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Conserved domains on  [gi|501447070|ref|WP_012470519|]
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type I-E CRISPR-associated endoribonuclease Cas2e [Trichlorobacter lovleyi]

Protein Classification

type I-E CRISPR-associated endoribonuclease Cas2( domain architecture ID 10013831)

type I-E CRISPR-associated endoribonuclease Cas2 complexes with Cas1; the complex is involved in CRISPR adaptation, the first stage of CRISPR immunity, being required for the addition/removal of CRISPR spacers at the leader end of the CRISPR locus

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK11558 PRK11558
putative ssRNA endonuclease; Provisional
 1-95 1.45e-62

putative ssRNA endonuclease; Provisional


:

Pssm-ID: 236930  Cd Length: 97  Bit Score: 184.46  E-value: 1.45e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501447070  1 MLVIVTENVPPRLRGRLGLWLVEVRAGVYVGDVSRRVREMIWDNLEKGVEDGNAVMAWTSNNESGFDFLTLGTNRRIPVE 80
Cdd:PRK11558  3 MLVVVTENVPPRLRGRLAVWLLEVRAGVYVGDVSRRIREMIWQQVTQLAEEGNVVMAWATNTESGFEFQTFGENRRIPVD 82

                        90
                ....*....|....*
gi 501447070 81 MDGIKLVSFLPEGNQ 95
Cdd:PRK11558 83 LDGLRLVSFLPVENQ 97
 
Name Accession Description Interval E-value
PRK11558 PRK11558
putative ssRNA endonuclease; Provisional
 1-95 1.45e-62

putative ssRNA endonuclease; Provisional


Pssm-ID: 236930  Cd Length: 97  Bit Score: 184.46  E-value: 1.45e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501447070  1 MLVIVTENVPPRLRGRLGLWLVEVRAGVYVGDVSRRVREMIWDNLEKGVEDGNAVMAWTSNNESGFDFLTLGTNRRIPVE 80
Cdd:PRK11558  3 MLVVVTENVPPRLRGRLAVWLLEVRAGVYVGDVSRRIREMIWQQVTQLAEEGNVVMAWATNTESGFEFQTFGENRRIPVD 82

                        90
                ....*....|....*
gi 501447070 81 MDGIKLVSFLPEGNQ 95
Cdd:PRK11558 83 LDGLRLVSFLPVENQ 97
Cas_Cas2CT1978 pfam09707
CRISPR-associated protein (Cas_Cas2CT1978); This entry represents a minor branch of the Cas2 ...
 1-86 2.15e-49

CRISPR-associated protein (Cas_Cas2CT1978); This entry represents a minor branch of the Cas2 family of CRISPR-associated protein which are found in IPR003799. Cas proteins are found adjacent to a characteriztic short, palindromic repeat cluster termed CRISPR, a probable mobile DNA element.


Pssm-ID: 430765  Cd Length: 86  Bit Score: 150.75  E-value: 2.15e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501447070   1 MLVIVTENVPPRLRGRLGLWLVEVRAGVYVGDVSRRVREMIWDNLEKGVEDGNAVMAWTSNNESGFDFLTLGTNRRIPVE 80
Cdd:pfam09707  1 MTVIVLEAVPPRLRGRLTRWLLEVRPGVYVGRVSARVRERLWERVSEWIGDGSAVMVWSTNNEQGFAFRTLGDNRREPVD 80


                 ....*.
gi 501447070  81 MDGIKL 86
Cdd:pfam09707 81 FDGLTL 86
Cas2_I-E cd09648
CRISPR/Cas system-associated protein Cas2; CRISPR (Clustered Regularly Interspaced Short ...
 1-91 1.86e-38

CRISPR/Cas system-associated protein Cas2; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold


Pssm-ID: 187779  Cd Length: 93  Bit Score: 123.77  E-value: 1.86e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501447070  1 MLVIVTENVPPRLRGRLGLWLVEVRAGVYVGDVSRRVREMIWDNLEK-GVEDGNAVMAWTSNNESGFDFLTLGTNRRIPV 79
Cdd:cd09648   1 MLVVVTENVPPRLRGRLALWLLEPRAGVYVGGVSASVRERIWDYLAQhCPPKGSLVITWSSNTCPGFEFFTLGENRKEIV 80

                        90
                ....*....|...
gi 501447070 80 EMDGIKLV-SFLP 91
Cdd:cd09648  81 EIDGLPLViRALP 93
cas_CT1978 TIGR01873
CRISPR-associated endoribonuclease Cas2, subtype I-E/ECOLI; CRISPR is a term for Clustered, ...
 1-86 3.10e-37

CRISPR-associated endoribonuclease Cas2, subtype I-E/ECOLI; CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This model represents a minor branch of the Cas2 family of CRISPR-associated endonuclease, whereas most Cas2 proteins are modeled instead by TIGR01573. This form of Cas2 is characteristic for the Ecoli subtype of CRISPR/Cas locus.


Pssm-ID: 233610  Cd Length: 87  Bit Score: 120.30  E-value: 3.10e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501447070   1 MLVIVTENVPPRLRGRLGLWLVEVRAGVYVGDVSRRVREMIWDNLEK-GVEDGNAVMAWTSNNESGFDFLTLGTNRRIPV 79
Cdd:TIGR01873  1 MLVVVTENVPPRLRGRLALWLLEVRAGVYVGDVSAKVRERIWEQLAQlCAEKGSVVMTWATNTETGFEFQTLGENRKEIV 80


                 ....*..
gi 501447070  80 EMDGIKL 86
Cdd:TIGR01873 81 EIDGLRL 87
 
Name Accession Description Interval E-value
PRK11558 PRK11558
putative ssRNA endonuclease; Provisional
 1-95 1.45e-62

putative ssRNA endonuclease; Provisional


Pssm-ID: 236930  Cd Length: 97  Bit Score: 184.46  E-value: 1.45e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501447070  1 MLVIVTENVPPRLRGRLGLWLVEVRAGVYVGDVSRRVREMIWDNLEKGVEDGNAVMAWTSNNESGFDFLTLGTNRRIPVE 80
Cdd:PRK11558  3 MLVVVTENVPPRLRGRLAVWLLEVRAGVYVGDVSRRIREMIWQQVTQLAEEGNVVMAWATNTESGFEFQTFGENRRIPVD 82

                        90
                ....*....|....*
gi 501447070 81 MDGIKLVSFLPEGNQ 95
Cdd:PRK11558 83 LDGLRLVSFLPVENQ 97
Cas_Cas2CT1978 pfam09707
CRISPR-associated protein (Cas_Cas2CT1978); This entry represents a minor branch of the Cas2 ...
 1-86 2.15e-49

CRISPR-associated protein (Cas_Cas2CT1978); This entry represents a minor branch of the Cas2 family of CRISPR-associated protein which are found in IPR003799. Cas proteins are found adjacent to a characteriztic short, palindromic repeat cluster termed CRISPR, a probable mobile DNA element.


Pssm-ID: 430765  Cd Length: 86  Bit Score: 150.75  E-value: 2.15e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501447070   1 MLVIVTENVPPRLRGRLGLWLVEVRAGVYVGDVSRRVREMIWDNLEKGVEDGNAVMAWTSNNESGFDFLTLGTNRRIPVE 80
Cdd:pfam09707  1 MTVIVLEAVPPRLRGRLTRWLLEVRPGVYVGRVSARVRERLWERVSEWIGDGSAVMVWSTNNEQGFAFRTLGDNRREPVD 80


                 ....*.
gi 501447070  81 MDGIKL 86
Cdd:pfam09707 81 FDGLTL 86
Cas2_I-E cd09648
CRISPR/Cas system-associated protein Cas2; CRISPR (Clustered Regularly Interspaced Short ...
 1-91 1.86e-38

CRISPR/Cas system-associated protein Cas2; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold


Pssm-ID: 187779  Cd Length: 93  Bit Score: 123.77  E-value: 1.86e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501447070  1 MLVIVTENVPPRLRGRLGLWLVEVRAGVYVGDVSRRVREMIWDNLEK-GVEDGNAVMAWTSNNESGFDFLTLGTNRRIPV 79
Cdd:cd09648   1 MLVVVTENVPPRLRGRLALWLLEPRAGVYVGGVSASVRERIWDYLAQhCPPKGSLVITWSSNTCPGFEFFTLGENRKEIV 80

                        90
                ....*....|...
gi 501447070 80 EMDGIKLV-SFLP 91
Cdd:cd09648  81 EIDGLPLViRALP 93
cas_CT1978 TIGR01873
CRISPR-associated endoribonuclease Cas2, subtype I-E/ECOLI; CRISPR is a term for Clustered, ...
 1-86 3.10e-37

CRISPR-associated endoribonuclease Cas2, subtype I-E/ECOLI; CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This model represents a minor branch of the Cas2 family of CRISPR-associated endonuclease, whereas most Cas2 proteins are modeled instead by TIGR01573. This form of Cas2 is characteristic for the Ecoli subtype of CRISPR/Cas locus.


Pssm-ID: 233610  Cd Length: 87  Bit Score: 120.30  E-value: 3.10e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501447070   1 MLVIVTENVPPRLRGRLGLWLVEVRAGVYVGDVSRRVREMIWDNLEK-GVEDGNAVMAWTSNNESGFDFLTLGTNRRIPV 79
Cdd:TIGR01873  1 MLVVVTENVPPRLRGRLALWLLEVRAGVYVGDVSAKVRERIWEQLAQlCAEKGSVVMTWATNTETGFEFQTLGENRKEIV 80


                 ....*..
gi 501447070  80 EMDGIKL 86
Cdd:TIGR01873 81 EIDGLRL 87
Cas2_I-E cd09755
CRISPR/Cas system-associated protein Cas2; CRISPR (Clustered Regularly Interspaced Short ...
 25-86 1.73e-31

CRISPR/Cas system-associated protein Cas2; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold


Pssm-ID: 187885  Cd Length: 62  Bit Score: 104.97  E-value: 1.73e-31
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 501447070 25 RAGVYVGDVSRRVREMIWDNLEKGVEDGNAVMAWTSNNESGFDFLTLGTNRRIPVEMDGIKL 86
Cdd:cd09755   1 RAGVYVGNVSARVRERLWEKVTEGIGDGSAVMVWSTNNEQGFSFRTLGDPRREPVDFDGLLL 62
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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