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Conserved domains on  [gi|501336290|ref|WP_012367925|]
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MULTISPECIES: TetR/AcrR family transcriptional regulator [Proteus]

Protein Classification

TetR/AcrR family transcriptional regulator( domain architecture ID 11442015)

TetR/AcrR family transcriptional regulator may control genes involved in one of a variety of processes including antibiotic production, osmotic stress response, efflux pump expression, and multidrug resistance

CATH:  1.10.10.60|1.10.357.10
Gene Ontology:  GO:0003700|GO:0003677|GO:0006355
PubMed:  23602932
SCOP:  4000333

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
13-124 7.83e-20

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


:

Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 81.87  E-value: 7.83e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501336290  13 TKPAEVRLEELMNAAETLFLEKGFDATTVSDIVKQAGVAKGTYYHYFTAKTDILDALRTRYMDWYIDKVEQAMAScqiQD 92
Cdd:COG1309    1 RRRREATRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALEEALAA---ED 77

                         90       100       110
                 ....*....|....*....|....*....|..
gi 501336290  93 FRAKLKQWCETSVIAYVEKQELHDMLFHQVFH 124
Cdd:COG1309   78 PRERLRALLRAYLEFLAENPALARLLLAEAAE 109
 
Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
13-124 7.83e-20

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 81.87  E-value: 7.83e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501336290  13 TKPAEVRLEELMNAAETLFLEKGFDATTVSDIVKQAGVAKGTYYHYFTAKTDILDALRTRYMDWYIDKVEQAMAScqiQD 92
Cdd:COG1309    1 RRRREATRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALEEALAA---ED 77

                         90       100       110
                 ....*....|....*....|....*....|..
gi 501336290  93 FRAKLKQWCETSVIAYVEKQELHDMLFHQVFH 124
Cdd:COG1309   78 PRERLRALLRAYLEFLAENPALARLLLAEAAE 109
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
23-69 3.69e-15

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 66.28  E-value: 3.69e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 501336290   23 LMNAAETLFLEKGFDATTVSDIVKQAGVAKGTYYHYFTAKTDILDAL 69
Cdd:pfam00440   1 ILDAARELFAERGYDATTVREIAKRAGVSKGALYRYFGSKEELLEAL 47
ScbR_bind_reg NF041196
ScbR family autoregulator-binding transcription factor;
23-68 5.76e-07

ScbR family autoregulator-binding transcription factor;


Pssm-ID: 469100 [Multi-domain]  Cd Length: 191  Bit Score: 47.59  E-value: 5.76e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 501336290  23 LMNAAETLFLEKGFDATTVSDIVKQAGVAKGTYYHYFTAKTDILDA 68
Cdd:NF041196  11 ILEAAAEVFDERGYAAATISDILERAGVTKGALYFHFSSKEALARA 56
PRK14996 PRK14996
TetR family transcriptional regulator; Provisional
 17-60 5.16e-05

TetR family transcriptional regulator; Provisional


Pssm-ID: 184958 [Multi-domain]  Cd Length: 192  Bit Score: 42.39  E-value: 5.16e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 501336290  17 EVRLEELMNAAETLFLEKGFDATTVSDIVKQAGVAKGTYYHYFT 60
Cdd:PRK14996   7 DERREVILQAAMRVALAEGFAAMTVRRIASEAQVAAGQVHHHFS 50
 
Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
13-124 7.83e-20

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 81.87  E-value: 7.83e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501336290  13 TKPAEVRLEELMNAAETLFLEKGFDATTVSDIVKQAGVAKGTYYHYFTAKTDILDALRTRYMDWYIDKVEQAMAScqiQD 92
Cdd:COG1309    1 RRRREATRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALEEALAA---ED 77

                         90       100       110
                 ....*....|....*....|....*....|..
gi 501336290  93 FRAKLKQWCETSVIAYVEKQELHDMLFHQVFH 124
Cdd:COG1309   78 PRERLRALLRAYLEFLAENPALARLLLAEAAE 109
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
23-69 3.69e-15

