NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|501453104|ref|WP_012476553|]
View 

four-helix bundle copper-binding protein [Leptospira biflexa]

Protein Classification

four-helix bundle copper-binding protein( domain architecture ID 10025149)

four-helix bundle copper-binding protein similar to Methylosinus trichosporium copper storage protein 1 (Csp1) that is exported from the cytosol, and stores copper for particulate methane monooxygenase

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
TAT_Cys_rich TIGR04401
twin-arginine translocation signal/Cys-rich four helix bundle protein; Members of this family ...
 1-147 5.74e-48

twin-arginine translocation signal/Cys-rich four helix bundle protein; Members of this family average about 150 amino acids in length, beginning with a twin-arginine translocation signal sequence, then a His-rich spacer region, followed by a ~105-residue region in which thirteen positions are nearly invariant Cys residues. CDD (Conserved Domain Database) assigns members of this family to clan cl13994, the DUF326 superfamily, based on homology to PA2107 from Pseudomonas aeruginosa. PA2107 is a cysteine-rich four helical bundle protein, with solved structure PDB:3KAW.


:

Pssm-ID: 275194  Cd Length: 150  Bit Score: 151.85  E-value: 5.74e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501453104    1 MNRKELLQKAGMAVAVSGILSTLSAEDH----DHSTAMPTAGKsKYAKAMMAAIHCQLSAEVCLSHCITELGKGDKAMAA 76
Cdd:TIGR04401   1 MNRREFITAAGAAAALAAAASAAAAAGHhhahDHGHHHPAAAA-KYAALLEAAAHCVSTGEACLAHCLRLLSMGDTSMAA 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 501453104   77 CAASTREVISLCDSFVKLASQNSSFTKKLANLCVEVCEACAKECDKHANHHAVCKECRDSCLACAKELKKV 147
Cdd:TIGR04401  80 CAKAVNQMLALCAALQSLAAQNSPLTPALAKVCAEACEACAKECKKHADHHAECKACGDSCKACAEECKKV 150
 
Name Accession Description Interval E-value
TAT_Cys_rich TIGR04401
twin-arginine translocation signal/Cys-rich four helix bundle protein; Members of this family ...
 1-147 5.74e-48

twin-arginine translocation signal/Cys-rich four helix bundle protein; Members of this family average about 150 amino acids in length, beginning with a twin-arginine translocation signal sequence, then a His-rich spacer region, followed by a ~105-residue region in which thirteen positions are nearly invariant Cys residues. CDD (Conserved Domain Database) assigns members of this family to clan cl13994, the DUF326 superfamily, based on homology to PA2107 from Pseudomonas aeruginosa. PA2107 is a cysteine-rich four helical bundle protein, with solved structure PDB:3KAW.


Pssm-ID: 275194  Cd Length: 150  Bit Score: 151.85  E-value: 5.74e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501453104    1 MNRKELLQKAGMAVAVSGILSTLSAEDH----DHSTAMPTAGKsKYAKAMMAAIHCQLSAEVCLSHCITELGKGDKAMAA 76
Cdd:TIGR04401   1 MNRREFITAAGAAAALAAAASAAAAAGHhhahDHGHHHPAAAA-KYAALLEAAAHCVSTGEACLAHCLRLLSMGDTSMAA 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 501453104   77 CAASTREVISLCDSFVKLASQNSSFTKKLANLCVEVCEACAKECDKHANHHAVCKECRDSCLACAKELKKV 147
Cdd:TIGR04401  80 CAKAVNQMLALCAALQSLAAQNSPLTPALAKVCAEACEACAKECKKHADHHAECKACGDSCKACAEECKKV 150
DUF326 cd08026
Cysteine-rich 4 helical bundle widely conserved in bacteria; This functionally uncharacterized ...
 42-147 1.73e-17

Cysteine-rich 4 helical bundle widely conserved in bacteria; This functionally uncharacterized protein forms a 4-helical bundle with a bromodomain-like topology. It is present in major bacterial lineages and contains highly conserved cysteines in a repeated pattern, whose sidechains appear buried. Some family members have been (mis)annotated as putative ferredoxins.


Pssm-ID: 153434  Cd Length: 102  Bit Score: 72.34  E-value: 1.73e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501453104  42 YAKAMMAAIHCQLSAEVCLSHCITElgKGDKAMAACAASTREVISLCDSFVKLASQNSSFTKKLANLCVEVCEACAKECD 121
Cdd:cd08026    1 MQECIDACLACARACEECADACLEE--GGVHAMAECIRLDLDCADICRLAANLMSRGSPFAKALCALCAEICEACAEECE 78

                         90       100
                 ....*....|....*....|....*.
gi 501453104 122 KHAnhHAVCKECRDSCLACAKELKKV 147
Cdd:cd08026   79 KHA--HEHCQECAEACRRCAEACRKM 102
 
Name Accession Description Interval E-value
TAT_Cys_rich TIGR04401
twin-arginine translocation signal/Cys-rich four helix bundle protein; Members of this family ...
 1-147 5.74e-48

twin-arginine translocation signal/Cys-rich four helix bundle protein; Members of this family average about 150 amino acids in length, beginning with a twin-arginine translocation signal sequence, then a His-rich spacer region, followed by a ~105-residue region in which thirteen positions are nearly invariant Cys residues. CDD (Conserved Domain Database) assigns members of this family to clan cl13994, the DUF326 superfamily, based on homology to PA2107 from Pseudomonas aeruginosa. PA2107 is a cysteine-rich four helical bundle protein, with solved structure PDB:3KAW.


Pssm-ID: 275194  Cd Length: 150  Bit Score: 151.85  E-value: 5.74e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501453104    1 MNRKELLQKAGMAVAVSGILSTLSAEDH----DHSTAMPTAGKsKYAKAMMAAIHCQLSAEVCLSHCITELGKGDKAMAA 76
Cdd:TIGR04401   1 MNRREFITAAGAAAALAAAASAAAAAGHhhahDHGHHHPAAAA-KYAALLEAAAHCVSTGEACLAHCLRLLSMGDTSMAA 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 501453104   77 CAASTREVISLCDSFVKLASQNSSFTKKLANLCVEVCEACAKECDKHANHHAVCKECRDSCLACAKELKKV 147
Cdd:TIGR04401  80 CAKAVNQMLALCAALQSLAAQNSPLTPALAKVCAEACEACAKECKKHADHHAECKACGDSCKACAEECKKV 150
DUF326 cd08026
Cysteine-rich 4 helical bundle widely conserved in bacteria; This functionally uncharacterized ...
 42-147 1.73e-17

Cysteine-rich 4 helical bundle widely conserved in bacteria; This functionally uncharacterized protein forms a 4-helical bundle with a bromodomain-like topology. It is present in major bacterial lineages and contains highly conserved cysteines in a repeated pattern, whose sidechains appear buried. Some family members have been (mis)annotated as putative ferredoxins.


Pssm-ID: 153434  Cd Length: 102  Bit Score: 72.34  E-value: 1.73e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501453104  42 YAKAMMAAIHCQLSAEVCLSHCITElgKGDKAMAACAASTREVISLCDSFVKLASQNSSFTKKLANLCVEVCEACAKECD 121
Cdd:cd08026    1 MQECIDACLACARACEECADACLEE--GGVHAMAECIRLDLDCADICRLAANLMSRGSPFAKALCALCAEICEACAEECE 78

                         90       100
                 ....*....|....*....|....*.
gi 501453104 122 KHAnhHAVCKECRDSCLACAKELKKV 147
Cdd:cd08026   79 KHA--HEHCQECAEACRRCAEACRKM 102
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH