|
Name |
Accession |
Description |
Interval |
E-value |
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
4-439 |
0e+00 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 871.92 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 4 MRFSPRSSFARTLLLIVTLLFVSLVTTYLVVLNFAILPSLQQFNKVLAYEVRMLMTDklQLEDGTQLVVPPAFRREIYRE 83
Cdd:PRK09467 1 MRFSPRSSFARTLLLIVTLLFISQVVSYLVVLNYAILPSLQQFNKVLAYEVRLLFTD--QLEDGTQLVVPPAFRREIYRE 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 84 LGISLYSNEAAEEAGLRWAQHYEFLSHQMAQQLGGPTEVRVEVNKSSPVVWLKTWLSPNIWVRVPLTEIHQGDFSPLFRY 163
Cdd:PRK09467 79 LGISLYSNEAAEEAGLRWAQHYEFLSEQMSQQLGGPTEVRVEVGKESPIVWIKTPLAPNIWVRVPLTEIHQGDFSPLFRY 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 164 TLAIMLLAIGGAWLFIRIQNRPLVDLEHAALQVGKGMIPPPLREYGASEVRSVTRAFNHMAAGVKQLADDRTLLMAGVSH 243
Cdd:PRK09467 159 TLAIGLLSVAGGWLFIRIQNRPLVALEHAALQVGKGEIPPPLREYGASEVRSVTRAFNQMAAGIKQLEDDRTLLMAGVSH 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 244 DLRTPLTRIRLATEMMGEEDGYLAESINKDIEECNAIIEQFIDYLRTGQEMPMEMADLNAVLGEVIAAESGYEREIDTAL 323
Cdd:PRK09467 239 DLRTPLTRIRLATEMMSEEDGYLAESINKDIEECNAIIEQFIDYLRTGQEMPMEMADLNALLGEVIAAESGYEREIETAL 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 324 QPGSIQVKMHPLSIKRAIANMVVNAARYGNGWIKVSSGTEPHRAWFQVEDDGPGIKPEQRKHLFQPFVRGDSARSTSGTG 403
Cdd:PRK09467 319 QPGPIEVPMNPIAIKRALANLVVNAARYGNGWIKVSSGTEGKRAWFQVEDDGPGIPPEQLKHLFQPFTRGDSARGSSGTG 398
|
410 420 430
....*....|....*....|....*....|....*.
gi 501085031 404 LGLAIVQRIVDNHNGMLEIGSSERGGLSIRAWLPIP 439
Cdd:PRK09467 399 LGLAIVKRIVDQHNGKVELGNSEEGGLSARAWLPLT 434
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
337-437 |
1.14e-54 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 177.26 E-value: 1.14e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 337 IKRAIANMVVNAARYGNGWIKVSSGTEPHRAWFQVEDDGPGIKPEQRKHLFQPFVRGDSARSTSGTGLGLAIVQRIVDNH 416
Cdd:cd16950 1 LKRVLSNLVDNALRYGGGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARGTSGTGLGLAIVQRISDAH 80
|
90 100
....*....|....*....|.
gi 501085031 417 NGMLEIGSSERGGLSIRAWLP 437
Cdd:cd16950 81 GGSLTLANRAGGGLCARIELP 101
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
219-438 |
1.48e-53 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 179.33 E-value: 1.48e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 219 AFNHMAAGVKQLADDRTLLMAGVSHDLRTPLTRIRLATEMMGEEDGY-------LAESINKDIEECNAIIEQFIDYLRT- 290
Cdd:COG2205 1 ELEEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLspeerreLLEIIRESAERLLRLIEDLLDLSRLe 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 291 --GQEMPMEMADLNAVLGEVIA----AESGYEREIDTALQPGSIQVKMHPLSIKRAIANMVVNAARYG--NGWIKVSSGT 362
Cdd:COG2205 81 sgKLSLELEPVDLAELLEEAVEelrpLAEEKGIRLELDLPPELPLVYADPELLEQVLANLLDNAIKYSppGGTITISARR 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 501085031 363 EPHRAWFQVEDDGPGIKPEQRKHLFQPFVRGDSARSTSGTGLGLAIVQRIVDNHNGMLEIGSSERGGLSIRAWLPI 438
Cdd:COG2205 161 EGDGVRISVSDNGPGIPEEELERIFERFYRGDNSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPL 236
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
132-439 |
1.51e-52 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 179.33 E-value: 1.51e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 132 VVWLKTWLSPNIWVRVPLTEIHQGDFSPLFRYTLAIMLLAIGGAWLFIRIQNRPLVDLEHAALQVGKGMIPPPLREYGAS 211
Cdd:COG0642 8 LVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 212 EVRSVTRAFNHMAAGVKQLADDRTLLMAGVSHDLRTPLTRIRLATEMM----GEEDGYLAESINKDIEECNAIIEQFIDY 287
Cdd:COG0642 88 LLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLleelDEEQREYLETILRSADRLLRLINDLLDL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 288 LRTGQ---EMPMEMADLNAVLGEVIAA-ESGYER---EIDTALQPGSIQVKMHPLSIKRAIANMVVNAARYG--NGWIKV 358
Cdd:COG0642 168 SRLEAgklELEPEPVDLAELLEEVVELfRPLAEEkgiELELDLPDDLPTVRGDPDRLRQVLLNLLSNAIKYTpeGGTVTV 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 359 SSGTEPHRAWFQVEDDGPGIKPEQRKHLFQPFVRGDSARSTSGTGLGLAIVQRIVDNHNGMLEIGSSERGGLSIRAWLPI 438
Cdd:COG0642 248 SVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSRRGGGTGLGLAIVKRIVELHGGTIEVESEPGKGTTFTVTLPL 327
|
.
gi 501085031 439 P 439
Cdd:COG0642 328 A 328
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
121-438 |
4.36e-50 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 174.74 E-value: 4.36e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 121 EVRVEVNKSSPVVWLKTWLSPNIWVRVPLTEIHQGDFSPLFRYTLAIMLLAIGGAWLFIRIQNRPLVDLEHAALQVGKGM 200
Cdd:COG5002 52 LALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLLL 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 201 IPPPLREYGASEVRSVTRAFNHMAAGVKQLADDRTLLMAGVSHDLRTPLTRIRLATEMM-------GEEDGYLAESINKD 273
Cdd:COG5002 132 GRLSLRLSALLLGLLLLAAVERDITELERLEQMRREFVANVSHELRTPLTSIRGYLELLldgaaddPEERREYLEIILEE 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 274 IEECNAIIEQFIDY--LRTGQ-EMPMEMADLNAVLGEVI------AAESGYEreIDTALQPGSIQVKMHPLSIKRAIANM 344
Cdd:COG5002 212 AERLSRLVNDLLDLsrLESGElKLEKEPVDLAELLEEVVeelrplAEEKGIE--LELDLPEDPLLVLGDPDRLEQVLTNL 289
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 345 VVNAARYG--NGWIKVSSGTEPHRAWFQVEDDGPGIKPEQRKHLFQPFVRGDSARS--TSGTGLGLAIVQRIVDNHNGML 420
Cdd:COG5002 290 LDNAIKYTpeGGTITVSLREEDDQVRISVRDTGIGIPEEDLPRIFERFYRVDKSRSreTGGTGLGLAIVKHIVEAHGGRI 369
|
330
....*....|....*...
gi 501085031 421 EIGSSERGGLSIRAWLPI 438
Cdd:COG5002 370 WVESEPGKGTTFTITLPL 387
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
165-439 |
2.68e-43 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 157.46 E-value: 2.68e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 165 LAIMLLAIGGA---WLFIRIQNRPLVDLEHAALQVGKGMIPPPLREYGASEVRSVTRAFNHMAAGVKQLADDRTLLMAGV 241
Cdd:PRK10604 140 ALLALIGLSLAfpvFLWMRPHWQDMLKLEAAAQRLGDGHLAERIHFDEGSSLERLGVAFNQMADNINALIASKKQLIDGI 219
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 242 SHDLRTPLTRIRLATEMMGEEDGYLAESINKDIEECNAIIEQFIDYLRTG-QEMPMEMADLN------AVLGEVIAAESG 314
Cdd:PRK10604 220 AHELRTPLVRLRYRLEMSDNLSAAESQALNRDIGQLEALIEELLTYARLDrPQNELHLSEPDlpawlsTHLADIQAVTPE 299
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 315 YEREIDTALQPGSIQVKMHPLSikRAIANMVVNAARYGNGWIKVSSGTEPHRAWFQVEDDGPGIKPEQRKHLFQPFVRGD 394
Cdd:PRK10604 300 KTVRLDTPHQGDYGALDMRLME--RVLDNLLNNALRYAHSRVRVSLLLDGNQACLIVEDDGPGIPPEERERVFEPFVRLD 377
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 501085031 395 SA--RSTSGTGLGLAIVQRIVDNHNGMLEIGSSERGGLSIRAWLPIP 439
Cdd:PRK10604 378 PSrdRATGGCGLGLAIVHSIALAMGGSVNCDESELGGARFSFSWPVW 424
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
237-438 |
2.27e-37 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 141.25 E-value: 2.27e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 237 LMAGVSHDLRTPLTRIRLATEMM--------GEEDGYLAES---INKDIEECNAIIEQFIDYLRtgqeMP---MEMADLN 302
Cdd:COG5000 204 LARRIAHEIKNPLTPIQLSAERLrrkladklEEDREDLERAldtIIRQVDRLKRIVDEFLDFAR----LPepqLEPVDLN 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 303 AVLGEVIAA-ESGYER---EIDTALQPGSIQVKMHPLSIKRAIANMVVNA--ARYGNGWIKVSSGTEPHRAWFQVEDDGP 376
Cdd:COG5000 280 ELLREVLALyEPALKEkdiRLELDLDPDLPEVLADRDQLEQVLINLLKNAieAIEEGGEIEVSTRREDGRVRIEVSDNGP 359
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 501085031 377 GIKPEQRKHLFQPFVrgdsarST--SGTGLGLAIVQRIVDNHNGMLEIGSSERGGLSIRAWLPI 438
Cdd:COG5000 360 GIPEEVLERIFEPFF------TTkpKGTGLGLAIVKKIVEEHGGTIELESRPGGGTTFTIRLPL 417
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
176-442 |
3.32e-35 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 135.83 E-value: 3.32e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 176 WLFIRIqNRPLVDLEHAALQVGKG--MIPPPLrEYGASEVRSVTRAFNHMAAGVKQLADDRTLLMAGVSHDLRTPLTRIR 253
Cdd:PRK09470 185 WLAWSL-AKPARKLKNAADEVAQGnlRQHPEL-ETGPQEFRQAGASFNQMVTALERMMTSQQRLLSDISHELRTPLTRLQ 262
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 254 LATEMMGEEDGYLAE--SINKDIEEcnaiIEQFIDYL----RT--GQEMPMEMADLNAVLGEVI------AAESGYEREI 319
Cdd:PRK09470 263 LATALLRRRQGESKEleRIETEAQR----LDSMINDLlvlsRNqqKNHLERETFKANSLWSEVLedakfeAEQMGKSLTV 338
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 320 DTalQPGSIQVKMHPLSIKRAIANMVVNAARYGNGWIKVSSGTEPHRAWFQVEDDGPGIKPEQRKHLFQPFVRGDSAR-- 397
Cdd:PRK09470 339 SA--PPGPWPINGNPNALASALENIVRNALRYSHTKIEVAFSVDKDGLTITVDDDGPGVPEEEREQIFRPFYRVDEARdr 416
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 501085031 398 STSGTGLGLAIVQRIVDNHNGMLEIGSSERGGLSIRAWLPIPVAR 442
Cdd:PRK09470 417 ESGGTGLGLAIVENAIQQHRGWVKAEDSPLGGLRLTIWLPLYKRS 461
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
337-436 |
1.76e-33 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 121.56 E-value: 1.76e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 337 IKRAIANMVVNAARYG--NGWIKVSSGTEPHRAWFQVEDDGPGIKPEQRKHLFQPFVRGDSARSTSGTGLGLAIVQRIVD 414
Cdd:cd00075 1 LEQVLSNLLDNALKYSppGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKSREGGGTGLGLAIVRRIVE 80
|
90 100
....*....|....*....|..
