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Conserved domains on  [gi|501385665|ref|WP_012417231|]
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peroxidase-related enzyme [Bordetella avium]

Protein Classification

carboxymuconolactone decarboxylase family protein( domain architecture ID 571)

carboxymuconolactone decarboxylase family protein, similar to Enterobacter hormaechei YciW

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ahpD_dom super family cl00460
alkylhydroperoxidase AhpD family core domain; This model represents a 51-residue core region ...
 19-194 7.73e-75

alkylhydroperoxidase AhpD family core domain; This model represents a 51-residue core region of homology among a family of mostly uncharacterized proteins of 110 to 227 amino acids. Most members of this family contain the motif EXXXXXX[SA]XXXXXC[VIL]XCXXXH. Members of the family include the alkylhydroperoxidase AhpD of Mycobacterium tuberculosis, a macrophage infectivity potentiator peptide of Legionella pneumophila, and an uncharacterized peptide in the tetrachloroethene reductive dehalogenase operon of Dehalospirillum multivorans. We suggest that many peptides containing this domain may have alkylhydroperoxidase or related antioxidant activity. [Unknown function, General]


The actual alignment was detected with superfamily member TIGR01926:

Pssm-ID: 469777 [Multi-domain]  Cd Length: 177  Bit Score: 222.67  E-value: 7.73e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501385665   19 AWLDTVRVESATPEQIAVLEESHPKAK-TSDYYLFLIHQPEILRQRSTAFNAIMYAPGGLSRAERELGATVVSRINGCVY 97
Cdd:TIGR01926   1 SRLDVVDLAELTEEQKAYLAKIEEKTGfVPNVFRALAHDPEALRARTAYFNDLMLGEGGLSRAERELIAVVVSRANGCVY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501385665   98 CASVHAQRFEQLAKRNDVIAEVFDDPRTAGTTERERAIAAFSVKITENPAGLDAKDIRALKEVGLSEGEILDLVHADAIF 177
Cdd:TIGR01926  81 CAAVHGAALRQLSGDPDLADAVAVNFRDADLSPRERAMLDFAVKLTATPAKVNEADFAALRAAGFSDLDILDLIHSVAFF 160

                         170
                  ....*....|....*..
gi 501385665  178 AWANRLMLNLGEPIFPQ 194
Cdd:TIGR01926 161 NWANRLMLALGEPPNPE 177
 
Name Accession Description Interval E-value
peroxid_rel TIGR01926
uncharacterized peroxidase-related enzyme; This protein family with length of about 200 amino ...
 19-194 7.73e-75

uncharacterized peroxidase-related enzyme; This protein family with length of about 200 amino acids. One member, from Myxococcus xanthus, is a selenoprotein, with an otherwise conserved Cys replaced by Sec. This family is drawn narrowly enough to suggest that These proteins contain a domain described by TIGR00778, with a CxxCxxxHxxxxxxxG motif. Some members of that family are known to act as peroxidases or correlate with resistance to oxidative stress.


Pssm-ID: 130981 [Multi-domain]  Cd Length: 177  Bit Score: 222.67  E-value: 7.73e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501385665   19 AWLDTVRVESATPEQIAVLEESHPKAK-TSDYYLFLIHQPEILRQRSTAFNAIMYAPGGLSRAERELGATVVSRINGCVY 97
Cdd:TIGR01926   1 SRLDVVDLAELTEEQKAYLAKIEEKTGfVPNVFRALAHDPEALRARTAYFNDLMLGEGGLSRAERELIAVVVSRANGCVY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501385665   98 CASVHAQRFEQLAKRNDVIAEVFDDPRTAGTTERERAIAAFSVKITENPAGLDAKDIRALKEVGLSEGEILDLVHADAIF 177
Cdd:TIGR01926  81 CAAVHGAALRQLSGDPDLADAVAVNFRDADLSPRERAMLDFAVKLTATPAKVNEADFAALRAAGFSDLDILDLIHSVAFF 160

                         170
                  ....*....|....*..
gi 501385665  178 AWANRLMLNLGEPIFPQ 194
Cdd:TIGR01926 161 NWANRLMLALGEPPNPE 177
YciW COG2128
Alkylhydroperoxidase family enzyme, contains CxxC motif [Inorganic ion transport and ...
 57-194 8.53e-40

Alkylhydroperoxidase family enzyme, contains CxxC motif [Inorganic ion transport and metabolism];


Pssm-ID: 441731 [Multi-domain]  Cd Length: 142  Bit Score: 132.31  E-value: 8.53e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501385665  57 PEILRQRSTAFNAIMyAPGGLSRAERELGATVVSRINGCVYCASVHAQRFEQLAKRNDVIAEVFDDPRTAGTTERERAIA 136
Cdd:COG2128    3 PELLKAFLALSGALM-AKGGLSPRERELVALRVSQINGCAYCLDAHTAIARKAGLDEERIDALRAWRESPLFDPRERAAL 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 501385665 137 AFSVKITENPAGLDAKDIRALKEvGLSEGEILDLVHADAIFAWANRLMLNLGEPIFPQ 194
Cdd:COG2128   82 AFAEALTRTPGGVSDADVAALRA-GFSDAEIVELVLAIALFNMSNRLNNALGTPPDPP 138
CMD pfam02627
Carboxymuconolactone decarboxylase family; Carboxymuconolactone decarboxylase (CMD) EC:4.1.1. ...
 57-138 1.31e-10

Carboxymuconolactone decarboxylase family; Carboxymuconolactone decarboxylase (CMD) EC:4.1.1.44 is involved in protocatechuate catabolism. In some bacteria a gene fusion event leads to expression of CMD with a hydrolase involved in the same pathway. In these bifunctional proteins CMD represents the C-terminal domain, pfam00561 represents the N-terminal domain.


Pssm-ID: 460628 [Multi-domain]  Cd Length: 84  Bit Score: 55.40  E-value: 1.31e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501385665   57 PEILRQRsTAFNAIMYAPGGLSRAERELGATVVSRINGCVYCASVHAQRFEQLAKRNDVIAEVFDDPRTAGTTERERAIA 136
Cdd:pfam02627   1 PELLAAL-TALAFGLLWDGGLDPKTRELIALAVSAANGCAYCLDAHTRAALKAGVTEEEIAEVLAWAAAYAGGPAARAAL 79


                  ..
gi 501385665  137 AF 138
Cdd:pfam02627  80 AA 81
 
Name Accession Description Interval E-value
peroxid_rel TIGR01926
uncharacterized peroxidase-related enzyme; This protein family with length of about 200 amino ...
 19-194 7.73e-75

uncharacterized peroxidase-related enzyme; This protein family with length of about 200 amino acids. One member, from Myxococcus xanthus, is a selenoprotein, with an otherwise conserved Cys replaced by Sec. This family is drawn narrowly enough to suggest that These proteins contain a domain described by TIGR00778, with a CxxCxxxHxxxxxxxG motif. Some members of that family are known to act as peroxidases or correlate with resistance to oxidative stress.


Pssm-ID: 130981 [Multi-domain]  Cd Length: 177  Bit Score: 222.67  E-value: 7.73e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501385665   19 AWLDTVRVESATPEQIAVLEESHPKAK-TSDYYLFLIHQPEILRQRSTAFNAIMYAPGGLSRAERELGATVVSRINGCVY 97
Cdd:TIGR01926   1 SRLDVVDLAELTEEQKAYLAKIEEKTGfVPNVFRALAHDPEALRARTAYFNDLMLGEGGLSRAERELIAVVVSRANGCVY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501385665   98 CASVHAQRFEQLAKRNDVIAEVFDDPRTAGTTERERAIAAFSVKITENPAGLDAKDIRALKEVGLSEGEILDLVHADAIF 177
Cdd:TIGR01926  81 CAAVHGAALRQLSGDPDLADAVAVNFRDADLSPRERAMLDFAVKLTATPAKVNEADFAALRAAGFSDLDILDLIHSVAFF 160

                         170
                  ....*....|....*..
gi 501385665  178 AWANRLMLNLGEPIFPQ 194
Cdd:TIGR01926 161 NWANRLMLALGEPPNPE 177
perox_Avi_7169 TIGR04030
alkylhydroperoxidase domain protein, Avi_7169 family; Members of this family represent a ...
 10-190 3.33e-55

alkylhydroperoxidase domain protein, Avi_7169 family; Members of this family represent a narrow clade that falls within a family of alkylhydroperoxidase-related proteins, fused to or adjacent to a sequence described by TIGR04029. These two partners occur almost always in the context of a putative FMN-dependent luciferase-like monooxygenase (LLM) (TIGR04027), and an ABC transporter in which TIGR04028 models the substrate-binding protein.


Pssm-ID: 188545  Cd Length: 185  Bit Score: 173.43  E-value: 3.33e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501385665   10 FTNESLEWKAWLDTVRVESATPEQIAVLEEshPKAKTSDYYLFLIHQPEILRQRSTAFNAIMYAPG-GLSRAERELGATV 88
Cdd:TIGR04030   5 FTQDELGWEPWIAPKPLAEFTEEEQAALIR--PGRADSPYFRLLARDPPALEARTLTDLDIFYNPGgGLPRAERELAATV 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501385665   89 VSRINGCVYCASVHAQRFEQLAKRNDVIAEVFDD-PRTAGTTERERAIAAFSVKITENPAGLDAKDIRALKEVGLSEGEI 167
Cdd:TIGR04030  83 TSRYNGCIYCASVHARKASQLSKRRDDVQRLLDVgPGADLGSERWQAIIDAAAALSATPAAFNAAHVAALRAQGLDDLAI 162

                         170       180
                  ....*....|....*....|...
gi 501385665  168 LDLVHADAIFAWANRLMLNLGEP 190
Cdd:TIGR04030 163 VDLIQSAAFFNWANRLMLTLGEP 185
YciW COG2128
Alkylhydroperoxidase family enzyme, contains CxxC motif [Inorganic ion transport and ...
 57-194 8.53e-40

Alkylhydroperoxidase family enzyme, contains CxxC motif [Inorganic ion transport and metabolism];


Pssm-ID: 441731 [Multi-domain]  Cd Length: 142  Bit Score: 132.31  E-value: 8.53e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501385665  57 PEILRQRSTAFNAIMyAPGGLSRAERELGATVVSRINGCVYCASVHAQRFEQLAKRNDVIAEVFDDPRTAGTTERERAIA 136
Cdd:COG2128    3 PELLKAFLALSGALM-AKGGLSPRERELVALRVSQINGCAYCLDAHTAIARKAGLDEERIDALRAWRESPLFDPRERAAL 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 501385665 137 AFSVKITENPAGLDAKDIRALKEvGLSEGEILDLVHADAIFAWANRLMLNLGEPIFPQ 194
Cdd:COG2128   82 AFAEALTRTPGGVSDADVAALRA-GFSDAEIVELVLAIALFNMSNRLNNALGTPPDPP 138
CMD pfam02627
Carboxymuconolactone decarboxylase family; Carboxymuconolactone decarboxylase (CMD) EC:4.1.1. ...
 57-138 1.31e-10

Carboxymuconolactone decarboxylase family; Carboxymuconolactone decarboxylase (CMD) EC:4.1.1.44 is involved in protocatechuate catabolism. In some bacteria a gene fusion event leads to expression of CMD with a hydrolase involved in the same pathway. In these bifunctional proteins CMD represents the C-terminal domain, pfam00561 represents the N-terminal domain.


Pssm-ID: 460628 [Multi-domain]  Cd Length: 84  Bit Score: 55.40  E-value: 1.31e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501385665   57 PEILRQRsTAFNAIMYAPGGLSRAERELGATVVSRINGCVYCASVHAQRFEQLAKRNDVIAEVFDDPRTAGTTERERAIA 136
Cdd:pfam02627   1 PELLAAL-TALAFGLLWDGGLDPKTRELIALAVSAANGCAYCLDAHTRAALKAGVTEEEIAEVLAWAAAYAGGPAARAAL 79


                  ..
gi 501385665  137 AF 138
Cdd:pfam02627  80 AA 81
ahpD_dom TIGR00778
alkylhydroperoxidase AhpD family core domain; This model represents a 51-residue core region ...
 75-120 3.59e-07

alkylhydroperoxidase AhpD family core domain; This model represents a 51-residue core region of homology among a family of mostly uncharacterized proteins of 110 to 227 amino acids. Most members of this family contain the motif EXXXXXX[SA]XXXXXC[VIL]XCXXXH. Members of the family include the alkylhydroperoxidase AhpD of Mycobacterium tuberculosis, a macrophage infectivity potentiator peptide of Legionella pneumophila, and an uncharacterized peptide in the tetrachloroethene reductive dehalogenase operon of Dehalospirillum multivorans. We suggest that many peptides containing this domain may have alkylhydroperoxidase or related antioxidant activity. [Unknown function, General]


Pssm-ID: 273266 [Multi-domain]  Cd Length: 50  Bit Score: 45.44  E-value: 3.59e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 501385665   75 GGLSRAERELGATVVSRINGCVYCASVHAQRFEQLAKRNDVIAEVF 120
Cdd:TIGR00778   1 GALDAATKELIAIAVSQINGCGYCLDAHTKLARKAGVTREELAEAL 46
YurZ COG0599
Uncharacterized conserved protein YurZ, alkylhydroperoxidase/carboxymuconolactone ...
 57-120 8.07e-03

Uncharacterized conserved protein YurZ, alkylhydroperoxidase/carboxymuconolactone decarboxylase family [General function prediction only];


Pssm-ID: 440364  Cd Length: 114  Bit Score: 34.93  E-value: 8.07e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 501385665  57 PEILRQRSTAFNAImYAPGGLSRAERELGATVVSRINGCVYCASVHAQRfeqlAKRNDV----IAEVF 120
Cdd:COG0599   23 PEFAEAFEALFGDV-WARGALDPKTRELITLAALAALGCEPCLKAHVRA----ALNAGAtreeIAEAL 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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