NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|501056953|ref|WP_012108403|]
View 

response regulator transcription factor [Campylobacter hominis]

Protein Classification

response regulator transcription factor( domain architecture ID 11433066)

OmpR family response regulator transcription factor with a signal receiver (REC) domain and a helix-turn-helix (HTH) DNA-binding domain that may be part of a two-component regulatory system

CATH:  3.40.50.2300
Gene Ontology:  GO:0006355|GO:0003677|GO:0000160|GO:0000156
PubMed:  11226872|10966457|31100988
SCOP:  4003632

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
 1-206 1.78e-43

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


:

Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 144.71  E-value: 1.78e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   1 MNRILVLEDENMLNEMICDFLVANHFEVKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRKSGKNTPCIFTT 80
Cdd:COG0745    1 MPRILVVEDDPDIRELLADALEREGYEVDTAADGEEALELLEEERPDLILLDLMLPGMDGLEVCRRLRARPSDIPIIMLT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953  81 SLNDINDLNKGFLSGCDDYLKKPFELAELLLRINNllrrnfAHKNSHIEKLCDGLAFDIYEKRLFKNGEPVNLSKKEMTL 160
Cdd:COG0745   81 ARDDEEDRVRGLEAGADDYLTKPFDPEELLARIRA------LLRRRAAEVLRVGDLLDLAAREVTRDGEPVELTPKEFRL 154

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 501056953 161 LTLLLQKKNKSVSREEIYSAVWDIDEmPSELSLRVYIRNLRKIFGK 206
Cdd:COG0745  155 LELLMRNPGRVVSREQLLEEVWGYDY-GDDRTVDVHISRLRKKLED 199
 
Name Accession Description Interval E-value
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
 1-206 1.78e-43

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 144.71  E-value: 1.78e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   1 MNRILVLEDENMLNEMICDFLVANHFEVKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRKSGKNTPCIFTT 80
Cdd:COG0745    1 MPRILVVEDDPDIRELLADALEREGYEVDTAADGEEALELLEEERPDLILLDLMLPGMDGLEVCRRLRARPSDIPIIMLT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953  81 SLNDINDLNKGFLSGCDDYLKKPFELAELLLRINNllrrnfAHKNSHIEKLCDGLAFDIYEKRLFKNGEPVNLSKKEMTL 160
Cdd:COG0745   81 ARDDEEDRVRGLEAGADDYLTKPFDPEELLARIRA------LLRRRAAEVLRVGDLLDLAAREVTRDGEPVELTPKEFRL 154

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 501056953 161 LTLLLQKKNKSVSREEIYSAVWDIDEmPSELSLRVYIRNLRKIFGK 206
Cdd:COG0745  155 LELLMRNPGRVVSREQLLEEVWGYDY-GDDRTVDVHISRLRKKLED 199
REC_OmpR cd17574
phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins ...
 5-103 3.46e-28

phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins are one of the most widespread transcriptional regulators. OmpR family members contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domain. They are involved in the control of environmental stress tolerance (such as the oxidative, osmotic and acid stress response), motility, virulence, outer membrane biogenesis and other processes. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381116 [Multi-domain]  Cd Length: 99  Bit Score: 102.10  E-value: 3.46e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   5 LVLEDENMLNEMICDFLVANHFEVKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRKSGKNTPCIFTTSLND 84
Cdd:cd17574    1 LVVEDDEEIAELLSDYLEKEGYEVDTAADGEEALELAREEQPDLIILDVMLPGMDGFEVCRRLREKGSDIPIIMLTAKDE 80

                         90
                 ....*....|....*....
gi 501056953  85 INDLNKGFLSGCDDYLKKP 103
Cdd:cd17574   81 EEDKVLGLELGADDYITKP 99
cztR_silR_copR TIGR01387
heavy metal response regulator; Members of this family contain a response regulator receiver ...
 4-218 6.98e-25

heavy metal response regulator; Members of this family contain a response regulator receiver domain (pfam00072) and an associated transcriptional regulatory region (pfam00486). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc. Most members encoded by genes adjacent to genes for encoding a member of the heavy metal sensor histidine kinase family (TIGRFAMs:TIGR01386), its partner in the two-component response regulator system. [Regulatory functions, DNA interactions]


Pssm-ID: 130454 [Multi-domain]  Cd Length: 218  Bit Score: 97.18  E-value: 6.98e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953    4 ILVLEDENMLNEMICDFLVANHFEVKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRKSGKNTPCIFTTSLN 83
Cdd:TIGR01387   1 ILVVEDEQKTAEYLQQGLSESGYVVDAASNGRDGLHLALKDDYDLIILDVMLPGMDGWQILQTLRRSGKQTPVLFLTARD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   84 DINDLNKGFLSGCDDYLKKPFELAELLLRINNLLRRNfAHKNSHIEKLCDgLAFDIYEKRLFKNGEPVNLSKKEMTLLTL 163
Cdd:TIGR01387  81 SVADKVKGLDLGADDYLVKPFSFSELLARVRTLLRRS-HSLNSTVLEIAD-LRMDSVRHRVSRGNIRITLTRKEFQLLWL 158

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953  164 LLQKKNKSVSREEIYSAVWDIDEMPSELSLRVYIRNLR-KIFG----KHIVSISKVGYSY 218
Cdd:TIGR01387 159 LMRRTGEVLPRTVIASLVWGMNFDSDTNVVDVAIRRLRaKVDDpfeeKLIHTIRGMGYVL 218
PRK10161 PRK10161
phosphate response regulator transcription factor PhoB;
3-218 7.21e-20

phosphate response regulator transcription factor PhoB;


Pssm-ID: 182277 [Multi-domain]  Cd Length: 229  Bit Score: 84.38  E-value: 7.21e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   3 RILVLEDENMLNEMICDFLVANHFEVKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRKSG--KNTPCIFTT 80
Cdd:PRK10161   4 RILVVEDEAPIREMVCFVLEQNGFQPVEAEDYDSAVNQLNEPWPDLILLDWMLPGGSGIQFIKHLKRESmtRDIPVVMLT 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953  81 SLNDINDLNKGFLSGCDDYLKKPFELAELLLRINNLLRRNFAHKNSHIEKLcDGLAFDIYEKRLFKNGEPVNLSKKEMTL 160
Cdd:PRK10161  84 ARGEEEDRVRGLETGADDYITKPFSPKELVARIKAVMRRISPMAVEEVIEM-QGLSLDPTSHRVMAGEEPLEMGPTEFKL 162

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 501056953 161 LTLLLQKKNKSVSREEIYSAVWDIDEMPSELSLRVYIRNLRKIF-----GKHIVSISKVGYSY 218
Cdd:PRK10161 163 LHFFMTHPERVYSREQLLNHVWGTNVYVEDRTVDVHIRRLRKALepgghDRMVQTVRGTGYRF 225
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 4-108 3.74e-14

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 66.02  E-value: 3.74e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953    4 ILVLEDENMLNEMICDFLVANHFEVKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRKSGKNTPCIFTTSLN 83
Cdd:pfam00072   1 VLIVDDDPLIRELLRQLLEKEGYVVAEADDGKEALELLKEERPDLILLDINMPGMDGLELLKRIRRRDPTTPVIILTAHG 80

                          90       100
                  ....*....|....*....|....*
gi 501056953   84 DINDLNKGFLSGCDDYLKKPFELAE 108
Cdd:pfam00072  81 DEDDAVEALEAGADDFLSKPFDPDE 105
Trans_reg_C smart00862
Transcriptional regulatory protein, C terminal; This domain is almost always found associated ...
 148-216 1.36e-12

Transcriptional regulatory protein, C terminal; This domain is almost always found associated with the response regulator receiver domain. It may play a role in DNA binding.


Pssm-ID: 214866 [Multi-domain]  Cd Length: 76  Bit Score: 61.03  E-value: 1.36e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 501056953   148 GEPVNLSKKEMTLLTLLLQKKNKSVSREEIYSAVWDIDEMPSELSLRVYIRNLRKIFGK-----HIVSISKVGY 216
Cdd:smart00862   1 GEPIKLTPKEFRLLELLLRNPGRVVSREELLEAVWGDDEDVDDNTLDVHISRLRKKLEDdgdprLIETVRGVGY 74
MtrAB_MtrA NF040689
MtrAB system response regulator MtrA;
4-182 1.89e-10

MtrAB system response regulator MtrA;


Pssm-ID: 468653 [Multi-domain]  Cd Length: 219  Bit Score: 58.34  E-value: 1.89e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   4 ILVLEDENMLNEMICDFLVANHFEVKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRKSgKNTPCIFTTSLN 83
Cdd:NF040689   1 ILVVDDDPALAEMLGIVLRAEGFETVFCADGAEAVEAFREVRPDLVLLDLMLPGMDGIEVCRQIRAE-SGVPIIMLTAKS 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953  84 DINDLNKGFLSGCDDYLKKPFELAELLLRINNLLRRNFAHKNSHIEklCDGLAFDIYEKRLFKNGEPVNLSKKEMTLLTL 163
Cdd:NF040689  80 DTVDVVRGLEAGADDYVVKPFKPKELVARIRARLRRSEDEESEVLR--IGDLTIDVAGHEVTRGGEEIPLTPLEFDLLVA 157

                        170
                 ....*....|....*....
gi 501056953 164 LLQKKNKSVSREEIYSAVW 182
Cdd:NF040689 158 LARKPGQVFSREELLEQVW 176
resp_reg_YycF NF040534
response regulator YycF;
3-216 2.80e-08

response regulator YycF;


Pssm-ID: 439744 [Multi-domain]  Cd Length: 231  Bit Score: 52.42  E-value: 2.80e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   3 RILVLEDENMLNEMICDFLVANHFEVKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRKSgKNTPCIFTTSL 82
Cdd:NF040534   2 KILVVDDEKPIADILEFNLKKEGYEVFCAYDGNEALELVEEEVPDLVLLDIMLPGRDGMEVCREVRKK-YDMPIIMLTAK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953  83 NDINDLNKGFLSGCDDYLKKPFELAELLLRINNLLRRNFAHKNSHIEKLCDglafDIYEKRLF---------KNGEPVNL 153
Cdd:NF040534  81 DSEIDKVLGLELGADDYVTKPFSTRELIARVKANLRRHQQQNTEEEEEENN----EIVIGSLTihpdaytvkKRGETIEL 156

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 501056953 154 SKKEMTLLTLLLQKKNKSVSREEIYSAVWDIDEMPSELSLRVYIRNLR-KI-----FGKHIVSISKVGY 216
Cdd:NF040534 157 THREFELLHYLAKHIGQVMTREHLLQTVWGYDYFGDVRTVDVTVRRLReKIednpsHPEWIVTRRGVGY 225
 
Name Accession Description Interval E-value
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
 1-206 1.78e-43

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 144.71  E-value: 1.78e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   1 MNRILVLEDENMLNEMICDFLVANHFEVKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRKSGKNTPCIFTT 80
Cdd:COG0745    1 MPRILVVEDDPDIRELLADALEREGYEVDTAADGEEALELLEEERPDLILLDLMLPGMDGLEVCRRLRARPSDIPIIMLT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953  81 SLNDINDLNKGFLSGCDDYLKKPFELAELLLRINNllrrnfAHKNSHIEKLCDGLAFDIYEKRLFKNGEPVNLSKKEMTL 160
Cdd:COG0745   81 ARDDEEDRVRGLEAGADDYLTKPFDPEELLARIRA------LLRRRAAEVLRVGDLLDLAAREVTRDGEPVELTPKEFRL 154

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 501056953 161 LTLLLQKKNKSVSREEIYSAVWDIDEmPSELSLRVYIRNLRKIFGK 206
Cdd:COG0745  155 LELLMRNPGRVVSREQLLEEVWGYDY-GDDRTVDVHISRLRKKLED 199
REC_OmpR cd17574
phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins ...
 5-103 3.46e-28

phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins are one of the most widespread transcriptional regulators. OmpR family members contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domain. They are involved in the control of environmental stress tolerance (such as the oxidative, osmotic and acid stress response), motility, virulence, outer membrane biogenesis and other processes. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381116 [Multi-domain]  Cd Length: 99  Bit Score: 102.10  E-value: 3.46e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   5 LVLEDENMLNEMICDFLVANHFEVKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRKSGKNTPCIFTTSLND 84
Cdd:cd17574    1 LVVEDDEEIAELLSDYLEKEGYEVDTAADGEEALELAREEQPDLIILDVMLPGMDGFEVCRRLREKGSDIPIIMLTAKDE 80

                         90
                 ....*....|....*....
gi 501056953  85 INDLNKGFLSGCDDYLKKP 103
Cdd:cd17574   81 EEDKVLGLELGADDYITKP 99
REC_OmpR_DrrD-like cd17625
phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a ...
 5-108 2.40e-25

phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a OmpR/PhoB homolog from Thermotoga maritima whose function is not yet known. This subfamily also includes Streptococcus agalactiae transcriptional regulatory protein DltR, part of the DltS/DltR two-component system (TCS), and Pseudomonas aeruginosa transcriptional activator protein PfeR, part of the PfeR/PfeS TCS, which activates expression of the ferric enterobactin receptor. The DltS/DltR TCS regulates the expression of the dlt operon, which comprises four genes (dltA, dltB, dltC, and dltD) that catalyze the incorporation of D-alanine residues into the lipoteichoic acids. Members of this subfamily belong to the OmpR/PhoB family, which comprises of two domains, an N-terminal receiver domain and a C-terminal DNA-binding winged helix-turn-helix effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381140 [Multi-domain]  Cd Length: 115  Bit Score: 95.37  E-value: 2.40e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   5 LVLEDENMLNEMICDFLVANHFEVKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRKSGKNTPCIFTTSLND 84
Cdd:cd17625    1 LVVEDEKDLSEAITKHLKKEGYTVDVCFDGEEGLEYALSGIYDLIILDIMLPGMDGLEVLKSLREEGIETPVLLLTALDA 80

                         90       100
                 ....*....|....*....|....
gi 501056953  85 INDLNKGFLSGCDDYLKKPFELAE 108
Cdd:cd17625   81 VEDRVKGLDLGADDYLPKPFSLAE 104
cztR_silR_copR TIGR01387
heavy metal response regulator; Members of this family contain a response regulator receiver ...
 4-218 6.98e-25

heavy metal response regulator; Members of this family contain a response regulator receiver domain (pfam00072) and an associated transcriptional regulatory region (pfam00486). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc. Most members encoded by genes adjacent to genes for encoding a member of the heavy metal sensor histidine kinase family (TIGRFAMs:TIGR01386), its partner in the two-component response regulator system. [Regulatory functions, DNA interactions]


Pssm-ID: 130454 [Multi-domain]  Cd Length: 218  Bit Score: 97.18  E-value: 6.98e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953    4 ILVLEDENMLNEMICDFLVANHFEVKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRKSGKNTPCIFTTSLN 83
Cdd:TIGR01387   1 ILVVEDEQKTAEYLQQGLSESGYVVDAASNGRDGLHLALKDDYDLIILDVMLPGMDGWQILQTLRRSGKQTPVLFLTARD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   84 DINDLNKGFLSGCDDYLKKPFELAELLLRINNLLRRNfAHKNSHIEKLCDgLAFDIYEKRLFKNGEPVNLSKKEMTLLTL 163
Cdd:TIGR01387  81 SVADKVKGLDLGADDYLVKPFSFSELLARVRTLLRRS-HSLNSTVLEIAD-LRMDSVRHRVSRGNIRITLTRKEFQLLWL 158

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953  164 LLQKKNKSVSREEIYSAVWDIDEMPSELSLRVYIRNLR-KIFG----KHIVSISKVGYSY 218
Cdd:TIGR01387 159 LMRRTGEVLPRTVIASLVWGMNFDSDTNVVDVAIRRLRaKVDDpfeeKLIHTIRGMGYVL 218
PleD COG3706
Two-component response regulator, PleD family, consists of two REC domains and a diguanylate ...
 1-108 4.39e-22

Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 442920 [Multi-domain]  Cd Length: 179  Bit Score: 88.81  E-value: 4.39e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   1 MNRILVLEDENMLNEMICDFLVANHFEVKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRK--SGKNTPCIF 78
Cdd:COG3706    1 PARILVVDDDPTNRKLLRRLLEAAGYEVVEAADGEEALELLQEHRPDLILLDLEMPDMDGLELCRRLRAdpRTADIPIIF 80

                         90       100       110
                 ....*....|....*....|....*....|
gi 501056953  79 TTSLNDINDLNKGFLSGCDDYLKKPFELAE 108
Cdd:COG3706   81 LTALDDEEDRARALEAGADDYLTKPFDPEE 110
REC_OmpR_PmrA-like cd17624
phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This ...
 4-108 3.85e-21

phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This subfamily contains various OmpR family response regulators including PmrA, BasR, QseB, tctD, and RssB, which are components of two-component regulatory systems (TCSs). The PmrA/PmrB TCS controls transcription of genes that are involved in lipopolysaccharide modification in the outer membrane of bacteria, increasing bacterial resistance to host-derived antimicrobial peptides. The BasS/BasR TCS functions as an iron- and zinc-sensing transcription regulator. The QseB/QseC TCS activates the flagella regulon by activating transcription of FlhDC. The RssA/RssB TCS regulates swarming behavior in Serratia marcescens. OmpR family DNA-binding response regulators contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381139 [Multi-domain]  Cd Length: 115  Bit Score: 84.46  E-value: 3.85e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   4 ILVLEDENMLNEMICDFLVANHFEVKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRKSGKNTPCIFTTSLN 83
Cdd:cd17624    1 ILLVEDDALLGDGLKTGLRKAGYAVDWVRTGAEAEAALASGPYDLVILDLGLPDGDGLDLLRRWRRQGQSLPVLILTARD 80

                         90       100
                 ....*....|....*....|....*
gi 501056953  84 DINDLNKGFLSGCDDYLKKPFELAE 108
Cdd:cd17624   81 GVDDRVAGLDAGADDYLVKPFALEE 105
CitB COG4565
DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal ...
 1-108 9.04e-21

DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal transduction mechanisms];


Pssm-ID: 443622 [Multi-domain]  Cd Length: 138  Bit Score: 84.25  E-value: 9.04e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   1 MNRILVLEDENMLNEMICDFL--VANHFEVKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRKSGKNTPCIF 78
Cdd:COG4565    3 MIRVLIVEDDPMVAELLRRYLerLPGFEVVGVASSGEEALALLAEHRPDLILLDIYLPDGDGLELLRELRARGPDVDVIV 82

                         90       100       110
                 ....*....|....*....|....*....|
gi 501056953  79 TTSLNDINDLNKGFLSGCDDYLKKPFELAE 108
Cdd:COG4565   83 ITAARDPETVREALRAGVVDYLIKPFTFER 112
REC cd00156
phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response ...
 5-103 2.70e-20

phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs); Two-component systems (TCSs) involving a sensor and a response regulator are used by bacteria to adapt to changing environments. Processes regulated by two-component systems in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Response regulators (RRs) share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. Response regulators regulate transcription, post-transcription or post-translation, or have functions such as methylesterases, adenylate or diguanylate cyclase, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases, and protein phosphatases, depending on their output domains. The function of some output domains are still unknown. TCSs are found in all three domains of life - bacteria, archaea, and eukaryotes, however, the presence and abundance of particular RRs vary between the lineages. Archaea encode very few RRs with DNA-binding output domains; most are stand-alone REC domains. Among eukaryotes, TCSs are found primarily in protozoa, fungi, algae, and green plants. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381085 [Multi-domain]  Cd Length: 99  Bit Score: 81.89  E-value: 2.70e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   5 LVLEDENMLNEMICDFLVANHFEVKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRKSGKNTPCIFTTSLND 84
Cdd:cd00156    1 LIVDDDPAIRELLKSLLEREGYEVDTAADGEEALELLREERPDLVLLDLMMPGMDGLELLRKLRELPPDIPVIVLTAKAD 80

                         90
                 ....*....|....*....
gi 501056953  85 INDLNKGFLSGCDDYLKKP 103
Cdd:cd00156   81 EEDAVRALELGADDYLVKP 99
RpfG COG3437
Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains ...
 3-108 4.01e-20

Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains [Signal transduction mechanisms];


Pssm-ID: 442663 [Multi-domain]  Cd Length: 224  Bit Score: 84.83  E-value: 4.01e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   3 RILVLEDENMLNEMICDFLVANHFEVKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRK--SGKNTPCIFTT 80
Cdd:COG3437    8 TVLIVDDDPENLELLRQLLRTLGYDVVTAESGEEALELLLEAPPDLILLDVRMPGMDGFELLRLLRAdpSTRDIPVIFLT 87

                         90       100
                 ....*....|....*....|....*...
gi 501056953  81 SLNDINDLNKGFLSGCDDYLKKPFELAE 108
Cdd:COG3437   88 ALADPEDRERALEAGADDYLTKPFDPEE 115
PRK10161 PRK10161
phosphate response regulator transcription factor PhoB;
3-218 7.21e-20

phosphate response regulator transcription factor PhoB;


Pssm-ID: 182277 [Multi-domain]  Cd Length: 229  Bit Score: 84.38  E-value: 7.21e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   3 RILVLEDENMLNEMICDFLVANHFEVKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRKSG--KNTPCIFTT 80
Cdd:PRK10161   4 RILVVEDEAPIREMVCFVLEQNGFQPVEAEDYDSAVNQLNEPWPDLILLDWMLPGGSGIQFIKHLKRESmtRDIPVVMLT 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953  81 SLNDINDLNKGFLSGCDDYLKKPFELAELLLRINNLLRRNFAHKNSHIEKLcDGLAFDIYEKRLFKNGEPVNLSKKEMTL 160
Cdd:PRK10161  84 ARGEEEDRVRGLETGADDYITKPFSPKELVARIKAVMRRISPMAVEEVIEM-QGLSLDPTSHRVMAGEEPLEMGPTEFKL 162

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 501056953 161 LTLLLQKKNKSVSREEIYSAVWDIDEMPSELSLRVYIRNLRKIF-----GKHIVSISKVGYSY 218
Cdd:PRK10161 163 LHFFMTHPERVYSREQLLNHVWGTNVYVEDRTVDVHIRRLRKALepgghDRMVQTVRGTGYRF 225
AtoC COG2204
DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, ...
 1-108 8.52e-20

DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains [Signal transduction mechanisms];


Pssm-ID: 441806 [Multi-domain]  Cd Length: 418  Bit Score: 86.56  E-value: 8.52e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   1 MNRILVLEDENMLNEMICDFLVANHFEVKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRKSGKNTPCIFTT 80
Cdd:COG2204    2 MARILVVDDDPDIRRLLKELLERAGYEVETAASGEEALALLREEPPDLVLLDLRMPGMDGLELLRELRALDPDLPVILLT 81

                         90       100
                 ....*....|....*....|....*...
gi 501056953  81 SLNDINDLNKGFLSGCDDYLKKPFELAE 108
Cdd:COG2204   82 GYGDVETAVEAIKAGAFDYLTKPFDLEE 109
CheY COG0784
CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator ...
 3-108 4.40e-19

CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator Spo0F [Signal transduction mechanisms];


Pssm-ID: 440547 [Multi-domain]  Cd Length: 128  Bit Score: 79.51  E-value: 4.40e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   3 RILVLEDENMLNEMICDFLVANHFEVKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRK--SGKNTPCIFTT 80
Cdd:COG0784    7 RILVVDDNPDNRELLRRLLERLGYEVTTAEDGAEALELLRAGPPDLILLDINMPGMDGLELLRRIRAlpRLPDIPIIALT 86

                         90       100
                 ....*....|....*....|....*...
gi 501056953  81 SLNDINDLNKGFLSGCDDYLKKPFELAE 108
Cdd:COG0784   87 AYADEEDRERALEAGADDYLTKPVDPEE 114
PRK10643 PRK10643
two-component system response regulator PmrA;
3-216 5.86e-19

two-component system response regulator PmrA;


Pssm-ID: 182612 [Multi-domain]  Cd Length: 222  Bit Score: 81.62  E-value: 5.86e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   3 RILVLEDENMLNEMICDFLVANHFEVKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRKSGKNTPCIFTTSL 82
Cdd:PRK10643   2 KILIVEDDTLLLQGLILALQTEGYACDCASTAREAEALLESGHYSLVVLDLGLPDEDGLHLLRRWRQKKYTLPVLILTAR 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953  83 NDINDLNKGFLSGCDDYLKKPFELAELLLRINNLLRRNFAHKNSHIEKlcDGLAFDIYEKRLFKNGEPVNLSKKEMTLLT 162
Cdd:PRK10643  82 DTLEDRVAGLDVGADDYLVKPFALEELHARIRALIRRHQGQGENELQV--GNLTLNLGRQQVWLDGQELILTPKEFALLS 159

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 501056953 163 LLLQKKNKSVSREEIYSAVWDIDEMPSELSLRVYIRNLRKIFGK-HIVSISKVGY 216
Cdd:PRK10643 160 RLMLKAGSPVHREILYQDIYNWDDEPSSNTLEVHIHNLRDKVGKdRIRTVRGFGY 214
PRK15479 PRK15479
transcriptional regulator TctD;
3-217 1.01e-18

transcriptional regulator TctD;


Pssm-ID: 185376 [Multi-domain]  Cd Length: 221  Bit Score: 80.92  E-value: 1.01e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   3 RILVLEDENMLNEMICDFLVANHFEVKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRKSGKNTPCIFTTSL 82
Cdd:PRK15479   2 RLLLAEDNRELAHWLEKALVQNGFAVDCVFDGLAADHLLQSEMYALAVLDINMPGMDGLEVLQRLRKRGQTLPVLLLTAR 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953  83 NDINDLNKGFLSGCDDYLKKPFELAELLLRINNLLRRNfAHKNSHIEKLCDgLAFDiYEKRLFKNGEPVNLSKKEMTLLT 162
Cdd:PRK15479  82 SAVADRVKGLNVGADDYLPKPFELEELDARLRALLRRS-AGQVQEVQQLGE-LIFH-DEGYFLLQGQPLALTPREQALLT 158

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 501056953 163 LLLQKKNKSVSREEIYSAVWDIDEMPSELSLRVYIRNLR-KIFGKH--IVSISKVGYS 217
Cdd:PRK15479 159 VLMYRRTRPVSRQQLFEQVFSLNDEVSPESIELYIHRLRkKLQGSDvrITTLRGLGYV 216
PhoB TIGR02154
phosphate regulon transcriptional regulatory protein PhoB; PhoB is a DNA-binding response ...
 3-202 1.95e-18

phosphate regulon transcriptional regulatory protein PhoB; PhoB is a DNA-binding response regulator protein acting with PhoR in a 2-component system responding to phosphate ion. PhoB acts as a positive regulator of gene expression for phosphate-related genes such as phoA, phoS, phoE and ugpAB as well as itself. It is often found proximal to genes for the high-affinity phosphate ABC transporter (pstSCAB; GenProp0190) and presumably regulates these as well. [Regulatory functions, DNA interactions, Signal transduction, Two-component systems]


Pssm-ID: 131209 [Multi-domain]  Cd Length: 226  Bit Score: 80.45  E-value: 1.95e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953    3 RILVLEDENMLNEMICDFLVANHFEVKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRK--SGKNTPCIFTT 80
Cdd:TIGR02154   4 RILVVEDEPAIRELIAYNLEKAGYDVVEAGDGDEALTLINERGPDLILLDWMLPGTSGIELCRRLRRrpETRAIPIIMLT 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   81 SLNDINDLNKGFLSGCDDYLKKPFELAELLLRINNLLRRNFAHKNSHIEKLcDGLAFDIYEKRLFKNGEPVNLSKKEMTL 160
Cdd:TIGR02154  84 ARGEEEDRVRGLETGADDYITKPFSPRELLARIKAVLRRIRPQLSDEVIEV-GDLSLDPVAHRVFRGGQPLSLGPTEFRL 162

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 501056953  161 LTLLLQKKNKSVSREEIYSAVWDIDEMPSELSLRVYIRNLRK 202
Cdd:TIGR02154 163 LHFFMTHPERVYSREQLLDRVWGRDVYVEERTVDVHIRRLRK 204
REC_OmpR_CusR-like cd19935
phosphoacceptor receiver (REC) domain of CusR-like OmpR family response regulators; ...
 4-103 2.47e-18

phosphoacceptor receiver (REC) domain of CusR-like OmpR family response regulators; Escherichia coli CusR is part of the CusS/CusR two-component system (TCS) that is involved in response to copper and silver. Other members of this subfamily include Escherichia coli PcoR, Pseudomonas syringae CopR, and Streptomyces coelicolor CutR, which are all transcriptional regulatory proteins and components of TCSs that regulate genes involved in copper resistance and/or metabolism. member of the subfamily is Escherichia coli HprR (hydrogen peroxide response regulator), previously called YdeW, which is part of the HprSR (or YedVW) TCS involved in stress response to hydrogen peroxide, as well as Cupriavidus metallidurans CzcR, which is part of the CzcS/CzcR TCS involved in the control of cobalt, zinc, and cadmium homeostasis. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381162 [Multi-domain]  Cd Length: 100  Bit Score: 76.71  E-value: 2.47e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   4 ILVLEDENMLNEMICDFLVANHFEVKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRKSGKNTPCIFTTSLN 83
Cdd:cd19935    1 ILVVEDEKKLAEYLKKGLTEEGYAVDVAYDGEDGLHLALTNEYDLIILDVMLPGLDGLEVLRRLRAAGKQTPVLMLTARD 80

                         90       100
                 ....*....|....*....|
gi 501056953  84 DINDLNKGFLSGCDDYLKKP 103
Cdd:cd19935   81 SVEDRVKGLDLGADDYLVKP 100
PRK11517 PRK11517
DNA-binding response regulator HprR;
3-219 4.24e-18

DNA-binding response regulator HprR;


Pssm-ID: 183172 [Multi-domain]  Cd Length: 223  Bit Score: 79.56  E-value: 4.24e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   3 RILVLEDENMLNEMICDFLVANHFEVKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRkSGKNTPCIFTTSL 82
Cdd:PRK11517   2 KILLIEDNQRTQEWVTQGLSEAGYVIDAVSDGRDGLYLALKDDYALIILDIMLPGMDGWQILQTLR-TAKQTPVICLTAR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953  83 NDINDLNKGFLSGCDDYLKKPFELAELLLRINNLLRRNFAHkNSHIEklCDGLAFDIYEKRLFKNGEPVNLSKKEMTLLT 162
Cdd:PRK11517  81 DSVDDRVRGLDSGANDYLVKPFSFSELLARVRAQLRQHHAL-NSTLE--ISGLRMDSVSQSVSRDNISITLTRKEFQLLW 157

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 501056953 163 LLLQKKNKSVSREEIYSAVWDIDEMPSELSLRVYIRNLRKIFG-----KHIVSISKVGYSYV 219
Cdd:PRK11517 158 LLASRAGEIIPRTVIASEIWGINFDSDTNTVDVAIRRLRAKVDdpfpeKLIATIRGMGYSFV 219
orf27 CHL00148
Ycf27; Reviewed
 3-201 6.30e-18

Ycf27; Reviewed


Pssm-ID: 214376 [Multi-domain]  Cd Length: 240  Bit Score: 79.38  E-value: 6.30e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   3 RILVLEDENMLNEMICDFLVANHFEVKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRKSgKNTPCIFTTSL 82
Cdd:CHL00148   8 KILVVDDEAYIRKILETRLSIIGYEVITASDGEEALKLFRKEQPDLVILDVMMPKLDGYGVCQEIRKE-SDVPIIMLTAL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953  83 NDINDLNKGFLSGCDDYLKKPFELAE------LLLRINNLLRRNFAHKNSHIEKLcDGLAFDIYEKRLFKNGEPVNLSKK 156
Cdd:CHL00148  87 GDVSDRITGLELGADDYVVKPFSPKElearirSVLRRTNKKSFSSKIPNSSIIRI-GFLKIDLNKKQVYKNNERIRLTGM 165

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 501056953 157 EMTLLTLLLQKKNKSVSREEIYSAVWDIdEMPSELSLR---VYIRNLR 201
Cdd:CHL00148 166 EFSLLELLISKSGEIFSRATILKEVWGY-TPERHIDTRvvdVHISRLR 212
PRK09836 PRK09836
DNA-binding transcriptional activator CusR; Provisional
 3-216 8.48e-18

DNA-binding transcriptional activator CusR; Provisional


Pssm-ID: 182102 [Multi-domain]  Cd Length: 227  Bit Score: 78.81  E-value: 8.48e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   3 RILVLEDENMLNEMICDFLVANHFEVKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRKSGKNTPCIFTTSL 82
Cdd:PRK09836   2 KLLIVEDEKKTGEYLTKGLTEAGFVVDLADNGLNGYHLAMTGDYDLIILDIMLPDVNGWDIVRMLRSANKGMPILLLTAL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953  83 NDINDLNKGFLSGCDDYLKKPFELAELLLRINNLLRRNFAHKNSHIEKLCDgLAFDIYEKRLFKNGEPVNLSKKEMTLLT 162
Cdd:PRK09836  82 GTIEHRVKGLELGADDYLVKPFAFAELLARVRTLLRRGAAVIIESQFQVAD-LMVDLVSRKVTRSGTRITLTSKEFTLLE 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 501056953 163 LLLQKKNKSVSREEIYSAVWDIDEMPSELSLRVYIRNLR-KIFG----KHIVSISKVGY 216
Cdd:PRK09836 161 FFLRHQGEVLPRSLIASQVWDMNFDSDTNAIDVAVKRLRgKIDNdfepKLIQTVRGVGY 219
REC_OmpR_MtPhoP-like cd17615
phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; ...
 3-108 1.55e-17

phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; Mycobacterium tuberculosis PhoP (MtPhoP) is part of the PhoP/PhoR two-component system that is involved in phosphate control by stimulating expression of genes involved in scavenging, transport and mobilization of phosphate, and repressing the utilization of nitrogen sources. Also included in this subfamily is Mycobacterium tuberculosis transcriptional regulatory protein TcrX, part of the two-component regulatory system TcrY/TcrX that may be involved in virulence. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381131 [Multi-domain]  Cd Length: 118  Bit Score: 75.08  E-value: 1.55e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   3 RILVLEDENMLNEMICDFLVANHFEVKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRKSGKNTPCIFTTSL 82
Cdd:cd17615    1 RVLVVDDEPNITELLSMALRYEGWDVETAADGAEALAAAREFRPDAVVLDIMLPDMDGLEVLRRLRADGPDVPVLFLTAK 80

                         90       100
                 ....*....|....*....|....*.
gi 501056953  83 NDINDLNKGFLSGCDDYLKKPFELAE 108
Cdd:cd17615   81 DSVEDRIAGLTAGGDDYVTKPFSLEE 106
trans_reg_C cd00383
DNA-binding effector domain of two-component system response regulators; Bacteria and some ...
 135-216 4.39e-16

DNA-binding effector domain of two-component system response regulators; Bacteria and some eukaryotes use two-component signal transduction systems to detect and respond to changes in the environment. The systems consists of a sensor histidine kinase and a response regulator. The former autophosphorylates a histidine residue on detecting an external stimulus. The phosphate is then transferred to an invariant aspartate residue in a highly conserved receiver domain of the response regulator. Phosphorylation activates a variable effector domain of the response regulator, which triggers the cellular response. This C-terminal effector domain belongs to the winged helix-turn-helix family of transcriptional regulators and contains DNA and RNA polymerase binding sites. Several dimers or monomers bind head to tail to small tandem repeats upstream of the genes. The RNA polymerase binding sites interact with the alpha or sigma subunit of RNA polymerase.


Pssm-ID: 294013 [Multi-domain]  Cd Length: 89  Bit Score: 70.59  E-value: 4.39e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953 135 LAFDIYEKRLFKNGEPVNLSKKEMTLLTLLLQKKNKSVSREEIYSAVWDIDEMPSELSLRVYIRNLRKIFGK-----HIV 209
Cdd:cd00383    1 LRLDPARREVTVDGEEVELTPKEFELLELLARNPGRVVSREELLEAVWGYDYEVDDRTVDVHISRLRKKLEDdpeprLIK 80


                 ....*..
gi 501056953 210 SISKVGY 216
Cdd:cd00383   81 TVRGVGY 87
REC_OmpR_CpxR cd17623
phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is ...
 4-104 1.15e-15

phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is part of the CpxA/CpxR two-component regulatory system that mediates envelope stress responses that is key for virulence and antibiotic resistance in several Gram negative pathogens. CpxR is a transcription factor/response regulator that controls the expression of numerous genes, including those of the classical porins OmpF and OmpC. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381138 [Multi-domain]  Cd Length: 115  Bit Score: 70.03  E-value: 1.15e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   4 ILVLEDENMLNEMICDFLVANHFEVKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRKSgKNTPCIFTTSLN 83
Cdd:cd17623    1 ILLIDDDRELTELLTEYLEMEGFNVRAAHDGEQGLAALLEGSPDLVVLDVMLPKMNGLDVLKELRKT-SQVPVLMLTARG 79

                         90       100
                 ....*....|....*....|.
gi 501056953  84 DINDLNKGFLSGCDDYLKKPF 104
Cdd:cd17623   80 DDIDRILGLELGADDYLPKPF 100
REC_Ycf29 cd19927
phosphoacceptor receiver (REC) domain of probable transcriptional regulator Ycf29; Ycf29 is a ...
 4-103 3.08e-15

phosphoacceptor receiver (REC) domain of probable transcriptional regulator Ycf29; Ycf29 is a probable response regulator of a two-component system (TCS), typically consisting a sensor and a response regulator, that functions in adaptation to changing environments. Processes regulated by TCSs in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Ycf29 contains an N-terminal REC domain and a LuxR-type helix-turn-helix DNA-binding output domain. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381154 [Multi-domain]  Cd Length: 102  Bit Score: 68.56  E-value: 3.08e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   4 ILVLEDENMLNEMICDFLVANHFEVKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRKSGK--NTPCIFTTS 81
Cdd:cd19927    1 ILLVDDDPGIRLAVKDYLEDQGFTVIAASNGLEALDLLNQYIPDLIISDIIMPGVDGYSLLGKLRKNADfdTIPVIFLTA 80

                         90       100
                 ....*....|....*....|..
gi 501056953  82 LNDINDLNKGFLSGCDDYLKKP 103
Cdd:cd19927   81 KGMTSDRIKGYNAGCDGYLSKP 102
REC_OmpR_PhoB cd17618
phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The ...
 2-108 4.20e-15

phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The transcription factor PhoB is a component of the PhoR/PhoB two-component system, a key regulatory protein network that facilitates response to inorganic phosphate (Pi) starvation conditions by turning on the phosphate (pho) regulon whose products are involved in phosphorus uptake and metabolism. PhoB is a member of the OmpR family of DNA-binding response regulators that contains REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381133 [Multi-domain]  Cd Length: 118  Bit Score: 68.82  E-value: 4.20e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   2 NRILVLEDENMLNEMICDFLVANHFEVKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRKS--GKNTPCIFT 79
Cdd:cd17618    1 RTILIVEDEPAIREMIAFNLERAGFDVVEAEDAESAVNLIVEPRPDLILLDWMLPGGSGIQFIRRLKRDemTRDIPIIML 80

                         90       100
                 ....*....|....*....|....*....
gi 501056953  80 TSLNDINDLNKGFLSGCDDYLKKPFELAE 108
Cdd:cd17618   81 TARGEEEDKVRGLEAGADDYITKPFSPRE 109
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 4-108 3.74e-14

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 66.02  E-value: 3.74e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953    4 ILVLEDENMLNEMICDFLVANHFEVKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRKSGKNTPCIFTTSLN 83
Cdd:pfam00072   1 VLIVDDDPLIRELLRQLLEKEGYVVAEADDGKEALELLKEERPDLILLDINMPGMDGLELLKRIRRRDPTTPVIILTAHG 80

                          90       100
                  ....*....|....*....|....*
gi 501056953   84 DINDLNKGFLSGCDDYLKKPFELAE 108
Cdd:pfam00072  81 DEDDAVEALEAGADDFLSKPFDPDE 105
REC_OmpR_PrrA-like cd17627
phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The ...
 4-108 1.18e-13

phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The Mycobacterium tuberculosis PrrA is part of the PrrA/PrrB two-component system (TCS) that has been implicated in early intracellular multiplication and is essential for viability. Also included in this subfamily is Mycobacterium tuberculosis MprA, part of the MprAB TCS that regulates EspR, a key regulator of the ESX-1 secretion system, and is required for establishment and maintenance of persistent infection in a tissue- and stage-specific fashion. PrrA and MprA belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381142 [Multi-domain]  Cd Length: 116  Bit Score: 64.71  E-value: 1.18e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   4 ILVLEDENMLNEMICDFLVANHFEVKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRKSGKNTPCIFTTSLN 83
Cdd:cd17627    1 ILVVDDDRAVRESLRRSLRFEGYEVETAVDGAEALRVISGNRPDAVVLDVMMPRLDGLEVCRRLRAAGNDLPILVLTARD 80

                         90       100
                 ....*....|....*....|....*
gi 501056953  84 DINDLNKGFLSGCDDYLKKPFELAE 108
Cdd:cd17627   81 SVSDRVAGLDAGADDYLVKPFALEE 105
Trans_reg_C pfam00486
Transcriptional regulatory protein, C terminal;
148-216 1.47e-13

Transcriptional regulatory protein, C terminal;


Pssm-ID: 425712 [Multi-domain]  Cd Length: 77  Bit Score: 63.30  E-value: 1.47e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 501056953  148 GEPVNLSKKEMTLLTLLLQKKNKSVSREEIYSAVWDIDEMPSELSLRVYIRNLRKIFGK------HIVSISKVGY 216
Cdd:pfam00486   1 GEEVELTPKEFKLLELLAENPGRVVSREQLLEEVWGEDYDVDDNTVDVHISRLRKKLEDdprdprLIKTVRGVGY 75
YesN COG4753
Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding ...
 3-103 1.73e-13

Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443786 [Multi-domain]  Cd Length: 103  Bit Score: 64.02  E-value: 1.73e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   3 RILVLEDENMLNEMICDFLV--ANHFEVKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRKSGKNTPCIFTT 80
Cdd:COG4753    1 KVLIVDDEPLIREGLKRILEweAGFEVVGEAENGEEALELLEEHKPDLVITDINMPGMDGLELLEAIRELDPDTKIIILS 80

                         90       100
                 ....*....|....*....|...
gi 501056953  81 SLNDINDLNKGFLSGCDDYLKKP 103
Cdd:COG4753   81 GYSDFEYAQEAIKLGADDYLLKP 103
PRK10336 PRK10336
two-component system response regulator QseB;
3-217 1.73e-13

two-component system response regulator QseB;


Pssm-ID: 182387 [Multi-domain]  Cd Length: 219  Bit Score: 66.84  E-value: 1.73e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   3 RILVLEDENMLNEMICDFLVANHFEVKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRKSGKNTPCIFTTSL 82
Cdd:PRK10336   2 RILLIEDDMLIGDGIKTGLSKMGFSVDWFTQGRQGKEALYSAPYDAVILDLTLPGMDGRDILREWREKGQREPVLILTAR 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953  83 NDINDLNKGFLSGCDDYLKKPFELAELLLRINNLLRRnfAHKNSHIEKLCDGLAFDIYEKRLFKNGEPVNLSKKEMTLLT 162
Cdd:PRK10336  82 DALAERVEGLRLGADDYLCKPFALIEVAARLEALMRR--TNGQASNELRHGNVMLDPGKRIATLAGEPLTLKPKEFALLE 159

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 501056953 163 LLLQKKNKSVSREEIYSAVWDIDEMPSELSLRVYIRNLRKIFGKH-IVSISKVGYS 217
Cdd:PRK10336 160 LLMRNAGRVLPRKLIEEKLYTWDEEVTSNAVEVHVHHLRRKLGSDfIRTVHGIGYT 215
REC_OmpR_EcPhoP-like cd19934
phosphoacceptor receiver (REC) domain of EcPhoP-like OmpR family response regulators; ...
 4-108 1.83e-13

phosphoacceptor receiver (REC) domain of EcPhoP-like OmpR family response regulators; Escherichia coli PhoP (EcPhoP) is part of the PhoQ/PhoP two-component system (TCS) that regulates virulence genes and plays an essential role in the response of the bacteria to the environment of their mammalian hosts, sensing several stimuli such as extracellular magnesium limitation, low pH, the presence of cationic antimicrobial peptides, and osmotic upshift. This subfamily also includes Brucella suis FeuP, part of the FeuPQ TCS that is involved in the regulation of iron uptake, and Microchaete diplosiphon RcaC, which is required for chromatic adaptation. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381161 [Multi-domain]  Cd Length: 117  Bit Score: 64.23  E-value: 1.83e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   4 ILVLEDENMLNEMICDFLVANHFEVKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRKSGKNTPCIFTTSLN 83
Cdd:cd19934    1 LLLVEDDALLAAQLKEQLSDAGYVVDVAEDGEEALFQGEEEPYDLVVLDLGLPGMDGLSVLRRWRSEGRATPVLILTARD 80

                         90       100
                 ....*....|....*....|....*
gi 501056953  84 DINDLNKGFLSGCDDYLKKPFELAE 108
Cdd:cd19934   81 SWQDKVEGLDAGADDYLTKPFHIEE 105
REC_OmpR_CtrA cd17616
phosphoacceptor receiver (REC) domain of CtrA-like OmpR family response regulators; CtrA is ...
 4-108 3.94e-13

phosphoacceptor receiver (REC) domain of CtrA-like OmpR family response regulators; CtrA is part of the CckA-ChpT-CtrA phosphorelay that is conserved in alphaproteobacteria and is important in orchestrating the cell cycle, polar development, and flagellar biogenesis. CtrA is the master regulator of flagella synthesis genes and also regulates genes involved in the cell cycle, exopolysaccharide synthesis, and cyclic-di-GMP signaling. CtrA is active as a transcription factor when phosphorylated. It is a member of the OmpR family of DNA-binding response regulators, characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381132 [Multi-domain]  Cd Length: 114  Bit Score: 63.58  E-value: 3.94e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   4 ILVLEDENMLNEMICDFLVANHFEVKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRKSGKNTPCIFTTSLN 83
Cdd:cd17616    1 VLLIEDDSATAQSIELMLKSEGFNVYTTDLGEEGLDLGKLYDYDIILLDLNLPDMSGYEVLRTLRLAKVKTPILILSGLA 80

                         90       100
                 ....*....|....*....|....*
gi 501056953  84 DINDLNKGFLSGCDDYLKKPFELAE 108
Cdd:cd17616   81 DIEDKVKGLGFGADDYMTKPFHKDE 105
Trans_reg_C smart00862
Transcriptional regulatory protein, C terminal; This domain is almost always found associated ...
 148-216 1.36e-12

Transcriptional regulatory protein, C terminal; This domain is almost always found associated with the response regulator receiver domain. It may play a role in DNA binding.


Pssm-ID: 214866 [Multi-domain]  Cd Length: 76  Bit Score: 61.03  E-value: 1.36e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 501056953   148 GEPVNLSKKEMTLLTLLLQKKNKSVSREEIYSAVWDIDEMPSELSLRVYIRNLRKIFGK-----HIVSISKVGY 216
Cdd:smart00862   1 GEPIKLTPKEFRLLELLLRNPGRVVSREELLEAVWGDDEDVDDNTLDVHISRLRKKLEDdgdprLIETVRGVGY 74
REC_D1_PleD-like cd17538
first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar ...
 3-104 1.58e-12

first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar domains; PleD contains a REC domain (D1) with the phosphorylatable aspartate, a REC-like adaptor domain (D2), and the enzymatic diguanylate cyclase (DGC) domain, also called the GGDEF domain according to a conserved sequence motif, as its output domain. The GGDEF-containing PleD response regulators are global regulators of cell metabolism in some important human pathogens. This model describes D1 of PleD and similar domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381093 [Multi-domain]  Cd Length: 104  Bit Score: 61.36  E-value: 1.58e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   3 RILVLEDENMLNEMICDFLVANHFEVKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELrKSGKNT---PCIFT 79
Cdd:cd17538    1 KILVVDDEPANRELLEALLSAEGYEVLTADSGQEALALAEEELPDLILLDVMMPGMDGFEVCRRL-KEDPETrhiPVIMI 79

                         90       100
                 ....*....|....*....|....*
gi 501056953  80 TSLNDINDLNKGFLSGCDDYLKKPF 104
Cdd:cd17538   80 TALDDREDRIRGLEAGADDFLSKPI 104
REC_citrate_TCS cd19925
phosphoacceptor receiver (REC) domain of citrate family two-component system response ...
 3-108 3.74e-12

phosphoacceptor receiver (REC) domain of citrate family two-component system response regulators; This family includes Lactobacillus paracasei MaeR, Escherichia coli DcuR and DpiA, Klebsiella pneumoniae CitB, as well as Bacillus DctR, MalR, and CitT. These are all response regulators of two-component systems (TCSs) from the citrate family, and are involved in the transcriptional regulation of genes associated with L-malate catabolism (MaeRK), citrate-specific fermentation (DpiAB, CitAB), plasmid inheritance (DpiAB), anaerobic fumarate respiratory system (DcuRS), and malate transport/utilization (MalKR). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381152 [Multi-domain]  Cd Length: 118  Bit Score: 60.72  E-value: 3.74e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   3 RILVLEDENMLNEMICDFlVANH--FEVKST-KSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRKSGKNTPCIFT 79
Cdd:cd19925    2 NVLIVEDDPMVAEIHRAY-VEQVpgFTVIGTaGTGEEALKLLKERQPDLILLDIYLPDGNGLDLLRELRAAGHDVDVIVV 80

                         90       100
                 ....*....|....*....|....*....
gi 501056953  80 TSLNDINDLNKGFLSGCDDYLKKPFELAE 108
Cdd:cd19925   81 TAANDVETVREALRLGVVDYLIKPFTFER 109
REC_PA4781-like cd19920
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase PA4781 and similar ...
 4-104 4.40e-12

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase PA4781 and similar domains; Pseudomonas aeruginosa cyclic di-GMP phosphodiesterase PA4781 contains an N-terminal REC domain and a C-terminal catalytic HD-GYP domain, characteristics of RpfG family response regulators. PA4781 is involved in cyclic di-3',5'-GMP (c-di-GMP) hydrolysis/degradation in a two-step reaction via the linear intermediate pGpG to produce GMP. Its unphosphorylated REC domain prevents accessibility of c-di-GMP to the active site. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381147 [Multi-domain]  Cd Length: 103  Bit Score: 60.22  E-value: 4.40e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   4 ILVLED--ENMlnEMICDFLVANHFEVKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRK--SGKNTPCIFT 79
Cdd:cd19920    1 ILIVDDvpDNL--RLLSELLRAAGYRVLVATDGQQALQRAQAEPPDLILLDVMMPGMDGFEVCRRLKAdpATRHIPVIFL 78

                         90       100
                 ....*....|....*....|....*
gi 501056953  80 TSLNDINDLNKGFLSGCDDYLKKPF 104
Cdd:cd19920   79 TALTDTEDKVKGFELGAVDYITKPF 103
REC_OmpR_MtrA-like cd17626
phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is ...
 3-108 5.38e-12

phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is part of MtrA/MtrB (or MtrAB), a highly conserved two-component system (TCS) implicated in the regulation of cell division in the actinobacteria. In unicellular Mycobacterium tuberculosis, MtrAB coordinates DNA replication with cell division and regulates the transcription of resuscitation-promoting factor B. In filamentous Streptomyces venezuelae, it links antibiotic production to sporulation. MtrA belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381141 [Multi-domain]  Cd Length: 115  Bit Score: 60.56  E-value: 5.38e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   3 RILVLEDENMLNEMICDFLVANHFEVKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRKSgKNTPCIFTTSL 82
Cdd:cd17626    2 RILVVDDDAALAEMIGIVLRGEGFDPAFCGDGTQALAAFREVRPDLVLLDLMLPGIDGIEVCRQIRAE-SGVPIVMLTAK 80

                         90       100
                 ....*....|....*....|....*.
gi 501056953  83 NDINDLNKGFLSGCDDYLKKPFELAE 108
Cdd:cd17626   81 SDTVDVVLGLESGADDYVAKPFKPKE 106
CadC1 COG3710
DNA-binding winged helix-turn-helix (wHTH) domain [Transcription];
137-220 3.71e-11

DNA-binding winged helix-turn-helix (wHTH) domain [Transcription];


Pssm-ID: 442924 [Multi-domain]  Cd Length: 106  Bit Score: 57.99  E-value: 3.71e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953 137 FDIYEKRLFKNGEPVNLSKKEMTLLTLLLQKKNKSVSREEIYSAVWDiDEMPSELSLRVYIRNLRKIFGK------HIVS 210
Cdd:COG3710   10 LDPARRELLRDGEPVRLSPRAFDLLLLLLEHPGRVVSRDELLAAVWP-GRVVSDNSLTQAISRLRKALGDdgleprLIRT 88

                         90
                 ....*....|
gi 501056953 211 ISKVGYSYVV 220
Cdd:COG3710   89 VPRRGYRLVA 98
REC_OmpR_ArcA_TorR-like cd17619
phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; ...
 3-108 1.03e-10

phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; This subfamily includes Escherichia coli TorR and ArcA, both OmpR family response regulators that mediate adaptation to changes in various respiratory growth conditions. The TorS-TorR two-component system (TCS) is responsible for the tight regulation of the torCAD operon, which encodes the trimethylamine N-oxide (TMAO) reductase respiratory system in response to anaerobic conditions and the presence of TMAO. The ArcA-ArcB TCS is involved in cell growth during anaerobiosis. ArcA is a global regulator that controls more than 30 operons involved in redox regulation (the Arc modulon). OmpR family DNA-binding response regulators are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381134 [Multi-domain]  Cd Length: 113  Bit Score: 57.01  E-value: 1.03e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   3 RILVLEDENMLNEMICDFLVANHFEVKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRKSGkNTPCIFTTSL 82
Cdd:cd17619    2 HILIVEDEPVTRATLKSYFEQEGYDVSEAGDGEEMRQILARQDIDLVLLDINLPGKDGLSLTRELREQS-EVGIILVTGR 80

                         90       100
                 ....*....|....*....|....*.
gi 501056953  83 NDINDLNKGFLSGCDDYLKKPFELAE 108
Cdd:cd17619   81 DDEVDRIVGLEIGADDYVTKPFNPRE 106
REC_OmpR_kpRstA-like cd17622
phosphoacceptor receiver (REC) domain of kpRstA-like OmpR family response regulators; ...
 2-105 1.65e-10

phosphoacceptor receiver (REC) domain of kpRstA-like OmpR family response regulators; Klebsiella pneumoniae RstA (kpRstA) is part of the RstA/RstB two-component regulatory system that may play a regulatory role in virulence. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381137 [Multi-domain]  Cd Length: 116  Bit Score: 56.62  E-value: 1.65e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   2 NRILVLEDENMLNEMICDFLVANHFEVKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRKSgKNTPCIFTTS 81
Cdd:cd17622    1 TRILLVEDDPKLARLIADFLESHGFNVVVEHRGDRALEVIAREKPDAVLLDIMLPGIDGLTLCRDLRPK-YQGPILLLTA 79

                         90       100
                 ....*....|....*....|....
gi 501056953  82 LNDINDLNKGFLSGCDDYLKKPFE 105
Cdd:cd17622   80 LDSDIDHILGLELGADDYVVKPVE 103
MtrAB_MtrA NF040689
MtrAB system response regulator MtrA;
4-182 1.89e-10

MtrAB system response regulator MtrA;


Pssm-ID: 468653 [Multi-domain]  Cd Length: 219  Bit Score: 58.34  E-value: 1.89e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   4 ILVLEDENMLNEMICDFLVANHFEVKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRKSgKNTPCIFTTSLN 83
Cdd:NF040689   1 ILVVDDDPALAEMLGIVLRAEGFETVFCADGAEAVEAFREVRPDLVLLDLMLPGMDGIEVCRQIRAE-SGVPIIMLTAKS 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953  84 DINDLNKGFLSGCDDYLKKPFELAELLLRINNLLRRNFAHKNSHIEklCDGLAFDIYEKRLFKNGEPVNLSKKEMTLLTL 163
Cdd:NF040689  80 DTVDVVRGLEAGADDYVVKPFKPKELVARIRARLRRSEDEESEVLR--IGDLTIDVAGHEVTRGGEEIPLTPLEFDLLVA 157

                        170
                 ....*....|....*....
gi 501056953 164 LLQKKNKSVSREEIYSAVW 182
Cdd:NF040689 158 LARKPGQVFSREELLEQVW 176
PRK10955 PRK10955
envelope stress response regulator transcription factor CpxR;
1-202 2.79e-10

envelope stress response regulator transcription factor CpxR;


Pssm-ID: 182864 [Multi-domain]  Cd Length: 232  Bit Score: 57.89  E-value: 2.79e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   1 MNRILVLEDENMLNEMICDFLVANHFEVKSTKSYNEALDLaYEQNFDLWIFDVKIIGGNGFKLLDELRKSgKNTPCIFTT 80
Cdd:PRK10955   1 MNKILLVDDDRELTSLLKELLEMEGFNVIVAHDGEQALDL-LDDSIDLLLLDVMMPKKNGIDTLKELRQT-HQTPVIMLT 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953  81 SLNDINDLNKGFLSGCDDYLKKPFELAELLLR------INNLLRRNFAHKNSHIEKLCDGLAFDIYEKRLFKNGEPVNLS 154
Cdd:PRK10955  79 ARGSELDRVLGLELGADDYLPKPFNDRELVARirailrRSHWSEQQQNNDNGSPTLEVDALSLNPGRQEASFDGQTLELT 158

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 501056953 155 KKEMTLLTLLLQKKNKSVSREEIYSAVWDIDEMPSELSLRVYIRNLRK 202
Cdd:PRK10955 159 GTEFTLLYLLAQHLGQVVSREHLSQEVLGKRLTPFDRAIDMHISNLRR 206
PRK10766 PRK10766
two-component system response regulator TorR;
3-201 3.29e-10

two-component system response regulator TorR;


Pssm-ID: 182711 [Multi-domain]  Cd Length: 221  Bit Score: 57.74  E-value: 3.29e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   3 RILVLEDENMLNEMICDFLVANHFEVKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRkSGKNTPCIFTTSL 82
Cdd:PRK10766   4 HILVVEDEPVTRARLQGYFEQEGYTVSEAASGAGMREIMQNQHVDLILLDINLPGEDGLMLTRELR-SRSTVGIILVTGR 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953  83 NDINDLNKGFLSGCDDYLKKPFELAELL---------LRINNLLRRNFAHKNSHIEklCDGLAFDIYEKRLFKNGEPVNL 153
Cdd:PRK10766  83 TDSIDRIVGLEMGADDYVTKPLELRELLvrvknllwrISLARQAQPHAQEEDNCYR--FAGYCLNVSRRTLERNGEPIKL 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 501056953 154 SKKEMTLLTLLLQKKNKSVSREEIYSAVWDIDEMPSELSLRVYIRNLR 201
Cdd:PRK10766 161 TKAEYELLVAFVTNPGQVLSRERLLRMLSHRVENPNDRTIDVLIRRLR 208
COG4567 COG4567
DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains ...
 3-108 3.58e-10

DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443624 [Multi-domain]  Cd Length: 177  Bit Score: 56.85  E-value: 3.58e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   3 RILVLEDENMLNEMICDFLVANHFEVKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRKSGKNTPCIFTTsl 82
Cdd:COG4567    6 SLLLVDDDEAFARVLARALERRGFEVTTAASVEEALALLEQAPPDYAVLDLRLGDGSGLDLIEALRERDPDARIVVLT-- 83

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 501056953  83 ndindlnkGFLS----------GCDDYLKKPFELAE 108
Cdd:COG4567   84 --------GYASiataveaiklGADDYLAKPADADD 111
REC_OmpR_BaeR-like cd19938
phosphoacceptor receiver (REC) domain of BaeR-like OmpR family response regulators; BaeR is ...
 3-104 5.90e-10

phosphoacceptor receiver (REC) domain of BaeR-like OmpR family response regulators; BaeR is part of the BaeSR two-component system that is involved in regulating genes that confer multidrug and metal resistance. In Salmonella, BaeSR induces AcrD and MdtABC drug efflux systems, increasing multidrug and metal resistance. In Escherichia coli, BaeR stimulates multidrug resistance via mdtABC (multidrug transporter ABC, formerly known as yegMNO) genes, which encode a resistance-nodulation-cell division (RND) drug efflux system. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381165 [Multi-domain]  Cd Length: 114  Bit Score: 55.08  E-value: 5.90e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   3 RILVLEDENMLNEMICDFLVANHFEVKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRKSgKNTPCIFTTSL 82
Cdd:cd19938    1 RILIVEDEPKLAQLLIDYLRAAGYAPTLLAHGDQVLPYVRHTPPDLILLDLMLPGTDGLTLCREIRRF-SDVPIIMVTAR 79

                         90       100
                 ....*....|....*....|..
gi 501056953  83 NDINDLNKGFLSGCDDYLKKPF 104
Cdd:cd19938   80 VEEIDRLLGLELGADDYICKPY 101
PRK11361 PRK11361
acetoacetate metabolism transcriptional regulator AtoC;
2-108 6.82e-10

acetoacetate metabolism transcriptional regulator AtoC;


Pssm-ID: 183099 [Multi-domain]  Cd Length: 457  Bit Score: 57.94  E-value: 6.82e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   2 NRILVLEDENMLNEMICDFLVANHFEVKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRKSGKNTPCIFTTS 81
Cdd:PRK11361   5 NRILIVDDEDNVRRMLSTAFALQGFETHCANNGRTALHLFADIHPDVVLMDIRMPEMDGIKALKEMRSHETRTPVILMTA 84

                         90       100
                 ....*....|....*....|....*..
gi 501056953  82 LNDINDLNKGFLSGCDDYLKKPFELAE 108
Cdd:PRK11361  85 YAEVETAVEALRCGAFDYVIKPFDLDE 111
REC_typeB_ARR-like cd17584
phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and ...
 4-104 8.46e-10

phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and similar domains; Type-B ARRs (Arabidopsis response regulators) are a class of MYB-type transcription factors that act as major players in the transcriptional activation of cytokinin-responsive genes. They directly regulate the expression of type-A ARR genes and other downstream target genes. Cytokinin is a plant hormone implicated in many growth and development processes including shoot organogenesis, leaf senescence, sink/source relationships, vascular development, lateral bud release, and photomorphogenic development. Cytokinin signaling involves a phosphorelay cascade by histidine kinase receptors (AHKs), histidine phosphotransfer proteins (AHPs) and downstream ARRs. ARRs are divided into two groups, type-A and -B, according to their sequence and domain structure. Type-B ARRs contain a receiver (REC) domain and a large C-terminal extension that has characteristics of an effector or output domain, with a Myb-like DNA binding domain referred to as the GARP domain. The GARP domain is a motif specific to plant transcription factors. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381121 [Multi-domain]  Cd Length: 115  Bit Score: 54.56  E-value: 8.46e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   4 ILVLEDENMLNEMICDFLVANHFEVKSTKSYNEALDLAYEQ--NFDLWIFDVKIIGGNGFKLLDELRKSgKNTPCIFTTS 81
Cdd:cd17584    1 VLVVDDDPTCLAILKRMLLRCGYQVTTCTDAEEALSMLRENkdEFDLVITDVHMPDMDGFEFLELIRLE-MDLPVIMMSA 79