gi 501085031 415 NHNGMLEIGSSERGGLSIRAWL 436
Cdd:cd00075 81 AHGGRITVESEPGGGTTFTVTL 102
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
237-438 |
7.69e-33 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 127.61 E-value: 7.69e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 237 LMAGVSHDLRTPLTRIRLATEMM---------GEEDGYLAESINKDIEECNAIIEQFIDYLRtGQEMPMEMADLNAVLGE 307
Cdd:COG4191 145 LAAGIAHEINNPLAAILGNAELLrrrledepdPEELREALERILEGAERAAEIVRSLRAFSR-RDEEEREPVDLNELIDE 223
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 308 VIA-AESGYER---EIDTALQPGSIQVKMHPLSIKRAIANMVVNAA----RYGNGWIKVSSGTEPHRAWFQVEDDGPGIK 379
Cdd:COG4191 224 ALElLRPRLKArgiEVELDLPPDLPPVLGDPGQLEQVLLNLLINAIdameEGEGGRITISTRREGDYVVISVRDNGPGIP 303
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 501085031 380 PEQRKHLFQPFVrgdsarST----SGTGLGLAIVQRIVDNHNGMLEIGSSERGGLSIRAWLPI 438
Cdd:COG4191 304 PEVLERIFEPFF------TTkpvgKGTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITLPL 360
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
237-439 |
2.13e-32 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 126.11 E-value: 2.13e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 237 LMAGVSHDLRTPLTRIRLATEMMGEE--DGYLAESINKDIEEC---NAIIEQFIDYLRtGQEMPMEMADLNAVLGEVIA- 310
Cdd:COG3852 138 LAAGLAHEIRNPLTGIRGAAQLLERElpDDELREYTQLIIEEAdrlNNLVDRLLSFSR-PRPPEREPVNLHEVLERVLEl 216
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 311 AESGYER--EIDTALQPGSIQVKMHPLSIKRAIANMVVNAARY--GNGWIKVSSGTEP--------HRAW--FQVEDDGP 376
Cdd:COG3852 217 LRAEAPKniRIVRDYDPSLPEVLGDPDQLIQVLLNLVRNAAEAmpEGGTITIRTRVERqvtlgglrPRLYvrIEVIDNGP 296
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 501085031 377 GIKPEQRKHLFQPFVrgdsarST--SGTGLGLAIVQRIVDNHNGMLEIGSSERGGLSIRAWLPIP 439
Cdd:COG3852 297 GIPEEILDRIFEPFF------TTkeKGTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYLPLE 355
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
337-439 |
2.16e-31 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 116.21 E-value: 2.16e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 337 IKRAIANMVVNAARYG--NGWIKVSSGTEPHRAWFQVEDDGPGIKPEQRKHLFQPFVRGD-SARSTSGTGLGLAIVQRIV 413
Cdd:smart00387 6 LRQVLSNLLDNAIKYTpeGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDkRSRKIGGTGLGLSIVKKLV 85
|
90 100
....*....|....*....|....*.
gi 501085031 414 DNHNGMLEIGSSERGGLSIRAWLPIP 439
Cdd:smart00387 86 ELHGGEISVESEPGGGTTFTITLPLE 111
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
241-438 |
1.64e-29 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 120.66 E-value: 1.64e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 241 VSHDLRTPLTRIRLATEMMGEEDG---------YLaESINKDIEECNAIIEQFIDYLRTG-QEMPMEMADLNAVLGEVIA 310
Cdd:COG4251 289 ASHDLREPLRKISGFSQLLEEDYGdkldeegreYL-ERIRDAAERMQALIDDLLAYSRVGrQELEFEPVDLNELLEEVLE 367
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 311 ------AESGYEREIDTALQpgsiqVKMHPLSIKRAIANMVVNAARYG----NGWIKVSSGTEPHRAWFQVEDDGPGIKP 380
Cdd:COG4251 368 dlepriEERGAEIEVGPLPT-----VRGDPTLLRQVFQNLISNAIKYSrpgePPRIEIGAEREGGEWVFSVRDNGIGIDP 442
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 501085031 381 EQRKHLFQPFVRGDSARSTSGTGLGLAIVQRIVDNHNGMLEIGSSERGGLSIRAWLPI 438
Cdd:COG4251 443 EYAEKIFEIFQRLHSRDEYEGTGIGLAIVKKIVERHGGRIWVESEPGEGATFYFTLPK 500
|
|
| phoR_proteo |
TIGR02966 |
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory ... |
213-428 |
4.71e-28 |
|
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems]
Pssm-ID: 274368 [Multi-domain] Cd Length: 333 Bit Score: 113.46 E-value: 4.71e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 213 VRSVTRafnhmaagVKQLADDRTLLMAGVSHDLRTPLTRIRLATEMMGEEDGYLAESINKDIEECN-------AIIEQFI 285
Cdd:TIGR02966 101 ARDVTR--------LRRLEQMRRDFVANVSHELRTPLTVLRGYLETLADGPDEDPEEWNRALEIMLeqsqrmqSLVEDLL 172
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 286 DYLR---TGQEMPMEMADLNAVLGEV---IAAESGYER-EIDTALQPGsIQVKMHPLSIKRAIANMVVNAARYG--NGWI 356
Cdd:TIGR02966 173 TLSRlesAASPLEDEPVDMPALLDHLrdeAEALSQGKNhQITFEIDGG-VDVLGDEDELRSAFSNLVSNAIKYTpeGGTI 251
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 501085031 357 KVSSGTEPHRAWFQVEDDGPGIKPEQRKHLFQPFVRGDSARS--TSGTGLGLAIVQRIVDNHNGMLEIgSSERG 428
Cdd:TIGR02966 252 TVRWRRDGGGAEFSVTDTGIGIAPEHLPRLTERFYRVDKSRSrdTGGTGLGLAIVKHVLSRHHARLEI-ESELG 324
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
337-437 |
8.83e-28 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 106.26 E-value: 8.83e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 337 IKRAIANMVVNAARYGNGWIKVSSGTEpHRAW-FQVEDDGPGIKPEQRKHLFQPFVRGDSARS--TSGTGLGLAIVQRIV 413
Cdd:cd16949 1 LARALENVLRNALRYSPSKILLDISQD-GDQWtITITDDGPGVPEDQLEQIFLPFYRVDSARDreSGGTGLGLAIAERAI 79
|
90 100
....*....|....*....|....
gi 501085031 414 DNHNGMLEIGSSERGGLSIRAWLP 437
Cdd:cd16949 80 EQHGGKIKASNRKPGGLRVRIWLP 103
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
334-439 |
3.71e-27 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 104.76 E-value: 3.71e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 334 PLSIKRAIANMVVNAARY----GNGWIKVSSGtepHRAWFQVEDDGPGIKPEQRKHLFQPFVRGDSaRSTSGTGLGLAIV 409
Cdd:pfam02518 3 ELRLRQVLSNLLDNALKHaakaGEITVTLSEG---GELTLTVEDNGIGIPPEDLPRIFEPFSTADK-RGGGGTGLGLSIV 78
|
90 100 110
....*....|....*....|....*....|
gi 501085031 410 QRIVDNHNGMLEIGSSERGGLSIRAWLPIP 439
Cdd:pfam02518 79 RKLVELLGGTITVESEPGGGTTVTLTLPLA 108
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
339-437 |
1.13e-26 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 103.28 E-value: 1.13e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 339 RAIANMVVNAARYGNGWIKVSSGTEPHRAWFQVEDDGPGIKPEQRKHLFQPFVRGDSA--RSTSGTGLGLAIVQRIVDNH 416
Cdd:cd16939 3 RALDNLLRNALRYAHRTVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRLDPSrdRATGGFGLGLAIVHRVALWH 82
|
90 100
....*....|....*....|.
