|
Name |
Accession |
Description |
Interval |
E-value |
| 2A0118 |
TIGR00897 |
polyol permease family; This family of proteins includes the ribitol and D-arabinitol ... |
1-406 |
0e+00 |
|
polyol permease family; This family of proteins includes the ribitol and D-arabinitol transporters from Klebsiella pneumoniae and the alpha-ketoglutarate permease from Bacillus subtilis. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 162096 Cd Length: 402 Bit Score: 522.47 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 1 MSLTNKQWLGLPLSLVWGYIAIAVFMTGDGFELAFLSHYIKALGFTPAEASFAFTLYGLAAALSAWVSGVVAEIITPQKT 80
Cdd:TIGR00897 1 MSINNLQKIGIPLNLLWGYIGVVVFMTGDGLEQGWLSPFLKALGLSPQQSASAFTLYGIAAAISAWISGVVAEIIGPLKT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 81 MMIGFVLWCVFHVLFLVFGLGQSNYALILLFYGIRGLAYPLFLYAFIVAIVHNVRSDSTSAALGWFWAVYSIGIGVFGSY 160
Cdd:TIGR00897 81 MMIGLLLWCVGHAAFIVFGLGHANYPLILLFYGIRGLGYPLFAYSFLVWVVYNTKQDNLSSAVGWFWAVYSIGIGVFGSY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 161 IPSFTIPHIGEMGTLWLALAFCLTGGVIALVSLRKIETPRHMQnltTREKFSELGRAVTLLYTNRSIMLSSIVRIINTLS 240
Cdd:TIGR00897 161 YSSYAIPAFGEMNTLWSALAFVLTGGVIALFSNKDIFTPQHMQ---TREKFSELGKAATILFTNPNVLLGGMVRIINTIG 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 241 LFGFAVVMPmMFVDELGFTTSEWLQVWAAFFFTTIFSNVFWGVLAEKMGWMKVVRWFGCIGMALSSLAFYYIPQHFGHNF 320
Cdd:TIGR00897 238 LFGFAVFLP-MFVAELGFSTSEWLQIWGTFFFTNIVFNVIFGIVGDKLGWMNTVRWFGGVGCGIFTLALYYIPQHFGHSF 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 321 AMALVPAIALGIFVAAFVPMAAVFPALEPKHKGAAISVYNLSAGLSNFLAPAIAVVLLPHFSTIGVVIAYTLLYIVAFIL 400
Cdd:TIGR00897 317 AVALIIAIALGIFLAGYVPLAAVFPTLAPKHKGAAMSVLNLSAGLSAFLAPAIAVLFIGFFGAIGVVWIFAALYVVSAFL 396
|
....*.
gi 501081055 401 CPFIRV 406
Cdd:TIGR00897 397 TAFIRI 402
|
|
| MFS_CsbX |
cd17337 |
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed ... |
17-405 |
1.85e-176 |
|
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed of Bacillus subtilis CsbX protein (also named alpha-ketoglutarate permease), Klebsiella pneumoniae D-arabinitol transporter (DalT), and similar proteins. The csbX gene is a sigmaB-controlled gene that is expressed during the stationary phase of cell growth. DalT is a pentose-specific ion symporter for D-arabinitol uptake. Most members of this family remain uncharacterized. The CsbX family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340895 [Multi-domain] Cd Length: 388 Bit Score: 497.79 E-value: 1.85e-176
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 17 WGYIAIAVFMTGDGFELAFLSHYIKALGFTPAEASFAFTLYGLAAALSAWVSGVVAEIITPQKTMMIGFVLWCVFHVLFL 96
Cdd:cd17337 1 WGYIGVLLFMIGDGVEQGFLSPYLVDLGFSEAQAALLFTVYGLTVAIASWLSGVLAELFGPRRVMLIGLIIWLVFEVLFL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 97 VFGLGQSNYALILLFYGIRGLAYPLFLYAFIVAIVHNVRSDSTSAALGWFWAVYSIGIGVFGSYIPSFTIPHIGEMGTLW 176
Cdd:cd17337 81 AFGLPSHNYPLMLLTYGLRGFGYPLFAYSFLVWITYRTPAERLGSAVGWFWFAFTGGLPVLGSYLASFTIPVIGEIGTLW 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 177 LALAFCLTGGVIALVSLRKIETPRHMQNlTTREKFSELGRAVTLLYTNRSIMLSSIVRIINTLSLFGFAVVMPMMFVDEL 256
Cdd:cd17337 161 LSLVFVALGGLIALFLVRDRTGEQPLAN-PSEEPLKELLSGITILFRNPKIAIGGIVRIINTLSQFGFPVFMPLYFTDTG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 257 GFTTSEWLQVWAAFFFTTIFSNVFWGVLAEKMGWMKVVRWFGCIGMALSSLAFYYIPQHFGHNFAMALVPAIALGIFVAA 336
Cdd:cd17337 240 GFSTSQWLQIWGIIFLVNIFFNLIFGILGDKIGWRRTVRWFGGVGCAISTLLFYYVPQLFGHNYWAALIAAILFGIGLAG 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 501081055 337 FVPMAAVFPALEPKHKGAAISVYNLSAGLSNFLAPAIAVVLLPHFSTIGVVIAYTLLYIVAFILCPFIR 405
Cdd:cd17337 320 FVPLSALMPSLAPEHKGAAMSILNLGAGLSNFVGPAIVTLFLGSFGAGGVVWIFAGLYLLSAVLTLFLK 388
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
19-405 |
1.83e-19 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 89.17 E-value: 1.83e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 19 YIAIAVFMTGDGFELAFLSHYIKALGFTPAEASFAFTLYGLAAALSAWVSGVVAEIITPQKTMMIGFVLWCVFHVLFLVF 98
Cdd:cd17325 2 SLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 99 glgqSNYALILLFYGIRGLAYPLFLYAFIVAIVHNVRSDSTSAALGWFWAVYSIGIgVFGSYIPSFTIPHIGEMGTLWLA 178
Cdd:cd17325 82 ----TSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGF-LIGPLLGGLLADALGYRAPFLVC 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 179 LAFCLTGGVIALVSLRKIETPRHmqnlTTREKFSELGRAVTLLYTNRSIMLSSIVRIINTLSLFGFAVVMPMMFVDELGF 258
Cdd:cd17325 157 AALALLALVLALLLLPEPRPPPN----KRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 259 TTSEWLQVWAAFFFTTIFSNVFWGVLAEKMGwmkvVRWFGCIGMALSSLAFYYIPqhFGHNFAMALVPAIALGIFVAAFV 338
Cdd:cd17325 233 SPAQIGLLFGAQGLASALSQPPAGKLSDRIG----RKPLILIGLLLSAVALLLLP--LATSFWLLLLLLALLGLGLGLVF 306
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 501081055 339 P--MAAVFPALEPKHKGAAISVYNLSAGLSNFLAPAIAVVLLPHFSTIGVVIAYTLLYIVAFILCPFIR 405
Cdd:cd17325 307 PatLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
20-370 |
2.48e-16 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 79.63 E-value: 2.48e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 20 IAIAVFMTGDGFELAFLSHYIKALGFTPAEASFAFTLYGLAAALSAWVSGVVAEIITPQKTMMIGFVLWCVFHVLFLVFg 99
Cdd:COG2814 17 LGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALA- 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 100 lgqSNYALILLFYGIRGLAYPLFLYAFIVAIVHNVRSDSTSAALGWFWAVYSIGIgVFGSYIPSFTIPHIGEMGTLWLAL 179
Cdd:COG2814 96 ---PSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGP-ALGPLLGGLLADLFGWRWVFLVNA 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 180 AFCLTGGVIALVSLRKietprhmqnlTTREKFSELGRAVTLLYTNRSIMLSSIVRIINTLSLFGFAVVMPMMFVDELGFT 259
Cdd:COG2814 172 VLALLALLLLLRLLPE----------SRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLS 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 260 TSEWLQVWAAFFFTTIFSNVFWGVLAEKMGWMKVVrWFGCIGMALSSLAFyyipqHFGHNFAMALVPAIALGIFVAAFVP 339
Cdd:COG2814 242 ASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLL-LIGLLLLALGLLLL-----ALAGSLWLLLLALFLLGFGFGLLFP 315
|
330 340 350
....*....|....*....|....*....|...
