|
Name |
Accession |
Description |
Interval |
E-value |
| PTR2 |
COG3104 |
Dipeptide/tripeptide permease [Amino acid transport and metabolism]; |
6-436 |
1.76e-110 |
|
Dipeptide/tripeptide permease [Amino acid transport and metabolism];
Pssm-ID: 442338 [Multi-domain] Cd Length: 479 Bit Score: 334.09 E-value: 1.76e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 6 KRPFGFYVCSIAFTLERFAFYSAKWLLAVFVVAKIADGGLGLSAADAAKMSANLVAFTYAAPLIGAIISDRFIGARYLVP 85
Cdd:COG3104 11 GHPKGLYTLFFTEMWERFSFYGMRAILVLYLTASLADGGLGLSEADAAAIYGAYTALVYLTPLLGGWLADRLLGQRRAIL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 86 IGMVLMGAGYLVGWQASSAGMVNLMIVLVSLGTGLFKCQTNAITGRLF--DDPReLDSAFSIQYSFVNIGSFIGTTIIGV 163
Cdd:COG3104 91 LGGILMALGHFLLALPGGVTLFYLGLALIAVGNGLFKPNISSLVGQLYdpGDPR-RDAGFTIFYMGINIGAFLAPLLCGY 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 164 LVGTKGYAFCFLVCGIMMFIDAAWFTFGWRFLGETGKKPFKIDEH----------------------------------- 208
Cdd:COG3104 170 LGEKYGWHYGFGAAAIGMLIGLIIFLLGRKYLGDIGLEPDNPLSKkerliavalgalllvlvlagllsnanianyllyvi 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 209 KEVKAKETKEEKKPLTSIEKKRVAAIILVSFFSVIFWVFWYLAYMPVYFYWggdNAAANWMIGNFQVPTAWFDSLNALAC 288
Cdd:COG3104 250 AIIAYFIFILRSKKLTKEERKRLLAILILFLFSIVFWALYEQAGTSLNLFA---DRNVDRSLFGFEIPPSWFQSLNPLFI 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 289 ISLGPILGKVWSKLAKRpQGDLSMFKKTALGMILLGLSYVIFAMADVTRG-GNLAPLAWIIAFGIVLSLGEMVFSPLGNS 367
Cdd:COG3104 327 IILAPVFAALWTKLGKR-GKEPSTPTKFALGLLLLGLGFLVMALAALLAGaGGKVSPLWLVLAYLLLTIGELCLSPVGLS 405
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 501048329 368 FISKFSPPKLLSSMMSVWVLAVFFAAKSYGWVYEFTLKFKFAPTYFAIAAIAAGAGVILWLLDGKLNSL 436
Cdd:COG3104 406 MITKLAPARFAGQMMGLWFLATALGNLLAGLLAGLYAVPGYTAYFLLLGGIALVAGVVLLLLSPKLRRL 474
|
|
| MFS_DtpA_like |
cd17346 |
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily ... |
8-432 |
2.57e-101 |
|
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily of transporters; The DtpA-like subfamily includes four Escherichia coli proteins: dipeptide and tripeptide permeases A (DtpA, TppB or YdgR), B (DtpB or YhiP), C (DtpC or YjdL), and D (DtpD or YbgH). They are proton-dependent permeases that transport di- and tripeptides. DtpA and DtpB display a preference for di- and tripeptides composed of L-amino acids. DtpC shows higher specificity for dipeptides compared to tripeptides, and prefers dipeptides containing a C-terminal lysine residue. The DtpA-like subfamily belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340904 [Multi-domain] Cd Length: 399 Bit Score: 307.96 E-value: 2.57e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 8 PFGFYVCSIAFTLERFAFYSAKWLLAVFVVAKIADGglgLSAADAAKMSANLVAFTYAAPLIGAIISDRFIGARYLVPIG 87
Cdd:cd17346 1 PKGLYTLFFTEMWERFSYYGMRAILILYLTAQLGDG---FSEADAASIYGAYTALVYLTPIIGGWLADKVLGARRTVFIG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 88 MVLMGAGYLV-GWQASSAGMVNLMIVLVSLGTGLFKCQTNAITGRLFDDPRE-LDSAFSIQYSFVNIGSFIGTTIIGVLV 165
Cdd:cd17346 78 GILMALGYLLlALSPFSVSMLYLGLALIIVGNGLFKPNISSLVGKLYDENDPrRDSGFSIFYMGINLGAFLAPLLCGTLG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 166 GTKGYAFCFLVCGIMMFIDAAWFTFGWRFLGEtgkkpfkidehkevkaketkeekkpltsieKKRVAAIILVSFFSVIFW 245
Cdd:cd17346 158 DNYGYHYGFGLAAVGMLLGLLIFLLGRKKLLE------------------------------RKKMLAIIILFLFAVVFW 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 246 VFWYLAYMPVYFYWGGDnaaANWMIGNFQVPTAWFDSLNALACISLGPILGKVWSKLAKRpQGDLSMFKKTALGMILLGL 325
Cdd:cd17346 208 AIYEQAGTSLALFADEN---VDRLLGGFTIPPSWFQSLNPLFIILLAPILAALWTKLGKR-GKDPSIPTKFALGLLLLGL 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 326 SYVIFAMADVTRGGN-LAPLAWIIAFGIVLSLGEMVFSPLGNSFISKFSPPKLLSSMMSVWVLAVFFAAKSYGWVYEFTL 404
Cdd:cd17346 284 SFLLMVLAASFAGGSgKVSALWLVLSYFLQTLGELCLSPVGLSMITKLAPAKFAGFMMGLWFLASALGNILAGYLAGFYA 363
|
410 420 430
....*....|....*....|....*....|....*.
gi 501048329 405 --------KFKFAPTYFAIAAIAAGAGVILWLLDGK 432
Cdd:cd17346 364 qpkdplasALVYTDYFGLIGVIALVAGIILLLLAKK 399
|
|
| yjdL_sub1_fam |
TIGR00924 |
amino acid/peptide transporter (Peptide:H+ symporter), bacterial; The model describes ... |
8-437 |
5.78e-39 |
|
amino acid/peptide transporter (Peptide:H+ symporter), bacterial; The model describes proton-dependent oligopeptide transporters in bacteria. This model is restricted in its range in recognizing bacterial proton-dependent oligopeptide transporters, although they are found in yeast, plants and animals. They function by proton symport in a 1:1 stoichiometry, which is variable in different species. All of them are predicted to contain 12 transmembrane domains, for which limited experimental evidence exists. [Transport and binding proteins, Amino acids, peptides and amines]
Pssm-ID: 273342 [Multi-domain] Cd Length: 475 Bit Score: 146.52 E-value: 5.78e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 8 PFGFYVCSIAFTLERFAFYSAKWLLAVFVVAKiadGGLGLSAADAAKMSANLVAFTYAAPLIGAIISDRFIGARYLVPIG 87
Cdd:TIGR00924 9 PKPLFTLFFVELWERFSYYGMQGILAVYLVQQ---AGLGFSQEQAFIIFGAYSALVYLLTSVGWWFGDRVWGTKKTMVLG 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 88 MVLMGAGYLVGWQASSAGMVNLMIVLVSLGTGLFKCQTNAITGRLF---DDPReLDSAFSIQYSFVNIGSFIGTTIIGVL 164
Cdd:TIGR00924 86 GIVLMLGHFMLAMSIYPDLIFYGLGTIAVGSGLFKANPSSMVGKLYergDMPR-RDGGFTLFYMSINIGSFISPLLAGVI 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 165 VGTKGYAFCFLVCGIMMFIDAAWFTFGWRFLGETGKKPFKIDEHKEVKAKETK--------------------------- 217
Cdd:TIGR00924 165 AENYGYHVGFNLAAVGMVIGLLTFFAGRHMLRDIGSVPDPLSGQGKTYGKLLLallaalalvffcawlmhhvvianillm 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 218 -------------EEKKPLTSIEKKRVAAIILVSFFSVIFWVFWYLAYMPVYFYwgGDNAAANWMIGnFQVPTAWFDSLN 284
Cdd:TIGR00924 245 tvtlaviifffrlAFKPRLDAVARNKMYAYIVLFLEAVVFWVLYAQMPTSLNFF--ADNNMHHEMLG-MSVPVIWFQSLN 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 285 ALACISLGPILGKVWSKLAKRPQgDLSMFKKTALGMILLGLSYVIF-AMADVTRGGNLAPLAWIIAFGIVLSLGEMVFSP 363
Cdd:TIGR00924 322 PFWVVVGSPVLAMIWTRLGRKGK-DPTTPLKFTLGMLFCGASFLTFaASIWFADAGGLTSPWFMVLIYLFQTLGELMISP 400
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 501048329 364 LGNSFISKFSPPKLLSSMMSVWVLAVFFAAKSYGWVYEFTLKFKFAPTYFAIAAIAAGAG-VILWLLDGKLNSLV 437
Cdd:TIGR00924 401 LGLSWWTKIAPQRLMGQMLGMWFLAQAMGSLLGGYLATFGAVPQGVTGVFGKIGLVTLLVgVVMALMVPWLNRMM 475
|
|
| PTR2 |
pfam00854 |
POT family; The POT (proton-dependent oligopeptide transport) family all appear to be proton ... |
86-387 |
3.01e-25 |
|
POT family; The POT (proton-dependent oligopeptide transport) family all appear to be proton dependent transporters.
