|
Name |
Accession |
Description |
Interval |
E-value |
| PTR2 |
COG3104 |
Dipeptide/tripeptide permease [Amino acid transport and metabolism]; |
6-437 |
3.27e-112 |
|
Dipeptide/tripeptide permease [Amino acid transport and metabolism];
Pssm-ID: 442338 [Multi-domain] Cd Length: 479 Bit Score: 338.71 E-value: 3.27e-112
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 6 KRPFGFYVCSLAFTLERFAFYSAKWLIAVFVVAKVAEGGLGLTAADAAKMSANLVAFTYLAPVIGAFISDRLIGARYLVP 85
Cdd:COG3104 11 GHPKGLYTLFFTEMWERFSFYGMRAILVLYLTASLADGGLGLSEADAAAIYGAYTALVYLTPLLGGWLADRLLGQRRAIL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 86 IGMTLMGAGYLVGWQASSAGMVNLMIVLVSLGTGLFKCQTSAITGRLF--DDPRqLDSAFSIQYSFVNIGSFIGTTIIGV 163
Cdd:COG3104 91 LGGILMALGHFLLALPGGVTLFYLGLALIAVGNGLFKPNISSLVGQLYdpGDPR-RDAGFTIFYMGINIGAFLAPLLCGY 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 164 LVGTKGYAFCFLVCGIMMFIDAAWFIFGWKFLGETGKKPFKIDEHKEEKQVK---------------------------- 215
Cdd:COG3104 170 LGEKYGWHYGFGAAAIGMLIGLIIFLLGRKYLGDIGLEPDNPLSKKERLIAValgalllvlvlagllsnanianyllyvi 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 216 ------ETEEEKKPLTTMEKKRVGAIILVSFFSVIFWLFWYLAYMPVYFYWggdNAAANWMIGNFQVPTAWFDSLNALAC 289
Cdd:COG3104 250 aiiayfIFILRSKKLTKEERKRLLAILILFLFSIVFWALYEQAGTSLNLFA---DRNVDRSLFGFEIPPSWFQSLNPLFI 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 290 ISLGPILGKVWEKLAKRpQGDLSMFKKTALGMMLLGLSYVIFAMADVTRG-GNLASIAWIIAFGIVLSLGEMVFSPLGNS 368
Cdd:COG3104 327 IILAPVFAALWTKLGKR-GKEPSTPTKFALGLLLLGLGFLVMALAALLAGaGGKVSPLWLVLAYLLLTIGELCLSPVGLS 405
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 501309448 369 FISKFSPPRLLSVMMSVWILAVFFAAKSYGWVYEFTLKFKFAPTYFVIAAIAAGAGIILWLLDGKLNSL 437
Cdd:COG3104 406 MITKLAPARFAGQMMGLWFLATALGNLLAGLLAGLYAVPGYTAYFLLLGGIALVAGVVLLLLSPKLRRL 474
|
|
| MFS_DtpA_like |
cd17346 |
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily ... |
8-404 |
1.19e-102 |
|
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily of transporters; The DtpA-like subfamily includes four Escherichia coli proteins: dipeptide and tripeptide permeases A (DtpA, TppB or YdgR), B (DtpB or YhiP), C (DtpC or YjdL), and D (DtpD or YbgH). They are proton-dependent permeases that transport di- and tripeptides. DtpA and DtpB display a preference for di- and tripeptides composed of L-amino acids. DtpC shows higher specificity for dipeptides compared to tripeptides, and prefers dipeptides containing a C-terminal lysine residue. The DtpA-like subfamily belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340904 [Multi-domain] Cd Length: 399 Bit Score: 311.43 E-value: 1.19e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 8 PFGFYVCSLAFTLERFAFYSAKWLIAVFVVAKVaegGLGLTAADAAKMSANLVAFTYLAPVIGAFISDRLIGARYLVPIG 87
Cdd:cd17346 1 PKGLYTLFFTEMWERFSYYGMRAILILYLTAQL---GDGFSEADAASIYGAYTALVYLTPIIGGWLADKVLGARRTVFIG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 88 MTLMGAGYLV-GWQASSAGMVNLMIVLVSLGTGLFKCQTSAITGRLFD--DPRqLDSAFSIQYSFVNIGSFIGTTIIGVL 164
Cdd:cd17346 78 GILMALGYLLlALSPFSVSMLYLGLALIIVGNGLFKPNISSLVGKLYDenDPR-RDSGFSIFYMGINLGAFLAPLLCGTL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 165 VGTKGYAFCFLVCGIMMFIDAAWFIFGWKFLgetgkkpfkidehkeekqvketeeekkplttMEKKRVGAIILVSFFSVI 244
Cdd:cd17346 157 GDNYGYHYGFGLAAVGMLLGLLIFLLGRKKL-------------------------------LERKKMLAIIILFLFAVV 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 245 FWLFWYLAYMPVYFYWGGDnaaANWMIGNFQVPTAWFDSLNALACISLGPILGKVWEKLAKRpQGDLSMFKKTALGMMLL 324
Cdd:cd17346 206 FWAIYEQAGTSLALFADEN---VDRLLGGFTIPPSWFQSLNPLFIILLAPILAALWTKLGKR-GKDPSIPTKFALGLLLL 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 325 GLSYVIFAMADVTRGGN-LASIAWIIAFGIVLSLGEMVFSPLGNSFISKFSPPRLLSVMMSVWILAVFFAAKSYGWVYEF 403
Cdd:cd17346 282 GLSFLLMVLAASFAGGSgKVSALWLVLSYFLQTLGELCLSPVGLSMITKLAPAKFAGFMMGLWFLASALGNILAGYLAGF 361
|
.
gi 501309448 404 T 404
Cdd:cd17346 362 Y 362
|
|
| yjdL_sub1_fam |
TIGR00924 |
amino acid/peptide transporter (Peptide:H+ symporter), bacterial; The model describes ... |
8-404 |
1.61e-40 |
|
amino acid/peptide transporter (Peptide:H+ symporter), bacterial; The model describes proton-dependent oligopeptide transporters in bacteria. This model is restricted in its range in recognizing bacterial proton-dependent oligopeptide transporters, although they are found in yeast, plants and animals. They function by proton symport in a 1:1 stoichiometry, which is variable in different species. All of them are predicted to contain 12 transmembrane domains, for which limited experimental evidence exists. [Transport and binding proteins, Amino acids, peptides and amines]
Pssm-ID: 273342 [Multi-domain] Cd Length: 475 Bit Score: 150.76 E-value: 1.61e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 8 PFGFYVCSLAFTLERFAFYSAKWLIAVFVVAkvaEGGLGLTAADAAKMSANLVAFTYLAPVIGAFISDRLIGARYLVPIG 87
Cdd:TIGR00924 9 PKPLFTLFFVELWERFSYYGMQGILAVYLVQ---QAGLGFSQEQAFIIFGAYSALVYLLTSVGWWFGDRVWGTKKTMVLG 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 88 MTLMGAGYLVGWQASSAGMVNLMIVLVSLGTGLFKCQTSAITGRLF---DDPRqLDSAFSIQYSFVNIGSFIGTTIIGVL 164
Cdd:TIGR00924 86 GIVLMLGHFMLAMSIYPDLIFYGLGTIAVGSGLFKANPSSMVGKLYergDMPR-RDGGFTLFYMSINIGSFISPLLAGVI 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 165 VGTKGYAFCFLVCGIMMFIDAAWFIFGWKFLGETGKKPFKID-EHKEEKQVKET-------------------------- 217
Cdd:TIGR00924 165 AENYGYHVGFNLAAVGMVIGLLTFFAGRHMLRDIGSVPDPLSgQGKTYGKLLLAllaalalvffcawlmhhvvianillm 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 218 ------------EEEKKPLTTMEKKRVGAIILVSFFSVIFWLFWYLAYMPVYFYwgGDNAAANWMIGnFQVPTAWFDSLN 285
Cdd:TIGR00924 245 tvtlaviifffrLAFKPRLDAVARNKMYAYIVLFLEAVVFWVLYAQMPTSLNFF--ADNNMHHEMLG-MSVPVIWFQSLN 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 286 ALACISLGPILGKVWEKLAKRPQgDLSMFKKTALGMMLLGLSYVIF-AMADVTRGGNLASIAWIIAFGIVLSLGEMVFSP 364
Cdd:TIGR00924 322 PFWVVVGSPVLAMIWTRLGRKGK-DPTTPLKFTLGMLFCGASFLTFaASIWFADAGGLTSPWFMVLIYLFQTLGELMISP 400
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 501309448 365 LGNSFISKFSPPRLLSVMMSVWILAVFFAAKSYGWVYEFT 404
Cdd:TIGR00924 401 LGLSWWTKIAPQRLMGQMLGMWFLAQAMGSLLGGYLATFG 440
|
|
| PTR2 |
pfam00854 |
POT family; The POT (proton-dependent oligopeptide transport) family all appear to be proton ... |
111-388 |
1.80e-29 |
|
POT family; The POT (proton-dependent oligopeptide transport) family all appear to be proton dependent transporters.
Pssm-ID: 425909 [Multi-domain] Cd Length: 392 Bit Score: 118.58 E-value: 1.80e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 111 IVLVSLGTGLFKCQTSAITGRLFD--DPRQLDSAFSIQYSFVNIGSFIGTTIIGVLVGTKGYAFCFLVCGIMMFIDAAWF 188
Cdd:pfam00854 39 LALIALGTGGIKPNVSSFGGDQFEetDPRRRSRFFSIFYFSINAGSLISTIITPYLQQNYGYPLGFGLPAVGMIIALLVF 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 189 IFGWKFLGETGKKP--------------------------FKIDEHKE---EKQVKETEEEKKPLTT----------MEK 229
Cdd:pfam00854 119 LLGSRMYKKKPPKGnvltkvfkvlpvaawnkvklngssagIKKLHWLDwarELDALIILGIVVPGIFfniwctktkvEEV 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 230 KRVGAIILVSFFSVIFWLFWylAYMPVYFywggdNAAANWM---IGNFQVPTAWFDSLNALACISLGPILGKVWEKLAKR 306
Cdd:pfam00854 199 KRLLRVLPLFLPLIMFWALY--DQMGTSW-----VLQARTMnrkIGSFEIPPAQFQAFNAILVLIFIPIFDRLVYPLGRK 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 307 PQGDLSMFKKTALGMMLLGLSYVIFAMADVTR----------GGNLASIAWIIAFGIVLSLGEMVFSPLGNSFISKFSPP 376
Cdd:pfam00854 272 CTGGLTPLQKMAVGLFLASLAFAIAAIVQLKRndtgpefpiaQEVPISVLWLIPQYLLIGFGELFISIGGLEFFYKLAPK 351
|
330
....*....|..
gi 501309448 377 RLLSVMMSVWIL 388
Cdd:pfam00854 352 SMTSLITGLFLL 363
|
|
| tppB |
PRK09584 |
dipeptide/tripeptide permease DtpA; |
3-400 |
8.40e-26 |
|
dipeptide/tripeptide permease DtpA;
Pssm-ID: 181969 Cd Length: 500 Bit Score: 109.46 E-value: 8.40e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 3 NTNKRPFGFYvcsLAFTLE---RFAFYSAKWLIAVFVVAKvaeggLGLTAADAAKMSANLVAFTYLAPVIGAFISDRLIG 79
Cdd:PRK09584 15 NAFKQPKAFY---LIFSIElweRFGYYGLQGIMAVYLVKQ-----LGMSEADSITLFSSFSALVYGLVAIGGWLGDKVLG 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 80 ARYLVPIGMTLMGAGY-LVGWQASSAGMVNLMIVLVSLGTGLFKCQTSAITGRLF--DDPRqLDSAFSIQYSFVNIGSFI 156
Cdd:PRK09584 87 TKRVIMLGAIVLAIGYaLVAWSGHDAGIVYMGMATIAVGNGLFKANPSSLLSTCYekDDPR-LDGAFTMYYMSINIGSFF 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 157 GTTIIGVLVGTKGYAFCFLVCGIMMFIDAAWFIFGWKFLGETGKKPFKIDEHKeekqvketeeeKKPLTTMekkrVGAII 236
Cdd:PRK09584 166 SMLATPWLAAKYGWSVAFALSVVGMLITVVNFAFCQRWVKQYGSKPDFEPINY-----------RKLLLTI----VGVVA 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 237 LVSFFSVIF-------WLFWYLAYMPVYFY----WGGDNAAANWMIGNF--------------QVPTAW----------- 280
Cdd:PRK09584 231 LIAIATWLLhnqeiarMALGVVALGIVVIFgkeaFAMKGAARRKMIVAFilmleaiiffvlysQMPTSLnffairnvehs 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 281 ----------FDSLNALACISLGPILGKVWEKLAKRpqgdLSMFKKTALGMMLLGLSYVIFAM-ADVTRGGNLASIAWII 349
Cdd:PRK09584 311 ilgiavepeqYQALNPFWIMIGSPILAAIYNKMGDR----LPMPHKFAIGMVLCSGAFLVLPLgAKFANDAGIVSVNWLI 386
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|.
gi 501309448 350 AFGIVLSLGEMVFSPLGNSFISKFSPPRLLSVMMSVWILAVFFAAKSYGWV 400
Cdd:PRK09584 387 ASYGLQSIGELMISGLGLAMVAQLVPQRLMGFIMGSWFLTTAGAALIAGYV 437
|
|
| MFS_POT |
cd06175 |
Proton-coupled oligopeptide transporter (POT) family of the Major Facilitator Superfamily of ... |
20-392 |
2.57e-19 |
|
Proton-coupled oligopeptide transporter (POT) family of the Major Facilitator Superfamily of transporters; The Proton-coupled oligopeptide transporter (POT) family is present across all major kingdoms of life and is known by a variety of names. It is referred to as the Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) in plants, and in addition to POT, it is also known as the Peptide transporter (PepT/PTR) or Solute Carrier 15 (SLC15) family in animals. Members of this family are proton-driven symporters involved in nitrogen acquisition in the form of di- and tripeptides. Plant members transport other nitrogenous ligands including nitrate, the plant hormone auxin, and glucosinolate compounds that are important for seed defense. POT proteins exhibit substrate multispecificity, with one transporter able to recognize as many as 8,400 types of di/tripeptides and certain peptide-like drugs. The POT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340865 [Multi-domain] Cd Length: 422 Bit Score: 89.80 E-value: 2.57e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 20 LERFAFYSAKWLIAVFVvakvaEGGLGLTAADAAKMSANLVAFTYLAPVIGAFISDRLIGARYLVPIGMTLMGAGYLV-- 97
Cdd:cd06175 10 CERFTFYGIGANLVPFL-----TGALGLGNAQAANVVLNFLGTSYVTPLFGGWIADTFLGRYRTILIGAAIYAVGVAIlt 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 98 ----------------GWQASSAGMVNLM---IVLVSLGTGLFKCQTSAITGRLFD--DPRQLDSAFSIQYSFVNIGSFI 156
Cdd:cd06175 85 vstippglrplrcnpsHCEQASGIQLTGFyaaLYLIALGTGGVKANVSPLGADQFDerGPSKTQSFFNWFYFCINVGSLL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 157 GTTIIGVLVGTKGYAFCFLVCGIMMFIdaawfifgwkflgetgkkpfkidehkeekqvketeeekkPLTTMEKKRVGAII 236
Cdd:cd06175 165 AMLGTPYIQDNVGWAAAYGIPFVAILL---------------------------------------ALVVFEVKQLLRAL 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 237 LVSFFSVIFWLFWylAYMPVYFYWGGDNAAANwmIGNFQVPTAWFDSLNALACISLGPILGKVWEKLAKRPQGDLSMFKK 316
Cdd:cd06175 206 PLFAFCILFWTVY--AQMTTSYVLQALTLVRS--TGLFTIPPASMQAFNPILLLLLIPVLDKVVYPLIRRYGVGLSPLTK 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 317 TALGMMLLGLSYVIFAMAD-----------VTRGGNLASIAWIIAFGIVLSLGEMVFSPLGNSFISKFSPPRLLSVMMSV 385
Cdd:cd06175 282 IGLGFFFGSLSMFVAGFLElkrlntahahgPVVTTSPLSFWWQIPQYLLLGIGEILVSITGLEFAYREAPKSMKGFIMGL 361
|
....*..
gi 501309448 386 WILAVFF 392
Cdd:cd06175 362 LLLTSGF 368
|
|
| PRK15462 |
PRK15462 |
dipeptide permease; |
1-388 |
1.20e-18 |
|
dipeptide permease;
Pssm-ID: 237971 [Multi-domain] Cd Length: 493 Bit Score: 88.08 E-value: 1.20e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 1 MENTNKRPFGFYVCSLAFTLERFAFYSAKWLIAVFVVAKvaeggLGLTAADAAKMSANLVAFTYLAPVIGAFISDRLIGA 80
Cdd:PRK15462 1 MNKHASQPRAIYYVVALQIWEYFSFYGMRALLILYLTNQ-----LKYDDNHAYELFSAYCSLVYVTPILGGFLADKVLGN 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 81 RYLVPIGMTLMGAGYLV-GWQASSAGMVNLMIVLVSLGTGLFKCQTSAITGRLF--DDPRQlDSAFSIQYSFVNIGSFIG 157
Cdd:PRK15462 76 RMAVMLGALLMAIGHVVlGASEIHPSFLYLSLAIIVCGYGLFKSNVSCLLGELYepTDPRR-DGGFSLMYAAGNVGSIIA 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 158 TTIIGVLVGTKGYAFCFLVCGIMMFIDAAWFIFGWKFLGETG-------------------------KKPFKI-----DE 207
Cdd:PRK15462 155 PIACGYAQEEYSWAMGFGLAAVGMIAGLVIFLCGNRHFTHTRgvnkkvlratnfllpnwgwllvllvATPALItvlfwKE 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 208 HKEEKQVKET--------EEEKKPLTTMEKKRVGAIILVSFFSVIFWLFWYLAYMPVYFYWggdNAAANWMIGNFQVPTA 279
Cdd:PRK15462 235 WSVYALIVATiiglgvlaKIYRKAENQKQRKELGLIVTLTFFSMLFWAFAQQGGSSISLYI---DRFVNRDMFGYTVPTA 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 280 WFDSLNALACISLGPILGkvWekLAKRPQG---DLSMFKKTALGMMLLGLSYVIFAM-ADVTRGGNLASIAWIIAFGIVL 355
Cdd:PRK15462 312 MFQSINAFAVMLCGVFLA--W--VVKESVAgnrTVRIWGKFALGLGLMSAGFCILTLsARWSAMYGHSSLPLMVLGLAVM 387
|
410 420 430
....*....|....*....|....*....|...
gi 501309448 356 SLGEMVFSPLGNSFISKFSPPRLLSVMMSVWIL 388
Cdd:PRK15462 388 GFAELFIDPVAMSQITRIEIPGVTGVLTGIYML 420
|
|
| MFS_SLC15A1_2_like |
cd17347 |
Solute carrier family 15 members 1 and 2, and similar Major Facilitator Superfamily ... |
21-392 |
9.94e-18 |
|
Solute carrier family 15 members 1 and 2, and similar Major Facilitator Superfamily transporters; Solute carrier family 15 member 1 (SLC15A1) and SLC15A2 are members of the proton-coupled oligopeptide transporter (POT) family of integral membrane proteins that mediate the cellular uptake of di/tripeptides and peptide-like drugs. They mediate the proton-coupled active transport of a broad range of dipeptides and tripeptides, including zwitterionic, anionic and cationic peptides, as well as a variety of peptide-like drugs such as cefadroxil, enalapril, and valacyclovir. SLC15A1, or peptide transporter 1 (PepT1), is primarily expressed in the brush border membranes of enterocytes of the small intestine and is also known as the intestinal isoform. SLC15A2, or peptide transporter 2 (PepT2), is abundantly expressed in the apical membrane of kidney proximal tubules and is also referred to as the renal isoform. Both proteins transport di/tripeptides, but not tetrapeptides or free amino acids, using the energy generated by an inwardly directed transmembrane proton gradient. The SLC15A1/SLC15A2-like group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340905 [Multi-domain] Cd Length: 427 Bit Score: 84.98 E-value: 9.94e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 21 ERFAFYSAKWLIAVFVVAKvaeggLGLTAADAAKMSANLVAFTYLAPVIGAFISDRLIGaRYLVPIGMTLMgagYLVGWQ 100
Cdd:cd17347 14 ERFSYYGMRAILVLYLTDF-----LGFSEAEATAIYHSFVMLCYFFPLLGAIIADSYLG-KYRTILYLSLV---YCLGHI 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 101 ASSAGMVNLMIV-----------LVSLGTGLFKCQTSAITGRLFDDP--RQLDSAFSIQYSFVNIGSFIGTTIIGVL--- 164
Cdd:cd17347 85 VLAVTAIPPLGPphvwglligllLIAIGTGGIKPCVSAFGGDQFGADqqHLLARFFSWFYFAINAGSLLSTFLTPILrad 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 165 ---VGTKGYAFCFLVCGIMMFIDAAWFIFGWKFLGETgkkpfkidehkeekqvketeeekkplttmekKRVGAIILVSFF 241
Cdd:cd17347 165 vqfGGHDCYPLAFGVPGVLMAVATLVFWLGRKHYKDV-------------------------------KALLRVLVLFIP 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 242 SVIFW-LF------WYLAYmpvyfywggdnAAANWMIGNFQVPTAWFDSLNALACISLGPILGKVWEKLAKRPQGDLSMF 314
Cdd:cd17347 214 LPVFWaLFdqqgsrWTLQA-----------EQMDGLVGGFTILPDQMQALNPILILILIPLFDYVIYPLLERCGIPLTPL 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 315 KKTALGMMLLGLSYVIFA--------MADVTRGGNLA-----------SIAWIIAFGIVLSLGEMVFSPLGNSFISKFSP 375
Cdd:cd17347 283 RKMGVGMILAALAFVIAGflqlridgGLPGQPDPGEVttfediepnsvSILWQLPQYVVLTAGEVLFSITGLEFAYTQAP 362
|
410
....*....|....*..
gi 501309448 376 PRLLSVMMSVWILAVFF 392
Cdd:cd17347 363 KSMKSVVQAAWLLTVAL 379
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
44-403 |
1.31e-16 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 81.12 E-value: 1.31e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 44 GLGLTAADAAKMSANLVAFtyLAPVIGAFISDRlIGARYLVPIGMTLMGAGYLVGWQASSAGMVNLMIVLVSLGTGLFKC 123
Cdd:cd17329 31 GLSASIVGLVLALSAVAGI--VASLIGGRLADR-FGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEP 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 124 QTSAITGRLFDdPRQLDSAFSIQYSFVNIGSFIGTTIIGVLVGTkGYAFCFLVCGIMMFIDAAWFIFgwkflgetgkkpf 203
Cdd:cd17329 108 ASEAMIADVTT-PENRTRAFSLLYWAINLGVAIGPLLGGLLLLY-SFRLLFLAAAVLFLLAALVLLF------------- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 204 KIDEHKEEKQVKETEEEKKPLTTmeKKRVGAIILVSFFSVIFWL--FWYLAYMPVYfywggdnaaANWMIGNFQVPTAWF 281
Cdd:cd17329 173 LLPETRPKRRAAEKTEILRGYKI--VLRDRAFLLFLLASFLISLiyFQLESTLPVY---------VVEILGLGESLLGLL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 282 DSLNALACISLGPILGKVWEKLAKRPQGdlsmfkktALGMMLLGLSYVIFAMAdvtrggnlASIAWIIAFGIVLSLGEMV 361
Cdd:cd17329 242 LALNALLIVLLQFPVARLVERFRLRKIL--------MIGILLFAIGFAVLAFA--------NTLAVLILAMIVLTLGEML 305
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 501309448 362 FSPLGNSFISKFSPPRLL----SVMMSVWILAVFFAAKSYGWVYEF 403
Cdd:cd17329 306 VFPAVQTLVAALAPPDKRgsymGFYALAWGLGRAIGPLVGGLLLDL 351
|
|
| PRK10207 |
PRK10207 |
dipeptide/tripeptide permease DtpB; |
6-404 |
1.35e-15 |
|
dipeptide/tripeptide permease DtpB;
Pssm-ID: 182306 Cd Length: 489 Bit Score: 78.71 E-value: 1.35e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 6 KRPFGFYVCSLAFTLERFAFYSAKWLIAVFVVAKvaeggLGLTAADAAKMSANLVAFTYLAPVIGAFISDRLIGARYLVP 85
Cdd:PRK10207 11 QQPRPFFMIFFVELWERFGYYGVQGILAVFFVKQ-----LGFSQEQAFITFGAFAALVYGLISIGGYVGDHLLGTKRTIV 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 86 IGMTLMGAGY-LVGWQASSAGMVNLMIVLVSLGTGLFKCQTSAITGRLF--DDPRqLDSAFSIQYSFVNIGSFIGTTIIG 162
Cdd:PRK10207 86 LGAIVLAIGYfMTGMSLLKPDLIFIALGTIAVGNGLFKANPASLLSKCYppKDPR-LDGAFTLFYMSINIGSLISLSLAP 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 163 VLVGTKGYAFCFLVCGIMMFIDAAWFIFGWKFLGETGKKPfkidEHKEEKQVKETEEEKKPLTT-------MEKKRVGAI 235
Cdd:PRK10207 165 VIADKFGYSVTYNLCGAGLIIALLVYFACRGMVKDIGSEP----DHKPMSFSKLLLVLLGSVVMifvcawlMHNVEVANL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 236 ILVSFFSVIFWLFWYLAY-----------------------------MPVYFYWGGDNAAANWMIGnFQVPTAWFDSLNA 286
Cdd:PRK10207 241 VLIVLSIVVTIIFFREAFkldktgrnkmfvafvlmleavvfyilyaqMPTSLNFFAINNVHHEILG-FSINPVSFQALNP 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 287 LACISLGPILGKVWEKLAKRPQgDLSMFKKTALGMMLLGLSYVIFAMADV--TRGGNLASIAWIIAFGIVLSLGEMVFSP 364
Cdd:PRK10207 320 FWVVVASPILAGIYTHLGSKGK-DLSMPMKFTLGMFLCSLGFLTAAAAGMwfADAQGLTSPWFIVLVYLFQSLGELFISA 398
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 501309448 365 LGNSFISKFSPPRLLSVMMSVWILAVFFAAKSYGWVYEFT 404
Cdd:PRK10207 399 LGLAMIAALVPQHLMGFILGMWFLTQAAAFLLGGYVATFT 438
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
7-395 |
1.75e-13 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 71.16 E-value: 1.75e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 7 RPFGFYVCSLAFTLERFAFYsakwLIAVFVVAKVAEGGLGLTAADAAkMSANLVAFTYLAPVIGAfISDRlIGARYLVPI 86
Cdd:COG2814 8 RWLALLALALGAFLSGLGIG----IVLPALPLIAADLGASPAQAGLV-VTAYLLGAALGAPLAGR-LADR-FGRRRVLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 87 GMTLMGAGYLVGWQASSAGMVNLMIVLVSLGTGLFKCQTSAITGRLFDdPRQLDSAFSIQYSFVNIGSFIGTTIIGVLVG 166
Cdd:COG2814 81 GLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVP-PERRGRALGLLGAGLGLGPALGPLLGGLLAD 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 167 TKGYAFCFLVCGIMMFIDAAWFIFGWKflgetgkkpfkidehkeEKQVKETEEEKKPLTTMEKKRVGAIILVSFFSVIFW 246
Cdd:COG2814 160 LFGWRWVFLVNAVLALLALLLLLRLLP-----------------ESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFG 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 247 LFWYLAYMPVYF--YWGGDNAAANWMIGnfqvptawfdsLNALACISLGPILGkvweKLAKRpqgdLSMFKKTALGMMLL 324
Cdd:COG2814 223 FFALFTYLPLYLqeVLGLSASAAGLLLA-----------LFGLGGVLGALLAG----RLADR----FGRRRLLLIGLLLL 283