                         90       100
                 ....*....|....*....|...
gi 501056953  82 LNDINDLNKGFLSGCDDYLKKPF 104
Cdd:cd17584   80 DGSTSTVMKGLAHGACDYLLKPV 102
REC_RssB-like cd17555
phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; ...
 3-105 8.90e-10

phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; Pseudomonas aeruginosa RssB is an orphan atypical response regulator containing a REC domain and a PP2C-type protein phosphatase output domain. Its function is still unknown. Escherichia RssB, which is not included in this subfamily, is a ClpX adaptor protein which alters ClpX specificity by mediating a specific interaction between ClpX and the substrates such as RpoS, an RNA polymerase sigma factor. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381107 [Multi-domain]  Cd Length: 116  Bit Score: 54.51  E-value: 8.90e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   3 RILVLEDENMLNEMICDFLVANHFEVKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRKSGKNTPCIFTTSL 82
Cdd:cd17555    2 TILVIDDDEVVRESIAAYLEDSGFQVLQAADGRQGLELFRSEQPDLVLCDLRMPEMDGLEVLKQITKESPDTPVIVVSGA 81

                         90       100
                 ....*....|....*....|...
gi 501056953  83 NDINDLNKGFLSGCDDYLKKPFE 105
Cdd:cd17555   82 GVMSDAVEALRLGAWDYLTKPIE 104
REC_TrrA-like cd17554
phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and ...
 3-108 2.45e-09

phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and similar domains; Thermotoga maritima contains a two-component signal transduction system (TCS) composed of the ThkA sensory histidine kinase (HK) and its cognate response regulator (RR) TrrA; the specific function of the system is unknown. TCSs couple environmental stimuli to adaptive responses. TrrA is a stand-alone RR containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381106 [Multi-domain]  Cd Length: 113  Bit Score: 52.99  E-value: 2.45e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   3 RILVLEDENMLNEMICDFLVANHFEVKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRKSGKNTPCIFTTSL 82
Cdd:cd17554    2 KILVVDDEENIRELYKEELEDEGYEVVTAGNGEEALEKLESEDPDLVILDIKMPGMDGLETLRKIREKKPDLPVIICTAY 81

                         90       100
                 ....*....|....*....|....*.
gi 501056953  83 NDINDLNKGFLSgcDDYLKKPFELAE 108
Cdd:cd17554   82 SEYKSDFSSWAA--DAYVVKSSDLTE 105
REC_OmpR_ChvI-like cd19936
phosphoacceptor receiver (REC) domain of ChvI-like OmpR family response regulators; ...
 4-103 2.95e-09

phosphoacceptor receiver (REC) domain of ChvI-like OmpR family response regulators; Sinorhizobium meliloti ChvI is part of the ExoS/ChvI two-component regulatory system (TCS) that is required for nitrogen-fixing symbiosis and exopolysaccharide synthesis. ExoS/ChvI also play important roles in regulating biofilm formation, motility, nutrient utilization, and the viability of free-living bacteria. ChvI belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381163 [Multi-domain]  Cd Length: 99  Bit Score: 52.45  E-value: 2.95e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   4 ILVLEDENMLNEMICDFLVANHFEVKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRKsgKNT-PCIFTTSL 82
Cdd:cd19936    1 IALVDDDRNILTSVSMALEAEGFSVETYTDGASALDGLNARPPDLAILDIKMPRMDGMELLQRLRQ--KSTlPVIFLTSK 78

                         90       100
                 ....*....|....*....|.
gi 501056953  83 NDINDLNKGFLSGCDDYLKKP 103
Cdd:cd19936   79 DDEIDEVFGLRMGADDYITKP 99
LytT COG3279
DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction ...
 1-108 3.02e-09

DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction mechanisms];


Pssm-ID: 442510 [Multi-domain]  Cd Length: 235  Bit Score: 55.21  E-value: 3.02e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   1 MNRILVLEDENMLNEMICDFLVANHF--EVKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRKSGKNTPCIF 78
Cdd:COG3279    1 MMKILIVDDEPLARERLERLLEKYPDleVVGEASNGEEALELLEEHKPDLVFLDIQMPGLDGFELARQLRELDPPPPIIF 80

                         90       100       110
                 ....*....|....*....|....*....|..
gi 501056953  79 TTSLND--IndlnKGFLSGCDDYLKKPFELAE 108
Cdd:COG3279   81 TTAYDEyaL----EAFEVNAVDYLLKPIDEER 108
REC_DivK-like cd17548
phosphoacceptor receiver (REC) domain of DivK and similar proteins; Caulobacter crescentus ...
 3-108 3.18e-09

phosphoacceptor receiver (REC) domain of DivK and similar proteins; Caulobacter crescentus DivK is an essential response regulator that is involved in the complex phosphorelay pathways controlling both cell division and motility. It localizes cell cycle regulators to specific poles of the cell during division. DivK contains a stand-alone REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381100 [Multi-domain]  Cd Length: 115  Bit Score: 52.93  E-value: 3.18e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   3 RILVLEDENMLNEMICDFLVANHFEVKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRK--SGKNTPCIFTT 80
Cdd:cd17548    1 KILIVEDNPLNMKLARDLLESAGYEVLEAADGEEALEIARKEKPDLILMDIQLPGMDGLEATRLLKEdpATRDIPVIALT 80

                         90       100
                 ....*....|....*....|....*...
gi 501056953  81 SLNDINDLNKGFLSGCDDYLKKPFELAE 108
Cdd:cd17548   81 AYAMKGDREKILEAGCDGYISKPIDTRE 108
PRK10529 PRK10529
DNA-binding transcriptional activator KdpE; Provisional
 1-219 3.56e-09

DNA-binding transcriptional activator KdpE; Provisional


Pssm-ID: 182522 [Multi-domain]  Cd Length: 225  Bit Score: 54.81  E-value: 3.56e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   1 MNRILVLEDENMLNEMICDFLVANHFEVKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRKSGKnTPCIFTT 80
Cdd:PRK10529   1 MTNVLIVEDEQAIRRFLRTALEGDGMRVFEAETLQRGLLEAATRKPDLIILDLGLPDGDGIEFIRDLRQWSA-IPVIVLS 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953  81 SLNDINDLNKGFLSGCDDYLKKPFELAE-LLLRINNLLRRNFAHKNSHIEKLCDgLAFDIYEKRLFKNGEPVNLSKKEMT 159
Cdd:PRK10529  80 ARSEESDKIAALDAGADDYLSKPFGIGElQARLRVALRRHSATPAPDPLVKFSD-VTVDLAARVIHRGEEEVHLTPIEFR 158

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 501056953 160 LLTLLLQKKNKSVSREEIYSAVWDIDEMPSELSLRVYIRNLRKIFG------KHIVSISKVGYSYV 219
Cdd:PRK10529 159 LLAVLLNNAGKVLTQRQLLNQVWGPNAVEHSHYLRIYMGHLRQKLEqdparpRHFITETGIGYRFM 224
REC_OmpR_YycF-like cd17614
phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF ...
 4-108 3.81e-09

phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF appears to play an important role in cell wall integrity in a wide range of gram-positive bacteria, and may also modulate cell membrane integrity. It functions as part of a phosphotransfer system that ultimately controls the levels of competence within the bacteria. YycF belongs to the OmpR family of response regulators, which are characterized by a REC domain and a winged helix-turn-helix effector domain involved in DNA binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381130 [Multi-domain]  Cd Length: 115  Bit Score: 52.81  E-value: 3.81e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   4 ILVLEDENMLNEMICDFLVANHFEVKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRKSgKNTPCIFTTSLN 83
Cdd:cd17614    1 ILVVDDEKPISDILKFNLTKEGYEVVTAYDGREALEKVEEEQPDLILLDLMLPEKDGLEVCREVRKT-SNVPIIMLTAKD 79

                         90       100
                 ....*....|....*....|....*
gi 501056953  84 DINDLNKGFLSGCDDYLKKPFELAE 108
Cdd:cd17614   80 SEVDKVLGLELGADDYVTKPFSNRE 104
ompR PRK09468
osmolarity response regulator; Provisional
 1-219 7.45e-09

osmolarity response regulator; Provisional


Pssm-ID: 181883 [Multi-domain]  Cd Length: 239  Bit Score: 54.21  E-value: 7.45e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   1 MNRILVLEDENMLNEMICDFLVANHFEVKSTKSyNEALD-LAYEQNFDLWIFDVKIIGGNGFKLLDELRKSGKNTPCIFT 79
Cdd:PRK09468   5 NYKILVVDDDMRLRALLERYLTEQGFQVRSAAN-AEQMDrLLTRESFHLMVLDLMLPGEDGLSICRRLRSQNNPTPIIML 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953  80 TSLNDINDLNKGFLSGCDDYLKKPFE----LAELLLRINNLLRRNFAHKNSHIEKLCDG-LAFDIYEKRLFKNGEPVNLS 154
Cdd:PRK09468  84 TAKGEEVDRIVGLEIGADDYLPKPFNprelLARIRAVLRRQAPELPGAPSQEEEVIAFGkFKLNLGTRELFRGDEPMPLT 163

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 501056953 155 KKEMTLLTLLLQKKNKSVSREEIYSAVWDIDEMPSELSLRVYIRNLRKIF------GKHIVSISKVGYSYV 219
Cdd:PRK09468 164 TGEFAVLKALVSHPREPLSRDKLMNLARGREYSAMERSIDVQISRLRRLIeedpahPRYIQTVWGLGYVFV 234
REC_HP-RR-like cd17573
phosphoacceptor receiver (REC) domain of orphan response regulator HP-RR and similar proteins; ...
 4-106 1.18e-08

phosphoacceptor receiver (REC) domain of orphan response regulator HP-RR and similar proteins; Helicobacter pylori response regulator hp1043 (HP-RR) is an orphan response regulator which is phosphorylation-independent and is essential for growth. HP-RR functions as a cell growth-associated regulator in the absence of post-translational modification. Members of this subfamily contain REC and DNA-binding output domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381115 [Multi-domain]  Cd Length: 110  Bit Score: 51.28  E-value: 1.18e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   4 ILVLEDENMLNEMICDFLVANHFEVKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRKSGKNTPCIFTTSLN 83
Cdd:cd17573    1 ILLIEDDSTLGKEISKGLNEKGYQADVAESLKDGEYYIDIRNYDLVLVSDKLPDGNGLSIVSRIKEKHPSIVVIVLSDNP 80

                         90       100
                 ....*....|....*....|...
gi 501056953  84 DINDLNKGFLSGCDDYLKKPFEL 106
Cdd:cd17573   81 KTEQEIEAFKEGADDYIAKPFDF 103
REC_OmpR_BfmR-like cd19939
phosphoacceptor receiver (REC) domain of BfmR-like OmpR family response regulators; ...
 3-105 1.36e-08

phosphoacceptor receiver (REC) domain of BfmR-like OmpR family response regulators; Acinetobacter baumannii BfmR is part of the BfmR/S two-component system that functions as the master regulator of biofilm initiation. BfmR confers resistance to complement-mediated bactericidal activity, independent of capsular polysaccharide, and also increases resistance to the clinically important antimicrobials meropenem and colistin, making it a potential antimicrobial target. Its inhibition would have the dual benefit of significantly decreasing in vivo survival and increasing sensitivity to selected antimicrobials. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381166 [Multi-domain]  Cd Length: 116  Bit Score: 51.22  E-value: 1.36e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   3 RILVLEDENMLNEMICDFLVANHFEVKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRKSGKnTPCIFTTSL 82
Cdd:cd19939    1 RILIVEDELELARLTRDYLIKAGLEVSVFTDGQRAVRRIIDEQPSLVVLDIMLPGMDGLTVCREVREHSH-VPILMLTAR 79

                         90       100
                 ....*....|....*....|...
gi 501056953  83 NDINDLNKGFLSGCDDYLKKPFE 105
Cdd:cd19939   80 TEEMDRVLGLEMGADDYLCKPFS 102
REC_OmpR_NsrR-like cd18159
phosphoacceptor receiver (REC) domain of Streptococcus agalactiae NsrR-like OmpR family ...
 4-107 1.88e-08

phosphoacceptor receiver (REC) domain of Streptococcus agalactiae NsrR-like OmpR family response regulators; Streptococcus agalactiae NsrR is a lantibiotic resistance-associated response regulator and is part of the nisin resistance operon. It is a member of the NsrRK two-component system (TCS) that is involved in the regulation of lantibiotic resistance genes such as a membrane-associated lipoprotein of LanI, and the nsr gene cluster which encodes for the resistance protein NSR and the ABC transporter NsrFP, both conferring resistance against nisin. This subfamily also includes Staphylococcus epidermidis GraR, part of the GraR/GraS TCS involved in resistance against cationic antimicrobial peptides, and Bacillus subtilis BceR, part of the BceS/BceR TCS involved in the regulation of bacitracin resistance. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381143 [Multi-domain]  Cd Length: 113  Bit Score: 50.74  E-value: 1.88e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   4 ILVLEDENMLNEMICDFLVANHFEVKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRKSgKNTPCIFTTSLN 83
Cdd:cd18159    1 ILIVEDDETIASLLKKHLEKWGYEVVLIEDFEDVLEEFLQFKPDLVLLDINLPYFDGFYWCREIRQI-SNVPIIFISSRD 79

                         90       100
                 ....*....|....*....|....
gi 501056953  84 DINDLNKGFLSGCDDYLKKPFELA 107
Cdd:cd18159   80 DNMDQVMAINMGGDDYITKPFDLD 103
resp_reg_YycF NF040534
response regulator YycF;
3-216 2.80e-08

response regulator YycF;


Pssm-ID: 439744 [Multi-domain]  Cd Length: 231  Bit Score: 52.42  E-value: 2.80e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   3 RILVLEDENMLNEMICDFLVANHFEVKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRKSgKNTPCIFTTSL 82
Cdd:NF040534   2 KILVVDDEKPIADILEFNLKKEGYEVFCAYDGNEALELVEEEVPDLVLLDIMLPGRDGMEVCREVRKK-YDMPIIMLTAK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953  83 NDINDLNKGFLSGCDDYLKKPFELAELLLRINNLLRRNFAHKNSHIEKLCDglafDIYEKRLF---------KNGEPVNL 153
Cdd:NF040534  81 DSEIDKVLGLELGADDYVTKPFSTRELIARVKANLRRHQQQNTEEEEEENN----EIVIGSLTihpdaytvkKRGETIEL 156

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 501056953 154 SKKEMTLLTLLLQKKNKSVSREEIYSAVWDIDEMPSELSLRVYIRNLR-KI-----FGKHIVSISKVGY 216
Cdd:NF040534 157 THREFELLHYLAKHIGQVMTREHLLQTVWGYDYFGDVRTVDVTVRRLReKIednpsHPEWIVTRRGVGY 225
REC_OmpR_BsPhoP-like cd19937
phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus ...
 5-108 3.52e-08

phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus subtilis PhoP (BsPhoP) is part of the PhoPR two-component system that participates in a signal transduction network that controls adaptation of the bacteria to phosphate deficiency by regulating (activating or repressing) genes of the Pho regulon upon phosphorylation by PhoR. When activated, PhoPR directs expression of phosphate scavenging enzymes, lowers synthesis of the phosphate-rich wall teichoic acid (WTA) and initiates synthesis of teichuronic acid, a non-phosphate containing replacement anionic polymer. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381164 [Multi-domain]  Cd Length: 116  Bit Score: 49.96  E-value: 3.52e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   5 LVLEDENMLNEMICDFLVANHFEVKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRKSGK--NTPCIFTTSL 82
Cdd:cd19937    1 LVVDDEEDIVELLKYNLEKEGYEVVTAYDGEEALKRAKDEKPDLIILDLMLPGIDGLEVCRILRSDPKtsSIPIIMLTAK 80

