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Conserved domains on  [gi|501507147|ref|WP_012515084|]
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cell cycle regulator CcrZ [Streptococcus equi]

Protein Classification

phosphotransferase family protein( domain architecture ID 10001645)

phosphotransferase family protein similar to Streptococcus pneumoniae LicA, a choline kinase that catalyzes the transfer of the gamma-phosphoryl group from ATP (or CTP) to choline, producing phosphorylcholine, a precursor to the biosynthesis of two major membrane phospholipids, phosphatidylcholine and sphingomyelin

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CotS COG0510
Thiamine kinase or a related kinase [Coenzyme transport and metabolism];
92-257 5.97e-24

Thiamine kinase or a related kinase [Coenzyme transport and metabolism];


:

Pssm-ID: 440276 [Multi-domain]  Cd Length: 156  Bit Score: 94.08  E-value: 5.97e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501507147  92 RLHKSKQLVnqllqlnykienPYDLLVDFEQNAPLQIQQNSYLQAIVKELKRSLPEFRSEVAtIVHGDIKHSNWVITTSG 171
Cdd:COG0510    1 RLHASPALL------------RFDLFARLERYLALGPRDLPELLRRLEELERALAARPLPLV-LCHGDLHPGNFLVTDDG 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501507147 172 MIFLVDWDCVRLTDRMYDVAYLLSHY-IPRSRWADWLSYYGYKN-NDKVMQKIIWYAQFSYLTQILRCFDKRDmEHVNQE 249
Cdd:COG0510   68 RLYLIDWEYAGLGDPAFDLAALLVEYgLSPEQAEELLEAYGFGRpTEELLRRLRAYRALADLLWALWALVRAA-QEANGD 146

                        170
                 ....*....|
gi 501507147 250 I--YALRKFR 257
Cdd:COG0510  147 LlkYLLRRLE 156
 
Name Accession Description Interval E-value
CotS COG0510
Thiamine kinase or a related kinase [Coenzyme transport and metabolism];
92-257 5.97e-24

Thiamine kinase or a related kinase [Coenzyme transport and metabolism];


Pssm-ID: 440276 [Multi-domain]  Cd Length: 156  Bit Score: 94.08  E-value: 5.97e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501507147  92 RLHKSKQLVnqllqlnykienPYDLLVDFEQNAPLQIQQNSYLQAIVKELKRSLPEFRSEVAtIVHGDIKHSNWVITTSG 171
Cdd:COG0510    1 RLHASPALL------------RFDLFARLERYLALGPRDLPELLRRLEELERALAARPLPLV-LCHGDLHPGNFLVTDDG 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501507147 172 MIFLVDWDCVRLTDRMYDVAYLLSHY-IPRSRWADWLSYYGYKN-NDKVMQKIIWYAQFSYLTQILRCFDKRDmEHVNQE 249
Cdd:COG0510   68 RLYLIDWEYAGLGDPAFDLAALLVEYgLSPEQAEELLEAYGFGRpTEELLRRLRAYRALADLLWALWALVRAA-QEANGD 146

                        170
                 ....*....|
gi 501507147 250 I--YALRKFR 257
Cdd:COG0510  147 LlkYLLRRLE 156
APH pfam01636
Phosphotransferase enzyme family; This family consists of bacterial antibiotic resistance ...
 40-211 6.61e-12

Phosphotransferase enzyme family; This family consists of bacterial antibiotic resistance proteins, which confer resistance to various aminoglycosides they include: aminoglycoside 3'-phosphotransferase or kanamycin kinase / neomycin-kanamycin phosphotransferase and streptomycin 3''-kinase or streptomycin 3''-phosphotransferase. The aminoglycoside phosphotransferases inactivate aminoglycoside antibiotics via phosphorylation. This family also includes homoserine kinase. This family is related to fructosamine kinase pfam03881.


Pssm-ID: 426359 [Multi-domain]  Cd Length: 239  Bit Score: 63.67  E-value: 6.61e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501507147   40 ILPALAKEQI--APQLLW--AKRMGNGDMMSAQEWLNGRTLTREDMNSKQ------IVHILLRLHKSKQLV-------NQ 102
Cdd:pfam01636  43 LLRHLAAAGVppVPRVLAgcTDAELLGLPFLLMEYLPGEVLARPLLPEERgalleaLGRALARLHAVDPAAlplagrlAR 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501507147  103 LLQLNYKIENPYDLLVDFEqnapLQIQQNSYLQAIVKELKRSLPEFRSEVatIVHGDIKHSNWVITTSGMIF-LVDWDCV 181
Cdd:pfam01636 123 LLELLRQLEAALARLLAAE----LLDRLEELEERLLAALLALLPAELPPV--LVHGDLHPGNLLVDPGGRVSgVIDFEDA 196

                         170       180       190
                  ....*....|....*....|....*....|
gi 501507147  182 RLTDRMYDVAYLLSHYiPRSRWADWLSYYG 211
Cdd:pfam01636 197 GLGDPAYDLAILLNSW-GRELGAELLAAYL 225
ACAD10_11_N-like cd05154
N-terminal domain of Acyl-CoA dehydrogenase (ACAD) 10 and 11, and similar proteins; This ...
 141-211 1.82e-04

N-terminal domain of Acyl-CoA dehydrogenase (ACAD) 10 and 11, and similar proteins; This subfamily is composed of the N-terminal domains of vertebrate ACAD10 and ACAD11, and similar uncharacterized bacterial and eukaryotic proteins. ACADs are a family of flavoproteins that are involved in the beta-oxidation of fatty acyl-CoA derivatives. ACAD deficiency can cause metabolic disorders including muscle fatigue, hypoglycemia, and hepatic lipidosis. There are at least 11 distinct ACADs, some of which show distinct substrate specificities to either straight-chain or branched-chain fatty acids. ACAD10 is widely expressed in human tissues and highly expressed in liver, kidney, pancreas, and spleen. ACAD10 and ACAD11 are both significantly expressed in human brain tissues. They contain a long N-terminal domain with similarity to phosphotransferases with a Protein Kinase fold, which is absent in other ACADs. They may exhibit multiple functions in acyl-CoA oxidation pathways. ACAD11 utilizes substrates with carbon chain lengths of 20 to 26, with optimal activity towards C22CoA. ACAD10 may be associated with an increased risk in type II diabetes. The ACAD10/11-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 270703 [Multi-domain]  Cd Length: 254  Bit Score: 41.83  E-value: 1.82e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 501507147 141 LKRSLPEfrSEVATIVHGDIKHSNwvittsgMIF--------LVDWDCVRLTDRMYDVAYLLSHYIPRSRWADWLSYYG 211
Cdd:cd05154  167 LRANLPA--DGRPVLVHGDFRLGN-------LLFdpdgrvtaVLDWELATLGDPLEDLAWLLARWWRPGDPPGLAAPTR 236
 
Name Accession Description Interval E-value
CotS COG0510
Thiamine kinase or a related kinase [Coenzyme transport and metabolism];
92-257 5.97e-24

Thiamine kinase or a related kinase [Coenzyme transport and metabolism];


Pssm-ID: 440276 [Multi-domain]  Cd Length: 156  Bit Score: 94.08  E-value: 5.97e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501507147  92 RLHKSKQLVnqllqlnykienPYDLLVDFEQNAPLQIQQNSYLQAIVKELKRSLPEFRSEVAtIVHGDIKHSNWVITTSG 171
Cdd:COG0510    1 RLHASPALL------------RFDLFARLERYLALGPRDLPELLRRLEELERALAARPLPLV-LCHGDLHPGNFLVTDDG 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501507147 172 MIFLVDWDCVRLTDRMYDVAYLLSHY-IPRSRWADWLSYYGYKN-NDKVMQKIIWYAQFSYLTQILRCFDKRDmEHVNQE 249
Cdd:COG0510   68 RLYLIDWEYAGLGDPAFDLAALLVEYgLSPEQAEELLEAYGFGRpTEELLRRLRAYRALADLLWALWALVRAA-QEANGD 146