gi 501085031 417 NGMLEIGSSERGGLSIRAWLP 437
Cdd:cd16939 83 GGHVECDDSELGGACFRLTWP 103
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
161-439 |
1.74e-26 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 111.33 E-value: 1.74e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 161 FRYTL-AIMLLAIGG----AWLFIRIQNRPLVDLEHAALQVGKGMIPPPLREYGAS-EVRSVTRAFNHMAA----GVKQL 230
Cdd:TIGR01386 162 LRKWLiLIAVLLVLLtallGWWITRLGLEPLRRLSAVAARISPESLDQRLDPSRAPaELRELAQSFNAMLGrledAFQRL 241
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 231 ADdrtlLMAGVSHDLRTPLTRIRLATEmmgeedgyLAESINKDIEECNAIIEQFIDYLRTGQEMPMEM------------ 298
Cdd:TIGR01386 242 SQ----FSADLAHELRTPLTNLLGQTQ--------VALSQPRTGEEYREVLESNLEELERLSRMVSDMlflaradngqla 309
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 299 ---------ADLNAVLG--EVIAAESGYEREIDtalqpGSIQVKMHPLSIKRAIANMVVNAARYG--NGWIKVSSGTEPH 365
Cdd:TIGR01386 310 lervrldlaAELAKVAEyfEPLAEERGVRIRVE-----GEGLVRGDPQMFRRAISNLLSNALRHTpdGGTITVRIERRSD 384
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 501085031 366 RAWFQVEDDGPGIKPEQRKHLFQPFVRGDSAR--STSGTGLGLAIVQRIVDNHNGMLEIGSSERgglSIRAWLPIP 439
Cdd:TIGR01386 385 EVRVSVSNPGPGIPPEHLSRLFDRFYRVDPARsnSGEGTGLGLAIVRSIMEAHGGRASAESPDG---KTRFILRFP 457
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
204-437 |
1.69e-25 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 106.98 E-value: 1.69e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 204 PLREYGAS-EVRSVTRAFNHMAAGVKQLADDRTLLMAGVSHDLRTPLTRIRLATEMMGEEDGYLAESINKDIEECNAIIE 282
Cdd:PRK10755 106 PIAIHSSTlEIEAVTSALNQLVSRLTSTLDQERLFTADVAHELRTPLAGIRLHLELLEKQHHIDVAPLIARLDQMMHTVE 185
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 283 QFIDYLRTGQEMPMEMADLNAVLGEVIAAEsgyEREIDTALQ-----------PGSIQVKMHPLSIKRAIANMVVNAARY 351
Cdd:PRK10755 186 QLLQLARAGQSFSSGHYQTVKLLEDVILPS---QDELSEMLEqrqqtlllpesAADITVQGDATLLRLLLRNLVENAHRY 262
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 352 G--NGWIKVSSGTEPHRAWFQVEDDGPGIKPEQRKHLFQPFVRGDSarSTSGTGLGLAIVQRIVDNHNGMLEI-GSSERG 428
Cdd:PRK10755 263 SpeGSTITIKLSQEDGGAVLAVEDEGPGIDESKCGELSKAFVRMDS--RYGGIGLGLSIVSRITQLHHGQFFLqNRQERS 340
|
....*....
gi 501085031 429 GLSIRAWLP 437
Cdd:PRK10755 341 GTRAWVWLP 349
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
237-438 |
3.98e-25 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 108.13 E-value: 3.98e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 237 LMAGVSHDLRTPLTRIRLATEMMGEEDG------YLAEsINKDIEECNAIIEQFIDYLRTgQEMPMEMADLNAVLGEVI- 309
Cdd:PRK11360 393 LVAGVAHEIRNPLTAIRGYVQIWRQQTSdppsqeYLSV-VLREVDRLNKVIDQLLEFSRP-RESQWQPVSLNALVEEVLq 470
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 310 -AAESGYEREID--TALQPGSIQVKMHPLSIKRAIANMVVNA--ARYGNGWIKVSSGTEPH-RAWFQVEDDGPGIKPEQR 383
Cdd:PRK11360 471 lFQTAGVQARVDfeTELDNELPPIWADPELLKQVLLNILINAvqAISARGKIRIRTWQYSDgQVAVSIEDNGCGIDPELL 550
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 501085031 384 KHLFQPFVrgdSARSTsGTGLGLAIVQRIVDNHNGMLEIGSSERGGLSIRAWLPI 438
Cdd:PRK11360 551 KKIFDPFF---TTKAK-GTGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLPI 601
|
|
| MtrAB_MtrB |
NF040691 |
MtrAB system histidine kinase MtrB; |
165-445 |
2.39e-24 |
|
MtrAB system histidine kinase MtrB;
Pssm-ID: 468655 [Multi-domain] Cd Length: 507 Bit Score: 105.49 E-value: 2.39e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 165 LAIMLLAIGGAWLFIRIQNRPLVDLEHAALQVGKGMIPPPLREYGASEVRSVTRAFNHMAAGVK----QLADDRTL---L 237
Cdd:NF040691 195 LALVVLLGLIAWLVTRQVVAPVRSAARTAERFAAGDLSERMPVKGEDDLARLARSFNQMADSLQrqirQLEELSRLqqrF 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 238 MAGVSHDLRTPLTRIRLATEMMGEEDGYLAESINKDIEECNAIIEQF---------IDYLRTGQ-EMPMEMADLNAVLGE 307
Cdd:NF040691 275 VSDVSHELRTPLTTIRMAADVIHDSRDDFDPATARSAELLHTELDRFesllsdlleISRFDAGAaELDVEPVDLRPLVRR 354
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 308 V------IAAESGYEREIDTALQPgsIQVKMHPLSIKRAIANMVVNAARYGNGW-IKVSSGTEPHRAWFQVEDDGPGIKP 380
Cdd:NF040691 355 VvdalrqLAERAGVELRVDAPGTP--VVAEVDPRRVERVLRNLVVNAIEHGEGKpVVVTVAQDDTAVAVTVRDHGVGLKP 432
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 501085031 381 EQRKHLFQPFVRGDSARS--TSGTGLGLAIVQRIVDNHNGMLEIGSSERGGLSIRAWLPipvaRVPG 445
Cdd:NF040691 433 GEVALVFDRFWRADPARArtTGGTGLGLAIALEDARLHGGWLEAWGRPGQGSQFRLTLP----RVAG 495
|
|
| KinC |
COG5807 |
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome ... |
237-438 |
2.77e-24 |
|
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444509 [Multi-domain] Cd Length: 358 Bit Score: 103.33 E-value: 2.77e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 237 LMAGVSHDLRTPLTRIRLATEMMGEEDGY-----LAESINKDIEECNAIIEQFIDYLRTgQEMPMEMADLNAVLGEVIA- 310
Cdd:COG5807 150 LAAGIAHEIRNPLTSIKGFLQLLQESREDsereeYFNIIISEIDRINTIITELLVLSKP-KKFNFKKLNLNDVLEDVIAl 228
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 311 ----AESgYEREIDTALQPGSIQVKMHPLSIKRAIANMVVNA--ARYGNGWIKVSSGTEPHRAWFQVEDDGPGIKPEQRK 384
Cdd:COG5807 229 lsteAIL-KNISIKYDLADDEPVINGDKNQLKQVFINLIKNAieAMETGGNITIKTYVEGDFVVISVKDEGIGIPEEVLE 307
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 501085031 385 HLFQPFVrgdsarST--SGTGLGLAIVQRIVDNHNGMLEIGSSERGGLSIRAWLPI 438
Cdd:COG5807 308 KIGEPFF------TTkeEGTGLGLSICKKIIEEHNGTIEVESKPGKGTTFTIYLPL 357
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
165-439 |
4.12e-23 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 101.46 E-value: 4.12e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 165 LAIMLLAIGGA---WLfiriqNRPLVDLEHAALQVGKGmIPPPLREYGASEVRSVTRAFNHMaagVKQLADD-------R 234
Cdd:PRK11100 191 LLGIALLIGAGvvwWL-----NRSIRRLTRYADAVTEG-KPVPLPKLGSSELRELAQALESM---RVKLEGKayveqyvQ 261
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 235 TLlmagvSHDLRTPLTRIRLATEM----MGEEDgylAESINKDIEECNAIIEQFIDYL--------RTGQEmPMEMADLN 302
Cdd:PRK11100 262 TL-----THELKSPLAAIRGAAELlqedPPPED---RARFTGNILTQSARLQQLIDRLlelarleqRQELE-VLEPVALA 332
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 303 AVLGEVIAA-ESGYE-REIDTALQPGSIQVKMHPLSIKRAIANMVVNAARYG--NGWIKVSSGTEPHRAWFQVEDDGPGI 378
Cdd:PRK11100 333 ALLEELVEArEAQAAaKGITLRLRPDDARVLGDPFLLRQALGNLLDNAIDFSpeGGTITLSAEVDGEQVALSVEDQGPGI 412
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 501085031 379 kPE-QRKHLFQPF---VRGDSARStsGTGLGLAIVQRIVDNHNGMLEIGSSERGGLSIRAWLPIP 439
Cdd:PRK11100 413 -PDyALPRIFERFyslPRPANGRK--STGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTLPRH 474
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
213-428 |
2.40e-22 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 98.54 E-value: 2.40e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 213 VRSVTRafnhmaagVKQLADDRTLLMAGVSHDLRTPLTRIRLATEMMGEED--GYLAESINKDIEE----CNAIIEQFID 286
Cdd:PRK11006 191 ARDVTQ--------MHQLEGARRNFFANVSHELRTPLTVLQGYLEMMQDQPleGALREKALHTMREqtqrMEGLVKQLLT 262
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 287 YLRtgqempMEMA---DLNAVLgEVIAAESGYEREIDTALQ---------PGSIQVKMHPLSIKRAIANMVVNAARY--G 352
Cdd:PRK11006 263 LSK------IEAAptiDLNEKV-DVPMMLRVLEREAQTLSQgkhtitfevDNSLKVFGNEDQLRSAISNLVYNAVNHtpE 335
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 501085031 353 NGWIKVSSGTEPHRAWFQVEDDGPGIKPEQRKHLFQPFVRGDSARS--TSGTGLGLAIVQRIVDNHNGMLEIgSSERG 428
Cdd:PRK11006 336 GTHITVRWQRVPQGAEFSVEDNGPGIAPEHIPRLTERFYRVDKARSrqTGGSGLGLAIVKHALSHHDSRLEI-ESEVG 412
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
237-438 |
1.14e-21 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 97.35 E-value: 1.14e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 237 LMAGVSHDLRTPLTRIR-----LATEMMGEEDGYLaESINKDIEECNAIIEQFIDYLRTgQEMPMEMADLNAVLGEVIA- 310
Cdd:COG5809 273 LAAGIAHEIRNPLTSLKgfiqlLKDTIDEEQKTYL-DIMLSELDRIESIISEFLVLAKP-QAIKYEPKDLNTLIEEVIPl 350
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 311 --AESGYER-EIDTALQPGSIQVKMHPLSIKRAIANMVVNA--ARYGNGWIKVSSG-TEPHRAWFQVEDDGPGIKPEQRK 384
Cdd:COG5809 351 lqPQALLKNvQIELELEDDIPDILGDENQLKQVFINLLKNAieAMPEGGNITIETKaEDDDKVVISVTDEGCGIPEERLK 430
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 501085031 385 HLFQPFvrgdSARSTSGTGLGLAIVQRIVDNHNGMLEIGSSERGGLSIRAWLPI 438
Cdd:COG5809 431 KLGEPF----YTTKEKGTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITLPI 480
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
327-436 |
1.14e-21 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 89.77 E-value: 1.14e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 327 SIQVKMHPLSIKRAIANMVVNAARY----GNGWIKVSSGTEphrAWFQVEDDGPGIKPEQRKHLFQPFVRGDSaRSTSGT 402
Cdd:cd16940 4 DIQVQGDALLLFLLLRNLVDNAVRYspqgSRVEIKLSADDG---AVIRVEDNGPGIDEEELEALFERFYRSDG-QNYGGS 79
|
90 100 110
....*....|....*....|....*....|....