                         90       100
                 ....*....|....*....|....*.
gi 501056953  83 NDINDLNKGFLSGCDDYLKKPFELAE 108
Cdd:cd19937   81 GEEFDKVLGLELGADDYITKPFSPRE 106
PRK11083 PRK11083
DNA-binding response regulator CreB; Provisional
 1-201 1.19e-07

DNA-binding response regulator CreB; Provisional


Pssm-ID: 236838 [Multi-domain]  Cd Length: 228  Bit Score: 50.35  E-value: 1.19e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   1 MNRILVLEDENMLNEMICDFLVANHFEVKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRKSGKNTPCIFTT 80
Cdd:PRK11083   3 QPTILLVEDEQAIADTLVYALQSEGFTVEWFERGLPALDKLRQQPPDLVILDVGLPDISGFELCRQLLAFHPALPVIFLT 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953  81 SLNDINDLNKGFLSGCDDYLKKPF---ELAELLLRINNLlrrnfAHKNSHIEKLCDGLAFDIYE--KRLFKNGEPVNLSK 155
Cdd:PRK11083  83 ARSDEVDRLVGLEIGADDYVAKPFsprEVAARVRTILRR-----VKKFAAPSPVIRIGHFELDEpaARISYFGTPLTLTR 157

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 501056953 156 KEMTLLTLLLQKKNKSVSREEIYSAVWDIDEMPSELSLRVYIRNLR 201
Cdd:PRK11083 158 YEFLLLKTLLLSPGRVFSRQQLMDIVWEDAQDSYDRTVDTHIKTLR 203
REC_hyHK_CKI1_RcsC-like cd17546
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators ...
 4-108 1.97e-07

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators similar to Arabidopsis thaliana CKI1 and Escherichia coli RcsC; This family is composed of hybrid sensor histidine kinases/response regulators that are sensor histidine kinases (HKs) fused with a REC domain, similar to the sensor histidine kinase CKI1 from Arabidopsis thaliana, which is involved in multi-step phosphorelay (MSP) signaling that mediates responses to a variety of important stimuli in plants. MSP involves a signal being transferred from HKs via histidine phosphotransfer proteins (AHP1-AHP5) to nuclear response regulators. The CKI1 REC domain specifically interacts with the downstream signaling protein AHP2, AHP3 and AHP5. The plant MSP system has evolved from the prokaryotic two-component system (TCS), which allows organisms to sense and respond to changes in environmental conditions. This family also includes bacterial hybrid sensor HKs such as Escherichia coli RcsC, which is a component of the Rcs signalling pathway that controls a variety of physiological functions like capsule synthesis, cell division, and motility. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381099 [Multi-domain]  Cd Length: 113  Bit Score: 47.85  E-value: 1.97e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   4 ILVLEDeNMLNEMIC-DFLVANHFEVKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRK---SGKNTPCIFT 79
Cdd:cd17546    1 VLVVDD-NPVNRKVLkKLLEKLGYEVDVAENGQEALELLKEEPFDLVLMDLQMPVMDGLEATRRIRElegGGRRTPIIAL 79

                         90       100
                 ....*....|....*....|....*....
gi 501056953  80 TSLNDINDLNKGFLSGCDDYLKKPFELAE 108
Cdd:cd17546   80 TANALEEDREKCLEAGMDDYLSKPVKLDQ 108
REC_CheY4-like cd17562
phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY ...
 3-104 2.51e-07

phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY family proteins; CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY4 and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381110 [Multi-domain]  Cd Length: 118  Bit Score: 47.68  E-value: 2.51e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   3 RILVLEDENMLNEMICDFLVANHFEVKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRK--SGKNTPCIFTT 80
Cdd:cd17562    2 KILAVDDSASIRQMVSFTLRGAGYEVVEAADGRDALSKAQSKKFDLIITDQNMPNMDGIELIKELRKlpAYKFTPILMLT 81

                         90       100
                 ....*....|....*....|....
gi 501056953  81 SLNDINDLNKGFLSGCDDYLKKPF 104
Cdd:cd17562   82 TESSDEKKQEGKAAGATGWLVKPF 105
REC_PFxFATGY cd17586
phosphoacceptor receiver (REC) domain of PFxFATGY motif single-domain (stand-alone) response ...
 4-84 3.84e-07

phosphoacceptor receiver (REC) domain of PFxFATGY motif single-domain (stand-alone) response regulators; This subfamily is composed of stand-alone response regulators (RRs) containing the PFxFATG[G/Y] motif; RRs with such a motif are also called ''FAT GUY'' response regulators. Included in this subfamily are Sphingomonas melonis SdrG, Sinorhizobium meliloti Sma0114, and Erythrobacter litoralis EL_LovR. SdrG is involved in the control of the general stress response. Sma0114 is part of the Sma0113/Sma0114 two-component system (TCS) that is involved in catabolite repression and polyhydroxy butyrate synthesis. EL_LovR is involved in a light-regulated TCS. PFxFATG[G/Y] RRs are typically associated with histidine-tryptophan-glutamate (HWE) histidine kinases that constitute a subclass of the larger histidine kinase superfamily characterized by an altered ATP binding site, which lacks the F-box that is normally an integral component of the ATP lid. The PFxFATG[G/Y] motif is involved in conformational changes after phosphorylation that results in the activation of the RR. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381122 [Multi-domain]  Cd Length: 111  Bit Score: 47.08  E-value: 3.84e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   4 ILVLEDENMLNEMICDFL-VANHFEVKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRKSgkNTPCIFTTSL 82
Cdd:cd17586    1 VLVLEDEPLIAMNLEDALeDLGGKEVVTAATCAEALRSLADGPIDIAILDVNLGGETSIPVADALKRR--AIPFIFATGY 78


                 ..
gi 501056953  83 ND 84
Cdd:cd17586   79 GD 80
REC_2_DhkD-like cd17580
second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal ...
 4-108 4.09e-07

second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal transduction histidine kinase D and similar domains; Dictyostelium discoideum hybrid signal transduction histidine kinase D (DhkD) is a large protein that contains two histidine kinase (HK) and two REC domains on the intracellular side of a single pass transmembrane domain, and extracellular PAS and PAC domains that likely are involved in ligand binding. This model represents the second REC domain and similar domains. DhkD activates the cAMP phosphodiesterase RegA to ensure proper prestalk and prespore patterning, tip formation, and the vertical elongation of the mound into a finger, in Dictyostelium discoideum. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381118 [Multi-domain]  Cd Length: 112  Bit Score: 47.07  E-value: 4.09e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   4 ILVLEDENMLNEMICDFLVANHFEVKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRK--SGKNTPCIFTTS 81
Cdd:cd17580    1 ILVVDDNEDAAEMLALLLELEGAEVTTAHSGEEALEAAQRFRPDVILSDIGMPGMDGYELARRLRElpWLANTPAIALTG 80

                         90       100
                 ....*....|....*....|....*..
gi 501056953  82 LNDINDLNKGFLSGCDDYLKKPFELAE 108
Cdd:cd17580   81 YGQPEDRERALEAGFDAHLVKPVDPDE 107
REC_hyHK cd17598
phosphoacceptor receiver (REC) domain of uncharacterized hybrid sensor histidine kinase ...
 4-105 5.17e-07

phosphoacceptor receiver (REC) domain of uncharacterized hybrid sensor histidine kinase/response regulators; Typically, two-component regulatory systems (TCSs) consist of a sensor (histidine kinase) that responds to specific input(s) by modifying the output of a cognate response regulator (RR). TCSs allow organisms to sense and respond to changes in environmental conditions. Hybrid sensor histidine kinase/response regulators contain all the elements of a classical TCS in a single polypeptide chain. RRs share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381128 [Multi-domain]  Cd Length: 118  Bit Score: 46.94  E-value: 5.17e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   4 ILVLEDENMLNEMICDFLVANHFEVKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELR--KSGKNTPCIFTTS 81
Cdd:cd17598    1 ILIVEDSPTQAEQLKHILEEQGYKVQVARNGREALAMLAEHRPTLVISDIVMPEMDGYELCRKIKsdPDLKDIPVILLTT 80

                         90       100
                 ....*....|....*....|....
gi 501056953  82 LNDINDLNKGFLSGCDDYLKKPFE 105
Cdd:cd17598   81 LSDPRDVIRGLECGADNFITKPYD 104
PRK11173 PRK11173
two-component response regulator; Provisional
 3-104 8.72e-07

two-component response regulator; Provisional


Pssm-ID: 183013 [Multi-domain]  Cd Length: 237  Bit Score: 48.09  E-value: 8.72e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   3 RILVLEDENMLNEMICDFLVANHFEVKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRKSgKNTPCIFTTSL 82
Cdd:PRK11173   5 HILIVEDELVTRNTLKSIFEAEGYDVFEATDGAEMHQILSENDINLVIMDINLPGKNGLLLARELREQ-ANVALMFLTGR 83

                         90       100
                 ....*....|....*....|....
gi 501056953  83 NdiNDLNK--GFLSGCDDYLKKPF 104
Cdd:PRK11173  84 D--NEVDKilGLEIGADDYITKPF 105
REC_RpfG-like cd17551
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator ...
 3-108 1.13e-06

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator RpfG and similar proteins; Cyclic di-GMP phosphodiesterase response regulator RpfG, together with sensory/regulatory protein RpfC, constitute a two-component system implicated in sensing and responding to the diffusible signal factor (DSF) that is essential for cell-cell signaling. RpfC is a hybrid sensor/histidine kinase that phosphorylates and activates RpfG, which degrades cyclic di-GMP to GMP, leading to the activation of Clp, a global transcriptional regulator that regulates a large set of genes in the DSF pathway. RpfG contains a CheY-like receiver domain attached to a histidine-aspartic acid-glycine-tyrosine-proline (HD-GYP) cyclic di-GMP phosphodiesterase domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381103 [Multi-domain]  Cd Length: 118  Bit Score: 45.90  E-value: 1.13e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   3 RILVLEDeNMLNEMICDFLVANH--FEVKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRK--SGKNTPCIF 78
Cdd:cd17551    2 RILIVDD-NPTNLLLLEALLRSAgyLEVVSFTDPREALAWCRENPPDLILLDYMMPGMDGLEFIRRLRAlpGLEDVPIVM 80

                         90       100       110
                 ....*....|....*....|....*....|
gi 501056953  79 TTSLNDINDLNKGFLSGCDDYLKKPFELAE 108
Cdd:cd17551   81 ITADTDREVRLRALEAGATDFLTKPFDPVE 110
REC_OmpR_VirG cd17594
phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is ...
 4-108 1.40e-06

phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is part of the VirA/VirG two-component system that regulates the expression of virulence (vir) genes. The histidine kinase VirA senses a phenolic wound response signal, undergoes autophosphorylation, and phosphorelays to the VirG response regulator, which induces transcription of the vir regulon. VirG belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381125 [Multi-domain]  Cd Length: 113  Bit Score: 45.52  E-value: 1.40e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   4 ILVLEDENMLNEMICDFLVANHFEVKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRKSGKNTPCIFTTSLN 83
Cdd:cd17594    2 VLVVDDDAAMRHLLILYLRERGFDVTAAADGAEEARLMLHRRVDLVLLDLRLGQESGLDLLRTIRARSDVPIIIISGDRR 81

                         90       100
                 ....*....|....*....|....*
gi 501056953  84 DINDLNKGFLSGCDDYLKKPFELAE 108
Cdd:cd17594   82 DEIDRVVGLELGADDYLAKPFGLRE 106
REC_DC-like cd17534
phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; ...
 3-108 1.45e-06

phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; This groups includes a modulated diguanylate cyclase containing a PAS sensor domain from Desulfovibrio desulfuricans G20. Members of this group contain N-terminal REC domains and various output domains including the GGDEF, histidine kinase, and helix-turn-helix (HTH) DNA binding domains. Also included in this family is Mycobacterium tuberculosis PdtaR, a transcriptional antiterminator that contains a REC domain and an ANTAR RNA-binding output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381089 [Multi-domain]  Cd Length: 117  Bit Score: 45.48  E-value: 1.45e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   3 RILVLEDENMLNEMICDFLVANHFEV-KSTKSYNEALDLAYEQNFDLWIFDVKIIGG-NGFKLLDELRKSgKNTPCIFTT 80
Cdd:cd17534    2 KILIVEDEAIIALDLKEILESLGYEVvGIADSGEEAIELAEENKPDLILMDINLKGDmDGIEAAREIREK-FDIPVIFLT 80

                         90       100
                 ....*....|....*....|....*...
gi 501056953  81 SLNDINDLNKGFLSGCDDYLKKPFELAE 108
Cdd:cd17534   81 AYSDEETLERAKETNPYGYLVKPFNERE 108
REC_CheV-like cd19924
phosphoacceptor receiver (REC) domain of chemotaxis protein CheV and similar proteins; This ...
 4-103 1.85e-06

phosphoacceptor receiver (REC) domain of chemotaxis protein CheV and similar proteins; This subfamily includes the REC domains of Bacillus subtilis chemotaxis protein CheV, Myxococcus xanthus gliding motility regulatory protein FrzE, and similar proteins. CheV is a hybrid protein with an N-terminal CheW-like domain and a C-terminal CheY-like REC domain. The CheV pathway is one of three systems employed by B. subtilis for sensory adaptation that contribute to chemotaxis. It is involved in the transmission of sensory signals from chemoreceptors to flagellar motors. Together with CheW, it is involved in the coupling of methyl-accepting chemoreceptors to the central two-component histidine kinase CheA. FrzE is a hybrid sensor histidine kinase/response regulator that is part of the Frz pathway that controls cell reversal frequency to support directional motility during swarming and fruiting body formation. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381151 [Multi-domain]  Cd Length: 111  Bit Score: 45.06  E-value: 1.85e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   4 ILVLEDENMLNEMICDFLVANHFEVKSTKSYNEALDL---------AYEQNFDLWIFDVKIIGGNGFKLLDELRKSGK-- 72
Cdd:cd19924    1 ILVVDDSPTARKQLRDLLKNLGFEIAEAVDGEEALNKlenlakegnDLSKELDLIITDIEMPKMDGYELTFELRDDPRla 80

                         90       100       110
                 ....*....|....*....|....*....|.
gi 501056953  73 NTPCIFTTSLNDINDLNKGFLSGCDDYLKKP 103
Cdd:cd19924   81 NIPVILNSSLSGEFSRARGKKVGADAYLAKF 111
REC_2_GGDEF cd17544
second phosphoacceptor receiver (REC) domain of uncharacterized GGDEF domain proteins; This ...
 3-105 1.89e-06

second phosphoacceptor receiver (REC) domain of uncharacterized GGDEF domain proteins; This family is composed of uncharacterized PleD-like response regulators that contain two N-terminal REC domains and a C-terminal diguanylate cyclase output domain with the characteristic GGDEF motif at the active site. Unlike PleD which contains a REC-like adaptor domain, the second REC domain of these uncharacterized GGDEF domain proteins, described in this model, contains characteristic metal-binding and active site residues. PleD response regulators are global regulators of cell metabolism in some important human pathogens. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381098 [Multi-domain]  Cd Length: 122  Bit Score: 45.59  E-value: 1.89e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   3 RILVLEDENMLNEMICDFLVANHFEVKSTKSYNEALDLaYEQNFD--LWIFDVKIIGGNGFKLLDELRKS-GKNTPCIFT 79
Cdd:cd17544    2 KVLVVDDSATSRNHLRALLRRHNFQVLEAANGQEALEV-LEQHPDikLVITDYNMPEMDGFELVREIRKKySRDQLAIIG 80