gi 501081055 340 --MAAVFPALEPKHKGAAISVYNLSAGLSNFLA 370
Cdd:COG2814 316 llQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
34-401 |
4.27e-16 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 79.39 E-value: 4.27e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 34 AFLSHYIKALGFTPAEASFAFTLYGLAAALSAWVSGVVAEIITPQKTMMIGFVLWCVFHVLFLVFglgqSNYALILLFYG 113
Cdd:cd06174 17 PLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFA----PSFWLLLLGRF 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 114 IRGLAYPLFLYAFIVAIVHNVRSDSTSAALGWFWAVYSIGiGVFGSYIPSFTIPHIGEMGTLWLALAFCLTGGVIALVSL 193
Cdd:cd06174 93 LLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVG-GILGPLLGGILASSLGFGWRAVFLIAAALALLAAILLLL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 194 RKIETPRHMQNLTTREKFSELGRAVTLLYTNRSIMLSSIVRIINTLSLFGFAVVMPMMFVDELGFTTSEWLQVWAAFFFT 273
Cdd:cd06174 172 VVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLA 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 274 TIFSNVFWGVLAEKMGWMKVVRWFGCIGMALSSLAFYYIPQHFGHNFAMALvpaIALGIFVAAFVPMAAVFPALEPKHKG 353
Cdd:cd06174 252 GALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLL---LGFGLGGLLPLSFALIAELFPPEIRG 328
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 501081055 354 AAISVYNLSAGLSNFLAPAIAVVLLPHFSTIGVV-IAYTLLYIVAFILC 401
Cdd:cd06174 329 TAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAfLVLAVLLLLAAILL 377
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
41-406 |
6.13e-14 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 72.99 E-value: 6.13e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 41 KALGFTPAEASFAFTLYGLAAALSAWVSGVVAEIITPQKTMMIGFVLWCVFHVLFLVFglgqSNYALILLFYGIRGLAYP 120
Cdd:COG2223 33 EEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALA----VSYWLLLLLGLLLGIGGG 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 121 LFLYAFIVAIVHNVRSDSTSAALGWFWAVYSIGIGVFGSYIPSFtIPHIGEMGTLWLALAFCLtggVIALVSLRKIETPR 200
Cdd:COG2223 109 GSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLL-IAAFGWRNAFLILGILLL---VVAVLAWLFLRDPP 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 201 HMQNLTTREKFSELGRAVTllytNRSIMLSSIVRIINTLSLFGFAVVMPMMFVDELGFTTSEWLQVWAAFFFTTIFSNVF 280
Cdd:COG2223 185 AGAAAAAKASLRDQLEALR----DPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPL 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 281 WGVLAEKMGWMKVVRWFGcIGMALSSLAFYYIPQHFGHNFAMALVPAIALGIFVAAFVPMAAVFpaLEPKHKGAAISVYN 360
Cdd:COG2223 261 GGWLSDRIGGRRVLLIVF-ALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDI--FPTKNAGAVYGLVG 337
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 501081055 361 LSAGLSNFLAPAIAVVLLPHFSTIGVV-IAYTLLYIVAFILCPFIRV 406
Cdd:COG2223 338 AAGGLGGFLGPLLFGALLDATGSYTAAfLVFAVLALVALVLTLLLYR 384
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
34-407 |
2.52e-12 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 67.59 E-value: 2.52e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 34 AFLSHYIKALGFTPAEASFAFTLYGLAAALSAWVSGVVAEIITPQKTMMIGFVLWCVFHVLFLVFglgqSNYALILLFYG 113
Cdd:COG2271 31 VAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFA----TSFWQLLLLRF 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 114 IRGLAYPLFLYAFIVAIVHNVRSDSTSAALGWFWAVYSIGiGVFGSYIPSFTIPHIGEMGTLWLALAFCLTGGVIAlvsl 193
Cdd:COG2271 107 LLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLG-GALAPPLLGWLLAAFGWRAAFLILGLPGLLLALLR---- 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 194 rkietprhmqnlttrekfselgravtllytnrsIMLSSIVRIINTLSLFGFAVVMPMMFVDELGFTTSEWLQVWAAFFFT 273
Cdd:COG2271 182 ---------------------------------FWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLA 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 274 TIFSNVFWGVLAEKMGwmKVVRWFGCIGMALSSLAFYYIPqhFGHNFAMALVPAIALGIFVAAFVPMAAVFPA--LEPKH 351
Cdd:COG2271 229 GIVGSLLGGWLSDRLG--RRRKLVLAIGLLLAALALLLLA--LLPSPALAIALLFLAGFGLGGAFGLLWALAAelFPKKA 304
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 501081055 352 KGAAISVYNLSAGLSNFLAPAIAVVLLPHFSTIGVVIAYTLLYIVAFILCPFIRVE 407
Cdd:COG2271 305 RGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRE 360
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
20-371 |
8.80e-12 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 65.90 E-value: 8.80e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 20 IAIAVFMTGDGFELAFLSHYIKALGFTPAEASFAFTLYGLAAALSAWVSGVVAEIITPQKTMMIGFVLWCVFHVLFLVFg 99
Cdd:pfam07690 4 AAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFA- 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 100 lgqSNYALILLFYGIRGLAYPLFLYAFIVAIVHNVRSDSTSAALGWFWAVYSIGIgVFGSYIPSFTIPHIGEMGTLWLAL 179
Cdd:pfam07690 83 ---SSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGA-ALGPLLGGLLASLFGWRAAFLILA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 180 AFCLTGGVIALVslrkIETPRHMQNLTTREKFSELGRAVTLLYTNRSIMLSSIVRIINTLSLFGFAVVMPmMFVDELGFT 259
Cdd:pfam07690 159 ILSLLAAVLLLL----PRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLP-LYQEVLGLS 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 260 TSEWLQVWAAFFFTTIFSNVFWGVLAEKMGWmKVVRWFGCIGMALSSLAFYYIPqhFGHNFAMALVPAIALGIFVAAFVP 339
Cdd:pfam07690 234 ALLAGLLLGLGGLLGAIGRLLLGRLSDRLGR-RRRLLLALLLLILAALGLLLLS--LTLSSLWLLLALLLLGFGFGLVFP 310
|
330 340 350
....*....|....*....|....*....|....