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 501309448 325 GLSYVIFAMADvtrggnlaSIAWIIAFGIVLSLGEMVFSPLGNSFISKFSPPRLLSVMMSVWILAVFFAAK 395
Cdd:COG2814 284 ALGLLLLALAG--------SLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGP 346
|
|
| MFS_SLC15A1 |
cd17412 |
Solute Carrier family 15 member 1 of the Major Facilitator Superfamily of transporters; Solute ... |
59-390 |
8.75e-12 |
|
Solute Carrier family 15 member 1 of the Major Facilitator Superfamily of transporters; Solute carrier family 15 member 1 (SLC15A1), also called peptide transporter 1 (PepT1), is a member of the proton-coupled oligopeptide transporter (POT) family of integral membrane proteins that mediate the cellular uptake of di/tripeptides and peptide-like drugs. SLC15A1, as well as SLC15A2, mediate the proton-coupled active transport of a broad range of dipeptides and tripeptides, including zwitterionic, anionic and cationic peptides, as well as a variety of peptide-like drugs such as cefadroxil, enalapril, and valacyclovir. SLC15A1 is primarily expressed in the brush border membranes of enterocytes of the small intestine and is also known as the intestinal isoform. It is a high-capacity/low-affinity transporter that drives the transport of di-and tripeptides for metabolic purposes. It's expression is upregulated in the colon during chronic inflammation associated with inflammatory bowel disease. SLC15A1/PepT1 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340970 [Multi-domain] Cd Length: 415 Bit Score: 66.41 E-value: 8.75e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 59 LVAFTYLAPVIGAFISDRLIGaRYLVPIGMTLMgagYLVGWQASSAGMVNLM----------------------IVLVSL 116
Cdd:cd17412 47 FVALCYLTPILGAIIADSWLG-KFKTIVYLSIV---YTIGQAVMAVSAIHDLtdanrdgtpdnltlhvalsmigLLLIAL 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 117 GTGLFKCQTSAITGRLFDD--PRQLDSAFSIQYSFVNIGSFIGTTIIGVLVGT--------KGYAFCFLVCGIMMFIDAA 186
Cdd:cd17412 123 GTGGIKPCVAAFGGDQFEEhqEKQRSRFFSIFYLSINAGSLLSTIITPILRSQecgihskqKCYPLAFGVPAALMVVALI 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 187 WFIFGwkflgetgkkpfkideHKEEKQVKeteeekkplttmekkrvgAIILVSFFSVIFWLFWYLAympvyfywggDNAA 266
Cdd:cd17412 203 VFILG----------------SKMYKQIK------------------MVLKVLFLYIPLPMFWALF----------DQQG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 267 ANW------MIGNF---QVPTAWFDSLNALACISLGPILGKVWEKLAKRPQGDLSMFKKTALGMMLLGLSYVIFAMADVt 337
Cdd:cd17412 239 SRWtlqattMDGNFgaiQIQPDQMQTVNPILIIIMVPIFDAVIYPLIKKCKINFTPLRKMTVGMFLAALAFVAAALLQI- 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 501309448 338 rggnlaSIAWIIAFGIVLSLGEMVFSPLGNSFISKFSPPRLLSVMMSVWILAV 390
Cdd:cd17412 318 ------QMAWQIPQYFLLTCGEVVFSVTGLEFSYSQAPSNMKSVLQAGWLLTV 364
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
23-394 |
5.74e-11 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 63.59 E-value: 5.74e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 23 FAFYSAKWLIAVFVVAKVAEGgLGLTAADAAKMSANLVAFTYLAPVIGAFISDRlIGARYLVPIGMTLMGAGYLVGWQAS 102
Cdd:pfam07690 6 FLAALGRSLLGPALPLLLAED-LGISPTEIGLLLTLFSLGYALAQPLAGRLSDR-FGRRRVLLIGLLLFALGLLLLLFAS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 103 SAGMVNLMIVLVSLGTGLFKCQTSAITGRLFDdPRQLDSAFSIQYSFVNIGSFIGTTIIGVLVGTKGYAFCFLVCGIMMF 182
Cdd:pfam07690 84 SLWLLLVLRVLQGLGAGALFPAALALIADWFP-PEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 183 IdaaWFIFGWkflgetgkkpFKIDEHKEEKQVKETEEEKKPLTTMEKKRVGAIILVSFFSVIFWLFWYLAYMPVYFYWGG 262
Cdd:pfam07690 163 L---AAVLLL----------LPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEV 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 263 DNAAANWMIGNFqvptawfdSLNALACISLGPILGKVWEKLAKRPqgdlsmfkktalgMMLLGLSYVIFAMADVTRGGNL 342
Cdd:pfam07690 230 LGLSALLAGLLL--------GLGGLLGAIGRLLLGRLSDRLGRRR-------------RLLLALLLLILAALGLLLLSLT 288
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 501309448 343 ASIAWIIAFGIVLSLGEMVFSPLGNSFISKFSPPRLLSVMMSVWILAVFFAA 394
Cdd:pfam07690 289 LSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGG 340
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
8-193 |
7.20e-10 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 60.27 E-value: 7.20e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 8 PFGFYVCSLAFtlerFAFYSAKWLIAVFVVAkVAEGGLGLTAADAAKMSANLVAFTYLAPVIGAFISDRLI-GARYLVPI 86
Cdd:COG2271 179 LLRFWLLALAY----FLVYFALYGFLTWLPT-YLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGrRRKLVLAI 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 87 GMTLMGAGYLVGWQASSAGMVNLMIVLVSLGTGLFKCQTSAITGRLFDdPRQLDSAFSIQYSFVNIGSFIGTTIIGVLVG 166
Cdd:COG2271 254 GLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFP-KKARGTASGLVNTFGFLGGALGPLLVGYLLD 332
|
170 180
....*....|....*....|....*..
gi 501309448 167 TKGYAFCFLVCGIMMFIDAAWFIFGWK 193
Cdd:COG2271 333 ATGYQAAFLLLAALALLAALLALLLLR 359
|
|
| MFS_NPF |
cd17351 |
Plant NRT1/PTR family (NPF) of the Major Facilitator Superfamily of transporters; The plant ... |
19-198 |
8.43e-10 |
|
Plant NRT1/PTR family (NPF) of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340909 [Multi-domain] Cd Length: 445 Bit Score: 60.33 E-value: 8.43e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 19 TLERFAFYSakwlIAVFVVAKVAeGGLGLTAADAAKMSANLVAFTYLAPVIGAFISDRLIGaRYLVPIGMTLMgagYLVG 98
Cdd:cd17351 9 FAERLAFYG----IAVNLVTYLT-KVMHLSNAKAANTVTNFSGTSYLTPLLGAFLADAYLG-RYWTIAIFSVI---YLVG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 99 W------------------------QASSAGMVNLMIVL--VSLGTGLFKCQTSAITGRLFDD-----PRQLDSAFSIQY 147
Cdd:cd17351 80 LilltlsasvpslrpppcnpdspcePASSTQLTVLYVGLylIALGTGGIKPCVSAFGADQFDEtdpkeKKQKPSFFNWFY 159
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 501309448 148 SFVNIGSFIGTTIIGVLVGTKGYAFCFLVCGIMMFIDAAWFIFGWKFLGET 198
Cdd:cd17351 160 FSINLGSLLAVTLVVYIQDNVSWGWGFGIPAAAMALAVIVFVAGTPFYREV 210
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
55-393 |
6.55e-08 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 54.54 E-value: 6.55e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 55 MSANLVAFTYLAPVIGAFIsDRLiGARYLVPIGMTLMGAGYLVGWQASSAGMVNLMIVLV-----SLGTGLFKCQTSAIT 129
Cdd:cd06173 40 LAAFFLPFLLFSPFAGVLA-DRF-DRRRLLILADLLRALLAAVLALLALLGSLSLWLLLVlafllGIASAFFGPARQALL 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 130 GRLFDdPRQLDSAFSIQYSFVNIGSFIGTTIIGVLVGTKGYAFCFLVCGIMMFIdAAWFIFGWKFlgetgkKPFKIDEHK 209
Cdd:cd06173 118 PELVP-KEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLL-SALLLLFIRR------PPPAAPGES 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 210 EEKQVKETEEEKKpLTTMEKKRVGAIILVSFFSVIFWLFWYLAYMPVYFYWGGDNAAANWMignfqvptawfdslnaLAC 289
Cdd:cd06173 190 SSLLLRDLREGLR-YLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLL----------------LAA 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 290 ISLGPILGKVwekLAKRPQGDLSMFKKTALGMMLLGLSYVIFAMAdvtrggnlASIAWIIAFGIVLSLGEMVFSPLGNSF 369
Cdd:cd06173 253 FGVGALLGAL---LLGRLSKRRRRGRLLLIGALLLGLALLVLGLS--------PSLWLLLAALFLLGLAGGLFNVPLNTL 321
|
330 340
....*....|....*....|....
gi 501309448 370 ISKFSPPRLLSVMMSVWILAVFFA 393
Cdd:cd06173 322 LQLRVPDELRGRVFSVYNALNSGA 345
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
33-414 |
1.12e-07 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 53.58 E-value: 1.12e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 33 AVFVVAKVAEGGLGLTAADAAKMSANLVAFTYLAPVIGAFISDRlIGARYLVPIGMTLMGAGYLVGWQASSAGMVNLMIV 112
Cdd:cd06174 14 LISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADR-FGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRF 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 113 LVSLGTGLFKCQTSAITGRLFDdPRQLDSAFSIQYSFVNIGSFIGTTIIGVLVGTKGYAFcFLVCGIMMFIDAAWFIFGW 192
Cdd:cd06174 93 LLGLGSGLIDPAVLALIADLFP-ERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGW-RAVFLIAAALALLAAILLL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 193 KFLGETGKkpfkidEHKEEKQVKETEEEKKPLTTMEKKRVGAIILVSFFSVIFWLFWYLAYMPVYFYWGGDNAAANwmig 272
Cdd:cd06174 171 LVVPDPPE------SARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAV---- 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 273 nfqvpTAWFDSLNALACISLGPILGKVWEKLAKRpqgdlsmfkKTALGMMLLGLSYVIFAMADvtrggnLASIAWIIAFG 352
Cdd:cd06174 241 -----AGLLLSLFGLAGALGSLLLGLLSDRLIGR---------KPLLLIGLLLMALGLALLLL------APSLLLLLLLL 300
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 501309448 353 IVLSLGEMVFSPLGNSFISKFSPPRLLSVMMSVWILAVFFAAKSYGWVYEFTLKFKFAPTYF 414
Cdd:cd06174 301 LLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGA 362
|
|
| MFS_NPF7 |
cd17419 |
NRT1/PTR family (NPF), subfamily 7 of the Major Facilitator Superfamily of transporters; The ... |
45-333 |
1.57e-07 |
|
NRT1/PTR family (NPF), subfamily 7 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF7 includes the nitrate transporters AtNPF7.2 and AtNPF7.3, as well as the dipeptide transporter OsNPF7.3. AtNPF7.3 is a bidirectional transporter involved in nitrate influx and efflux. NPF7 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340977 [Multi-domain] Cd Length: 447 Bit Score: 53.53 E-value: 1.57e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 45 LGLTAADAAKMSANLVAFTYLAPVIGAFISDRLIGaRYLVP--------IGMTLM--------------GAGYLVGWQAS 102
Cdd:cd17419 33 MHQSNASAANNVSNWTGTVYITPLIGAFLSDSYWG-RYWTStlfqaifvIGLLLLtlssalpslrppqcGDGDLKCPPAS 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 103 SA--GMVNLMIVLVSLGTGLFKCQTSAITGRLFDD-----PRQLDSAFSIQYSFVNIGSFIGTTIIGVLVGTKGYAFCFL 175
Cdd:cd17419 112 AAqtTFLYFSLYLIALGYGGYQPCIATLGADQFDDedpieKASKSAFFSYFYQALNLGSLFSNTILVYFEDNGSWGLGFG 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 176 VCGIMMFIDAAWFIFGWKFlgetgkkpfkideHKEEKQVketeeekkplttmekKRVGAIILVS-FFSVIFwlfwylAYM 254
Cdd:cd17419 192 ISAGAAFIGLVLFLAGTPF-------------YREVKCI---------------LRLLPIWLSTiIYSVVY------TQM 237
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 501309448 255 PVYFYWGGdnAAANWMIGNFQVPTAWFDSLNALACISLGPILGKVWEKLAKRPQGDLSMFkkTALGMMLLGLSYVIFAM 333
Cdd:cd17419 238 ATLFVEQG--AAMDTSFGNFKIPPASMSVFEILSVAVGTVLYRKFLVPLLRKVTGHPKGI--TELQRMGIGLVIGILAM 312
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
55-191 |
1.62e-07 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 52.96 E-value: 1.62e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 55 MSANLVAFTYLAPVIGAfISDRlIGARYLVPIGMTLMGAGYLVGWQASSAGMVNLMIVLVSLGTGLFKCQTSAITGRLFD 134
Cdd:cd17325 241 FGAQGLASALSQPPAGK-LSDR-IGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVP 318
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 501309448 135 dPRQLDSAFSIQYSFVNIGSFIGTTIIGVLVGTKGYAFCFLVCGIMMFIDAAWFIFG 191
Cdd:cd17325 319 -PEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLL 374
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
53-190 |
3.24e-07 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 52.19 E-value: 3.24e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 53 AKMSANLVAFTYLAPVIGAFISDRL---IGARYLVPIGMTLMGAGYLVGWQASSAGMVNLMIVLVSLGTGL-FKCQTSAI 128
Cdd:cd17473 232 AALIGLALAIASLAGAIGALLFGRLkrrLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLlLPTLNSWA 311
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 501309448 129 TGRLfdDPRQLDSAFSIQYSFVNIGSFIGTTIIGVLV-GTKGYAFCFLVCGIMMFIDAAWFIF 190
Cdd:cd17473 312 MSLV--PPELRGRAMGIVTSAFFLGQFLSPLVLGPLVnLTGGLSGAFLILGVLALVLAIVLLL 372
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
13-404 |
3.72e-07 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 52.19 E-value: 3.72e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 13 VCSLAFTLERFAFYsakwLIAVFVVAKVAEggLGLTAADAAKMSANLVAFTYLAPVIGAFISDRlIGARYLVPIGMTLMG 92
Cdd:COG2223 9 LATLAFFLAFGVWY----LWSVLAPPLAEE--FGLSAAQLGLLFAIPVLVGALLRIPLGFLVDR-FGPRRVLLIGLLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 93 AGYLVGWQASSAGMVNLMIVLVSLGTGLFKCQTSAITGRLFDdPRQLDSAFSIQYSFVNIGSFIGTTIIGVLVGTKGYAF 172
Cdd:COG2223 82 IGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFP-PDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 173 CFLVCGIMMFIdaaWFIFGWKFLgetgkkpfkidehkEEKQVKETEEEKKPLTTmekkrvgaiILVSFFSVIFWLFWYLA 252
Cdd:COG2223 161 AFLILGILLLV---VAVLAWLFL--------------RDPPAGAAAAAKASLRD---------QLEALRDPRFWLLSLLY 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 253 YMPVYFYWGGDNAAANWMIGNFQVPT---AWFDSLNALACISLGPILGKVWEKLAKRpqgdlsmfKKTALGMMLLGLSYV 329
Cdd:COG2223 215 FGTFGSFIGFSSWLPPYLVDQFGLSAataGLLAALFALLGALGRPLGGWLSDRIGGR--------RVLLIVFALMALGLL 286
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 501309448 330 IFAMAdvtrggnLASIAWIIAFGIVLSLGEMVFSPLGNSFISKFSPPRLLSVMMS----VWILAVFFAAKSYGWVYEFT 404
Cdd:COG2223 287 LLALA-------LGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGlvgaAGGLGGFLGPLLFGALLDAT 358
|
|
| MFS_NPF8 |
cd17418 |
NRT1/PTR family (NPF), subfamily 8 of the Major Facilitator Superfamily of transporters; The ... |
21-334 |
4.15e-07 |
|
NRT1/PTR family (NPF), subfamily 8 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF8 contains the Arabidopsis dipeptide transporters AtNPF8.1 (PTR1), AtNPF8.2 (PTR5), and AtNPF8.3 (PTR2), as well as tonoplast-localized transporters AtNPF8.4 (PTR4) and AtNPF8.5 (PTR6). Oryza sativa NRT1 (now called OsNPF8.9) is a low-affinity nitrate transporter. NPF8 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340976 [Multi-domain] Cd Length: 447 Bit Score: 52.09 E-value: 4.15e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 21 ERFAFYS-AKWLIAVFvvakvaEGGLGLTAADAAKMSANLVAFTYLAPVIGAFISDRLIGARYLVP-------IGMTLMG 92
Cdd:cd17418 14 ERLAYYGiATNLITYL------TKELHQGNVSAANNVTNWSGTCYITPLIGAFIADAYWGRYWTIAsfsaiyfIGMVLLT 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 93 AGYLV---------GWQASSAGMVNLMIV-----LVSLGTGLFKCQTSAITGRLFD--DPRQL---DSAFSIQYSFVNIG 153
Cdd:cd17418 88 LSASVpglkpasciGSLCPPATSVQYAVFflglyLIALGTGGIKPCVSSFGADQFDdtDPKEKvrkSSFFNWFYFSINIG 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 154 SFIGTTIIGVLVGTKGYAFCFLVCGIMMFIDAAWFIFGWKFLgetgkkpfkidehkeekqvketeEEKKPLTTMEKKRVG 233
Cdd:cd17418 168 ALISSSVLVWIQENVGWGWGFGIPTVFMGIAIVSFFFGTPLY-----------------------REVKILIRLLPIWAS 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 234 AIILVSFFSVIFWLFWYlaympvyfywggDNAAANWMIGNFQVPTA---WFDSLNALACIslgPILGKVWEKLAKRPQGD 310
Cdd:cd17418 225 GIVFATVYSQMSTMFVQ------------QGRTMDRMGGNFEIPPAslsLFDTLSVLIWV---PIYDRFIVPLVRKFTGH 289
|
330 340
....*....|....*....|....
gi 501309448 311 LSMFkkTALGMMLLGLSYVIFAMA 334
Cdd:cd17418 290 ERGF--TQLQRMGIGLFISVLSMV 311
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
11-190 |
5.38e-07 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 51.42 E-value: 5.38e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 11 FYVCSLAFtlerFAFYSAkWLIAVFVVAKVAEGGLGLTAADAAKMSANLVAFTYLAPVIGAFISDRlIGARYLVPIGMTL 90
Cdd:COG2223 207 FWLLSLLY----FGTFGS-FIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDR-IGGRRVLLIVFAL 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 91 MGAGY-LVGWQASSAGMVNLMIVLVSLGTGLFKCQTSAITGRLFdDPRQLDSAFSIQYSFVNIGSFIGTTIIGVLVG-TK 168
Cdd:COG2223 281 MALGLlLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIF-PTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDaTG 359
|
170 180
....*....|....*....|..
gi 501309448 169 GYAFCFLVCGIMMFIDAAWFIF 190
Cdd:COG2223 360 SYTAAFLVFAVLALVALVLTLL 381
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
65-386 |
8.08e-07 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 51.04 E-value: 8.08e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 65 LAPVIGAFISDRlIGARYLVPIGMTLMGAGYLVGWQASSAGMVNLMIVLVSLGTGLFKCQTSAITGRLFDdPRQLDSAFS 144
Cdd:cd17325 46 LFSPPAGRLSDR-FGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPAAMALIADIAP-PEERGRAMG 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 145 IQYSFVNIGSFIGTTIIGVLVGTKGYAFCFLVCGIMMFIDAAWFIfgwkflgetgkkpFKIDEHKEEKQVKETEEEKKPL 224
Cdd:cd17325 124 IFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLAL-------------LLLPEPRPPPNKRAVSAARLRS 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 225 TTMEKKRVGAIILVSFFSVIFWLFWYLAYMPVYFYWGGDNAAANWMIGnfqvptaWFDSLNALACISLGPILGKVWEKLA 304
Cdd:cd17325 191 GLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIG-------LLFGAQGLASALSQPPAGKLSDRIG 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 305 KRPQGdlsmfkktALGMMLLGLSYVIFAMADvtrggnlaSIAWIIAFGIVLSLGEMVFSPLGNSFISKFSPPRLLSVMMS 384
Cdd:cd17325 264 RKPLI--------LIGLLLSAVALLLLPLAT--------SFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMG 327
|
..
gi 501309448 385 VW 386
Cdd:cd17325 328 LF 329
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
9-190 |
3.63e-06 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 48.70 E-value: 3.63e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 9 FGFYVCSLAFTLERFAFYSAKWLIAVFVVAkvaeggLGLTAADAAKMSANLVAFTYLAPVIGAFISDR-LIGARYLVPIG 87
Cdd:cd17352 183 PTFVLLALGVSFAMLGFFVPFVYLPSYAKS------LGIDESDAAFLLSIIGISDIVGRILLGLLADKpRIGRLYLYIFT 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 88 MTLMGAGYLVGWQASSAGMVNLMIVLVSLGTGLFKCQTSAITGRLFDdPRQLDSAFSIQYSFVNIGSFIGTTIIGVLVG- 166
Cdd:cd17352 257 LLILGLSLLAFPLATTYVGLIVFSVLFGFCSGSYSSLTPVILADLVG-LEKLSNAYGLVLLFQGLAALVGPPIAGLLRDy 335
|
170 180
....*....|....*....|....
gi 501309448 167 TKGYAFCFLVCGIMMFIDAAWFIF 190
Cdd:cd17352 336 TGDYDAAFYFCGACLLLSGVLLFL 359
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
23-371 |
4.66e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 48.74 E-value: 4.66e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 23 FAFYSAKWLIAVFVVAKVAEGGLGLTAADAAKMSANLVAFTYLAPVIGAFISDRL---IGAR--YLVpIGMTLMGAGYLV 97
Cdd:COG2211 19 DLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTrtrWGRRrpWIL-IGAIPLALSFVL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 98 GWQASSAGMVNLMI------VLVSLGTGLFKCQTSAITGRLFDDPRQLDSAFSIQYSFVNIGSFIGTTIIGVLVGT---- 167
Cdd:COG2211 98 LFTAPDLSPTGKLIyalvtyLLLGLAYTLVNIPYSALGAELTPDYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAfggd 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 168 --KGYAFCFLVCGIMMFIDAAWFIFGWKflgetgkkpfkidEHKEEKQVKETeeEKKPLTTMEKKRVGAIILVSFFSVIF 245
Cdd:COG2211 178 aaLGYRLTALIFAVLGLLAFLLTFFGTK-------------ERPVPEEEKVS--LKESLKALLKNRPFLLLLLAYLLFFL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 246 WLFWYLAYMPVYF--YWGGDNAAANWMIGNFQVPtawfdslnALACISLGPILGKVWEKlakrpqgdlsmfKKT-ALGMM 322
Cdd:COG2211 243 ALALVAALLLYYFkyVLGLSAALVGLLLALYFLA--------ALLGAPLWPRLAKRFGK------------KKAfIIGLL 302
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 501309448 323 LLGLSYVIFAMADVTrggnlaSIAWIIAFGIVLSLGEMVFSPLGNSFIS 371
Cdd:COG2211 303 LAALGLLLLFFLGPG------NLWLLLVLAALAGIGLGAILVLPWAMLA 345
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
35-189 |
1.02e-05 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 47.54 E-value: 1.02e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 35 FVVAKVAEGGLGLTAADAAKMSANLVAFtyLAPVIGAFISDRlIGARYLVPIGMTLMGAGYLVGWQASSAGMVNLMIVLV 114
Cdd:cd17370 221 FLILRAQELGLSAALIPLLYALFNLVYA--LAAYPAGRLSDR-IGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILW 297
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 501309448 115 SLGTGLFKCQTSAITGRLFDDPRQlDSAFSIQYSFVNIGSFIGTTIIGVLVGTKGYAFCFLVCGIMMFIDAAWFI 189
Cdd:cd17370 298 GLYMGAQESIERAAVADLVPAELR-GTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLLLL 371
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
66-393 |
1.56e-05 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 46.80 E-value: 1.56e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 66 APVIGAFIsDRlIGARYLVPIGMTLMGAGYLVGWQASSAGMVNLMIVLVSLGTGLFKCQTSAITGRLFDDPRQlDSAFSI 145
Cdd:cd17473 52 APLAGWLA-DR-FGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEER-AKMLGL 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 146 QYSFVNIGSFIGTTIIGVLvGTKGYAFCFLV--CGIMMFIDAAWFIFgwkflgetgkkpfkideHKEEKQVKETEEEKKP 223
Cdd:cd17473 129 QSAAMSLGGVVFLLLGGAL-AEIGWRAPFLVylLALPVLILVLLFLP-----------------EPARKSKSAASPGAAT 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 224 LTTMEKKRVGAIILVSFFSVIFwLFWYLAYMPvyFYWGGDNAAANWMIGNfqvptawfdslnALACISLGPILGKVWEKL 303
Cdd:cd17473 191 AAALPWKRVLPIYFLAFLAMLL-FYVIPIQLP--FLLQERGGGSAALIGL------------ALAIASLAGAIGALLFGR 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 304 AKRPQGDLSMFkktALGMMLLGLSYVIFAMAdvtrggnlASIAWIIAFGIVLSLGEMVFSPLGNSFISKFSPPRLLSVMM 383
Cdd:cd17473 256 LKRRLGKRRLL---AIGFALMALGFLLLALA--------SGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAM 324
|
330
....*....|
gi 501309448 384 SVWILAVFFA 393
Cdd:cd17473 325 GIVTSAFFLG 334
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
126-365 |
2.51e-05 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 46.44 E-value: 2.51e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 126 SAITGRLFDDPRQLDSAFSIQYSFVNIGSFIGTTIIGVLV-------GTKGYAFCFLVCGIMMFIDAAWFIFGWKflget 198
Cdd:cd17332 121 TALIPELTDDPEERTSLTSWRMFFATIGGLLVTVLPPPLVayfgggnASRGYFLTALIIGIIGIILLLICFFGTR----- 195
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 199 gkkpfkiDEHKEEKQVKETEEEKKPLTTMEKKRvgAIILVSFFSVIFWLFW--YLAYMPVYF-YWGGDNAAANWMIGNFQ 275
Cdd:cd17332 196 -------ERVVPPEEEKSKLPLLKSLKALLKNR--PFLILLLAYLLYFLAFniVNTVLVYYFkYVLGGRAELVLLLLLIL 266
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 276 VptawfdslnalACISLGPILGKVWEKLAKRpqgdlsMFKKTALGMMLLGLSYVIFAMADvtrggnlaSIAWIIAFGIVL 355
Cdd:cd17332 267 S-----------GALLALLPWPPLKKRFGKK------KAFFIGLLLAILGLLLLFFLPPG--------NLVLILVLAVLA 321
|
250
....*....|
gi 501309448 356 SLGEMVFSPL 365
Cdd:cd17332 322 GIGYGGANLL 331
|
|
| 2A1704 |
TIGR00926 |
Peptide:H+ symporter (also transports b-lactam antibiotics, the antitumor agent, bestatin, and ... |
59-337 |
3.03e-05 |
|
Peptide:H+ symporter (also transports b-lactam antibiotics, the antitumor agent, bestatin, and various protease inhibitors); [Transport and binding proteins, Amino acids, peptides and amines]
Pssm-ID: 273343 [Multi-domain] Cd Length: 654 Bit Score: 46.29 E-value: 3.03e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 59 LVAFTYLAPVIGAFISDRLIGARYLVPIGMTLmgagYLVGWQASSAGMVN------------LMIVLVSLGTGLFKCQTS 126
Cdd:TIGR00926 32 FTYLCYLTPLIGAIIADGWLGKFKTILYLSIV----YVVGHALLSFGAIPssghplhdlldlLGLALIALGTGGIKPCVS 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 127 AITGRLF--DDPRQLDSAFSIQYSFVNIGSFIGTTIIGVLVGTKG-------YAFCFLVCGIMMFIDAAWFIFGWKFL-- 195
