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Conserved domains on  [gi|501231696|ref|WP_012274714|]
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MULTISPECIES: amino acid ABC transporter permease [Pseudomonas]

Protein Classification

amino acid ABC transporter permease( domain architecture ID 11433582)

amino acid ABC transporter permease is the transmembrane (TM) subunit of a periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporter which binds and transports amino acids

Gene Ontology:  GO:0140359|GO:0042626|GO:0006865
PubMed:  25750732|24638992
TCDB:  3.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 18-219 9.21e-62

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


:

Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 191.83  E-value: 9.21e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501231696  18 GGAAQTLAISALGILFATLGGVLYGVLATLGNRALNIALQVYLELFRAIPVLVWLYLVFFGLPiFFALSIPSFWCAVLVL 97
Cdd:COG0765   17 EGLLVTLLLTVLAIVLGLVLGLLLALARLSPNPVLRWLATAYVEFFRGTPLLVQLFFIYFGLP-LLGIDLSPFVAAVIAL 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501231696  98 ALWGASEVGEVVRGALRSLPRGQREAGLSIGLAGWQLYGYVLLPQALKRMTPPTINIYTRIIKTSSLAVLIGVVEVIKAG 177
Cdd:COG0765   96 TLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRIILPQALRIILPPLGNEFISLLKDTSLVSVIGVPELTRAA 175

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 501231696 178 QQIIERTYESVLIYGALFLFFFIVCYPLSAASRVLERRWAHS 219
Cdd:COG0765  176 QQIASRTFRPFEVYLVAALIYLVLTLPLSLLARRLERRLARG 217
 
Name Accession Description Interval E-value
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 18-219 9.21e-62

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 191.83  E-value: 9.21e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501231696  18 GGAAQTLAISALGILFATLGGVLYGVLATLGNRALNIALQVYLELFRAIPVLVWLYLVFFGLPiFFALSIPSFWCAVLVL 97
Cdd:COG0765   17 EGLLVTLLLTVLAIVLGLVLGLLLALARLSPNPVLRWLATAYVEFFRGTPLLVQLFFIYFGLP-LLGIDLSPFVAAVIAL 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501231696  98 ALWGASEVGEVVRGALRSLPRGQREAGLSIGLAGWQLYGYVLLPQALKRMTPPTINIYTRIIKTSSLAVLIGVVEVIKAG 177
Cdd:COG0765   96 TLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRIILPQALRIILPPLGNEFISLLKDTSLVSVIGVPELTRAA 175

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 501231696 178 QQIIERTYESVLIYGALFLFFFIVCYPLSAASRVLERRWAHS 219
Cdd:COG0765  176 QQIASRTFRPFEVYLVAALIYLVLTLPLSLLARRLERRLARG 217
glnP PRK09494
glutamine ABC transporter permease protein; Reviewed
 19-215 5.47e-36

glutamine ABC transporter permease protein; Reviewed


Pssm-ID: 181907 [Multi-domain]  Cd Length: 219  Bit Score: 125.94  E-value: 5.47e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501231696  19 GAAQTLAISALGILFATLGGVLYGVLATLGNRALNIALQVYLELFRAIPVLVWLYLVFFGLPIFFA-LSIPSFWCAVLVL 97
Cdd:PRK09494  18 GAKMTLWISVLGLAGGLVIGLLAGFARAYGGWIANHIALVFIELIRGTPIVVQVMFIYFALPMAFNdLRIDPFTAAVVTI 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501231696  98 ALWGASEVGEVVRGALRSLPRGQREAGLSIGLAGWQLYGYVLLPQALKRMTPPTINIYTRIIKTSSLAVLIGVVEVIKAG 177
Cdd:PRK09494  98 MINSGAYIAEITRGAVLSIHKGFREAGLALGLSRRETLRYVIGPLALRRMLPPLGNQWIISIKDTSLFIVIGVAELTRQG 177

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 501231696 178 QQIIERTYESVLIYGALFLFFFIVCYPLSAASRVLERR 215
Cdd:PRK09494 178 QEIIAGNFRALEIWSAVAVIYLIITLVLSFILRRLERR 215
ectoine_ehuC TIGR03004
ectoine/hydroxyectoine ABC transporter, permease protein EhuC; Members of this family are ...
 19-215 5.94e-25

ectoine/hydroxyectoine ABC transporter, permease protein EhuC; Members of this family are presumed to act as permease subunits of ectoine ABC transporters. Operons containing this gene also contain the other genes of the ABC transporter and typically are found next to either ectoine utilization or ectoine biosynthesis operons. Permease subunits EhuC and EhuD are homologous.


Pssm-ID: 132049 [Multi-domain]  Cd Length: 214  Bit Score: 97.23  E-value: 5.94e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501231696   19 GAAQTLAISALGILFATLGGVLYGVLATLGNRALNIALQVYLELFRAIPVLVWLYLVFFGLPiFFALSIPSFWCAVLVLA 98
Cdd:TIGR03004  10 GAWVTMQITLAGSVLATVLAFFAGLGRVSGGPILRTVALCYIEVFRGTSLLVQLFWFYFVLP-LIGLSLDPVTTGVMVLG 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501231696   99 LWGASEVGEVVRGALRSLPRGQREAGLSIGLAGWQLYGYVLLPQALKRMTPPTINIYTRIIKTSSLAVLIGVVEVIKAGQ 178
Cdd:TIGR03004  89 LHAGAYGAEIVRGALSSVSVQQLEACRALNFTRFQTLRRISLPQALVEMMPAFGNLAIELLKLTSLVSLISLADLTFAAQ 168

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 501231696  179 QIIERTYESVLIYGALFLFFFIVCYPLSAASRVLERR 215
Cdd:TIGR03004 169 SIRNLTLDTLSIFAITLLCYFVMALIIMLIMRVLERV 205
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 23-201 8.34e-13

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 64.22  E-value: 8.34e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501231696  23 TLAISALGILFATLGGVLYGVLATLGNRALNIALQVYLELFRAIPVLVWLYLVFFGLPIFFALSIP--SFWCAVLVLALW 100
Cdd:cd06261    4 TLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGWGILpgLGLPALILALLL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501231696 101 GASEVGEVVRGALRSLPRGQREAGLSIGLAGWQLYGYVLLPQALKRMTPPTINIYTRIIKTSSLAVLIGVVEVIKAG--- 177
Cdd:cd06261   84 IAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEAPGPGtgl 163

                        170       180
                 ....*....|....*....|....
gi 501231696 178 QQIIERTYESVLIYGALFLFFFIV 201
Cdd:cd06261  164 LLIFAILFPGDLGVAAAVALILLL 187
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 43-203 8.66e-07

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 47.68  E-value: 8.66e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501231696   43 VLATLGNRALNIALQVYLELFRAIPVLVWLYLVFFglpIFFALSIPSFWCAVLVLALWGASE-VGEVVRGALRSLPRGQR 121
Cdd:pfam00528   7 IAALRRGRRLDRLLRPLIDLLQALPSFVLAILLVV---IAILSILGHGILPAIILALLGWAGyARLIRRAALRSLPSDLV 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501231696  122 EAGLSIGLAGWQLYGYVLLPQALKRMTPPTINIYTRIIKTSSLAVLIGVVEVIkaGQQIIERTYESVLIYGALFLFFFIV 201
Cdd:pfam00528  84 EAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSWPGL--GLLLIEAILGYDYPEIQGPVLAAAL 161


                  ..
gi 501231696  202 CY 203
Cdd:pfam00528 162 IL 163
 
Name Accession Description Interval E-value
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 18-219 9.21e-62

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 191.83  E-value: 9.21e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501231696  18 GGAAQTLAISALGILFATLGGVLYGVLATLGNRALNIALQVYLELFRAIPVLVWLYLVFFGLPiFFALSIPSFWCAVLVL 97
Cdd:COG0765   17 EGLLVTLLLTVLAIVLGLVLGLLLALARLSPNPVLRWLATAYVEFFRGTPLLVQLFFIYFGLP-LLGIDLSPFVAAVIAL 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501231696  98 ALWGASEVGEVVRGALRSLPRGQREAGLSIGLAGWQLYGYVLLPQALKRMTPPTINIYTRIIKTSSLAVLIGVVEVIKAG 177
Cdd:COG0765   96 TLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRIILPQALRIILPPLGNEFISLLKDTSLVSVIGVPELTRAA 175

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 501231696 178 QQIIERTYESVLIYGALFLFFFIVCYPLSAASRVLERRWAHS 219
Cdd:COG0765  176 QQIASRTFRPFEVYLVAALIYLVLTLPLSLLARRLERRLARG 217
glnP PRK09494
glutamine ABC transporter permease protein; Reviewed
 19-215 5.47e-36

glutamine ABC transporter permease protein; Reviewed


Pssm-ID: 181907 [Multi-domain]  Cd Length: 219  Bit Score: 125.94  E-value: 5.47e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501231696  19 GAAQTLAISALGILFATLGGVLYGVLATLGNRALNIALQVYLELFRAIPVLVWLYLVFFGLPIFFA-LSIPSFWCAVLVL 97
Cdd:PRK09494  18 GAKMTLWISVLGLAGGLVIGLLAGFARAYGGWIANHIALVFIELIRGTPIVVQVMFIYFALPMAFNdLRIDPFTAAVVTI 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501231696  98 ALWGASEVGEVVRGALRSLPRGQREAGLSIGLAGWQLYGYVLLPQALKRMTPPTINIYTRIIKTSSLAVLIGVVEVIKAG 177
Cdd:PRK09494  98 MINSGAYIAEITRGAVLSIHKGFREAGLALGLSRRETLRYVIGPLALRRMLPPLGNQWIISIKDTSLFIVIGVAELTRQG 177

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 501231696 178 QQIIERTYESVLIYGALFLFFFIVCYPLSAASRVLERR 215
Cdd:PRK09494 178 QEIIAGNFRALEIWSAVAVIYLIITLVLSFILRRLERR 215
ArtM COG4160
ABC-type arginine/histidine transport system, permease component [Amino acid transport and ...
 19-216 5.55e-32

ABC-type arginine/histidine transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 443325 [Multi-domain]  Cd Length: 229  Bit Score: 115.96  E-value: 5.55e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501231696  19 GAAQTLAISALGILFATLGGVLYGVLATLGNRALNIALQVYLELFRAIPVLVWLYLVFFGLPIFFALSIPSFW------- 91
Cdd:COG4160   16 GLPLTLQLLALSLLLGFLLAVPLALARASGNRLLRWPARGYIYVFRGTPLLVQLFLIYYGLGQFEWVRESWLWpllrdpw 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501231696  92 -CAVLVLALWGASEVGEVVRGALRSLPRGQREAGLSIGLAGWQLYGYVLLPQALKRMTPPTINIYTRIIKTSSLAVLIGV 170
Cdd:COG4160   96 fCALLALTLNTAAYTAEIFRGAIRAVPKGEIEAARALGMSRWQTFRRIILPSALRRALPAYSNEVILMLKATALASTITV 175

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 501231696 171 VEVIKAGQQIIERTYESVLIYGALFLFFFIVCYPLSAASRVLERRW 216
Cdd:COG4160  176 MDLTGVARRIYSRTYDPFEPFLIAALIYLVITFLLTRLFRLLERRL 221
PRK15100 PRK15100
cystine ABC transporter permease;
19-215 1.33e-25

cystine ABC transporter permease;


Pssm-ID: 185055 [Multi-domain]  Cd Length: 220  Bit Score: 99.05  E-value: 1.33e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501231696  19 GAAQTLAISALGILFATLGGVLYGVLATLGNRALNIALQVYLELFRAIPVLVWLYLVFFGLPIFfALSIPSFWCAVLVLA 98
Cdd:PRK15100  18 GAGYTLQLSIGGMFFGLLLGFILALMRLSPIWPVRWLARFYVSIFRGTPLIAQLFMIYYGLPQF-GIELDPIPAAMIGLS 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501231696  99 LWGASEVGEVVRGALRSLPRGQREAGLSIGLAGWQLYGYVLLPQALKRMTPPTINIYTRIIKTSSLAVLIGVVEVIKAGQ 178
Cdd:PRK15100  97 LNTAAYAAETLRAAISSIDKGQWEAAASIGMTRWQTLRRAILPQAARTALPPLSNSFISLVKDTSLAATIQVPELFRQAQ 176

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 501231696 179 QIIERTYESVLIYGALFLFFFIVCYPLSAASRVLERR 215
Cdd:PRK15100 177 LITSRTLEVFTMYLAASLIYWIMATVLSALQNRFENQ 213
ectoine_ehuC TIGR03004
ectoine/hydroxyectoine ABC transporter, permease protein EhuC; Members of this family are ...
 19-215 5.94e-25

ectoine/hydroxyectoine ABC transporter, permease protein EhuC; Members of this family are presumed to act as permease subunits of ectoine ABC transporters. Operons containing this gene also contain the other genes of the ABC transporter and typically are found next to either ectoine utilization or ectoine biosynthesis operons. Permease subunits EhuC and EhuD are homologous.


Pssm-ID: 132049 [Multi-domain]  Cd Length: 214  Bit Score: 97.23  E-value: 5.94e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501231696   19 GAAQTLAISALGILFATLGGVLYGVLATLGNRALNIALQVYLELFRAIPVLVWLYLVFFGLPiFFALSIPSFWCAVLVLA 98
Cdd:TIGR03004  10 GAWVTMQITLAGSVLATVLAFFAGLGRVSGGPILRTVALCYIEVFRGTSLLVQLFWFYFVLP-LIGLSLDPVTTGVMVLG 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501231696   99 LWGASEVGEVVRGALRSLPRGQREAGLSIGLAGWQLYGYVLLPQALKRMTPPTINIYTRIIKTSSLAVLIGVVEVIKAGQ 178
Cdd:TIGR03004  89 LHAGAYGAEIVRGALSSVSVQQLEACRALNFTRFQTLRRISLPQALVEMMPAFGNLAIELLKLTSLVSLISLADLTFAAQ 168

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 501231696  179 QIIERTYESVLIYGALFLFFFIVCYPLSAASRVLERR 215
Cdd:TIGR03004 169 SIRNLTLDTLSIFAITLLCYFVMALIIMLIMRVLERV 205
ectoine_ehuD TIGR03003
ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are ...
 19-215 1.84e-20

ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are presumed to act as permease subunits of ectoine ABC transporters. Operons containing this gene also contain the other genes of the ABC transporter and typically are found next to either ectoine utilization or ectoine biosynthesis operons.


Pssm-ID: 132048 [Multi-domain]  Cd Length: 212  Bit Score: 85.29  E-value: 1.84e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501231696   19 GAAQTLAISALGILFATLGGVLYGVLATLGNRALNIALQVYLELFRAIPVLVWLYLVFFGLPIFfALSIPSFWCAVLVLA 98
Cdd:TIGR03003  16 GLKITILATALGFAIAAVLGLVFAILRRSAPTPISWPTSFVVEFIRGTPLLVQLYFLYYVLPDI-GIRLPALVAGVLGLG 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501231696   99 LWGASEVGEVVRGALRSLPRGQREAGLSIGLAGWQLYGYVLLPQALKRMTPPTINIYTRIIKTSSLAVLIGVVEVIKAGQ 178
Cdd:TIGR03003  95 LHYATYAAEVYRAGIEAVPRGQWEAATALNLTARQTYRHIILPQAIPPIIPALGNYLVAMFKETPVLSAITVLELMNQAK 174

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 501231696  179 QIIERTYESVLIYGALFLFFFIVCYPLSAASRVLERR 215
Cdd:TIGR03003 175 SIGNSTFRYLEPMTLVGVFFLILSIISVFFLRRLEAR 211
artM PRK11122
arginine ABC transporter permease ArtM;
18-215 8.20e-20

arginine ABC transporter permease ArtM;


Pssm-ID: 182978 [Multi-domain]  Cd Length: 222  Bit Score: 83.85  E-value: 8.20e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501231696  18 GGAAQTLAISALGILFATLGGVLYGVLATLGNRALNIALQVYLELFRAIPVLVWLYLVFFGLPIFFAL-SIPSFW----- 91
Cdd:PRK11122  10 KGLHTSLTLTVASLLVALVLALIFTIILTLKTPVLVWLVRGYITLFTGTPLLVQIFLIYYGPGQFPWLqEYPWLWhllsq 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501231696  92 ---CAVLVLALWGASEVGEVVRGALRSLPRGQREAGLSIGLAGWQLYgYVLLPQALKRMTPPTINIYTRIIKTSSLAVLI 168
Cdd:PRK11122  90 pwlCAMLALALNSAAYSTQLFYGAVRAIPEGQWQSCAALGMSKKQTL-RILLPYAFKRALSSYSNEVVLVFKSTSLAYTI 168

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 501231696 169 GVVEVIKAGQQIIERTYEsVLIYGALFLFFFIVCYPLSAASRVLERR 215
Cdd:PRK11122 169 TLMDVMGYSQLLYGRTYD-VMVFGAAGIIYLVVNGLLTLLMRLIERK 214
PRK15069 PRK15069
histidine ABC transporter permease HisM;
19-216 2.17e-16

histidine ABC transporter permease HisM;


Pssm-ID: 185029 [Multi-domain]  Cd Length: 234  Bit Score: 75.09  E-value: 2.17e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501231696  19 GAAQTLAISALGILFATLGGVLYGVLATLGNRALNIALQVYLELFRAIPVLVWLYLVFFGL---------PIFFALSIPS 89
Cdd:PRK15069  22 GLAITLWLLVASVVIGFVLAVPLAIARVSSNKWIRFPVWLYTYVFRGTPLYVQLLVFYTGMysleivrgtDLLDAFFRSG 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501231696  90 FWCAVLVLALWGASEVGEVVRGALRSLPRGQREAGLSIGLAGWQLYGYVLLPQALKRMTPPTINIYTRIIKTSSLAVLIG 169
Cdd:PRK15069 102 LNCTILAFTLNTCAYTTEIFAGAIRSVPHGEIEAARAYGMSTFKLYRRIILPSALRRALPAYSNEVILMLHATTLAFTAT 181

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 501231696 170 VVEVIKAGQQIIERTYESVLIYGALFLFFFIVCYPLSAASRVLERRW 216
Cdd:PRK15069 182 VPDILKIARDINSATYQPFQAFGIAAVLYLIISFVLISLFRRAERRW 228
HEQRo_perm_3TM TIGR01726
amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; This ...
 19-111 2.94e-14

amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; This model represents one of several classes of multiple membrane spanning regions found immediately N-terminal to the domain described by pfam00528, binding-protein-dependent transport systems inner membrane component. The region covered by this model generally is predicted to contain three transmembrane helices. Substrate specificities attributed to members of this family include histidine, arginine, glutamine, glutamate, and (in Agrobacterium) the opines octopine and nopaline. [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 130787 [Multi-domain]  Cd Length: 99  Bit Score: 66.02  E-value: 2.94e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501231696   19 GAAQTLAISALGILFATLGGVLYGVLATLGNRALNIALQVYLELFRAIPVLVWLYLVFFGLPiFFALSIPSFWCAVLVLA 98
Cdd:TIGR01726   8 GLLLTLLLSVLSILLGLVLGLLLALLRLSGNRPLRWIATVYVELFRGTPLLVQLFFIYFGLP-LIGIRLSPLTAAVIALT 86

                          90
                  ....*....|...
gi 501231696   99 LWGASEVGEVVRG 111
Cdd:TIGR01726  87 LFYGAYLAEIFRG 99
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 23-201 8.34e-13

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 64.22  E-value: 8.34e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501231696  23 TLAISALGILFATLGGVLYGVLATLGNRALNIALQVYLELFRAIPVLVWLYLVFFGLPIFFALSIP--SFWCAVLVLALW 100
Cdd:cd06261    4 TLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGWGILpgLGLPALILALLL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501231696 101 GASEVGEVVRGALRSLPRGQREAGLSIGLAGWQLYGYVLLPQALKRMTPPTINIYTRIIKTSSLAVLIGVVEVIKAG--- 177
Cdd:cd06261   84 IAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEAPGPGtgl 163

                        170       180
                 ....*....|....*....|....
gi 501231696 178 QQIIERTYESVLIYGALFLFFFIV 201
Cdd:cd06261  164 LLIFAILFPGDLGVAAAVALILLL 187
PRK15135 PRK15135
histidine ABC transporter permease HisQ;
19-218 1.59e-12

histidine ABC transporter permease HisQ;


Pssm-ID: 185089 [Multi-domain]  Cd Length: 228  Bit Score: 64.43  E-value: 1.59e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501231696  19 GAAQTLAISALGILFATLGGVLYGVLATLGNRALNIALQVYLELFRAIPVLVWLYLVFFGLPI----------FFALSIP 88
Cdd:PRK15135  12 GALVTLELALSSVVLAVIIGLIGAGGKLSQNRLLGLIFEGYTTLIRGVPDLVLMLLIFYGLQIalnsvtealgVGQIDID 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501231696  89 SFWCAVLVLALWGASEVGEVVRGALRSLPRGQREAGLSIGLAGWQLYGYVLLPQALKRMTPPTINIYTRIIKTSSLAVLI 168
Cdd:PRK15135  92 PMVAGIITLGFIYGAYFTETFRGAFMAVPKGHIEAATAFGFTRGQVFRRIMFPAMMRYALPGIGNNWQVILKATALVSLL 171

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 501231696 169 GVVEVIKAGQQIIERTYES---VLIYGALFLFFFIVCyplSAASRVLERRWAH 218
Cdd:PRK15135 172 GLEDVVKATQLAGKSTWEPfyfAIVCGVIYLVFTTVS---NGVLLWLERRYSV 221
PRK15107 PRK15107
glutamate/aspartate ABC transporter permease GltK;
19-215 7.28e-11

glutamate/aspartate ABC transporter permease GltK;


Pssm-ID: 185062 [Multi-domain]  Cd Length: 224  Bit Score: 59.46  E-value: 7.28e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501231696  19 GAAQTLAISALGILFATLGGVLYGVLATLGNRALNIALQVYLELFRAIP---VLVWLYLVFFG-LPIFFALSIPS---FW 91
Cdd:PRK15107  19 GLVITLKITVTAVVIGILWGTILAVMRLSSFKPVAWFAKAYVNVFRSIPlvmVLLWFYLIVPGfLQNVLGLSPKTdirLI 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501231696  92 CAVLVLALWGASEVGEVVRGALRSLPRGQREAGLSIGLAGWQLYGYVLLPQALKRMTPPTINIYTRIIKTSSLAVLIGVV 171
Cdd:PRK15107  99 SAMVAFSMFEAAYYSEIIRAGIQSISRGQSSAALALGMTHWQSMKLIILPQAFRAMVPLLLTQGIVLFQDTSLVYVLSLA 178

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 501231696 172 EVIKAGQQIIER---TYESVLIYGALflfFFIVCYPLSAASRVLERR 215
Cdd:PRK15107 179 DFFRTASTIGERdgtQVEMILFAGFV---YFVISLSASLLVSYLKKR 222
PRK11123 PRK11123
arginine ABC transporter permease ArtQ;
24-215 1.07e-10

arginine ABC transporter permease ArtQ;


Pssm-ID: 182979 [Multi-domain]  Cd Length: 238  Bit Score: 59.31  E-value: 1.07e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501231696  24 LAISAL------GILFATLGGVLYGVLATLGN------RALNIALQVYLELFRAIPVLVWL------YLVFFGLPIFFA- 84
Cdd:PRK11123  17 LAVCALivglalAMLFAVWESAKWRPVAWPGTalvtllRGLPEILVVLFIYFGSSQLLLTLsdgftlNLGFVQIPVQMDi 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501231696  85 --LSIPSFWCAVLVLALWGASEVGEVVRGALRSLPRGQREAGLSIGLAGWQLYGYVLLPQALKRMTPPTINIYTRIIKTS 162
Cdd:PRK11123  97 enFEVSPFLCGVIALSLLYAAYASQTLRGALKAVPVGQWESGQALGLSKSAIFFRLVMPQMWRHALPGLGNQWLVLLKDT 176

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 501231696 163 SLAVLIGVVEVIKAGQQIIERTYESVLIYGALFLFFFIVCYPLSAASRVLERR 215
Cdd:PRK11123 177 ALVSLISVNDLMLQTKSIATRTQEPFTWYIIAAAIYLVITLISQYILKRIELR 229
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 43-203 8.66e-07

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 47.68  E-value: 8.66e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501231696   43 VLATLGNRALNIALQVYLELFRAIPVLVWLYLVFFglpIFFALSIPSFWCAVLVLALWGASE-VGEVVRGALRSLPRGQR 121
Cdd:pfam00528   7 IAALRRGRRLDRLLRPLIDLLQALPSFVLAILLVV---IAILSILGHGILPAIILALLGWAGyARLIRRAALRSLPSDLV 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501231696  122 EAGLSIGLAGWQLYGYVLLPQALKRMTPPTINIYTRIIKTSSLAVLIGVVEVIkaGQQIIERTYESVLIYGALFLFFFIV 201
Cdd:pfam00528  84 EAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSWPGL--GLLLIEAILGYDYPEIQGPVLAAAL 161


                  ..
gi 501231696  202 CY 203
Cdd:pfam00528 162 IL 163
PhnE COG3639
ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport ...
 19-147 2.32e-06

ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 442856 [Multi-domain]  Cd Length: 244  Bit Score: 47.00  E-value: 2.32e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501231696  19 GAAQTLAISALGILFATLGGVLYGVLA---TLGNRALNIALQVYLELFRAIPVLVW--LYLVFFGLPIFfalsipsfwCA 93
Cdd:COG3639   52 ALLETLAIALLGTLLGAVLALPLAFLAarnLAPNPWVRLLARRLLNVLRAIPELVWalIFVAAVGLGPF---------AG 122

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 501231696  94 VLVLALWGASEVGEVVRGALRSLPRGQREAGLSIGLAGWQLYGYVLLPQALKRM 147
Cdd:COG3639  123 VLALAIHTIGFLGKLFAEAIEEIDPGPVEALRATGASRLQVIRYGVLPQVLPQF 176
TauC COG0600
ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion ...
 20-144 3.80e-06

ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440365 [Multi-domain]  Cd Length: 254  Bit Score: 46.29  E-value: 3.80e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501231696  20 AAQTLAISALGILFATLGGVLYGVLATLgNRALNIALQVYLELFRAIPVLVWLYLVFFGLPIFFALSI-PSFWCAVLVLA 98
Cdd:COG0600   63 LLASLLRVLLGFALAALLGVPLGLLLGL-SRLLRRLLDPLLVFLRPIPPLALAPLLILWFGIGEASKIfVIFLGAFFPIL 141

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 501231696  99 LwgasevgeVVRGALRSLPRGQREAGLSIGLAGWQLYGYVLLPQAL 144
Cdd:COG0600  142 L--------NTAAGVRSVDPELLELARSLGASRWQILRKVVLPAAL 179
PhnE TIGR01097
phosphonate ABC transporter, permease protein PhnE; Phosphonates are a class of compound ...
 19-148 2.00e-04

phosphonate ABC transporter, permease protein PhnE; Phosphonates are a class of compound analogous to organic phosphates, but in which the C-O-P linkage is replaced by a direct, stable C-P bond. Some bacteria can utilize phosphonates as a source of phosphorus. This family consists of permease proteins of known or predicted phosphonate ABC transporters. Often this protein is found as a duplicated pair, occasionally as a fused pair. Certain "second" copies score in between the trusted and noise cutoff and should be considered true hits (by context). [Transport and binding proteins, Anions]


Pssm-ID: 273441 [Multi-domain]  Cd Length: 250  Bit Score: 40.99  E-value: 2.00e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501231696   19 GAAQTLAISALGILFATLGGVLYGVLA---TLGNRALNIALQVYLELFRAIPVLVW--LYLVFFGLPIFfalsipsfwCA 93
Cdd:TIGR01097  59 ALLETLAMAILGTVLAAVLAVPLALLAarnITPSPWLYGLARLLLNFLRAIPELVWalIFVAAVGLGPF---------AG 129

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 501231696   94 VLVLALWGASEVGEVVRGALRSLPRGQREAGLSIGLAGWQLYGYVLLPQALKRMT 148
Cdd:TIGR01097 130 VLALAFHTVGFLGKLFAEAIEEVDPGPVEALRATGASKLQVIRYGVLPQVLPQFL 184
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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