                        170
                 ....*....|
gi 501507147 250 I--YALRKFR 257
Cdd:COG0510  147 LlkYLLRRLE 156
APH pfam01636
Phosphotransferase enzyme family; This family consists of bacterial antibiotic resistance ...
 40-211 6.61e-12

Phosphotransferase enzyme family; This family consists of bacterial antibiotic resistance proteins, which confer resistance to various aminoglycosides they include: aminoglycoside 3'-phosphotransferase or kanamycin kinase / neomycin-kanamycin phosphotransferase and streptomycin 3''-kinase or streptomycin 3''-phosphotransferase. The aminoglycoside phosphotransferases inactivate aminoglycoside antibiotics via phosphorylation. This family also includes homoserine kinase. This family is related to fructosamine kinase pfam03881.


Pssm-ID: 426359 [Multi-domain]  Cd Length: 239  Bit Score: 63.67  E-value: 6.61e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501507147   40 ILPALAKEQI--APQLLW--AKRMGNGDMMSAQEWLNGRTLTREDMNSKQ------IVHILLRLHKSKQLV-------NQ 102
Cdd:pfam01636  43 LLRHLAAAGVppVPRVLAgcTDAELLGLPFLLMEYLPGEVLARPLLPEERgalleaLGRALARLHAVDPAAlplagrlAR 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501507147  103 LLQLNYKIENPYDLLVDFEqnapLQIQQNSYLQAIVKELKRSLPEFRSEVatIVHGDIKHSNWVITTSGMIF-LVDWDCV 181
Cdd:pfam01636 123 LLELLRQLEAALARLLAAE----LLDRLEELEERLLAALLALLPAELPPV--LVHGDLHPGNLLVDPGGRVSgVIDFEDA 196

                         170       180       190
                  ....*....|....*....|....*....|
gi 501507147  182 RLTDRMYDVAYLLSHYiPRSRWADWLSYYG 211
Cdd:pfam01636 197 GLGDPAYDLAILLNSW-GRELGAELLAAYL 225
CotI COG5881
Spore coat protein CotI/CotS, protein kinase superfamily [Cell cycle control, cell division, ...
 61-233 1.01e-05

Spore coat protein CotI/CotS, protein kinase superfamily [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444583 [Multi-domain]  Cd Length: 331  Bit Score: 46.04  E-value: 1.01e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501507147  61 NGDMMSAQEWLNGRTLT---REDMnsKQIVHILLRLHK-SKQLV-------------------NQLLQLN--------YK 109
Cdd:COG5881   81 GGKLYYLTEWIEGRECDyknPEDL--KKAAETLAEFHKaSKGFEpppgskgrshlgkwperfeKRLEELEkfkkiaekKK 158

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501507147 110 IENPYDLL----VDFEQN---APLQIQQNSYLQAIVKELKRSLpefrsevaTIVHGDIKHSNWVITTSGMIFLVDWDCVR 182
Cdd:COG5881  159 NKNEFDRLflknIDYFLEqaeKALELLEKSAYYKLVKEAKKEG--------GFCHHDYAYHNILIDEDGKIYIIDFDYCI 230

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 501507147 183 LTDRMYDVAYLLSHYIPRSRWadwlsyygykNNDKVMQKIIWYAQFSYLTQ 233
Cdd:COG5881  231 YDLPVHDLAKLLRRVMKRGNW----------DIEKAKEILEAYNKINPLSK 271
SrkA COG2334
Ser/Thr protein kinase RdoA involved in Cpx stress response, MazF antagonist [Signal ...
 69-210 6.07e-05

Ser/Thr protein kinase RdoA involved in Cpx stress response, MazF antagonist [Signal transduction mechanisms]; Ser/Thr protein kinase RdoA involved in Cpx stress response, MazF antagonist is part of the Pathway/BioSystem: Threonine biosynthesis


Pssm-ID: 441905 [Multi-domain]  Cd Length: 297  Bit Score: 43.38  E-value: 6.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501507147  69 EWLNGRTLtrEDMNSKQIVHI--LL-RLHkskqlvnQLLQlNYKIENPYDL------LVDFEQNAPLQIQQNSYLQAIVK 139
Cdd:COG2334   95 PFLPGRSP--EEPSPEQLEELgrLLaRLH-------RALA-DFPRPNARDLawwdelLERLLGPLLPDPEDRALLEELLD 164

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 501507147 140 ELKRSLPEFRSEVAT-IVHGDIKHSNWVITTSGMIFLVDWDCVRLTDRMYDVAYLLS----HYIPRSRWADWLSYY 210
Cdd:COG2334  165 RLEARLAPLLGALPRgVIHGDLHPDNVLFDGDGVSGLIDFDDAGYGPRLYDLAIALNgwadGPLDPARLAALLEGY 240
ACAD10_11_N-like cd05154
N-terminal domain of Acyl-CoA dehydrogenase (ACAD) 10 and 11, and similar proteins; This ...
 141-211 1.82e-04

N-terminal domain of Acyl-CoA dehydrogenase (ACAD) 10 and 11, and similar proteins; This subfamily is composed of the N-terminal domains of vertebrate ACAD10 and ACAD11, and similar uncharacterized bacterial and eukaryotic proteins. ACADs are a family of flavoproteins that are involved in the beta-oxidation of fatty acyl-CoA derivatives. ACAD deficiency can cause metabolic disorders including muscle fatigue, hypoglycemia, and hepatic lipidosis. There are at least 11 distinct ACADs, some of which show distinct substrate specificities to either straight-chain or branched-chain fatty acids. ACAD10 is widely expressed in human tissues and highly expressed in liver, kidney, pancreas, and spleen. ACAD10 and ACAD11 are both significantly expressed in human brain tissues. They contain a long N-terminal domain with similarity to phosphotransferases with a Protein Kinase fold, which is absent in other ACADs. They may exhibit multiple functions in acyl-CoA oxidation pathways. ACAD11 utilizes substrates with carbon chain lengths of 20 to 26, with optimal activity towards C22CoA. ACAD10 may be associated with an increased risk in type II diabetes. The ACAD10/11-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 270703 [Multi-domain]  Cd Length: 254  Bit Score: 41.83  E-value: 1.82e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 501507147 141 LKRSLPEfrSEVATIVHGDIKHSNwvittsgMIF--------LVDWDCVRLTDRMYDVAYLLSHYIPRSRWADWLSYYG 211
Cdd:cd05154  167 LRANLPA--DGRPVLVHGDFRLGN-------LLFdpdgrvtaVLDWELATLGDPLEDLAWLLARWWRPGDPPGLAAPTR 236
YcbJ COG3173
Predicted kinase, aminoglycoside phosphotransferase (APT) family [General function prediction ...
 40-205 2.87e-04

Predicted kinase, aminoglycoside phosphotransferase (APT) family [General function prediction only];


Pssm-ID: 442406 [Multi-domain]  Cd Length: 284  Bit Score: 41.25  E-value: 2.87e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501507147  40 ILPALAKEQI--APQLLWAKR--MGNGDMMSAQEWLNGRTLTREDMN---------SKQIVHILLRLH------------ 94
Cdd:COG3173   66 VLRALAPRLGvpVPRPLALGEdgEVIGAPFYVMEWVEGETLEDALPDlspaerralARALGEFLAALHavdpaaagladg 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501507147  95 KSKQLVNQLLQLnykiENPYDLLVDFEQNAPLqiqqnsYLQAIVKELKRSLPEFRSevATIVHGDIKHSN--WVITTSGM 172
Cdd:COG3173  146 RPEGLERQLARW----RAQLRRALARTDDLPA------LRERLAAWLAANLPEWGP--PVLVHGDLRPGNllVDPDDGRL 213

                        170       180       190
                 ....*....|....*....|....*....|...
gi 501507147 173 IFLVDWDCVRLTDRMYDVAYLLSHYIPRSRWAD 205
Cdd:COG3173  214 TAVIDWELATLGDPAADLAYLLLYWRLPDDLLG 246
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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