Cdd:TIGR00926 108 AFGGDQFeeRQLSLRSRFFSFFYFAINAGSLISTIITPILRGDVGcfgcqdcYPLAFGVPAILMILALIVFMAGSKMYkk 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 196 -----GETGKKPFKIDEHKEEKQvkETEEEKKPLTTMEKKRVGA---------IILVSFFSVI-FWLFWYLaYMPVYFYW 260
Cdd:TIGR00926 188 kppkgNIVSKVIKCIVTALRKRF--STRSEHWPLHWLDYAKDKHdirmirstkRLLRVLVLFIpLPMFWAL-FDQQGSRW 264
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 501309448 261 GGDNAAANWMIGNFQVPTAWFDSLNALACISLGPILGKVWEKLAKRPQGDLSMFKKTALGMMLLGLSYVIFAMADVT 337
Cdd:TIGR00926 265 TLQATRMDGDVGGFEIQPDQMQVVNPLLILIFVPIFDYIVYPAIAKCGTRFTSLRKMAVGGLLAALSFFVAALVQLK 341
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
45-183 |
3.33e-05 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 45.88 E-value: 3.33e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 45 LGLTAADAAKMSANLVAFTYLAPVIGAFISDRLIGARYLVPIGMTLMGAGYLVGWQASSAGMVNLMIVLVSLGTGLFKCQ 124
Cdd:cd06174 234 GGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPL 313
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 125 TSAITGRLFdDPRQLDSAFSIQYSFVNIGSFIGTTIIGVL-VGTKGYAFCFLVCGIMMFI 183
Cdd:cd06174 314 SFALIAELF-PPEIRGTAFGLLNTFGFLGGAIGPLLAGFLlAATFGLTGAFLVLAVLLLL 372
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
16-194 |
4.49e-05 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 45.63 E-value: 4.49e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 16 LAFTLERFAFYSA-KWLIAVFVvakvaegGLGLTAADAAKMSANLVAFTYLAPVIGAFISDRLIGARYLVPIGMTLMGAG 94
Cdd:COG2807 222 LFFGLQSLLYYAVvAWLPPILR-------DAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAG 294
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 95 YLVGWQASSAGMVnLMIVLVSLGTGLFKCQTSAITGRLFDDPRQLDSAFSIQYSFVNIGSFIGTTIIGVLVG-TKGYAFC 173
Cdd:COG2807 295 LLGLLLAPGSLPW-LWAVLLGLGQGGLFPLALTLIGLRARTPAEAAALSGMAQSVGYLLAALGPLLVGALHDaTGSWTAA 373
|
170 180
....*....|....*....|.
gi 501309448 174 FLVCGIMMfidAAWFIFGWKF 194
Cdd:COG2807 374 LLLLAALA---VLMLVAGLLA 391
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
40-279 |
4.86e-05 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 45.24 E-value: 4.86e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 40 VAEGGLGLTAADAAKMSANLVAFTyLAPVIGaFISDRlIGARYLVPIGMTLMGAG-YLVGWqASSAGMVNLMIVLVSLGT 118
Cdd:cd17478 23 IAKLGLSYAQAGLLVSVFSITSSL-LQPLFG-YLADR-KPRRYLLPLGPLLTGLGlSLLGF-APNYWLLLLLVALAGIGS 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 119 GLFKCQTSAITGRLFddPRQLDSAFSIQYSFVNIGSFIGTTIIGVLVGTKGYAFCFLVCGImMFIDAAWFIFGWKFLget 198
Cdd:cd17478 99 AAFHPEGARLASQAA--GGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLII-PGLAVALLLLRLRPL--- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 199 gkkpfkidehKEEKQVKETEEEKKPLTTMEKKRVGAIILVSFFSVIFWLFWYLAYMPVYF-YWGGDNAAANWMIGNFQVP 277
Cdd:cd17478 173 ----------KKPEAKKAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLvQRGYSLVFAGLLLSLFLFA 242
|
..
gi 501309448 278 TA 279
Cdd:cd17478 243 GA 244
|
|
| MFS_NPF5 |
cd17417 |
NRT1/PTR family (NPF), subfamily 5 of the Major Facilitator Superfamily of transporters; The ... |
20-338 |
7.47e-05 |
|
NRT1/PTR family (NPF), subfamily 5 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF5 includes Arabidopsis thaliana PTR3 (AtPTR3, now named AtNPF5.2), which is a wound-induced peptide transporter that is necessary for defense against virulent bacterial pathogens. NPF5 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340975 [Multi-domain] Cd Length: 452 Bit Score: 44.95 E-value: 7.47e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 20 LERFAFYS-AKWLIAVFVvakvaeGGLGLTAADAAKMSANLVAFTYLAPVIGAFISDRLIGaRY---LVPIGMTLMGAGY 95
Cdd:cd17417 13 AERFAYYGiASNLVTYLT------TPLHQSTARAAKNVNNWSGTATLLPLLGAFVADAYLG-RYrtiLISSLIYLLGLVL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 96 LV--------------GWQASSAGMVNLM----IVLVSLGTGLFKCQTSAITGRLFDDprQLDSAFSIQYSFVN------ 151
Cdd:cd17417 86 LTlsaslpslkppecnGTCSKASTLQVAFfffsLYLVAIGQGGHKPCVQAFGADQFDE--DDPKEKKQKSSFFNwwyfsi 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 152 -IGSFIGTTIIGVLVGTKGYAFCFLVCGIMMFIDAAWFIFGwkflgeTGKKPFKIDehkeekqvketeeekkplttmEKK 230
Cdd:cd17417 164 cAGSLTAVTVLVYIQDNVGWALGFGIPTIVMALALFVFLLG------TPLYRYKVE---------------------EVK 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 231 RVGAIILVSFFSVIFWLFWylAYMPVYFYWGGDNAAANwMIGNFQVPTAWFDSLNALACISLGPILGKVWEKLAKRPQGD 310
Cdd:cd17417 217 LVLRLIPIWFTTLVFTVVF--AQSPTFFTKQGVTMDRT-IGPNFKIPPASLQSFITLSILISIPIYDRVFVPIARKITGN 293
|
330 340 350
....*....|....*....|....*....|.
gi 501309448 311 ---LSMFKKTALGMMLLGLSYVIFAMADVTR 338
Cdd:cd17417 294 prgITLLQRIGIGMFLSILAMVIAALVEMKR 324
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
16-190 |
4.15e-04 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 42.17 E-value: 4.15e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 16 LAFTLERFAFYSAKWLIAVFVVAKVAEGGlGLTAADAAKMSANLVAFTYLAPVIGAFISDRLIG--ARYLVPIGMTLMGA 93
Cdd:cd17319 182 WGLALGYFGINYALYGLLTWLPTYLKQAR-GFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRgaRRLVIIIGLLLAAV 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 94 GYLVGWQASSAGMVNLMIVLVSLGTGLFKCQTSAITGRLFDdPRQLDSAFSIQYSFVNIGSFIGTTIIGVLVG-TKGYAF 172
Cdd:cd17319 261 GLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLP-GEAAATAGGLINSGGNLGGFVAPLLIGYLVDaTGSYTA 339
|
170
....*....|....*...
gi 501309448 173 CFLVCGIMMFIDAAWFIF 190
Cdd:cd17319 340 AFLFLAAVALLAALLVLL 357
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
45-189 |
4.60e-04 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 42.16 E-value: 4.60e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 45 LGLTAADAAKM-SANLVAFTYLAPVIGaFISDRlIGARYLVPIGMTLMGAGYLVGWQASSAGMVNLMIVLVSLGTGLFKC 123
Cdd:COG2271 40 LGLSAAQLGLLaSAFFLGYALGQIPAG-LLADR-FGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFP 117
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 501309448 124 QTSAITGRLFdDPRQLDSAFSIQYSFVNIGSFIGTTIIGVLVGTKGYAFCFLVCGIMMFIDAAWFI 189
Cdd:COG2271 118 AALKLIAEWF-PPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLALLRF 182
|
|
| MFS_NPF6 |
cd17413 |
NRT1/PTR family (NPF), subfamily 6 of the Major Facilitator Superfamily of transporters; The ... |
42-338 |
5.01e-04 |
|
NRT1/PTR family (NPF), subfamily 6 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter 1/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF6 includes the first identified member of the NRT1/PTR family: Arabidopsis thaliana NRT1.1, now called AtNPF6.3. It is a dual affinity nitrate influx transporter and a nitrate sensor. It also transports auxin and has nitrate efflux activity. NPF6 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340971 [Multi-domain] Cd Length: 457 Bit Score: 42.44 E-value: 5.01e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 42 EGGLGLTAADAAKMSANLVAFTYLAPVIGAFISDRLIGARYLVPIGMTLMGAGYLV------------------------ 97
Cdd:cd17413 30 TGTMHLPSATSANIVTNFLGTSFLLCLLGGFIADTFLGRYLTIAIFASIQALGVLVltlsttlpslrpppcnhttshhce 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 98 ---GWQASsagMVNLMIVLVSLGTGLFKCQTSAITGRLFD--DPR---QLDSAFSIQYSFVNIGSFIGTTIIGVLVGTKG 169
Cdd:cd17413 110 pasGIQLT---VLYLALYLIALGTGGIKSSVSGFGSDQFDenDPKerkLMSYFFNRFFFCISVGSLLAVTVLVYIQDNVG 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 170 YAFCFLVCGIMMFIDAAwfifgwKFLGETGKKPFKidehkeeKQVKETEEEkkplttmEKKRVGAIILVSFFSVIFWLFW 249
Cdd:cd17413 187 RGWGYGICAAAMVLAIV------VFLAGTKRYRFK-------KSIGSTQVE-------EVKMVVRMLPIWATTILFWTVY 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 250 ylAYMPVYFYWGGDNAAANwmIGNFQVPTA---WFDSLNALACISL-GPILGKVWEKLAKRPQGdLSMFKKTALGMMLLG 325
Cdd:cd17413 247 --AQMTTFSVEQAETMDRN--IGSFEIPPAsmaVFLVATILLTTAVyDRVIVPLCRKLTGHPQG-LTTLQRIGVGLVFSC 321
|
330
....*....|...
gi 501309448 326 LSYVIFAMADVTR 338
Cdd:cd17413 322 LAMAVAALVELKR 334
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
34-181 |
1.01e-03 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 41.10 E-value: 1.01e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 34 VFVVAKVAEGGLGLTAADAAkMSANLVAFTYLAPVIGAFIsDRlIGARYLVPIGMTLMGAGY-LVGWQASSAGMVNLMIV 112
Cdd:cd17355 24 VFIIPIIAEFGWSRAVISLA-FTVGLLAFGLAQPFVGRLL-DR-FGPRRVMLLGLLLLAAGLvLLALATSLWQLYLLWGL 100
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 113 LVSLGTG-LFKCQTSAITGRLFDDPRQLdsAFSIQYSFVNIGSFIGTTIIGVLVGTKGYAFCFLVCGIMM 181
Cdd:cd17355 101 LGGGGAGtLAAVAFATVAAWWFERRRGL--ALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLA 168
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
41-193 |
1.40e-03 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 40.61 E-value: 1.40e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 41 AEGGLGLTAADAAkmsaNLVAFTYLAPVIGAFISDRL---IGARYLVPIGMTLMGAGYLVGWQASSAGMVNLMIVLVSLG 117
Cdd:COG0738 237 LKDVLGLSEATAA----LGLSLFWGGMTIGRFLGGFLlkrFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLG 312
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 501309448 118 TGLFKCQTSAITGRLFddPRQLDSAFSIQYSFVNIGSFIGTTIIGVLVGTKGYAFCFLVCGIMMFIDAAWFIFGWK 193
Cdd:COG0738 313 LSLMFPTIFSLALDGL--GKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKR 386
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
4-183 |
1.52e-03 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 40.56 E-value: 1.52e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 4 TNKRPFGFYVCSLAFTLERFAFYsakwliAVFVVAKVAEGGLGLTAADAA-KMSANLVAFTYLAPVIGAfISDRlIGARY 82
Cdd:COG0477 9 TRRRRRALLALALGTFLEGLDFT------IVNVALPSIAADLGASSAQLGwIVSAYLLGRAIGLLLFGR-LGDR-YGRKR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 83 LVPIGMTLMGAGYLVGWQASSAGMVNLMIVLVSLGTGLFKCQTSAITGRLFDdPRQLDSAFSIQYSFVNIGSFIGTTIIG 162
Cdd:COG0477 81 VLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFP-ARERGRALGLWGAAIGLGLALGPLLGG 159
|
170 180
....*....|....*....|.
gi 501309448 163 VLVGTKGYAFCFLVCGIMMFI 183
Cdd:COG0477 160 LLVAALGWRWIFLINAPLGLL 180
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
45-247 |
1.52e-03 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 40.67 E-value: 1.52e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 45 LGLTAADAAKM-SANLVAFTYLAPVIGAFIsDRlIGARYLVPIGMTLMGAGYLVGWQASSAGMVNL-MIVLVSLGTGLFK 122
Cdd:cd17353 33 LGWSLASVALAfTLTIVFLAISAPFAGRLV-DR-GGPRKAILIGGILFGLGFILSAFAISLPLLFLgYGVLGGIGAGIGY 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 123 CQTSAITGRLFDDPRQLDSAFSIqySFVNIGSFIGTTIIGVLVGTKGYAFCFLVCGIMMFIdaawFIFGWKFLGETGKKP 202
Cdd:cd17353 111 ITPVSTAVKWFPDKRGLATGIVI--AGFGLGSLIFSPLIAYLINTVGVPTTFLILGIIFLI----IIVIGAFLIRDPPKG 184
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 501309448 203 FKIDEHKEEKQVKETEEEKKPLTTMEKKRVGAIILVSFFSVIFWL 247
Cdd:cd17353 185 WVPPGVDPLANNAENSPRDYTPREMLRTPTFWLLWLMFFLNATAG 229
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
55-190 |
1.74e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 40.27 E-value: 1.74e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 55 MSANLVAFTYLAPVIGAFIsDRLIGARYLVPiGMTLMGAGYLVGWQASSAGMVNLMIVLVSLGTG-LFKCQTSAITGRLf 133
Cdd:cd17489 233 FTVYAIALLLSRPFSGKLS-DRKGPKTVIIP-GLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGlLFPALQALAVDLV- 309
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 501309448 134 dDPRQLDSAFSIQYSFVNIGSFIGTTIIGVLVGTKGYAFCFLVCGIMMFIDAAWFIF 190
Cdd:cd17489 310 -PPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIF 365
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
65-332 |
2.13e-03 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 40.30 E-value: 2.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 65 LAPVIGAFiSDRL---IGAR--------YLVPIGMTLMG----AGYLVGWQASSAGMVNLMIVLVSLGTGLFKCQTSAIT 129
Cdd:cd17313 50 VQPLVGSL-SDRCnsrIGRRrpfilvgaPLAALGLILIPnaadIGLALGDGPRTWALVLFVLGIVLLDFAMNVCQGPVRA 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 130 gRLFD--DPRQLDSAFSIQYSFVNIGSFIGTTIIGVLVGTKG--------YAFCFLVCGIMMFIDAAWFIFgwkFLGETG 199
Cdd:cd17313 129 -LLPDlvPPEQRSKANGIINFMGGLGGVLGYLLGAILWDHNWfgfalggnLKVPFYIGAIILLVCVLVTLF---FVKEPP 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 200 KKPFKIDEHKEEKQVKETEEEKKPLTTMEK--KRVGAIILVSFFSVIFWLFWYLAYMPVYFYWGGDNAAANWMIGNFQvp 277
Cdd:cd17313 205 LSPEAGEHSENPSLGEVLKSLLKLLKIMPRslLRLLLVIFFWWIAFFPFELFFTDYMGEEVYHGTSAASSHYGAGVRM-- 282
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 501309448 278 TAWFDSLNALACISLGPILGKVWEKLAKRPQGDLSMFkKTALGMMLLGLSYVIFA 332
Cdd:cd17313 283 GAWGLLIFSLAFLIFSLPIGKLGKKIGRKKVYLIGLV-LFAVGMALMALVHNVTV 336
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
61-190 |
2.39e-03 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 39.86 E-value: 2.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 61 AFTYLAPVIGAFISDRLIGARYLVPIGMTLMGAGYLVGWQASSAGMVNLMIVLVSLGTGL-FKCQTSAITGRLFDDPRql 139
Cdd:cd17474 245 VLLALGSLFVGRLLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLnLPLLTTLVTELAPEEER-- 322
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 501309448 140 dSAFSIQYSFV-NIGSFIGTTIIGVLVGTKGYAFCFLVCGIMMFIdAAWFIF 190
Cdd:cd17474 323 -GTASSLYNFVrFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALA-AAVLLA 372
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
59-189 |
3.30e-03 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 39.45 E-value: 3.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 59 LVAFTYLAPVIGAFISDRLI--GARYLVPIGMTLMGAGYLVGWQASSAGMVNLMIVLVsLGTGLFKCQTSAITgRLFD-D 135
Cdd:cd17324 239 LLLLFGVAGVVGSPLAGRLAdrGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVL-WGLGFFAAHSALQT-RVLRlA 316
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 501309448 136 PRQLDSAFSIQYSFVNIGSFIGTTIIGVLVGTKGYAFCFLVCGIMMFIDAAWFI 189
Cdd:cd17324 317 PEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
31-183 |
3.45e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 39.48 E-value: 3.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 31 LIAVFVVAKVAEGGLGLTAADAAKMSANLVAFTyLAPVIGAFIsdRLIGARYLVPIGMTLMGAGYL-VGWQASSAGMVNL 109
Cdd:cd17504 200 LPQLLQLPTPTGFGLGITEAGLLLLPGALVMLI-AGPLAGRLI--ARVGPRRVLLIGLVISAVGLLlLALLHSSLWALVV 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501309448 110 MIVLVSLGTGLfkCQTSAITGRLFD-DPRQLDSAFSIQYSFVNIGSFIGTTIIGVLV-------------GTKGYAFCFL 175
Cdd:cd17504 277 ALLLIGIGLGL--AFASLPNIVVESvPPDRTGIATGMNTVLRTIGSAIGPAIAGAILttytvsitsggvpTEGAYVLAFL 354
|
....*...
gi 501309448 176 VCGIMMFI 183
Cdd:cd17504 355 IGAALALA 362
|
|
| |