Pssm-ID: 425909 [Multi-domain] Cd Length: 392 Bit Score: 106.63 E-value: 3.01e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 86 IGMVLMGAGYLVGWQASSAGMVNLM-IVLVSLGTGLFKCQTNAITGRLFD--DPRELDSAFSIQYSFVNIGSFIGTTIIG 162
Cdd:pfam00854 13 IGHILLALSAIPSLRPPVHVALFFIgLALIALGTGGIKPNVSSFGGDQFEetDPRRRSRFFSIFYFSINAGSLISTIITP 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 163 VLVGTKGYAFCFLVCGIMMFIDAAWFTFGWRFLGETGKKP--------------------------FKIDEH-------- 208
Cdd:pfam00854 93 YLQQNYGYPLGFGLPAVGMIIALLVFLLGSRMYKKKPPKGnvltkvfkvlpvaawnkvklngssagIKKLHWldwareld 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 209 -----KEVKAKETKEEKKPLTSIE-KKRVAAIILVSFFSVIFWVFWylAYMPVYFywggdNAAANWM---IGNFQVPTAW 279
Cdd:pfam00854 173 aliilGIVVPGIFFNIWCTKTKVEeVKRLLRVLPLFLPLIMFWALY--DQMGTSW-----VLQARTMnrkIGSFEIPPAQ 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 280 FDSLNALACISLGPILGKVWSKLAKRPQGDLSMFKKTALGMILLGLSYVIFAMADVTR----------GGNLAPLAWIIA 349
Cdd:pfam00854 246 FQAFNAILVLIFIPIFDRLVYPLGRKCTGGLTPLQKMAVGLFLASLAFAIAAIVQLKRndtgpefpiaQEVPISVLWLIP 325
|
330 340 350
....*....|....*....|....*....|....*...
gi 501048329 350 FGIVLSLGEMVFSPLGNSFISKFSPPKLLSSMMSVWVL 387
Cdd:pfam00854 326 QYLLIGFGELFISIGGLEFFYKLAPKSMTSLITGLFLL 363
|
|
| tppB |
PRK09584 |
dipeptide/tripeptide permease DtpA; |
3-399 |
1.09e-23 |
|
dipeptide/tripeptide permease DtpA;
Pssm-ID: 181969 Cd Length: 500 Bit Score: 103.30 E-value: 1.09e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 3 NTNKRPFGFY-VCSIAFtLERFAFYSAKWLLAVFVVAKiadggLGLSAADAAKMSANLVAFTYAAPLIGAIISDRFIGAR 81
Cdd:PRK09584 15 NAFKQPKAFYlIFSIEL-WERFGYYGLQGIMAVYLVKQ-----LGMSEADSITLFSSFSALVYGLVAIGGWLGDKVLGTK 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 82 YLVPIGMVLMGAGY-LVGWQASSAGMVNLMIVLVSLGTGLFKCQTNAITGRLF--DDPReLDSAFSIQYSFVNIGSFIGT 158
Cdd:PRK09584 89 RVIMLGAIVLAIGYaLVAWSGHDAGIVYMGMATIAVGNGLFKANPSSLLSTCYekDDPR-LDGAFTMYYMSINIGSFFSM 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 159 TIIGVLVGTKGYAFCFLVCGIMMFIDAAWFTFGWRFLGETGKKPFKIDEHKEVKAKETKEEKK----------------- 221
Cdd:PRK09584 168 LATPWLAAKYGWSVAFALSVVGMLITVVNFAFCQRWVKQYGSKPDFEPINYRKLLLTIVGVVAliaiatwllhnqeiarm 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 222 ------------------PLTSIEKKRVAAIILVSFFSVIFWVFWYlaYMPVYFYWGGDNAAANWMIGnFQVPTAWFDSL 283
Cdd:PRK09584 248 algvvalgivvifgkeafAMKGAARRKMIVAFILMLEAIIFFVLYS--QMPTSLNFFAIRNVEHSILG-IAVEPEQYQAL 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 284 NALACISLGPILGKVWSKLAKRpqgdLSMFKKTALGMILLGLSYVIFAM-ADVTRGGNLAPLAWIIAFGIVLSLGEMVFS 362
Cdd:PRK09584 325 NPFWIMIGSPILAAIYNKMGDR----LPMPHKFAIGMVLCSGAFLVLPLgAKFANDAGIVSVNWLIASYGLQSIGELMIS 400
|
410 420 430
....*....|....*....|....*....|....*..
gi 501048329 363 PLGNSFISKFSPPKLLSSMMSVWVLAVFFAAKSYGWV 399
Cdd:PRK09584 401 GLGLAMVAQLVPQRLMGFIMGSWFLTTAGAALIAGYV 437
|
|
| MFS_POT |
cd06175 |
Proton-coupled oligopeptide transporter (POT) family of the Major Facilitator Superfamily of ... |
20-391 |
1.96e-16 |
|
Proton-coupled oligopeptide transporter (POT) family of the Major Facilitator Superfamily of transporters; The Proton-coupled oligopeptide transporter (POT) family is present across all major kingdoms of life and is known by a variety of names. It is referred to as the Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) in plants, and in addition to POT, it is also known as the Peptide transporter (PepT/PTR) or Solute Carrier 15 (SLC15) family in animals. Members of this family are proton-driven symporters involved in nitrogen acquisition in the form of di- and tripeptides. Plant members transport other nitrogenous ligands including nitrate, the plant hormone auxin, and glucosinolate compounds that are important for seed defense. POT proteins exhibit substrate multispecificity, with one transporter able to recognize as many as 8,400 types of di/tripeptides and certain peptide-like drugs. The POT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340865 [Multi-domain] Cd Length: 422 Bit Score: 80.94 E-value: 1.96e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 20 LERFAFYSAKWLLAVFVVakiadGGLGLSAADAAKMSANLVAFTYAAPLIGAIISDRFIGARYLVPIGMVLMGAGYLV-- 97
Cdd:cd06175 10 CERFTFYGIGANLVPFLT-----GALGLGNAQAANVVLNFLGTSYVTPLFGGWIADTFLGRYRTILIGAAIYAVGVAIlt 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 98 ----------------GWQASSAGMVNLM---IVLVSLGTGLFKCQTNAITGRLFD--DPRELDSAFSIQYSFVNIGSFI 156
Cdd:cd06175 85 vstippglrplrcnpsHCEQASGIQLTGFyaaLYLIALGTGGVKANVSPLGADQFDerGPSKTQSFFNWFYFCINVGSLL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 157 GTTIIGVLVGTKGYAFCFLVCGIMMFIdaawftfgwrflgetgkkpfkidehkevkaketkeekkPLTSIEKKRVAAIIL 236
Cdd:cd06175 165 AMLGTPYIQDNVGWAAAYGIPFVAILL--------------------------------------ALVVFEVKQLLRALP 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 237 VSFFSVIFWVFWylAYMPVYFYWGGDNAAANwmIGNFQVPTAWFDSLNALACISLGPILGKVWSKLAKRPQGDLSMFKKT 316
Cdd:cd06175 207 LFAFCILFWTVY--AQMTTSYVLQALTLVRS--TGLFTIPPASMQAFNPILLLLLIPVLDKVVYPLIRRYGVGLSPLTKI 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 317 ALGMILLGLSYVIFAMAD-----------VTRGGNLAPLAWIIAFGIVLSLGEMVFSPLGNSFISKFSPPKLLSSMMSVW 385
Cdd:cd06175 283 GLGFFFGSLSMFVAGFLElkrlntahahgPVVTTSPLSFWWQIPQYLLLGIGEILVSITGLEFAYREAPKSMKGFIMGLL 362
|
....*.
gi 501048329 386 VLAVFF 391
Cdd:cd06175 363 LLTSGF 368
|
|
| PRK15462 |
PRK15462 |
dipeptide permease; |
1-387 |
2.48e-15 |
|
dipeptide permease;
Pssm-ID: 237971 [Multi-domain] Cd Length: 493 Bit Score: 78.07 E-value: 2.48e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 1 MENTNKRPFGFYVCSIAFTLERFAFYSAKWLLAVFVVAKiadggLGLSAADAAKMSANLVAFTYAAPLIGAIISDRFIGA 80
Cdd:PRK15462 1 MNKHASQPRAIYYVVALQIWEYFSFYGMRALLILYLTNQ-----LKYDDNHAYELFSAYCSLVYVTPILGGFLADKVLGN 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 81 RYLVPIGMVLMGAGYLV-GWQASSAGMVNLMIVLVSLGTGLFKCQTNAITGRLF--DDPRElDSAFSIQYSFVNIGSFIG 157
Cdd:PRK15462 76 RMAVMLGALLMAIGHVVlGASEIHPSFLYLSLAIIVCGYGLFKSNVSCLLGELYepTDPRR-DGGFSLMYAAGNVGSIIA 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 158 TTIIGVLVGTKGYAFCFLVCGIMMFIDAAWFTFGWRFLGETG-------------------------KKPFKI------D 206
Cdd:PRK15462 155 PIACGYAQEEYSWAMGFGLAAVGMIAGLVIFLCGNRHFTHTRgvnkkvlratnfllpnwgwllvllvATPALItvlfwkE 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 207 EHKEVKAKETKEEKKPLTSI--------EKKRVAAIILVSFFSVIFWVFWYLAYMPVYFYWggdNAAANWMIGNFQVPTA 278
Cdd:PRK15462 235 WSVYALIVATIIGLGVLAKIyrkaenqkQRKELGLIVTLTFFSMLFWAFAQQGGSSISLYI---DRFVNRDMFGYTVPTA 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 279 WFDSLNALACISLGPILGkvWskLAKRPQG---DLSMFKKTALGMILLGLSYVIFAMA---DVTRGGNLAPLawIIAFGI 352
Cdd:PRK15462 312 MFQSINAFAVMLCGVFLA--W--VVKESVAgnrTVRIWGKFALGLGLMSAGFCILTLSarwSAMYGHSSLPL--MVLGLA 385
|
410 420 430
....*....|....*....|....*....|....*
gi 501048329 353 VLSLGEMVFSPLGNSFISKFSPPKLLSSMMSVWVL 387
Cdd:PRK15462 386 VMGFAELFIDPVAMSQITRIEIPGVTGVLTGIYML 420
|
|
| PRK10207 |
PRK10207 |
dipeptide/tripeptide permease DtpB; |
21-403 |
6.40e-15 |
|
dipeptide/tripeptide permease DtpB;
Pssm-ID: 182306 Cd Length: 489 Bit Score: 76.78 E-value: 6.40e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 21 ERFAFYSAKWLLAVFVVAKiadggLGLSAADAAKMSANLVAFTYAAPLIGAIISDRFIGARYLVPIGMVLMGAGY-LVGW 99
Cdd:PRK10207 26 ERFGYYGVQGILAVFFVKQ-----LGFSQEQAFITFGAFAALVYGLISIGGYVGDHLLGTKRTIVLGAIVLAIGYfMTGM 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 100 QASSAGMVNLMIVLVSLGTGLFKCQTNAITGRLF--DDPReLDSAFSIQYSFVNIGSFIGTTIIGVLVGTKGYAFCFLVC 177
Cdd:PRK10207 101 SLLKPDLIFIALGTIAVGNGLFKANPASLLSKCYppKDPR-LDGAFTLFYMSINIGSLISLSLAPVIADKFGYSVTYNLC 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 178 GIMMFIdAAWFTFGWRFL-----GETGKKPFKIDEHKEVKAKETKEEKKPLTSIEKKRVAAIILVSFFSVIFWVFWYLAY 252
Cdd:PRK10207 180 GAGLII-ALLVYFACRGMvkdigSEPDHKPMSFSKLLLVLLGSVVMIFVCAWLMHNVEVANLVLIVLSIVVTIIFFREAF 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 253 -----------------------------MPVYFYWGGDNAAANWMIGnFQVPTAWFDSLNALACISLGPILGKVWSKLA 303
Cdd:PRK10207 259 kldktgrnkmfvafvlmleavvfyilyaqMPTSLNFFAINNVHHEILG-FSINPVSFQALNPFWVVVASPILAGIYTHLG 337
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 304 KRPQgDLSMFKKTALGMILLGLSYVIFAMADV--TRGGNLAPLAWIIAFGIVLSLGEMVFSPLGNSFISKFSPPKLLSSM 381
Cdd:PRK10207 338 SKGK-DLSMPMKFTLGMFLCSLGFLTAAAAGMwfADAQGLTSPWFIVLVYLFQSLGELFISALGLAMIAALVPQHLMGFI 416
|
410 420
....*....|....*....|..
gi 501048329 382 MSVWVLAVFFAAKSYGWVYEFT 403
Cdd:PRK10207 417 LGMWFLTQAAAFLLGGYVATFT 438
|
|
| MFS_SLC15A1_2_like |
cd17347 |
Solute carrier family 15 members 1 and 2, and similar Major Facilitator Superfamily ... |
21-391 |
1.93e-14 |
|
Solute carrier family 15 members 1 and 2, and similar Major Facilitator Superfamily transporters; Solute carrier family 15 member 1 (SLC15A1) and SLC15A2 are members of the proton-coupled oligopeptide transporter (POT) family of integral membrane proteins that mediate the cellular uptake of di/tripeptides and peptide-like drugs. They mediate the proton-coupled active transport of a broad range of dipeptides and tripeptides, including zwitterionic, anionic and cationic peptides, as well as a variety of peptide-like drugs such as cefadroxil, enalapril, and valacyclovir. SLC15A1, or peptide transporter 1 (PepT1), is primarily expressed in the brush border membranes of enterocytes of the small intestine and is also known as the intestinal isoform. SLC15A2, or peptide transporter 2 (PepT2), is abundantly expressed in the apical membrane of kidney proximal tubules and is also referred to as the renal isoform. Both proteins transport di/tripeptides, but not tetrapeptides or free amino acids, using the energy generated by an inwardly directed transmembrane proton gradient. The SLC15A1/SLC15A2-like group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340905 [Multi-domain] Cd Length: 427 Bit Score: 74.96 E-value: 1.93e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 21 ERFAFYSAKWLLAVFVVAKiadggLGLSAADAAKMSANLVAFTYAAPLIGAIISDRFIGaRYLV--------PIGMVLMG 92
Cdd:cd17347 14 ERFSYYGMRAILVLYLTDF-----LGFSEAEATAIYHSFVMLCYFFPLLGAIIADSYLG-KYRTilylslvyCLGHIVLA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 93 AGYLVGWQASSAGMVNLMIVLVSLGTGLFK-CQTnAITGRLFDDP--RELDSAFSIQYSFVNIGSFIGTTIIGVL----- 164
Cdd:cd17347 88 VTAIPPLGPPHVWGLLIGLLLIAIGTGGIKpCVS-AFGGDQFGADqqHLLARFFSWFYFAINAGSLLSTFLTPILradvq 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 165 -VGTKGYAFCFLVCGIMMFIdaAWFTFgWRflgetGKKPFKidehkevkaketkeekkpltsiEKKRVAAIILVSFFSVI 243
Cdd:cd17347 167 fGGHDCYPLAFGVPGVLMAV--ATLVF-WL-----GRKHYK----------------------DVKALLRVLVLFIPLPV 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 244 FWVF-------WYLAYmpvyfywggdnAAANWMIGNFQVPTAWFDSLNALACISLGPILGKVWSKLAKRPQGDLSMFKKT 316
Cdd:cd17347 217 FWALfdqqgsrWTLQA-----------EQMDGLVGGFTILPDQMQALNPILILILIPLFDYVIYPLLERCGIPLTPLRKM 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 317 ALGMILLGLSYVIFA--------MADVTRGGNLA-----------PLAWIIAFGIVLSLGEMVFSPLGNSFISKFSPPKL 377
Cdd:cd17347 286 GVGMILAALAFVIAGflqlridgGLPGQPDPGEVttfediepnsvSILWQLPQYVVLTAGEVLFSITGLEFAYTQAPKSM 365
|
410
....*....|....
gi 501048329 378 LSSMMSVWVLAVFF 391
Cdd:cd17347 366 KSVVQAAWLLTVAL 379
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
44-384 |
3.35e-12 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 67.64 E-value: 3.35e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 44 GLGLSAADAAKMSANLVAFtyAAPLIGAIISDRFiGARYLVPIGMVLMGAGYLVGWQASSAGMVNLMIVLVSLGTGLFKC 123
Cdd:cd17329 31 GLSASIVGLVLALSAVAGI--VASLIGGRLADRF-GRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEP 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 124 QTNAITGRLFDdPRELDSAFSIQYSFVNIGSFIGTTIIGVLVGTkGYAFCFLVCGIMMFIDAAWFtfgWRFLGETGKKPF 203
Cdd:cd17329 108 ASEAMIADVTT-PENRTRAFSLLYWAINLGVAIGPLLGGLLLLY-SFRLLFLAAAVLFLLAALVL---LFLLPETRPKRR 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 204 KIDEHKEVKaketkeekkPLTSIEKKRVAAIILVSFFSVIFWVFWYLAYMPVYfywggdnaaANWMIGNFQVPTAWFDSL 283
Cdd:cd17329 183 AAEKTEILR---------GYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVY---------VVEILGLGESLLGLLLAL 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 284 NALACISLGPILGKVWSKLAKRPQGdlsmfkktALGMILLGLSYVIFAMADVtrggnlapLAWIIAFGIVLSLGEMVFSP 363
Cdd:cd17329 245 NALLIVLLQFPVARLVERFRLRKIL--------MIGILLFAIGFAVLAFANT--------LAVLILAMIVLTLGEMLVFP 308
|
330 340
....*....|....*....|.
gi 501048329 364 LGNSFISKFSPPKLLSSMMSV 384
Cdd:cd17329 309 AVQTLVAALAPPDKRGSYMGF 329
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
55-394 |
1.90e-11 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 65.00 E-value: 1.90e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 55 MSANLVAFTYAAPLIGAIiSDRFiGARYLVPIGMVLMGAGYLVGWQASSAGMVNLMIVLVSLGTGLFKCQTNAITGRLFD 134
Cdd:COG2814 51 VTAYLLGAALGAPLAGRL-ADRF-GRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVP 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 135 dPRELDSAFSIQYSFVNIGSFIGTTIIGVLVGTKGYAFCFLVCGIMMFIDAAWFTFGWRFLGETGKKPFKidehkevkak 214
Cdd:COG2814 129 -PERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLR---------- 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 215 etkeekKPLTSIEKKRVAAIILVSFFSVIFWVFWYLAYMPVYF--YWGGDNAAANWMIGnfqvptawfdsLNALACISLG 292
Cdd:COG2814 198 ------GSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLqeVLGLSASAAGLLLA-----------LFGLGGVLGA 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 293 PILGkvwsKLAKRpqgdLSMFKKTALGMILLGLSYVIFAMADvtrggnlaPLAWIIAFGIVLSLGEMVFSPLGNSFISKF 372
Cdd:COG2814 261 LLAG----RLADR----FGRRRLLLIGLLLLALGLLLLALAG--------SLWLLLLALFLLGFGFGLLFPLLQALVAEL 324
|
330 340
....*....|....*....|..
gi 501048329 373 SPPKLLSSMMSVWVLAVFFAAK 394
Cdd:COG2814 325 APPEARGRASGLYNSAFFLGGP 346
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
23-393 |
2.24e-09 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 58.58 E-value: 2.24e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 23 FAFYSAKWLLAVFVVAKIADGgLGLSAADAAKMSANLVAFTYAAPLIGAIISDRFiGARYLVPIGMVLMGAGYLVGWQAS 102
Cdd:pfam07690 6 FLAALGRSLLGPALPLLLAED-LGISPTEIGLLLTLFSLGYALAQPLAGRLSDRF-GRRRVLLIGLLLFALGLLLLLFAS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 103 SAGMVNLMIVLVSLGTGLFKCQTNAITGRLFDdPRELDSAFSIQYSFVNIGSFIGTTIIGVLVGTKGYAFCFLVCGIMMF 182
Cdd:pfam07690 84 SLWLLLVLRVLQGLGAGALFPAALALIADWFP-PEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 183 IdaaWFTFGWRFLGETGKKPFKIDEHKEVKAKEtkeekkpLTSIEKKRVAAIILVSFFSVIFWVFWYLAYMPVYFYWGGD 262
Cdd:pfam07690 163 L---AAVLLLLPRPPPESKRPKPAEEARLSLIV-------AWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 263 NAAANWMIGnfqvptawfdSLNALACISLGPILGKVWSKLAKRPQgdlsmfkkTALGMILLGLSYVIFAMAdvtrgGNLA 342
Cdd:pfam07690 233 SALLAGLLL----------GLGGLLGAIGRLLLGRLSDRLGRRRR--------LLLALLLLILAALGLLLL-----SLTL 289
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 501048329 343 PLAWIIAFGIVLSLGEMVFSPLGNSFISKFSPPKLLSSMMSVWVLAVFFAA 393
Cdd:pfam07690 290 SSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGG 340
|
|
| MFS_SLC15A1 |
cd17412 |
Solute Carrier family 15 member 1 of the Major Facilitator Superfamily of transporters; Solute ... |
21-389 |
3.38e-09 |
|
Solute Carrier family 15 member 1 of the Major Facilitator Superfamily of transporters; Solute carrier family 15 member 1 (SLC15A1), also called peptide transporter 1 (PepT1), is a member of the proton-coupled oligopeptide transporter (POT) family of integral membrane proteins that mediate the cellular uptake of di/tripeptides and peptide-like drugs. SLC15A1, as well as SLC15A2, mediate the proton-coupled active transport of a broad range of dipeptides and tripeptides, including zwitterionic, anionic and cationic peptides, as well as a variety of peptide-like drugs such as cefadroxil, enalapril, and valacyclovir. SLC15A1 is primarily expressed in the brush border membranes of enterocytes of the small intestine and is also known as the intestinal isoform. It is a high-capacity/low-affinity transporter that drives the transport of di-and tripeptides for metabolic purposes. It's expression is upregulated in the colon during chronic inflammation associated with inflammatory bowel disease. SLC15A1/PepT1 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340970 [Multi-domain] Cd Length: 415 Bit Score: 58.70 E-value: 3.38e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 21 ERFAFYSAKWLLAVFVVAKiadggLGLSAADAAKMSANLVAFTYAAPLIGAIISDRFIGA-RYLVPIGMVlmgagYLVGW 99
Cdd:cd17412 14 ERFSYYGMRAVLVLYFKYF-----LRWDDDLSTAIYHTFVALCYLTPILGAIIADSWLGKfKTIVYLSIV-----YTIGQ 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 100 QASSAGMVNLM----------------------IVLVSLGTGLFKCQTNAITGRLFDDPRELDSA--FSIQYSFVNIGSF 155
Cdd:cd17412 84 AVMAVSAIHDLtdanrdgtpdnltlhvalsmigLLLIALGTGGIKPCVAAFGGDQFEEHQEKQRSrfFSIFYLSINAGSL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 156 IGTTIIGVLVGT--------KGYAFCFLVCGIMMFIDAAWFTFGwrflgetgkkpfkidehkevkaketkeekkpltSIE 227
Cdd:cd17412 164 LSTIITPILRSQecgihskqKCYPLAFGVPAALMVVALIVFILG---------------------------------SKM 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 228 KKRVAAIILVSFFSVIFWVFWYLAympvyfywggDNAAANW------MIGNF---QVPTAWFDSLNALACISLGPILGKV 298
Cdd:cd17412 211 YKQIKMVLKVLFLYIPLPMFWALF----------DQQGSRWtlqattMDGNFgaiQIQPDQMQTVNPILIIIMVPIFDAV 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 299 WSKLAKRPQGDLSMFKKTALGMILLGLSYVIFAMADVTrggnlapLAWIIAFGIVLSLGEMVFSPLGNSFISKFSPPKLL 378
Cdd:cd17412 281 IYPLIKKCKINFTPLRKMTVGMFLAALAFVAAALLQIQ-------MAWQIPQYFLLTCGEVVFSVTGLEFSYSQAPSNMK 353
|
410
....*....|.
gi 501048329 379 SSMMSVWVLAV 389
Cdd:cd17412 354 SVLQAGWLLTV 364
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
23-193 |
6.25e-09 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 57.57 E-value: 6.25e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 23 FAFYSAKWLLAVFVVAKIADGgLGLSAADAAKMSANLVAFTYAAPLIGAIISDRFI-GARYLVPIGMVLMGAGYLVGWQA 101
Cdd:COG2271 190 FLVYFALYGFLTWLPTYLVEV-RGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGrRRKLVLAIGLLLAALALLLLALL 268
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 102 SSAGMVNLMIVLVSLGTGLFKCQTNAITGRLFDdPRELDSAFSIQYSFVNIGSFIGTTIIGVLVGTKGYAFCFLVCGIMM 181
Cdd:COG2271 269 PSPALAIALLFLAGFGLGGAFGLLWALAAELFP-KKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALA 347
|
170
....*....|..
gi 501048329 182 FIDAAWFTFGWR 193
Cdd:COG2271 348 LLAALLALLLLR 359
|
|
| MFS_PTR2 |
cd17350 |
Peptide transporter PTR2 of the Major Facilitator Superfamily of transporters; Fungal peptide ... |
11-393 |
6.10e-07 |
|
Peptide transporter PTR2 of the Major Facilitator Superfamily of transporters; Fungal peptide transporter or permease PTR2 is a member of the proton-coupled oligopeptide transporter (POT) family of integral membrane proteins that mediate the cellular uptake of di/tripeptides and peptide-like drugs. It is a 12-transmembrane domain (TMD) integral membrane protein that translocates di-/tripeptides. As with other POT family proteins, it displays characteristic substrate multispecificity. PTR2 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340908 [Multi-domain] Cd Length: 438 Bit Score: 51.31 E-value: 6.10e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 11 FYVCSIAFTlERFAFYSAKWLLAVFVVAKIAD---GGLGLSAADAAKMSANLVAFTYAAPLIGAIISDRFIGARYLVPIG 87
Cdd:cd17350 5 FLIAIVELC-ERFSYYGLTGPFQNYMQFGPDDstpGALGLGEQGATGLSNFFTFWCYVTPVIGAYVADQFLGRYNTIVCG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 88 MVLMGAGYL---------VGWQASSAGMVNLMIVLVSLGTGLFKCQTNAI----------------TGR--LFDDPRELD 140
Cdd:cd17350 84 AVIYFVGILiltctsipsVIDAGAGLGGFVVAIIIIGLGTGGIKSNVSPLiadqlpkikpyvktlkNGErvIVDPVVTLS 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 141 SAFSIQYSFVNIGSF--IGTTiigVLVGTKGYAFCFLVCGIMMFIDAAWFTFGWRFLGETGKKpfKIDehkevkaketke 218
Cdd:cd17350 164 RIYMIFYWAINVGSLslLATT---YLERTKGFWYAYLLPLCVFVIPLIILAFGKKFYKIRPDL--FID------------ 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 219 ekkpltsiEKKRVAAIILVSFFSVIFWVfwylaympVYFYWGGDNAAANWMIGNFQVPTAWFDSLNALACISLGPILGKV 298
Cdd:cd17350 227 --------ELKRALRACKVFLFYPIYWV--------CYGQMTSNFISQAGQMQLHGVPNDLFQAFDSIALIIFIPILENI 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 299 WSKLAKRPQGDLSMFKKTALGMILLGLSYVIFAM--------------ADVTRGGNLAPLAWIIAFGIVLSLGEMVFSPL 364
Cdd:cd17350 291 IYPLLRKYNIPFKPITRITLGFMFASFSMIYAAVlqakiyqagpcyanPTGTCSPNDIHVWIQIPAYVLIAFSEIFASIT 370
|
410 420
....*....|....*....|....*....
gi 501048329 365 GNSFISKFSPPKLLSSMMSVWVLAVFFAA 393
Cdd:cd17350 371 GLEYAYTKAPPSMKSFITALFLLTNAFGA 399
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
55-191 |
7.18e-07 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 51.04 E-value: 7.18e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 55 MSANLVAFTYAAPLIGAIiSDRFiGARYLVPIGMVLMGAGYLVGWQASSAGMVNLMIVLVSLGTGLFKCQTNAITGRLFD 134
Cdd:cd17325 241 FGAQGLASALSQPPAGKL-SDRI-GRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVP 318
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 501048329 135 dPRELDSAFSIQYSFVNIGSFIGTTIIGVLVGTKGYAFCFLVCGIMMFIDAAWFTFG 191
Cdd:cd17325 319 -PEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLL 374
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
67-370 |
9.99e-07 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 50.67 E-value: 9.99e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 67 PLIGAIiSDRF---IGAR--YLVpIGMVLMGAGYLVGWQASSAGMVNLMI------VLVSLGTGLFKCQTNAITGRLFDD 135
Cdd:COG2211 64 PLIGAL-SDRTrtrWGRRrpWIL-IGAIPLALSFVLLFTAPDLSPTGKLIyalvtyLLLGLAYTLVNIPYSALGAELTPD 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 136 PRELDSAFSIQYSFVNIGSFIGTTIIGVLVGT------KGYAFCFLVCGIMMFIDAAWFTFGW--RFLGETGKKPFKIDe 207
Cdd:COG2211 142 YEERTRLSSWRFAFAGLGGLLASVLPPPLVAAfggdaaLGYRLTALIFAVLGLLAFLLTFFGTkeRPVPEEEKVSLKES- 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 208 hkevkaketkeekkpLTSIEKKRVAAIILVSFFSVIFWVFWYLAYMPVYF--YWGGDNAAANWMIGNFQVPtawfdslnA 285
Cdd:COG2211 221 ---------------LKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFkyVLGLSAALVGLLLALYFLA--------A 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 286 LACISLGPILGKVWSKlakrpqgdlsmfKKT-ALGMILLGLSYVIFAMADVTrggnlaPLAWIIAFGIVLSLGEMVFSPL 364
Cdd:COG2211 278 LLGAPLWPRLAKRFGK------------KKAfIIGLLLAALGLLLLFFLGPG------NLWLLLVLAALAGIGLGAILVL 339
|
....*.
gi 501048329 365 GNSFIS 370
Cdd:COG2211 340 PWAMLA 345
|
|
| MFS_NPF7 |
cd17419 |
NRT1/PTR family (NPF), subfamily 7 of the Major Facilitator Superfamily of transporters; The ... |
45-337 |
1.54e-06 |
|
NRT1/PTR family (NPF), subfamily 7 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF7 includes the nitrate transporters AtNPF7.2 and AtNPF7.3, as well as the dipeptide transporter OsNPF7.3. AtNPF7.3 is a bidirectional transporter involved in nitrate influx and efflux. NPF7 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340977 [Multi-domain] Cd Length: 447 Bit Score: 50.07 E-value: 1.54e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 45 LGLSAADAAKMSANLVAFTYAAPLIGAIISDRFIGaRYLVP--------IGMVLM--------------GAGYLVGWQAS 102
Cdd:cd17419 33 MHQSNASAANNVSNWTGTVYITPLIGAFLSDSYWG-RYWTStlfqaifvIGLLLLtlssalpslrppqcGDGDLKCPPAS 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 103 SA--GMVNLMIVLVSLGTGLFKCQTNAITGRLFDD--PRELDSA---FSIQYSFVNIGSFIGTTIIGVLVGTKGYAFCFL 175
Cdd:cd17419 112 AAqtTFLYFSLYLIALGYGGYQPCIATLGADQFDDedPIEKASKsafFSYFYQALNLGSLFSNTILVYFEDNGSWGLGFG 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 176 VCGIMMFIDAAWFTFGWRFLGETgkkpfkidehkevkaketkeekkpltsiekKRVAAIILVSFFSVIFWVFWylAYMPV 255
Cdd:cd17419 192 ISAGAAFIGLVLFLAGTPFYREV------------------------------KCILRLLPIWLSTIIYSVVY--TQMAT 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 256 YFYWGGdnAAANWMIGNFQVPTA---WFDSLNALACISL-GPILGKVWSKLAKRPQGdLSMFKKTALGMILLGLSYVIFA 331
Cdd:cd17419 240 LFVEQG--AAMDTSFGNFKIPPAsmsVFEILSVAVGTVLyRKFLVPLLRKVTGHPKG-ITELQRMGIGLVIGILAMVVAA 316
|
....*.
gi 501048329 332 MADVTR 337
Cdd:cd17419 317 LVEIQR 322
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
55-392 |
3.06e-06 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 49.15 E-value: 3.06e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 55 MSANLVAFTYAAPLIGAIIsDRFiGARYLVPIGMVLMGAGYLVGWQASSAGMVNLMIVLV-----SLGTGLFKCQTNAIT 129
Cdd:cd06173 40 LAAFFLPFLLFSPFAGVLA-DRF-DRRRLLILADLLRALLAAVLALLALLGSLSLWLLLVlafllGIASAFFGPARQALL 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 130 GRLFDdPRELDSAFSIQYSFVNIGSFIGTTIIGVLVGTKGYAFCFLVCGIMMFIdAAWFTFGWRFLGETGKKPFKIDEHK 209
Cdd:cd06173 118 PELVP-KEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLL-SALLLLFIRRPPPAAPGESSSLLLR 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 210 EVKAKETKEEKKPLtsiekkRVAAIILVSFFSVIFWVFWYLAYMPVYFYWGGDNAAANWMignfqvptawfdslnaLACI 289
Cdd:cd06173 196 DLREGLRYLRRSPL------LRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLL----------------LAAF 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 290 SLGPILGKVW-SKLAKRpqgdLSMFKKTALGMILLGLSYVIFAMAdvtrggnlAPLAWIIAFGIVLSLGEMVFSPLGNSF 368
Cdd:cd06173 254 GVGALLGALLlGRLSKR----RRRGRLLLIGALLLGLALLVLGLS--------PSLWLLLAALFLLGLAGGLFNVPLNTL 321
|
330 340
....*....|....*....|....
gi 501048329 369 ISKFSPPKLLSSMMSVWVLAVFFA 392
Cdd:cd06173 322 LQLRVPDELRGRVFSVYNALNSGA 345
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
45-413 |
8.62e-06 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 47.81 E-value: 8.62e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 45 LGLSAADAAKMSANLVAFTYAAPLIGAIISDRFiGARYLVPIGMVLMGAGYLVGWQASSAGMVNLMIVLVSLGTGLFKCQ 124
Cdd:cd06174 26 FGLSASQLGLLFALFSLGYALLQPLAGLLADRF-GRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLGSGLIDPA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 125 TNAITGRLFdDPRELDSAFSIQYSFVNIGSFIGTTIIGVLV--GTKGYAFCFLVCGIMMFIDAAWFTFGWRFLGETGKKP 202
Cdd:cd06174 105 VLALIADLF-PERERGRALGLLQAFGSVGGILGPLLGGILAssLGFGWRAVFLIAAALALLAAILLLLVVPDPPESARAK 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 203 FKIDEHKEVKAKETKEEKKPLTSIekkrVAAIILVSFFSVIFWVFWYLAYMPVYFYWGGDNAAANWmignfqvptawfdS 282
Cdd:cd06174 184 NEEASSKSVLKLLKRVLKNPGLWL----LLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLL-------------S 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 283 LNALACISLGPILGKVWSKLAKRPQgdlsmfkKTALGMILLGLSYVIFAMADvtrggnlaPLAWIIAFGIVLSLGEMVFS 362
Cdd:cd06174 247 LFGLAGALGSLLLGLLSDRLIGRKP-------LLLIGLLLMALGLALLLLAP--------SLLLLLLLLLLLGFGLGGLL 311
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 501048329 363 PLGNSFISKFSPPKLLSSMMSVWVLAVFFAAKSYGWVYEFTLKFKFAPTYF 413
Cdd:cd06174 312 PLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGA 362
|
|
| MFS_NPF5 |
cd17417 |
NRT1/PTR family (NPF), subfamily 5 of the Major Facilitator Superfamily of transporters; The ... |
20-337 |
1.29e-05 |
|
NRT1/PTR family (NPF), subfamily 5 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF5 includes Arabidopsis thaliana PTR3 (AtPTR3, now named AtNPF5.2), which is a wound-induced peptide transporter that is necessary for defense against virulent bacterial pathogens. NPF5 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340975 [Multi-domain] Cd Length: 452 Bit Score: 47.26 E-value: 1.29e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 20 LERFAFYSAKWLLAVFVVAKiadggLGLSAADAAKMSANLVAFTYAAPLIGAIISDRFIGaRY---LVPIGMVLMGAGYL 96
Cdd:cd17417 13 AERFAYYGIASNLVTYLTTP-----LHQSTARAAKNVNNWSGTATLLPLLGAFVADAYLG-RYrtiLISSLIYLLGLVLL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 97 V--------------GWQASSAGMVNLM----IVLVSLGTGLFKCQTNAITGRLFDDprELDSAFSIQYSFVN------- 151
Cdd:cd17417 87 TlsaslpslkppecnGTCSKASTLQVAFfffsLYLVAIGQGGHKPCVQAFGADQFDE--DDPKEKKQKSSFFNwwyfsic 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 152 IGSFIGTTIIGVLVGTKGYAFCFLVCGIMMFIDAAWFTFGwrflgeTGKKPFKIDehkevkaketkeekkpltsiEKKRV 231
Cdd:cd17417 165 AGSLTAVTVLVYIQDNVGWALGFGIPTIVMALALFVFLLG------TPLYRYKVE--------------------EVKLV 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 232 AAIILVSFFSVIFWVFWylAYMPVYFYWGGDNAAANwMIGNFQVPTAWFDSLNALACISLGPILGKVWSKLAKRPQGD-- 309
Cdd:cd17417 219 LRLIPIWFTTLVFTVVF--AQSPTFFTKQGVTMDRT-IGPNFKIPPASLQSFITLSILISIPIYDRVFVPIARKITGNpr 295
|
330 340
....*....|....*....|....*....
gi 501048329 310 -LSMFKKTALGMILLGLSYVIFAMADVTR 337
Cdd:cd17417 296 gITLLQRIGIGMFLSILAMVIAALVEMKR 324
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
35-190 |
1.87e-05 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 46.80 E-value: 1.87e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 35 FVVAKIADGGLGLSAADAAKMSANLVAFTYAAPLIGAIISDRFIGARYLVPIGMVLMGAGYLVGWQASSAGMVNLMIVLV 114
Cdd:COG2223 226 SWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLL 305
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 501048329 115 SLGTGLFKCQTNAITGRLFdDPRELDSAFSIQYSFVNIGSFIGTTIIGVLVG-TKGYAFCFLVCGIMMFIDAAWFTF 190
Cdd:COG2223 306 GLALGGGNGAVFALVPDIF-PTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDaTGSYTAAFLVFAVLALVALVLTLL 381
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
35-188 |
2.60e-05 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 46.00 E-value: 2.60e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 35 FVVAKIADGGLGLSAADAAKMSANLVAFTYAapLIGAIISDRfIGARYLVPIGMVLMGAGYLVGWQASSAGMVNLMIVLV 114
Cdd:cd17370 221 FLILRAQELGLSAALIPLLYALFNLVYALAA--YPAGRLSDR-IGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILW 297
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 501048329 115 SLGTGLFKCQTNAITGRLFDdPRELDSAFSIQYSFVNIGSFIGTTIIGVLVGTKGYAFCFLVCGIMMFIDAAWF 188
Cdd:cd17370 298 GLYMGAQESIERAAVADLVP-AELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLLL 370
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
68-385 |
2.80e-05 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 46.03 E-value: 2.80e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 68 LIGAIISDRFiGARYLVPIGMVLMGAGYLVGWQASSAGMVNLMIVLVSLGTGLFKCQTNAITGRLFDdPRELDSAFSIQY 147
Cdd:cd17325 49 PPAGRLSDRF-GRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPAAMALIADIAP-PEERGRAMGIFS 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 148 SFVNIGSFIGTTIIGVLVGTKGYAFCFLVCGIMMFIDAAWftfGWRFLGETGKKPFKIDehkevkaKETKEEKKPLTSIE 227
Cdd:cd17325 127 SAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVL---ALLLLPEPRPPPNKRA-------VSAARLRSGLRLLL 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 228 KKRVAAIILVSFFSVIFWVFWYLAYMPVYfywggdnAAANWMIGNFQVPTAWfdSLNALACISLGPILGKVWSKLAKRPQ 307
Cdd:cd17325 197 RDRRLLALFLAIFVLAFAFGALEPFLPLY-------AAELGGLSPAQIGLLF--GAQGLASALSQPPAGKLSDRIGRKPL 267
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 501048329 308 GdlsmfkktALGMILLGLSYVIFAMADvtrggnlaPLAWIIAFGIVLSLGEMVFSPLGNSFISKFSPPKLLSSMMSVW 385
Cdd:cd17325 268 I--------LIGLLLSAVALLLLPLAT--------SFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLF 329
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
13-403 |
4.17e-05 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 45.64 E-value: 4.17e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 13 VCSIAFTLERFAFYsakwLLAVFVVAKIADggLGLSAADAAKMSANLVAFTYAAPLIGAIISDRFiGARYLVPIGMVLMG 92
Cdd:COG2223 9 LATLAFFLAFGVWY----LWSVLAPPLAEE--FGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRF-GPRRVLLIGLLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 93 AGYLVGWQASSAGMVNLMIVLVSLGTGLFKCQTNAITGRLFDdPRELDSAFSIQYSFVNIGSFIGTTIIGVLVGTKGYAF 172
Cdd:COG2223 82 IGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFP-PDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 173 CFLVCGIMMFIDAAWFtfgWRFLGETGKKPFKidehkevkaketkeekkpltsiEKKRVAAIILVSFFSVIFWVFWYLAY 252
Cdd:COG2223 161 AFLILGILLLVVAVLA---WLFLRDPPAGAAA----------------------AAKASLRDQLEALRDPRFWLLSLLYF 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 253 MPVYFYWGGDNAAANWMIGNFQVPT---AWFDSLNALACISLGPILGKVWSKLAKRpqgdlsmfKKTALGMILLGLSYVI 329
Cdd:COG2223 216 GTFGSFIGFSSWLPPYLVDQFGLSAataGLLAALFALLGALGRPLGGWLSDRIGGR--------RVLLIVFALMALGLLL 287
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 501048329 330 FAMAdvtrggnLAPLAWIIAFGIVLSLGEMVFSPLGNSFISKFSPPKLLSSMMS----VWVLAVFFAAKSYGWVYEFT 403
Cdd:COG2223 288 LALA-------LGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGlvgaAGGLGGFLGPLLFGALLDAT 358
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
53-190 |
4.51e-05 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 45.26 E-value: 4.51e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 53 AKMSANLVAFTYAAPLIGAIISDRF---IGARYLVPIGMVLMGAGYLVGWQASSAGMVNLMIVLVSLGTGLFKCQTNAIT 129
Cdd:cd17473 232 AALIGLALAIASLAGAIGALLFGRLkrrLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWA 311
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 501048329 130 GRLFdDPRELDSAFSIQYSFVNIGSFIGTTIIGVLV-GTKGYAFCFLVCGIMMFIDAAWFTF 190
Cdd:cd17473 312 MSLV-PPELRGRAMGIVTSAFFLGQFLSPLVLGPLVnLTGGLSGAFLILGVLALVLAIVLLL 372
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
9-190 |
5.55e-05 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 45.24 E-value: 5.55e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 9 FGFYVCSIAFTLERFAFYSAKWLLAVFVVAkiadggLGLSAADAAKMSANLVAFTYAAPLIGAIISDRF-IGARYLVPIG 87
Cdd:cd17352 183 PTFVLLALGVSFAMLGFFVPFVYLPSYAKS------LGIDESDAAFLLSIIGISDIVGRILLGLLADKPrIGRLYLYIFT 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 88 MVLMGAGYLVGWQASSAGMVNLMIVLVSLGTGLFKCQTNAITGRLFDdPRELDSAFSIQYSFVNIGSFIGTTIIGVLVG- 166
Cdd:cd17352 257 LLILGLSLLAFPLATTYVGLIVFSVLFGFCSGSYSSLTPVILADLVG-LEKLSNAYGLVLLFQGLAALVGPPIAGLLRDy 335
|
170 180
....*....|....*....|....
gi 501048329 167 TKGYAFCFLVCGIMMFIDAAWFTF 190
Cdd:cd17352 336 TGDYDAAFYFCGACLLLSGVLLFL 359
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
66-392 |
5.73e-05 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 45.26 E-value: 5.73e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 66 APLIGAIIsDRFiGARYLVPIGMVLMGAGYLVGWQASSAGMVNLMIVLVSLGTGLFKCQTNAITGRLFDDPrELDSAFSI 145
Cdd:cd17473 52 APLAGWLA-DRF-GRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGE-ERAKMLGL 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 146 QYSFVNIGSFIGTTIIGVLvGTKGYAFCFLVCGIMMFIdaawFTFGWRFLGETGKKPFKIDEHKEVkaketkeekkPLTS 225
Cdd:cd17473 129 QSAAMSLGGVVFLLLGGAL-AEIGWRAPFLVYLLALPV----LILVLLFLPEPARKSKSAASPGAA----------TAAA 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 226 IEKKRVAAIILVSFF-SVIFWVFwyLAYMPvyFYWGGDNAAANWMIGNfqvptawfdslnALACISLGPILGKVWSKLAK 304
Cdd:cd17473 194 LPWKRVLPIYFLAFLaMLLFYVI--PIQLP--FLLQERGGGSAALIGL------------ALAIASLAGAIGALLFGRLK 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 305 RPQGDLSMFkktALGMILLGLSYVIFAMAdvtrggnlAPLAWIIAFGIVLSLGEMVFSPLGNSFISKFSPPKLLSSMMSV 384
Cdd:cd17473 258 RRLGKRRLL---AIGFALMALGFLLLALA--------SGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGI 326
|
....*...
gi 501048329 385 WVLAVFFA 392
Cdd:cd17473 327 VTSAFFLG 334
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
45-194 |
1.11e-04 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 44.09 E-value: 1.11e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 45 LGLSAADAAKMSANLVAFTYAAPLIGAIISDRFIGARYLVPIGMVLMGAGYLVGWQASSAGMVnLMIVLVSLGTGLFKCQ 124
Cdd:COG2807 245 AGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPW-LWAVLLGLGQGGLFPL 323
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 501048329 125 TNAITGRLFDDPRELDSAFSIQYSFVNIGSFIGTTIIGVLVG-TKGYAFCFLVCGIMMfidAAWFTFGWRF 194
Cdd:COG2807 324 ALTLIGLRARTPAEAAALSGMAQSVGYLLAALGPLLVGALHDaTGSWTAALLLLAALA---VLMLVAGLLA 391
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
34-181 |
5.88e-04 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 41.87 E-value: 5.88e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 34 VFVVAKIADGGLGLSAADAAkMSANLVAFTYAAPLIGAIIsDRFiGARYLVPIGMVLMGAGY-LVGWQASSAGMVNLMIV 112
Cdd:cd17355 24 VFIIPIIAEFGWSRAVISLA-FTVGLLAFGLAQPFVGRLL-DRF-GPRRVMLLGLLLLAAGLvLLALATSLWQLYLLWGL 100
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 113 LVSLGTG-LFKCQTNAITGRLFDDPRELdsAFSIQYSFVNIGSFIGTTIIGVLVGTKGYAFCFLVCGIMM 181
Cdd:cd17355 101 LGGGGAGtLAAVAFATVAAWWFERRRGL--ALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLA 168
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
45-183 |
5.99e-04 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 42.03 E-value: 5.99e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 45 LGLSAADAAKMSANLVAFTYAAPLIGAIISDRFIGARYLVPIGMVLMGAGYLVGWQASSAGMVNLMIVLVSLGTGLFKCQ 124
Cdd:cd06174 234 GGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPL 313
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 125 TNAITGRLFdDPRELDSAFSIQYSFVNIGSFIGTTIIGVL-VGTKGYAFCFLVCGIMMFI 183
Cdd:cd06174 314 SFALIAELF-PPEIRGTAFGLLNTFGFLGGAIGPLLAGFLlAATFGLTGAFLVLAVLLLL 372
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
45-189 |
8.41e-04 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 41.39 E-value: 8.41e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 45 LGLSAADAAKM-SANLVAFTYAAPLIGaIISDRFiGARYLVPIGMVLMGAGYLVGWQASSAGMVNLMIVLVSLGTGLFKC 123
Cdd:COG2271 40 LGLSAAQLGLLaSAFFLGYALGQIPAG-LLADRF-GRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFP 117
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 501048329 124 QTNAITGRLFdDPRELDSAFSIQYSFVNIGSFIGTTIIGVLVGTKGYAFCFLVCGIMMFIDAAWFT 189