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 66.28  E-value: 3.69e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 501336290   23 LMNAAETLFLEKGFDATTVSDIVKQAGVAKGTYYHYFTAKTDILDAL 69
Cdd:pfam00440   1 ILDAARELFAERGYDATTVREIAKRAGVSKGALYRYFGSKEELLEAL 47
YbjK COG3226
DNA-binding transcriptional regulator YbjK [Transcription];
11-86 3.21e-07

DNA-binding transcriptional regulator YbjK [Transcription];


Pssm-ID: 442459 [Multi-domain]  Cd Length: 191  Bit Score: 48.40  E-value: 3.21e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 501336290  11 PRTKPAEVRLEELMNAAETLFLEKGFDATTVSDIVKQAGVAKGTYYHYFTAKTDILDALRTRYMDWYIDKVEQAMA 86
Cdd:COG3226    1 PRRRRGEERRERILEAALRVIARDGVRGVTHRAVAAEAGVPLGSTTYYFRTRDELLAAAFERLAEREAARLRALLA 76
ScbR_bind_reg NF041196
ScbR family autoregulator-binding transcription factor;
23-68 5.76e-07

ScbR family autoregulator-binding transcription factor;


Pssm-ID: 469100 [Multi-domain]  Cd Length: 191  Bit Score: 47.59  E-value: 5.76e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 501336290  23 LMNAAETLFLEKGFDATTVSDIVKQAGVAKGTYYHYFTAKTDILDA 68
Cdd:NF041196  11 ILEAAAEVFDERGYAAATISDILERAGVTKGALYFHFSSKEALARA 56
PRK14996 PRK14996
TetR family transcriptional regulator; Provisional
 17-60 5.16e-05

TetR family transcriptional regulator; Provisional


Pssm-ID: 184958 [Multi-domain]  Cd Length: 192  Bit Score: 42.39  E-value: 5.16e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 501336290  17 EVRLEELMNAAETLFLEKGFDATTVSDIVKQAGVAKGTYYHYFT 60
Cdd:PRK14996   7 DERREVILQAAMRVALAEGFAAMTVRRIASEAQVAAGQVHHHFS 50
PRK10668 PRK10668
DNA-binding transcriptional repressor AcrR; Provisional
 17-67 7.38e-05

DNA-binding transcriptional repressor AcrR; Provisional


Pssm-ID: 182632 [Multi-domain]  Cd Length: 215  Bit Score: 41.92  E-value: 7.38e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 501336290  17 EVRlEELMNAAETLFLEKGFDATTVSDIVKQAGVAKGTYYHYFTAKTDILD 67
Cdd:PRK10668  11 ETR-QHILDAALRLFSQQGVSATSLADIAKAAGVTRGAIYWHFKNKSDLFS 60
PRK00767 PRK00767
transcriptional regulator BetI; Validated
 11-68 1.34e-04

transcriptional regulator BetI; Validated


Pssm-ID: 179115 [Multi-domain]  Cd Length: 197  Bit Score: 40.98  E-value: 1.34e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 501336290  11 PRTKPAEVRLEELMNAAETLFLEKGFDATTVSDIVKQAGVAKGTYYHYFTAKTDILDA 68
Cdd:PRK00767   2 PKVGMEPIRRQQLIDATLRAIGEVGLLDATIAQIARRAGVSTGIISHYFGGKDGLLEA 59
PRK09975 PRK09975
DNA-binding transcriptional regulator EnvR; Provisional
 12-69 5.44e-04

DNA-binding transcriptional regulator EnvR; Provisional


Pssm-ID: 182177 [Multi-domain]  Cd Length: 213  Bit Score: 39.34  E-value: 5.44e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 501336290  12 RTKPAEVRL-EELMNAAETLFLEKGFDATTVSDIVKQAGVAKGTYYHYFTAKTDILDAL 69
Cdd:PRK09975   4 KTKAEALKTrQELIETAIAQFALRGVSNTTLNDIADAANVTRGAIYWHFENKTQLFNEM 62
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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