                         90       100
                 ....*....|....*....|....*..
gi 501056953  80 TSLNDINDLNKGFL-SGCDDYLKKPFE 105
Cdd:cd17544   81 ISASGDNALSARFIkAGANDFLTKPFL 107
PRK10710 PRK10710
DNA-binding transcriptional regulator BaeR; Provisional
 3-104 3.81e-06

DNA-binding transcriptional regulator BaeR; Provisional


Pssm-ID: 182665 [Multi-domain]  Cd Length: 240  Bit Score: 46.22  E-value: 3.81e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   3 RILVLEDENMLNEMICDFLVANHFEVKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRKSgKNTPCIFTTSL 82
Cdd:PRK10710  12 RILIVEDEPKLGQLLIDYLQAASYATTLLSHGDEVLPYVRQTPPDLILLDLMLPGTDGLTLCREIRRF-SDIPIVMVTAK 90

                         90       100
                 ....*....|....*....|..
gi 501056953  83 NDINDLNKGFLSGCDDYLKKPF 104
Cdd:PRK10710  91 IEEIDRLLGLEIGADDYICKPY 112
pleD PRK09581
response regulator PleD; Reviewed
 21-103 5.08e-06

response regulator PleD; Reviewed


Pssm-ID: 236577 [Multi-domain]  Cd Length: 457  Bit Score: 46.43  E-value: 5.08e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953  21 LVANHFEVKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELrKSGKNT---PCIFTTSLNDINDLNKGFLSGCD 97
Cdd:PRK09581  22 LLAEYYTVLTASSGAEAIAICEREQPDIILLDVMMPGMDGFEVCRRL-KSDPATthiPVVMVTALDDPEDRVRGLEAGAD 100


                 ....*.
gi 501056953  98 DYLKKP 103
Cdd:PRK09581 101 DFLTKP 106
REC_OmpR_RegX3-like cd17621
phosphoacceptor receiver (REC) domain of RegX3-like OmpR family response regulators; RegX3 is ...
 4-103 5.64e-06

phosphoacceptor receiver (REC) domain of RegX3-like OmpR family response regulators; RegX3 is a member of the SenX3-RegX3 two-component system that is involved in phosphate-sensing signal transduction. Phosphorylated RegX3 functions as a transcriptional activator of phoA. It induces transcription in phosphate limiting environment and also controls expression of several critical metabolic enzymes in aerobic condition. RegX3 belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381136 [Multi-domain]  Cd Length: 99  Bit Score: 43.73  E-value: 5.64e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   4 ILVLEDENMLNEMICDFLVANHFEVKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRKSgKNTPCIFTTSLN 83
Cdd:cd17621    1 VLVVEDEESFSDPLAYLLRKEGFEVTVATDGPAALAEFDRAGADIVLLDLMLPGLSGTEVCRQLRAR-SNVPVIMVTAKD 79

                         90       100
                 ....*....|....*....|
gi 501056953  84 DINDLNKGFLSGCDDYLKKP 103
Cdd:cd17621   80 SEIDKVVGLELGADDYVTKP 99
REC_OmpR_KdpE-like cd17620
phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a ...
 4-103 6.83e-06

phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a component of the KdpD/KdpE two-component system (TCS) and is activated when histidine kinase KdpD senses a drop in external K+ concentration or upshift in ionic osmolarity, resulting in the expression of a heterooligomeric transporter KdpFABC. In addition, the KdpD/KdpE TCS is also an adaptive regulator involved in the virulence and intracellular survival of pathogenic bacteria. KdpE is a member of the OmpR family of DNA-binding response regulators that contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381135 [Multi-domain]  Cd Length: 99  Bit Score: 43.31  E-value: 6.83e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   4 ILVLEDENMLNEMICDFLVANHFEVKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRkSGKNTPCIFTTSLN 83
Cdd:cd17620    1 ILVIEDEPQIRRFLRTALEAHGYRVFEAETGQEGLLEAATRKPDLIILDLGLPDMDGLEVIRRLR-EWSAVPVIVLSARD 79

                         90       100
                 ....*....|....*....|
gi 501056953  84 DINDLNKGFLSGCDDYLKKP 103
Cdd:cd17620   80 EESDKIAALDAGADDYLTKP 99
REC_RegA-like cd17563
phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; ...
 2-108 1.40e-05

phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; Rhodobacter sphaeroides RegA, also called response regulator PrrA, is the DNA binding regulatory protein of a redox-responsive two-component regulatory system RegB/RegA that is involved in transactivating anaerobic expression of the photosynthetic apparatus. It contains a REC domain and a DNA-binding helix-turn-helix output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381111 [Multi-domain]  Cd Length: 112  Bit Score: 42.81  E-value: 1.40e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   2 NRILVLEDENMLNEMICDFLVANHFEVKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRKSGKNTPCIFTTs 81
Cdd:cd17563    1 KSLLLVDDDEVFAERLARALERRGFEVETAHSVEEALALAREEKPDYAVLDLRLGGDSGLDLIPPLRALQPDARIVVLT- 79

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 501056953  82 lndindlnkGFLS----------GCDDYLKKPFELAE 108
Cdd:cd17563   80 ---------GYASiataveaiklGADDYLAKPADADE 107
PRK10430 PRK10430
two-component system response regulator DcuR;
1-105 1.55e-05

two-component system response regulator DcuR;


Pssm-ID: 182454 [Multi-domain]  Cd Length: 239  Bit Score: 44.33  E-value: 1.55e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   1 MNRILVLEDENMLNEM-------ICDFlvaNHFEVKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRKSGKN 73
Cdd:PRK10430   1 MINVLIVDDDAMVAELnrryvaqIPGF---QCCGTASTLEQAKEIIFNSDTPIDLILLDIYMQQENGLDLLPVLHEAGCK 77

                         90       100       110
                 ....*....|....*....|....*....|..
gi 501056953  74 TPCIFTTSLNDINDLNKGFLSGCDDYLKKPFE 105
Cdd:PRK10430  78 SDVIVISSAADAATIKDSLHYGVVDYLIKPFQ 109
REC smart00448
cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar ...
 3-53 1.77e-05

cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar motors. This domain contains a phosphoacceptor site that is phosphorylated by histidine kinase homologues.


Pssm-ID: 214668 [Multi-domain]  Cd Length: 55  Bit Score: 41.01  E-value: 1.77e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 501056953     3 RILVLEDENMLNEMICDFLVANHFEVKSTKSYNEALDLAYEQNFDLWIFDV 53
Cdd:smart00448   2 RILVVDDDPLLRELLKALLEKEGYEVDEATDGEEALELLKEEKPDLILLDI 52
PRK10701 PRK10701
DNA-binding transcriptional regulator RstA; Provisional
 1-102 1.86e-05

DNA-binding transcriptional regulator RstA; Provisional


Pssm-ID: 236738 [Multi-domain]  Cd Length: 240  Bit Score: 44.24  E-value: 1.86e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   1 MNRILVLEDENMLNEMICDFLVANHFEVKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRKSGKNtPCIFTT 80
Cdd:PRK10701   1 MNKIVFVEDDAEVGSLIAAYLAKHDIDVTVEPRGDRAEATILREQPDLVLLDIMLPGKDGMTICRDLRPKWQG-PIVLLT 79

                         90       100
                 ....*....|....*....|....*
gi 501056953  81 SLNdiNDLNKgFLS---GCDDYLKK 102
Cdd:PRK10701  80 SLD--SDMNH-ILAlemGACDYILK 101
glnG PRK10923
nitrogen regulation protein NR(I); Provisional
 4-108 2.60e-05

nitrogen regulation protein NR(I); Provisional


Pssm-ID: 182842 [Multi-domain]  Cd Length: 469  Bit Score: 44.48  E-value: 2.60e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   4 ILVLEDENMLNEMICDFLVANHFEVKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRKSGKNTPCIFTTSLN 83
Cdd:PRK10923   6 VWVVDDDSSIRWVLERALAGAGLTCTTFENGNEVLEALASKTPDVLLSDIRMPGMDGLALLKQIKQRHPMLPVIIMTAHS 85

                         90       100
                 ....*....|....*....|....*
gi 501056953  84 DINDLNKGFLSGCDDYLKKPFELAE 108
Cdd:PRK10923  86 DLDAAVSAYQQGAFDYLPKPFDIDE 110
REC_NtrC cd19919
phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; ...
 25-108 4.25e-05

phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; DNA-binding transcriptional regulator NtrC is also called nitrogen regulation protein NR(I) or nitrogen regulator I (NRI). It contains an N-terminal receiver (REC) domain, followed by a sigma-54 interaction domain, and a C-terminal helix-turn-helix DNA-binding domain. It is part of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. DNA-binding response regulator NtrC is phosphorylated by NtrB; phosphorylation of the N-terminal REC domain activates the central sigma-54 interaction domain and leads to the transcriptional activation from promoters that require sigma(54)-containing RNA polymerase. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381146 [Multi-domain]  Cd Length: 116  Bit Score: 41.49  E-value: 4.25e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953  25 HFEVKSTKSYNEALD-LAYEQNfDLWIFDVKIIGGNGFKLLDELRKSGKNTPCIFTTSLNDINDLNKGFLSGCDDYLKKP 103
Cdd:cd19919   24 GLTVTSFENAQEALAaLASSQP-DVLISDIRMPGMDGLALLAQIKQRHPDLPVIIMTAHSDLDSAVSAYQGGAFEYLPKP 102


                 ....*
gi 501056953 104 FELAE 108
Cdd:cd19919  103 FDIDE 107
REC_DesR-like cd19930
phosphoacceptor receiver (REC) domain of DesR and similar proteins; This group is composed of ...
 4-108 4.60e-05

phosphoacceptor receiver (REC) domain of DesR and similar proteins; This group is composed of Bacillus subtilis DesR, Streptococcus pneumoniae response regulator spr1814, and similar proteins, all containing an N-terminal REC domain and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. DesR is a response regulator that, together with its cognate sensor kinase DesK, comprises a two-component regulatory system that controls membrane fluidity. Phosphorylation of the REC domain of DesR is allosterically coupled to two distinct exposed surfaces of the protein, controlling noncanonical dimerization/tetramerization, cooperative activation, and DesK binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381157 [Multi-domain]  Cd Length: 117  Bit Score: 41.49  E-value: 4.60e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   4 ILVLEDENMLNEMICDFL-VANHFE-VKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRKSGKNTPCIFTTS 81
Cdd:cd19930    1 VLIAEDQEMVRGALAALLeLEDDLEvVAQASNGQEALRLVLKHSPDVAILDIEMPGRTGLEVAAELREELPDTKVLIVTT 80

                         90       100       110
                 ....*....|....*....|....*....|
gi 501056953  82 LNDINDLNKGFLSGCDDYLKK---PFELAE 108
Cdd:cd19930   81 FGRPGYFRRALAAGVDGYVLKdrpIEELAD 110
REC_NtrX-like cd17550
phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and ...
 4-106 6.47e-05

phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and similar proteins; NtrX is part of the two-component regulatory system NtrY/NtrX that is involved in the activation of nitrogen assimilatory genes such as Gln. It is phosphorylated by the histidine kinase NtrY and interacts with sigma-54. NtrX is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. NtrC family response regulators are sigma54-dependent transcriptional activators. Also included in this subfamily is Aquifex aeolicus NtrC4. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381102 [Multi-domain]  Cd Length: 115  Bit Score: 40.94  E-value: 6.47e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   4 ILVLEDENMLNEMICDFLVANHFEVKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRKSGKNTPCIFTTSLN 83
Cdd:cd17550    1 ILIVDDEEDIRESLSGILEDEGYEVDTAADGEEALKLIKERRPDLVLLDIWLPDMDGLELLKEIKEKYPDLPVIMISGHG 80

                         90       100
                 ....*....|....*....|...
gi 501056953  84 DINDLNKGFLSGCDDYLKKPFEL 106
Cdd:cd17550   81 TIETAVKATKLGAYDFIEKPLSL 103
PRK10651 PRK10651
transcriptional regulator NarL; Provisional
 3-105 9.27e-05

transcriptional regulator NarL; Provisional


Pssm-ID: 182619 [Multi-domain]  Cd Length: 216  Bit Score: 41.94  E-value: 9.27e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   3 RILVLEDENMLN-------EMICDFLVanhfeVKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRKSGKNTP 75
Cdd:PRK10651   8 TILLIDDHPMLRtgvkqliSMAPDITV-----VGEASNGEQGIELAESLDPDLILLDLNMPGMNGLETLDKLREKSLSGR 82

                         90       100       110
                 ....*....|....*....|....*....|
gi 501056953  76 CIFTTSLNDINDLNKGFLSGCDDYLKKPFE 105
Cdd:PRK10651  83 IVVFSVSNHEEDVVTALKRGADGYLLKDME 112
REC_CheY cd17542
phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response ...
 2-105 1.60e-04

phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response regulator CheY contains a stand-alone REC domain. Chemotaxis is a behavior known for motile bacteria that directs their movement in response to chemical gradients. CheY is involved in transmitting sensory signals from chemoreceptors to the flagellar motors. Phosphorylated CheY interacts with the flagella switch components FliM and FliY, which causes counterclockwise rotation of the flagella, resulting in smooth swimming. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381097 [Multi-domain]  Cd Length: 117  Bit Score: 39.95  E-value: 1.60e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   2 NRILVLEDENMLNEMICDFLVANHFEVKSTKSY-NEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRKSGKNTPCIFTT 80
Cdd:cd17542    1 KKVLIVDDAAFMRMMLKDILTKAGYEVVGEAANgEEAVEKYKELKPDLVTMDITMPEMDGIEALKEIKKIDPNAKVIMCS 80

                         90       100
                 ....*....|....*....|....*
gi 501056953  81 SLNDINDLNKGFLSGCDDYLKKPFE 105
Cdd:cd17542   81 AMGQEEMVKEAIKAGAKDFIVKPFQ 105
dpiA PRK10046
two-component response regulator DpiA; Provisional
 4-103 1.95e-04

two-component response regulator DpiA; Provisional


Pssm-ID: 182208 [Multi-domain]  Cd Length: 225  Bit Score: 41.16  E-value: 1.95e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   4 ILVLEDENMLNEMICDFlvanhfeVKSTKSYNE---ALDLAYEQNF------DLWIFDVKIIGGNGFKLLDELRKSGKNT 74
Cdd:PRK10046   7 LLIVEDETPLAEMHAEY-------IRHIPGFSQillAGNLAQARMMierfkpGLILLDNYLPDGRGINLLHELVQAHYPG 79

                         90       100
                 ....*....|....*....|....*....
gi 501056953  75 PCIFTTSLNDINDLNKGFLSGCDDYLKKP 103
Cdd:PRK10046  80 DVVFTTAASDMETVSEAVRCGVFDYLIKP 108
PRK15115 PRK15115
response regulator GlrR; Provisional
 3-103 2.43e-04

response regulator GlrR; Provisional


Pssm-ID: 185070 [Multi-domain]  Cd Length: 444  Bit Score: 41.36  E-value: 2.43e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   3 RILVLEDENMLNEMICDFLVANHFEVKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRKSGKNTPCIFTTSL 82
Cdd:PRK15115   7 HLLLVDDDPGLLKLLGMRLTSEGYSVVTAESGQEALRVLNREKVDLVISDLRMDEMDGMQLFAEIQKVQPGMPVIILTAH 86