gi 501081055 340 MAAVFPA--LEPKHKGAAISVYNLSAGLSNFLAP 371
Cdd:pfam07690 311 ALNALVSdlAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
36-405 |
6.09e-10 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 60.64 E-value: 6.09e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 36 LSHYIKALGFTPAEASFAFTLYGLAAALSAWVSGVVAEIITPQKTMMIGFVLWCVFHVLFLVFGlgqsNYALILLFYGIR 115
Cdd:COG0738 31 IPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAP----SYPLLLLALFLL 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 116 GLAYPLFLYAfIVAIVHNVRSDSTSAALGWFWAVYSIGI---GVFGSYIPSFTIPHIGEMGTLWLALAFCLTGGVIALVS 192
Cdd:COG0738 107 GLGLGLLDVA-ANPYVAALGPETAASRLNLLHAFFSLGAllgPLLGGLLILLGLSLSWHLPYLILAVLLLLLALLFLRSK 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 193 LRKIETPRHMQNLTTREKFSelgravtlLYTNRSIMLSSIVRIINTLSLFGFAVVMPMMFVDELGFTTSEWLQVWAAFFF 272
Cdd:COG0738 186 LPEIEEEEEEAAGSAASLKS--------LLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWG 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 273 TTIFSNVFWGVLAEKMGWMKVVRWFGCIGMALSSLAFyyipqhFGHNFAMALVPAIALGIFVAAFVPMA-AVFPALEPKH 351
Cdd:COG0738 258 GMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLAL------LAPGPWLALIGLALVGLGLSLMFPTIfSLALDGLGKR 331
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 501081055 352 KGAAISVYNLSAGLSNFLAPAIAVVLLPHFSTIGVVIAYTLLYIVAFILCPFIR 405
Cdd:COG0738 332 TAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALK 385
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
20-404 |
3.37e-09 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 58.40 E-value: 3.37e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 20 IAIAVFMTGDGFELAFLSHYIKALGFTPAEASFAFTLYGLAAALSAWVSGVVAEIITPQKTMMIGFVLWCV-FHVLFLVF 98
Cdd:cd06173 6 LAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALlAAVLALLA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 99 GLGQSNYALILLFYGIRGLAYPLFLYAFIVAIVHNVRSDSTSAALGWFWAVYSIGIgVFGSYIPSFTIPHIGEMGTLWLA 178
Cdd:cd06173 86 LLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLAR-IIGPALGGLLVALLGPGGAFAIN 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 179 lAFCLTGGVIALVSLRKieTPRHMQNLTTREKFSELGRAVTLLYTNRSIMLSSIVRIINTLSLFGFAVVMPMMFVDELGF 258
Cdd:cd06173 165 -ALSFLLSALLLLFIRR--PPPAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGG 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 259 TTSEWLQVWAAFFFTTIFSNVFWGVLAEKMGWMKVVRWfGCIGMALSSLAFYyipqhFGHNFAMALVPAIALGIFVAAF- 337
Cdd:cd06173 242 GAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLI-GALLLGLALLVLG-----LSPSLWLLLAALFLLGLAGGLFn 315
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 501081055 338 VPMAAVFPALEPKHK-GAAISVYNLSAGLSNFLAPAIAVVLLPHFSTIGVVIAYTLLYIVAFILCPFI 404
Cdd:cd06173 316 VPLNTLLQLRVPDELrGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
41-401 |
6.96e-09 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 57.17 E-value: 6.96e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 41 KALGFTPAEASFAFTLYGLAAALSAWVSGVVAEIITPQKTMMIGFVLWCVFHVLFLVfglgQSNYALILLFYGIRGLAYP 120
Cdd:cd17324 27 RDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAAL----APSFALLLLARALAGLAHG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 121 LFLYAFIVAIVHNVRSDSTSAALGWFWAVYSIGIgVFGSYIPSFTIPHIGEMGTLWLALAFCLTGGVIALVSLRKIETPR 200
Cdd:cd17324 103 GFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGL-VLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKK 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 201 HMQnlttrekfSELGRAVTLLYTNRSIMLSSIVRIINTLSLFGFAVVMPMMFVDELGFTTSEWLQVWAAFFFTTIFSNVF 280
Cdd:cd17324 182 PGS--------LGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPL 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 281 WGVLAEKMGWMKVVRWFGCIGMALSSLAFyyipqhFGHNFAMALVPAIALGIFVAAFVPMAAVFPA-LEPKHKGAAISVY 359
Cdd:cd17324 254 AGRLADRGGRRALLIALLLLAAALLLLTL------LGPSPLLLLVGLVLWGLGFFAAHSALQTRVLrLAPEARGLASSLY 327
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 501081055 360 NLSAGLSNFLAPAIAVVLLPHFSTIGVVIAYTLLYIVAFILC 401
Cdd:cd17324 328 LAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLA 369
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
41-401 |
1.16e-08 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 56.42 E-value: 1.16e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 41 KALGFTPAEASFAFTLYGLAAALSAWVSGVVAEIITPQKTMMIGFVLWCVFHVLFLVfglgQSNYALILLFYGIRGLAYP 120
Cdd:cd17474 27 EALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGL----SDSFALLLAGRALQGIGAA 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 121 LFLYAFIVAIVHNVRSDSTSAALGWFWAVYSIGIGVF---GSYIPSftiphIGEMGTLWLALAFCLTGGVIALVSLRKIE 197
Cdd:cd17474 103 GLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGpllGGLLAA-----ISWRYPFFLLAALIPVAFLAILFLLPEPK 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 198 TPRHMQNLTTRekfselgRAVTLLYTNRSIMLSSIVRIINTLSLFGFAVVMPMMFVDELGFTTSEWLQVWAAFFFTTIFS 277
Cdd:cd17474 178 EKAKSSSATKL-------RDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALG 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 278 NVFWGVLAEKMGWMKVVRWFGCIGMALSSLAFYyipqhFGHNFAMALVPAIALGIFVAAFVP--MAAVFPALEPKHKGAA 355
Cdd:cd17474 251 SLFVGRLLKKRFGARRILVIGLLLYALSLLLLG-----FVPSLALLLIAIVLFGLGLGLNLPllTTLVTELAPEEERGTA 325
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 501081055 356 ISVYNLSAGLSNFLAPAIAVVLLPHFSTIGVVIAYTLLYIVAFILC 401
Cdd:cd17474 326 SSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLL 371
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
11-378 |
3.01e-08 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 55.29 E-value: 3.01e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 11 LPLSLVWGYIA--IAVFMTGDGFELAFLSHYIKALGFTPAEASFAFTLYGLAAALSAWVSGVVAEIITPQK-----TMMI 83