gi 501085031 403 GLGLAIVQRIVDNHNGMLEIGSSERGGLSIRAWL 436
Cdd:cd16940 80 GLGLSIVKRIVELHGGQIFLGNAQGGGLEAWVRL 113
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
337-437 |
1.11e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 84.05 E-value: 1.11e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 337 IKRAIANMVVNAARYGN--GWIKVSSGTEPHRAWFQVEDDGPGIKPEQRKHLFQPFVRGDSA--RSTSGTGLGLAIVQRI 412
Cdd:cd16946 5 LQQLFVNLLENSLRYTDtgGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSrnRASGGSGLGLAICHNI 84
|
90 100
....*....|....*....|....*
gi 501085031 413 VDNHNGMLEIGSSERGGLSIRAWLP 437
Cdd:cd16946 85 ALAHGGTISAEHSPLGGLRLVLTLP 109
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
220-438 |
5.51e-18 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 85.84 E-value: 5.51e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 220 FNHMAAGVKQLADDRTLLMAGVSHDLRTPLTRIRLATEMMgeEDG---YLAESINKDIEECnAIIEQFIDYLRTgqempM 296
Cdd:PRK10549 226 FNQLASTLEKNEQMRRDFMADISHELRTPLAVLRGELEAI--QDGvrkFTPESVASLQAEV-GTLTKLVDDLHQ-----L 297
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 297 EMADLNAV-----------LGEVIAAeSGYER------EIDTALqPGSIQVKMHPLSIKRAIANMVVNAARYGN--GWIK 357
Cdd:PRK10549 298 SLSDEGALayrktpvdlvpLLEVAGG-AFRERfasrglTLQLSL-PDSATVFGDPDRLMQLFNNLLENSLRYTDsgGSLH 375
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 358 VSSGTEPHRAWFQVEDDGPGIKPEQRKHLFQPFVRGDSAR--STSGTGLGLAIVQRIVDNHNGMLEIGSSERGGLSIRAW 435
Cdd:PRK10549 376 ISAEQRDKTLRLTFADSAPGVSDEQLQKLFERFYRTEGSRnrASGGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVE 455
|
...
gi 501085031 436 LPI 438
Cdd:PRK10549 456 LPL 458
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
223-439 |
6.92e-18 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 86.63 E-value: 6.92e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 223 MAAGVKQLaddRTLLMAGVSHDLRTPLTRIRLATEMMGEEdgyLAESINKDIEECNAIIEQFIDYLRTGQEMpMEMADLN 302
Cdd:PRK10490 656 LASEREQL---RNALLAALSHDLRTPLTVLFGQAEILTLD---LASEGSPHARQASEIRQQVLNTTRLVNNL-LDMARIQ 728
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 303 A----------VLGEVIAAESgyeREIDTALQPGSIQVKM-------H---PLsIKRAIANMVVNAARY-GNGW-IKVSS 360
Cdd:PRK10490 729 SggfnlrkewlTLEEVVGSAL---QMLEPGLSGHPINLSLpepltliHvdgPL-FERVLINLLENAVKYaGAQAeIGIDA 804
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 501085031 361 GTEPHRAWFQVEDDGPGIKPEQRKHLFQPFVRGDSARSTSGTGLGLAIVQRIVDNHNGMLEIGSSERGGLSIRAWLPIP 439
Cdd:PRK10490 805 HVEGERLQLDVWDNGPGIPPGQEQLIFDKFARGNKESAIPGVGLGLAICRAIVEVHGGTIWAENRPEGGACFRVTLPLE 883
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
337-424 |
1.47e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 78.01 E-value: 1.47e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 337 IKRAIANMVVNAARYG--NGWIKVSSGTEPHRAWFQVEDDGPGIKPEQRKHLFQPFVRGDSARS--TSGTGLGLAIVQRI 412
Cdd:cd16952 1 LRSAFSNLVSNAVKYTppSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCrnTGGTGLGLAIVKHV 80
|
90
....*....|..
gi 501085031 413 VDNHNGMLEIGS 424
Cdd:cd16952 81 MSRHDARLLIAS 92
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
274-438 |
1.96e-17 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 83.74 E-value: 1.96e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 274 IEECNAIIEQFIDYLRTGQEMPMemadLNAVLGEVI--AAESGYEREIDTALQPGSIQVKMHPLSikRAIANMVVNA--- 348
Cdd:COG3290 223 IDEISEELQELIDSLLSRIGNPV----LAALLLGKAarARERGIDLTIDIDSDLPDLPLSDTDLV--TILGNLLDNAiea 296
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 349 ---ARYGNGWIKVSSGTEPHRAWFQVEDDGPGIKPEQRKHLFQpfvRGDSARSTSGTGLGLAIVQRIVDNHNGMLEIGSS 425
Cdd:COG3290 297 vekLPEEERRVELSIRDDGDELVIEVEDSGPGIPEELLEKIFE---RGFSTKLGEGRGLGLALVKQIVEKYGGTIEVESE 373
|
170
....*....|...
gi 501085031 426 ERGGLSIRAWLPI 438
Cdd:COG3290 374 EGEGTVFTVRLPK 386
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
369-440 |
2.23e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 77.53 E-value: 2.23e-17
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 501085031 369 FQVEDDGPGIKPEQRKHLFQPFVRGDSA--RSTSGTGLGLAIVQRIVDNHNGmlEIGSSERGGLSIRAWLPIPV 440
Cdd:cd16922 39 FSVEDTGIGIPEEQQARLFEPFSQADSSttRKYGGTGLGLAISKKLVELMGG--DISVESEPGQGSTFTFTLPL 110
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
343-433 |
2.46e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 78.06 E-value: 2.46e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 343 NMVVNAARYGNGWIKVSSGTEPHRAWFQVEDDGPGIKPEQRKHLFQPFVRGDSarSTSGTGLGLAIVQRIVDNHNGMLEI 422
Cdd:cd16954 44 NLLDNACKWCLEFVEVTARQTDGGLHLIVDDDGPGVPESQRSKIFQRGQRLDE--QRPGQGLGLAIAKEIVEQYGGELSL 121
|
90
....*....|.
gi 501085031 423 GSSERGGLSIR 433
Cdd:cd16954 122 SDSPLGGARFE 132
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
334-438 |
3.90e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 76.69 E-value: 3.90e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 334 PLSIKRAIANMVVNAARY--GNGWIKVSSGTEPHRAWFQVEDDGPGIKPEQRKHLFQPFVrgDSARSTSGTGLGLAIVQR 411
Cdd:cd16943 1 PSQLNQVLLNLLVNAAQAmeGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFF--TTKPVGEGTGLGLSLSYR 78
|
90 100
....*....|....*....|....*..
gi 501085031 412 IVDNHNGMLEIGSSERGGLSIRAWLPI 438
Cdd:cd16943 79 IIQKHGGTIRVASVPGGGTRFTIILPI 105
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
234-444 |
5.25e-17 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 83.80 E-value: 5.25e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 234 RTLLMAGVSHDLRTPLTRIRLATEMMGEED------GYLaESINKDIEECNAIIEQFIDY--LRTG------QEMPMEMA 299
Cdd:PRK11466 444 KSAFLAAMSHEIRTPLYGILGTAQLLADNPalnaqrDDL-RAITDSGESLLTILNDILDYsaIEAGgknvsvSDEPFEPR 522
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 300 DL---------NAVLGEVIAAESGYEREIDTALQPgsiqvkmHPLSIKRAIANMVVNAARYGN-GWIKVSSGTEPHRAWF 369
Cdd:PRK11466 523 PLlestlqlmsGRVKGRPIRLATDIADDLPTALMG-------DPRRIRQVITNLLSNALRFTDeGSIVLRSRTDGEQWLV 595
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 501085031 370 QVEDDGPGIKPEQRKHLFQPFVRGDSARstSGTGLGLAIVQRIVDNHNGMLEIGSSERGGLSIRAWLPIPVARVP 444
Cdd:PRK11466 596 EVEDSGCGIDPAKLAEIFQPFVQVSGKR--GGTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLRLPLRVATAP 668
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
237-442 |
1.70e-16 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 81.37 E-value: 1.70e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 237 LMAGVSHDLRTPLTRIR-LATEM-----MGEEDGYLAESINKDIEECNAIIEQFIDYLRTGqEMPMEMADLNAVLGEVIA 310
Cdd:PRK10364 240 LAAGVAHEIRNPLSSIKgLAKYFaerapAGGEAHQLAQVMAKEADRLNRVVSELLELVKPT-HLALQAVDLNDLINHSLQ 318
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 311 AESGYEREIDTALQ----PGSIQVKMHPLSIKRAIANMVVNA--ARYGNGWIKVSSGTEPHRAWFQVEDDGPGIKPEQRK 384
Cdd:PRK10364 319 LVSQDANSREIQLRftanDTLPEIQADPDRLTQVLLNLYLNAiqAIGQHGVISVTASESGAGVKISVTDSGKGIAADQLE 398
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 501085031 385 HLFQPFVrgdsARSTSGTGLGLAIVQRIVDNHNGMLEIGSSERGGLSIRAWLPIPVAR 442
Cdd:PRK10364 399 AIFTPYF----TTKAEGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLPVNITR 452
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
237-439 |
1.86e-16 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 81.32 E-value: 1.86e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 237 LMAGVSHDLRTPLTRIRLATEMMG---EEDGYLAESINKDIEECNAIIEQFIdYLRTGQEMPMEMADLNAVLGEVIaaes 313
Cdd:COG5805 290 LAAGIAHEIRNPLTSIKGFLQLLQpgiEDKEEYFDIMLSELDRIESIISEFL-ALAKPQAVNKEKENINELIQDVV---- 364
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 314 gyereidTALQP----GSIQVKMHPLS-----------IKRAIANMVVNA--ARYGNGWIKVSSGTEPHRAWFQVEDDGP 376
Cdd:COG5805 365 -------TLLETeailHNIQIRLELLDedpfiycdenqIKQVFINLIKNAieAMPNGGTITIHTEEEDNSVIIRVIDEGI 437
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 501085031 377 GIKPEQRKHLFQPFVrgdsarST--SGTGLGLAIVQRIVDNHNGMLEIGSSERGGLSIRAWLPIP 439
Cdd:COG5805 438 GIPEERLKKLGEPFF------TTkeKGTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITLPLS 496
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
337-437 |
4.70e-15 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 70.98 E-value: 4.70e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 337 IKRAIANMVVNAARY--GNGWIKVS-SGTEPHRAWFQVEDDGPGIKPEQRKHLFQPF--VRGDSARSTSGTGLGLAIVQR 411
Cdd:cd16925 5 YERVVLNLLSNAFKFtpDGGRIRCIlEKFRLNRFLLTVSDSGPGIPPNLREEIFERFrqGDGSSTRAHGGTGLGLSIVKE 84
|
90 100
....*....|....*....|....*.
gi 501085031 412 IVDNHNGMLEIGSSERGGLSIRAWLP 437
Cdd:cd16925 85 FVELHGGTVTVSDAPGGGALFQVELP 110
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
164-430 |
3.41e-14 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 74.30 E-value: 3.41e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 164 TLAIMLLAIggAWLFIRiQNRPLVDLEhAALQVGKGMIPPPLREYGA-SEVRSVTRAFNHMAAGVKQLADDRTLLMAGVS 242
Cdd:PRK10337 170 ALPIMLIIL--MVLLGR-ELAPLKKLA-LALRMRDPDSETPLNATGVpSEVRPLVEALNQLFARTHAMMVRERRFTSDAA 245
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 243 HDLRTPLTRIRLATEM--MGEEDGYLAE----SINKDIEECNAIIEQF-----IDYLRTGQEM-PMEMADL--NAVLGEV 308
Cdd:PRK10337 246 HELRSPLAALKVQTEVaqLSDDDPQARKkallQLHAGIDRATRLVDQLltlsrLDSLDNLQDVaEIPLEDLlqSAVMDIY 325
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 309 IAAESGyerEIDTALQPGSIQVKM--HPLSIKRAIANMVVNAARYGNGWIKVSSGTEPHRawFQVEDDGPGIKPEQRKHL 386
Cdd:PRK10337 326 HTAQQA---GIDVRLTLNAHPVIRtgQPLLLSLLVRNLLDNAIRYSPQGSVVDVTLNARN--FTVRDNGPGVTPEALARI 400
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 501085031 387 FQPFVR--GDSArstSGTGLGLAIVQRIVDNHNGMLEIGSSERGGL 430
Cdd:PRK10337 401 GERFYRppGQEA---TGSGLGLSIVRRIAKLHGMNVSFGNAPEGGF 443
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
337-435 |
3.62e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 68.26 E-value: 3.62e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 337 IKRAIANMVVNAARYG--NGWIKVSSGTEPHRAWFQVEDDGPGIKPEQRKHLFQPFVRGDSARSTSG-TGLGLAIVQRIV 413
Cdd:cd16975 5 LSRALINIISNACQYApeGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSRRSGGhYGMGLYIAKNLV 84
|
90 100
....*....|....*....|..
gi 501085031 414 DNHNGMLEIGSSERGGLSIRAW 435
Cdd:cd16975 85 EKHGGSLIIENSQKGGAEVTVK 106
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
337-437 |
4.76e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 67.95 E-value: 4.76e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 337 IKRAIANMVVNAARY--------GNGWIKVSSGTEPhRAWFQVEDDGPGIKPEQRKHLFQPFVRGDSArstsGTGLGLAI 408
Cdd:cd16944 5 ISQVLTNILKNAAEAiegrpsdvGEVRIRVEADQDG-RIVLIVCDNGKGFPREMRHRATEPYVTTRPK----GTGLGLAI 79
|
90 100
....*....|....*....|....*....
gi 501085031 409 VQRIVDNHNGMLEIGSSERGGLSIRAWLP 437
Cdd:cd16944 80 VKKIMEEHGGRISLSNREAGGACIRIILP 108
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
212-428 |
4.82e-14 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 74.04 E-value: 4.82e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 212 EVRSVTRAFNHMAAGVKQLADDRTLLMAGVSHDLRTPLTRIRLATEMMGEED---GYLAESINKDIEECNAIIEQFIDYL 288
Cdd:PRK09835 240 ELEQLVLSFNHMIERIEDVFTRQSNFSADIAHEIRTPITNLITQTEIALSQSrsqKELEDVLYSNLEELTRMAKMVSDML 319
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 289 RTGQE------MPMEMADLNAVLGEVIA-----AEsgyEREIDTALQPGSIQVKMHPLSIKRAIANMVVNAARY---GNG 354
Cdd:PRK09835 320 FLAQAdnnqliPEKKMLDLADEVGKVFDffeawAE---ERGVELRFVGDPCQVAGDPLMLRRAISNLLSNALRYtpaGEA 396
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 501085031 355 wIKVSSGTEPHRAWFQVEDDGPGIKPEQRKHLFQPFVRGDSARSTSG--TGLGLAIVQRIVDNHNGMLEIGSSERG 428
Cdd:PRK09835 397 -ITVRCQEVDHQVQLVVENPGTPIAPEHLPRLFDRFYRVDPSRQRKGegSGIGLAIVKSIVVAHKGTVAVTSDARG 471
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
341-437 |
5.57e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 67.70 E-value: 5.57e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 341 IANMVVNA------ARYGNGWIKVSSGTEPHRAWFQVEDDGPGIKPEQRKHLFQpfvRGDSARSTSGTGLGLAIVQRIVD 414
Cdd:cd16915 5 VGNLIDNAldalaaTGAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFE---RGVSTKGQGERGIGLALVRQSVE 81
|
90 100
....*....|....*....|...
gi 501085031 415 NHNGMLEIGSSERGGLSIRAWLP 437
Cdd:cd16915 82 RLGGSITVESEPGGGTTFSIRIP 104
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
236-438 |
1.77e-13 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 71.27 E-value: 1.77e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 236 LLMAGVSHDLRTPLTRIRLATEMMGEE--DGYLAESINkdieecnAIIEQfIDYLRT------GQEMPME--MADLNAVL 305
Cdd:PRK11073 132 DLVRGLAHEIKNPLGGLRGAAQLLSKAlpDPALTEYTK-------VIIEQ-ADRLRNlvdrllGPQRPGThvTESIHKVA 203
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 306 GEV---IAAESGY----EREIDTALQpgsiQVKMHPLSIKRAIANMVVNAAR---YGNGWIKVSSGT--------EPHR- 366
Cdd:PRK11073 204 ERVvqlVSLELPDnvrlIRDYDPSLP----ELAHDPDQIEQVLLNIVRNALQalgPEGGTITLRTRTafqltlhgERYRl 279
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 501085031 367 -AWFQVEDDGPGIKPEQRKHLFQPFVrgdSARStSGTGLGLAIVQRIVDNHNGMLEIgSSERGGLSIRAWLPI 438
Cdd:PRK11073 280 aARIDIEDNGPGIPPHLQDTLFYPMV---SGRE-GGTGLGLSIARNLIDQHSGKIEF-TSWPGHTEFSVYLPI 347
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
164-438 |
3.28e-13 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 71.20 E-value: 3.28e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 164 TLAIMLLAIGGAWLFIRIQNRPLVDLEHAALQVGKGMIPPpLREYGASEVRSVTRAFNHMAAGVKQLADDRTLLMAGVS- 242
Cdd:COG2972 163 ILLLLLLALLLSYLLSRSITRPIKRLKKAMKKVEKGDLVR-LEVSGNDEIGILARSFNEMVERIKELIEEVYELELEKKe 241
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 243 ------------HDLRTPLTRIRlatemmgeedgYLAESinKDIEECNAIIEQFIDYLRTGQEMPMEMADLNAvlgEVIA 310
Cdd:COG2972 242 aelkalqaqinpHFLFNTLNSIR-----------WLAEL--EDPEEAEEMLEALSKLLRYSLSKGDELVTLEE---ELEL 305
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 311 AES-------------GYEREIDTALQ-----PGSIQvkmhPL---SIKRAIANMVvnaaryGNGWIKVSSGTEPHRAWF 369
Cdd:COG2972 306 IKSyleiqklrfgdrlEVEIEIDEELLdllipKLILQ----PLvenAIEHGIEPKE------GGGTIRISIRKEGDRLVI 375
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 501085031 370 QVEDDGPGIKPEQRKHLFQPFvrgdsARSTSGTGLGLAIVQRIVDNHNGM---LEIGSSERGGLSIRAWLPI 438
Cdd:COG2972 376 TVEDNGVGMPEEKLEKLLEEL-----SSKGEGRGIGLRNVRERLKLYYGEeygLEIESEPGEGTTVTIRIPL 442
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
233-418 |
4.81e-13 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 70.37 E-value: 4.81e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 233 DRTLLMagVSHDLRTPLTRIRLATEMMgeEDGYlaesINKDIEECNAIIEQFIDYLRTG-QEM----------------- 294
Cdd:PRK09303 152 DRVLAM--LAHDLRTPLTAASLALETL--ELGQ----IDEDTELKPALIEQLQDQARRQlEEIerlitdllevgrtrwea 223
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 295 ----PMEMaDLNAVLGEVIAaesgyerEIDTALQPGSIQVKMH-----------PLSIKRAIANMVVNAARY--GNGWIK 357
Cdd:PRK09303 224 lrfnPQKL-DLGSLCQEVIL-------ELEKRWLAKSLEIQTDipsdlpsvyadQERIRQVLLNLLDNAIKYtpEGGTIT 295
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 501085031 358 VSSgtePHRA--WFQVE--DDGPGIKPEQRKHLFQPFVRGDSARSTSGTGLGLAIVQRIVDNHNG 418
Cdd:PRK09303 296 LSM---LHRTtqKVQVSicDTGPGIPEEEQERIFEDRVRLPRDEGTEGYGIGLSVCRRIVRVHYG 357
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
339-430 |
7.95e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 64.33 E-value: 7.95e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 339 RAIANMVVNAARYG--NGWIKVSSGTEPHRAWFQVEDDGPGIKPEQRKHLFQPFVRGDSARSTSGTGLGLAIVQRIVDNH 416
Cdd:cd16923 3 RVFSNLLSNAIKYSpeNTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDNSRNTEGAGLGLSIAKAIIELH 82
|
90
....*....|....
gi 501085031 417 NGMLEIGSSERGGL 430
Cdd:cd16923 83 GGSASAEYDDNHDL 96
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
337-425 |
1.66e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 63.57 E-value: 1.66e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 337 IKRAIANMVVNAAR---YGNGWIKVSSGTE--------PHRAWFQVE--DDGPGIKPEQRKHLFQPFVRGdsarSTSGTG 403
Cdd:cd16918 1 LIQVFLNLVRNAAQalaGSGGEIILRTRTQrqvtlghpRHRLALRVSviDNGPGIPPDLQDTIFYPMVSG----RENGTG 76
|
90 100
....*....|....*....|..
gi 501085031 404 LGLAIVQRIVDNHNGMLEIGSS 425
Cdd:cd16918 77 LGLAIAQNIVSQHGGVIECDSQ 98
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
280-450 |
4.08e-12 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 68.55 E-value: 4.08e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 280 IIEQFIDYLRTgQEMPMEMADLNAVLGEVIA---AESGYEREIDTALQPGSIQVKMHPLSIKRAIANMVVNAARY--GNG 354
Cdd:PRK13837 502 IIDQILAFGRK-GERNTKPFDLSELVTEIAPllrVSLPPGVELDFDQDQEPAVVEGNPAELQQVLMNLCSNAAQAmdGAG 580
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 355 WIKV-------------SSGTEPHRAWFQ--VEDDGPGIKPEQRKHLFQPFVrgdSARStSGTGLGLAIVQRIVDNHNGM 419
Cdd:PRK13837 581 RVDIslsraklrapkvlSHGVLPPGRYVLlrVSDTGAGIDEAVLPHIFEPFF---TTRA-GGTGLGLATVHGIVSAHAGY 656
|
170 180 190
....*....|....*....|....*....|.
gi 501085031 420 LEIGSSERGGLSIRAWLPiPVARVPGSTKDA 450
Cdd:PRK13837 657 IDVQSTVGRGTRFDVYLP-PSSKVPVAPQAF 686
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
343-437 |
4.74e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 62.34 E-value: 4.74e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 343 NMVVNAARYG----NGWIKVSSGTEPHRAWFQVEDDGPGIKPEQRKHLFQPFVRGDSARSTSGTGLGLAIVQRIVDNHNG 418
Cdd:cd16921 7 NLLGNAIKFRrprrPPRIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRLHSREEYEGTGVGLAIVRKIIERHGG 86
|
90
....*....|....*....
gi 501085031 419 MLEIGSSERGGLSIRAWLP 437
Cdd:cd16921 87 RIWLESEPGEGTTFYFTLP 105
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
135-444 |
1.64e-11 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 66.59 E-value: 1.64e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 135 LKTWLSPNIW---VRVPLTEIHQGDFSPLFRY---TLAIMLLAIGGAWLFIRIQ-NRPLVDLEHAALQVGKGMIPPPLRE 207
Cdd:PRK15347 267 LRTQLKGPGWqqvTLYPRRNLANEALKPALQQlpfALLILVLLTSVLFLLLRRYlAKPLWRFVDIINKTGPAALEPRLPE 346
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 208 YGASEVRSVTRAFNHMAAGVKQLAD-------DRTLLMA------------------GVSHDLRTPLTRIRLATEM---- 258
Cdd:PRK15347 347 NRLDELGSIAKAYNQLLDTLNEQYDtlenkvaERTQALAeakqraeqankrksehltTISHEIRTPLNGVLGALELlqnt 426
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 259 -MGEEDGYLAESINKDIEECNAIIEQFIDYLR--TGQ-EMPMEMADLNAVLGEVIAAESGYEREIDTALQ---PGSIQVK 331
Cdd:PRK15347 427 pLTAEQMDLADTARQCTLSLLAIINNLLDFSRieSGQmTLSLEETALLPLLDQAMLTIQGPAQSKSLTLRtfvGAHVPLY 506
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 332 MH--PLSIKRAIANMVVNAARYG-NGWIKVSSGTEPHRAWFQVEDDGPGIKPEQRKHLFQPFVRGDSarSTSGTGLGLAI 408
Cdd:PRK15347 507 LHldSLRLRQILVNLLGNAVKFTeTGGIRLRVKRHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQADT--HSQGTGLGLTI 584
|
330 340 350
....*....|....*....|....*....|....*.
gi 501085031 409 VQRIVDNHNGMLEIGSSERGGLSIRAWLPIPVARVP 444
Cdd:PRK15347 585 ASSLAKMMGGELTLFSTPGVGSCFSLVLPLNEYAPP 620
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
371-437 |
1.86e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 60.49 E-value: 1.86e-11
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 501085031 371 VEDDGPGIKPEQRKHLFQPFVRGDSarstSGTGLGLAIVQRIVDNHNGMLEIGSSERGGLSIRAWLP 437
Cdd:cd16920 42 VKDTGPGIAEEVAGQLFDPFYTTKS----EGLGMGLSICRSIIEAHGGRLSVESPAGGGATFQFTLP 104
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
343-429 |
2.24e-10 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 62.34 E-value: 2.24e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 343 NMVVNAARYGNGWIKVSSGTEPHRAWFQVEDDGPGIKPEQRKHLFQPFVRGDSARstSGTGLGLAIVQRIVDNHNGMLEI 422
Cdd:PRK10815 385 NVLDNACKYCLEFVEISARQTDEHLHIVVEDDGPGIPESKRELIFDRGQRADTLR--PGQGLGLSVAREITEQYEGKISA 462
|
....*..
gi 501085031 423 GSSERGG 429
Cdd:PRK10815 463 GDSPLGG 469
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
234-293 |
3.76e-10 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 55.65 E-value: 3.76e-10
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 501085031 234 RTLLMAGVSHDLRTPLTRIRLATEMM-----GEEDGYLAESINKDIEECNAIIEQFIDYLRTGQE 293
Cdd:smart00388 2 KREFLANLSHELRTPLTAIRGYLELLldtelSEEQREYLETILREAERLLRLINDLLDLSRIEAG 66
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
234-293 |
4.94e-10 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 55.30 E-value: 4.94e-10
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 501085031 234 RTLLMAGVSHDLRTPLTRIRLATEMM-----GEEDGYLAESINKDIEECNAIIEQFIDYLRTGQE 293
Cdd:pfam00512 2 KSEFLANLSHELRTPLTAIRGYLELLrdeklDEEQREYLETILRSAERLLRLINDLLDLSRIEAG 66
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
337-429 |
7.78e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 55.93 E-value: 7.78e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 337 IKRAIANMVVNA----ARYGNGWIKVSSGTEPHRAWFQVEDDGPGIKPEQRKHLFQPFVrgdSARSTS-GTGLGLAIVQR 411
Cdd:cd16976 1 IQQVLMNLLQNAldamGKVENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFF---TTKPVGkGTGLGLSISYG 77
|
90
....*....|....*...
gi 501085031 412 IVDNHNGMLEIGSSERGG 429
Cdd:cd16976 78 IVEEHGGRLSVANEEGAG 95
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
239-423 |
1.98e-09 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 59.86 E-value: 1.98e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 239 AGVSHDLRTPL------TRIRLATEMMGEEDGYLaesinKDIEEC--N--AIIEQFIDY--LRTG----QEMPMemaDLN 302
Cdd:PRK11107 298 ANMSHELRTPLngvigfTRQTLKTPLTPTQRDYL-----QTIERSanNllAIINDILDFskLEAGklvlENIPF---SLR 369
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 303 AVLGEVIA--AESGYEREIDTALQ-PGSI--QVKMHPLSIKRAIANMVVNAARY---GNGWIKVSSGTEPHRA---WFQV 371
Cdd:PRK11107 370 ETLDEVVTllAHSAHEKGLELTLNiDPDVpdNVIGDPLRLQQIITNLVGNAIKFtesGNIDILVELRALSNTKvqlEVQI 449
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 501085031 372 EDDGPGIKPEQRKHLFQPFVRGDS--ARSTSGTGLGLAIVQRIVDNHNGmlEIG 423
Cdd:PRK11107 450 RDTGIGISERQQSQLFQAFRQADAsiSRRHGGTGLGLVITQKLVNEMGG--DIS 501
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
234-289 |
3.76e-09 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 52.60 E-value: 3.76e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 501085031 234 RTLLMAGVSHDLRTPLTRIRLATEMM------GEEDGYLAESINKDIEECNAIIEQFIDYLR 289
Cdd:cd00082 4 KGEFLANVSHELRTPLTAIRGALELLeeelldDEEQREYLERIREEAERLLRLINDLLDLSR 65
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
165-432 |
6.61e-09 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 58.16 E-value: 6.61e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 165 LAIMLLAIGGA----WLFI--RIQNRpLVDLEHAALQVGKG----MIPPP-----------LREYGAsEVRSVTRAFNHM 223
Cdd:COG4192 329 LAIALLSLLLAvlinYFYVrrRLVKR-LNALSDAMAAIAAGdldvPIPVDgndeigriarlLRVFRD-QAIEKTQELETE 406
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 224 AAGVKQLADDR---------TLLMAGV-------SHDLRTPLTRIRL---ATEMMGEEDGYLA-----ESINKDIEECNA 279
Cdd:COG4192 407 IEERKRIEKNLrqtqdeliqAAKMAVVgqtmtslAHELNQPLNAMSMylfSAKKALEQENYAQlptslDKIEGLIERMDK 486
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 280 IIEQFIDYLRTGQEmPMEMADLNAVLGEVIA-AESGYEREIDTALQPGSIQVKMHPLSIKRAIANMVVNA--ARYGNGWI 356
Cdd:COG4192 487 IIKSLRQFSRKSDT-PLQPVDLRQVIEQAWElVESRAKPQQITLHIPDDLMVQGDQVLLEQVLVNLLVNAldAVATQPQI 565
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 501085031 357 KVSSGTEPHRAWFQVEDDGPGIKPEQRkhLFQPFVRGDSArstsGTGLGLAIVQRIVDNHNGMLEIGSS-ERGGLSI 432
Cdd:COG4192 566 SVDLLSNAENLRVAISDNGNGWPLVDK--LFTPFTTTKEV----GLGLGLSICRSIMQQFGGDLYLASTlERGAMVI 636
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
234-440 |
3.03e-08 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 56.28 E-value: 3.03e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 234 RTLLMAGVSHDLRTPLTRIRLATEMMGEED---------------------GYLAESINKD-IEECNAIIE-QFIDylrt 290
Cdd:PRK09959 712 KSQFLATMSHEIRTPISSIMGFLELLSGSGlskeqrveaislayatgqsllGLIGEILDVDkIESGNYQLQpQWVD---- 787
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 291 gqeMPMEMADLNAVLGEVIAAESgyereidTALQ-----PGSIQVKMHPLSIKRAIANMVVNAARYGN-GWIKVSSG--- 361
Cdd:PRK09959 788 ---IPTLVQNTCHSFGAIAASKS-------IALScsstfPDHYLVKIDPQAFKQVLSNLLSNALKFTTeGAVKITTSlgh 857
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 362 TEPHRAWFQ--VEDDGPGIKPEQRKHLFQPFVRGDSARSTSGTGLGLAIVQRIVDNHNGMLEIGSSERGGLSIRAWLPIP 439
Cdd:PRK09959 858 IDDNHAVIKmtIMDSGSGLSQEEQQQLFKRYSQTSAGRQQTGSGLGLMICKELIKNMQGDLSLESHPGIGTTFTITIPVE 937
|
.
gi 501085031 440 V 440
Cdd:PRK09959 938 I 938
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
340-433 |
4.14e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 51.13 E-value: 4.14e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 340 AIANMVVNAARYG--NGWIKVSSGTEPHRAWFQVEDDGPGIKPEQRKHLFQPFVRGDSARSTS-GTGLGLAIVQRIVDNH 416
Cdd:cd16948 9 IIGQIVSNALKYSkqGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGRNFQeSTGMGLYLVKKLCDKL 88
|
90
....*....|....*..
gi 501085031 417 NGMLEIGSSERGGLSIR 433
Cdd:cd16948 89 GHKIDVESEVGEGTTFT 105
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
369-437 |
5.98e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 50.84 E-value: 5.98e-08
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 501085031 369 FQVEDDGPGIKPEQRKHLFQPFVrgdsarST----SGTGLGLAIVQRIVDNHNGMLEIGSSERGGLSIRAWLP 437
Cdd:cd16919 50 LEVSDTGSGMPAEVLRRAFEPFF------TTkevgKGTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
339-420 |
1.21e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 49.88 E-value: 1.21e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 339 RAIANMVVNAARY---GNGWIKVSSGTEPHRAWFQVEDDGPGIKPEQRKHLFQPFVRGDSARSTSGT--GLGLAIVQRIV 413
Cdd:cd16953 3 QVLRNLIGNAISFsppDTGRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYTERPANEAFGQhsGLGLSISRQII 82
|
....*..
gi 501085031 414 DNHNGML 420
Cdd:cd16953 83 EAHGGIS 89
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
334-436 |
2.44e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 49.00 E-value: 2.44e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 334 PLSIKRAIANMVVNAARYG--NGWIKVSSGTEPHRAWFQVEDDGPGIKPEQRKHLFQPFVrgDSARSTSG---TGLGLAI 408
Cdd:cd16945 2 PFLLRQAINNLLDNAIDFSpeGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFY--SLPRPHSGqksTGLGLAF 79
|
90 100
....*....|....*....|....*...
gi 501085031 409 VQRIVDNHNGMLEIGSSERGGLSIrAWL 436
Cdd:cd16945 80 VQEVAQLHGGRITLRNRPDGVLAF-LTL 106
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
249-439 |
3.94e-07 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 51.16 E-value: 3.94e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 249 LTRIRLATEMMGEEDGYLAESINKDIEECNAIIEQFIDYLRT--GQEMPMEMADLNavLGEVIaaesgyEREIDTALQPG 326
Cdd:COG4585 69 LSAIKLQLEAARRLLDADPEAAREELEEIRELAREALAELRRlvRGLRPPALDDLG--LAAAL------EELAERLLRAA 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 327 SIQVKMH--------PLSIKRAIANMV----VNAARYGNG-WIKVSSGTEPHRAWFQVEDDGPGIKPEQRKhlfqpfvrg 393
Cdd:COG4585 141 GIRVELDvdgdpdrlPPEVELALYRIVqealTNALKHAGAtRVTVTLEVDDGELTLTVRDDGVGFDPEAAP--------- 211
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 501085031 394 dsarstsGTGLGLAIVQRIVDNHNGMLEIGSSERGGLSIRAWLPIP 439
Cdd:COG4585 212 -------GGGLGLRGMRERAEALGGTLTIGSAPGGGTRVRATLPLA 250
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
233-434 |
4.57e-07 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 52.25 E-value: 4.57e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 233 DRTLLMAGVSHDLRTPL------TRIRLATEMMGEEDGYL------AES---INKDIEECNAIIEQFIDYLRTGQEMPME 297
Cdd:PRK11091 282 DKTTFISTISHELRTPLngivglSRILLDTELTAEQRKYLktihvsAITlgnIFNDIIDMDKMERRKLQLDNQPIDFTDF 361
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 298 MADLNAVLGeVIAAESGYEREIDTaLQPGSIQVKMHPLSIKRAIANMVVNAARYG-NGWIKVSSGTEPH-RAWFQVEDDG 375
Cdd:PRK11091 362 LADLENLSG-LQAEQKGLRFDLEP-LLPLPHKVITDGTRLRQILWNLISNAVKFTqQGGVTVRVRYEEGdMLTFEVEDSG 439
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 501085031 376 PGIKPEQRKHLFQPFVR---GDSARSTSGTGLGLAIVQRIVDNHNGMLEIGSSERGG----LSIRA 434
Cdd:PRK11091 440 IGIPEDELDKIFAMYYQvkdSHGGKPATGTGIGLAVSKRLAQAMGGDITVTSEEGKGscftLTIHA 505
|
|
| RsbW |
COG2172 |
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
344-414 |
1.68e-06 |
|
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 46.83 E-value: 1.68e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 501085031 344 MVVNAARYGN-----GWIKVSSGTEPHRAWFQVEDDGPGIKPEQRKhlfqpfvrgDSARSTSGTGLGLAIVQRIVD 414
Cdd:COG2172 42 AVTNAVRHAYggdpdGPVEVELELDPDGLEIEVRDEGPGFDPEDLP---------DPYSTLAEGGRGLFLIRRLMD 108
|
|
| HAMP |
pfam00672 |
HAMP domain; |
177-229 |
1.00e-05 |
|
HAMP domain;
Pssm-ID: 459898 [Multi-domain] Cd Length: 53 Bit Score: 42.61 E-value: 1.00e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 501085031 177 LFIRIQNRPLVDLEHAALQVGKGMIPPPLREYGASEVRSVTRAFNHMAAGVKQ 229
Cdd:pfam00672 1 LLARRILRPLRRLAEAARRIASGDLDVRLPVSGRDEIGELARAFNQMAERLRE 53
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
296-442 |
1.49e-05 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 47.21 E-value: 1.49e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 296 MEMADLNAVLGEVIAAesgyereIDTALQPGSIQVKMH----PLSIKRAIA-----N-MVVNAARYG-----NGWIKVSS 360
Cdd:COG3920 356 WEGVDLRDYLRELLEP-------LRDSYGGRGIRIELDgpdvELPADAAVPlglilNeLVTNALKHAflsgeGGRIRVSW 428
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 361 GTEPHRAWFQVEDDGPGIKPEqrkhlfqpfvrgdsARSTSGTGLGLAIVQRIVDNHNGMLEIGSSErgGLSIRAWLPIPV 440
Cdd:COG3920 429 RREDGRLRLTVSDNGVGLPED--------------VDPPARKGLGLRLIRALVRQLGGTLELDRPE--GTRVRITFPLAE 492
|
..
gi 501085031 441 AR 442
Cdd:COG3920 493 LA 494
|
|
| HAMP |
COG2770 |
HAMP domain [Signal transduction mechanisms]; |
1-350 |
1.93e-05 |
|
HAMP domain [Signal transduction mechanisms];
Pssm-ID: 442051 [Multi-domain] Cd Length: 631 Bit Score: 47.03 E-value: 1.93e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 1 MRRMRFSPRSSFARTLLLIVTLLFVSLVTTYLVVLNFAILPSLQQFNKVLAYEVRMLMTDKLQLEDGTQLVVPPAFRREI 80
Cdd:COG2770 56 LLLLLLAALVLLALLLAAALLLLLLLLSLVALAALLLALLLLLLLALLLLLAALLLLLLLAALALLLLLLLLLAALLALL 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 81 YRELGISLYSNEAAEEAGLRWAQHYEFLSHQMAQQLGGPTEVRVEVNKSSPVVWLKTWLSPNIWVRVPLTEIHQGDFSPL 160
Cdd:COG2770 136 LALALLALLLGLAAARLLLAALLALAAALALALGAGELLLLADLAAAIAALLAALLLLLLGGLLLVVLLEAALAALLLLL 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 161 FrYTLAIMLLAIGGAWLFIRIQNRPLVDLEHAALQVGKGMIPPPLREYGASEVRSVTRAFNHMAAGVKQLADDRTLLMAG 240
Cdd:COG2770 216 L-LALLALLLALLLALLLARRITRPLRRLAEAARRIAAGDLDVRIPVSRKDEIGELARAFNRMADSLRESIEEAEEEEEL 294
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 241 VSHDLRTPLTRIRLATEMMGEEDGYLAESINKDIEECNAIIEQFIDYLRTGQEMPMEMADLNAVLGEVIAAESGYEREID 320
Cdd:COG2770 295 AEAELARLLEALLELLLALLLLLLALLLLAAAALLLELLLLLLLALLLLLLLAADLLLALALAALLLLLALELLLEAELL 374
|
330 340 350
....*....|....*....|....*....|
gi 501085031 321 TALQPGSIQVKMHPLSIKRAIANMVVNAAR 350
Cdd:COG2770 375 VLLALEALALEAELAAVLALLAALAAALLL 404
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
336-424 |
2.79e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 43.66 E-value: 2.79e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 336 SIKRAIANMVVNAARYGNG--WIKVSSGTEPHRAWFQVEDDGPGIKPEQRKHLFQPFVRGDSARSTS--GTGLGLAIVQR 411
Cdd:cd16947 20 ALQRILKNLISNAIKYGSDgkFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSRNSAkqGNGLGLTITKR 99
|
90
....*....|...
gi 501085031 412 IVDNHNGMLEIGS 424
Cdd:cd16947 100 LAESMGGSIYVNS 112
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
334-444 |
1.11e-04 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 44.58 E-value: 1.11e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 334 PLSIKRAIANMVVNAARYGN-GWIKVSSGTEPHRAWFQVEDDGPGIKPEQRKHLFQPFVRGDSA--RSTSGTGLGLAIVQ 410
Cdd:PRK10841 560 PMRLQQVISNLLSNAIKFTDtGCIVLHVRVDGDYLSFRVRDTGVGIPAKEVVRLFDPFFQVGTGvqRNFQGTGLGLAICE 639
|
90 100 110
....*....|....*....|....*....|....*.
gi 501085031 411 RIVDNHNGMLEIGSSERGG--LSIRawLPIPVARVP 444
Cdd:PRK10841 640 KLINMMDGDISVDSEPGMGsqFTIR--IPLYGAQYP 673
|
|
| HAMP |
smart00304 |
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; |
180-232 |
1.22e-04 |
|
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
Pssm-ID: 197640 [Multi-domain] Cd Length: 53 Bit Score: 39.54 E-value: 1.22e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 501085031 180 RIQNRPLVDLEHAALQVGKGMIPPPLREYGASEVRSVTRAFNHMAAGVKQLAD 232
Cdd:smart00304 1 RRLLRPLRRLAEAAQRIADGDLTVRLPVDGRDEIGELARAFNEMADRLEETIA 53
|
|
| NarQ |
COG3850 |
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction ... |
43-320 |
2.78e-04 |
|
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction mechanisms];
Pssm-ID: 443059 [Multi-domain] Cd Length: 448 Bit Score: 43.33 E-value: 2.78e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 43 LQQFNKVLAYEVRMLMTDKLQLEDGTQLVVPPAFRREIYRELGISLYSNEAAEEAGLRWAQHYEFLSHQMAQQLGGPTEV 122
Cdd:COG3850 3 ELLLLALALLRLLLALLALLLLALLLLSLLALLLLLERTLLRLLSLLASAGLLAALLAALLLLLSLGLLALLLALLLLLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 123 RVEVNKSSPVVWLKTWLSPNIWVRVPLTEIHQGDFSPLFRYTLAIMLLAIGGAWLFIRIQNRPLVDLEHAALQVGKGMIP 202
Cdd:COG3850 83 LLLLAALLSLLLLLLLLLLLLLLLLLLLLAAAINRKLALLRLLLALLLALLLAYLLRRRIVRPLRRLTQAAERIARGDFD 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 203 PPLREYGASEVRSVTRAFNHMAAGVKQLADDRTLLMAGVSHDLRTPLTRIRLATEMMGEEDGYLAESINKDIEECNAIIE 282
Cdd:COG3850 163 ARVPVSGRDELGTLARAFNRMADELQELYAELEEEEELEAELELLALLDELLLLAALLLLLALLLALLLAALLAALLLLL 242
|
250 260 270
....*....|....*....|....*....|....*...
gi 501085031 283 QFIDYLRTGQEMPMEMADLNAVLGEVIAAESGYEREID 320
Cdd:COG3850 243 LLQDALAESELLALNILAGLLELLLALLLLLLASALLL 280
|
|
| HAMP |
cd06225 |
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ... |
184-225 |
7.84e-04 |
|
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.
Pssm-ID: 381743 [Multi-domain] Cd Length: 45 Bit Score: 37.04 E-value: 7.84e-04
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 501085031 184 RPLVDLEHAALQVGKGMIPPPLREYGASEVRSVTRAFNHMAA 225
Cdd:cd06225 2 RPLRRLTEAARRIAEGDLDVRVPVRSKDEIGELARAFNQMAE 43
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
350-424 |
1.22e-03 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 41.05 E-value: 1.22e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 501085031 350 RYGNGWIKVssgtephrawfQVEDDGPGIKPEQRKHLFQpfvRGDSARStSGTGLGLAIVQRIVDNHNGMLEIGS 424
Cdd:PRK11086 462 HYRNGWLHC-----------EVSDDGPGIAPDEIDAIFD---KGYSTKG-SNRGVGLYLVKQSVENLGGSIAVES 521
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
237-438 |
1.92e-03 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 40.42 E-value: 1.92e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 237 LMAGVSHDLRTPLTRIRLATEMMG----------EEDGYLAESINKDIEECNAIIEQFIDYLRTgQEMPMEMADLNAV-- 304
Cdd:PRK13557 166 LTGGIAHDFNNLLQVMSGYLDVIQaalshpdadrGRMARSVENIRAAAERAATLTQQLLAFARK-QRLEGRVLNLNGLvs 244
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501085031 305 -LGEVIAAESGYEREIDTALQPGSIQVKMHPLSIKRAIANMVVNA--ARYGNGWIKVSSG----TEPHRAWFQ------- 370
Cdd:PRK13557 245 gMGELAERTLGDAVTIETDLAPDLWNCRIDPTQAEVALLNVLINArdAMPEGGRVTIRTRnveiEDEDLAMYHglppgry 324
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 501085031 371 ----VEDDGPGIKPEQRKHLFQPFVrgDSARSTSGTGLGLAIVQRIVDNHNGMLEIGSSERGGLSIRAWLPI 438
Cdd:PRK13557 325 vsiaVTDTGSGMPPEILARVMDPFF--TTKEEGKGTGLGLSMVYGFAKQSGGAVRIYSEVGEGTTVRLYFPA 394
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