                         90       100
                 ....*....|....*....|.
gi 501056953  83 NDINDLNKGFLSGCDDYLKKP 103
Cdd:PRK15115  87 GSIPDAVAATQQGVFSFLTKP 107
REC_RcNtrC-like cd19928
phosphoacceptor receiver (REC) domain of Rhodobacter capsulatus nitrogen regulatory protein C ...
 4-103 3.41e-04

phosphoacceptor receiver (REC) domain of Rhodobacter capsulatus nitrogen regulatory protein C (NtrC) and similar NtrC family response regulators; NtrC family proteins are transcriptional regulators that have REC, AAA+ ATPase/sigma-54 interaction, and DNA-binding output domains. This subfamily of NtrC proteins include NtrC, also called nitrogen regulator I (NRI), from Rhodobacter capsulatus, Azospirillum brasilense, and Azorhizobium caulinodans. NtrC is part of the NtrB/NtrC two-component system that controls the expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. The N-terminal REC domain of NtrC proteins regulate the activity of the protein and its phosphorylation controls the AAA+ domain oligomerization, while the central AAA+ domain participates in nucleotide binding, hydrolysis, oligomerization, and sigma54 interaction. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381155 [Multi-domain]  Cd Length: 100  Bit Score: 38.64  E-value: 3.41e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   4 ILVLEDENMLNEMICDFLVANHFEVKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRKSGKNTPCIFTTSLN 83
Cdd:cd19928    1 ILVADDDRAIRTVLTQALGRAGYEVRTTGNAATLWRWVEEGEGDLVITDVVMPDENGLDLIPRIKKARPDLPIIVMSAQN 80

                         90       100
                 ....*....|....*....|
gi 501056953  84 DINDLNKGFLSGCDDYLKKP 103
Cdd:cd19928   81 TLMTAVKAAERGAFEYLPKP 100
REC_hyHK_blue-like cd18161
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinase/response regulators ...
 4-104 4.06e-04

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinase/response regulators similar to Pseudomonas savastanoi blue-light-activated histidine kinase; Typically, two-component regulatory systems (TCSs) consist of a sensor (histidine kinase) that responds to specific input(s) by modifying the output of a cognate response regulator (RR). TCSs allow organisms to sense and respond to changes in environmental conditions. Hybrid sensor histidine kinase (HK)/response regulators contain all the elements of a classical TCS in a single polypeptide chain. Pseudomonas savastanoi blue-light-activated histidine kinase is a photosensitive HK and RR that is involved in increased bacterial virulence upon exposure to light. RRs share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381145 [Multi-domain]  Cd Length: 102  Bit Score: 38.48  E-value: 4.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   4 ILVLEDENMLNEMICDFLVANHFEVKSTKSYNEALD-LAYEQNFDLWIFDVKIIGG-NGFKLLDELRKSGKNTPCIFTT- 80
Cdd:cd18161    1 VLVVEDDPDVRRLTAEVLEDLGYTVLEAASGDEALDlLESGPDIDLLVTDVIMPGGmNGSQLAEEARRRRPDLKVLLTSg 80

                         90       100
                 ....*....|....*....|....*..
gi 501056953  81 -SLNDI--NDLNKGFlsgcdDYLKKPF 104
Cdd:cd18161   81 yAENAIegGDLAPGV-----DVLSKPF 102
PRK10365 PRK10365
sigma-54-dependent response regulator transcription factor ZraR;
4-106 4.21e-04

sigma-54-dependent response regulator transcription factor ZraR;


Pssm-ID: 182412 [Multi-domain]  Cd Length: 441  Bit Score: 40.78  E-value: 4.21e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   4 ILVLEDENMLNEMICDFLVANHFEVKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRKSGKNTPCIFTTSLN 83
Cdd:PRK10365   8 ILVVDDDISHCTILQALLRGWGYNVALANSGRQALEQVREQVFDLVLCDVRMAEMDGIATLKEIKALNPAIPVLIMTAYS 87

                         90       100
                 ....*....|....*....|...
gi 501056953  84 DINDLNKGFLSGCDDYLKKPFEL 106
Cdd:PRK10365  88 SVETAVEALKTGALDYLIKPLDF 110
REC_PdtaR-like cd19932
phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes ...
 3-104 5.33e-04

phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes Mycobacterium tuberculosis PdtaR, also called Rv1626, and similar proteins containing a REC domain and an ANTAR (AmiR and NasR transcription antitermination regulators) RNA-binding output domain. PdtaR is a response regulator that acts at the level of transcriptional antitermination and is a member of the PdtaR/PdtaS two-component regulatory system. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381159 [Multi-domain]  Cd Length: 118  Bit Score: 38.55  E-value: 5.33e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   3 RILVLEDENMLNEMICDFLVANHFEVKSTKSYN-EALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRKSgKNTPCIFTTS 81
Cdd:cd19932    2 RVLIAEDEALIRMDLREMLEEAGYEVVGEASDGeEAVELAKKHKPDLVIMDVKMPRLDGIEAAKIITSE-NIAPIVLLTA 80

                         90       100
                 ....*....|....*....|...
gi 501056953  82 LNDINDLNKGFLSGCDDYLKKPF 104
Cdd:cd19932   81 YSQQDLVERAKEAGAMAYLVKPF 103
REC_FixJ cd17537
phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response ...
 50-105 6.01e-04

phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response regulators contain an N-terminal receiver domain (REC) and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. The Sinorhizobium meliloti two-component system FixL/FixJ regulates nitrogen fixation in response to oxygen during symbiosis. Under microaerobic conditions, the kinase FixL phosphorylates the response regulator FixJ resulting in the regulation of nitrogen fixation genes such as nifA and fixK. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381092 [Multi-domain]  Cd Length: 116  Bit Score: 38.34  E-value: 6.01e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 501056953  50 IFDVKIIGGNGFKLLDELRKSGKNTPCIFTTSLNDINDLNKGFLSGCDDYLKKPFE 105
Cdd:cd17537   49 VLDVRMPGMSGLELQDELLARGSNIPIIFITGHGDVPMAVEAMKAGAVDFLEKPFR 104
REC_YesN-like cd17536
phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response ...
 36-108 6.47e-04

phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response regulators; This family is composed of uncharacterized response regulators that contain a REC domain and a AraC family helix-turn-helix (HTH) DNA-binding output domain, including Bacillus subtilis uncharacterized transcriptional regulatory protein YesN and Staphylococcus aureus uncharacterized response regulatory protein SAR0214. YesN is a member of the two-component regulatory system YesM/YesN and SAR0214 is a member of the probable two-component regulatory system SAR0215/SAR0214. Also included in this family is the AlgR-like group of LytTR/AlgR family response, which includes Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR and Bacillus subtilis sensory transduction protein LytT, among others. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381091 [Multi-domain]  Cd Length: 121  Bit Score: 38.09  E-value: 6.47e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 501056953  36 EALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRKSGKNTPCIFTTSLNDINDLNKGFLSGCDDYLKKPFELAE 108
Cdd:cd17536   36 EALELIEEHKPDIVITDIRMPGMDGLELIEKIRELYPDIKIIILSGYDDFEYAQKAIRLGVVDYLLKPVDEEE 108
REC_NarL cd19931
phosphoacceptor receiver (REC) domain of Nitrate/Nitrite response regulator L (NarL); Nitrate ...
 4-105 1.31e-03

phosphoacceptor receiver (REC) domain of Nitrate/Nitrite response regulator L (NarL); Nitrate/nitrite response regulator protein NarL contains an N-terminal REC domain and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. Escherichia coli NarL activates the expression of the nitrate reductase (narGHJI) and formate dehydrogenase-N (fdnGHI) operons, and represses the transcription of the fumarate reductase (frdABCD) operon in response to a nitrate/nitrite induction signal. Phosphorylation of the NarL REC domain releases the C-terminal HTH output domain that subsequently binds specific DNA promoter sites to repress or activate gene expression. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381158 [Multi-domain]  Cd Length: 117  Bit Score: 37.33  E-value: 1.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   4 ILVLEDENMLNEMICDFL-VANHFEV-KSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRKSGKNTPCIFTTS 81
Cdd:cd19931    1 VLLIDDHPLLRKGIKQLIeLDPDFTVvGEASSGEEGIELAERLDPDLILLDLNMKGMSGLDTLKALREEGVSARIVILTV 80

                         90       100
                 ....*....|....*....|....
gi 501056953  82 LNDINDLNKGFLSGCDDYLKKPFE 105
Cdd:cd19931   81 SDAEDDVVTALRAGADGYLLKDME 104
AmiR COG3707
Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding ...
 1-104 1.88e-03

Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding antiterminator (ANTAR) domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 442921 [Multi-domain]  Cd Length: 194  Bit Score: 38.01  E-value: 1.88e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   1 MNRILVLEDENMLNEMICDFLVANHFEV-KSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRKSgKNTPCIFT 79
Cdd:COG3707    3 GLRVLVVDDEPLRRADLREGLREAGYEVvAEAADGEDAVELVRELKPDLVIVDIDMPDRDGLEAARQISEE-RPAPVILL 81

                         90       100
                 ....*....|....*....|....*
gi 501056953  80 TSLNDINDLNKGFLSGCDDYLKKPF 104
Cdd:COG3707   82 TAYSDPELIERALEAGVSAYLVKPL 106
fixJ PRK09390
response regulator FixJ; Provisional
 19-105 2.23e-03

response regulator FixJ; Provisional


Pssm-ID: 181815 [Multi-domain]  Cd Length: 202  Bit Score: 37.67  E-value: 2.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953  19 DFLVA-NHFEVKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRKSGKNTPCIFTTSLNDINDLNKGFLSGCD 97
Cdd:PRK09390  20 AFLLDsAGFEVRLFESAQAFLDALPGLRFGCVVTDVRMPGIDGIELLRRLKARGSPLPVIVMTGHGDVPLAVEAMKLGAV 99


                 ....*...
gi 501056953  98 DYLKKPFE 105
Cdd:PRK09390 100 DFIEKPFE 107
REC_NtrC1-like cd17572
phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex ...
 4-108 3.24e-03

phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex aeolicus and similar NtrC family response regulators; NtrC family proteins are transcriptional regulators that have REC, AAA+ ATPase/sigma-54 interaction, and DNA-binding output domains. This subfamily of NtrC proteins include Aquifex aeolicus NtrC1 and Vibrio quorum-sensing signal integrator LuxO. The N-terminal REC domain of NtrC proteins regulate the activity of the protein and its phosphorylation controls the AAA+ domain oligomerization, while the central AAA+ domain participates in nucleotide binding, hydrolysis, oligomerization, and sigma54 interaction. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381114 [Multi-domain]  Cd Length: 121  Bit Score: 36.41  E-value: 3.24e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   4 ILVLEDENMLNEMICDFLVANHFEVKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRKSGKNTPCIFTTSLN 83
Cdd:cd17572    1 VLLVEDSPSLAALYQEYLSDEGYKVTHVETGKEALAFLSDQPPDVVLLDLKLPDMSGMEILKWIQERSLPTSVIVITAHG 80

                         90       100
                 ....*....|....*....|....*...
gi 501056953  84 DIN---DLNKGflsGCDDYLKKPFELAE 108
Cdd:cd17572   81 SVDiavEAMRL---GAYDFLEKPFDADR 105
REC_PatA-like cd17602
phosphoacceptor receiver (REC) domain of PatA and similar domains; Nostoc sp. (or Anabaena sp.) ...
 4-103 3.44e-03

phosphoacceptor receiver (REC) domain of PatA and similar domains; Nostoc sp. (or Anabaena sp.) PatA is necessary for proper patterning of heterocysts along filaments. PatA contains phosphoacceptor REC domain at its C-terminus and an N-terminal PATAN (PatA N-terminus) domain, which was proposed in a bioinformatics study to mediate protein-protein interactions. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays. Some members of this group may have an inactive REC domain, lacking canonical metal-binding and active site residues.


Pssm-ID: 381129 [Multi-domain]  Cd Length: 102  Bit Score: 35.81  E-value: 3.44e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   4 ILVLEDENMLNEMICDFLVANHFEVKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRKSG--KNTPCIFTTS 81
Cdd:cd17602    1 VACVDDRPSIQKMIEYFLEKQGFRVVVIDDPLRALTTLLNSKPDLILIDIDMPDLDGYELCSLLRKSSalKDTPIIMLTG 80

                         90       100
                 ....*....|....*....|..
gi 501056953  82 LNDINDLNKGFLSGCDDYLKKP 103
Cdd:cd17602   81 KDGLVDRIRAKMAGASGYLTKP 102
PRK10816 PRK10816
two-component system response regulator PhoP;
3-218 4.48e-03

two-component system response regulator PhoP;


Pssm-ID: 182755 [Multi-domain]  Cd Length: 223  Bit Score: 37.03  E-value: 4.48e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   3 RILVLEDENMLNEMICDFLVANHFEVKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRKSGKNTPCIFTTSL 82
Cdd:PRK10816   2 RVLVVEDNALLRHHLKVQLQDAGHQVDAAEDAKEADYYLNEHLPDIAIVDLGLPDEDGLSLIRRWRSNDVSLPILVLTAR 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953  83 NDINDLNKGFLSGCDDYLKKPFELAElllriNNLLRRNFAHKNShieklcdGLA----------FDIYEKRLFKNGEPVN 152
Cdd:PRK10816  82 ESWQDKVEVLSAGADDYVTKPFHIEE-----VMARMQALMRRNS-------GLAsqvislppfqVDLSRRELSINDEVIK 149

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 501056953 153 LSKKEMTLLTLLLQKKNKSVSREEIYSAVWDIDEMPSELSLRVYIRNLR-KIFGKH----IVSISKVGYSY 218
Cdd:PRK10816 150 LTAFEYTIMETLIRNNGKVVSKDSLMLQLYPDAELRESHTIDVLMGRLRkKIQAQYpqevITTVRGQGYRF 220
REC_PilR cd19926
phosphoacceptor receiver (REC) domain of type 4 fimbriae expression regulatory protein PilR ...
 4-103 6.28e-03

phosphoacceptor receiver (REC) domain of type 4 fimbriae expression regulatory protein PilR and similar proteins; Pseudomonas aeruginosa PilR is the response regulator of the PilS/PilR two-component regulatory system (PilSR TCS) that acts in conjunction with sigma-54 to regulate the expression of type 4 pilus (T4P) major subunit PilA. In addition, the PilSR TCS regulates flagellum-dependent swimming motility and pilus-dependent twitching motility. PilR contains an N-terminal REC domain, a central sigma-54 interaction domain, and a C-terminal Fis-type helix-turn-helix DNA-binding domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381153 [Multi-domain]  Cd Length: 100  Bit Score: 35.21  E-value: 6.28e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   4 ILVLEDENMLNEMICDFLVANHFEVKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRKSGKNTPCIFTTSLN 83
Cdd:cd19926    1 VLVVDDEPDIRELLEITLGRMGLDVRSARNVKEARELLASEPYDLCLTDMRLPDGSGLELVQHIQQRLPQTPVAVITAYG 80

                         90       100
                 ....*....|....*....|
gi 501056953  84 DINDLNKGFLSGCDDYLKKP 103
Cdd:cd19926   81 SLDTAIEALKAGAFDFLTKP 100
REC_Spo0F-like cd17553
phosphoacceptor receiver (REC) domain of Spo0F and similar domains; Spo0F, a stand-alone ...
 3-108 8.51e-03

phosphoacceptor receiver (REC) domain of Spo0F and similar domains; Spo0F, a stand-alone response regulator containing only a REC domain with no output/effector domain, controls sporulation in Bacillus subtilis through the exchange of a phosphoryl group. Bacillus subtilis forms spores when conditions for growth become unfavorable. The initiation of sporulation is controlled by a phosphorelay (an expanded version of the two-component system) that consists of four main components: a histidine kinase (KinA), a secondary messenger (Spo0F), a phosphotransferase (Spo0B), and a transcription factor (Spo0A). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381105 [Multi-domain]  Cd Length: 117  Bit Score: 35.22  E-value: 8.51e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501056953   3 RILVLEDENMLNEMICDFLVANHFEVKSTKSYNEALDLAYEQNFDLWIFDVKIIGGNGFKLLDELRKSGKNTPCIFTTSL 82
Cdd:cd17553    2 KILIVDDQYGIRILLNEVFNKEGYQTFQAANGLQALDIVTKERPDLVLLDMKIPGMDGIEILKRMKVIDENIRVIIMTAY 81

                         90       100
                 ....*....|....*....|....*.
gi 501056953  83 NDINDLNKGFLSGCDDYLKKPFELAE 108
Cdd:cd17553   82 GELDMIQESKELGALTHFAKPFDIDE 107
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH