWLITMFVAAKiinggLGLTPADGAKMSANLVAWTYFAPLIGSYISDRKIGaRYLVPIGLIIMgvgYLVGW 99
Cdd:cd17347 13 CERFSYYGMRAILVLYLTDF-----LGFSEAEATAIYHSFVMLCYFFPLLGAIIADSYLG-KYRTILYLSLV---YCLGH 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 100 KASSAGMINLMI-----------ILISIGTGLFKAQVNAITGRLF--NDQKQLDSAFSIQYSYVNIGSFIGTTTIGVL-- 164
Cdd:cd17347 84 IVLAVTAIPPLGpphvwglliglLLIAIGTGGIKPCVSAFGGDQFgaDQQHLLARFFSWFYFAINAGSLLSTFLTPILra 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 165 ----AGSMGYSFCFLICAIMTFIYAVIFIFGWRFLGDTgkkpfkidehkevkeakqeekKPLTKIekkrigaiilisffs 240
Cdd:cd17347 164 dvqfGGHDCYPLAFGVPGVLMAVATLVFWLGRKHYKDV---------------------KALLRV--------------- 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 241 iifwifwQLAYLPVYFYWG-GDNGFANW---------MIGNFKVPTVWFDSLNALCCIVLGPILARVWAKLARRPQGDMS 310
Cdd:cd17347 208 -------LVLFIPLPVFWAlFDQQGSRWtlqaeqmdgLVGGFTILPDQMQALNPILILILIPLFDYVIYPLLERCGIPLT 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 311 MFKKTALGMLLLGLSYVIFA--------MADVTRGNNL-----------LPLAWLVVFGIILSLSEMVFSPLGNSFISKF 371
Cdd:cd17347 281 PLRKMGVGMILAALAFVIAGflqlridgGLPGQPDPGEvttfediepnsVSILWQLPQYVVLTAGEVLFSITGLEFAYTQ 360
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|...
gi 501048328 372 SPAKMLTAMMSVWVLATFFAGKSFGYVYEFTLKFKFAPTYFVIAAIAIVCGII 424
Cdd:cd17347 361 APKSMKSVVQAAWLLTVALGNLIVVIVAELIQFSSQAAEYFFFAGLMLVVAVV 413
|
|
| PRK15462 |
PRK15462 |
dipeptide permease; |
1-392 |
1.73e-14 |
|
dipeptide permease;
Pssm-ID: 237971 [Multi-domain] Cd Length: 493 Bit Score: 75.37 E-value: 1.73e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 1 MENTKKMPTGFYFCSLAFTFERFAFYSAKWLITMFVAAKiinggLGLTPADGAKMSANLVAWTYFAPLIGSYISDRKIGA 80
Cdd:PRK15462 1 MNKHASQPRAIYYVVALQIWEYFSFYGMRALLILYLTNQ-----LKYDDNHAYELFSAYCSLVYVTPILGGFLADKVLGN 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 81 RYLVPIGLIIMGVGYLV-GWKASSAGMINLMIILISIGTGLFKAQVNAITGRLFN-DQKQLDSAFSIQYSYVNIGSFIGT 158
Cdd:PRK15462 76 RMAVMLGALLMAIGHVVlGASEIHPSFLYLSLAIIVCGYGLFKSNVSCLLGELYEpTDPRRDGGFSLMYAAGNVGSIIAP 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 159 TTIGVLAGSMGYSFCFLICAIMTFIYAVIFIFGWR-FLGDTGKKPFKIDEHKEV-----------------------KE- 213
Cdd:PRK15462 156 IACGYAQEEYSWAMGFGLAAVGMIAGLVIFLCGNRhFTHTRGVNKKVLRATNFLlpnwgwllvllvatpalitvlfwKEw 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 214 ---------------AKQEEKKPLTKIEKKRIGAIILISFFSIIFWIFWQLAYLPVYFYWggdNGFANWMIGNFKVPTVW 278
Cdd:PRK15462 236 svyalivatiiglgvLAKIYRKAENQKQRKELGLIVTLTFFSMLFWAFAQQGGSSISLYI---DRFVNRDMFGYTVPTAM 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 279 FDSLNALCCIVLGPILARVwAKLARRPQGDMSMFKKTALGMLLLGLSYVIFAMA---DVTRGNNLLPlawLVVFGI-ILS 354
Cdd:PRK15462 313 FQSINAFAVMLCGVFLAWV-VKESVAGNRTVRIWGKFALGLGLMSAGFCILTLSarwSAMYGHSSLP---LMVLGLaVMG 388
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 501048328 355 LSEMVFSPLGNSFISKFSPAKMLTAMMSVWVL-----ATFFAG 392
Cdd:PRK15462 389 FAELFIDPVAMSQITRIEIPGVTGVLTGIYMLlsgaiANYLAG 431
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
45-393 |
3.04e-14 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 73.47 E-value: 3.04e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 45 LGLTPAD-GAKMSANLVAWTYFAPLIGsYISDRkIGARYLVPIGLIIMGVGYLVGWKASSAGMINLMIILISIGTGLFKA 123
Cdd:COG2814 40 LGASPAQaGLVVTAYLLGAALGAPLAG-RLADR-FGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFP 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 124 QVNAITGRLFnDQKQLDSAFSIQYSYVNIGSFIGTTTIGVLAGSMGYSFCFLICAImtfIYAVIFIFGWRFLGDTGkkpf 203
Cdd:COG2814 118 AALALIADLV-PPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAV---LALLALLLLLRLLPESR---- 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 204 kidehkevKEAKQEEKKPLTKIEKKRIGAIILISFFSIIFWIFWQLAYLPVYFywGGDNGFANWMIGnfkvptvWFDSLN 283
Cdd:COG2814 190 --------PAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYL--QEVLGLSASAAG-------LLLALF 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 284 ALCCIVLGPILARVWAKLARRPQgdmsmfkkTALGMLLLGLSYVIFAMADvtrgnnllPLAWLVVFGIILSLSEMVFSPL 363
Cdd:COG2814 253 GLGGVLGALLAGRLADRFGRRRL--------LLIGLLLLALGLLLLALAG--------SLWLLLLALFLLGFGFGLLFPL 316
|
330 340 350
....*....|....*....|....*....|
gi 501048328 364 GNSFISKFSPAKMLTAMMSVWVLATFFAGK 393
Cdd:COG2814 317 LQALVAELAPPEARGRASGLYNSAFFLGGP 346
|
|
| PRK10207 |
PRK10207 |
dipeptide/tripeptide permease DtpB; |
8-402 |
4.23e-14 |
|
dipeptide/tripeptide permease DtpB;
Pssm-ID: 182306 Cd Length: 489 Bit Score: 74.09 E-value: 4.23e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 8 PTGFYFCSLAFTFERFAFYSAKWLITMFVAAKiinggLGLTPADGAKMSANLVAWTYFAPLIGSYISDRKIGARYLVPIG 87
Cdd:PRK10207 13 PRPFFMIFFVELWERFGYYGVQGILAVFFVKQ-----LGFSQEQAFITFGAFAALVYGLISIGGYVGDHLLGTKRTIVLG 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 88 LIIMGVGY-LVGWKASSAGMINLMIILISIGTGLFKAQVNAITGRLFNDQK-QLDSAFSIQYSYVNIGSFIGTTTIGVLA 165
Cdd:PRK10207 88 AIVLAIGYfMTGMSLLKPDLIFIALGTIAVGNGLFKANPASLLSKCYPPKDpRLDGAFTLFYMSINIGSLISLSLAPVIA 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 166 GSMGYSFCFLICAIMTFIYAVIFIFGWRFLGDTGKKPfkidEHKEVKEAKQ----------------------------- 216
Cdd:PRK10207 168 DKFGYSVTYNLCGAGLIIALLVYFACRGMVKDIGSEP----DHKPMSFSKLllvllgsvvmifvcawlmhnvevanlvli 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 217 -----------EEKKPLTKIEKKRIGAIILISFFSIIFWIFWqlAYLPVYFYWGGDNGFANWMIGnFKVPTVWFDSLNAL 285
Cdd:PRK10207 244 vlsivvtiiffREAFKLDKTGRNKMFVAFVLMLEAVVFYILY--AQMPTSLNFFAINNVHHEILG-FSINPVSFQALNPF 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 286 CCIVLGPILARVWAKLARRPQgDMSMFKKTALGMLLLGLSYVIFAMADVTRGNNL-LPLAWLVVFGIIL-SLSEMVFSPL 363
Cdd:PRK10207 321 WVVVASPILAGIYTHLGSKGK-DLSMPMKFTLGMFLCSLGFLTAAAAGMWFADAQgLTSPWFIVLVYLFqSLGELFISAL 399
|
410 420 430
....*....|....*....|....*....|....*....
gi 501048328 364 GNSFISKFSPAKMLTAMMSVWVLATFFAGKSFGYVYEFT 402
Cdd:PRK10207 400 GLAMIAALVPQHLMGFILGMWFLTQAAAFLLGGYVATFT 438
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
30-392 |
7.90e-11 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 63.21 E-value: 7.90e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 30 WLITMFVAAKIINGGLGLTPAD-GAKMSANLVAWTYFAPLIGsYISDRkIGARYLVPIGLIIMGVGYLVGWKASSAGMIN 108
Cdd:pfam07690 12 RSLLGPALPLLLAEDLGISPTEiGLLLTLFSLGYALAQPLAG-RLSDR-FGRRRVLLIGLLLFALGLLLLLFASSLWLLL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 109 LMIILISIGTGLFKAQVNAITGRLFNDqKQLDSAFSIQYSYVNIGSFIGTTTIGVLAGSMGYSFCFLICAIMTFIYAVIF 188
Cdd:pfam07690 90 VLRVLQGLGAGALFPAALALIADWFPP-EERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 189 IFGwrflgdtgkkpfkidehkevkeAKQEEKKPLTKIEKKRIGAIILISFFSIIFWIFWQLAYLPVYFYWGGDNGFANWM 268
Cdd:pfam07690 169 LLP----------------------RPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLY 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 269 IGNFKVPTVWFDSLNALCCIvLGPILARVWAKLARRpqgdMSMFKKTALGMLLLGLSYVIFAMADVTrgnnlLPLAWLVV 348
Cdd:pfam07690 227 QEVLGLSALLAGLLLGLGGL-LGAIGRLLLGRLSDR----LGRRRRLLLALLLLILAALGLLLLSLT-----LSSLWLLL 296
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 501048328 349 FGIILSLSEMVFSPLGNSFISKFSPAKMLTAMMSVWVLATFFAG 392
Cdd:pfam07690 297 ALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGG 340
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
36-428 |
1.58e-10 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 62.59 E-value: 1.58e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 36 VAAKIINGGLGLTPAD-GAKMSANLVAWTYFAPLIGsYISDRkIGARYLVPIGLIIMGVGYLVGWKASSAGMINLMIILI 114
Cdd:COG2223 26 VLAPPLAEEFGLSAAQlGLLFAIPVLVGALLRIPLG-FLVDR-FGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLL 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 115 SIGTGLFKAQVNAITGRLFNDQKQlDSAFSIQYSYVNIGSFIGTTTIGVLAGSMGYSFCFLICAIMTFIYAVIFIFGWRf 194
Cdd:COG2223 104 GIGGGGSFAVGIALVSKWFPPDRR-GLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLR- 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 195 lgdtgkkpfkiDEHKEVKEAKQEEKKPLTKIEKKRigaiilisffsiIFWIFWQLAYLPVYFYWGGDNGFANWMIGNFKV 274
Cdd:COG2223 182 -----------DPPAGAAAAAKASLRDQLEALRDP------------RFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 275 PTV---WFDSLNALCCIVLGPILARVWAKLARRpqgdmsmfKKTALGMLLLGLSYVIFAMAdvtrgnnLLPLAWLVVFGI 351
Cdd:COG2223 239 SAAtagLLAALFALLGALGRPLGGWLSDRIGGR--------RVLLIVFALMALGLLLLALA-------LGSLWLFLVLFL 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 352 ILSLSEMVFSPLGNSFISKFSPAKMLTAMMS----VWVLATFFAGKSFGYVYEFTLkfKFAPTYFVIAAIAIVCGIILWA 427
Cdd:COG2223 304 LLGLALGGGNGAVFALVPDIFPTKNAGAVYGlvgaAGGLGGFLGPLLFGALLDATG--SYTAAFLVFAVLALVALVLTLL 381
|
.