Cdd:COG2211 7 LSLKEKLAYGLgdLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWgrrrpWILI 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 84 GFVLWCV-FHVLFLVFGLGQS-NYALILLFYGIRGLAYPLF---LYAFIVAIVHNvrSDSTSAALGWFWAVYSIGiGVFG 158
Cdd:COG2211 87 GAIPLALsFVLLFTAPDLSPTgKLIYALVTYLLLGLAYTLVnipYSALGAELTPD--YEERTRLSSWRFAFAGLG-GLLA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 159 SYIPSFTIPHIGE---MGTLWLALAFCLTGGVIALVSLRKIETPRhmqnlTTREKFSELGRAVTLLYTNRSIMLSSIVRI 235
Cdd:COG2211 164 SVLPPPLVAAFGGdaaLGYRLTALIFAVLGLLAFLLTFFGTKERP-----VPEEEKVSLKESLKALLKNRPFLLLLLAYL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 236 INTLSLFGFAVVMPMMFVDELGFTTSEWLQVWAAFFFTTIFSNVFWGVLAEKMGWMKVVRWfGCIGMALSSLAFYYIPqh 315
Cdd:COG2211 239 LFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFII-GLLLAALGLLLLFFLG-- 315
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 501081055 316 fGHNFAMALVPAIALGIFVAAFVP-----MAAVFPALEPKHK----GAAISVYNLSAGLSNFLAPAIAVVLL 378
Cdd:COG2211 316 -PGNLWLLLVLAALAGIGLGAILVlpwamLADVVDYDEWKTGrrreGLYFGIFTFAIKLGQALAGALAGLLL 386
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
19-400 |
1.69e-07 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 52.98 E-value: 1.69e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 19 YIAIAVFMTGDGFELAFLSHYIKALGFTPAEASFAFTLYGLAAALSAWVSGVVAEIITPQKTMMIGFvlwCVFHVLFLVF 98
Cdd:cd17489 2 LLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGL---LIFALATLLY 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 99 GLGqSNYALILLFYGIRGLAYPLFLYAFIVAIVHNVRSDSTSAALGWFWAVYSIGIgVFGSYIPSFTIPHIGEMGTLWLA 178
Cdd:cd17489 79 LLA-TSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAM-ALGPALGLFLYQHLGFAVLFIVA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 179 LAFCLTGgvIALVSLRKIETPRHmqnlttrEKFSELGRAVTLLYTNRSIMLSSIVRIINTLSLFGFAVVMPmMFVDELGF 258
Cdd:cd17489 157 AVLALLA--LLLVFLVKDPPPVA-------AEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLP-LYAAERGI 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 259 TTsewlqvwAAFFFT-----TIFSNVFWGVLAEKMGwMKVVRWFGCIGMALSSLAFYyipqhFGHNFAMALVPAIALGIF 333
Cdd:cd17489 227 SN-------AGLFFTvyaiaLLLSRPFSGKLSDRKG-PKTVIIPGLLLLALGLLLLS-----FAGSPWMLLLAAVLYGLG 293
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 501081055 334 VAAFVPM--AAVFPALEPKHKGAAISVYNLSAGLSNFLAPAIAVVLLPHFSTIGVVIAYTLLYIVAFIL 400
Cdd:cd17489 294 FGLLFPAlqALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVL 362
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
43-401 |
3.07e-07 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 52.19 E-value: 3.07e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 43 LGFTPAEASFAFTLYGLAAALSAWVSGVVAEIITPQKTMMIgfVLwcVFHVLFLVFGLGQSNYALILLFYGIRGLAYPLF 122
Cdd:cd17504 26 FGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLI--VL--AIYTAGSLLAAFAPNLPVLIAGRALQGIGGAVF 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 123 LYAFIVaIVHNVRSDSTSAALGWFWAVYSIGIGVfGSYIPSFTIPHIGEMGTLWLALAFC-LTGGVIALVSLRkietprh 201
Cdd:cd17504 102 PLAFAL-VREEFPPERVPVAQGILSATFGIGAGI-GLPLGGWIVQHLGWRWIFWTAAPVAvLLAALVPLIDLR------- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 202 mqnlttrekfselgravtlLYTNRSIMLSSIVRIINTLSLFGFAVVMPMMFvdELGFTTSEWLQVWAAFFFTTIFSNVFW 281
Cdd:cd17504 173 -------------------LLRRRNVLLANITALLAGFGMFMVFQLLPQLL--QLPTPTGFGLGITEAGLLLLPGALVML 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 282 ------GVLAEKMGWMKVVRWfGCIGMALSSLAFYYIPQHFGHNFAMALVPAIALGIFVAAFVPMAAVfpALEPKHKGAA 355
Cdd:cd17504 232 iagplaGRLIARVGPRRVLLI-GLVISAVGLLLLALLHSSLWALVVALLLIGIGLGLAFASLPNIVVE--SVPPDRTGIA 308
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 501081055 356 ISVYNLSAGLSNFLAPAIAVVLLPHFSTIGVVI------AYTLLYIVAFILC 401
Cdd:cd17504 309 TGMNTVLRTIGSAIGPAIAGAILTTYTVSITSGgvptegAYVLAFLIGAALA 360
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
42-347 |
7.31e-07 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 51.03 E-value: 7.31e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 42 ALGFTPAEASFAFTLYGLAAALSAWVSGVVAEIITPQKTMMIGFVLWCVFHVLFLVFGlgqsNYALILLFYGIRGLAYpL 121
Cdd:COG2807 47 DLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAP----SVALLLAGTALIGAGI-A 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 122 FLYAFIVAIVHNVRSDSTSAALGwfwaVYSIGIGVFGSYIPSFTIPHIGEMGTLWLALAFCLTGGVIALVSLrkietpRH 201
Cdd:COG2807 122 VGNVLLPGLIKRWFPDRVGLMTG----LYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWL------PL 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 202 MQNLTTREKFSELGRAVTLLYTNRSIMLSSIVRIINTLSLFGFAVVMPMMFVDeLGFTTSEWLQVWAAFFFTTIFSNVFW 281
Cdd:COG2807 192 LRRRPAAAAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRD-AGLSAATAGLLLSLFQLAGIPGSLLV 270
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 501081055 282 GVLAEKMGWMKVVRWFGCIGMALSSLAFYYIPQhfghnfAMALVPAIALGIFVAAFVPMAAVFPAL 347
Cdd:COG2807 271 PLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPG------SLPWLWAVLLGLGQGGLFPLALTLIGL 330
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
225-401 |
7.53e-07 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 50.99 E-value: 7.53e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 225 RSIMLSSIVRIINTLSLFGFAVVMPMMFVDELGFTTSE--WLQVWAAFFFttIFSNVFWGVLAEKMGWMKVVRWfGCIGM 302
Cdd:cd17369 228 RALLLAIGLRLAENVLFYLFTTFALSYATQTLGVDRSTvlLAVLIASVVA--AITIPLFGWLSDRVGRRPVYLA-GALLA 304
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 303 ALSSLAFYYIPQhFGHNFAMALVPAIALGIFVAA-FVPMAAVFPALEPKH---KGAAISvYNLSAGLSNFLAPAIAVVLL 378
Cdd:cd17369 305 ALFAFPFFWLLD-TGSTWLIVLAAVVVLGVLHGMmYGPQAAFLAELFPTRvryTGASLG-YQLGAILGGGFAPLIATALV 382
|
170 180
....*....|....*....|...
gi 501081055 379 PHFSTIGVVIAYTLLYIVAFILC 401
Cdd:cd17369 383 AATGSWWPVALYLAALAVISLVA 405
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
231-401 |
1.32e-06 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 50.11 E-value: 1.32e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 231 SIVRIINTLSLFGFAVVMPMMFVDELGFTTSEWLQVWAAFFFTTIFSNVFWGVLAEKMGwmkvVRWFGCIGMALSSLAFY 310
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFG----RRRVLLIGLLLFALGLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 311 YIPqhFGHNFAMALVPAIALGIFVAAFVPMAAVFPA--LEPKHKGAAISVYNLSAGLSNFLAPAIAVVLLPHFSTIGVVI 388
Cdd:pfam07690 78 LLL--FASSLWLLLVLRVLQGLGAGALFPAALALIAdwFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFL 155
|
170
....*....|...
gi 501081055 389 AYTLLYIVAFILC 401
Cdd:pfam07690 156 ILAILSLLAAVLL 168
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
222-400 |
2.34e-06 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 49.48 E-value: 2.34e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 222 YTNRSIMLSSIVRIINTLSLFGFAVVMPMMfVDELGFTTSEWLQVWAAFFFTTIFSNVFWGVLAEKMGwmkvVRWFGCIG 301
Cdd:COG2271 7 YRWRILALLFLAYFLNYLDRSNLSVAAPPL-QADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFG----RRRVLAIG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 302 MALSSLAFYYIPqhFGHNFAMALVPAIALGIFVAAFVPMAAVFPAL--EPKHKGAAISVYNLSAGLSNFLAPAIAVVLLP 379
Cdd:COG2271 82 LLLWGLATLLFG--FATSFWQLLLLRFLLGLGEAGFFPAALKLIAEwfPPKERGRALGIFNAGGPLGGALAPPLLGWLLA 159
|
170 180
....*....|....*....|.
gi 501081055 380 HFSTIGVVIAYTLLYIVAFIL 400
Cdd:COG2271 160 AFGWRAAFLILGLPGLLLALL 180
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
41-356 |
2.38e-06 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 49.17 E-value: 2.38e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 41 KALGFTPAEASFAFTLYGLAAALSAWVSGVVAEIITPQKTMMIGFVLWCVFHVLFLVFGLGQSNYALILLFYGIRGlayp 120
Cdd:cd17341 27 DDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALALAVSSYWGLLVLGFLLGFAG---- 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 121 lflyAFIVAIVHNVRSDSTSAALGWFWAVYSiGIGVFGSYIPSFTIPHI-----GEMGTLWLALAFCLTGGVIALVSlrk 195
Cdd:cd17341 103 ----ANFASGQPWASFWFPKEKIGGAAGGIA-GAGNMGVAVSQLLAPLIagaivFDGGFVGWRNAFFVPGILLAIAA--- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 196 IETPRHMQNLTTREKFSELGRAVTL-LYTNRSIMLSSIVRIINTLSLFGFAVVMPMMFVDELGFTTSEWLQVWAAFFFTT 274
Cdd:cd17341 175 VLVLLFGDDLPTGKASALEFLKVQLaVLKNYRTWILSLLYGVTFGSFVGFSNVLPTYFKTRFGLPLVTAGILAALFPLAG 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 275 IFSNVFWGVLAEKMGwMKVVRWFGCIGMALSSLAFYYIPQHFGHNFAMALVPAIALGIFV-AAFVPMAAVFPALEPKHKG 353
Cdd:cd17341 255 ALARPAGGWLSDRFG-GRRRLWWLFIVMTIGAALLSLSLPTSGTNLVLFLALFVALGLGAgAGNGSVFRMVPFIFRRELG 333
|
...
gi 501081055 354 AAI 356
Cdd:cd17341 334 AVT 336
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
233-409 |
6.58e-06 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 47.97 E-value: 6.58e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 233 VRIINTLSLFGFAVVMPMM--FVDELGFTTSEWLQVWAAFFFTTIFSNVFWGVLAEKMGWMKVVRwFGCIGMALSSLAFY 310
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLplYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLL-IGLLIFALATLLYL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 311 yipqhFGHNFAMALVPAIALGIFVAAFVPMAA--VFPALEPKHKGAAISVYNLSAGLSNFLAPAIAVVLLPHFSTIGVVI 388
Cdd:cd17489 80 -----LATSVALLLVLRLIHGIGWGAFTTAAAtlVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFI 154
|
170 180
....*....|....*....|.
gi 501081055 389 AYTLLYIVAFILCPFIRVEQP 409
Cdd:cd17489 155 VAAVLALLALLLVFLVKDPPP 175
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
15-400 |
1.37e-05 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 46.84 E-value: 1.37e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 15 LVWGYIAIAVFMTGDGFELAFLS-HYIKALGFTPAEASFAFTLYGLAAALSAWVSGVVAEIITPQKTMMIGFVLWCVFhv 93
Cdd:cd17329 1 LWVLLIGSFLNRLGFFMVWPFMAiYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALG-- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 94 lFLVFGLGQSNYALILLFYGIrGLAYPLFLYAFIVAIVHNVRSDSTSAALGWFWAVYSIGIGVfGSYIPSFtiphigeMG 173
Cdd:cd17329 79 -FALLGFAHSPWLFAIALVLT-GFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAI-GPLLGGL-------LL 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 174 TLWLALAFCLTGGVIALVSLRKIETPRHMQNLTTREKFSELGRAVTLLYTNRSIMLSSIVRIINTLSLFGFAVVMPMMFV 253
Cdd:cd17329 149 LYSFRLLFLAAAVLFLLAALVLLFLLPETRPKRRAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVV 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 254 DELGFTTSEWLQVWAAFFFTTIFSNVFWGVLAEKMGwMKVVRWFGCIGMALSSLAFYyipqhFGHNFAMALVPAIALGIF 333
Cdd:cd17329 229 EILGLGESLLGLLLALNALLIVLLQFPVARLVERFR-LRKILMIGILLFAIGFAVLA-----FANTLAVLILAMIVLTLG 302
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 501081055 334 VAAFVPMAAVF-PALEPKHK-GAAISVYNLSAGLSNFLAPAIAVVLLPHFSTIGVVIAYTLLYIVAFIL 400
Cdd:cd17329 303 EMLVFPAVQTLvAALAPPDKrGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAAL 371
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
235-400 |
1.62e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 46.51 E-value: 1.62e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 235 IINTLSLFGFAVVMPMM--FVDELGFTTSEWLQVWAAFFFTTIFSNVFWGVLAEKMGWMKVVRWfGCIGMALSSLAFYyi 312
Cdd:COG2814 17 LGAFLSGLGIGIVLPALplIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLL-GLLLFALGSLLCA-- 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 313 pqhFGHNFAMALVPAIALGIFVAAFVP--MAAVFPALEPKHKGAAISVYNLSAGLSNFLAPAIAVVLLPHFSTIGVVIAY 390
Cdd:COG2814 94 ---LAPSLWLLLAARFLQGLGAGALFPaaLALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVN 170
|
170
....*....|
gi 501081055 391 TLLYIVAFIL 400
Cdd:COG2814 171 AVLALLALLL 180
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
6-190 |
1.76e-05 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 46.77 E-value: 1.76e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 6 KQWLGLPLSLvWGYIAIAVFMTGDGFELAFLSHYIKALGFTPAEASFAFTLYGLAAALSAWVSGVVAEIITPQKTMMIGF 85
Cdd:cd17370 193 TSLKKLPKAF-WLYLLAVALFALGNFSFAFLILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGY 271
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 86 VLWCvfhVLFLVFGLGQSNYALILLFYgIRGLAYPLFLYAFIVAIVHNVRSDSTSAALGWFWAVYSIGIgVFGSYIPSFT 165
Cdd:cd17370 272 LSLA---LAYLGFALGSSLWLLLLGFI-LWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGW-LLASLIAGYL 346
|
170 180
....*....|....*....|....*
gi 501081055 166 IPHIGEMGTLWLALAFCLTGGVIAL 190
Cdd:cd17370 347 WDLISPSAAFLFSAVLALIALLLLL 371
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
20-190 |
1.45e-04 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 43.74 E-value: 1.45e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 20 IAIAVFMTGDGFELAFLSHYIKALGFTPAEASFAFTLYGLAAALSAWVSGVVAEIITPQKTMMIGFVLWCVFHVLFLVFG 99
Cdd:cd17316 185 LWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLL 264
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 100 LGQSNYALILLFYGIRGLAYPLFLYAFIVAIVHNVRSDSTsaALGWFWAVYSIGIGVFGSYIPSFTIPHIGEMGTLWLAL 179
Cdd:cd17316 265 SGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRAT--GVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILA 342
|
170
....*....|.
gi 501081055 180 AFCLTGGVIAL 190
Cdd:cd17316 343 LLAIVALIVAL 353
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
4-191 |
1.47e-04 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 43.72 E-value: 1.47e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 4 TNKQWLGLPLSLVWGYIAIAVFMTGDGFELAFLSHYIKAL-GFTPAEASFAFTLYGLAAALSAWVSGVVAEIITPQKTMM 82
Cdd:cd17325 190 SGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELgGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLIL 269
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 83 IGFVLWCVFHVLFLVFglgqSNYALILLFYGIRGLAYPLFLYAFIVAIVHNVRSDSTSAALGWFWAVYSIGIgVFGSYIP 162
Cdd:cd17325 270 IGLLLSAVALLLLPLA----TSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGM-VLGPLLG 344
|
170 180
....*....|....*....|....*....
gi 501081055 163 SFTIPHIGEMGTLWLALAFCLTGGVIALV 191
Cdd:cd17325 345 GFLYDAFGFATPFLAAAALLLLAAVLFLL 373
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
30-404 |
3.28e-04 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 42.54 E-value: 3.28e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 30 GFELAFLSHYIKALGFTPAEASFAFTLYGLAAALSAWVSGVVAEIITPQKTMMIGFVLWCVFHVLFLVFglgqSNYALIL 109
Cdd:cd17478 13 GFLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFA----PNYWLLL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 110 LFYGIRGLAYPLFlYAFIVAIVHNVRSDSTSAALGWFWAVYSIGIGVFGSYIPSFTIPHIGEMGTLWLALAFCLTGGVIA 189
Cdd:cd17478 89 LLVALAGIGSAAF-HPEGARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 190 LVS-LRKIETPRHMQNLTTREKFSELGRAVTLLytNRSIMLSSIVriintlsLFGFAVVMPMMFVDElGFTTSEWLQVWA 268
Cdd:cd17478 168 RLRpLKKPEAKKAAAKSSARSTLKGVWRALLLL--LIIVFLRSWV-------LSSLTTFLPFYLVQR-GYSLVFAGLLLS 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 269 AFFFTTIFSNVFWGVLAEKMGWMKVVrWFGCIGMALSSLAFYYIPqhfghNFAMALVPAIALGIFVAAFVPMAAVFPALE 348
Cdd:cd17478 238 LFLFAGAIGTLIGGPLSDRFGRRRVI-IASLLLAAPFLLLFLLTP-----GIWSYILLVLAGFLLFASFPVTVVLAQELL 311
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 501081055 349 PKHKGAAISVYNlsaGLSNFLAPAIAVVLLPHFSTIGVVIAYTLLYIVAFILCPFI 404
Cdd:cd17478 312 PGNVGLASGLMM---GLSFGLGGIGAPVLGALADAFGLESVLLILALLPLLGALLA 364
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
225-416 |
7.49e-04 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 41.40 E-value: 7.49e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 225 RSIMLSSIVRIINTLSLFGFAVVMPMMfVDELGFTTSEWLQVWAAFFFTTIFSNVFWGVLAEKMGwmkvVRWFGCIGMAL 304
Cdd:COG2223 5 RVLLLATLAFFLAFGVWYLWSVLAPPL-AEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFG----PRRVLLIGLLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 305 SSLAFYYIPqhFGHNFAMALVPAIALGIFVAAF--VPMAAVFPALEPKHKGAAISVYNLSAGLSNFLAPAIAVVLLPHFS 382
Cdd:COG2223 80 LGIGLLLLA--LAVSYWLLLLLGLLLGIGGGGSfaVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFG 157
|
170 180 190
....*....|....*....|....*....|....
gi 501081055 383 TIGVVIAYTLLYIVAFILCPFIRVEQPGFTRQEA 416
Cdd:COG2223 158 WRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAA 191
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
16-156 |
1.50e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 40.62 E-value: 1.50e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 16 VWGYIAIAVFMTGDGFELAFLSHYIK-ALGFTPAEASFAFTLYGLAAALSAWVSGVVAEIITPQKTMMIGFVLWCVFhVL 94
Cdd:cd17321 171 SGAVLAAFLLGAALGGLLFLLPLYLQgVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVG-LL 249
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 501081055 95 FLVFGLGQSNYALILLFYGIRGLAYPLFLYAFIVAIVHNVRSDSTSAALGWFWAVYSIGIGV 156
Cdd:cd17321 250 LLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGAL 311
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
266-409 |
1.87e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 40.29 E-value: 1.87e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 266 VWAAFFFTTIFSNVFWGVLAEKMGWMKVVRWFGcIGMALSSLAFYYIPQHFGHNFAMALVPAIALGIFVAAFVP-MAAVF 344
Cdd:cd06173 39 VLAAFFLPFLLFSPFAGVLADRFDRRRLLILAD-LLRALLAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGPaRQALL 117
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 501081055 345 PALEPKHK-GAAISVYNLSAGLSNFLAPAIAVVLLPHFSTIGVVIAYTLLYIVAFILCPFIRVEQP 409
Cdd:cd06173 118 PELVPKEQlVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLFIRRPPP 183
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
22-201 |
2.02e-03 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 40.25 E-value: 2.02e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 22 IAVFMTGDGFELAFLSHYIKALGFTPAEASFAFTLYGLAAALSAWVSGVVAEIITPQKTMMIGFVLWCVFhvLFLVFGLG 101
Cdd:COG2223 215 FGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALG--LLLLALAL 292
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 102 QSNYALILLFYGIrGLAYPLFLYAFIVAIVHNVRSDSTSAALGWFWAVYSIGiGVFGSYIPSFTIPHIGE-MGTLWLALA 180
Cdd:COG2223 293 GSLWLFLVLFLLL-GLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLG-GFLGPLLFGALLDATGSyTAAFLVFAV 370
|
170 180
....*....|....*....|.
gi 501081055 181 FCLTGGVIALVSLRKIETPRH 201
Cdd:COG2223 371 LALVALVLTLLLYRRPRRAAA 391
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
185-401 |
3.50e-03 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 39.48 E-value: 3.50e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 185 GGVIALVSLRKIETPRHMQNLTTRekFSELGRAVTLLYTNRSIMLSSIVRIINTLSLFGFAVVMPMMFVDELGFTTSEWL 264
Cdd:cd17320 163 GLLLLLLVLLFLPETLPEEKRKPL--LSSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFG 240
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 265 QVWAAFFFTTIFSNVFWGVLAEKMGWMKVVRWFGCIGMALSSLAFYYIPQHFGHNFAMALVPAIALGIFVAAFVPMAAVF 344
Cdd:cd17320 241 LLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLA 320
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 501081055 345 PALEPKHKGAAISVYNLSAGLSNFLAPAIaVVLLPHFSTIGVVIAYTLLYIVAFILC 401
Cdd:cd17320 321 LEPFPHVAGTASALLGFLQFLIGALAGAL-VGLLPNGTALPMGLLILVLGLLALLLL 376
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
35-393 |
3.62e-03 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 39.18 E-value: 3.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 35 FLSHYIKALGFTPAEASFAFTLYGLAAALSAWVSGVVAEIITPQKTMMIGFVLWCvfhVLFLVFGLGQSNYALILLFYGI 114
Cdd:cd17355 25 FIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLA---AGLVLLALATSLWQLYLLWGLL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 115 RGLAYPLFLYAFIVAIVHNVRSDSTSAALGWFWAVYSIGiGVFGSYIPSFTIPHIGEMGTLwLALAFCLTGGVIALVSLR 194
Cdd:cd17355 102 GGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLG-SLVFLPLGAALIEAFGWRTAL-LVLALLALLVLVPVLLLL 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 195 KIETPRHMQNLTTREKFSELGRAVTLLYTNRSIMLSSIVRIINTLSLFGFAVVMPMMFVDeLGFTTSEWLQVWAAFFFTT 274
Cdd:cd17355 180 RRRPADLALRAYDDASPASPGSTLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLAD-RGISPAAAAVALALIGLFN 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 275 IFSNVFWGVLAEKmgWMKVVRWFGCIGMALSSLAFYYIpqhFGHNFAMALVPAIALGIFVAAFVPMAAVFPALE--PKHK 352
Cdd:cd17355 259 IVGRLLSGWLGDR--YSPRRLLAASYALRALGLALLLL---LPFPPLALLLFAALFGLGWGATVPLTAALAARYfgARSY 333
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 501081055 353 GAAISVYNLSAGLSNFLAPAIAVVLLPHFSTIGVVIAYTLL 393
Cdd:cd17355 334 GTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVA 374
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
236-400 |
3.66e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 39.45 E-value: 3.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 236 INTLSLFGFAvvMPMMFVDELGFTTSEWLQVWAAFFFTTIFSNVFWGVLAEKMGwMKVVRWFGCIGMALSSLAFYyipqh 315
Cdd:cd17370 211 LFALGNFSFA--FLILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIG-RKKLLILGYLSLALAYLGFA----- 282
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 316 FGHNFAMALVPAIALGIFVAAF--VPMAAVFPALEPKHKGAAISVYNLSAGLSNFLAPAIAVVLLPHFSTIGVVIAYTLL 393
Cdd:cd17370 283 LGSSLWLLLLGFILWGLYMGAQesIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVL 362
|
....*..
gi 501081055 394 YIVAFIL 400
Cdd:cd17370 363 ALIALLL 369
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
15-157 |
3.66e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 39.32 E-value: 3.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 15 LVWGYIAIAVFMTGDGFELAFLSHYIKALGFTPAEASFAFTLYGLAAALSAWVSGVVAEIITPQKTMMIGFVLwCVFHVL 94
Cdd:pfam07690 202 VLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLL-LILAAL 280
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 501081055 95 FLVFGLGQSNYALILLFYGIRGLAYPLFLYAFIVAIVHNVRSDSTSAALGWFWAVYSIGIGVF 157
Cdd:pfam07690 281 GLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
217-401 |
4.68e-03 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 38.74 E-value: 4.68e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 217 AVTLLYTNRSIMLSSIVRIINTLSLFGFAVVMPMMFVDELGFTTSEWLQVWAAFFFTTIFSNVFWGVLAEKMGwMKVVRW 296
Cdd:cd17316 169 ALLALLLRRRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIG-RKKTLV 247
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 297 FGCIGMALSSLAFYYIPQhfGHNFAMALVPAIALGIFVAAFVPMAAVFPALEPKH-KGAAISV-YNLSAGLSNFLAPAIA 374
Cdd:cd17316 248 IGLILSGILALPLFYLLS--GSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEvRATGVGLsYNLGRLGGGGAPPLIA 325
|
170 180
....*....|....*....|....*..
gi 501081055 375 VVLLPHFSTIGVVIAYTLLYIVAFILC 401
Cdd:cd17316 326 LLLASTGGTGVPALILALLAIVALIVA 352
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
254-382 |
4.78e-03 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 38.71 E-value: 4.78e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 254 DELGFTTSEWLQVWAAFFFTTIFSNVFWGVLAEKMGwmkvVRWFGCIGMALSSLAfyYIPQHFGHNFAMALVPAIALGIF 333
Cdd:cd17319 31 KDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFG----ARKVLAVSMLLWSLF--TALTGFATSLTSLYVLRFLLGVA 104
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 501081055 334 VAAFVPMAAVFPALE--PKHKGAAISVYNLSAGLSNFLAPAIAVVLLPHFS 382
Cdd:cd17319 105 EAGFFPGAIKALAEWfpARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFG 155
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
19-400 |
7.44e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 38.31 E-value: 7.44e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 19 YIAIAVFMTGDGFELAFLSHYIKALGFTPAEASFAFTLYGLAAALSAWVSGVVAEIITPQKTMMIGFVLWCvfhVLFLVF 98
Cdd:cd17477 2 LLSVALLGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITA---VSVLLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 99 GLGQSNYALILLFYgIRGLAYPLFLYAFIVAIVHNVRSDSTSAALGWFWAVYSIGIGVFGsyipsFTIPHIGEMGTLWLA 178
Cdd:cd17477 79 ALTDSPWVWFLLRF-VMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGP-----LLLALVGTAGALPFL 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 179 LAFCLTGGVIALVSLRKIETPRHMQNlttrekfsELGRAVTLLYTNRSIMLSSIVRIINTLSLFGFAVVmpmmFVDELGF 258
Cdd:cd17477 153 IAAVLLLLALVPLLLTRRAAPEIEEA--------ESISLRRLLRIAPLALLGAFVAGFLEGAFYSLLPL----YGLRLGL 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 259 TTSEWLQVWAAFFFTTIFSNVFWGVLAEKMGWMKVVRWFGCIGMALSSLAFYyipqhFGHNFAMALVPAIALGIFVAAFV 338
Cdd:cd17477 221 SVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPL-----VPGLPLALLVLLFLWGGAAGPLY 295
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 501081055 339 P--MAAVFPALEPKHKGAAISVYNLSAGLSNFLAPAIAVVLLPHFSTIGVVIAYTLLYIVAFIL 400
Cdd:cd17477 296 TlaLALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLF 359
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
19-191 |
8.24e-03 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 38.33 E-value: 8.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 19 YIAIAVFMTGDGFELAFLSHYIKALGFTPAEASFAFTLYGLAAALSAWVSGVVAEIITPQKTMMIGFVlwcVFHVLFLVF 98
Cdd:cd17335 204 LLVAFLMGFGHGLIYSFLFWHLQDLGGSKTLIGLLWTVGVVSEIPFFFFSSRLIQRFGHVGLLYLGLL---AYVVRWLLY 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 99 GLGqSNYALILLFYGIRGLAYPLFLYAFIVAIVHNVRSDSTSAALGWFWAVYSIGIGVFGSYIPSFTIPHIGEMGTLWLA 178
Cdd:cd17335 281 SFL-ENPWLVLPIELLHGLTFALVWAAAVSYASAAAPPGLRATAQGLLQGLYFGLGGGLGSLIGGYLYEAFGARTTFRFF 359
|
170
....*....|...
gi 501081055 179 LAFCLTGGVIALV 191
Cdd:cd17335 360 AIAALAGLLAFFL 372
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
41-404 |
9.24e-03 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 37.94 E-value: 9.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 41 KALGFTPAEASFAFTLYGLAAALSAWVSGVVAEIITPQKTMMIGFVLWCVFHVLFLVFGlgqsNYALILLFYGIRGLAYP 120
Cdd:cd17319 31 KDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFAT----SLTSLYVLRFLLGVAEA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 121 LFLYAFIVAIVHNVRSDSTSAALGwfwaVYSIGIGVFGSYIPSFTIPHIGEMGTLWLALAFCLTGGVIALVSLRKIetpr 200
Cdd:cd17319 107 GFFPGAIKALAEWFPARERGRATG----LFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYL---- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 201 hmqnlttrekfselgravtllytnRSIMLSSIVRIINTLSLFGFAVVMPMMFVDELGFTTSEWLQVWAAFFFTTIFSNVF 280
Cdd:cd17319 179 ------------------------RQVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMIL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501081055 281 WGVLAEKMGWMKVvRWFGCIGMALSSLAFYYIPqhFGHNFAMALVPAIALGIFVAAFVPMAAVFPA--LEPKHKGAAISV 358
Cdd:cd17319 235 GGRLSDRLLRGAR-RLVIIIGLLLAAVGLLLAY--LTTSPVVAVILLSLAGFGIGAASPVFWSLPAdlLPGEAAATAGGL 311
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 501081055 359 YNLSAGLSNFLAPAIavvllphfstIGVVIAYTLLYIVAFILCPFI 404
Cdd:cd17319 312 INSGGNLGGFVAPLL----------IGYLVDATGSYTAAFLFLAAV 347
|
|
| |