Cdd:COG2271 118 AALKLIAEWF-PPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLALLRF 182
|
|
| 2A1704 |
TIGR00926 |
Peptide:H+ symporter (also transports b-lactam antibiotics, the antitumor agent, bestatin, and ... |
59-336 |
1.02e-03 |
|
Peptide:H+ symporter (also transports b-lactam antibiotics, the antitumor agent, bestatin, and various protease inhibitors); [Transport and binding proteins, Amino acids, peptides and amines]
Pssm-ID: 273343 [Multi-domain] Cd Length: 654 Bit Score: 41.67 E-value: 1.02e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 59 LVAFTYAAPLIGAIISDRFIGARYLVPIGMVLmgagYLVGWQASSAGMVN------------LMIVLVSLGTGLFKCQTN 126
Cdd:TIGR00926 32 FTYLCYLTPLIGAIIADGWLGKFKTILYLSIV----YVVGHALLSFGAIPssghplhdlldlLGLALIALGTGGIKPCVS 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 127 AITGRLF--DDPRELDSAFSIQYSFVNIGSFIGTTIIGVLVGTKG-------YAFCFLVCGIMMFIDAAWFTFGWRFL-- 195
Cdd:TIGR00926 108 AFGGDQFeeRQLSLRSRFFSFFYFAINAGSLISTIITPILRGDVGcfgcqdcYPLAFGVPAILMILALIVFMAGSKMYkk 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 196 -----GETGKKPFKI-----------DEHKEVKAKETKEEKKPLTSIEKKRvaaIILVSFFSVI-FWVFWYLaYMPVYFY 258
Cdd:TIGR00926 188 kppkgNIVSKVIKCIvtalrkrfstrSEHWPLHWLDYAKDKHDIRMIRSTK---RLLRVLVLFIpLPMFWAL-FDQQGSR 263
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 501048329 259 WGGDNAAANWMIGNFQVPTAWFDSLNALACISLGPILGKVWSKLAKRPQGDLSMFKKTALGMILLGLSYVIFAMADVT 336
Cdd:TIGR00926 264 WTLQATRMDGDVGGFEIQPDQMQVVNPLLILIFVPIFDYIVYPAIAKCGTRFTSLRKMAVGGLLAALSFFVAALVQLK 341
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
55-190 |
1.48e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 40.66 E-value: 1.48e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 55 MSANLVAFTYAAPLIGAIIsDRFIGARYLVPiGMVLMGAGYLVGWQASSAGMVNLMIVLVSLGTGLFKCQTNAITGRLFD 134
Cdd:cd17489 233 FTVYAIALLLSRPFSGKLS-DRKGPKTVIIP-GLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVP 310
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 501048329 135 dPRELDSAFSIQYSFVNIGSFIGTTIIGVLVGTKGYAFCFLVCGIMMFIDAAWFTF 190
Cdd:cd17489 311 -PHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIF 365
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
55-190 |
2.00e-03 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 40.25 E-value: 2.00e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 55 MSANLVAFTYAAPLIGAIISDRFiGARYLVPIGMVLMGAGYLVGWQASSAGMVNLMIVLVSLGTGL-FKCQTNAITGRLf 133
Cdd:cd17474 240 FAGWSVLLALGSLFVGRLLKKRF-GARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLnLPLLTTLVTELA- 317
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 501048329 134 ddPRELDSAFSIQYSFV-NIGSFIGTTIIGVLVGTKGYAFCFLVCGIMMFIdAAWFTF 190
Cdd:cd17474 318 --PEEERGTASSLYNFVrFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALA-AAVLLA 372
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
41-183 |
2.01e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 40.25 E-value: 2.01e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 41 ADGGLGLSAADAAK-MSANLVAFTYAAPLIGAIIsdRFIGARYLVPIGMVLMGAGYL-VGWQASSAGMVNLMIVLVSLGT 118
Cdd:cd17504 208 TPTGFGLGITEAGLlLLPGALVMLIAGPLAGRLI--ARVGPRRVLLIGLVISAVGLLlLALLHSSLWALVVALLLIGIGL 285
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 501048329 119 GL-FKCQTNAITGRLfdDPRELDSAFSIQYSFVNIGSFIGTTIIGVLV-------------GTKGYAFCFLVCGIMMFI 183
Cdd:cd17504 286 GLaFASLPNIVVESV--PPDRTGIATGMNTVLRTIGSAIGPAIAGAILttytvsitsggvpTEGAYVLAFLIGAALALA 362
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
67-278 |
3.81e-03 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 39.46 E-value: 3.81e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 67 PLIGaIISDRFiGARYLVPIGMVLMGAGYLVGWQASSAGMVNLMIVLVSLGTGLFKCQTNAITGRLFDDPRELdsAFSIQ 146
Cdd:cd17478 49 PLFG-YLADRK-PRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAAFHPEGARLASQAAGGRRGL--AMSIF 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 147 YSFVNIGSFIGTTIIGVLVGTKGYAFCFLVCGIMmFIDAAWFTFGWRFLGETGKKPFKidehkevkaketKEEKKPLTSI 226
Cdd:cd17478 125 SVGGNLGFALGPLIAAALVALFGGLGLLILLIIP-GLAVALLLLRLRPLKKPEAKKAA------------AKSSARSTLK 191
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 501048329 227 EKKRVAAIILVSFFSVIFWVFWYLAYMPVYF-YWGGDNAAANWMIGNFQVPTA 278
Cdd:cd17478 192 GVWRALLLLLIIVFLRSWVLSSLTTFLPFYLvQRGYSLVFAGLLLSLFLFAGA 244
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
16-190 |
4.32e-03 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 39.09 E-value: 4.32e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 16 IAFTLERFAFYSAKWLLaVFVVAKIADGGLGLSAADAAKMSANLVAFTYAAPLIGAIISDRFIG--ARYLVPIGMVLMGA 93
Cdd:cd17319 182 WGLALGYFGINYALYGL-LTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRgaRRLVIIIGLLLAAV 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 94 GYLVGWQASSAGMVNLMIVLVSLGTGLFKCQTNAITGRLFDdPRELDSAFSIQYSFVNIGSFIGTTIIGVLVG-TKGYAF 172
Cdd:cd17319 261 GLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLP-GEAAATAGGLINSGGNLGGFVAPLLIGYLVDaTGSYTA 339
|
170
....*....|....*...
gi 501048329 173 CFLVCGIMMFIDAAWFTF 190
Cdd:cd17319 340 AFLFLAAVALLAALLVLL 357
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
44-183 |
6.23e-03 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 38.68 E-value: 6.23e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 44 GLGLSAADAAkmsaNLVAFTYAAPLIGAIISD---RFIGARYLVPIGMVLMGAGYLVGWQASSAGMVNLMIVLVSLGTGL 120
Cdd:COG0738 240 VLGLSEATAA----LGLSLFWGGMTIGRFLGGfllKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSL 315
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 501048329 121 FKCQTNAITGRLFddPRELDSAFSIQYSFVNIGSFIGTTIIGVLVGTKGYAFCFLVCGIMMFI 183
Cdd:COG0738 316 MFPTIFSLALDGL--GKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLL 376
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
65-252 |
7.70e-03 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 38.46 E-value: 7.70e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 65 AAPLIGAIISDRFIGARYLVpIGMVLMGAGYLVGWQASSAGMVNLMIVLVSLGTGLFKCQTNAITGRLFddPRELDSAFS 144
Cdd:cd17333 46 IGSLLAGFLMKRLGRRRTLI-LGLLLISLALALIFATPSIYLFVVLMFLAGLGAGILDTGANTFVGALF--EESSATRLN 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501048329 145 IQYSFVNIGSFIGTTIIGVLVGTK-GYAFCFLVCGIMMFIDAAWFTFgwrflgetgkkpFKIDEHKEVKAKETKEEKKPL 223
Cdd:cd17333 123 VLHGFFGLGALIGPLIATSLLTSElSWSWAYLIIGLIYLLLAILILL------------TLFPELPSARNPQQSVGAFSA 190
|
170 180 190
....*....|....*....|....*....|....*...
gi 501048329 224 TSIEKKRVAAIILVSFF---------SVIFWVFWYLAY 252
Cdd:cd17333 191 SASRLLRNPSIILGALAlflyvgaetAFSSWVPSYLVE 228
|
|
| |