gi 501048328 428 L 428
Cdd:COG2223 382 L 382
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
34-425 |
2.65e-09 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 58.59 E-value: 2.65e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 34 MFVAAKIINGGLGLTPADGAKMSANLVAWTYFAPLIGSYISDRkIGARYLVPIGLIIMGVGYLVGWKASSAGMINLMIIL 113
Cdd:cd06174 15 ISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADR-FGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 114 ISIGTGLFKAQVNAITGRLFnDQKQLDSAFSIQYSYVNIGSFIGTTTIGVLAGSMGYSF--CFLICAIMTFIYAVIFIFG 191
Cdd:cd06174 94 LGLGSGLIDPAVLALIADLF-PERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWraVFLIAAALALLAAILLLLV 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 192 wrflgdtgkkpfkidehkeVKEAKQEEKKPLTKIEKKRIGAIILISFFSIIFWIFWqLAYLPVYFYWGGDNGFANWMIGN 271
Cdd:cd06174 173 -------------------VPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLL-LAIFLVNLAYYSFSTLLPLFLLD 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 272 FKVPTVWFDSLNALCCIVLGPILARVWAKLARRPQGDMSMFkktALGMLLLGLSYVIFAMADvtrgnnllPLAWLVVFGI 351
Cdd:cd06174 233 LGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLL---LIGLLLMALGLALLLLAP--------SLLLLLLLLL 301
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 501048328 352 ILSLSEMVFSPLGNSFISKFSPAKMLTAMMSVWVLATFFAGKSFGYVYEFTLKFKFAPTY-FVIAAIAIVCGIIL 425
Cdd:cd06174 302 LLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGaFLVLAVLLLLAAIL 376
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
45-191 |
5.37e-09 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 57.59 E-value: 5.37e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 45 LGLTPAD-GAKMSANLVAWTYFAPLIGsYISDRkIGARYLVPIGLIIMGVGYLVGWKASSAGMINLMIILISIGTGLFKA 123
Cdd:cd17325 230 GGLSPAQiGLLFGAQGLASALSQPPAG-KLSDR-IGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFP 307
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 501048328 124 QVNAITGRLFnDQKQLDSAFSIQYSYVNIGSFIGTTTIGVLAGSMGYSFCFLICAIMTFIYAVIFIFG 191
Cdd:cd17325 308 ATLALLADIV-PPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLL 374
|
|
| MFS_SLC15A1 |
cd17412 |
Solute Carrier family 15 member 1 of the Major Facilitator Superfamily of transporters; Solute ... |
59-388 |
1.09e-08 |
|
Solute Carrier family 15 member 1 of the Major Facilitator Superfamily of transporters; Solute carrier family 15 member 1 (SLC15A1), also called peptide transporter 1 (PepT1), is a member of the proton-coupled oligopeptide transporter (POT) family of integral membrane proteins that mediate the cellular uptake of di/tripeptides and peptide-like drugs. SLC15A1, as well as SLC15A2, mediate the proton-coupled active transport of a broad range of dipeptides and tripeptides, including zwitterionic, anionic and cationic peptides, as well as a variety of peptide-like drugs such as cefadroxil, enalapril, and valacyclovir. SLC15A1 is primarily expressed in the brush border membranes of enterocytes of the small intestine and is also known as the intestinal isoform. It is a high-capacity/low-affinity transporter that drives the transport of di-and tripeptides for metabolic purposes. It's expression is upregulated in the colon during chronic inflammation associated with inflammatory bowel disease. SLC15A1/PepT1 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340970 [Multi-domain] Cd Length: 415 Bit Score: 56.78 E-value: 1.09e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 59 LVAWTYFAPLIGSYISDRKIGARYLVpiglIIMGVGYLVGWKASSAGMINLM----------------------IILISI 116
Cdd:cd17412 47 FVALCYLTPILGAIIADSWLGKFKTI----VYLSIVYTIGQAVMAVSAIHDLtdanrdgtpdnltlhvalsmigLLLIAL 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 117 GTGLFKAQVNAITGRLFND--QKQLDSAFSIQYSYVNIGSFIGTTTIGVLAGS--------MGYSFCFLICAIMTFIYAV 186
Cdd:cd17412 123 GTGGIKPCVAAFGGDQFEEhqEKQRSRFFSIFYLSINAGSLLSTIITPILRSQecgihskqKCYPLAFGVPAALMVVALI 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 187 IFIFGwrflgdtgkkpfkideHKEVKEAKQeekkpLTKIekkrigaiilisffsiifwifwQLAYLPVYFYWG-GDNGFA 265
Cdd:cd17412 203 VFILG----------------SKMYKQIKM-----VLKV----------------------LFLYIPLPMFWAlFDQQGS 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 266 NW------MIGNFKVPTVWFDSL---NALCCIVLGPILARVWAKLARRPQGDMSMFKKTALGMLLLGLSYVIFAMADVTr 336
Cdd:cd17412 240 RWtlqattMDGNFGAIQIQPDQMqtvNPILIIIMVPIFDAVIYPLIKKCKINFTPLRKMTVGMFLAALAFVAAALLQIQ- 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 501048328 337 gnnllpLAWLVVFGIILSLSEMVFSPLGNSFISKFSPAKMLTAMMSVWVLAT 388
Cdd:cd17412 319 ------MAWQIPQYFLLTCGEVVFSVTGLEFSYSQAPSNMKSVLQAGWLLTV 364
|
|
| MFS_PTR2 |
cd17350 |
Peptide transporter PTR2 of the Major Facilitator Superfamily of transporters; Fungal peptide ... |
21-427 |
1.58e-08 |
|
Peptide transporter PTR2 of the Major Facilitator Superfamily of transporters; Fungal peptide transporter or permease PTR2 is a member of the proton-coupled oligopeptide transporter (POT) family of integral membrane proteins that mediate the cellular uptake of di/tripeptides and peptide-like drugs. It is a 12-transmembrane domain (TMD) integral membrane protein that translocates di-/tripeptides. As with other POT family proteins, it displays characteristic substrate multispecificity. PTR2 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340908 [Multi-domain] Cd Length: 438 Bit Score: 56.32 E-value: 1.58e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 21 ERFAFYSAKWLITMFVAAKIIN---GGLGLTPADGAKMSANLVAWTYFAPLIGSYISDRKIGARYLVPIGLIIMGVGYL- 96
Cdd:cd17350 14 ERFSYYGLTGPFQNYMQFGPDDstpGALGLGEQGATGLSNFFTFWCYVTPVIGAYVADQFLGRYNTIVCGAVIYFVGILi 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 97 --------VGWKASSAGMINLMIILISIGTGLFKAQVNAI----------------TGR--LFNDQKQLDSAFSIQYSYV 150
Cdd:cd17350 94 ltctsipsVIDAGAGLGGFVVAIIIIGLGTGGIKSNVSPLiadqlpkikpyvktlkNGErvIVDPVVTLSRIYMIFYWAI 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 151 NIGSF--IGTTTigvLAGSMGYSFCFLICAIMTFIYAVIFIFgwrflgdtGKKPFKIDEHKEVKEAKQeekkpltkiekk 228
Cdd:cd17350 174 NVGSLslLATTY---LERTKGFWYAYLLPLCVFVIPLIILAF--------GKKFYKIRPDLFIDELKR------------ 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 229 rigaiiliSFFSIIFWIFWQLaylpvyfYWGGDNGFANWMI---GNFK---VPTVWFDSLNALCCIVLGPILARVWAKLA 302
Cdd:cd17350 231 --------ALRACKVFLFYPI-------YWVCYGQMTSNFIsqaGQMQlhgVPNDLFQAFDSIALIIFIPILENIIYPLL 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 303 RRPQGDMSMFKKTALGMLLLGLSYVIFAM--------------ADVTRGNNLLPLAWLVVFGIILSLSEMVFSPLGNSFI 368
Cdd:cd17350 296 RKYNIPFKPITRITLGFMFASFSMIYAAVlqakiyqagpcyanPTGTCSPNDIHVWIQIPAYVLIAFSEIFASITGLEYA 375
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*....
gi 501048328 369 SKFSPAKMLTAMMSVWVLATFFAGKSFGYVYEFTLKFKFAPTYFVIAAIAIVCGIILWA 427
Cdd:cd17350 376 YTKAPPSMKSFITALFLLTNAFGAALSIAISPAAVDPKLTWMFTGIAVAAFIAGIMFWL 434
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
23-193 |
3.25e-08 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 55.26 E-value: 3.25e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 23 FAFYSAKWLITMFVAAKIINGGLGLTPADGAKMSANLVAWTYFAPLIGSYISDR-KIGARYLVPIGLIIMGVGYLVGWKA 101
Cdd:COG2271 189 YFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRlGRRRKLVLAIGLLLAALALLLLALL 268
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 102 SSAGMINLMIILISIGTGLFKAQVNAITGRLFnDQKQLDSAFSIQYSYVNIGSFIGTTTIGVLAGSMGYSFCFLICAIMT 181
Cdd:COG2271 269 PSPALAIALLFLAGFGLGGAFGLLWALAAELF-PKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALA 347
|
170
....*....|..
gi 501048328 182 FIYAVIFIFGWR 193
Cdd:COG2271 348 LLAALLALLLLR 359
|
|
| MFS_SLC15A2 |
cd17411 |
Solute carrier family 15 member 2 of the Major Facilitator Superfamily of transporters; Solute ... |
64-390 |
7.09e-08 |
|
Solute carrier family 15 member 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 15 member 2 (SLC15A2), also called peptide transporter 2 (PepT2), is a member of the proton-coupled oligopeptide transporter (POT) family of integral membrane proteins that mediate the cellular uptake of di/tripeptides and peptide-like drugs. SLC15A2, as well as SLC15A1, mediate the proton-coupled active transport of a broad range of dipeptides and tripeptides, including zwitterionic, anionic and cationic peptides, as well as a variety of peptide-like drugs such as cefadroxil, enalapril, and valacyclovir. SLC15A2 is a high-affinity transporter and is abundantly expressed in the apical membrane of kidney proximal tubules and choroid plexus epithelial cells. It is the major transporter involved in the reclamation of peptide-bound amino acids and peptide-like drugs in the kidney, and is also called the renal isoform. In choroid plexus and the brain, it acts as an efflux transporter and plays a role in regulating peptide/neuropeptide homeostasis. SLC15A2/PepT2 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340969 [Multi-domain] Cd Length: 403 Bit Score: 54.45 E-value: 7.09e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 64 YFAPLIGSYISDRKIGA-------RYLVPIGLIIMGVGYLVGWKASSAGMINLMI--ILISIGTGLFKAQVNAITGRLFN 134
Cdd:cd17411 52 YFTPVLGALIADSWLGKfktiiylSIVYVVGHVIKSVGAIPTVGDQQVHVVLSMIglFLIALGTGGIKPCVAAFGGDQFE 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 135 DQ--KQLDSAFSIQYSYVNIGSFIGTTTIGVLAGSMG------YSFCFLICAIMTFIYAVIFIFGWRFlgdtgkkpfkid 206
Cdd:cd17411 132 EEhaRERSKFFSIFYLSINAGSLISTFVTPILRGDVQcfggdcYALAFGVPAALMVVALVVFIAGSGM------------ 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 207 eHKEVKEakqeekkpLTKIekkrigaiilisffsiifwifwQLAYLPVYFYWG-GDNGFANWMI---------GNFKVPT 276
Cdd:cd17411 200 -YKEVKM--------VTRV----------------------LFLYIPLPMFWAlFDQQGSRWTLqatrmndfgGGFVLQP 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 277 VWFDSLNALCCIVLGPILARVWAKLARRPQGDMSMFKKTALGMLLLGLSYVIFAMADVTrgnnllpLAWLVVFGIILSLS 356
Cdd:cd17411 249 DQMQTLNPLLILVFIPIFDLGIYPLVSKCKINFTSLRKMATGMILAALAFAVAAAVEIK-------IAWQLPQYVLLSAG 321
|
330 340 350
....*....|....*....|....*....|....
gi 501048328 357 EMVFSPLGNSFISKFSPAKMLTAMMSVWVLATFF 390
Cdd:cd17411 322 EVMFSITGLEFSYSQAPASMKSVLQAGWLLTVAF 355
|
|
| 2A1704 |
TIGR00926 |
Peptide:H+ symporter (also transports b-lactam antibiotics, the antitumor agent, bestatin, and ... |
59-335 |
1.16e-07 |
|
Peptide:H+ symporter (also transports b-lactam antibiotics, the antitumor agent, bestatin, and various protease inhibitors); [Transport and binding proteins, Amino acids, peptides and amines]
Pssm-ID: 273343 [Multi-domain] Cd Length: 654 Bit Score: 54.00 E-value: 1.16e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 59 LVAWTYFAPLIGSYISDRKIGARYLVPIGLIIMGVGYLV---GWKASSAGMIN-----LMIILISIGTGLFKAQVNAITG 130
Cdd:TIGR00926 32 FTYLCYLTPLIGAIIADGWLGKFKTILYLSIVYVVGHALlsfGAIPSSGHPLHdlldlLGLALIALGTGGIKPCVSAFGG 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 131 RLFNDQ--KQLDSAFSIQYSYVNIGSFIGTTTIGVLAGSMG-------YSFCFLICAIMTFIYAVIFIFGWRFL------ 195
Cdd:TIGR00926 112 DQFEERqlSLRSRFFSFFYFAINAGSLISTIITPILRGDVGcfgcqdcYPLAFGVPAILMILALIVFMAGSKMYkkkppk 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 196 -GDTGKKPFKIDEHKEVKEAKQEEKKPLTKIEKKRIGAIILISFFSIIFWIFWQLaYLPVYFYWG-GDNGFANWMI---- 269
Cdd:TIGR00926 192 gNIVSKVIKCIVTALRKRFSTRSEHWPLHWLDYAKDKHDIRMIRSTKRLLRVLVL-FIPLPMFWAlFDQQGSRWTLqatr 270
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 501048328 270 -----GNFKVPTVWFDSLNALCCIVLGPILARVWAKLARRPQGDMSMFKKTALGMLLLGLSYVIFAMADVT 335
Cdd:TIGR00926 271 mdgdvGGFEIQPDQMQVVNPLLILIFVPIFDYIVYPAIAKCGTRFTSLRKMAVGGLLAALSFFVAALVQLK 341
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
52-190 |
2.32e-06 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 49.49 E-value: 2.32e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 52 GAKMSANLVAWTYFAPLIGSYISDR---KIGARYLVPIGLIIMGVGYLVGWKASSAGMINLMIILISIGTGLFKAQVNAI 128
Cdd:cd17473 231 SAALIGLALAIASLAGAIGALLFGRlkrRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSW 310
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 501048328 129 TGRLFNDQkQLDSAFSIQYSYVNIGSFIGTTTIGVL-AGSMGYSFCFLICAIMTFIYAVIFIF 190
Cdd:cd17473 311 AMSLVPPE-LRGRAMGIVTSAFFLGQFLSPLVLGPLvNLTGGLSGAFLILGVLALVLAIVLLL 372
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
65-428 |
3.85e-06 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 48.73 E-value: 3.85e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 65 FAPLIGsYISDRkIGARYLVPIGLIIMGVGYLVGWKASSAGMINLMIILISIGTGLFKAQVNAITGRLFnDQKQLDSAFS 144
Cdd:cd17325 47 FSPPAG-RLSDR-FGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPAAMALIADIA-PPEERGRAMG 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 145 IQYSYVNIGSFIGTTTIGVLAGSMGYSFCFLICAIMTFIyavIFIFGWRFLGDTGKKPfkideHKEVKEAKQEEKKPLTK 224
Cdd:cd17325 124 IFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALL---ALVLALLLLPEPRPPP-----NKRAVSAARLRSGLRLL 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 225 IEKKRIGAIILISFFSIIFWIFWQlAYLPVYFYwgGDNGFANWMIGnfkvptvWFDSLNALCCIVLGPILARVWAKLARR 304
Cdd:cd17325 196 LRDRRLLALFLAIFVLAFAFGALE-PFLPLYAA--ELGGLSPAQIG-------LLFGAQGLASALSQPPAGKLSDRIGRK 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 305 PQGdmsmfkktALGMLLLGLSYVIFAMADvtrgnnllPLAWLVVFGIILSLSEMVFSPLGNSFISKFSPAKMLTAMM--- 381
Cdd:cd17325 266 PLI--------LIGLLLSAVALLLLPLAT--------SFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMglf 329
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 501048328 382 -SVWVLATFFAGKSFGYVYEftlKFKFAPTYFVIAAIAIVCGIILWAL 428
Cdd:cd17325 330 nTAFSLGMVLGPLLGGFLYD---AFGFATPFLAAAALLLLAAVLFLLL 374
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
65-189 |
4.07e-06 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 48.69 E-value: 4.07e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 65 FAPLIGsYISDRkIGARYLVPIGLIIMGVGYLVGWKASSAGMINLMIILISIGTGLFKAQVNAITGRLFNDQKQlDSAFS 144
Cdd:cd17370 250 AAYPAG-RLSDR-IGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELR-GTAYG 326
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 501048328 145 IQYSYVNIGSFIGTTTIGVLAGSMGYSFCFLICAIMTFIYAVIFI 189
Cdd:cd17370 327 LFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLLLL 371
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
86-428 |
4.59e-06 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 48.77 E-value: 4.59e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 86 IGLIIMGVGYLVGWKASSAGMINLMIILISIGTGLFKAQVNAITGRLFNDqKQLDSAFSIQYSYVNIGSFIGTTTIGVLA 165
Cdd:cd06173 74 RALLAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPK-EQLVRANALNSLATQLARIIGPALGGLLV 152
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 166 GSMGYSFCFLICAImTFIYAVIFIFGWRFlgdtgkkpfkidehkevKEAKQEEKKPLTKIEKKRIGAIILISFFSIIFWI 245
Cdd:cd06173 153 ALLGPGGAFAINAL-SFLLSALLLLFIRR-----------------PPPAAPGESSSLLLRDLREGLRYLRRSPLLRLLL 214
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 246 FWQLAYLpvyFYWGGDN-GFANWMIGNFKVPTVWFDSLNALCCI--VLGPILArvwAKLARRpqgdMSMFKKTALGMLLL 322
Cdd:cd06173 215 LALALFA---LLGGALTvLLPLLAKEVLGGGAAGYGLLLAAFGVgaLLGALLL---GRLSKR----RRRGRLLLIGALLL 284
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 323 GLSYVIFAMAdvtrgnnlLPLAWLVVFGIILSLSEMVFSPLGNSFISKFSPAKMLTAMMSVWVLATFFAGKSFGYVYEFT 402
Cdd:cd06173 285 GLALLVLGLS--------PSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLL 356
|
330 340
....*....|....*....|....*.
gi 501048328 403 LKFKFAPTYFVIAAIAIVCGIILWAL 428
Cdd:cd06173 357 ADALGLSAVFLLAGALLLLAALLLLL 382
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
36-428 |
1.20e-05 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 47.17 E-value: 1.20e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 36 VAAKIINGGLGLTPAD-GAKMSANLVAWTYFAPLIGsYISDRkIGARYLVPIGLIIMGVGYLVGWKASSAGMINLMIILI 114
Cdd:COG2271 31 VAAPPLQADLGLSAAQlGLLASAFFLGYALGQIPAG-LLADR-FGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 115 SIGTGLFKAQVNAITGRLFnDQKQLDSAFSIQYSYVNIGSFIGTTTIGVLAGSMGYSFCFLICAIMTFIYAVIFIFGwrf 194
Cdd:COG2271 109 GLGEAGFFPAALKLIAEWF-PPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLALLRFWL--- 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 195 lgdtgkkpfkidehkevkeakqeekkpltkiekkrIGAIILISFFSIIFWIFWQLAYLPVYFywGGDNGFANWMIgnfkv 274
Cdd:COG2271 185 -----------------------------------LALAYFLVYFALYGFLTWLPTYLVEVR--GLSLAQAGLLL----- 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 275 ptvwfdSLNALCCIVLGPILARVWAKLARRPQGDMsmfkktALGMLLLGLSYVIFAMADvtrgNNLLPLAWLVVFGIILS 354
Cdd:COG2271 223 ------SLPFLAGIVGSLLGGWLSDRLGRRRKLVL------AIGLLLAALALLLLALLP----SPALAIALLFLAGFGLG 286
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 501048328 355 LSEMVFSPLGNSFISKFSPAKMLTAMMSVWVLATFFAGKSFGYVYEFTlkfKFAPTYFVIAAIAIVCGIILWAL 428
Cdd:COG2271 287 GAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDAT---GYQAAFLLLAALALLAALLALLL 357
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
67-190 |
1.84e-05 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 46.82 E-value: 1.84e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 67 PLIGSyISDRKIGARYLVPiGLIIMGVGYLVGWKASSAGMINLMIILISIGTGLFKAQVNAITGRLfNDQKQLDSAFSIQ 146
Cdd:cd17489 245 PFSGK-LSDRKGPKTVIIP-GLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDL-VPPHRRGAANGTF 321
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 501048328 147 YSYVNIGSFIGTTTIGVLAGSMGYSFCFLICAIMTFIYAVIFIF 190
Cdd:cd17489 322 FIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIF 365
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
23-425 |
1.06e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 44.51 E-value: 1.06e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 23 FAFYSAKWLITMFVAAKIINGGLGLTPADGAKMSANLVAWTYFAPLIGSYISDR---KIGAR--YLVpIGLIIMGVGYLV 97
Cdd:COG2211 19 DLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRtrtRWGRRrpWIL-IGAIPLALSFVL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 98 GWKASSAGMINLMI------ILISIGTGLFKAQVNAITGRLFNDQKQLDSAFSIQYSYVNIGSFIGTTTIGVLAGSM--- 168
Cdd:COG2211 98 LFTAPDLSPTGKLIyalvtyLLLGLAYTLVNIPYSALGAELTPDYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFggd 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 169 ---GYSFCFLICAIMTFIYAVIFIFGWRflgdtgkkpfkidEHKEVKEAKQEEKKPLTKIekKRIGAIILISFFSIIFWI 245
Cdd:COG2211 178 aalGYRLTALIFAVLGLLAFLLTFFGTK-------------ERPVPEEEKVSLKESLKAL--LKNRPFLLLLLAYLLFFL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 246 FWQL--AYLPVYF--YWGGDNGFANWMIGnfkvptvwfdsLNALCCIVLGPILARVWAKLARRpqgdmsmfKKTALGMLL 321
Cdd:COG2211 243 ALALvaALLLYYFkyVLGLSAALVGLLLA-----------LYFLAALLGAPLWPRLAKRFGKK--------KAFIIGLLL 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 322 LGLSYVIFAMADVTrgnnllPLAWLVVFGIILSLSEMVFSPLGNSFISKFSPAKMLT-------AMMSVWVLATFFAG-- 392
Cdd:COG2211 304 AALGLLLLFFLGPG------NLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKtgrrregLYFGIFTFAIKLGQal 377
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 501048328 393 ---------KSFGYVYEFT----LKFKFAPTYFVIAAIAIVCGIIL 425
Cdd:COG2211 378 agalaglllALFGYVAGAAqspsALTGIRLLFFLLPAVLLLLAALL 423
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
23-190 |
1.93e-04 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 43.33 E-value: 1.93e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 23 FAFYSAKWLITMFVAAKIINGGLGLTPA-------DGAKMSANLVAWTYFAPLIG--------SYISDRKIGARYLVPIG 87
Cdd:cd17474 192 KKALRGRGLLTFLVSAFLYFFLYFAFLTylpflleLLYGISPIIIGLLFAGWSVLlalgslfvGRLLKKRFGARRILVIG 271
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 88 LIIMGVGYLVGWKASSAGMINLMIILISIGTGLFKAQVNAITGRLFNdqKQLDSAFSIQYSYV-NIGSFIGTTTIGVLAG 166
Cdd:cd17474 272 LLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAP--EEERGTASSLYNFVrFLGQAVGPLLFGLLLE 349
|
170 180
....*....|....*....|....
gi 501048328 167 SMGYSFCFLICAIMTFIYAVIFIF 190
Cdd:cd17474 350 IFGLSAPFLVGAAIALAAAVLLAL 373
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
36-190 |
2.94e-04 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 42.49 E-value: 2.94e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 36 VAAKIINGGLGLTPAD-GAKMSANLVAWTYFAPLIGsYISDRkIGARYLVPIGLIIMGVGYLVGWKASSAGMINLMIILI 114
Cdd:COG0477 35 VALPSIAADLGASSAQlGWIVSAYLLGRAIGLLLFG-RLGDR-YGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQ 112
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 501048328 115 SIGTGLFKAQVNAITGRLFNDqKQLDSAFSIQYSYVNIGSFIGTTTIGVLAGSMGYSFCFLICAIMTFIYAVIFIF 190
Cdd:COG0477 113 GIGAGGLMPGALALIAELFPA-RERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLALVLRLR 187
|
|
| MFS_NPF6 |
cd17413 |
NRT1/PTR family (NPF), subfamily 6 of the Major Facilitator Superfamily of transporters; The ... |
43-336 |
2.98e-04 |
|
NRT1/PTR family (NPF), subfamily 6 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter 1/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF6 includes the first identified member of the NRT1/PTR family: Arabidopsis thaliana NRT1.1, now called AtNPF6.3. It is a dual affinity nitrate influx transporter and a nitrate sensor. It also transports auxin and has nitrate efflux activity. NPF6 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340971 [Multi-domain] Cd Length: 457 Bit Score: 43.21 E-value: 2.98e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 43 GGLGLTPADGAKMSANLVAWTYFAPLIGSYISDRKIGARYLVPIGLIIMGVGYLV------------------------- 97
Cdd:cd17413 31 GTMHLPSATSANIVTNFLGTSFLLCLLGGFIADTFLGRYLTIAIFASIQALGVLVltlsttlpslrpppcnhttshhcep 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 98 --GWKASsagMINLMIILISIGTGLFKAQVNAITGRLFND-----QKQLDSAFSIQYSYVNIGSFIGTTTIGVLAGSMGY 170
Cdd:cd17413 111 asGIQLT---VLYLALYLIALGTGGIKSSVSGFGSDQFDEndpkeRKLMSYFFNRFFFCISVGSLLAVTVLVYIQDNVGR 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 171 SFCFLICAIMTFIYAVIFIFG---WRFlgdtgKKPFKIDEHKEVKEAKQeekkpLTKIEKKRIgaiilisffsiifwIFW 247
Cdd:cd17413 188 GWGYGICAAAMVLAIVVFLAGtkrYRF-----KKSIGSTQVEEVKMVVR-----MLPIWATTI--------------LFW 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 248 QLaYLPVYFYWGGDNGFANWMIGNFKVP----TVWFDSLNALCCIVLGPILARVWAKLARRPQGdMSMFKKTALGMLLLG 323
Cdd:cd17413 244 TV-YAQMTTFSVEQAETMDRNIGSFEIPpasmAVFLVATILLTTAVYDRVIVPLCRKLTGHPQG-LTTLQRIGVGLVFSC 321
|
330
....*....|...
gi 501048328 324 LSYVIFAMADVTR 336
Cdd:cd17413 322 LAMAVAALVELKR 334
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
65-428 |
4.03e-04 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 42.56 E-value: 4.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 65 FAPLIGsYISDRkIGARYLVPIGLIIMGVGYLVGWKASSAGMINLMIILISIGTGLFKAQVNAITGRLFNDQKQlDSAFS 144
Cdd:cd17473 51 FAPLAG-WLADR-FGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEER-AKMLG 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 145 IQYSYVNIGSFIGTTTIGVLAgSMGYSFCFLIcaimtfiYA---VIFIFGWRFLGDTGKKpfkideHKEVKEAKQEEKKP 221
Cdd:cd17473 128 LQSAAMSLGGVVFLLLGGALA-EIGWRAPFLV-------YLlalPVLILVLLFLPEPARK------SKSAASPGAATAAA 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 222 LTKIEKKRIGAIILISFFSiifwIFWQLAYLPvyFYWGGDNGFANWMIGnfkvptvWFDSLNALCCIVLGPILARVWAKL 301
Cdd:cd17473 194 LPWKRVLPIYFLAFLAMLL----FYVIPIQLP--FLLQERGGGSAALIG-------LALAIASLAGAIGALLFGRLKRRL 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 302 ARRpqgdmsmfKKTALGMLLLGLSYVIFAMAdvtrGNNLLPLAWLVVFGIILSLSEmvfsPLGNSFISKFSPAKMLTAMM 381
Cdd:cd17473 261 GKR--------RLLAIGFALMALGFLLLALA----SGLWVVLLGAILAGLGFGLLL----PTLNSWAMSLVPPELRGRAM 324
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 501048328 382 SVWVLATFFAGKSFGYVYEF--TLKFKFAPTYFVIAAIAIVCGIILWAL 428
Cdd:cd17473 325 GIVTSAFFLGQFLSPLVLGPlvNLTGGLSGAFLILGVLALVLAIVLLLL 373
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
45-189 |
4.21e-04 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 42.41 E-value: 4.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 45 LGLTPADGAKMSANLVAWTYFAPLIGSYISDRKIGARYLVPIGLIIMGVGYLVGWKASSAGMINLMIILISIGTGLFKAQ 124
Cdd:cd06174 234 GGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPL 313
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 501048328 125 VNAITGRLFNDQKQLdSAFSIQYSYVNIGSFIGTTTIGVLAGSM-GYSFCFLICAIMTFIYAVIFI 189
Cdd:cd06174 314 SFALIAELFPPEIRG-TAFGLLNTFGFLGGAIGPLLAGFLLAATfGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_NPF7 |
cd17419 |
NRT1/PTR family (NPF), subfamily 7 of the Major Facilitator Superfamily of transporters; The ... |
45-194 |
4.69e-04 |
|
NRT1/PTR family (NPF), subfamily 7 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF7 includes the nitrate transporters AtNPF7.2 and AtNPF7.3, as well as the dipeptide transporter OsNPF7.3. AtNPF7.3 is a bidirectional transporter involved in nitrate influx and efflux. NPF7 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340977 [Multi-domain] Cd Length: 447 Bit Score: 42.36 E-value: 4.69e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 45 LGLTPADGAKMSANLVAWTYFAPLIGSYISDRKIGaRYLVP--------IGLIIM--------------GVGYLVGWKAS 102
Cdd:cd17419 33 MHQSNASAANNVSNWTGTVYITPLIGAFLSDSYWG-RYWTStlfqaifvIGLLLLtlssalpslrppqcGDGDLKCPPAS 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 103 SA--GMINLMIILISIGTGLFKAQVNAITGRLFNDQKQLDSA-----FSIQYSYVNIGSFIGTTTIGVLAGSMGYSFCFL 175
Cdd:cd17419 112 AAqtTFLYFSLYLIALGYGGYQPCIATLGADQFDDEDPIEKAsksafFSYFYQALNLGSLFSNTILVYFEDNGSWGLGFG 191
|
170
....*....|....*....
gi 501048328 176 ICAIMTFIYAVIFIFGWRF 194
Cdd:cd17419 192 ISAGAAFIGLVLFLAGTPF 210
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
67-195 |
5.26e-04 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 42.16 E-value: 5.26e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 67 PLIGsYISDRKiGARYLVPIGLIIMGVG-YLVGWkASSAGMINLMIILISIGTGLFKAQVNAITGRLFNDQKQLdsAFSI 145
Cdd:cd17478 49 PLFG-YLADRK-PRRYLLPLGPLLTGLGlSLLGF-APNYWLLLLLVALAGIGSAAFHPEGARLASQAAGGRRGL--AMSI 123
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 501048328 146 QYSYVNIGSFIGTTTIGVLAGSMGYSFCFLICAIMtFIYAVIFIFGWRFL 195
Cdd:cd17478 124 FSVGGNLGFALGPLIAAALVALFGGLGLLILLIIP-GLAVALLLLRLRPL 172
|
|
| MFS_NPF4 |
cd17414 |
NRT1/PTR family (NPF), subfamily 4 of the Major Facilitator Superfamily of transporters; The ... |
45-194 |
1.12e-03 |
|
NRT1/PTR family (NPF), subfamily 4 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. Members of the NPF4 subfamily have been shown to transport ABA. NPF4 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340972 [Multi-domain] Cd Length: 456 Bit Score: 41.24 E-value: 1.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 45 LGLTPADGAKMSANLVAWTYFAPLIGSYISDRKIG--ARYLVP-----IGLIIMGV-----------GYLVGW------K 100
Cdd:cd17414 33 MHYSLAKSANIVTNFVGTAFLLALLGGFLSDSFLSsfKTIIIFgsielLGLILLTVqahipslqppsCNSLGDltckepS 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 101 ASSAGMINLMIILISIGTGLFKAQVNAITGRLFND-----QKQLDSAFSIQYSYVNIGSFIGTTTIGVLAGSMGYSFCFL 175
Cdd:cd17414 113 GSQAAILFVGLYLVALGVGCIKPNLPSHGADQFDEndpkgRRQLSSFFNWYYFSFSLGALIAVTLVVWVEENKGWDWGFG 192
|
170
....*....|....*....
gi 501048328 176 ICAIMTFIYAVIFIFGWRF 194
Cdd:cd17414 193 VSAAVIAVGILVFVAGTPF 211
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
53-194 |
1.36e-03 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 40.99 E-value: 1.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 53 AKMSANLVAWTYFAPLIGSYISD---RKIGARYLVPIGLIIMGVGYLVGWKASSAGMINLMIILISIGTGLFKAQVNAIT 129
Cdd:COG0738 245 EATAALGLSLFWGGMTIGRFLGGfllKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLA 324
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 501048328 130 GRLFNdqKQLDSAFSIQYSYVNIGSFIGTTTIGVLAGSMGYSFCFLICAIMtfiYAVIFIFGWRF 194
Cdd:COG0738 325 LDGLG--KRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVC---YLLILLLALAL 384
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
65-189 |
1.56e-03 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 40.63 E-value: 1.56e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 65 FAPLIGsyisdRKIGARYLVPIGLIIMGVGYLVGWKASSAGMINLMIILISIGTGLFKAQVNAITGRLFNDQKQLdsAFS 144
Cdd:COG2807 72 LAPRLA-----RRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDRVGL--MTG 144
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 501048328 145 IQYSYVNIGSFIGTTTIGVLAGSMGYSFCFLICAIMTFIYAVIFI 189
Cdd:COG2807 145 LYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWL 189
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
32-196 |
2.23e-03 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 39.86 E-value: 2.23e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 32 ITMFVAAKIINGGLGLTPAD-GAKMSANLVAWTyFAPLIGSYISDRkIGARYLVPIGLIIMGVG-YLVGWKASSAGMINL 109
Cdd:cd17319 20 VNISVAAPTIMKDLGLSPTQyGLIASAFFLGYA-LFQVPGGWLLDR-FGARKVLAVSMLLWSLFtALTGFATSLTSLYVL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 110 MIILISIGTGLFKAQVNAITGRLfnDQKQLDSAFSIQYSYVNIGSFIGTTTIGVLAGSMGYSFCFLICAIMTFIYAVI-F 188
Cdd:cd17319 98 RFLLGVAEAGFFPGAIKALAEWF--PARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLwW 175
|
....*...
gi 501048328 189 IFGWRFLG 196
Cdd:cd17319 176 FYLRQVWG 183
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
59-190 |
2.95e-03 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 39.95 E-value: 2.95e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 59 LVAWTYFAPLIGSYISDRkIGARYLVPIGLIIMGVGYLV------GWKASSAGMINLMIILISIGTGLFKAQVNA----I 128
Cdd:pfam00083 296 VGVVNFVFTFIAIFLVDR-FGRRPLLLLGAAGMAICFVIlgivalLGVSKSDWAGIVAIVFIALFIAFFAMGWGPvpwvI 374
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 501048328 129 TGRLFnDQKQLDSAFSIQYSYVNIGSFIGTTTIGVLAGSMGYSFCFLI---CAIMTFIYAVIFIF 190
Cdd:pfam00083 375 VSELF-PLSVRSKAMALATAANWLANFLIGFLFPIITDAIGLGYTFFIfagLLVLFIIFVFFFVP 438
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
14-187 |
5.23e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 39.10 E-value: 5.23e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 14 CSLAFTFERFAFYSAkwLITMFVAAKIINGGLGLTPAdGAKMSANLVAWTYFAPLIGSYIsdRKIGARYLVPIGLIIMGV 93
Cdd:cd17504 185 TALLAGFGMFMVFQL--LPQLLQLPTPTGFGLGITEA-GLLLLPGALVMLIAGPLAGRLI--ARVGPRRVLLIGLVISAV 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 94 GYL-VGWKASSAGMINLMIILISIGTGL-FKAQVNAITGRLfnDQKQLDSAFSIQYSYVNIGSFIGT------------- 158
Cdd:cd17504 260 GLLlLALLHSSLWALVVALLLIGIGLGLaFASLPNIVVESV--PPDRTGIATGMNTVLRTIGSAIGPaiagailttytvs 337
|
170 180
....*....|....*....|....*....
gi 501048328 159 TTIGVLAGSMGYSFCFLICAIMTFIYAVI 187
Cdd:cd17504 338 ITSGGVPTEGAYVLAFLIGAALALAALLL 366
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
23-154 |
5.39e-03 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 38.80 E-value: 5.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 23 FAFYSAKWLITMFVAAKIINGGLGLTPAD-GAKMSANLVAWTYFAPLIGsYISDRkIGARYLVPIGLIIMGVGYLVGWKA 101
Cdd:COG2814 216 AFLLGFGFFALFTYLPLYLQEVLGLSASAaGLLLALFGLGGVLGALLAG-RLADR-FGRRRLLLIGLLLLALGLLLLALA 293
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 501048328 102 SSAGMINLMIILISIGTGLFKAQVNAITGRLFNDQKQlDSAFSIQYSYVNIGS 154
Cdd:COG2814 294 GSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEAR-GRASGLYNSAFFLGG 345
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
76-190 |
5.71e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 38.75 E-value: 5.71e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 76 RKIGARYLVPIGLIIMGVGYLVGWKASSAGMINLMIILISIGTGLFKAQVNAITGRLFNDQKqLDSAFSIQYSYVNIGSF 155
Cdd:cd06173 269 KRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDEL-RGRVFSVYNALNSGAMP 347
|
90 100 110
....*....|....*....|....*....|....*
gi 501048328 156 IGTTTIGVLAGSMGYSFCFLICAIMTFIYAVIFIF 190
Cdd:cd06173 348 LGALLAGLLADALGLSAVFLLAGALLLLAALLLLL 382
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
73-190 |
7.41e-03 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 38.33 E-value: 7.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 73 ISDRKIGARYLVPIGLIIMGVGYLVGWKASSAGMINLMIILISIGTGLFKAQVNAITGRlFNDQKQLDSAFSIQYSYVNI 152
Cdd:cd17330 233 RLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSK-SVPSKEQGKAQGIIQSLQSL 311
|
90 100 110
....*....|....*....|....*....|....*...
gi 501048328 153 GSFIGTTTIGVLAGSMGYSFCFLICAIMTFIYAVIFIF 190
Cdd:cd17330 312 ARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFLLSL 349
|
|
| MFS_NPF1_2 |
cd17416 |
NRT1/PTR family (NPF), subfamily 1 and 2 of the Major Facilitator Superfamily of transporters; ... |
47-194 |
8.06e-03 |
|
NRT1/PTR family (NPF), subfamily 1 and 2 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF1 includes Medicago truncatula LATD/NIP, now named MtNPF1.7, which is a high-affinity nitrate transporter and is involved in nodulation and root architecture. NPF2 members are well-established nitrate and glucosinolate transporters, including Arabidopsis nitrate influx and efflux transporters with varied tissue and developmental specificity. Examples are AtNPF2.7, which is expressed in the cortex of mature roots, and AtNPF2.9, which is expressed in root companion cells where it is involved in phloem loading. NPF1/2 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340974 [Multi-domain] Cd Length: 444 Bit Score: 38.40 E-value: 8.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 47 LTPADGAKMSANLVAWTYFAPLIGSYISDRKIGARYLVPIGLIIMGVGYLVGWKASS----------------------- 103
Cdd:cd17416 32 MKSIAAANIINIWSGTTNFLPVVGAFLSDSYFGRFPTISVGSFASLLGMVLLTLTAAipslrpppcetasslcqspsklq 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 104 AGMINLMIILISIGTG-----LFKAQVNAITGRLFNDQKQLDSAFSIQYSYVNIGSFIGTTTIGVLAGSMGYSFCFLICA 178
Cdd:cd17416 112 LAVLYSALALLSIGAGgirpcSLAFGADQFDKKTESGKRGLESFFNWYYFTFTVAQIISLTAIVYIQDNVSWKIGFGIPA 191
|
170
....*....|....*.
gi 501048328 179 IMTFIYAVIFIFGWRF 194
Cdd:cd17416 192 ALMLLSFILFLAGSRL 207
|
|
| MFS_NPF5 |
cd17417 |
NRT1/PTR family (NPF), subfamily 5 of the Major Facilitator Superfamily of transporters; The ... |
20-336 |
9.40e-03 |
|
NRT1/PTR family (NPF), subfamily 5 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF5 includes Arabidopsis thaliana PTR3 (AtPTR3, now named AtNPF5.2), which is a wound-induced peptide transporter that is necessary for defense against virulent bacterial pathogens. NPF5 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340975 [Multi-domain] Cd Length: 452 Bit Score: 38.40 E-value: 9.40e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 20 FERFAFYSakwlitmfVAAKIIN---GGLGLTPADGAKMSANLVAWTYFAPLIGSYISDRKIGaRY---LVPIGLIIMGV 93
Cdd:cd17417 13 AERFAYYG--------IASNLVTyltTPLHQSTARAAKNVNNWSGTATLLPLLGAFVADAYLG-RYrtiLISSLIYLLGL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 94 GYL----------------VGWKASSAGMINLMIIL--ISIGTGLFKAQVNAITGRLFNDQ-----KQLDSAFSIQYSYV 150
Cdd:cd17417 84 VLLtlsaslpslkppecngTCSKASTLQVAFFFFSLylVAIGQGGHKPCVQAFGADQFDEDdpkekKQKSSFFNWWYFSI 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 151 NIGSFIGTTTIGVLAGSMGYSFCFLICAIMTFIYAVIFIFGwrflgdTGKKPFKIDEHKEVkeakqeekkpltkiekkrI 230
Cdd:cd17417 164 CAGSLTAVTVLVYIQDNVGWALGFGIPTIVMALALFVFLLG------TPLYRYKVEEVKLV------------------L 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048328 231 GAIILISFFSIIFWIFWQLaylPVYFYWGGDNGFANwMIGNFKVPTVWFDSLNALCCIVLGPILARVWAKLARRPQGD-- 308
Cdd:cd17417 220 RLIPIWFTTLVFTVVFAQS---PTFFTKQGVTMDRT-IGPNFKIPPASLQSFITLSILISIPIYDRVFVPIARKITGNpr 295
|
330 340
....*....|....*....|....*....
gi 501048328 309 -MSMFKKTALGMLLLGLSYVIFAMADVTR 336
Cdd:cd17417 296 gITLLQRIGIGMFLSILAMVIAALVEMKR 324
|
|
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